ART4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.86637255
2ribosomal small subunit assembly (GO:0000028)7.85828271
3protoporphyrinogen IX metabolic process (GO:0046501)7.75921663
4definitive hemopoiesis (GO:0060216)7.66985931
5drug catabolic process (GO:0042737)7.17463592
6protoporphyrinogen IX biosynthetic process (GO:0006782)7.12766753
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.90858305
8viral transcription (GO:0019083)6.71613445
9translational termination (GO:0006415)6.45348194
10negative regulation of fibrinolysis (GO:0051918)6.25123781
11regulation of fibrinolysis (GO:0051917)6.10501014
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.84775840
13L-phenylalanine catabolic process (GO:0006559)5.84775840
14ribosomal small subunit biogenesis (GO:0042274)5.69662274
15negative regulation of erythrocyte differentiation (GO:0045647)5.66759831
16glyoxylate metabolic process (GO:0046487)5.60352045
17translational elongation (GO:0006414)5.54604490
18aromatic amino acid family catabolic process (GO:0009074)5.53820311
19megakaryocyte development (GO:0035855)5.49730820
20heme biosynthetic process (GO:0006783)5.47126036
21S-adenosylmethionine metabolic process (GO:0046500)5.35387215
22erythrocyte maturation (GO:0043249)5.32241903
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.29913885
24indole-containing compound catabolic process (GO:0042436)5.26304286
25indolalkylamine catabolic process (GO:0046218)5.26304286
26tryptophan catabolic process (GO:0006569)5.26304286
27porphyrin-containing compound biosynthetic process (GO:0006779)5.26156238
28epoxygenase P450 pathway (GO:0019373)5.18737253
29protein targeting to ER (GO:0045047)5.16745554
30cotranslational protein targeting to membrane (GO:0006613)5.15523805
31establishment of protein localization to endoplasmic reticulum (GO:0072599)4.97770492
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.97327820
33erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.97008284
34L-phenylalanine metabolic process (GO:0006558)4.97008284
35cellular glucuronidation (GO:0052695)4.96241159
36protein localization to endoplasmic reticulum (GO:0070972)4.89159023
37oxidative demethylation (GO:0070989)4.84126061
38omega-hydroxylase P450 pathway (GO:0097267)4.83806275
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.83271205
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.83271205
41uronic acid metabolic process (GO:0006063)4.81495496
42glucuronate metabolic process (GO:0019585)4.81495496
43tetrapyrrole biosynthetic process (GO:0033014)4.79415394
44viral life cycle (GO:0019058)4.79233987
45cellular protein complex disassembly (GO:0043624)4.74182638
46regulation of protein activation cascade (GO:2000257)4.67375309
47tryptophan metabolic process (GO:0006568)4.61371096
48bile acid biosynthetic process (GO:0006699)4.54457651
49maturation of SSU-rRNA (GO:0030490)4.53660660
50heme metabolic process (GO:0042168)4.46766289
51drug metabolic process (GO:0017144)4.45548158
52translational initiation (GO:0006413)4.38996404
53regulation of complement activation (GO:0030449)4.38741615
54positive regulation of gamma-delta T cell activation (GO:0046645)4.38011379
55kynurenine metabolic process (GO:0070189)4.37049775
56L-methionine salvage (GO:0071267)4.27954283
57L-methionine biosynthetic process (GO:0071265)4.27954283
58amino acid salvage (GO:0043102)4.27954283
59embryonic hemopoiesis (GO:0035162)4.27805419
60porphyrin-containing compound metabolic process (GO:0006778)4.27415315
61peptidyl-glutamic acid carboxylation (GO:0017187)4.26747714
62protein carboxylation (GO:0018214)4.26747714
63protein complex disassembly (GO:0043241)4.26526611
64cellular ketone body metabolic process (GO:0046950)4.22289010
65bile acid metabolic process (GO:0008206)4.10868340
66platelet dense granule organization (GO:0060155)4.10237983
67serine family amino acid catabolic process (GO:0009071)4.08855318
68indolalkylamine metabolic process (GO:0006586)4.06369305
69amino-acid betaine metabolic process (GO:0006577)4.06005228
70phenylpropanoid metabolic process (GO:0009698)4.05440249
71regulation of triglyceride catabolic process (GO:0010896)4.05215799
72myeloid cell development (GO:0061515)4.04058586
73complement activation, alternative pathway (GO:0006957)3.96855279
74aromatic amino acid family metabolic process (GO:0009072)3.96463413
75antigen processing and presentation of endogenous antigen (GO:0019883)3.95682831
76regulation of natural killer cell differentiation (GO:0032823)3.94947778
77intestinal cholesterol absorption (GO:0030299)3.94609415
78fibrinolysis (GO:0042730)3.94548734
79negative regulation of sterol transport (GO:0032372)3.90957670
80negative regulation of cholesterol transport (GO:0032375)3.90957670
81macromolecular complex disassembly (GO:0032984)3.90120465
82ethanol oxidation (GO:0006069)3.87878265
83alkaloid metabolic process (GO:0009820)3.76868980
84bile acid and bile salt transport (GO:0015721)3.76254318
85response to interferon-alpha (GO:0035455)3.75159424
86erythrocyte differentiation (GO:0030218)3.74745063
87tyrosine metabolic process (GO:0006570)3.73672707
88erythrocyte development (GO:0048821)3.72314582
89regulation of erythrocyte differentiation (GO:0045646)3.71878998
90ketone body metabolic process (GO:1902224)3.69804877
91positive regulation of natural killer cell differentiation (GO:0032825)3.69690180
92antigen processing and presentation via MHC class Ib (GO:0002475)3.69377349
93regulation of plasminogen activation (GO:0010755)3.66847281
94heme transport (GO:0015886)3.66039017
95regulation of gamma-delta T cell differentiation (GO:0045586)3.64306444
96triglyceride homeostasis (GO:0070328)3.63586116
97acylglycerol homeostasis (GO:0055090)3.63586116
98amine catabolic process (GO:0009310)3.61644790
99cellular biogenic amine catabolic process (GO:0042402)3.61644790
100hemoglobin metabolic process (GO:0020027)3.57446073
101nuclear-transcribed mRNA catabolic process (GO:0000956)3.54730553
102* arginine metabolic process (GO:0006525)3.54023185
103flavonoid metabolic process (GO:0009812)3.53266634
104heparin biosynthetic process (GO:0030210)3.52889289
105heparin metabolic process (GO:0030202)3.52889289
106glycine metabolic process (GO:0006544)3.50708029
107high-density lipoprotein particle remodeling (GO:0034375)3.49671229
108protein targeting to membrane (GO:0006612)3.48525614
109response to interferon-beta (GO:0035456)3.45805374
110secretory granule organization (GO:0033363)3.42415733
111mRNA catabolic process (GO:0006402)3.41709836
112negative regulation of viral entry into host cell (GO:0046597)3.41650169
113regulation of gamma-delta T cell activation (GO:0046643)3.40496846
114negative regulation of hemostasis (GO:1900047)3.37667567
115negative regulation of blood coagulation (GO:0030195)3.37667567
116alpha-amino acid catabolic process (GO:1901606)3.34783177
117methionine biosynthetic process (GO:0009086)3.34359963
118negative regulation of protein activation cascade (GO:2000258)3.34025391
119water-soluble vitamin biosynthetic process (GO:0042364)3.32038282
120benzene-containing compound metabolic process (GO:0042537)3.27272702
121reverse cholesterol transport (GO:0043691)3.26016134
122ribosomal large subunit biogenesis (GO:0042273)3.24457882
123RNA catabolic process (GO:0006401)3.24294052
124granulocyte differentiation (GO:0030851)3.23651081
125T cell homeostasis (GO:0043029)3.23248190
126lymph node development (GO:0048535)3.22697699
127dopamine transport (GO:0015872)3.21137483
128very-low-density lipoprotein particle assembly (GO:0034379)3.19832129
129ethanol metabolic process (GO:0006067)3.18602717
130drug transmembrane transport (GO:0006855)3.16932301
131cysteine metabolic process (GO:0006534)3.15629843
132Peyers patch development (GO:0048541)3.14980125
133mucosal-associated lymphoid tissue development (GO:0048537)3.14980125
134plasma lipoprotein particle remodeling (GO:0034369)3.13810264
135protein-lipid complex remodeling (GO:0034368)3.13810264
136macromolecular complex remodeling (GO:0034367)3.13810264
137negative regulation of coagulation (GO:0050819)3.11957946
138behavioral response to nicotine (GO:0035095)3.11448681
139arginine catabolic process (GO:0006527)3.10696202
140triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.10431014
141xenobiotic metabolic process (GO:0006805)3.09907825
142vitamin biosynthetic process (GO:0009110)3.09085674
143positive regulation of granulocyte differentiation (GO:0030854)3.06104822
144serine family amino acid metabolic process (GO:0009069)3.04786317
145methionine metabolic process (GO:0006555)3.03645330
146imidazole-containing compound metabolic process (GO:0052803)3.01327707
147peptidyl-glutamic acid modification (GO:0018200)2.98822136
148tetrapyrrole metabolic process (GO:0033013)2.96197217
149positive regulation of blood coagulation (GO:0030194)2.96071021
150positive regulation of hemostasis (GO:1900048)2.96071021
151regulation of hexokinase activity (GO:1903299)2.96065272
152regulation of glucokinase activity (GO:0033131)2.96065272
153cellular amino acid catabolic process (GO:0009063)2.95522398
154sodium-independent organic anion transport (GO:0043252)2.94358958
155protein activation cascade (GO:0072376)2.92983256
156deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92764565
157xenobiotic catabolic process (GO:0042178)2.92585715
158endosome to melanosome transport (GO:0035646)2.91708588
159endosome to pigment granule transport (GO:0043485)2.91708588
160cytolysis (GO:0019835)2.91627509
161negative regulation of wound healing (GO:0061045)2.91259829
162phospholipid homeostasis (GO:0055091)2.90824440
163cholesterol efflux (GO:0033344)2.89471409
164positive regulation of erythrocyte differentiation (GO:0045648)2.89137453
165negative regulation of complement activation (GO:0045916)2.86681189
166fat-soluble vitamin biosynthetic process (GO:0042362)2.86133066
167DNA unwinding involved in DNA replication (GO:0006268)2.84969824
168fucose catabolic process (GO:0019317)2.84810323
169L-fucose metabolic process (GO:0042354)2.84810323
170L-fucose catabolic process (GO:0042355)2.84810323
171formation of translation preinitiation complex (GO:0001731)2.84235107
172cellular response to thyroid hormone stimulus (GO:0097067)2.81709278
173negative regulation of bone mineralization (GO:0030502)2.80331129
174telomere maintenance via telomerase (GO:0007004)2.80090622
175response to type I interferon (GO:0034340)2.78124822
176one-carbon compound transport (GO:0019755)2.69508528
177positive regulation of B cell differentiation (GO:0045579)2.68828221
1783-UTR-mediated mRNA stabilization (GO:0070935)2.68148527
179type I interferon signaling pathway (GO:0060337)2.67123758
180cellular response to type I interferon (GO:0071357)2.67123758
181purine-containing compound salvage (GO:0043101)2.65841277
182execution phase of apoptosis (GO:0097194)2.65777187
183thrombin receptor signaling pathway (GO:0070493)2.64724599
184translation (GO:0006412)2.64473059
185natural killer cell differentiation (GO:0001779)2.61998929
186hemopoiesis (GO:0030097)2.61321773
187valine metabolic process (GO:0006573)2.59089239
188lymphoid progenitor cell differentiation (GO:0002320)2.58619598
189phospholipid scrambling (GO:0017121)2.56580674
190regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.56351281
191leukocyte homeostasis (GO:0001776)2.56138818
192regulation of necroptotic process (GO:0060544)2.53316157
193negative regulation of biomineral tissue development (GO:0070168)2.51316924
194lymphocyte homeostasis (GO:0002260)2.50294724
195positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.49180616
196negative regulation of type I interferon production (GO:0032480)2.46408342
197tRNA methylation (GO:0030488)2.44369414
198regulation of viral entry into host cell (GO:0046596)2.43491214
199blood coagulation, intrinsic pathway (GO:0007597)2.43138636

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human5.34418278
2GATA1_22025678_ChIP-Seq_K562_Human4.53820916
3E2F7_22180533_ChIP-Seq_HELA_Human4.29566855
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.21269592
5ZNF274_21170338_ChIP-Seq_K562_Hela3.45793141
6TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.92580814
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.90794671
8IGF1R_20145208_ChIP-Seq_DFB_Human2.70488100
9TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.60517867
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56453899
11* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.55242399
12* GATA1_19941827_ChIP-Seq_MEL_Mouse2.55209187
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.53884649
14MYC_22102868_ChIP-Seq_BL_Human2.51248355
15VDR_22108803_ChIP-Seq_LS180_Human2.51126537
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.49419768
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.44848041
18GATA1_19941826_ChIP-Seq_K562_Human2.42752362
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.40787203
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37519530
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24982187
22LXR_22158963_ChIP-Seq_LIVER_Mouse2.24347140
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.22821670
24GATA1_22383799_ChIP-Seq_G1ME_Mouse2.21257087
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.18416850
26MYC_18555785_ChIP-Seq_MESCs_Mouse2.18364461
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.18336211
28VDR_21846776_ChIP-Seq_THP-1_Human2.16258288
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14336058
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.12777692
31GBX2_23144817_ChIP-Seq_PC3_Human2.06481107
32MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04538909
33TAF15_26573619_Chip-Seq_HEK293_Human1.99982467
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.96686312
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.94272148
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.93928203
37* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.88037349
38ER_23166858_ChIP-Seq_MCF-7_Human1.85584029
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85183546
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83852908
41ERG_20887958_ChIP-Seq_HPC-7_Mouse1.83582914
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81216117
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80532247
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.80428275
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79691445
46P300_19829295_ChIP-Seq_ESCs_Human1.79545521
47GATA2_22383799_ChIP-Seq_G1ME_Mouse1.76595629
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76158890
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.75876764
50ZNF263_19887448_ChIP-Seq_K562_Human1.73296689
51TP63_17297297_ChIP-ChIP_HaCaT_Human1.72786761
52GATA2_19941826_ChIP-Seq_K562_Human1.72698795
53TCF7_22412390_ChIP-Seq_EML_Mouse1.70320325
54NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.69173026
55IRF1_19129219_ChIP-ChIP_H3396_Human1.69123277
56BCAT_22108803_ChIP-Seq_LS180_Human1.67244217
57FUS_26573619_Chip-Seq_HEK293_Human1.67080302
58MAF_26560356_Chip-Seq_TH1_Human1.66823004
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65762832
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63123370
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60204139
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57354413
63CBP_20019798_ChIP-Seq_JUKART_Human1.56329282
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56329282
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55371425
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54151577
67* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.54085540
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.53632070
69KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.53013689
70UTX_26944678_Chip-Seq_JUKART_Human1.52637165
71SPI1_23547873_ChIP-Seq_NB4_Human1.51848544
72RUNX_20019798_ChIP-Seq_JUKART_Human1.51830938
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50877181
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.50477315
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.50477315
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.49632173
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48152546
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.47600372
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.47343185
80NANOG_19829295_ChIP-Seq_ESCs_Human1.45922747
81SOX2_19829295_ChIP-Seq_ESCs_Human1.45922747
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43512561
83MYB_26560356_Chip-Seq_TH2_Human1.41857349
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41806873
85* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41802070
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41488177
87STAT3_23295773_ChIP-Seq_U87_Human1.40869813
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39969111
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.39873953
90EWS_26573619_Chip-Seq_HEK293_Human1.39804852
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.39342335
92TP53_22573176_ChIP-Seq_HFKS_Human1.39292821
93* AR_20517297_ChIP-Seq_VCAP_Human1.38351063
94MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38062205
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37842677
96TCF4_22108803_ChIP-Seq_LS180_Human1.37173864
97ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36821306
98MYB_26560356_Chip-Seq_TH1_Human1.36604842
99VDR_24763502_ChIP-Seq_THP-1_Human1.36379233
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36265597
101* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35553770
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.34768662
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34670239
104MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33952222
105ELK3_25401928_ChIP-Seq_HUVEC_Human1.33638858
106HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33270260
107TCF4_23295773_ChIP-Seq_U87_Human1.32491025
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32248960
109BP1_19119308_ChIP-ChIP_Hs578T_Human1.31969761
110PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.30100511
111* CDX2_22108803_ChIP-Seq_LS180_Human1.29600904
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29478055
113E2F4_17652178_ChIP-ChIP_JURKAT_Human1.27932297
114AR_25329375_ChIP-Seq_VCAP_Human1.27433351
115* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26989188
116FOXM1_23109430_ChIP-Seq_U2OS_Human1.26271316
117FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25612697
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24649136
119VDR_23849224_ChIP-Seq_CD4+_Human1.24493941
120GATA3_21878914_ChIP-Seq_MCF-7_Human1.24397620
121BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22888238
122CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22268500
123NCOR1_26117541_ChIP-Seq_K562_Human1.21624412
124NCOR_22424771_ChIP-Seq_293T_Human1.21621739
125FOXP3_21729870_ChIP-Seq_TREG_Human1.21550088
126* HNF4A_19822575_ChIP-Seq_HepG2_Human1.20603951
127KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20272759
128MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20268119
129HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19818744
130NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19755814
131FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17522612
132SMAD4_21799915_ChIP-Seq_A2780_Human1.16985256
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16693587
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16557610
135PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15984599
136* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14558938
137SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13799793
138SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13579366
139CIITA_25753668_ChIP-Seq_RAJI_Human1.13462966
140HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13161101
141RUNX2_22187159_ChIP-Seq_PCA_Human1.13027866
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12698793
143* GATA2_21666600_ChIP-Seq_HMVEC_Human1.11872023
144AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10867682
145FOXH1_21741376_ChIP-Seq_EPCs_Human1.10649386
146STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10532129
147SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10092598
148NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09597135
149PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09058522
150BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08693153
151SMAD4_21741376_ChIP-Seq_EPCs_Human1.08604629
152GATA4_25053715_ChIP-Seq_YYC3_Human1.08216643
153ETS1_22383799_ChIP-Seq_G1ME_Mouse1.08169153
154CRX_20693478_ChIP-Seq_RETINA_Mouse1.07449344
155SRF_21415370_ChIP-Seq_HL-1_Mouse1.07333950
156EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06876653
157TP53_16413492_ChIP-PET_HCT116_Human1.06613874
158CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06133439
159FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05979961
160NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05928652
161SMAD3_21741376_ChIP-Seq_EPCs_Human1.05858766
162ETS1_20019798_ChIP-Seq_JURKAT_Human1.05698480
163GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05653329
164KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05279329
165XRN2_22483619_ChIP-Seq_HELA_Human1.05005766
166STAT3_18555785_Chip-Seq_ESCs_Mouse1.04947581
167RXR_22158963_ChIP-Seq_LIVER_Mouse1.04518882
168EGR1_19374776_ChIP-ChIP_THP-1_Human1.04267888
169TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04180371
170HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04020571
171MAF_26560356_Chip-Seq_TH2_Human1.03879226
172MYC_19829295_ChIP-Seq_ESCs_Human1.02600004
173FOXA2_19822575_ChIP-Seq_HepG2_Human1.01989964
174HTT_18923047_ChIP-ChIP_STHdh_Human1.01423937
175TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99563926
176NANOG_18555785_Chip-Seq_ESCs_Mouse0.99216394
177E2F1_21310950_ChIP-Seq_MCF-7_Human0.99049749
178TAF2_19829295_ChIP-Seq_ESCs_Human0.98986925
179NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98886271
180THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98801811
181* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98083949
182P53_22387025_ChIP-Seq_ESCs_Mouse0.97142184
183SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96824885
184ETV1_20927104_ChIP-Seq_GIST48_Human0.96277671
185SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96036533
186EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95739679
187* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95580306
188CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95288082
189E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95196177
190AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95033759
191CEBPB_22108803_ChIP-Seq_LS180_Human0.93920786
192PHF8_20622853_ChIP-Seq_HELA_Human0.93286029
193OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93190321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis5.74509267
2MP0004147_increased_porphyrin_level5.68354451
3MP0003656_abnormal_erythrocyte_physiolo5.51216083
4MP0005365_abnormal_bile_salt4.51056270
5MP0005360_urolithiasis3.70964436
6MP0010368_abnormal_lymphatic_system3.31651102
7MP0003252_abnormal_bile_duct3.30956721
8MP0002396_abnormal_hematopoietic_system3.07253005
9MP0001545_abnormal_hematopoietic_system2.90979284
10MP0005397_hematopoietic_system_phenotyp2.90979284
11MP0004808_abnormal_hematopoietic_stem2.73866878
12MP0000685_abnormal_immune_system2.73761916
13MP0002876_abnormal_thyroid_physiology2.68486000
14MP0005464_abnormal_platelet_physiology2.57051447
15MP0010329_abnormal_lipoprotein_level2.51375056
16MP0000465_gastrointestinal_hemorrhage2.29819752
17MP0009697_abnormal_copulation2.16894703
18MP0003763_abnormal_thymus_physiology2.07268353
19MP0005332_abnormal_amino_acid2.03581464
20MP0000490_abnormal_crypts_of2.03092779
21MP0006054_spinal_hemorrhage1.99053382
22MP0002398_abnormal_bone_marrow1.96044374
23MP0009379_abnormal_foot_pigmentation1.94614079
24MP0001835_abnormal_antigen_presentation1.94256771
25MP0005167_abnormal_blood-brain_barrier1.93362019
26MP0003724_increased_susceptibility_to1.91788827
27MP0005671_abnormal_response_to1.90777654
28MP0009785_altered_susceptibility_to1.86468147
29MP0002166_altered_tumor_susceptibility1.83562548
30MP0005084_abnormal_gallbladder_morpholo1.83312973
31MP0001879_abnormal_lymphatic_vessel1.81275319
32MP0002722_abnormal_immune_system1.70944522
33MP0005025_abnormal_response_to1.67415508
34MP0005551_abnormal_eye_electrophysiolog1.64708081
35MP0004142_abnormal_muscle_tone1.62637092
36MP0010155_abnormal_intestine_physiology1.61653443
37MP0000689_abnormal_spleen_morphology1.60579717
38MP0002095_abnormal_skin_pigmentation1.57255087
39MP0001764_abnormal_homeostasis1.56415021
40MP0010094_abnormal_chromosome_stability1.55845236
41MP0003011_delayed_dark_adaptation1.55464966
42MP0005075_abnormal_melanosome_morpholog1.55258775
43MP0002877_abnormal_melanocyte_morpholog1.54174397
44MP0002429_abnormal_blood_cell1.50999529
45MP0008872_abnormal_physiological_respon1.49716789
46MP0009278_abnormal_bone_marrow1.44163578
47MP0000703_abnormal_thymus_morphology1.40956558
48MP0000716_abnormal_immune_system1.37291063
49MP0001800_abnormal_humoral_immune1.36189419
50MP0003300_gastrointestinal_ulcer1.36136425
51MP0005646_abnormal_pituitary_gland1.34339187
52MP0009764_decreased_sensitivity_to1.34157950
53MP0005174_abnormal_tail_pigmentation1.32548769
54MP0003436_decreased_susceptibility_to1.32175311
55MP0003111_abnormal_nucleus_morphology1.31403117
56MP0003868_abnormal_feces_composition1.28214388
57MP0002009_preneoplasia1.26840754
58MP0002118_abnormal_lipid_homeostasis1.26694051
59MP0002420_abnormal_adaptive_immunity1.26179383
60MP0002132_abnormal_respiratory_system1.25803084
61MP0001819_abnormal_immune_cell1.24711093
62MP0003878_abnormal_ear_physiology1.24267449
63MP0005377_hearing/vestibular/ear_phenot1.24267449
64MP0002837_dystrophic_cardiac_calcinosis1.23743297
65MP0000609_abnormal_liver_physiology1.23637741
66MP0002452_abnormal_antigen_presenting1.22996548
67MP0008877_abnormal_DNA_methylation1.22678798
68MP0002723_abnormal_immune_serum1.21060521
69MP0004133_heterotaxia1.20670705
70MP0001790_abnormal_immune_system1.19499150
71MP0005387_immune_system_phenotype1.19499150
72MP0002148_abnormal_hypersensitivity_rea1.13817763
73MP0003567_abnormal_fetal_cardiomyocyte1.13598211
74MP0002006_tumorigenesis1.10152893
75MP0004947_skin_inflammation1.09863790
76MP0005085_abnormal_gallbladder_physiolo1.09141396
77MP0009765_abnormal_xenobiotic_induced1.08703064
78MP0005000_abnormal_immune_tolerance1.08283784
79MP0003828_pulmonary_edema1.08171265
80MP0003646_muscle_fatigue1.06537487
81MP0005636_abnormal_mineral_homeostasis1.06525793
82MP0003866_abnormal_defecation1.06493508
83MP0009333_abnormal_splenocyte_physiolog1.06033269
84MP0009931_abnormal_skin_appearance1.05920732
85MP0003191_abnormal_cellular_cholesterol1.04962533
86MP0003718_maternal_effect1.04670870
87MP0000343_altered_response_to1.04470526
88MP0005253_abnormal_eye_physiology1.04286284
89MP0006036_abnormal_mitochondrial_physio1.03749920
90MP0005083_abnormal_biliary_tract1.03656736
91MP0001853_heart_inflammation1.03146770
92MP0002638_abnormal_pupillary_reflex1.02155164
93MP0002102_abnormal_ear_morphology1.02030974
94MP0003186_abnormal_redox_activity1.01495186
95MP0004019_abnormal_vitamin_homeostasis0.99695160
96MP0001666_abnormal_nutrient_absorption0.99582517
97MP0006072_abnormal_retinal_apoptosis0.96861978
98MP0004130_abnormal_muscle_cell0.96759217
99MP0009643_abnormal_urine_homeostasis0.96387096
100MP0001845_abnormal_inflammatory_respons0.95783643
101MP0005379_endocrine/exocrine_gland_phen0.94661864
102MP0002019_abnormal_tumor_incidence0.94589594
103MP0005645_abnormal_hypothalamus_physiol0.92844937
104MP0005395_other_phenotype0.91571485
105MP0003122_maternal_imprinting0.90939788
106MP0003077_abnormal_cell_cycle0.90547830
107MP0003806_abnormal_nucleotide_metabolis0.90432706
108MP0008469_abnormal_protein_level0.89823079
109MP0002405_respiratory_system_inflammati0.89039704
110MP0005451_abnormal_body_composition0.88433472
111MP0006276_abnormal_autonomic_nervous0.88137438
112MP0002419_abnormal_innate_immunity0.87764819
113MP0006292_abnormal_olfactory_placode0.87403672
114MP0003136_yellow_coat_color0.86815306
115MP0004043_abnormal_pH_regulation0.86672147
116MP0009763_increased_sensitivity_to0.86515329
117MP0002928_abnormal_bile_duct0.86272893
118MP0002938_white_spotting0.85608820
119MP0001191_abnormal_skin_condition0.83596909
120MP0002168_other_aberrant_phenotype0.82403584
121MP0001873_stomach_inflammation0.82256725
122MP0001501_abnormal_sleep_pattern0.82238300
123MP0003638_abnormal_response/metabolism_0.82137610
124MP0003787_abnormal_imprinting0.81260600
125MP0008058_abnormal_DNA_repair0.81150755
126MP0008775_abnormal_heart_ventricle0.80317340
127MP0005501_abnormal_skin_physiology0.80290565
128MP0002139_abnormal_hepatobiliary_system0.78384089
129MP0001986_abnormal_taste_sensitivity0.78057656
130MP0005187_abnormal_penis_morphology0.77884646
131MP0005385_cardiovascular_system_phenoty0.77415381
132MP0001544_abnormal_cardiovascular_syste0.77415381
133MP0009780_abnormal_chondrocyte_physiolo0.76727327
134MP0005408_hypopigmentation0.76595701
135MP0000313_abnormal_cell_death0.76448650
136MP0002060_abnormal_skin_morphology0.76442825
137MP0003943_abnormal_hepatobiliary_system0.75437104
138MP0001324_abnormal_eye_pigmentation0.74476799
139MP0010386_abnormal_urinary_bladder0.74321824
140MP0000598_abnormal_liver_morphology0.74220754
141MP0010352_gastrointestinal_tract_polyps0.73703941
142MP0001661_extended_life_span0.73580295
143MP0004145_abnormal_muscle_electrophysio0.73178042
144MP0002138_abnormal_hepatobiliary_system0.73114815
145MP0000477_abnormal_intestine_morphology0.72850869
146MP0004215_abnormal_myocardial_fiber0.72602914
147MP0008875_abnormal_xenobiotic_pharmacok0.71403636
148MP0003566_abnormal_cell_adhesion0.71275588
149MP0005410_abnormal_fertilization0.71233332
150MP0009046_muscle_twitch0.70946807
151MP0002098_abnormal_vibrissa_morphology0.70944780
152MP0003950_abnormal_plasma_membrane0.69885997
153MP0005319_abnormal_enzyme/_coenzyme0.69748996
154MP0004885_abnormal_endolymph0.69047044
155MP0010630_abnormal_cardiac_muscle0.68046853
156MP0004084_abnormal_cardiac_muscle0.66870043
157MP0002282_abnormal_trachea_morphology0.66653576
158MP0003693_abnormal_embryo_hatching0.66646009
159MP0003890_abnormal_embryonic-extraembry0.66486612
160MP0009642_abnormal_blood_homeostasis0.66286657
161MP0001756_abnormal_urination0.66088892
162MP0002909_abnormal_adrenal_gland0.66075633
163MP0005389_reproductive_system_phenotype0.65731739
164MP0005195_abnormal_posterior_eye0.63028233
165MP0002163_abnormal_gland_morphology0.62627267
166MP0005220_abnormal_exocrine_pancreas0.62065897
167MP0002160_abnormal_reproductive_system0.61545351
168MP0000639_abnormal_adrenal_gland0.61169733
169MP0005448_abnormal_energy_balance0.58764899
170MP0000383_abnormal_hair_follicle0.58104441
171MP0002653_abnormal_ependyma_morphology0.58058772
172MP0001968_abnormal_touch/_nociception0.57881101
173MP0000230_abnormal_systemic_arterial0.56497292
174MP0005376_homeostasis/metabolism_phenot0.56096035
175MP0000372_irregular_coat_pigmentation0.55987360
176MP0009745_abnormal_behavioral_response0.55973515
177MP0001919_abnormal_reproductive_system0.55659694
178MP0009840_abnormal_foam_cell0.55214607
179MP0001944_abnormal_pancreas_morphology0.55124481
180MP0002078_abnormal_glucose_homeostasis0.54257926

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)8.98409593
2Microcytic anemia (HP:0001935)5.82276491
3Poikilocytosis (HP:0004447)5.75200208
4Prolonged partial thromboplastin time (HP:0003645)5.66741974
5Abnormality of cells of the erythroid lineage (HP:0012130)5.54710052
6Abnormal number of erythroid precursors (HP:0012131)5.22671528
7Deep venous thrombosis (HP:0002625)5.14546724
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.97677912
9Prolonged bleeding time (HP:0003010)4.87226363
10Hypobetalipoproteinemia (HP:0003563)4.79700124
11Abnormality of aromatic amino acid family metabolism (HP:0004338)4.60674032
12Thrombocytosis (HP:0001894)4.46025223
13Acanthocytosis (HP:0001927)4.32200433
14Reticulocytopenia (HP:0001896)4.24688353
15Complement deficiency (HP:0004431)4.24122008
16Conjugated hyperbilirubinemia (HP:0002908)4.15849418
17Hypochromic microcytic anemia (HP:0004840)4.11879258
18Cellulitis (HP:0100658)3.97502984
19Epistaxis (HP:0000421)3.82895059
20Pallor (HP:0000980)3.69810888
21Joint hemorrhage (HP:0005261)3.65777927
22Polycythemia (HP:0001901)3.62380846
23Aplastic anemia (HP:0001915)3.61603275
24Petechiae (HP:0000967)3.59118301
25Abnormal platelet function (HP:0011869)3.50242385
26Impaired platelet aggregation (HP:0003540)3.50242385
27Abnormality of reticulocytes (HP:0004312)3.45532440
28Macrocytic anemia (HP:0001972)3.30632062
29Hyperbilirubinemia (HP:0002904)3.30232428
30Abnormality of the nasal mucosa (HP:0000433)3.26607937
31Pancreatic cysts (HP:0001737)3.19159556
32Hyperlipoproteinemia (HP:0010980)3.18196484
33Intrahepatic cholestasis (HP:0001406)3.16963080
34Abnormality of the renal cortex (HP:0011035)3.15041960
35Thrombophlebitis (HP:0004418)3.07679567
36Hypochromic anemia (HP:0001931)3.06121272
37Fair hair (HP:0002286)3.01119074
38Reticulocytosis (HP:0001923)3.01007239
39Spontaneous hematomas (HP:0007420)2.98710589
40Hyperglycinemia (HP:0002154)2.98007112
41Onycholysis (HP:0001806)2.95110385
42Renal cortical cysts (HP:0000803)2.91047758
43Hyperglycinuria (HP:0003108)2.89327390
44Bile duct proliferation (HP:0001408)2.88416368
45Abnormal biliary tract physiology (HP:0012439)2.88416368
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.85956304
47IgM deficiency (HP:0002850)2.85871891
48Congenital stationary night blindness (HP:0007642)2.82577498
49Cholelithiasis (HP:0001081)2.82284697
50Recurrent viral infections (HP:0004429)2.82084592
51True hermaphroditism (HP:0010459)2.81536635
52Abnormality of complement system (HP:0005339)2.80469558
53Panhypogammaglobulinemia (HP:0003139)2.80182425
54Pancreatic fibrosis (HP:0100732)2.79130475
55Abnormality of urine glucose concentration (HP:0011016)2.78926682
56Glycosuria (HP:0003076)2.78926682
57Chronic otitis media (HP:0000389)2.71043293
58Nephronophthisis (HP:0000090)2.68719311
59Muscle fiber atrophy (HP:0100295)2.68379046
60Abnormality of glycine metabolism (HP:0010895)2.67526963
61Abnormality of serine family amino acid metabolism (HP:0010894)2.67526963
62Abnormality of midbrain morphology (HP:0002418)2.65662146
63Molar tooth sign on MRI (HP:0002419)2.65662146
64Ketosis (HP:0001946)2.63497587
65Xanthomatosis (HP:0000991)2.63284780
66Pulmonary embolism (HP:0002204)2.62333086
67Menorrhagia (HP:0000132)2.60703384
68Type 2 muscle fiber atrophy (HP:0003554)2.55206948
69Hyperalaninemia (HP:0003348)2.54895236
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54895236
71Abnormality of alanine metabolism (HP:0010916)2.54895236
72Abnormality of methionine metabolism (HP:0010901)2.51770373
73Hypothermia (HP:0002045)2.51750915
74Hypolipoproteinemia (HP:0010981)2.51439612
75Purpura (HP:0000979)2.50861122
76Abnormality of glutamine family amino acid metabolism (HP:0010902)2.49540174
77Amaurosis fugax (HP:0100576)2.48772882
78Delayed CNS myelination (HP:0002188)2.47924473
79Abnormality of the common coagulation pathway (HP:0010990)2.47821069
80Abnormality of the renal medulla (HP:0100957)2.46377351
81Acute myeloid leukemia (HP:0004808)2.46284318
82Abnormality of aspartate family amino acid metabolism (HP:0010899)2.45298320
83Abnormal gallbladder morphology (HP:0012437)2.43900235
84Erythema (HP:0010783)2.40450142
85Chronic hepatic failure (HP:0100626)2.40134238
86Glomerulonephritis (HP:0000099)2.39523449
87Fat malabsorption (HP:0002630)2.38674419
88Abnormality of serum amino acid levels (HP:0003112)2.38480922
89Gingival bleeding (HP:0000225)2.38274061
90Arthropathy (HP:0003040)2.37455002
91Abnormality of T cell physiology (HP:0011840)2.37120082
92Diaphragmatic weakness (HP:0009113)2.36087481
93Enlarged kidneys (HP:0000105)2.35865905
94Agammaglobulinemia (HP:0004432)2.31242914
95Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.29382459
96Myositis (HP:0100614)2.28279581
97Attenuation of retinal blood vessels (HP:0007843)2.27766087
98Pustule (HP:0200039)2.27431650
99Type II lissencephaly (HP:0007260)2.26554321
100Abnormality of transition element cation homeostasis (HP:0011030)2.22122765
101Fatigue (HP:0012378)2.20850774
102Tubular atrophy (HP:0000092)2.19941478
103Hypophosphatemic rickets (HP:0004912)2.18640680
104Ketoacidosis (HP:0001993)2.18112290
105Nasal polyposis (HP:0100582)2.16932565
106Rickets (HP:0002748)2.15705627
107Abnormality of the intrinsic pathway (HP:0010989)2.15212744
108Abnormality of vitamin metabolism (HP:0100508)2.14999359
109Basal cell carcinoma (HP:0002671)2.13153506
110Migraine (HP:0002076)2.11455137
111Abnormality of proline metabolism (HP:0010907)2.10455183
112Hydroxyprolinuria (HP:0003080)2.10455183
113Elevated erythrocyte sedimentation rate (HP:0003565)2.09710763
114Metabolic acidosis (HP:0001942)2.09491244
11511 pairs of ribs (HP:0000878)2.08909313
116Abnormality of T cells (HP:0002843)2.08107978
117Epidermoid cyst (HP:0200040)2.06494517
118Abnormal blistering of the skin (HP:0008066)2.06482812
119Recurrent bronchitis (HP:0002837)2.06436642
120Systemic lupus erythematosus (HP:0002725)2.05820120
121B lymphocytopenia (HP:0010976)2.04795603
122Abnormality of B cell number (HP:0010975)2.04795603
123Methylmalonic acidemia (HP:0002912)2.03488678
124Nausea (HP:0002018)2.03053992
125Increased serum ferritin (HP:0003281)2.03000252
126Steatorrhea (HP:0002570)2.02427526
127Cutaneous photosensitivity (HP:0000992)2.01930026
128Lethargy (HP:0001254)2.01554049
129Paralysis (HP:0003470)2.00259069
130Generalized hypopigmentation of hair (HP:0011358)2.00026150
131Osteomalacia (HP:0002749)1.99539408
132Abnormal platelet volume (HP:0011876)1.99216797
133Abnormal drinking behavior (HP:0030082)1.98385314
134Polydipsia (HP:0001959)1.98385314
135Recurrent fungal infections (HP:0002841)1.96272120
136Hyperventilation (HP:0002883)1.96117269
137Cystic liver disease (HP:0006706)1.96005236
138Abolished electroretinogram (ERG) (HP:0000550)1.95224158
139Facial shape deformation (HP:0011334)1.94663704
140Potter facies (HP:0002009)1.94663704
141Poikiloderma (HP:0001029)1.93750454
142Nephritis (HP:0000123)1.93662416
143Hyperammonemia (HP:0001987)1.92850084
144Weak cry (HP:0001612)1.92627940
145Myelodysplasia (HP:0002863)1.92601998
146Hyperphosphaturia (HP:0003109)1.92310213
147Spontaneous abortion (HP:0005268)1.91966949
148Abnormality of pyrimidine metabolism (HP:0004353)1.91872708
149Decreased central vision (HP:0007663)1.91629511
150Vascular calcification (HP:0004934)1.90672248
151Autoimmune thrombocytopenia (HP:0001973)1.89333840
152Entropion (HP:0000621)1.87973938
153Azoospermia (HP:0000027)1.87644558
154Gastrointestinal inflammation (HP:0004386)1.87603620
155Verrucae (HP:0200043)1.87111171
156Papilloma (HP:0012740)1.87111171
157Interstitial pulmonary disease (HP:0006530)1.85986110
158Generalized aminoaciduria (HP:0002909)1.85938677
159Acute encephalopathy (HP:0006846)1.85519352
160Urticaria (HP:0001025)1.84767076
161Colitis (HP:0002583)1.84695268
162Arterial thrombosis (HP:0004420)1.84399859
163Rough bone trabeculation (HP:0100670)1.83982056
164Hematochezia (HP:0002573)1.82221764
165Cerebral palsy (HP:0100021)1.81428922
166Depressed nasal tip (HP:0000437)1.80836136
167Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80750784
168Reduced antithrombin III activity (HP:0001976)1.79267503
169Congenital hepatic fibrosis (HP:0002612)1.77469400
170Abnormality of sulfur amino acid metabolism (HP:0004339)1.77276474
171Hypoproteinemia (HP:0003075)1.77200539
172Methylmalonic aciduria (HP:0012120)1.76565298
173Birth length less than 3rd percentile (HP:0003561)1.75836185
174Pancytopenia (HP:0001876)1.75273804
175Colon cancer (HP:0003003)1.75162941
176Congenital, generalized hypertrichosis (HP:0004540)1.75071521
177Neutropenia (HP:0001875)1.74694483
178Abnormality of the nasal septum (HP:0000419)1.74609252
179Abnormal hemoglobin (HP:0011902)1.73552712
180Increased mean platelet volume (HP:0011877)1.73121967
181Inflammation of the large intestine (HP:0002037)1.73116379
182Teleangiectasia of the skin (HP:0100585)1.73065694
183Bruising susceptibility (HP:0000978)1.72114072
184Asplenia (HP:0001746)1.69924429
185Lymphoma (HP:0002665)1.65945838
186Skin rash (HP:0000988)1.65479732
187Increased IgE level (HP:0003212)1.64971987
188Abnormality of iron homeostasis (HP:0011031)1.63791145
189IgG deficiency (HP:0004315)1.63696836

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.94663621
2BCKDK4.87973161
3TIE14.31016999
4EEF2K3.74425166
5MAP4K23.09096195
6BMPR1B3.08222325
7NME22.97699515
8TGFBR12.87607601
9MAP4K12.82263782
10TGFBR22.70422038
11INSRR2.62541009
12GRK12.55992199
13PINK12.54024226
14ADRBK22.53349095
15RPS6KB22.33353053
16WNK42.28414990
17KIT2.17255183
18TNIK2.13907681
19CDK192.09698590
20WNK32.07267830
21DAPK21.94111059
22MAPKAPK31.93933737
23PKN21.88080949
24JAK31.87698780
25TYK21.86062240
26IKBKE1.71363799
27MAPKAPK51.70675667
28CAMKK21.59539054
29BTK1.55125211
30LRRK21.55030094
31STK101.54324162
32STK38L1.54267653
33NLK1.51433621
34DYRK31.50274787
35FGFR41.42934853
36MAP2K31.41842813
37MATK1.40777265
38STK241.35323057
39PIK3CA1.34031687
40TRIB31.28612559
41ZAP701.24580675
42FLT31.22825804
43TLK11.19291175
44MAP3K41.18125118
45TEC1.13598748
46STK41.12016844
47SYK1.07364680
48TAOK31.05722880
49STK391.03610556
50TBK11.01906323
51MAPK111.01826172
52MST41.00767123
53MAPK131.00597631
54TRPM70.99754231
55PIM10.99676889
56PRKAA20.99046684
57MUSK0.98771423
58ACVR1B0.98632442
59PTK2B0.97779013
60OXSR10.97307089
61MAP3K110.97006801
62PRKCG0.92228553
63NEK20.91848422
64MYLK0.91561323
65PLK20.91482551
66WNK10.88941886
67ILK0.87365170
68MKNK20.87117714
69WEE10.86529318
70EIF2AK10.86510631
71IKBKB0.85944358
72JAK20.84806711
73ADRBK10.83631197
74PRKCE0.83433709
75BRSK20.82591266
76HIPK20.82054941
77NTRK30.81017158
78PLK40.80381385
79EIF2AK30.80377660
80PAK30.79137773
81ERN10.79057285
82ITK0.76462626
83RPS6KA50.75453973
84GRK60.75053185
85MKNK10.73519517
86PHKG20.72397820
87PHKG10.72397820
88CDC70.72271483
89PIK3CG0.71638142
90FGFR20.71288892
91CASK0.70963415
92MAP2K20.70871348
93PASK0.70727593
94BCR0.69790630
95FER0.69731282
96PRKCQ0.69044878
97LCK0.68496483
98EPHA40.68015989
99VRK10.67486903
100MAP3K30.66086785
101ZAK0.65809343
102RPS6KA40.65647284
103CSF1R0.63140275
104TXK0.62865199
105MAP3K100.62529312
106KDR0.59751007
107CDK60.59557185
108CDK30.58071496
109AURKB0.57983337
110MAP3K10.56506720
111IGF1R0.56158811
112ERBB20.54295518
113ERBB30.54085766
114PRKACA0.53717898
115RPS6KA60.53272220
116LYN0.52901738
117PRKACG0.52340811
118CSNK1G10.52091091
119MAP2K70.51924563
120CAMK1D0.51868980
121DYRK20.51052640
122DYRK1B0.50678703
123MAP2K10.50330624
124CLK10.49972275
125STK160.49891474
126MAP3K70.48984171
127NUAK10.48651771
128PTK60.48647263
129PRKAA10.47780088
130CDK40.47097344
131MAP3K80.46815347
132LATS10.46791306
133CSNK1D0.46088862
134PLK30.45224844
135TNK20.44985073
136MAP2K60.44314358
137CAMK10.44028402
138JAK10.43362896
139CDK80.43309841
140CSNK1A1L0.42917476
141FGFR30.42340428
142ATR0.41607891
143DAPK10.40462987
144RPS6KC10.40248112
145RPS6KL10.40248112
146MAPK150.39772765
147PRKCA0.39645518
148SGK20.39510027
149MAPK120.38379271
150CAMK2A0.38292794
151CSNK1A10.38116754
152TTN0.37184181
153PRKG10.36361373
154GRK70.36283052
155MAPK40.35212379
156ABL10.35051044
157SGK2230.34363913
158SGK4940.34363913
159CHUK0.34289351
160STK30.33022752
161CSNK1G30.32939700
162CSNK1G20.32641986
163RET0.32459327
164MAPKAPK20.31070334
165DAPK30.30523270
166MAPK30.28993212

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.79408719
2Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008604.34721025
3DNA replication_Homo sapiens_hsa030303.03510462
4Butanoate metabolism_Homo sapiens_hsa006502.94311973
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.94048798
6Retinol metabolism_Homo sapiens_hsa008302.90129430
7Steroid hormone biosynthesis_Homo sapiens_hsa001402.54093151
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.53744364
9Linoleic acid metabolism_Homo sapiens_hsa005912.51500855
10Primary immunodeficiency_Homo sapiens_hsa053402.33280455
11Systemic lupus erythematosus_Homo sapiens_hsa053222.29718178
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90587044
13Caffeine metabolism_Homo sapiens_hsa002321.89114183
14Hematopoietic cell lineage_Homo sapiens_hsa046401.83249536
15Measles_Homo sapiens_hsa051621.76364603
16Platelet activation_Homo sapiens_hsa046111.73013306
17Mismatch repair_Homo sapiens_hsa034301.72273241
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71349501
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70627510
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68574383
21Base excision repair_Homo sapiens_hsa034101.65566729
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65500740
23Tyrosine metabolism_Homo sapiens_hsa003501.61839896
24ABC transporters_Homo sapiens_hsa020101.61839436
25Herpes simplex infection_Homo sapiens_hsa051681.58932132
26Phenylalanine metabolism_Homo sapiens_hsa003601.58284096
27Sulfur relay system_Homo sapiens_hsa041221.58146969
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.56771832
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56569883
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.56256638
31Histidine metabolism_Homo sapiens_hsa003401.56046591
32Arginine biosynthesis_Homo sapiens_hsa002201.55026147
33Folate biosynthesis_Homo sapiens_hsa007901.52912047
34Thyroid cancer_Homo sapiens_hsa052161.49143513
35Acute myeloid leukemia_Homo sapiens_hsa052211.48450133
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.46362398
37Fat digestion and absorption_Homo sapiens_hsa049751.37631775
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37623704
39Spliceosome_Homo sapiens_hsa030401.34261552
40Fatty acid degradation_Homo sapiens_hsa000711.34132763
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31420362
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.31077174
43Nitrogen metabolism_Homo sapiens_hsa009101.30154205
44Bile secretion_Homo sapiens_hsa049761.29430824
45Pyrimidine metabolism_Homo sapiens_hsa002401.29091369
46Starch and sucrose metabolism_Homo sapiens_hsa005001.27767967
47B cell receptor signaling pathway_Homo sapiens_hsa046621.26875223
48Arachidonic acid metabolism_Homo sapiens_hsa005901.23261564
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21121290
50Selenocompound metabolism_Homo sapiens_hsa004501.17963341
51Nucleotide excision repair_Homo sapiens_hsa034201.15468596
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08142832
53Cell cycle_Homo sapiens_hsa041101.06675585
54Leishmaniasis_Homo sapiens_hsa051401.04179939
55Fatty acid metabolism_Homo sapiens_hsa012121.00595659
56NF-kappa B signaling pathway_Homo sapiens_hsa040641.00466272
57Malaria_Homo sapiens_hsa051440.99790424
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99779895
59RNA degradation_Homo sapiens_hsa030180.98412681
60p53 signaling pathway_Homo sapiens_hsa041150.96752192
61One carbon pool by folate_Homo sapiens_hsa006700.96063926
62Antigen processing and presentation_Homo sapiens_hsa046120.95741569
63Apoptosis_Homo sapiens_hsa042100.95222511
64Non-homologous end-joining_Homo sapiens_hsa034500.92462258
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.92245319
66Toxoplasmosis_Homo sapiens_hsa051450.88349884
67Homologous recombination_Homo sapiens_hsa034400.86800226
68Chronic myeloid leukemia_Homo sapiens_hsa052200.86451140
69Hepatitis B_Homo sapiens_hsa051610.84599745
70Arginine and proline metabolism_Homo sapiens_hsa003300.83748251
71Ether lipid metabolism_Homo sapiens_hsa005650.83613601
72Small cell lung cancer_Homo sapiens_hsa052220.82995923
73Phototransduction_Homo sapiens_hsa047440.81620563
74Viral carcinogenesis_Homo sapiens_hsa052030.81563045
75Influenza A_Homo sapiens_hsa051640.81156984
76Hepatitis C_Homo sapiens_hsa051600.80693304
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79688549
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78581558
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.77600537
80Alcoholism_Homo sapiens_hsa050340.77409537
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74843073
82Staphylococcus aureus infection_Homo sapiens_hsa051500.73879712
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73449976
84Glycerolipid metabolism_Homo sapiens_hsa005610.72170598
85Non-small cell lung cancer_Homo sapiens_hsa052230.71045964
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.70731838
87Osteoclast differentiation_Homo sapiens_hsa043800.70211180
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69668928
89Peroxisome_Homo sapiens_hsa041460.69001940
90Pyruvate metabolism_Homo sapiens_hsa006200.66340696
91Sulfur metabolism_Homo sapiens_hsa009200.66236513
92Metabolic pathways_Homo sapiens_hsa011000.66036066
93Complement and coagulation cascades_Homo sapiens_hsa046100.66008322
94Fatty acid elongation_Homo sapiens_hsa000620.64954030
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.64546061
96Protein export_Homo sapiens_hsa030600.63300743
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59493368
98Steroid biosynthesis_Homo sapiens_hsa001000.59434861
99Oxidative phosphorylation_Homo sapiens_hsa001900.58643452
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57713858
101Chemical carcinogenesis_Homo sapiens_hsa052040.57586885
102Purine metabolism_Homo sapiens_hsa002300.56790108
103HTLV-I infection_Homo sapiens_hsa051660.56039156
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55604214
105Pentose phosphate pathway_Homo sapiens_hsa000300.54638430
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53090256
107RNA polymerase_Homo sapiens_hsa030200.53019525
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52726578
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52380017
110Glutathione metabolism_Homo sapiens_hsa004800.51303229
111RNA transport_Homo sapiens_hsa030130.50198905
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.50186134
113Vitamin B6 metabolism_Homo sapiens_hsa007500.49654377
114Legionellosis_Homo sapiens_hsa051340.46922651
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46905710
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46829312
117Lysine degradation_Homo sapiens_hsa003100.46108972
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.45842110
119Prolactin signaling pathway_Homo sapiens_hsa049170.45768334
120beta-Alanine metabolism_Homo sapiens_hsa004100.45202806
121Insulin resistance_Homo sapiens_hsa049310.43547656
122Propanoate metabolism_Homo sapiens_hsa006400.42888199
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42104905
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.41717420
125Pancreatic cancer_Homo sapiens_hsa052120.41508916
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39316000
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38930940
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38783329
129Mineral absorption_Homo sapiens_hsa049780.38507915
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37409913
131T cell receptor signaling pathway_Homo sapiens_hsa046600.36969013
132Vitamin digestion and absorption_Homo sapiens_hsa049770.35527439
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34809934
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34486252
135TNF signaling pathway_Homo sapiens_hsa046680.34188044
136Fructose and mannose metabolism_Homo sapiens_hsa000510.32961664
137Fatty acid biosynthesis_Homo sapiens_hsa000610.32063547
138Tryptophan metabolism_Homo sapiens_hsa003800.32046856
139PPAR signaling pathway_Homo sapiens_hsa033200.31959495
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31833957
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31821602
142Asthma_Homo sapiens_hsa053100.30613897
143Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30429770
144Serotonergic synapse_Homo sapiens_hsa047260.29363367
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28782606
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.28568935
147Ovarian steroidogenesis_Homo sapiens_hsa049130.28463328
148Basal transcription factors_Homo sapiens_hsa030220.28048372
149Parkinsons disease_Homo sapiens_hsa050120.27625198
150Fanconi anemia pathway_Homo sapiens_hsa034600.22102159
151Regulation of autophagy_Homo sapiens_hsa041400.16305528
152Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14962425
153Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14190461
154Circadian rhythm_Homo sapiens_hsa047100.13952609
155Glycosaminoglycan degradation_Homo sapiens_hsa005310.10327621
156Taste transduction_Homo sapiens_hsa047420.09931184
157Proteasome_Homo sapiens_hsa030500.08948478
158Nicotine addiction_Homo sapiens_hsa050330.08496880
159Olfactory transduction_Homo sapiens_hsa047400.07843179
160Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.07592997
161Collecting duct acid secretion_Homo sapiens_hsa049660.07339824
162Carbon metabolism_Homo sapiens_hsa012000.02673614

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