ARSI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to a large family of sulfatases that hydrolyze sulfate esters and sulfamates. Members of this family play a role in several cellular processes, including hormone synthesis, cell signaling in development and degradation of macromolecules. The protein encoded by this gene is thought to be secreted, and to function in extracellular space. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bone trabecula formation (GO:0060346)7.03655420
2daunorubicin metabolic process (GO:0044597)6.50804358
3polyketide metabolic process (GO:0030638)6.50804358
4doxorubicin metabolic process (GO:0044598)6.50804358
5desmosome organization (GO:0002934)6.22005053
6cell-substrate junction assembly (GO:0007044)5.83761854
7protein heterotrimerization (GO:0070208)5.79079218
8cell adhesion mediated by integrin (GO:0033627)5.52536924
9collagen fibril organization (GO:0030199)5.09926433
10regulation of response to osmotic stress (GO:0047484)4.76333987
11notochord development (GO:0030903)4.64319573
12negative regulation of epidermis development (GO:0045683)4.39362746
13cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.36654411
14bundle of His cell to Purkinje myocyte communication (GO:0086069)4.25574170
15negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.06154370
16keratan sulfate catabolic process (GO:0042340)4.02736370
17aminoglycoside antibiotic metabolic process (GO:0030647)4.01179718
18maintenance of protein location in nucleus (GO:0051457)3.91947694
19regulation of mammary gland epithelial cell proliferation (GO:0033599)3.85493097
20somite rostral/caudal axis specification (GO:0032525)3.85172979
21negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.79478573
22dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.78678656
23basement membrane organization (GO:0071711)3.75525760
24protein localization to kinetochore (GO:0034501)3.72921702
25negative regulation of chondrocyte differentiation (GO:0032331)3.72006337
26collagen metabolic process (GO:0032963)3.68681459
27mesodermal cell differentiation (GO:0048333)3.68482101
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.68393182
29regulation of apoptotic process involved in morphogenesis (GO:1902337)3.68224260
30regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.68049588
31collagen catabolic process (GO:0030574)3.66054699
32COPI coating of Golgi vesicle (GO:0048205)3.65210305
33Golgi transport vesicle coating (GO:0048200)3.65210305
34cell-substrate adherens junction assembly (GO:0007045)3.64606951
35focal adhesion assembly (GO:0048041)3.64606951
36muscle organ morphogenesis (GO:0048644)3.64316229
37protein retention in ER lumen (GO:0006621)3.63392596
38cell proliferation involved in metanephros development (GO:0072203)3.62210409
39protein localization to endosome (GO:0036010)3.61063885
40negative regulation of keratinocyte proliferation (GO:0010839)3.58644375
41negative regulation of cell cycle G2/M phase transition (GO:1902750)3.54735210
42gap junction assembly (GO:0016264)3.54662132
43hormone catabolic process (GO:0042447)3.50709143
44adherens junction assembly (GO:0034333)3.49827275
45tachykinin receptor signaling pathway (GO:0007217)3.49607020
46extracellular fibril organization (GO:0043206)3.48983896
47regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.46628139
48regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.45605537
49multicellular organismal macromolecule metabolic process (GO:0044259)3.45390340
50skin morphogenesis (GO:0043589)3.44090178
51regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.41809017
52heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.41785598
53extracellular matrix assembly (GO:0085029)3.40923493
54cellular response to vitamin D (GO:0071305)3.39071948
55regulation of transforming growth factor beta2 production (GO:0032909)3.37592902
56negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.32851888
57multicellular organismal catabolic process (GO:0044243)3.32696790
58cell aggregation (GO:0098743)3.27065376
59cartilage condensation (GO:0001502)3.27065376
60planar cell polarity pathway involved in neural tube closure (GO:0090179)3.26488211
61G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.26439651
62cellular response to vitamin (GO:0071295)3.25705004
63positive regulation of odontogenesis (GO:0042482)3.25459874
64endodermal cell differentiation (GO:0035987)3.24879511
65regulation of telomere maintenance via telomerase (GO:0032210)3.23577429
66multicellular organismal metabolic process (GO:0044236)3.23234178
67positive regulation of histone deacetylation (GO:0031065)3.21589283
68chondrocyte development (GO:0002063)3.19158506
69endothelial cell morphogenesis (GO:0001886)3.15060613
70establishment of tissue polarity (GO:0007164)3.14769698
71establishment of planar polarity (GO:0001736)3.14769698
72keratinocyte proliferation (GO:0043616)3.14364723
73heterochromatin organization (GO:0070828)3.13645624
74extracellular matrix disassembly (GO:0022617)3.12601273
75branching involved in mammary gland duct morphogenesis (GO:0060444)3.11517323
76endochondral ossification (GO:0001958)3.10649763
77replacement ossification (GO:0036075)3.10649763
78vitamin A metabolic process (GO:0006776)3.08556744
79negative regulation of fibrinolysis (GO:0051918)3.07505954
80regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.07045156
81sequestering of extracellular ligand from receptor (GO:0035581)3.06722701
82phenol-containing compound catabolic process (GO:0019336)3.06360513
83positive regulation of DNA-dependent DNA replication (GO:2000105)3.06033687
84negative regulation of telomerase activity (GO:0051974)3.03853663
85positive regulation of smoothened signaling pathway (GO:0045880)3.01721740
86bone morphogenesis (GO:0060349)3.01710252
87histone H4-K8 acetylation (GO:0043982)2.99434627
88histone H4-K5 acetylation (GO:0043981)2.99434627
89fibril organization (GO:0097435)2.98036335
90cell proliferation involved in kidney development (GO:0072111)2.96715088
91polarized epithelial cell differentiation (GO:0030859)2.94126565
92peptidyl-glutamic acid carboxylation (GO:0017187)2.93916552
93protein carboxylation (GO:0018214)2.93916552
94protein hydroxylation (GO:0018126)2.92745556
95regulation of plasminogen activation (GO:0010755)2.91592430
96chondrocyte proliferation (GO:0035988)2.91325677
97epithelial cell-cell adhesion (GO:0090136)2.90554808
98cellular response to osmotic stress (GO:0071470)2.90302309
99axon extension involved in axon guidance (GO:0048846)2.90058894
100neuron projection extension involved in neuron projection guidance (GO:1902284)2.90058894
101hypotonic response (GO:0006971)2.89513908
102regulation of early endosome to late endosome transport (GO:2000641)2.89072244
103heparan sulfate proteoglycan metabolic process (GO:0030201)2.87784830
104primitive streak formation (GO:0090009)2.87665400
105cytoskeletal anchoring at plasma membrane (GO:0007016)2.87237265
106positive regulation of protein deacetylation (GO:0090312)2.84400482
107interferon-gamma production (GO:0032609)2.84341023
108positive regulation of endothelial cell apoptotic process (GO:2000353)2.84053265
109cochlea morphogenesis (GO:0090103)2.83885942
110cell junction assembly (GO:0034329)2.83058583
111regulation of odontogenesis (GO:0042481)2.82871046
112rRNA transcription (GO:0009303)2.79658375
113anatomical structure regression (GO:0060033)2.79118653
114maintenance of protein localization in organelle (GO:0072595)2.78071569
115substrate-dependent cell migration (GO:0006929)2.77139884
116negative regulation of cartilage development (GO:0061037)2.75399154
117convergent extension (GO:0060026)2.74413526
118negative regulation of epidermal cell differentiation (GO:0045605)2.74108393
119embryonic skeletal joint morphogenesis (GO:0060272)2.73238967
120cardiac muscle cell proliferation (GO:0060038)2.73167669
121wound healing, spreading of epidermal cells (GO:0035313)2.73076111
122maternal placenta development (GO:0001893)2.72095951
123cell junction organization (GO:0034330)2.72049129
124apoptotic cell clearance (GO:0043277)2.69559344
125regulation of hair follicle development (GO:0051797)2.68726436
126mitotic sister chromatid segregation (GO:0000070)2.68086860
127pinocytosis (GO:0006907)2.67940847
128histone H4-K12 acetylation (GO:0043983)2.67518094
129extracellular matrix organization (GO:0030198)2.66699245
130cytidine deamination (GO:0009972)2.66603785
131cytidine metabolic process (GO:0046087)2.66603785
132cytidine catabolic process (GO:0006216)2.66603785
133glomerular basement membrane development (GO:0032836)2.66146777
134extracellular structure organization (GO:0043062)2.65540714
135Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.64190572
136positive regulation of epithelial to mesenchymal transition (GO:0010718)2.64147556
137paraxial mesoderm development (GO:0048339)2.63524523
138protein maturation by protein folding (GO:0022417)2.61874100
139genitalia morphogenesis (GO:0035112)2.61571265
140cell migration involved in heart development (GO:0060973)2.61563161
141cell fate commitment involved in formation of primary germ layer (GO:0060795)2.61132372
142stress fiber assembly (GO:0043149)2.60712927
143regulation of metalloenzyme activity (GO:0048552)2.60591502
144establishment of endothelial barrier (GO:0061028)2.60181892
145head development (GO:0060322)2.59652956
146regulation of nuclear cell cycle DNA replication (GO:0033262)2.59115635
147chromatin assembly (GO:0031497)2.58506953
148peptidyl-proline hydroxylation (GO:0019511)2.57960022
149negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.57506680
150mammary gland development (GO:0030879)2.57119143
151regulation of extracellular matrix disassembly (GO:0010715)2.57112442
152phagocytosis, recognition (GO:0006910)2.56705398
153skeletal system development (GO:0001501)2.56579965
154L-serine transport (GO:0015825)2.56546033
155wound healing, spreading of cells (GO:0044319)2.55519258
156non-canonical Wnt signaling pathway (GO:0035567)2.55175456
157regulation of establishment of planar polarity (GO:0090175)2.55064262
158positive regulation of extracellular matrix organization (GO:1903055)2.54971766
159wound healing (GO:0042060)2.51731400
160positive regulation of osteoblast proliferation (GO:0033690)2.51476585
161atrioventricular valve morphogenesis (GO:0003181)2.51013698
162negative regulation of fatty acid transport (GO:2000192)2.49895977
163cellular copper ion homeostasis (GO:0006878)2.48654093
164craniofacial suture morphogenesis (GO:0097094)2.48631817
165positive regulation of blood vessel endothelial cell migration (GO:0043536)2.48466528
166adherens junction organization (GO:0034332)2.45503630
167type B pancreatic cell proliferation (GO:0044342)2.45392740
168branching involved in salivary gland morphogenesis (GO:0060445)2.45010970
169actin filament depolymerization (GO:0030042)2.44142327
1704-hydroxyproline metabolic process (GO:0019471)2.43252355
171hemidesmosome assembly (GO:0031581)10.2018960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.00544301
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.00544301
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.00544301
4TRIM28_21343339_ChIP-Seq_HEK293_Human4.71805188
5TP63_17297297_ChIP-ChIP_HaCaT_Human4.50113905
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.40409779
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.32660926
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.21347862
9E2F7_22180533_ChIP-Seq_HELA_Human3.01024586
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.72889939
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.56798287
12ZNF263_19887448_ChIP-Seq_K562_Human2.56518536
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.54808246
14SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.28177216
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.26097714
16WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.21253308
17SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.21031919
18SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.21031919
19TCF3_18692474_ChIP-Seq_MEFs_Mouse2.20376812
20WT1_19549856_ChIP-ChIP_CCG9911_Human2.14669791
21RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.12530919
22ZFP281_18757296_ChIP-ChIP_E14_Mouse2.09421800
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07601767
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.06632171
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.95824776
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.95273249
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.93213417
28* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.92705111
29ZFP281_27345836_Chip-Seq_ESCs_Mouse1.90502562
30UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.88748363
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.88184500
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.87823972
33TCF3_18692474_ChIP-Seq_MESCs_Mouse1.87670424
34SOX9_24532713_ChIP-Seq_HFSC_Mouse1.87095446
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83574435
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.80335398
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79805231
38UBF1/2_26484160_Chip-Seq_HMECs_Human1.77939783
39TP53_20018659_ChIP-ChIP_R1E_Mouse1.76156687
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76067902
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.72659614
42* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69206918
43ATF3_27146783_Chip-Seq_COLON_Human1.65820879
44KDM2B_26808549_Chip-Seq_K562_Human1.65384347
45NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.61861585
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.60887522
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60269143
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57270506
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52264433
50AR_21909140_ChIP-Seq_LNCAP_Human1.51406720
51* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51207603
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.50708783
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.50529962
54MYC_22102868_ChIP-Seq_BL_Human1.49031572
55* CJUN_26792858_Chip-Seq_BT549_Human1.47581843
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46982268
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.45911902
58TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.45594578
59SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.44393934
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41173333
61CDX2_20551321_ChIP-Seq_CACO-2_Human1.39555287
62TCF7_22412390_ChIP-Seq_EML_Mouse1.38702798
63ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.38189549
64NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34911530
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.34765670
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34424989
67TP53_22127205_ChIP-Seq_IMR90_Human1.33768736
68* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33570374
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32196418
70RACK7_27058665_Chip-Seq_MCF-7_Human1.31703576
71* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31003520
72* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31003520
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30872949
74POU5F1_16518401_ChIP-PET_MESCs_Mouse1.30732039
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29176867
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27166979
77KDM2B_26808549_Chip-Seq_DND41_Human1.25537386
78TBX3_20139965_ChIP-Seq_ESCs_Mouse1.23771737
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23598392
80PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.22988113
81TBX3_20139965_ChIP-Seq_MESCs_Mouse1.22509506
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20308184
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19673106
84RXR_22158963_ChIP-Seq_LIVER_Mouse1.18969483
85ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17822132
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17491713
87LXR_22292898_ChIP-Seq_THP-1_Human1.17167909
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16960010
89NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15696900
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.15436455
91* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13694524
92EP300_21415370_ChIP-Seq_HL-1_Mouse1.12336972
93TBX20_22328084_ChIP-Seq_HEART_Mouse1.11564886
94TBX20_22080862_ChIP-Seq_HEART_Mouse1.11564886
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09857698
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09317925
97* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07288304
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07245106
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07013985
100TP53_18474530_ChIP-ChIP_U2OS_Human1.06356404
101CLOCK_20551151_ChIP-Seq_293T_Human1.05662169
102SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05389898
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04257740
104FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04048296
105SOX2_20726797_ChIP-Seq_SW620_Human1.03773532
106NANOG_16153702_ChIP-ChIP_HESCs_Human1.02192194
107NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01657171
108* TP63_22573176_ChIP-Seq_HFKS_Human1.00699958
109* BRD4_25478319_ChIP-Seq_HGPS_Human1.00448141
110NANOG_18692474_ChIP-Seq_MEFs_Mouse1.00119431
111* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98993828
112* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98573061
113FOXA2_19822575_ChIP-Seq_HepG2_Human0.98034261
114SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97412813
115PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97012112
116TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.97000680
117SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96447522
118RNF2_27304074_Chip-Seq_ESCs_Mouse0.96425392
119NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96150734
120KDM2B_26808549_Chip-Seq_JURKAT_Human0.96125955
121EED_16625203_ChIP-ChIP_MESCs_Mouse0.95863568
122* TET1_21490601_ChIP-Seq_MESCs_Mouse0.95837362
123ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95714162
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95535150
125NCOR1_26117541_ChIP-Seq_K562_Human0.95317859
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94801499
127KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94665979
128KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93239488
129* RING1B_27294783_Chip-Seq_ESCs_Mouse0.91604648
130TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90633231
131SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90331543
132SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90326439
133GATA2_21666600_ChIP-Seq_HMVEC_Human0.90290649
134NANOG_18692474_ChIP-Seq_MESCs_Mouse0.90240103
135RUNX1_27514584_Chip-Seq_MCF-7_Human0.90208217
136NANOG_16518401_ChIP-PET_MESCs_Mouse0.89897519
137STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89432037
138CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86276039
139SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86151736
140CTCF_21964334_Chip-Seq_Bcells_Human0.86022512
141NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85550352
142POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85523086
143THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84260263
144TP53_23651856_ChIP-Seq_MEFs_Mouse0.84186555
145CSB_26484114_Chip-Seq_FIBROBLAST_Human0.83725200
146* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83077223
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82478082
148EZH2_27304074_Chip-Seq_ESCs_Mouse0.82436559
149SMC4_20622854_ChIP-Seq_HELA_Human0.82278916
150GATA3_24758297_ChIP-Seq_MCF-7_Human0.81860028
151KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81831559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.20738232
2MP0005503_abnormal_tendon_morphology4.72810051
3MP0005275_abnormal_skin_tensile4.50534827
4MP0003705_abnormal_hypodermis_morpholog4.17752579
5MP0000579_abnormal_nail_morphology4.03493567
6MP0005257_abnormal_intraocular_pressure2.98226547
7MP0003279_aneurysm2.83220644
8MP0002254_reproductive_system_inflammat2.74087413
9MP0005508_abnormal_skeleton_morphology2.45090712
10MP0004272_abnormal_basement_membrane2.44957906
11MP0003950_abnormal_plasma_membrane2.44485403
12MP0003011_delayed_dark_adaptation2.41348985
13MP0001958_emphysema2.36641233
14MP0010030_abnormal_orbit_morphology2.31250063
15MP0004858_abnormal_nervous_system2.13648159
16MP0009250_abnormal_appendicular_skeleto2.12333700
17MP0003122_maternal_imprinting2.01170075
18MP0010352_gastrointestinal_tract_polyps1.97366516
19MP0005409_darkened_coat_color1.96864530
20MP0001849_ear_inflammation1.90212525
21MP0000467_abnormal_esophagus_morphology1.84469626
22MP0005623_abnormal_meninges_morphology1.83537492
23MP0006054_spinal_hemorrhage1.83217221
24MP0002108_abnormal_muscle_morphology1.82037139
25MP0003453_abnormal_keratinocyte_physiol1.81003194
26MP0009053_abnormal_anal_canal1.77297810
27MP0000762_abnormal_tongue_morphology1.75600859
28MP0000049_abnormal_middle_ear1.72275803
29MP0000566_synostosis1.71044718
30MP0002932_abnormal_joint_morphology1.69684259
31MP0001243_abnormal_dermal_layer1.64915239
32MP0000163_abnormal_cartilage_morphology1.63779846
33MP0009384_cardiac_valve_regurgitation1.62988941
34MP0002089_abnormal_postnatal_growth/wei1.59955057
35MP0002060_abnormal_skin_morphology1.56350831
36MP0004264_abnormal_extraembryonic_tissu1.50378769
37MP0001216_abnormal_epidermal_layer1.49611765
38MP0000428_abnormal_craniofacial_morphol1.48755240
39MP0001299_abnormal_eye_distance/1.43097403
40MP0002233_abnormal_nose_morphology1.39507910
41MP0002697_abnormal_eye_size1.38243307
42MP0003385_abnormal_body_wall1.37001097
43MP0000013_abnormal_adipose_tissue1.36841083
44MP0002092_abnormal_eye_morphology1.36686290
45MP0000432_abnormal_head_morphology1.36451475
46MP0005023_abnormal_wound_healing1.35302556
47MP0001542_abnormal_bone_strength1.33780581
48MP0002249_abnormal_larynx_morphology1.33715248
49MP0008260_abnormal_autophagy1.33111444
50MP0003938_abnormal_ear_development1.33022610
51MP0003755_abnormal_palate_morphology1.32946154
52MP0004134_abnormal_chest_morphology1.32563168
53MP0002877_abnormal_melanocyte_morpholog1.32447822
54MP0005501_abnormal_skin_physiology1.31673322
55MP0005390_skeleton_phenotype1.29104806
56MP0003935_abnormal_craniofacial_develop1.28143415
57MP0000767_abnormal_smooth_muscle1.28104475
58MP0010234_abnormal_vibrissa_follicle1.26716369
59MP0002116_abnormal_craniofacial_bone1.24894245
60MP0003121_genomic_imprinting1.23469532
61MP0003123_paternal_imprinting1.23112773
62MP0005499_abnormal_olfactory_system1.22993443
63MP0005394_taste/olfaction_phenotype1.22993443
64MP0003566_abnormal_cell_adhesion1.22774991
65MP0002933_joint_inflammation1.22335705
66MP0005360_urolithiasis1.22110856
67MP0010771_integument_phenotype1.21619109
68MP0002282_abnormal_trachea_morphology1.19911832
69MP0002114_abnormal_axial_skeleton1.19707782
70MP0009780_abnormal_chondrocyte_physiolo1.17478830
71MP0005197_abnormal_uvea_morphology1.16053843
72MP0002115_abnormal_skeleton_extremities1.15180584
73MP0000003_abnormal_adipose_tissue1.15166479
74MP0000534_abnormal_ureter_morphology1.13244678
75MP0006292_abnormal_olfactory_placode1.11734503
76MP0002113_abnormal_skeleton_development1.11692078
77MP0008961_abnormal_basal_metabolism1.10589931
78MP0001348_abnormal_lacrimal_gland1.10527364
79MP0002109_abnormal_limb_morphology1.10471184
80MP0001915_intracranial_hemorrhage1.10167599
81MP0003283_abnormal_digestive_organ1.07847925
82MP0005058_abnormal_lysosome_morphology1.05944023
83MP0000383_abnormal_hair_follicle1.04434755
84MP0010368_abnormal_lymphatic_system1.02747402
85MP0002896_abnormal_bone_mineralization1.02188199
86MP0002234_abnormal_pharynx_morphology1.02113475
87MP0005193_abnormal_anterior_eye1.01294679
88MP0003942_abnormal_urinary_system0.98480030
89MP0001661_extended_life_span0.97962525
90MP0002332_abnormal_exercise_endurance0.97600086
91MP0003941_abnormal_skin_development0.96069003
92MP0005451_abnormal_body_composition0.95319516
93MP0003937_abnormal_limbs/digits/tail_de0.94999582
94MP0000462_abnormal_digestive_system0.93203276
95MP0002111_abnormal_tail_morphology0.92045790
96MP0003191_abnormal_cellular_cholesterol0.91869759
97MP0003795_abnormal_bone_structure0.90385555
98MP0002295_abnormal_pulmonary_circulatio0.89743869
99MP0003115_abnormal_respiratory_system0.87758274
100MP0000678_abnormal_parathyroid_gland0.87692339
101MP0003890_abnormal_embryonic-extraembry0.87485785
102MP0004197_abnormal_fetal_growth/weight/0.86783894
103MP0002998_abnormal_bone_remodeling0.86229193
104MP0002925_abnormal_cardiovascular_devel0.84901086
105MP0009840_abnormal_foam_cell0.82211889
106MP0002088_abnormal_embryonic_growth/wei0.81362022
107MP0000858_altered_metastatic_potential0.81310028
108MP0003119_abnormal_digestive_system0.80352691
109MP0001672_abnormal_embryogenesis/_devel0.79581076
110MP0005380_embryogenesis_phenotype0.79581076
111MP0004233_abnormal_muscle_weight0.79545984
112MP0003091_abnormal_cell_migration0.77820190
113MP0003984_embryonic_growth_retardation0.77465864
114MP0003448_altered_tumor_morphology0.77350561
115MP0000751_myopathy0.75897572
116MP0001340_abnormal_eyelid_morphology0.75123069
117MP0003315_abnormal_perineum_morphology0.75068894
118MP0001286_abnormal_eye_development0.74999027
119MP0005075_abnormal_melanosome_morpholog0.74053179
120MP0000647_abnormal_sebaceous_gland0.73502355
121MP0001293_anophthalmia0.73182069
122MP0002098_abnormal_vibrissa_morphology0.72634489
123MP0008770_decreased_survivor_rate0.71786709
124MP0005248_abnormal_Harderian_gland0.71384849
125MP0002796_impaired_skin_barrier0.70523350
126MP0000350_abnormal_cell_proliferation0.69668807
127MP0005076_abnormal_cell_differentiation0.68853036
128MP0000750_abnormal_muscle_regeneration0.68823189
129MP0009931_abnormal_skin_appearance0.68666094
130MP0002127_abnormal_cardiovascular_syste0.68215329
131MP0002085_abnormal_embryonic_tissue0.67908945
132MP0002086_abnormal_extraembryonic_tissu0.67571665
133MP0000733_abnormal_muscle_development0.67110221
134MP0010678_abnormal_skin_adnexa0.67029466
135MP0000627_abnormal_mammary_gland0.66867334
136MP0000377_abnormal_hair_follicle0.66822558
137MP0000537_abnormal_urethra_morphology0.66818940
138MP0005621_abnormal_cell_physiology0.66348646
139MP0003329_amyloid_beta_deposits0.66234137
140MP0005408_hypopigmentation0.64767330
141MP0001614_abnormal_blood_vessel0.64402014
142MP0006138_congestive_heart_failure0.62102685

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.78673214
2Premature rupture of membranes (HP:0001788)5.77966929
3Milia (HP:0001056)4.69960442
4Fragile nails (HP:0001808)4.63684983
5Onycholysis (HP:0001806)4.43226483
6Peritonitis (HP:0002586)3.87918566
7Bilateral microphthalmos (HP:0007633)3.84255625
8Arterial tortuosity (HP:0005116)3.58131330
9Mild short stature (HP:0003502)3.55190590
10Plantar hyperkeratosis (HP:0007556)3.52560068
11Neonatal short-limb short stature (HP:0008921)3.48200205
12Ankle contracture (HP:0006466)3.46199063
13Vascular tortuosity (HP:0004948)3.45212942
14Shallow orbits (HP:0000586)3.44102709
15Hepatoblastoma (HP:0002884)3.42655320
16Broad metatarsal (HP:0001783)3.41132340
17Atrophic scars (HP:0001075)3.40346360
18Abnormality of nail color (HP:0100643)3.37210369
19Increased connective tissue (HP:0009025)3.35186899
20Bladder diverticulum (HP:0000015)3.34553955
21Genu recurvatum (HP:0002816)3.34212879
22Vertebral compression fractures (HP:0002953)3.25016354
23Aortic dissection (HP:0002647)3.23985508
24Mitral valve prolapse (HP:0001634)3.11902390
25Alopecia of scalp (HP:0002293)3.06052637
26Mesomelia (HP:0003027)3.04675746
27Soft skin (HP:0000977)2.98855966
28Abnormality of carpal bone ossification (HP:0006257)2.96586191
29Natal tooth (HP:0000695)2.93342395
30Renal duplication (HP:0000075)2.89541152
31Right ventricular cardiomyopathy (HP:0011663)2.89157799
32Nail dystrophy (HP:0008404)2.87483931
33Metaphyseal cupping (HP:0003021)2.86850888
34Pterygium (HP:0001059)2.86479872
35Thick nail (HP:0001805)2.77579633
36Mildly elevated creatine phosphokinase (HP:0008180)2.75875588
37Abnormal ossification of hand bones (HP:0005921)2.73994889
38Follicular hyperkeratosis (HP:0007502)2.71979662
39Osteoarthritis (HP:0002758)2.70792452
40Abnormality of dentin (HP:0010299)2.65194781
41Multiple enchondromatosis (HP:0005701)2.63739170
42Type 1 muscle fiber predominance (HP:0003803)2.62047684
43Fragile skin (HP:0001030)2.61789591
44Mitral stenosis (HP:0001718)2.54904986
45Blue sclerae (HP:0000592)2.54496232
46Rib fusion (HP:0000902)2.51733731
47Selective tooth agenesis (HP:0001592)2.44347338
48Dilatation of the ascending aorta (HP:0005111)2.42294514
49Short nail (HP:0001799)2.40693029
50Epiphyseal dysplasia (HP:0002656)2.40443282
51Abnormality of the lower motor neuron (HP:0002366)2.40024764
52Abnormal cartilage morphology (HP:0002763)2.38478048
53Absent frontal sinuses (HP:0002688)2.37526743
54Cerebral aneurysm (HP:0004944)2.36294181
55Increased variability in muscle fiber diameter (HP:0003557)2.35554489
56Wide anterior fontanel (HP:0000260)2.34662145
57Hypochromic microcytic anemia (HP:0004840)2.33544136
58Flat acetabular roof (HP:0003180)2.31699681
59Bowel diverticulosis (HP:0005222)2.28845244
60Broad palm (HP:0001169)2.25031934
61Wormian bones (HP:0002645)2.24419519
62Abnormality of the distal phalanx of the thumb (HP:0009617)2.24330794
63Abnormal hand bone ossification (HP:0010660)2.23842048
64Aortic aneurysm (HP:0004942)2.23320682
65Small epiphyses (HP:0010585)2.22628268
66Nuclear cataract (HP:0100018)2.21946116
67Advanced eruption of teeth (HP:0006288)2.21062729
68Cervical subluxation (HP:0003308)2.20839927
69Deep venous thrombosis (HP:0002625)2.20271809
70Mitral regurgitation (HP:0001653)2.19200235
71Short 5th finger (HP:0009237)2.19200018
72Hyperextensible skin (HP:0000974)2.19140431
73Palmoplantar hyperkeratosis (HP:0000972)2.18571588
74Ridged nail (HP:0001807)2.18141091
75Elbow flexion contracture (HP:0002987)2.17569632
76Cardiovascular calcification (HP:0011915)2.16447063
77Deviation of the hallux (HP:0010051)2.15984536
78Hypoplastic ischia (HP:0003175)2.15328938
79Coronal craniosynostosis (HP:0004440)2.14877122
80Trismus (HP:0000211)2.14856632
81Infantile muscular hypotonia (HP:0008947)2.14081134
82Fused cervical vertebrae (HP:0002949)2.13938202
83Partial duplication of the phalanx of hand (HP:0009999)2.12655373
84Spinal rigidity (HP:0003306)2.11437966
85Irregular epiphyses (HP:0010582)2.09470317
86Zonular cataract (HP:0010920)2.09216237
87Slender build (HP:0001533)2.08524477
88Ulnar bowing (HP:0003031)2.07451180
89Ankyloglossia (HP:0010296)2.07177994
90Abnormality of oral frenula (HP:0000190)2.06208390
91Broad long bones (HP:0005622)2.06002346
92Palmar hyperkeratosis (HP:0010765)2.03936035
93Abnormality of the pubic bones (HP:0003172)2.03331620
94Hallux valgus (HP:0001822)2.03123163
95Abnormality of the acetabulum (HP:0003170)2.02704181
96Hand muscle atrophy (HP:0009130)2.02662731
97Biconcave vertebral bodies (HP:0004586)2.02462149
98Coxa vara (HP:0002812)2.00820362
99Short middle phalanx of finger (HP:0005819)2.00522142
100Wrist flexion contracture (HP:0001239)1.98535814
101Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.97490693
102Hip contracture (HP:0003273)1.96271358
103Abnormality of skeletal muscle fiber size (HP:0012084)1.95914565
104Hypoplasia of the capital femoral epiphysis (HP:0003090)1.95769948
105Hypoplasia of dental enamel (HP:0006297)1.95286788
106Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.94523754
107Partial duplication of thumb phalanx (HP:0009944)1.93967687
108Disproportionate tall stature (HP:0001519)1.93861467
109Osteolytic defects of the hand bones (HP:0009699)1.93567530
110Osteolytic defects of the phalanges of the hand (HP:0009771)1.93567530
111Bowed forearm bones (HP:0003956)1.93310111
112Bowing of the arm (HP:0006488)1.93310111
113Achilles tendon contracture (HP:0001771)1.93036295
114Inguinal hernia (HP:0000023)1.92580064
115Joint laxity (HP:0001388)1.92321886
116Flat capital femoral epiphysis (HP:0003370)1.90918422
117Abnormal delivery (HP:0001787)1.90505572
118Neoplasm of the heart (HP:0100544)1.90397459
119Abnormal blistering of the skin (HP:0008066)1.90100600
120Breech presentation (HP:0001623)1.89834076
121Back pain (HP:0003418)1.89547685
122Broad face (HP:0000283)1.89523624
123Upper limb amyotrophy (HP:0009129)1.88836959
124Distal upper limb amyotrophy (HP:0007149)1.88836959
125Delayed epiphyseal ossification (HP:0002663)1.87652653
126Abnormality of the distal phalanges of the toes (HP:0010182)1.86786703
127Thoracolumbar scoliosis (HP:0002944)1.86276756
128Vascular calcification (HP:0004934)1.86034862
129Platyspondyly (HP:0000926)1.85387053
130Abnormality of the peritoneum (HP:0002585)1.84542570
131Glossoptosis (HP:0000162)1.84475740
132Dislocated radial head (HP:0003083)1.83713720
133Abnormality of the ischium (HP:0003174)1.82907034
134Embryonal renal neoplasm (HP:0011794)1.82291311
135Nephroblastoma (Wilms tumor) (HP:0002667)1.81734393
136Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.81698484
137Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.80887874
138Short 4th metacarpal (HP:0010044)1.80887874
139Broad phalanx (HP:0006009)1.80729870
140Abnormality of the Achilles tendon (HP:0005109)1.78736273
141Hyperacusis (HP:0010780)1.78116804
142Upper limb muscle weakness (HP:0003484)1.77703785
143Abnormality of the phalanges of the hallux (HP:0010057)1.77661509
144Broad phalanges of the hand (HP:0009768)1.77152054
145Tibial bowing (HP:0002982)1.77017416
146Concave nail (HP:0001598)1.76669426
147Pili torti (HP:0003777)1.72011976
148Protruding ear (HP:0000411)1.70181952
149Generalized amyotrophy (HP:0003700)1.68342266
150Absent epiphyses (HP:0010577)1.68122456
151Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.68122456
152Vertebral arch anomaly (HP:0008438)1.67596498
153Sparse eyelashes (HP:0000653)1.65369729
154Spondylolisthesis (HP:0003302)1.64227878
155Cupped ribs (HP:0000887)1.60333841
156Knee flexion contracture (HP:0006380)1.60235116
157Thin skin (HP:0000963)1.59473684
158Hypotrichosis (HP:0001006)1.58526957
159Arachnodactyly (HP:0001166)1.57601468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.85657082
2ERN14.58104279
3GRK53.90599769
4GRK63.79424183
5TGFBR22.86050208
6ARAF2.81525210
7MST1R2.66974821
8DDR22.53727975
9MET2.45187161
10TRIB32.37695291
11GRK12.32103726
12ADRBK22.30853438
13TYRO32.24579810
14MAPK72.23387248
15LATS22.21751563
16MYLK2.19218895
17CSF1R2.12697936
18PDGFRA1.96067753
19STK101.95000397
20PIM21.90778271
21TESK11.88541336
22MAP3K101.85948420
23SMG11.82987384
24LMTK21.80717153
25MAP3K21.68738189
26LIMK11.63073634
27IRAK31.63073440
28NTRK11.62189883
29SIK11.58542083
30MARK21.57877768
31TTK1.56412617
32BMX1.48184776
33EPHB21.47922769
34WNK11.47468354
35FLT31.46366058
36FGFR31.44681840
37PKN21.44143862
38MAP3K71.37355791
39MOS1.33036385
40MATK1.31781157
41CDC42BPA1.24868990
42PAK41.24285105
43TTN1.24062285
44CAMK41.16666317
45PDGFRB1.14743859
46LATS11.14500645
47CDK71.14251357
48STK381.13832653
49MAP3K31.10437185
50RPS6KA21.09556749
51PRKG21.09474467
52KSR21.09254516
53GRK71.08835179
54TRPM71.07755566
55ADRBK11.01461729
56RIPK11.00639522
57MAP3K60.97492618
58PTK20.92496952
59MAPK120.91736950
60BRAF0.91452988
61MAPKAPK30.91216603
62NEK90.90903883
63ROCK20.89184887
64HIPK20.87075699
65MTOR0.83928620
66CSK0.83825952
67FGFR10.80612000
68MAP3K80.79648795
69DMPK0.79532405
70PTK60.76372271
71EPHA20.75181711
72ERBB40.74689125
73ALK0.72226025
74INSR0.71993502
75MAP2K60.66361270
76PRPF4B0.65475567
77PAK20.64450618
78EEF2K0.62762813
79NME20.62247743
80PBK0.61176504
81AKT20.60641537
82PIK3CA0.59750825
83DAPK30.59668254
84STK240.58628775
85ROCK10.58620215
86MAP3K120.57319698
87CHEK20.55883365
88RET0.55813867
89ERBB20.54935602
90MELK0.53412564
91RPS6KL10.53062245
92RPS6KC10.53062245
93STK38L0.52872193
94STK30.52431868
95MAP3K90.52343907
96ITK0.52015649
97ABL20.51909180
98NTRK20.51785883
99MAP3K10.51223651
100IGF1R0.50774377
101TAOK20.48373245
102LRRK20.47059256
103RPS6KB20.46152022
104TESK20.46082220
105PRKCI0.45800487
106CHEK10.45513293
107CAMK2G0.43802799
108PRKCH0.43638474
109MST40.42947759
110NEK10.42229651
111CDK40.41862235
112PAK30.41082024
113SIK20.40166979
114MAPK110.40163585
115EIF2AK20.39849557
116RAF10.38562687
117ICK0.37546419
118FER0.35852392
119MAPK10.35481496
120PIK3CG0.35389739
121AURKA0.35193950
122PRKD20.35099081
123BRSK10.34253463
124SRC0.34212960
125EPHA30.32579568
126FGFR40.32319548
127FGFR20.31983816
128AKT30.31827896
129MAPK40.31600819
130CDK90.31230311
131HCK0.30956509
132RPS6KA60.30786720
133CDC70.30597696
134PLK10.29788868
135CLK10.29076675
136CDK60.28638015
137NEK20.27815238
138EPHB10.27617753
139CDK80.26192407
140MAPK100.25938651
141PRKD10.25817519
142GSK3A0.24939252
143CAMK1D0.24597776
144CDK20.24184663
145FYN0.19288667
146MAPK30.18993330
147KIT0.18911032
148CSNK1E0.18655026
149MAPKAPK20.18371404
150PRKCD0.18322245
151MAPK140.18053665
152PAK10.17761272
153BLK0.17759381
154ILK0.16907468

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.92795952
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.41970916
3Protein digestion and absorption_Homo sapiens_hsa049743.23243508
4Basal cell carcinoma_Homo sapiens_hsa052172.92951635
5Vitamin B6 metabolism_Homo sapiens_hsa007502.41950576
6Focal adhesion_Homo sapiens_hsa045102.32466719
7Hedgehog signaling pathway_Homo sapiens_hsa043402.21737958
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.86243830
9Proteoglycans in cancer_Homo sapiens_hsa052051.84147341
10Adherens junction_Homo sapiens_hsa045201.80839503
11Hippo signaling pathway_Homo sapiens_hsa043901.76263356
12Other glycan degradation_Homo sapiens_hsa005111.73586023
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.72240344
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.61697991
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.60895175
16MicroRNAs in cancer_Homo sapiens_hsa052061.60660492
17N-Glycan biosynthesis_Homo sapiens_hsa005101.58643902
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.57885216
19Thyroid cancer_Homo sapiens_hsa052161.54163327
20Regulation of actin cytoskeleton_Homo sapiens_hsa048101.52322204
21Malaria_Homo sapiens_hsa051441.49466677
22Pathways in cancer_Homo sapiens_hsa052001.49230488
23Steroid biosynthesis_Homo sapiens_hsa001001.46654858
24PI3K-Akt signaling pathway_Homo sapiens_hsa041511.45205439
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44180832
26Wnt signaling pathway_Homo sapiens_hsa043101.43233309
27Small cell lung cancer_Homo sapiens_hsa052221.43005731
28TGF-beta signaling pathway_Homo sapiens_hsa043501.35982052
29Prion diseases_Homo sapiens_hsa050201.34907732
30Primary immunodeficiency_Homo sapiens_hsa053401.31578525
31Arachidonic acid metabolism_Homo sapiens_hsa005901.31371795
32mTOR signaling pathway_Homo sapiens_hsa041501.30903574
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24230661
34Amoebiasis_Homo sapiens_hsa051461.22776991
35Pentose phosphate pathway_Homo sapiens_hsa000301.21131027
36Notch signaling pathway_Homo sapiens_hsa043301.20575219
37Rap1 signaling pathway_Homo sapiens_hsa040151.18767828
38Bladder cancer_Homo sapiens_hsa052191.18469932
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.17188435
40Dilated cardiomyopathy_Homo sapiens_hsa054141.16078313
41Fructose and mannose metabolism_Homo sapiens_hsa000511.14296394
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12768918
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.11444987
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.09825018
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.07585734
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.06582338
47HTLV-I infection_Homo sapiens_hsa051661.05873872
48Galactose metabolism_Homo sapiens_hsa000521.05140103
49Colorectal cancer_Homo sapiens_hsa052101.04870949
50Melanogenesis_Homo sapiens_hsa049161.04124311
51Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03624116
52Chronic myeloid leukemia_Homo sapiens_hsa052200.99928387
53Dorso-ventral axis formation_Homo sapiens_hsa043200.99183286
54Biosynthesis of amino acids_Homo sapiens_hsa012300.96708230
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96607142
56Axon guidance_Homo sapiens_hsa043600.95421036
57Acute myeloid leukemia_Homo sapiens_hsa052210.94593265
58Ovarian steroidogenesis_Homo sapiens_hsa049130.94404251
59T cell receptor signaling pathway_Homo sapiens_hsa046600.92421433
60Linoleic acid metabolism_Homo sapiens_hsa005910.90416049
61Lysine degradation_Homo sapiens_hsa003100.90324997
62Sphingolipid metabolism_Homo sapiens_hsa006000.89973996
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.89067721
64Pancreatic cancer_Homo sapiens_hsa052120.89019972
65Starch and sucrose metabolism_Homo sapiens_hsa005000.88903554
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87262642
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86533078
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.85382588
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84423394
70Prostate cancer_Homo sapiens_hsa052150.83096234
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82767797
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82157628
73Shigellosis_Homo sapiens_hsa051310.79896019
74Vibrio cholerae infection_Homo sapiens_hsa051100.79366026
75Melanoma_Homo sapiens_hsa052180.78169334
76Choline metabolism in cancer_Homo sapiens_hsa052310.77657942
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76347790
78Ras signaling pathway_Homo sapiens_hsa040140.76289988
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72236521
80VEGF signaling pathway_Homo sapiens_hsa043700.71308086
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70754101
82Endometrial cancer_Homo sapiens_hsa052130.69260862
83Non-small cell lung cancer_Homo sapiens_hsa052230.68984083
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68901586
85Toxoplasmosis_Homo sapiens_hsa051450.68490701
86ErbB signaling pathway_Homo sapiens_hsa040120.67666761
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67649167
88Platelet activation_Homo sapiens_hsa046110.67341213
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66168035
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.65627513
91p53 signaling pathway_Homo sapiens_hsa041150.65548404
92Glioma_Homo sapiens_hsa052140.62665744
93Tight junction_Homo sapiens_hsa045300.62040859
94Viral myocarditis_Homo sapiens_hsa054160.60657774
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60567704
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58641570
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.58614282
98Gap junction_Homo sapiens_hsa045400.58139807
99Lysosome_Homo sapiens_hsa041420.58006751
100Renal cell carcinoma_Homo sapiens_hsa052110.57672795
101GnRH signaling pathway_Homo sapiens_hsa049120.57652858
102Arginine and proline metabolism_Homo sapiens_hsa003300.56743873
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55776411
104Complement and coagulation cascades_Homo sapiens_hsa046100.55298111
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55189015
106Endocytosis_Homo sapiens_hsa041440.53065072
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52603552
108Cell cycle_Homo sapiens_hsa041100.52353775
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50828678
110Thyroid hormone synthesis_Homo sapiens_hsa049180.49951757
111Apoptosis_Homo sapiens_hsa042100.49809187
112Insulin signaling pathway_Homo sapiens_hsa049100.49738154
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49516156
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.49032627
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.48637747
116AMPK signaling pathway_Homo sapiens_hsa041520.48218622
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47854996
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47848959
119HIF-1 signaling pathway_Homo sapiens_hsa040660.47552248
120TNF signaling pathway_Homo sapiens_hsa046680.45619693
121Salmonella infection_Homo sapiens_hsa051320.45205153
122Insulin resistance_Homo sapiens_hsa049310.45067598
123Bile secretion_Homo sapiens_hsa049760.44474141
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43899152
125Hematopoietic cell lineage_Homo sapiens_hsa046400.43723140
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42475408
127Vitamin digestion and absorption_Homo sapiens_hsa049770.41748895
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41051950
129Folate biosynthesis_Homo sapiens_hsa007900.40268730
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40264065
131MAPK signaling pathway_Homo sapiens_hsa040100.39594263
132cAMP signaling pathway_Homo sapiens_hsa040240.39398396
133Inositol phosphate metabolism_Homo sapiens_hsa005620.39113284
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.37851636
135Glucagon signaling pathway_Homo sapiens_hsa049220.37272104
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30841363
137Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30352694
138PPAR signaling pathway_Homo sapiens_hsa033200.30206263
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30199209

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