ARSG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)6.88867325
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.93167352
3L-phenylalanine catabolic process (GO:0006559)5.93167352
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.29950889
5L-phenylalanine metabolic process (GO:0006558)5.29950889
6ensheathment of neurons (GO:0007272)5.13735060
7axon ensheathment (GO:0008366)5.13735060
8myelination (GO:0042552)5.11688152
9myelin maintenance (GO:0043217)5.02560575
10response to methylmercury (GO:0051597)4.59880687
11long-chain fatty acid biosynthetic process (GO:0042759)4.50297551
12DNA deamination (GO:0045006)4.46191176
13very long-chain fatty acid metabolic process (GO:0000038)4.07711968
14long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.04511130
15cholesterol biosynthetic process (GO:0006695)4.00359579
16aromatic amino acid family catabolic process (GO:0009074)3.97346440
17creatine metabolic process (GO:0006600)3.83798893
18amyloid precursor protein metabolic process (GO:0042982)3.82748117
19fatty-acyl-CoA biosynthetic process (GO:0046949)3.80848861
20establishment of mitochondrion localization (GO:0051654)3.73781866
21fucose catabolic process (GO:0019317)3.72453575
22L-fucose metabolic process (GO:0042354)3.72453575
23L-fucose catabolic process (GO:0042355)3.72453575
24L-amino acid import (GO:0043092)3.71211013
25response to pheromone (GO:0019236)3.69530498
26heme transport (GO:0015886)3.68693902
27detection of light stimulus involved in sensory perception (GO:0050962)3.65480155
28detection of light stimulus involved in visual perception (GO:0050908)3.65480155
29platelet dense granule organization (GO:0060155)3.65213843
30long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.62808922
31regulation of lipoprotein metabolic process (GO:0050746)3.56969646
32sterol biosynthetic process (GO:0016126)3.56182552
33neural tube formation (GO:0001841)3.55142049
34negative regulation of neurotransmitter transport (GO:0051589)3.53776310
35fatty-acyl-CoA metabolic process (GO:0035337)3.52817015
36behavioral response to nicotine (GO:0035095)3.51357577
37import into cell (GO:0098657)3.48412043
38oligodendrocyte differentiation (GO:0048709)3.45532930
39negative regulation of mast cell activation (GO:0033004)3.40326832
40glycerophospholipid catabolic process (GO:0046475)3.36748676
41indole-containing compound catabolic process (GO:0042436)3.35850540
42indolalkylamine catabolic process (GO:0046218)3.35850540
43tryptophan catabolic process (GO:0006569)3.35850540
44alpha-linolenic acid metabolic process (GO:0036109)3.32644448
45negative regulation of neurotransmitter secretion (GO:0046929)3.32330665
46detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.31520819
47dopamine transport (GO:0015872)3.31016395
48negative regulation of protein localization to cell surface (GO:2000009)3.30601500
49iron coordination entity transport (GO:1901678)3.27272140
50photoreceptor cell differentiation (GO:0046530)3.26042571
51eye photoreceptor cell differentiation (GO:0001754)3.26042571
52thioester biosynthetic process (GO:0035384)3.22318655
53acyl-CoA biosynthetic process (GO:0071616)3.22318655
54bile acid biosynthetic process (GO:0006699)3.21203769
55indolalkylamine metabolic process (GO:0006586)3.18262133
56cytidine deamination (GO:0009972)3.16903446
57cytidine metabolic process (GO:0046087)3.16903446
58cytidine catabolic process (GO:0006216)3.16903446
59axoneme assembly (GO:0035082)3.12760869
60regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.12072297
61positive regulation of oligodendrocyte differentiation (GO:0048714)3.08358110
62amine catabolic process (GO:0009310)3.07727723
63cellular biogenic amine catabolic process (GO:0042402)3.07727723
64membrane tubulation (GO:0097320)3.05094253
65amyloid precursor protein catabolic process (GO:0042987)3.05001195
66glyoxylate metabolic process (GO:0046487)3.04100155
67ketone body metabolic process (GO:1902224)3.02812417
68dicarboxylic acid catabolic process (GO:0043649)3.02405081
69regulation of collateral sprouting (GO:0048670)3.00983483
70kynurenine metabolic process (GO:0070189)3.00291981
71coenzyme catabolic process (GO:0009109)2.97155634
72tyrosine metabolic process (GO:0006570)2.92235166
73tryptophan metabolic process (GO:0006568)2.91123430
74aspartate family amino acid catabolic process (GO:0009068)2.90360649
75respiratory chain complex IV assembly (GO:0008535)2.89696357
76response to lead ion (GO:0010288)2.89401323
77glycine transport (GO:0015816)2.88107707
78response to mercury ion (GO:0046689)2.87046546
79pyrimidine ribonucleoside catabolic process (GO:0046133)2.84888811
80protein localization to cilium (GO:0061512)2.83842719
81behavioral response to ethanol (GO:0048149)2.83725014
82peptidyl-tyrosine autophosphorylation (GO:0038083)2.82951127
83response to lipoprotein particle (GO:0055094)2.82145533
84isoprenoid biosynthetic process (GO:0008299)2.81201274
85water-soluble vitamin biosynthetic process (GO:0042364)2.81043314
86antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.80695201
87regulation of memory T cell differentiation (GO:0043380)2.79819029
88antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.79512149
89thioester metabolic process (GO:0035383)2.77368099
90acyl-CoA metabolic process (GO:0006637)2.77368099
91L-serine metabolic process (GO:0006563)2.76645791
92positive regulation of cellular amine metabolic process (GO:0033240)2.75666515
93aromatic amino acid family metabolic process (GO:0009072)2.75216448
94cofactor catabolic process (GO:0051187)2.75027680
95adult walking behavior (GO:0007628)2.74202301
96neuron remodeling (GO:0016322)2.73535660
97presynaptic membrane organization (GO:0097090)2.73262279
98phosphatidylinositol acyl-chain remodeling (GO:0036149)2.72306659
99response to redox state (GO:0051775)2.71050061
100inositol phosphate catabolic process (GO:0071545)2.70907137
101bile acid metabolic process (GO:0008206)2.70646114
102short-chain fatty acid metabolic process (GO:0046459)2.70212943
103apical protein localization (GO:0045176)2.70203832
104cytochrome complex assembly (GO:0017004)2.69981494
105negative regulation of cAMP-mediated signaling (GO:0043951)2.66648662
106cholesterol metabolic process (GO:0008203)2.65954902
107piRNA metabolic process (GO:0034587)2.65157332
108polyol catabolic process (GO:0046174)2.61821454
109negative regulation of interleukin-1 production (GO:0032692)2.61037832
110nonmotile primary cilium assembly (GO:0035058)2.59976692
111asymmetric protein localization (GO:0008105)2.59527779
112establishment of protein localization to Golgi (GO:0072600)2.59046680
113adaptation of signaling pathway (GO:0023058)2.58852372
114substantia nigra development (GO:0021762)2.56708648
115auditory receptor cell stereocilium organization (GO:0060088)2.56427822
116negative regulation of telomere maintenance (GO:0032205)2.55786795
117regulation of cholesterol biosynthetic process (GO:0045540)2.55747812
118astrocyte development (GO:0014002)2.55587358
119ethanol oxidation (GO:0006069)2.53726548
120photoreceptor cell maintenance (GO:0045494)2.51768300
121protein complex biogenesis (GO:0070271)2.51349674
122pyrimidine nucleobase catabolic process (GO:0006208)2.51179639
123axon development (GO:0061564)2.50600245
124amino acid import (GO:0043090)2.49369503
125protein K11-linked deubiquitination (GO:0035871)2.49321734
126mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.48843211
127mitochondrial respiratory chain complex I assembly (GO:0032981)2.48843211
128NADH dehydrogenase complex assembly (GO:0010257)2.48843211
129glutathione biosynthetic process (GO:0006750)2.48470289
130aldehyde catabolic process (GO:0046185)2.48149892
131negative regulation of interleukin-1 beta production (GO:0032691)2.47865762
132sterol metabolic process (GO:0016125)2.47826209
133epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.47790964
134cornea development in camera-type eye (GO:0061303)2.47558221
135multicellular organism reproduction (GO:0032504)2.46894306
136proline transport (GO:0015824)2.46889033
137magnesium ion transport (GO:0015693)2.46326380
138opsonization (GO:0008228)2.46006461
139neuronal action potential (GO:0019228)2.45988326
140positive regulation of defense response to virus by host (GO:0002230)2.45726463
141negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45658936
142acetyl-CoA metabolic process (GO:0006084)2.45658364
143glutamate metabolic process (GO:0006536)2.45595343
144signal peptide processing (GO:0006465)2.45518020
145transmission of nerve impulse (GO:0019226)2.44725900
146triglyceride biosynthetic process (GO:0019432)2.44138420
147neurotransmitter uptake (GO:0001504)2.43839785
148reciprocal meiotic recombination (GO:0007131)2.43080664
149reciprocal DNA recombination (GO:0035825)2.43080664
150regulation of cholesterol metabolic process (GO:0090181)2.42558693
151cellular ketone body metabolic process (GO:0046950)2.42421826
152preassembly of GPI anchor in ER membrane (GO:0016254)2.42081615
153triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.41036719
154activated T cell proliferation (GO:0050798)2.40582903
155kidney morphogenesis (GO:0060993)2.39942857
156fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.39396497
157nucleobase catabolic process (GO:0046113)2.39019165
158acylglycerol biosynthetic process (GO:0046463)2.38740978
159neutral lipid biosynthetic process (GO:0046460)2.38740978
160serine family amino acid biosynthetic process (GO:0009070)2.38692039
161cAMP catabolic process (GO:0006198)2.38516514
162glycosylceramide metabolic process (GO:0006677)2.37605392
163drug transmembrane transport (GO:0006855)2.36657916
164positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.36140381
165reflex (GO:0060004)2.36071304
166antigen processing and presentation of endogenous antigen (GO:0019883)2.35464816
167detection of temperature stimulus involved in sensory perception (GO:0050961)2.35371540
168detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.35371540
169glutathione derivative biosynthetic process (GO:1901687)2.35000544
170glutathione derivative metabolic process (GO:1901685)2.35000544
171positive regulation of lipoprotein lipase activity (GO:0051006)2.34727339
172cyclic nucleotide catabolic process (GO:0009214)2.34317962
173inositol phosphate dephosphorylation (GO:0046855)2.33823591
174phosphorylated carbohydrate dephosphorylation (GO:0046838)2.33823591
175endosome to pigment granule transport (GO:0043485)2.33309572
176endosome to melanosome transport (GO:0035646)2.33309572
177regulation of cilium movement (GO:0003352)2.32341212
178positive regulation of fatty acid transport (GO:2000193)2.31483981
179cilium morphogenesis (GO:0060271)2.27724785
180gamma-aminobutyric acid transport (GO:0015812)2.27710899
181epithelial cilium movement (GO:0003351)2.26746727
182positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.25905143
183catecholamine transport (GO:0051937)2.25785343
184double-strand break repair via homologous recombination (GO:0000724)2.25462910
185recombinational repair (GO:0000725)2.25141256
186tachykinin receptor signaling pathway (GO:0007217)2.24352686
187protein targeting to Golgi (GO:0000042)2.24264616
188visual perception (GO:0007601)2.24209815
189sensory perception of light stimulus (GO:0050953)2.22390507
190indole-containing compound metabolic process (GO:0042430)2.22213105
191NAD biosynthetic process (GO:0009435)2.21798233
192superoxide anion generation (GO:0042554)2.21542582
193embryonic epithelial tube formation (GO:0001838)2.21538613
194sulfation (GO:0051923)2.21249166
195inner ear receptor stereocilium organization (GO:0060122)2.19404439
196regulation of neurotransmitter uptake (GO:0051580)2.18981935
197photoreceptor cell development (GO:0042461)2.18607099
198axon ensheathment in central nervous system (GO:0032291)10.1576023
199central nervous system myelination (GO:0022010)10.1576023

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.65656608
2ZNF274_21170338_ChIP-Seq_K562_Hela3.43131737
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.74224434
4* RXR_22158963_ChIP-Seq_LIVER_Mouse2.70652993
5IGF1R_20145208_ChIP-Seq_DFB_Human2.51617681
6GBX2_23144817_ChIP-Seq_PC3_Human2.51607912
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.46146396
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.20882851
9SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.18578933
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.18063013
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.12409084
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.06144859
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.00223056
14* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.96149943
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90584663
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90027135
17AR_21572438_ChIP-Seq_LNCaP_Human1.83909954
18* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81438995
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77753700
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77288482
21BCAT_22108803_ChIP-Seq_LS180_Human1.77131964
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.73358184
23TAF15_26573619_Chip-Seq_HEK293_Human1.71414390
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71273730
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67693386
26EWS_26573619_Chip-Seq_HEK293_Human1.66102415
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62555116
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62555116
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60261589
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59483060
31EZH2_22144423_ChIP-Seq_EOC_Human1.57301866
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56007420
33NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55641342
34* TP53_22573176_ChIP-Seq_HFKS_Human1.55462188
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55255863
36FUS_26573619_Chip-Seq_HEK293_Human1.54881177
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52974263
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52833543
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50780840
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49392324
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.47468251
42DROSHA_22980978_ChIP-Seq_HELA_Human1.47387733
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.44988178
44CBP_20019798_ChIP-Seq_JUKART_Human1.42878064
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42878064
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41731191
47* TCF4_23295773_ChIP-Seq_U87_Human1.40577226
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39927795
49SMAD4_21799915_ChIP-Seq_A2780_Human1.39485438
50IRF1_19129219_ChIP-ChIP_H3396_Human1.39387840
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39075136
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38665501
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.37912426
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36781736
55AR_25329375_ChIP-Seq_VCAP_Human1.36630727
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35829520
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35585197
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.34902130
59* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34838052
60NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34801515
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34801515
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33993007
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33993007
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.33624009
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33296117
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.32585265
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31637645
68HTT_18923047_ChIP-ChIP_STHdh_Human1.29833166
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29374224
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28644175
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.28070205
72* FLI1_21867929_ChIP-Seq_TH2_Mouse1.27106952
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26379673
74TCF4_22108803_ChIP-Seq_LS180_Human1.26177920
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25095654
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.24470608
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24285005
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24169169
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.24169169
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23882118
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.23781996
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22959459
83* FOXA2_19822575_ChIP-Seq_HepG2_Human1.22787192
84ER_23166858_ChIP-Seq_MCF-7_Human1.22554492
85GATA3_26560356_Chip-Seq_TH2_Human1.21392906
86FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20916335
87RARB_27405468_Chip-Seq_BRAIN_Mouse1.19885518
88ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18957434
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.17475967
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.17374567
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17349957
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15693859
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15037119
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.14653121
95AR_20517297_ChIP-Seq_VCAP_Human1.14641080
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14507782
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13590440
98E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12949983
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11638667
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.11439754
101RUNX2_22187159_ChIP-Seq_PCA_Human1.09717273
102TP53_16413492_ChIP-PET_HCT116_Human1.09151284
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.09042350
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07947098
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07417260
106PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07071074
107* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06619396
108FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05940163
109RUNX_20019798_ChIP-Seq_JUKART_Human1.05719906
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.05515495
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04510640
112HOXB7_26014856_ChIP-Seq_BT474_Human1.03939042
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03663530
114P53_22387025_ChIP-Seq_ESCs_Mouse1.03459048
115NCOR_22424771_ChIP-Seq_293T_Human1.03220147
116SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02969531
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02614139
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02509269
119CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01834226
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01779104
121OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01702154
122CDX2_22108803_ChIP-Seq_LS180_Human1.01658459
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01149628
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00984939
125WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00241495
126* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99095750
127GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98829378
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97949280
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97779806
130P300_19829295_ChIP-Seq_ESCs_Human0.97663712
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97102833
132* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96737227
133VDR_22108803_ChIP-Seq_LS180_Human0.95897940
134LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94947470
135SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93932528
136ERG_21242973_ChIP-ChIP_JURKAT_Human0.93805724
137REST_21632747_ChIP-Seq_MESCs_Mouse0.93214679
138NANOG_19829295_ChIP-Seq_ESCs_Human0.92430320
139SOX2_19829295_ChIP-Seq_ESCs_Human0.92430320
140REST_18959480_ChIP-ChIP_MESCs_Mouse0.92239442
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91012378
142EOMES_21245162_ChIP-Seq_HESCs_Human0.90596323
143DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89582423
144TAL1_26923725_Chip-Seq_HPCs_Mouse0.88760930
145EP300_21415370_ChIP-Seq_HL-1_Mouse0.87727690
146SMAD4_21741376_ChIP-Seq_EPCs_Human0.87661349
147PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87475504
148FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87356398
149EGR1_19032775_ChIP-ChIP_M12_Human0.87274746
150P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87136783
151PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86360644
152* STAT3_23295773_ChIP-Seq_U87_Human0.85801671
153AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85729129
154SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84606872
155CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84497039
156CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84001376
157GATA1_19941826_ChIP-Seq_K562_Human0.83454798
158BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82414759
159PRDM14_20953172_ChIP-Seq_ESCs_Human0.82211867
160POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80807297
161CBX2_27304074_Chip-Seq_ESCs_Mouse0.79583055
162CMYC_18555785_Chip-Seq_ESCs_Mouse0.79568699
163NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79201437
164* ARNT_22903824_ChIP-Seq_MCF-7_Human0.79031890
165CBP_21632823_ChIP-Seq_H3396_Human0.78974304
166AHR_22903824_ChIP-Seq_MCF-7_Human0.78721379
167NR3C1_23031785_ChIP-Seq_PC12_Mouse0.78634945
168PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.78517012

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.76588646
2MP0002139_abnormal_hepatobiliary_system3.80374645
3MP0005360_urolithiasis3.35400538
4MP0003806_abnormal_nucleotide_metabolis3.28426463
5MP0000372_irregular_coat_pigmentation3.23982588
6MP0003690_abnormal_glial_cell3.15996367
7MP0003950_abnormal_plasma_membrane2.97408056
8MP0003329_amyloid_beta_deposits2.90601779
9MP0000569_abnormal_digit_pigmentation2.79350904
10MP0003880_abnormal_central_pattern2.79174463
11MP0001986_abnormal_taste_sensitivity2.75490614
12MP0009840_abnormal_foam_cell2.73851646
13MP0005085_abnormal_gallbladder_physiolo2.70765998
14MP0003195_calcinosis2.50878831
15MP0002102_abnormal_ear_morphology2.37327017
16MP0005365_abnormal_bile_salt2.33330636
17MP0004270_analgesia2.32142905
18MP0008875_abnormal_xenobiotic_pharmacok2.28544621
19MP0004043_abnormal_pH_regulation2.18682380
20MP0003646_muscle_fatigue2.18569205
21MP0005075_abnormal_melanosome_morpholog2.17649524
22MP0004885_abnormal_endolymph2.17000379
23MP0004142_abnormal_muscle_tone2.15452618
24MP0001529_abnormal_vocalization2.10078733
25MP0008877_abnormal_DNA_methylation2.09075152
26MP0002876_abnormal_thyroid_physiology2.06843063
27MP0001486_abnormal_startle_reflex2.03051417
28MP0005253_abnormal_eye_physiology2.00175236
29MP0002272_abnormal_nervous_system1.99292327
30MP0000604_amyloidosis1.97685816
31MP0005174_abnormal_tail_pigmentation1.95447909
32MP0003634_abnormal_glial_cell1.95137191
33MP0001835_abnormal_antigen_presentation1.87290914
34MP0002064_seizures1.85934697
35MP0006054_spinal_hemorrhage1.85128865
36MP0002837_dystrophic_cardiac_calcinosis1.84731832
37MP0003787_abnormal_imprinting1.84007266
38MP0005451_abnormal_body_composition1.81787557
39MP0003724_increased_susceptibility_to1.77204151
40MP0008872_abnormal_physiological_respon1.73161053
41MP0001968_abnormal_touch/_nociception1.71746436
42MP0005171_absent_coat_pigmentation1.71706210
43MP0000427_abnormal_hair_cycle1.70488312
44MP0005058_abnormal_lysosome_morphology1.66374690
45MP0001905_abnormal_dopamine_level1.63458101
46MP0002229_neurodegeneration1.63097742
47MP0005645_abnormal_hypothalamus_physiol1.62857083
48MP0006276_abnormal_autonomic_nervous1.62487339
49MP0005332_abnormal_amino_acid1.61821446
50MP0006072_abnormal_retinal_apoptosis1.58927064
51MP0005671_abnormal_response_to1.58500577
52MP0004742_abnormal_vestibular_system1.56724030
53MP0003632_abnormal_nervous_system1.56335709
54MP0001984_abnormal_olfaction1.56033188
55MP0005083_abnormal_biliary_tract1.53619806
56MP0005423_abnormal_somatic_nervous1.53479386
57MP0004859_abnormal_synaptic_plasticity1.53310624
58MP0000015_abnormal_ear_pigmentation1.52471167
59MP0003633_abnormal_nervous_system1.51210049
60MP0005409_darkened_coat_color1.49817017
61MP0005646_abnormal_pituitary_gland1.48465587
62MP0003631_nervous_system_phenotype1.47659828
63MP0004381_abnormal_hair_follicle1.45506465
64MP0001666_abnormal_nutrient_absorption1.45335740
65MP0010678_abnormal_skin_adnexa1.44023121
66MP0002118_abnormal_lipid_homeostasis1.43807034
67MP0002638_abnormal_pupillary_reflex1.43298535
68MP0001501_abnormal_sleep_pattern1.40664178
69MP0005410_abnormal_fertilization1.40379745
70MP0003191_abnormal_cellular_cholesterol1.37933393
71MP0003656_abnormal_erythrocyte_physiolo1.36675548
72MP0009745_abnormal_behavioral_response1.34697033
73MP0003878_abnormal_ear_physiology1.32445619
74MP0005377_hearing/vestibular/ear_phenot1.32445619
75MP0001485_abnormal_pinna_reflex1.30733094
76MP0003635_abnormal_synaptic_transmissio1.30364562
77MP0002822_catalepsy1.30099894
78MP0003252_abnormal_bile_duct1.28388032
79MP0008260_abnormal_autophagy1.28312545
80MP0005551_abnormal_eye_electrophysiolog1.26016835
81MP0005084_abnormal_gallbladder_morpholo1.25492920
82MP0009046_muscle_twitch1.23630419
83MP0000778_abnormal_nervous_system1.22975163
84MP0005584_abnormal_enzyme/coenzyme_acti1.22703520
85MP0003011_delayed_dark_adaptation1.22501144
86MP0002095_abnormal_skin_pigmentation1.21139522
87MP0010329_abnormal_lipoprotein_level1.20899148
88MP0002928_abnormal_bile_duct1.20578625
89MP0003136_yellow_coat_color1.20361297
90MP0002736_abnormal_nociception_after1.13344759
91MP0002938_white_spotting1.13133365
92MP0009764_decreased_sensitivity_to1.13078234
93MP0006082_CNS_inflammation1.12745758
94MP0004484_altered_response_of1.12157457
95MP0001324_abnormal_eye_pigmentation1.11585984
96MP0000383_abnormal_hair_follicle1.10092796
97MP0001800_abnormal_humoral_immune1.09448911
98MP0003075_altered_response_to1.09217688
99MP0002138_abnormal_hepatobiliary_system1.08319658
100MP0005408_hypopigmentation1.07850085
101MP0002277_abnormal_respiratory_mucosa1.06358191
102MP0002163_abnormal_gland_morphology1.06184939
103MP0002148_abnormal_hypersensitivity_rea1.04904779
104MP0000371_diluted_coat_color1.04580535
105MP0005310_abnormal_salivary_gland1.03189237
106MP0002734_abnormal_mechanical_nocicepti1.01545082
107MP0000955_abnormal_spinal_cord1.01368173
108MP0000566_synostosis1.00882609
109MP0000747_muscle_weakness0.99851971
110MP0002653_abnormal_ependyma_morphology0.99429134
111MP0002557_abnormal_social/conspecific_i0.99426765
112MP0004019_abnormal_vitamin_homeostasis0.99345973
113MP0002063_abnormal_learning/memory/cond0.97458173
114MP0002572_abnormal_emotion/affect_behav0.97441251
115MP0001919_abnormal_reproductive_system0.97419700
116MP0002066_abnormal_motor_capabilities/c0.97136735
117MP0009785_altered_susceptibility_to0.96326641
118MP0005379_endocrine/exocrine_gland_phen0.94964109
119MP0003122_maternal_imprinting0.94830283
120MP0005387_immune_system_phenotype0.93582882
121MP0001790_abnormal_immune_system0.93582882
122MP0000579_abnormal_nail_morphology0.91094019
123MP0002254_reproductive_system_inflammat0.91003893
124MP0001177_atelectasis0.90731257
125MP0000462_abnormal_digestive_system0.90565559
126MP0002723_abnormal_immune_serum0.90223865
127MP0002735_abnormal_chemical_nociception0.89995255
128MP0002909_abnormal_adrenal_gland0.89420661
129MP0008569_lethality_at_weaning0.89031054
130MP0002693_abnormal_pancreas_physiology0.88093806
131MP0001970_abnormal_pain_threshold0.87605798
132MP0004134_abnormal_chest_morphology0.87566692
133MP0005389_reproductive_system_phenotype0.87474745
134MP0005167_abnormal_blood-brain_barrier0.87417108
135MP0010386_abnormal_urinary_bladder0.87156812
136MP0002882_abnormal_neuron_morphology0.85790226
137MP0001440_abnormal_grooming_behavior0.85653494
138MP0001346_abnormal_lacrimal_gland0.85314065
139MP0004147_increased_porphyrin_level0.84371170
140MP0000639_abnormal_adrenal_gland0.83546853
141MP0002452_abnormal_antigen_presenting0.83462819
142MP0000647_abnormal_sebaceous_gland0.82887965
143MP0000631_abnormal_neuroendocrine_gland0.81699424
144MP0000685_abnormal_immune_system0.81034823
145MP0002090_abnormal_vision0.80771625
146MP0002420_abnormal_adaptive_immunity0.80479180
147MP0005386_behavior/neurological_phenoty0.80399649
148MP0004924_abnormal_behavior0.80399649
149MP0000230_abnormal_systemic_arterial0.80195504
150MP0002067_abnormal_sensory_capabilities0.79504671
151MP0001963_abnormal_hearing_physiology0.78959814
152MP0001819_abnormal_immune_cell0.78497293
153MP0003137_abnormal_impulse_conducting0.76651643
154MP0001851_eye_inflammation0.75879859
155MP0005195_abnormal_posterior_eye0.75282514
156MP0002295_abnormal_pulmonary_circulatio0.74625992
157MP0008874_decreased_physiological_sensi0.69298119
158MP0000003_abnormal_adipose_tissue0.68171448
159MP0002752_abnormal_somatic_nervous0.64833184
160MP0005535_abnormal_body_temperature0.64793068
161MP0001661_extended_life_span0.63904731
162MP0009765_abnormal_xenobiotic_induced0.62948742
163MP0002733_abnormal_thermal_nociception0.62172498
164MP0001764_abnormal_homeostasis0.61449475
165MP0001299_abnormal_eye_distance/0.60268353
166MP0003868_abnormal_feces_composition0.59862665
167MP0003186_abnormal_redox_activity0.58433727

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.06988217
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.37511294
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.37511294
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.15636786
5Cerebral inclusion bodies (HP:0100314)4.52348818
6Congenital stationary night blindness (HP:0007642)4.27019807
7Pancreatic cysts (HP:0001737)4.18491803
8Abnormality of the corticospinal tract (HP:0002492)4.15257956
9Intrahepatic cholestasis (HP:0001406)3.92879895
10Hypothermia (HP:0002045)3.87110497
11Peripheral hypomyelination (HP:0007182)3.67414545
12Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.63294585
13Onion bulb formation (HP:0003383)3.60898454
14Abnormal rod and cone electroretinograms (HP:0008323)3.59839627
15Cerebral hypomyelination (HP:0006808)3.59009014
16Decreased central vision (HP:0007663)3.57766896
17Abnormality of midbrain morphology (HP:0002418)3.54825514
18Molar tooth sign on MRI (HP:0002419)3.54825514
19Supranuclear gaze palsy (HP:0000605)3.52914180
20Pancreatic fibrosis (HP:0100732)3.50915296
21Parakeratosis (HP:0001036)3.48570173
22True hermaphroditism (HP:0010459)3.47104026
23Attenuation of retinal blood vessels (HP:0007843)3.38960687
24Xanthomatosis (HP:0000991)3.31376216
25Hyperventilation (HP:0002883)3.31187280
26Hyperlipoproteinemia (HP:0010980)3.27519961
27Sensory axonal neuropathy (HP:0003390)3.25263809
28Absent rod-and cone-mediated responses on ERG (HP:0007688)3.21040876
29Spastic gait (HP:0002064)3.15424993
30Nephronophthisis (HP:0000090)3.14337524
31Abnormal auditory evoked potentials (HP:0006958)3.12764060
32Abnormality of the renal cortex (HP:0011035)3.12371318
33Termporal pattern (HP:0011008)3.11333598
34Insidious onset (HP:0003587)3.11333598
35Deep venous thrombosis (HP:0002625)3.10477810
36Stomatitis (HP:0010280)3.10409410
37Intention tremor (HP:0002080)3.08921401
38Axonal loss (HP:0003447)3.01563330
39Medial flaring of the eyebrow (HP:0010747)2.98942086
40Type II lissencephaly (HP:0007260)2.93642856
41Leukodystrophy (HP:0002415)2.91470010
42Chronic otitis media (HP:0000389)2.88583808
43Abolished electroretinogram (ERG) (HP:0000550)2.86697971
44Spastic tetraparesis (HP:0001285)2.84486443
45Abnormality of the renal medulla (HP:0100957)2.80704242
46Dysmetria (HP:0001310)2.78879750
47Spastic paraparesis (HP:0002313)2.77929359
48Increased corneal curvature (HP:0100692)2.76629177
49Keratoconus (HP:0000563)2.76629177
50Ankle clonus (HP:0011448)2.76552977
51Gaze-evoked nystagmus (HP:0000640)2.75494511
52Myokymia (HP:0002411)2.74972431
53Bony spicule pigmentary retinopathy (HP:0007737)2.71305791
54Segmental peripheral demyelination/remyelination (HP:0003481)2.69547302
55Prolonged partial thromboplastin time (HP:0003645)2.68826975
56Slow saccadic eye movements (HP:0000514)2.66080290
57Alacrima (HP:0000522)2.65839981
58Scanning speech (HP:0002168)2.61507289
59Chronic hepatic failure (HP:0100626)2.57516699
60Increased serum pyruvate (HP:0003542)2.57437494
61Abnormality of glycolysis (HP:0004366)2.57437494
62Cerebral hemorrhage (HP:0001342)2.54434583
63Abnormality of methionine metabolism (HP:0010901)2.52687448
64Clumsiness (HP:0002312)2.49822746
65Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.48038457
66Paraparesis (HP:0002385)2.47765954
67Decreased electroretinogram (ERG) amplitude (HP:0000654)2.46987683
68Congenital sensorineural hearing impairment (HP:0008527)2.46424028
69Genetic anticipation (HP:0003743)2.45782846
70Hypophosphatemic rickets (HP:0004912)2.44823984
71Gait imbalance (HP:0002141)2.42302237
72Progressive inability to walk (HP:0002505)2.41606441
73Complement deficiency (HP:0004431)2.41137211
74Abnormality of aspartate family amino acid metabolism (HP:0010899)2.38786221
75Polydipsia (HP:0001959)2.38529999
76Abnormal drinking behavior (HP:0030082)2.38529999
77Metabolic alkalosis (HP:0200114)2.37446828
78Stomach cancer (HP:0012126)2.36614806
79Increased circulating renin level (HP:0000848)2.35773115
80Peripheral demyelination (HP:0011096)2.35374869
81Congenital primary aphakia (HP:0007707)2.34422111
82Progressive cerebellar ataxia (HP:0002073)2.33498582
83Inability to walk (HP:0002540)2.32398496
84Lissencephaly (HP:0001339)2.32187860
85Retrobulbar optic neuritis (HP:0100654)2.31771416
86Optic neuritis (HP:0100653)2.31771416
87Retinal dysplasia (HP:0007973)2.31125946
88Pendular nystagmus (HP:0012043)2.30236451
89Tubular atrophy (HP:0000092)2.29973509
90Cystic liver disease (HP:0006706)2.29742786
91CNS hypomyelination (HP:0003429)2.29609602
92Renal cortical cysts (HP:0000803)2.28744910
93Hypokalemic alkalosis (HP:0001949)2.28365436
94Abnormal gallbladder physiology (HP:0012438)2.27655342
95Cholecystitis (HP:0001082)2.27655342
96Vascular calcification (HP:0004934)2.25336773
97Thyroiditis (HP:0100646)2.24748761
98Nephrogenic diabetes insipidus (HP:0009806)2.23608662
99Pheochromocytoma (HP:0002666)2.23260358
100Constricted visual fields (HP:0001133)2.22818714
101Abnormality of glycine metabolism (HP:0010895)2.22419781
102Abnormality of serine family amino acid metabolism (HP:0010894)2.22419781
103Amyloidosis (HP:0011034)2.22099044
104Stridor (HP:0010307)2.21772999
105Fat malabsorption (HP:0002630)2.21647023
106Aplasia/Hypoplasia of the fovea (HP:0008060)2.16655412
107Hypoplasia of the fovea (HP:0007750)2.16655412
108Choreoathetosis (HP:0001266)2.13107047
109Elevated erythrocyte sedimentation rate (HP:0003565)2.11177092
110Abnormality of macular pigmentation (HP:0008002)2.10861951
111Cerebellar dysplasia (HP:0007033)2.10830985
112Split foot (HP:0001839)2.10637042
113Hepatosplenomegaly (HP:0001433)2.10557160
114Large for gestational age (HP:0001520)2.10194889
115Abnormality of monocarboxylic acid metabolism (HP:0010996)2.09996999
116Hemiparesis (HP:0001269)2.09653021
117Epidermoid cyst (HP:0200040)2.08531854
118Premature skin wrinkling (HP:0100678)2.08008487
119Chronic sinusitis (HP:0011109)2.07311105
120Decreased lacrimation (HP:0000633)2.05860732
121Abnormal delayed hypersensitivity skin test (HP:0002963)2.05389770
122Anteriorly placed anus (HP:0001545)2.04593678
123Generalized hypopigmentation of hair (HP:0011358)2.02550726
124Intestinal atresia (HP:0011100)2.00480359
125Poor speech (HP:0002465)2.00113014
126Broad-based gait (HP:0002136)1.98628613
127Hyperammonemia (HP:0001987)1.98561767
128Steatorrhea (HP:0002570)1.98508181
129Hypobetalipoproteinemia (HP:0003563)1.97560196
130Clonus (HP:0002169)1.97117516
131Fair hair (HP:0002286)1.96413609
132Urinary incontinence (HP:0000020)1.95490964
133Turricephaly (HP:0000262)1.95455570
134Lower limb muscle weakness (HP:0007340)1.95016367
135Orchitis (HP:0100796)1.94895937
136Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94852819
137Abnormality of alanine metabolism (HP:0010916)1.94852819
138Hyperalaninemia (HP:0003348)1.94852819
139Abnormality of the fovea (HP:0000493)1.94270413
140Neuronal loss in central nervous system (HP:0002529)1.94029848
141Urinary urgency (HP:0000012)1.93616853
142Cardiovascular calcification (HP:0011915)1.92964607
143Absent speech (HP:0001344)1.92295503
144Aplasia/Hypoplasia of the tongue (HP:0010295)1.92179115
145Thickened helices (HP:0000391)1.91940655
146Congenital ichthyosiform erythroderma (HP:0007431)1.91558298
147Systemic lupus erythematosus (HP:0002725)1.91153081
148Ketosis (HP:0001946)1.90916937
149Morphological abnormality of the pyramidal tract (HP:0002062)1.90104577
150Coronal craniosynostosis (HP:0004440)1.89194411
151Polyuria (HP:0000103)1.89149534
152Congenital hepatic fibrosis (HP:0002612)1.89048851
153Aplasia involving bones of the upper limbs (HP:0009823)1.88638025
154Aplasia of the phalanges of the hand (HP:0009802)1.88638025
155Aplasia involving bones of the extremities (HP:0009825)1.88638025
156Ketoacidosis (HP:0001993)1.88145762
157Torticollis (HP:0000473)1.88126733
158Macular degeneration (HP:0000608)1.88061475
159Confusion (HP:0001289)1.87597437
160Febrile seizures (HP:0002373)1.87445703
161Agitation (HP:0000713)1.86093030
162Foot dorsiflexor weakness (HP:0009027)1.85993124
163Hypoproteinemia (HP:0003075)1.84821716
164Aplasia/Hypoplasia of the tibia (HP:0005772)1.84638623
165Genital tract atresia (HP:0001827)1.84304446
166Postaxial foot polydactyly (HP:0001830)1.83733406
167Myositis (HP:0100614)1.83210295
168Pachygyria (HP:0001302)1.82824926
169Severe visual impairment (HP:0001141)1.82541012
170Megalencephaly (HP:0001355)1.82527879
171Furrowed tongue (HP:0000221)1.82253687
172Abnormality of sulfur amino acid metabolism (HP:0004339)1.82153067
173Loss of speech (HP:0002371)1.82009633
174White forelock (HP:0002211)1.81660445
175Neuroendocrine neoplasm (HP:0100634)1.81199684
176Albinism (HP:0001022)1.81012089
177Progressive neurologic deterioration (HP:0002344)1.80137844
178Retinitis pigmentosa (HP:0000510)1.79303815
179Sclerocornea (HP:0000647)1.79106170
180Disproportionate short-trunk short stature (HP:0003521)1.78463778
181Abnormality of the phalanges of the 2nd finger (HP:0009541)1.77952823
182Increased CSF lactate (HP:0002490)1.77947589
183Patchy hypopigmentation of hair (HP:0011365)1.77812584
184Action tremor (HP:0002345)1.77380003
185Decreased motor nerve conduction velocity (HP:0003431)1.77273092
186Vaginal atresia (HP:0000148)1.74876782
187Photophobia (HP:0000613)1.74175914
188Widely spaced teeth (HP:0000687)1.74162559
189Chorioretinal atrophy (HP:0000533)1.73804589
190Anencephaly (HP:0002323)1.72903156
191Mitochondrial inheritance (HP:0001427)1.71297063
192Hypoplasia of the pons (HP:0012110)1.70844895
193Male pseudohermaphroditism (HP:0000037)1.69285937
194Decreased circulating renin level (HP:0003351)1.69226540
195Abnormality of the pons (HP:0007361)1.67653530
196Progressive macrocephaly (HP:0004481)1.67037849
197Hematochezia (HP:0002573)1.66998136
198Recurrent bronchitis (HP:0002837)1.66243283
1993-Methylglutaconic aciduria (HP:0003535)1.64411370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.40568714
2STK395.95130783
3OXSR14.42011500
4EPHB14.12172494
5ADRBK23.11615976
6BMPR1B3.06062032
7TAOK32.96822924
8MAP4K22.95274307
9MAPKAPK52.87580201
10PKN12.84825178
11TLK12.83025134
12FGFR22.82099443
13WNK42.75892645
14TXK2.49047631
15MET2.35472372
16ACVR1B2.35074684
17PBK2.14554020
18NUAK12.01137109
19CDK192.00303148
20BCR1.89285885
21ZAK1.80497919
22TESK21.78914125
23WNK11.74465710
24CAMK2B1.73457709
25NTRK11.68409161
26SGK2231.66629472
27SGK4941.66629472
28TRIM281.65620965
29LIMK11.64077119
30CSNK1G31.58289215
31UHMK11.57768189
32MAPK131.57545905
33CSNK1A1L1.48296442
34PAK61.45836789
35CAMK2D1.37386396
36EPHA41.37101242
37ROCK21.33382297
38TNIK1.32057180
39CSNK1G11.32037235
40CAMK2G1.29346822
41CSNK1G21.24985760
42TNK21.22674601
43BMPR21.17315651
44NEK61.17153774
45MAPK151.14905080
46FGR1.14817953
47CLK11.12188655
48MAP3K41.11859980
49ADRBK11.11790606
50MAP2K61.10340385
51PNCK1.07946301
52MAP3K131.05058629
53IKBKB1.05029173
54FER1.05019142
55CASK1.04983640
56PLK21.00620763
57NLK0.98805488
58GRK60.96700680
59DYRK20.94837244
60BCKDK0.93862401
61CAMK1G0.91833954
62PRKD10.91459067
63PRKCQ0.91278859
64STK38L0.91025363
65PDPK10.90902832
66PINK10.89565436
67MARK20.89505039
68FES0.88380917
69KSR20.86678399
70CDK50.86561278
71ICK0.85067483
72CAMK2A0.85029672
73ERBB30.84753050
74PHKG20.82632977
75PHKG10.82632977
76ERBB40.81399957
77PAK30.79540900
78TYRO30.78021214
79MAP4K10.77985004
80MARK10.77402769
81TEC0.76300140
82GSK3A0.74318107
83IRAK10.71063767
84PRKCH0.70172706
85CHUK0.70117658
86CAMKK20.69293120
87EPHA30.69067973
88MST40.69067174
89PIK3CA0.68491422
90GRK70.68437648
91DAPK20.67161855
92MKNK20.67115355
93CDK140.66569029
94AKT30.65490887
95SYK0.65112937
96CDK150.64338513
97TGFBR10.63672525
98PRKD30.62365533
99PRKCE0.61908817
100ARAF0.60274518
101STK110.57626793
102CDK180.57217323
103MAP2K70.56914061
104PRKCG0.55960918
105FYN0.55773012
106PDK10.55694601
107CAMK1D0.55013752
108CDK11A0.54159253
109PRKAA20.53840311
110MST1R0.53713158
111MAPK70.52831366
112INSRR0.51807501
113BMX0.51554867
114LYN0.51135517
115PRPF4B0.50806719
116KIT0.49832041
117PRKG10.48771139
118HCK0.47649995
119MAP2K20.47385730
120PRKACB0.47385363
121PRKCZ0.46605268
122BLK0.45853024
123SIK30.45627246
124NTRK20.45303759
125MAPK120.44114351
126PTK2B0.44100191
127DAPK30.42891493
128MAP3K90.42585176
129LCK0.41893340
130CSNK1D0.41334335
131BTK0.41040853
132CSNK1A10.40955407
133IKBKE0.40663332
134IRAK20.39932775
135MAP3K20.39591756
136VRK10.39498842
137EIF2AK30.39479183
138MARK30.39033912
139SIK10.38609007
140MAP3K120.37871396
141SGK20.35308870
142PIK3CG0.34823382
143OBSCN0.34716944
144CAMK10.34430164
145GRK10.34091800
146STK30.33883963
147CSF1R0.33532155
148ABL10.32005152
149JAK10.31986255
150TRPM70.31724430
151PRKACA0.31660050
152TAF10.31602063
153WNK30.31382361
154ITK0.31321174
155GRK50.30855355
156TIE10.30396639
157RET0.30154258
158MUSK0.30059748
159IRAK40.29583409
160MAP3K70.28600777
161NTRK30.28582685

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.01945752
2Fatty acid elongation_Homo sapiens_hsa000623.72397510
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.41917055
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.32886617
5Steroid biosynthesis_Homo sapiens_hsa001003.22671399
6Phototransduction_Homo sapiens_hsa047443.04103649
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.93480624
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.65326634
9Histidine metabolism_Homo sapiens_hsa003402.43129813
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.34044167
11Butanoate metabolism_Homo sapiens_hsa006502.25292298
12Sulfur metabolism_Homo sapiens_hsa009202.08891130
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.05876140
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.97867952
15Vitamin B6 metabolism_Homo sapiens_hsa007501.96131987
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95536313
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.95236342
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.93872869
19Selenocompound metabolism_Homo sapiens_hsa004501.82285731
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80551861
21Homologous recombination_Homo sapiens_hsa034401.80434447
22Ether lipid metabolism_Homo sapiens_hsa005651.78089203
23Arginine biosynthesis_Homo sapiens_hsa002201.68408372
24Propanoate metabolism_Homo sapiens_hsa006401.66975098
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64368956
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63780748
27Primary immunodeficiency_Homo sapiens_hsa053401.60005008
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56939254
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.55823819
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51522213
31Peroxisome_Homo sapiens_hsa041461.51160913
32Fatty acid metabolism_Homo sapiens_hsa012121.49925691
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46324774
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.43833583
35Regulation of autophagy_Homo sapiens_hsa041401.43373448
36Complement and coagulation cascades_Homo sapiens_hsa046101.39129986
37Tryptophan metabolism_Homo sapiens_hsa003801.33382511
38Basal transcription factors_Homo sapiens_hsa030221.32085728
39Arginine and proline metabolism_Homo sapiens_hsa003301.29867985
40Folate biosynthesis_Homo sapiens_hsa007901.29550325
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25483684
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23686803
43Chemical carcinogenesis_Homo sapiens_hsa052041.22908015
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22398412
45Olfactory transduction_Homo sapiens_hsa047401.22110493
46Fatty acid degradation_Homo sapiens_hsa000711.21845562
47Linoleic acid metabolism_Homo sapiens_hsa005911.19863295
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.18498110
49beta-Alanine metabolism_Homo sapiens_hsa004101.18404456
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14049944
51Retinol metabolism_Homo sapiens_hsa008301.11493531
52Bile secretion_Homo sapiens_hsa049761.10969171
53Type I diabetes mellitus_Homo sapiens_hsa049401.10540132
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09289821
55Tyrosine metabolism_Homo sapiens_hsa003501.07955545
56Graft-versus-host disease_Homo sapiens_hsa053321.07621346
57Vitamin digestion and absorption_Homo sapiens_hsa049771.07576985
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06176115
59PPAR signaling pathway_Homo sapiens_hsa033201.05100535
60Taste transduction_Homo sapiens_hsa047421.03422376
61Staphylococcus aureus infection_Homo sapiens_hsa051501.00882739
62Fanconi anemia pathway_Homo sapiens_hsa034601.00795088
63Allograft rejection_Homo sapiens_hsa053300.97542535
64Nicotine addiction_Homo sapiens_hsa050330.95968525
65Dorso-ventral axis formation_Homo sapiens_hsa043200.95536509
66Autoimmune thyroid disease_Homo sapiens_hsa053200.95350727
67Asthma_Homo sapiens_hsa053100.93810316
68Rheumatoid arthritis_Homo sapiens_hsa053230.93390617
69Pyruvate metabolism_Homo sapiens_hsa006200.93302975
70Circadian rhythm_Homo sapiens_hsa047100.89544193
71GABAergic synapse_Homo sapiens_hsa047270.88501463
72Sphingolipid metabolism_Homo sapiens_hsa006000.88074499
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87922142
74ABC transporters_Homo sapiens_hsa020100.85501300
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79675227
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78059716
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77785871
78RNA polymerase_Homo sapiens_hsa030200.77779685
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74712836
80Phenylalanine metabolism_Homo sapiens_hsa003600.74159226
81Glutathione metabolism_Homo sapiens_hsa004800.73739217
82Insulin secretion_Homo sapiens_hsa049110.73450374
83Fat digestion and absorption_Homo sapiens_hsa049750.72097462
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69970088
85Protein export_Homo sapiens_hsa030600.68845594
86Hematopoietic cell lineage_Homo sapiens_hsa046400.68245580
87Glutamatergic synapse_Homo sapiens_hsa047240.67639745
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65199198
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.65052528
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.63957907
91Axon guidance_Homo sapiens_hsa043600.63739258
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62882535
93Calcium signaling pathway_Homo sapiens_hsa040200.61926368
94Oxidative phosphorylation_Homo sapiens_hsa001900.61112776
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60572360
96Cocaine addiction_Homo sapiens_hsa050300.58456964
97Glycerolipid metabolism_Homo sapiens_hsa005610.56953467
98RNA degradation_Homo sapiens_hsa030180.56502312
99Prion diseases_Homo sapiens_hsa050200.54688305
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54387895
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.54173126
102T cell receptor signaling pathway_Homo sapiens_hsa046600.53999334
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.53054080
104Dopaminergic synapse_Homo sapiens_hsa047280.51917893
105Arachidonic acid metabolism_Homo sapiens_hsa005900.51697779
106Morphine addiction_Homo sapiens_hsa050320.51651078
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51414346
108Caffeine metabolism_Homo sapiens_hsa002320.50204222
109* Lysosome_Homo sapiens_hsa041420.49746985
110One carbon pool by folate_Homo sapiens_hsa006700.49489785
111Huntingtons disease_Homo sapiens_hsa050160.49298596
112Serotonergic synapse_Homo sapiens_hsa047260.48392016
113Metabolic pathways_Homo sapiens_hsa011000.47519648
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.45150463
115Collecting duct acid secretion_Homo sapiens_hsa049660.43057144
116Starch and sucrose metabolism_Homo sapiens_hsa005000.42911150
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42557896
118Renal cell carcinoma_Homo sapiens_hsa052110.41776685
119Fatty acid biosynthesis_Homo sapiens_hsa000610.41240843
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.40621672
121Mineral absorption_Homo sapiens_hsa049780.40539531
122Osteoclast differentiation_Homo sapiens_hsa043800.40519973
123Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40487976
124Alzheimers disease_Homo sapiens_hsa050100.40384819
125Biosynthesis of amino acids_Homo sapiens_hsa012300.38222728
126Ovarian steroidogenesis_Homo sapiens_hsa049130.37992469
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37487951
128Gastric acid secretion_Homo sapiens_hsa049710.36988157
129Long-term depression_Homo sapiens_hsa047300.36689586
130Parkinsons disease_Homo sapiens_hsa050120.36637367
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35868008
132Cholinergic synapse_Homo sapiens_hsa047250.35126444
133Salivary secretion_Homo sapiens_hsa049700.34283494
134Purine metabolism_Homo sapiens_hsa002300.33719014
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.33529437
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33395969
137Vibrio cholerae infection_Homo sapiens_hsa051100.32810781
138Chemokine signaling pathway_Homo sapiens_hsa040620.32741888
139Carbon metabolism_Homo sapiens_hsa012000.32228747
140Pancreatic secretion_Homo sapiens_hsa049720.30388560
141Circadian entrainment_Homo sapiens_hsa047130.29836629
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28006022
143Synaptic vesicle cycle_Homo sapiens_hsa047210.27644565
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24342768
145Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23429775
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.21756682
1472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21646938
148Drug metabolism - other enzymes_Homo sapiens_hsa009830.21231370

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