ARSH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sulfatases, such as ARSH, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)9.41491598
2regulation of acrosome reaction (GO:0060046)8.65714554
3sphingosine metabolic process (GO:0006670)8.36571055
4regulation of protein glycosylation (GO:0060049)8.22341301
5positive regulation of cAMP-mediated signaling (GO:0043950)7.91220735
6negative regulation of nitric oxide biosynthetic process (GO:0045019)7.68858231
7diol metabolic process (GO:0034311)7.65339991
8piRNA metabolic process (GO:0034587)7.30844111
9sphingoid metabolic process (GO:0046519)7.02293716
10thrombin receptor signaling pathway (GO:0070493)6.83580143
11glycerol ether metabolic process (GO:0006662)6.69330031
12negative regulation of glycoprotein biosynthetic process (GO:0010561)6.63645037
13notochord development (GO:0030903)6.61720975
14ether metabolic process (GO:0018904)6.18253297
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.64963055
16cellular response to ammonium ion (GO:0071242)5.59780994
17regulation of glutamate receptor signaling pathway (GO:1900449)5.54376751
18mRNA cleavage (GO:0006379)5.53201935
19DNA replication-dependent nucleosome assembly (GO:0006335)5.52468619
20DNA replication-dependent nucleosome organization (GO:0034723)5.52468619
21signal complex assembly (GO:0007172)5.37474917
22regulation of cAMP-mediated signaling (GO:0043949)5.19847409
23pyrimidine dimer repair (GO:0006290)5.12222010
24negative regulation of glycoprotein metabolic process (GO:1903019)4.89343464
25ncRNA catabolic process (GO:0034661)4.80102711
26negative regulation of cell-matrix adhesion (GO:0001953)4.63868237
27cellular response to alkaloid (GO:0071312)4.34123164
28regulation of translational elongation (GO:0006448)4.24577603
29regulation of female receptivity (GO:0045924)4.24514035
30negative regulation of adenylate cyclase activity (GO:0007194)4.15213423
31glomerular visceral epithelial cell development (GO:0072015)4.09068743
32regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.04631965
33negative regulation of exocytosis (GO:0045920)3.95842230
34negative regulation of cyclase activity (GO:0031280)3.95375789
35N-terminal protein amino acid acetylation (GO:0006474)3.88764921
36cell-cell junction maintenance (GO:0045217)3.87880369
37coenzyme catabolic process (GO:0009109)3.86506839
38vitamin catabolic process (GO:0009111)3.82796500
39fat-soluble vitamin catabolic process (GO:0042363)3.82796500
40negative regulation of lyase activity (GO:0051350)3.73164760
41female mating behavior (GO:0060180)3.71276367
42DNA synthesis involved in DNA repair (GO:0000731)3.68914537
43glomerular epithelial cell development (GO:0072310)3.58352897
44cornea development in camera-type eye (GO:0061303)3.52831631
45regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.48324970
46response to morphine (GO:0043278)3.46549292
47chemical homeostasis within a tissue (GO:0048875)3.40038259
48omega-hydroxylase P450 pathway (GO:0097267)3.33152360
49dopamine receptor signaling pathway (GO:0007212)3.31633854
50response to isoquinoline alkaloid (GO:0014072)3.29853590
51wound healing, spreading of epidermal cells (GO:0035313)3.26920647
52positive regulation of cholesterol efflux (GO:0010875)3.25275389
53regulation of memory T cell differentiation (GO:0043380)3.21377345
54positive regulation of nitric oxide biosynthetic process (GO:0045429)3.21215320
55regulation of odontogenesis (GO:0042481)3.21083833
56RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.18298438
57smooth muscle tissue development (GO:0048745)3.17972028
58positive regulation of protein complex disassembly (GO:0043243)3.08573352
59regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.08373750
60thyroid hormone generation (GO:0006590)3.08030265
61detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.03805087
62surfactant homeostasis (GO:0043129)3.00741464
63regulation of calcium ion-dependent exocytosis (GO:0017158)2.99395595
64cell junction maintenance (GO:0034331)2.97553388
65positive regulation of cardiac muscle cell differentiation (GO:2000727)2.97546938
66positive regulation of icosanoid secretion (GO:0032305)2.96922657
67polyol biosynthetic process (GO:0046173)2.94848504
68positive regulation of fatty acid transport (GO:2000193)2.94459475
69positive regulation of cholesterol transport (GO:0032376)2.92839532
70positive regulation of sterol transport (GO:0032373)2.92839532
71negative regulation of cAMP biosynthetic process (GO:0030818)2.91318662
72regulation of cytokine production involved in inflammatory response (GO:1900015)2.90581512
73neuronal action potential (GO:0019228)2.89091224
74left/right axis specification (GO:0070986)2.88344336
75membrane depolarization during action potential (GO:0086010)2.83873525
76negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.80312148
77regulation of glycoprotein biosynthetic process (GO:0010559)2.79758386
78establishment of skin barrier (GO:0061436)2.78089089
79glomerular basement membrane development (GO:0032836)2.78038857
80sensory perception of pain (GO:0019233)2.76296193
81thyroid hormone metabolic process (GO:0042403)2.75840335
82response to caffeine (GO:0031000)2.71266783
83spermatid development (GO:0007286)2.68439431
84glucose catabolic process (GO:0006007)2.66241321
85negative regulation of cell-substrate adhesion (GO:0010812)2.64970509
86replication fork processing (GO:0031297)2.64256302
87negative regulation of purine nucleotide biosynthetic process (GO:1900372)2.64071044
88negative regulation of nucleotide biosynthetic process (GO:0030809)2.64071044
89viral mRNA export from host cell nucleus (GO:0046784)2.61756049
90gene silencing by RNA (GO:0031047)2.60891047
91preassembly of GPI anchor in ER membrane (GO:0016254)2.57655958
92detection of mechanical stimulus (GO:0050982)2.56308672
93negative regulation of cytosolic calcium ion concentration (GO:0051481)16.1674917
94negative regulation of cAMP-mediated signaling (GO:0043951)13.8044537
95opioid receptor signaling pathway (GO:0038003)12.2716631
96ether lipid metabolic process (GO:0046485)11.5660824
97regulation of translational termination (GO:0006449)11.2794098
98negative regulation of calcium ion-dependent exocytosis (GO:0045955)10.9430937
99behavioral response to ethanol (GO:0048149)10.9118949
100adult feeding behavior (GO:0008343)10.2454967

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.52297747
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse4.32015376
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.49926451
4VDR_22108803_ChIP-Seq_LS180_Human3.47318477
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.21702742
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.19369156
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse3.19369156
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.00088671
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.88478075
10RXR_22108803_ChIP-Seq_LS180_Human2.81110540
11EGR1_19032775_ChIP-ChIP_M12_Human2.60602581
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.58067417
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34530969
14TAF15_26573619_Chip-Seq_HEK293_Human2.30293810
15HTT_18923047_ChIP-ChIP_STHdh_Human2.16467022
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08519198
17GBX2_23144817_ChIP-Seq_PC3_Human1.93887255
18SUZ12_27294783_Chip-Seq_NPCs_Mouse1.93558154
19PCGF2_27294783_Chip-Seq_NPCs_Mouse1.92350679
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91551926
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90463091
22SOX2_19829295_ChIP-Seq_ESCs_Human1.88155071
23NANOG_19829295_ChIP-Seq_ESCs_Human1.88155071
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.86987586
25BCAT_22108803_ChIP-Seq_LS180_Human1.82163628
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.79447774
27CBP_20019798_ChIP-Seq_JUKART_Human1.79447774
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.71394212
29ZNF274_21170338_ChIP-Seq_K562_Hela1.60770350
30TCF4_23295773_ChIP-Seq_U87_Human1.57353171
31IRF1_19129219_ChIP-ChIP_H3396_Human1.54377810
32CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51052718
33NANOG_20526341_ChIP-Seq_ESCs_Human1.50442066
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.47352685
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45597815
36SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.44333157
37TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.44245122
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.43973314
39PKCTHETA_26484144_Chip-Seq_BREAST_Human1.43266055
40STAT3_23295773_ChIP-Seq_U87_Human1.41961089
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40152508
42DROSHA_22980978_ChIP-Seq_HELA_Human1.39451096
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32937804
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30906199
45PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.29356136
46CDX2_22108803_ChIP-Seq_LS180_Human1.29172435
47FLI1_21867929_ChIP-Seq_TH2_Mouse1.28211216
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28119014
49CRX_20693478_ChIP-Seq_RETINA_Mouse1.27438752
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23965266
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.20155808
52TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19051150
53TP53_18474530_ChIP-ChIP_U2OS_Human1.19013116
54FOXH1_21741376_ChIP-Seq_ESCs_Human1.16914385
55CEBPB_22108803_ChIP-Seq_LS180_Human1.14421663
56OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13333253
57TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13198904
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.12962686
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12774367
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12719516
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.12137222
62RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11583758
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11232946
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10657160
65MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09269160
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08081302
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07294142
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06310468
69SCL_19346495_ChIP-Seq_HPC-7_Human1.05760854
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.05436905
71SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03995693
72LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03262340
73AR_25329375_ChIP-Seq_VCAP_Human1.02497886
74AR_21909140_ChIP-Seq_LNCAP_Human1.02061880
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00923585
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00835486
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.00541478
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00154929
79KDM2B_26808549_Chip-Seq_REH_Human1.00068661
80OCT1_27270436_Chip-Seq_PROSTATE_Human0.99120205
81PIAS1_25552417_ChIP-Seq_VCAP_Human0.99079605
82TP53_22573176_ChIP-Seq_HFKS_Human0.98829398
83RUNX_20019798_ChIP-Seq_JUKART_Human0.98552788
84TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98218443
85P300_19829295_ChIP-Seq_ESCs_Human0.97840214
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97719271
87EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97478289
88NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97391791
89GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.94382818
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94123155
91RAC3_21632823_ChIP-Seq_H3396_Human0.93634850
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93393823
93IGF1R_20145208_ChIP-Seq_DFB_Human0.92696196
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91494776
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91192305
96TCF4_22108803_ChIP-Seq_LS180_Human0.90006098
97TP63_23658742_ChIP-Seq_EP156T_Human0.89545088
98CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88974739
99FOXM1_23109430_ChIP-Seq_U2OS_Human0.88803033
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88481692

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow6.93725379
2MP0009780_abnormal_chondrocyte_physiolo6.83348546
3MP0002876_abnormal_thyroid_physiology5.59070045
4MP0005503_abnormal_tendon_morphology4.10722499
5MP0005360_urolithiasis4.09063406
6MP0001968_abnormal_touch/_nociception3.77718506
7MP0000678_abnormal_parathyroid_gland3.64755558
8MP0003941_abnormal_skin_development3.53784072
9MP0000681_abnormal_thyroid_gland2.59853807
10MP0005397_hematopoietic_system_phenotyp2.58807238
11MP0001545_abnormal_hematopoietic_system2.58807238
12MP0010234_abnormal_vibrissa_follicle2.55992008
13MP0009764_decreased_sensitivity_to2.48841536
14MP0003880_abnormal_central_pattern2.48507291
15MP0003183_abnormal_peptide_metabolism2.43565476
16MP0008057_abnormal_DNA_replication2.41572933
17MP0003045_fibrosis2.33083632
18MP0001501_abnormal_sleep_pattern2.31638201
19MP0005646_abnormal_pituitary_gland2.31550205
20MP0003191_abnormal_cellular_cholesterol2.19071038
21MP0006035_abnormal_mitochondrial_morpho2.17912284
22MP0001664_abnormal_digestion2.16318839
23MP0009333_abnormal_splenocyte_physiolog2.13184739
24MP0005551_abnormal_eye_electrophysiolog1.94536387
25MP0002796_impaired_skin_barrier1.89568721
26MP0002249_abnormal_larynx_morphology1.88033765
27MP0000015_abnormal_ear_pigmentation1.73943804
28MP0005645_abnormal_hypothalamus_physiol1.61268384
29MP0003950_abnormal_plasma_membrane1.61169762
30MP0003633_abnormal_nervous_system1.60825417
31MP0003879_abnormal_hair_cell1.58359289
32MP0004858_abnormal_nervous_system1.54319949
33MP0003638_abnormal_response/metabolism_1.49099566
34MP0003959_abnormal_lean_body1.41391816
35MP0002733_abnormal_thermal_nociception1.37023674
36MP0003195_calcinosis1.34318782
37MP0001881_abnormal_mammary_gland1.32793755
38MP0004782_abnormal_surfactant_physiolog1.31688688
39MP0003646_muscle_fatigue1.27687295
40MP0002971_abnormal_brown_adipose1.20546846
41MP0009046_muscle_twitch1.19749915
42MP0003567_abnormal_fetal_cardiomyocyte1.14415523
43MP0009745_abnormal_behavioral_response1.09358885
44MP0005501_abnormal_skin_physiology1.06415435
45MP0000372_irregular_coat_pigmentation0.97478478
46MP0002168_other_aberrant_phenotype0.94723765
47MP0002272_abnormal_nervous_system0.93453956
48MP0000749_muscle_degeneration0.93133260
49MP0009765_abnormal_xenobiotic_induced0.92753829
50MP0001270_distended_abdomen0.90808568
51MP0001324_abnormal_eye_pigmentation0.87351104
52MP0010771_integument_phenotype0.86495570
53MP0000230_abnormal_systemic_arterial0.86297564
54MP0003631_nervous_system_phenotype0.82486579
55MP0002108_abnormal_muscle_morphology0.79130009
56MP0008775_abnormal_heart_ventricle0.78236804
57MP0003937_abnormal_limbs/digits/tail_de0.77029504
58MP0002693_abnormal_pancreas_physiology0.76619776
59MP0002148_abnormal_hypersensitivity_rea0.76222718
60MP0005334_abnormal_fat_pad0.75769185
61MP0009384_cardiac_valve_regurgitation0.75172398
62MP0008874_decreased_physiological_sensi0.74579374
63MP0004264_abnormal_extraembryonic_tissu0.74067489
64MP0005670_abnormal_white_adipose0.73893850
65MP0005167_abnormal_blood-brain_barrier0.73673718
66MP0001970_abnormal_pain_threshold0.73572514
67MP0000358_abnormal_cell_content/0.73035784
68MP0005310_abnormal_salivary_gland0.70531174
69MP0004147_increased_porphyrin_level0.70177809
70MP0000569_abnormal_digit_pigmentation0.67010150
71MP0001486_abnormal_startle_reflex0.66114028
72MP0005195_abnormal_posterior_eye0.64190474
73MP0003868_abnormal_feces_composition0.63521410
74MP0009672_abnormal_birth_weight0.62516751
75MP0002229_neurodegeneration0.61905741
76MP0000049_abnormal_middle_ear0.60032591
77MP0001919_abnormal_reproductive_system0.57397625
78MP0003806_abnormal_nucleotide_metabolis0.54324237
79MP0004130_abnormal_muscle_cell0.51278465
80MP0004859_abnormal_synaptic_plasticity0.50308043
81MP0002095_abnormal_skin_pigmentation0.49963436
82MP0003936_abnormal_reproductive_system0.48446793
83MP0000627_abnormal_mammary_gland0.47766714
84MP0005452_abnormal_adipose_tissue0.47749671
85MP0003136_yellow_coat_color0.46981704
86MP0008872_abnormal_physiological_respon0.44892551
87MP0002557_abnormal_social/conspecific_i0.44142678
88MP0010678_abnormal_skin_adnexa0.43656490
89MP0002069_abnormal_eating/drinking_beha0.42452558
90MP0009643_abnormal_urine_homeostasis0.41252128
91MP0001485_abnormal_pinna_reflex0.40851086
92MP0001963_abnormal_hearing_physiology0.40612621
93MP0005395_other_phenotype0.39912165
94MP0000432_abnormal_head_morphology0.38867491
95MP0004085_abnormal_heartbeat0.38526733
96MP0001756_abnormal_urination0.38126058
97MP0006054_spinal_hemorrhage0.35931406
98MP0002067_abnormal_sensory_capabilities0.32991342
99MP0005390_skeleton_phenotype0.32303305
100MP0003953_abnormal_hormone_level0.31749416

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)7.85151956
2Intestinal atresia (HP:0011100)7.54559126
3Abnormality of the aortic arch (HP:0012303)6.56402113
4Pancreatic islet-cell hyperplasia (HP:0004510)6.49571887
5Broad alveolar ridges (HP:0000187)6.10296888
6Thickened helices (HP:0000391)5.65635340
7Large for gestational age (HP:0001520)5.40244449
8Poor head control (HP:0002421)5.18355692
9Oligodontia (HP:0000677)5.11848625
10Congenital ichthyosiform erythroderma (HP:0007431)4.56565496
11Agitation (HP:0000713)4.56396772
12Focal motor seizures (HP:0011153)4.43001839
13Mesangial abnormality (HP:0001966)4.36186046
14Abnormality of endocrine pancreas physiology (HP:0012093)4.29860455
15Abnormality of the pancreatic islet cells (HP:0006476)4.29860455
16Gaze-evoked nystagmus (HP:0000640)4.23690551
17Abnormality of the ileum (HP:0001549)4.04391810
18Chromosomal breakage induced by crosslinking agents (HP:0003221)4.02925338
19Large eyes (HP:0001090)3.70923185
20Gastrointestinal atresia (HP:0002589)3.68786532
21Tented upper lip vermilion (HP:0010804)3.52316646
22Tubular atrophy (HP:0000092)3.51555331
23Chromsome breakage (HP:0040012)3.49031072
24Myositis (HP:0100614)3.12546805
25Abnormality of the alveolar ridges (HP:0006477)3.10843959
26Nephroblastoma (Wilms tumor) (HP:0002667)3.10415514
27Hyperpituitarism (HP:0010514)3.00966887
28Hypoproteinemia (HP:0003075)2.96416327
29Embryonal renal neoplasm (HP:0011794)2.92661749
30Hyperthyroidism (HP:0000836)2.84397831
31Cerebellar dysplasia (HP:0007033)2.81885407
32Orchitis (HP:0100796)2.77325012
33Type II lissencephaly (HP:0007260)2.75731149
34Pili torti (HP:0003777)2.73427130
35Poor speech (HP:0002465)2.58006494
36Ectropion (HP:0000656)2.56572913
37Neonatal respiratory distress (HP:0002643)2.55141726
38Broad-based gait (HP:0002136)2.46066951
39Abnormality of nail color (HP:0100643)2.45828413
40Optic nerve hypoplasia (HP:0000609)2.44941683
41Abnormality of macular pigmentation (HP:0008002)2.37558743
42Nonprogressive disorder (HP:0003680)2.35790538
43Restlessness (HP:0000711)2.33317974
44Aplasia/Hypoplasia of the brainstem (HP:0007362)2.31975081
45Hypoplasia of the brainstem (HP:0002365)2.31975081
46Long nose (HP:0003189)2.31138920
47Goiter (HP:0000853)2.30423360
48Focal seizures (HP:0007359)2.30243336
49Dialeptic seizures (HP:0011146)2.28690714
50Abnormal hair laboratory examination (HP:0003328)2.25116371
51Testicular neoplasm (HP:0010788)2.24200249
52Striae distensae (HP:0001065)2.23983000
53Dysdiadochokinesis (HP:0002075)2.23265647
54High anterior hairline (HP:0009890)2.23159571
55Lissencephaly (HP:0001339)2.22959368
56Abnormality of the vitreous humor (HP:0004327)2.22327264
57Increased corneal curvature (HP:0100692)2.19677260
58Keratoconus (HP:0000563)2.19677260
59Progressive inability to walk (HP:0002505)2.19294334
60Cutaneous melanoma (HP:0012056)2.18169561
61Central scotoma (HP:0000603)2.17073890
62Impulsivity (HP:0100710)2.16276316
63Amelogenesis imperfecta (HP:0000705)2.16235532
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10916736
65Entropion (HP:0000621)2.10196427
66Elevated erythrocyte sedimentation rate (HP:0003565)2.08217610
67Generalized tonic-clonic seizures (HP:0002069)2.05924245
68Hypercortisolism (HP:0001578)2.05813683
69Pigmentary retinal degeneration (HP:0001146)2.02272386
70Thyroid-stimulating hormone excess (HP:0002925)14.7203314
71Hamartoma (HP:0010566)1.99291147
72Lack of skin elasticity (HP:0100679)1.98006075
73Congenital stationary night blindness (HP:0007642)1.97934657
74Hypohidrosis (HP:0000966)1.96363788
75Hydroxyprolinuria (HP:0003080)1.95087624
76Abnormality of proline metabolism (HP:0010907)1.95087624
77Hypoplasia of the pons (HP:0012110)1.93918842
78Poikiloderma (HP:0001029)1.91877561
79Scotoma (HP:0000575)1.88303842
80Peritonitis (HP:0002586)1.88252977
81Pendular nystagmus (HP:0012043)1.85948926
82Ileus (HP:0002595)1.85005010
83Abnormality of the columella (HP:0009929)1.84428545
84Abnormality of liposaccharide metabolism (HP:0010968)1.82928841
85Abnormality of glycosphingolipid metabolism (HP:0004343)1.82928841
86Abnormality of glycolipid metabolism (HP:0010969)1.82928841
87Muscular dystrophy (HP:0003560)1.82171277
88Attenuation of retinal blood vessels (HP:0007843)1.79670633
89Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.77548094
90Abnormality of the pons (HP:0007361)1.75698988
91Non-midline cleft lip (HP:0100335)1.75563208
92Episodic fever (HP:0001954)1.74569718
93Severe visual impairment (HP:0001141)1.71698814
94Duplicated collecting system (HP:0000081)1.70845513
95Autoimmune hemolytic anemia (HP:0001890)1.70508338
96Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68964875
97Neoplasm of the lung (HP:0100526)1.68869860
98Choroideremia (HP:0001139)1.66195493
99Embryonal neoplasm (HP:0002898)1.65897916
1003-Methylglutaconic aciduria (HP:0003535)1.65856131

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.55310649
2FRK5.49692724
3PINK13.80061922
4IRAK33.30205993
5ADRBK12.91597617
6PNCK2.17940976
7ADRBK211.3104450
8TYRO31.98316818
9DYRK31.96492426
10IRAK11.87454266
11ACVR1B1.86845806
12PRKCG1.86541268
13TGFBR11.72090749
14RIPK11.59573910
15PRKCE1.59310400
16MAPK111.43408530
17CLK11.41814460
18WEE11.16752601
19BMPR1B1.13064326
20PLK21.07558792
21NEK91.03214669
22PRKCI1.02385711
23GRK10.99841142
24CAMK1G0.87085884
25ERBB20.80340172
26STK30.79184997
27CAMK2A0.78924445
28MAPKAPK30.71586376
29STK38L0.68856693
30BRSK10.68707276
31MAPKAPK50.68108365
32NEK20.67448153
33MARK30.62809303
34PTK2B0.61278401
35TEC0.59468421
36PKN20.59020990
37GRK50.55856816
38GRK70.53568369
39STK380.53333014
40MKNK10.50072430
41BRAF0.47621632
42MELK0.43735649
43PRKCH0.41583727
44CAMK10.41379885
45STK100.41159310
46DYRK1A0.39373864
47SGK10.39059182
48PRKCB0.37940461
49FLT30.33991689
50MAPK10.32747415
51CSNK1E0.30240789
52PRKCA0.29949626
53TAOK30.28631140
54CSNK1A1L0.28440989
55MOS0.28313609
56EEF2K0.27361645
57MAP2K20.27163147
58ITK0.27059014
59AKT10.26886096
60MAPK30.26212937
61EIF2AK30.25771771
62OXSR10.23918611
63CAMK40.23754777
64CSNK2A20.22959943
65TGFBR20.22781062
66MST40.22551585
67ABL10.22507302
68CDC42BPA0.22489183
69RPS6KA30.22383683
70FER0.20211317
71PAK60.20138042
72MATK0.20033693
73STK390.18489752
74CSNK1A10.18322761
75MAP3K80.17569805
76MAP2K10.17188243
77AURKB0.15817850
78CSNK1G30.14872750
79PRKACG0.14329842
80GSK3B0.13841261
81ATR0.13348010
82TAOK10.12995813
83PIK3CG0.12207287
84PRKACA0.12022647
85STK240.11637729
86SIK20.11467028
87ATM0.10736347
88CSNK1G10.10385604
89PRKAA10.10080935
90NME20.09707936
91PDK10.08954367
92TNK20.08397850
93MAPK100.08230278
94FGFR20.07388258
95MKNK20.07337681
96IGF1R0.06863053
97TXK0.06705274
98CSNK2A10.06535166
99CDK10.06414240
100NTRK20.04871069

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.59308906
2Dorso-ventral axis formation_Homo sapiens_hsa043204.51358241
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.56057556
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.34537238
5Olfactory transduction_Homo sapiens_hsa047403.30407335
6Steroid hormone biosynthesis_Homo sapiens_hsa001403.25389849
7Sphingolipid metabolism_Homo sapiens_hsa006003.12185220
8ABC transporters_Homo sapiens_hsa020102.94026576
9Pentose phosphate pathway_Homo sapiens_hsa000302.60482943
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.51272207
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.44428764
12Phototransduction_Homo sapiens_hsa047442.38821183
13Morphine addiction_Homo sapiens_hsa050322.35667344
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.26778681
15Fanconi anemia pathway_Homo sapiens_hsa034602.11018893
16Glycerolipid metabolism_Homo sapiens_hsa005611.96882667
17Ovarian steroidogenesis_Homo sapiens_hsa049131.91428942
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.62865230
19Butanoate metabolism_Homo sapiens_hsa006501.56597918
20Sulfur relay system_Homo sapiens_hsa041221.56374916
21Arachidonic acid metabolism_Homo sapiens_hsa005901.52622644
22Linoleic acid metabolism_Homo sapiens_hsa005911.49744327
23Starch and sucrose metabolism_Homo sapiens_hsa005001.47886975
24Taste transduction_Homo sapiens_hsa047421.46555639
25Complement and coagulation cascades_Homo sapiens_hsa046101.43922749
26Tryptophan metabolism_Homo sapiens_hsa003801.39511516
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37850375
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30927047
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29662859
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21404703
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20856348
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20650636
33Caffeine metabolism_Homo sapiens_hsa002321.18682118
34Estrogen signaling pathway_Homo sapiens_hsa049151.12576065
35Mineral absorption_Homo sapiens_hsa049781.06467376
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06307171
37Retinol metabolism_Homo sapiens_hsa008301.03139050
38Fatty acid degradation_Homo sapiens_hsa000710.98440323
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92985420
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91225699
41Chemical carcinogenesis_Homo sapiens_hsa052040.90640072
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84514642
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83955366
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82331051
45Glutathione metabolism_Homo sapiens_hsa004800.78059995
46Basal transcription factors_Homo sapiens_hsa030220.76832587
47Calcium signaling pathway_Homo sapiens_hsa040200.73170152
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.73108723
49Nitrogen metabolism_Homo sapiens_hsa009100.73073331
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70515209
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.70234543
52MicroRNAs in cancer_Homo sapiens_hsa052060.69839294
53Salivary secretion_Homo sapiens_hsa049700.69142654
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68953698
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68559067
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66312481
57Histidine metabolism_Homo sapiens_hsa003400.63743861
58ECM-receptor interaction_Homo sapiens_hsa045120.63364023
59Ether lipid metabolism_Homo sapiens_hsa005650.62907331
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.58418440
61mRNA surveillance pathway_Homo sapiens_hsa030150.57261258
62Pancreatic secretion_Homo sapiens_hsa049720.56599565
63Arginine biosynthesis_Homo sapiens_hsa002200.55737605
64Legionellosis_Homo sapiens_hsa051340.54278809
65Metabolic pathways_Homo sapiens_hsa011000.53918803
66Lysosome_Homo sapiens_hsa041420.51896536
67Homologous recombination_Homo sapiens_hsa034400.51234690
68Peroxisome_Homo sapiens_hsa041460.46225799
69Circadian entrainment_Homo sapiens_hsa047130.44238092
70Glutamatergic synapse_Homo sapiens_hsa047240.43027734
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.42759483
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42744561
73One carbon pool by folate_Homo sapiens_hsa006700.38653652
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38520652
75Fatty acid biosynthesis_Homo sapiens_hsa000610.37643307
76Serotonergic synapse_Homo sapiens_hsa047260.34763350
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33804953
78Basal cell carcinoma_Homo sapiens_hsa052170.32571011
79Arginine and proline metabolism_Homo sapiens_hsa003300.32446073
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.30702399
81Purine metabolism_Homo sapiens_hsa002300.28720687
82Notch signaling pathway_Homo sapiens_hsa043300.27171222
83RNA degradation_Homo sapiens_hsa030180.26993966
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.25540888
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24847452
86Hedgehog signaling pathway_Homo sapiens_hsa043400.23219986
87Base excision repair_Homo sapiens_hsa034100.23065559
88Glucagon signaling pathway_Homo sapiens_hsa049220.20893070
89beta-Alanine metabolism_Homo sapiens_hsa004100.20160236
90Protein digestion and absorption_Homo sapiens_hsa049740.17843624
91Graft-versus-host disease_Homo sapiens_hsa053320.16947387
92Insulin secretion_Homo sapiens_hsa049110.16859870
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.15135825
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.14541323
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14385668
96Oxytocin signaling pathway_Homo sapiens_hsa049210.13555908
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.13112663
98T cell receptor signaling pathway_Homo sapiens_hsa046600.12288323
99PPAR signaling pathway_Homo sapiens_hsa033200.11469998
100ErbB signaling pathway_Homo sapiens_hsa040120.10909620

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