ART5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the ARG-specific ADP-ribosyltransferase family. Proteins in this family regulate the function of target proteins by attaching ADP-ribose to specific amino acid residues in their target proteins. The mouse homolog lacks a glycosylphosphatidylinositol-anchor signal sequence and is predicted to be a secretory enzyme. Several transcripts encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)7.81778711
2fusion of sperm to egg plasma membrane (GO:0007342)7.69307295
3cell wall macromolecule catabolic process (GO:0016998)7.66058810
4cell wall macromolecule metabolic process (GO:0044036)7.66058810
5muscle filament sliding (GO:0030049)7.57059363
6actin-myosin filament sliding (GO:0033275)7.57059363
7sperm-egg recognition (GO:0035036)6.99929198
8acrosome reaction (GO:0007340)6.96346449
9acrosome assembly (GO:0001675)6.51996406
10binding of sperm to zona pellucida (GO:0007339)6.47877389
11regulation of skeletal muscle contraction (GO:0014819)6.29529496
12cilium or flagellum-dependent cell motility (GO:0001539)6.26364108
13motile cilium assembly (GO:0044458)6.22597163
14cell-cell recognition (GO:0009988)6.21705656
15sarcomere organization (GO:0045214)6.19028635
16actin-mediated cell contraction (GO:0070252)6.10822477
17plasma membrane fusion (GO:0045026)6.02904490
18spermatid development (GO:0007286)6.02768593
19multicellular organism reproduction (GO:0032504)5.96783008
20axonemal dynein complex assembly (GO:0070286)5.90889676
21sarcoplasmic reticulum calcium ion transport (GO:0070296)5.60261947
22negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.53573889
23skeletal muscle contraction (GO:0003009)5.42638891
24piRNA metabolic process (GO:0034587)5.37418809
25epithelial cilium movement (GO:0003351)5.36740430
26plasma membrane repair (GO:0001778)5.34216480
27myofibril assembly (GO:0030239)5.33560818
28synaptonemal complex organization (GO:0070193)5.31993944
29reproduction (GO:0000003)5.04964312
30regulation of cilium movement (GO:0003352)5.01313788
31tricarboxylic acid cycle (GO:0006099)4.99683001
32synaptonemal complex assembly (GO:0007130)4.96773345
33cardiac myofibril assembly (GO:0055003)4.96517234
34carnitine transmembrane transport (GO:1902603)4.88720051
35negative regulation of inclusion body assembly (GO:0090084)4.83519619
36male meiosis (GO:0007140)4.81876500
37negative regulation of potassium ion transmembrane transport (GO:1901380)4.69808451
38carnitine shuttle (GO:0006853)4.68832598
39amino-acid betaine transport (GO:0015838)4.66762260
40carnitine transport (GO:0015879)4.66762260
41positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.59305887
42striated muscle contraction (GO:0006941)4.56889250
43sperm capacitation (GO:0048240)4.55407535
44actin filament-based movement (GO:0030048)4.42616837
45regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.32623490
46cilium movement (GO:0003341)4.24934983
47chromatin remodeling at centromere (GO:0031055)4.23547698
48cardiac muscle cell development (GO:0055013)4.17444054
49cardiac muscle contraction (GO:0060048)4.16306475
50CENP-A containing nucleosome assembly (GO:0034080)4.13358418
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.09334336
52spermatogenesis (GO:0007283)4.08380634
53heart contraction (GO:0060047)4.07381970
54heart process (GO:0003015)4.07381970
55male gamete generation (GO:0048232)4.06932837
56regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.05047657
57skeletal muscle adaptation (GO:0043501)4.01755760
58single fertilization (GO:0007338)4.01675521
59regulation of inclusion body assembly (GO:0090083)3.98589042
60establishment of integrated proviral latency (GO:0075713)3.94113447
61response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.93772655
62microtubule depolymerization (GO:0007019)3.93708987
63cardiac cell development (GO:0055006)3.87993047
64fatty acid transmembrane transport (GO:1902001)3.86552610
65regulation of acyl-CoA biosynthetic process (GO:0050812)3.85598185
66regulation of relaxation of muscle (GO:1901077)3.81806733
67actomyosin structure organization (GO:0031032)3.80975518
68L-serine metabolic process (GO:0006563)3.79112674
69mitotic metaphase plate congression (GO:0007080)3.75514686
70gamete generation (GO:0007276)3.70389636
71protein localization to kinetochore (GO:0034501)3.66209299
72regulation of gene silencing by miRNA (GO:0060964)3.63624444
73regulation of gene silencing by RNA (GO:0060966)3.63624444
74regulation of posttranscriptional gene silencing (GO:0060147)3.63624444
75organic cation transport (GO:0015695)3.57259263
76DNA replication checkpoint (GO:0000076)3.55634907
77IMP metabolic process (GO:0046040)3.55359106
78IMP biosynthetic process (GO:0006188)3.54640242
79fertilization (GO:0009566)3.52864265
80regulation of mitochondrial translation (GO:0070129)3.51976656
81chromosome condensation (GO:0030261)3.51359702
82histone exchange (GO:0043486)3.50277308
83regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.49630936
84outer ear morphogenesis (GO:0042473)3.48982925
85regulation of coenzyme metabolic process (GO:0051196)3.48766339
86regulation of cofactor metabolic process (GO:0051193)3.48766339
87anterior/posterior axis specification, embryo (GO:0008595)3.48591815
88DNA methylation involved in gamete generation (GO:0043046)3.48082757
89pyrimidine ribonucleoside catabolic process (GO:0046133)3.47884339
90glycolytic process (GO:0006096)3.45901577
91DNA packaging (GO:0006323)3.43830494
92ventricular cardiac muscle cell development (GO:0055015)3.43207528
93male meiosis I (GO:0007141)3.41455302
94heterochromatin organization (GO:0070828)3.41116324
95seminiferous tubule development (GO:0072520)3.39634919
96DNA replication-independent nucleosome assembly (GO:0006336)3.36957774
97DNA replication-independent nucleosome organization (GO:0034724)3.36957774
98muscle contraction (GO:0006936)3.36847943
99negative regulation of skeletal muscle tissue development (GO:0048642)3.33458402
100cellular process involved in reproduction in multicellular organism (GO:0022412)3.32371420
101regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.30981979
102creatine metabolic process (GO:0006600)3.30647117
103germ cell development (GO:0007281)3.30305942
104regulation of cell communication by electrical coupling (GO:0010649)3.30084934
105response to inactivity (GO:0014854)3.27313039
106left/right pattern formation (GO:0060972)3.26968416
107DNA strand elongation involved in DNA replication (GO:0006271)3.25855913
108negative regulation of chromosome segregation (GO:0051985)3.25669885
109paraxial mesoderm development (GO:0048339)3.24989787
110protein complex localization (GO:0031503)3.24374333
111meiotic nuclear division (GO:0007126)3.22870471
112DNA replication-dependent nucleosome assembly (GO:0006335)3.22496667
113DNA replication-dependent nucleosome organization (GO:0034723)3.22496667
114protein localization to chromosome, centromeric region (GO:0071459)3.21415491
115quaternary ammonium group transport (GO:0015697)3.20687413
116regulation of actin filament-based movement (GO:1903115)3.17382022
117negative regulation of mitotic sister chromatid separation (GO:2000816)3.16924471
118negative regulation of sister chromatid segregation (GO:0033046)3.16924471
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.16924471
120negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.16924471
121negative regulation of mitotic sister chromatid segregation (GO:0033048)3.16924471
122proteasome assembly (GO:0043248)3.14262647
123oxidative phosphorylation (GO:0006119)3.13832747
124heart trabecula formation (GO:0060347)3.12191176
125chromosome organization involved in meiosis (GO:0070192)3.12086260
126DNA strand elongation (GO:0022616)3.09308706
127metaphase plate congression (GO:0051310)3.08662904
128establishment of protein localization to mitochondrial membrane (GO:0090151)3.08498340
129cardiac muscle tissue morphogenesis (GO:0055008)3.07962492
130ribosomal small subunit assembly (GO:0000028)3.04679403
131spindle checkpoint (GO:0031577)3.04353671
132positive regulation of SMAD protein import into nucleus (GO:0060391)3.03087961
133muscle system process (GO:0003012)3.00499021
134chaperone-mediated protein transport (GO:0072321)2.99821656
135purine nucleobase biosynthetic process (GO:0009113)2.98799262
136mitotic spindle checkpoint (GO:0071174)2.98630437
137cardiac muscle hypertrophy (GO:0003300)2.95576666
138mitotic chromosome condensation (GO:0007076)2.94453143
139nucleobase biosynthetic process (GO:0046112)2.94114077
140muscle tissue morphogenesis (GO:0060415)2.92929504
141mitotic sister chromatid segregation (GO:0000070)2.92058494
142mitotic spindle assembly checkpoint (GO:0007094)2.91860139
143regulation of sulfur metabolic process (GO:0042762)2.90976005
144striated muscle hypertrophy (GO:0014897)2.90669660
145adult heart development (GO:0007512)2.89665597
146glycerol ether metabolic process (GO:0006662)2.89258536
147negative regulation of mitosis (GO:0045839)2.88241713
148primitive streak formation (GO:0090009)2.87940960
149DNA damage response, detection of DNA damage (GO:0042769)2.87636997
150positive regulation of chromosome segregation (GO:0051984)2.87540020
151DNA ligation (GO:0006266)2.87446791
152establishment of viral latency (GO:0019043)2.87073053
153spindle assembly checkpoint (GO:0071173)2.87055866
154regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.86766024
155regulation of mitotic metaphase/anaphase transition (GO:0030071)2.86766024
156DNA unwinding involved in DNA replication (GO:0006268)2.84547689
157regulation of chromosome segregation (GO:0051983)2.82474262
158pre-miRNA processing (GO:0031054)2.82407588
159regulation of mitotic sister chromatid separation (GO:0010965)2.78816673
160regulation of mitotic sister chromatid segregation (GO:0033047)2.78816673
161regulation of sister chromatid segregation (GO:0033045)2.78816673
162regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.78380551
163regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74609256
164regulation of mitotic spindle checkpoint (GO:1903504)2.74609256
165formation of translation preinitiation complex (GO:0001731)2.73576363
166DNA replication initiation (GO:0006270)2.73507120
167DNA strand renaturation (GO:0000733)2.73222144
168somite rostral/caudal axis specification (GO:0032525)2.72603806
169histone arginine methylation (GO:0034969)2.71848704
170regulation of helicase activity (GO:0051095)2.71796645
171telomere maintenance via semi-conservative replication (GO:0032201)2.71778929
172kinetochore assembly (GO:0051382)2.68729792
173protein neddylation (GO:0045116)2.68028818
174sister chromatid segregation (GO:0000819)2.67799654
175cullin deneddylation (GO:0010388)2.66596603
176kinetochore organization (GO:0051383)2.64639147
177muscle cell fate commitment (GO:0042693)2.64462457
178negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.62839891
179serine family amino acid biosynthetic process (GO:0009070)2.62350449
180anterior/posterior axis specification (GO:0009948)2.62280111
181ATP-dependent chromatin remodeling (GO:0043044)2.62077728
182regulation of nuclear cell cycle DNA replication (GO:0033262)2.61479056
183negative regulation of cell fate specification (GO:0009996)2.58934149
184nuclear pore complex assembly (GO:0051292)2.57946988
185somatic diversification of immune receptors via somatic mutation (GO:0002566)2.57868413
186somatic hypermutation of immunoglobulin genes (GO:0016446)2.57868413
187regulation of cell fate specification (GO:0042659)2.57838746
188negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.57340608
189regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.56713357
190lysine catabolic process (GO:0006554)2.56023325
191lysine metabolic process (GO:0006553)2.56023325
192nuclear pore organization (GO:0006999)2.55964647
193anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.55379736
194establishment of chromosome localization (GO:0051303)2.53501223
195cellular protein complex localization (GO:0034629)2.52176173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.72459279
2E2F7_22180533_ChIP-Seq_HELA_Human5.81876468
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.11193790
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59982770
5EZH2_22144423_ChIP-Seq_EOC_Human3.55355005
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.49739043
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27181594
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03313019
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94934548
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.94744790
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.84195650
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.84195650
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.84195650
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.80828323
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78943949
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.74742469
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65494762
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61626250
19TBX20_22080862_ChIP-Seq_HEART_Mouse2.59920592
20TBX20_22328084_ChIP-Seq_HEART_Mouse2.59920592
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.58082256
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57068439
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.50810259
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.50768688
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.44951278
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44357109
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.43477434
28AR_21909140_ChIP-Seq_LNCAP_Human2.38750821
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37986625
30GABP_17652178_ChIP-ChIP_JURKAT_Human2.36180753
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.34094318
32VDR_22108803_ChIP-Seq_LS180_Human2.33866500
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33608676
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27153050
35ETS1_20019798_ChIP-Seq_JURKAT_Human2.19003419
36ZNF274_21170338_ChIP-Seq_K562_Hela2.17545274
37E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16497154
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15479596
39CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.11612280
40ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.10383320
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04306939
42YY1_22570637_ChIP-Seq_MALME-3M_Human2.00067499
43ZNF263_19887448_ChIP-Seq_K562_Human1.97436462
44XRN2_22483619_ChIP-Seq_HELA_Human1.97338303
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.96826064
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94846344
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.94588526
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.88263675
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88211167
50TTF2_22483619_ChIP-Seq_HELA_Human1.88195712
51NANOG_16153702_ChIP-ChIP_HESCs_Human1.88096451
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87885555
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84506046
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.79710533
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76659708
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.76121177
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75469322
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.74235647
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.72495950
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68508167
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.66493362
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.65914422
63PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.65779505
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65530272
65MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.62321579
66DCP1A_22483619_ChIP-Seq_HELA_Human1.61901484
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61379534
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.60113953
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.59551953
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59131190
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.57150090
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.54993148
73NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.54841901
74FOXP3_21729870_ChIP-Seq_TREG_Human1.54506502
75FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53455755
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53408778
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52879277
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52428512
79BCOR_27268052_Chip-Seq_Bcells_Human1.51951212
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50376982
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.48373081
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.46926572
83SOX2_22085726_ChIP-Seq_NPCs_Mouse1.45011903
84GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44678569
85WDR5_24793694_ChIP-Seq_LNCAP_Human1.44659133
86GATA3_21867929_ChIP-Seq_CD8_Mouse1.43887284
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41429644
88CTCF_27219007_Chip-Seq_Bcells_Human1.38621694
89GABP_19822575_ChIP-Seq_HepG2_Human1.37387380
90ELK4_26923725_Chip-Seq_MESODERM_Mouse1.34550984
91LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.34388176
92SMC3_22415368_ChIP-Seq_MEFs_Mouse1.34263716
93TET1_21451524_ChIP-Seq_MESCs_Mouse1.33626448
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33587542
95BCL6_27268052_Chip-Seq_Bcells_Human1.32767311
96CTCF_26484167_Chip-Seq_Bcells_Mouse1.31578616
97ELK1_19687146_ChIP-ChIP_HELA_Human1.31224690
98E2F1_20622854_ChIP-Seq_HELA_Human1.30391990
99PHF8_20622854_ChIP-Seq_HELA_Human1.30041711
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29928322
101P53_21459846_ChIP-Seq_SAOS-2_Human1.28357558
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27996980
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26938774
104SPI1_20517297_ChIP-Seq_HL60_Human1.26658200
105FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26053212
106VDR_23849224_ChIP-Seq_CD4+_Human1.25975764
107MYC_27129775_Chip-Seq_CORNEA_Mouse1.24393851
108TCF3_18692474_ChIP-Seq_MESCs_Mouse1.23292390
109ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21947282
110NANOG_20526341_ChIP-Seq_ESCs_Human1.21105853
111MYC_18940864_ChIP-ChIP_HL60_Human1.21076731
112CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21007708
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20503885
114STAT1_20625510_ChIP-Seq_HELA_Human1.20268687
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19785507
116RAC3_21632823_ChIP-Seq_H3396_Human1.18819461
117STAT1_17558387_ChIP-Seq_HELA_Human1.17343813
118P68_20966046_ChIP-Seq_HELA_Human1.16890005
119SRF_21415370_ChIP-Seq_HL-1_Mouse1.16696477
120CBP_20019798_ChIP-Seq_JUKART_Human1.16671999
121IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16671999
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.16656386
123* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16012934
124FLI1_27457419_Chip-Seq_LIVER_Mouse1.15158781
125PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14872682
126KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14169616
127TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14020154
128SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13127597
129OCT4_20526341_ChIP-Seq_ESCs_Human1.12032432
130TP63_22573176_ChIP-Seq_HFKS_Human1.11336217
131ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10180157
132RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10118716
133RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08206871
134ERG_20517297_ChIP-Seq_VCAP_Human1.07976588
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07809710
136GATA1_19941827_ChIP-Seq_MEL86_Mouse1.07205178
137SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05685947
138RAD21_21589869_ChIP-Seq_MESCs_Mouse1.05440562
139FOXM1_23109430_ChIP-Seq_U2OS_Human1.05140353
140TP63_19390658_ChIP-ChIP_HaCaT_Human1.04833845
141SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04440141
142SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02397443
143HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02316015
144PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02246273
145PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02156969
146CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01856967
147ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00154973
148SOX17_20123909_ChIP-Seq_XEN_Mouse1.00003188
149EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99642122
150SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99640945
151RARA_24833708_ChIP-Seq_LIVER_Mouse0.99571969
152NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99003168
153FOXH1_21741376_ChIP-Seq_ESCs_Human0.98785485
154E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97707949
155SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.97618027
156EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96455655
157GATA1_26923725_Chip-Seq_HPCs_Mouse0.96180869
158CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95870789
159NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95235013
160PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94979026
161TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.94821613
162BP1_19119308_ChIP-ChIP_Hs578T_Human0.94568328
163NANOG_21062744_ChIP-ChIP_HESCs_Human0.94524865
164SPI1_26923725_Chip-Seq_HPCs_Mouse0.93437186
165NANOG_18692474_ChIP-Seq_MEFs_Mouse0.92375716
166AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90842127
167CSB_26484114_Chip-Seq_FIBROBLAST_Human0.90775482
168SMC4_20622854_ChIP-Seq_HELA_Human0.90519389
169CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89810829
170MYC_19829295_ChIP-Seq_ESCs_Human0.89639035
171OCT4_19829295_ChIP-Seq_ESCs_Human0.89483435
172PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89348891
173* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89012864
174SOX11_22085726_ChIP-Seq_ESNs_Mouse0.88898835
175KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88331207
176SOX2_21211035_ChIP-Seq_LN229_Human0.87852243
177SOX2_18692474_ChIP-Seq_MESCs_Mouse0.87705181
178SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.87323591
179LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86199424
180* SA1_27219007_Chip-Seq_Bcells_Human0.86123349
181GF1_26923725_Chip-Seq_HPCs_Mouse0.86081760
182P300_27268052_Chip-Seq_Bcells_Human0.85667613
183SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85571167
184ESET_19884257_ChIP-Seq_ESCs_Mouse0.85552103
185HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85223508
186GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84910023
187* CTCF_20526341_ChIP-Seq_ESCs_Human0.84891885
188* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.82782345
189* EOMES_21245162_ChIP-Seq_HESCs_Human0.81492518
190SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.79199135

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.70207984
2MP0003646_muscle_fatigue6.21884095
3MP0000751_myopathy4.94934431
4MP0000749_muscle_degeneration4.72097476
5MP0002837_dystrophic_cardiac_calcinosis4.36116545
6MP0004145_abnormal_muscle_electrophysio4.33540409
7MP0004036_abnormal_muscle_relaxation3.85011601
8MP0004084_abnormal_cardiac_muscle3.65081543
9MP0003693_abnormal_embryo_hatching3.53973038
10MP0010030_abnormal_orbit_morphology3.31140782
11MP0002106_abnormal_muscle_physiology3.11752567
12MP0004957_abnormal_blastocyst_morpholog3.04254669
13MP0002269_muscular_atrophy2.98549404
14MP0004087_abnormal_muscle_fiber2.98048808
15MP0004215_abnormal_myocardial_fiber2.83545340
16MP0000750_abnormal_muscle_regeneration2.83223510
17MP0003890_abnormal_embryonic-extraembry2.79315214
18MP0008932_abnormal_embryonic_tissue2.72114045
19MP0004233_abnormal_muscle_weight2.70441036
20MP0000759_abnormal_skeletal_muscle2.68679185
21MP0000747_muscle_weakness2.63436383
22MP0005330_cardiomyopathy2.62121761
23MP0004130_abnormal_muscle_cell2.53741541
24MP0003698_abnormal_male_reproductive2.50514453
25MP0005620_abnormal_muscle_contractility2.49670958
26MP0005369_muscle_phenotype2.48741748
27MP0001929_abnormal_gametogenesis2.31550611
28MP0003718_maternal_effect2.25551880
29MP0003077_abnormal_cell_cycle2.21376794
30MP0002254_reproductive_system_inflammat2.20064903
31MP0008877_abnormal_DNA_methylation2.19695763
32MP0006036_abnormal_mitochondrial_physio2.13689013
33MP0003119_abnormal_digestive_system2.02365202
34MP0006292_abnormal_olfactory_placode1.98148283
35MP0010630_abnormal_cardiac_muscle1.92247999
36MP0002972_abnormal_cardiac_muscle1.91269104
37MP0001293_anophthalmia1.86355393
38MP0005670_abnormal_white_adipose1.78894137
39MP0005385_cardiovascular_system_phenoty1.76299983
40MP0001544_abnormal_cardiovascular_syste1.76299983
41MP0003950_abnormal_plasma_membrane1.74604596
42MP0004484_altered_response_of1.73426626
43MP0006138_congestive_heart_failure1.68124852
44MP0003937_abnormal_limbs/digits/tail_de1.64939469
45MP0000049_abnormal_middle_ear1.56743690
46MP0005666_abnormal_adipose_tissue1.50823941
47MP0003137_abnormal_impulse_conducting1.48072846
48MP0003221_abnormal_cardiomyocyte_apopto1.45711318
49MP0002697_abnormal_eye_size1.45325078
50MP0002210_abnormal_sex_determination1.43664224
51MP0002085_abnormal_embryonic_tissue1.42003854
52MP0002084_abnormal_developmental_patter1.40111377
53MP0002234_abnormal_pharynx_morphology1.39574364
54MP0000733_abnormal_muscle_development1.38718489
55MP0008057_abnormal_DNA_replication1.35409106
56MP0002332_abnormal_exercise_endurance1.32484875
57MP0008775_abnormal_heart_ventricle1.30542966
58MP0002161_abnormal_fertility/fecundity1.27132086
59MP0000350_abnormal_cell_proliferation1.25654655
60MP0002233_abnormal_nose_morphology1.23541072
61MP0008789_abnormal_olfactory_epithelium1.21406296
62MP0000372_irregular_coat_pigmentation1.18730917
63MP0002127_abnormal_cardiovascular_syste1.18363228
64MP0000428_abnormal_craniofacial_morphol1.17860840
65MP0002108_abnormal_muscle_morphology1.16200469
66MP0003385_abnormal_body_wall1.12168684
67MP0001145_abnormal_male_reproductive1.11479405
68MP0009697_abnormal_copulation1.10262370
69MP0002111_abnormal_tail_morphology1.08991907
70MP0002080_prenatal_lethality1.07820487
71MP0006035_abnormal_mitochondrial_morpho1.06327270
72MP0002938_white_spotting1.03792323
73MP0001529_abnormal_vocalization1.02590130
74MP0003828_pulmonary_edema1.01840973
75MP0002653_abnormal_ependyma_morphology0.98215914
76MP0001286_abnormal_eye_development0.97433512
77MP0004085_abnormal_heartbeat0.96691142
78MP0000653_abnormal_sex_gland0.95346096
79MP0003186_abnormal_redox_activity0.92755301
80MP0001661_extended_life_span0.88832706
81MP0000537_abnormal_urethra_morphology0.88807875
82MP0001299_abnormal_eye_distance/0.88157025
83MP0001188_hyperpigmentation0.88029057
84MP0005394_taste/olfaction_phenotype0.87497934
85MP0005499_abnormal_olfactory_system0.87497934
86MP0004272_abnormal_basement_membrane0.86969940
87MP0000266_abnormal_heart_morphology0.85650002
88MP0005266_abnormal_metabolism0.85242711
89MP0002971_abnormal_brown_adipose0.84112685
90MP0009703_decreased_birth_body0.83970292
91MP0003136_yellow_coat_color0.81977248
92MP0005375_adipose_tissue_phenotype0.80257477
93MP0003942_abnormal_urinary_system0.78868100
94MP0001346_abnormal_lacrimal_gland0.78588801
95MP0003861_abnormal_nervous_system0.78244581
96MP0005377_hearing/vestibular/ear_phenot0.77404777
97MP0003878_abnormal_ear_physiology0.77404777
98MP0003938_abnormal_ear_development0.76782237
99MP0002102_abnormal_ear_morphology0.76439318
100MP0002086_abnormal_extraembryonic_tissu0.75858520
101MP0000313_abnormal_cell_death0.75601901
102MP0002092_abnormal_eye_morphology0.74863374
103MP0005623_abnormal_meninges_morphology0.74604841
104MP0003806_abnormal_nucleotide_metabolis0.73900290
105MP0003755_abnormal_palate_morphology0.73094944
106MP0002114_abnormal_axial_skeleton0.73068829
107MP0003935_abnormal_craniofacial_develop0.72596768
108MP0003567_abnormal_fetal_cardiomyocyte0.71609340
109MP0004185_abnormal_adipocyte_glucose0.71272934
110MP0003941_abnormal_skin_development0.68760318
111MP0010094_abnormal_chromosome_stability0.65410436
112MP0000343_altered_response_to0.60103203
113MP0001730_embryonic_growth_arrest0.59997059
114MP0004510_myositis0.56683642
115MP0003984_embryonic_growth_retardation0.54034381
116MP0000678_abnormal_parathyroid_gland0.51679573
117MP0002088_abnormal_embryonic_growth/wei0.51418440
118MP0004147_increased_porphyrin_level0.50572374
119MP0002160_abnormal_reproductive_system0.50074113
120MP0005380_embryogenesis_phenotype0.47381295
121MP0001672_abnormal_embryogenesis/_devel0.47381295
122MP0000566_synostosis0.45784851
123MP0002128_abnormal_blood_circulation0.45668542
124MP0004043_abnormal_pH_regulation0.45092153
125MP0008961_abnormal_basal_metabolism0.44687948
126MP0000358_abnormal_cell_content/0.44165394
127MP0000762_abnormal_tongue_morphology0.42049817
128MP0000534_abnormal_ureter_morphology0.41494565
129MP0009250_abnormal_appendicular_skeleto0.38327457
130MP0004808_abnormal_hematopoietic_stem0.38296680
131MP0005187_abnormal_penis_morphology0.38063302
132MP0001697_abnormal_embryo_size0.35420724
133MP0002925_abnormal_cardiovascular_devel0.35161117
134MP0003948_abnormal_gas_homeostasis0.34382946
135MP0002249_abnormal_larynx_morphology0.33512091
136MP0003111_abnormal_nucleus_morphology0.32429699
137MP0008058_abnormal_DNA_repair0.31922915
138MP0008007_abnormal_cellular_replicative0.30154346
139MP0005319_abnormal_enzyme/_coenzyme0.29745550
140MP0004133_heterotaxia0.29481430
141MP0009115_abnormal_fat_cell0.29324014
142MP0004197_abnormal_fetal_growth/weight/0.29256829
143MP0001849_ear_inflammation0.29210510
144MP0005334_abnormal_fat_pad0.27518701
145MP0002078_abnormal_glucose_homeostasis0.27166202
146MP0005165_increased_susceptibility_to0.25374933
147MP0009672_abnormal_birth_weight0.24688846
148MP0005171_absent_coat_pigmentation0.24267266
149MP0001784_abnormal_fluid_regulation0.23879259

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)7.57108930
2Exercise-induced muscle cramps (HP:0003710)7.07922015
3Muscle fiber inclusion bodies (HP:0100299)6.86056351
4Muscle hypertrophy of the lower extremities (HP:0008968)6.51977062
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.47811173
6Calf muscle hypertrophy (HP:0008981)6.43743836
7Nemaline bodies (HP:0003798)5.98633533
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.72238710
9Absent/shortened dynein arms (HP:0200106)5.46644526
10Dynein arm defect of respiratory motile cilia (HP:0012255)5.46644526
11Myoglobinuria (HP:0002913)5.43899485
12Muscle fiber splitting (HP:0003555)5.22416673
13Hyporeflexia of lower limbs (HP:0002600)5.07064253
14Type 1 muscle fiber predominance (HP:0003803)5.06896934
15Difficulty running (HP:0009046)4.73588954
16Rhabdomyolysis (HP:0003201)4.58687823
17Sudden death (HP:0001699)4.52149212
18Abnormality of the calf musculature (HP:0001430)4.50231759
19Distal arthrogryposis (HP:0005684)4.13320657
20EMG: myopathic abnormalities (HP:0003458)4.04315503
21Difficulty climbing stairs (HP:0003551)3.95788526
22Abnormality of the left ventricular outflow tract (HP:0011103)3.90993130
23Subaortic stenosis (HP:0001682)3.90993130
24Myopathic facies (HP:0002058)3.82499771
25Ulnar deviation of the wrist (HP:0003049)3.80352920
26Abnormal respiratory motile cilium morphology (HP:0005938)3.80099619
27Abnormal respiratory epithelium morphology (HP:0012253)3.80099619
28Abnormal respiratory motile cilium physiology (HP:0012261)3.77938966
29Increased connective tissue (HP:0009025)3.76800302
30Asymmetric septal hypertrophy (HP:0001670)3.76337013
31Ventricular tachycardia (HP:0004756)3.71433753
32Muscle stiffness (HP:0003552)3.46669177
33Round ear (HP:0100830)3.29552564
34Bundle branch block (HP:0011710)3.24691044
35Myotonia (HP:0002486)3.20748753
36Rhinitis (HP:0012384)3.17332418
37Rimmed vacuoles (HP:0003805)3.13235242
38Septo-optic dysplasia (HP:0100842)3.10956160
39Lipoatrophy (HP:0100578)3.05620646
40Chronic bronchitis (HP:0004469)3.04527530
41Infertility (HP:0000789)3.00754162
42Areflexia of lower limbs (HP:0002522)2.99714498
43Hyperglycinemia (HP:0002154)2.90080640
44Nasal polyposis (HP:0100582)2.88482229
45Neck muscle weakness (HP:0000467)2.85922183
46Calcaneovalgus deformity (HP:0001848)2.85457107
47Progressive muscle weakness (HP:0003323)2.81728351
48Abnormal lung lobation (HP:0002101)2.79220407
49Atrial fibrillation (HP:0005110)2.76978535
50EMG: neuropathic changes (HP:0003445)2.76617805
51Abnormality of skeletal muscle fiber size (HP:0012084)2.75747461
52Hyperglycinuria (HP:0003108)2.74453428
53Birth length less than 3rd percentile (HP:0003561)2.70027503
54Dilated cardiomyopathy (HP:0001644)2.68786818
55Abnormal ciliary motility (HP:0012262)2.66317893
56Abnormality of the nasal mucosa (HP:0000433)2.66126426
57Generalized muscle weakness (HP:0003324)2.62281124
58Increased variability in muscle fiber diameter (HP:0003557)2.55011447
59Carpal bone hypoplasia (HP:0001498)2.54965097
60Deformed tarsal bones (HP:0008119)2.54671721
61Primary atrial arrhythmia (HP:0001692)2.53152415
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52005390
63Maternal diabetes (HP:0009800)2.49853680
64Abnormality of the neuromuscular junction (HP:0003398)2.47790698
65Fatigable weakness (HP:0003473)2.47790698
66Absent phalangeal crease (HP:0006109)2.44699650
67Abnormality of serine family amino acid metabolism (HP:0010894)2.43299289
68Abnormality of glycine metabolism (HP:0010895)2.43299289
69Supraventricular tachycardia (HP:0004755)2.42100325
70Colon cancer (HP:0003003)2.39490300
71Increased serum pyruvate (HP:0003542)2.39096682
72Palpitations (HP:0001962)2.38643647
73Chromsome breakage (HP:0040012)2.38485638
74Heart block (HP:0012722)2.37739727
75Supraventricular arrhythmia (HP:0005115)2.35088315
76Abnormal finger flexion creases (HP:0006143)2.33468822
77Bulbar palsy (HP:0001283)2.31666160
78Gowers sign (HP:0003391)2.31622647
79Abnormality of glycolysis (HP:0004366)2.28895684
80Abnormality of the fetal cardiovascular system (HP:0010948)2.28234306
81Abnormal umbilical cord blood vessels (HP:0011403)2.28234306
82Single umbilical artery (HP:0001195)2.28234306
83Reticulocytopenia (HP:0001896)2.28116049
84Meckel diverticulum (HP:0002245)2.27279732
85Abnormal ventriculo-arterial connection (HP:0011563)2.27244686
86Transposition of the great arteries (HP:0001669)2.27244686
87Abnormal connection of the cardiac segments (HP:0011545)2.27244686
88Pancreatic islet-cell hyperplasia (HP:0004510)2.23468118
89Bifid tongue (HP:0010297)2.21421929
90Distal lower limb muscle weakness (HP:0009053)2.21408060
91Aplasia/Hypoplasia of the sacrum (HP:0008517)2.20447806
92Abnormal atrioventricular conduction (HP:0005150)2.19943421
93Absent septum pellucidum (HP:0001331)2.19793674
94Muscular dystrophy (HP:0003560)2.19075806
95Weak cry (HP:0001612)2.18197506
96Abnormality of the ileum (HP:0001549)2.16187975
97Partial duplication of thumb phalanx (HP:0009944)2.15814230
98Absent radius (HP:0003974)2.15799872
99Right ventricular cardiomyopathy (HP:0011663)2.13682799
100Abnormality of the labia minora (HP:0012880)2.11544471
101Preauricular pit (HP:0004467)2.10157900
102Periauricular skin pits (HP:0100277)2.10157900
103Hyperkalemia (HP:0002153)2.08582279
104Multiple enchondromatosis (HP:0005701)2.07206591
105Bilateral microphthalmos (HP:0007633)2.06273116
106Abnormality of the umbilical cord (HP:0010881)2.05367539
107Proximal amyotrophy (HP:0007126)2.05282628
108Partial duplication of the phalanx of hand (HP:0009999)2.03206339
109Rectovaginal fistula (HP:0000143)2.02584886
110Rectal fistula (HP:0100590)2.02584886
111Short middle phalanx of the 5th finger (HP:0004220)2.02562724
112Ventricular arrhythmia (HP:0004308)2.02374730
113Easy fatigability (HP:0003388)2.02324048
114Centrally nucleated skeletal muscle fibers (HP:0003687)2.01804134
115Malignant hyperthermia (HP:0002047)2.01638948
116Spastic diplegia (HP:0001264)1.99131214
117Absent forearm bone (HP:0003953)1.98811220
118Aplasia involving forearm bones (HP:0009822)1.98811220
119Nephroblastoma (Wilms tumor) (HP:0002667)1.98018704
120Embryonal renal neoplasm (HP:0011794)1.97857567
121Left ventricular hypertrophy (HP:0001712)1.97502517
122Gonadotropin excess (HP:0000837)1.96917252
123Prolonged QT interval (HP:0001657)1.96707361
124Duplication of thumb phalanx (HP:0009942)1.96617923
125Mildly elevated creatine phosphokinase (HP:0008180)1.96204826
126Abnormality of the septum pellucidum (HP:0007375)1.95622947
127Frequent falls (HP:0002359)1.95015673
128Acute necrotizing encephalopathy (HP:0006965)1.94799956
129Abnormality of serum amino acid levels (HP:0003112)1.93732355
130Shoulder girdle muscle weakness (HP:0003547)1.92986529
131Syncope (HP:0001279)1.92922138
132Limb-girdle muscle weakness (HP:0003325)1.91335426
133Facial diplegia (HP:0001349)1.90930683
134Abnormal mitochondria in muscle tissue (HP:0008316)1.89419111
135Choanal stenosis (HP:0000452)1.89391640
136Exercise intolerance (HP:0003546)1.88996289
137Pelvic girdle muscle weakness (HP:0003749)1.88686540
138Aplasia/Hypoplasia of the uvula (HP:0010293)1.87566238
139Abnormality of the musculature of the pelvis (HP:0001469)1.87335585
140Abnormality of the hip-girdle musculature (HP:0001445)1.87335585
141Triphalangeal thumb (HP:0001199)1.86001510
142Ependymoma (HP:0002888)1.85494456
143Vaginal fistula (HP:0004320)1.84796714
144Abdominal situs inversus (HP:0003363)1.84371489
145Abnormality of abdominal situs (HP:0011620)1.84371489
146Atrioventricular block (HP:0001678)1.82688968
147Scapular winging (HP:0003691)1.82155026
148Hypoplastic left heart (HP:0004383)1.81187570
149Supernumerary spleens (HP:0009799)1.78958725
150Ectopic kidney (HP:0000086)1.77765037
151Male infertility (HP:0003251)1.74795105
152Cortical dysplasia (HP:0002539)1.74620887
153Preaxial foot polydactyly (HP:0001841)1.74191730
154Long clavicles (HP:0000890)1.73518041
155Limb-girdle muscle atrophy (HP:0003797)1.73274387
156Horseshoe kidney (HP:0000085)1.71281752
157Double outlet right ventricle (HP:0001719)1.69778690
158Congenital malformation of the right heart (HP:0011723)1.69778690
159Bronchitis (HP:0012387)1.69487371
160Abnormality of the calcaneus (HP:0008364)1.67833253
161Abnormality of chromosome stability (HP:0003220)1.67499080
162Acute encephalopathy (HP:0006846)1.65997716
163Myelomeningocele (HP:0002475)1.64997339
164Selective tooth agenesis (HP:0001592)1.64740470
165Stenosis of the external auditory canal (HP:0000402)1.63933670
166Intestinal fistula (HP:0100819)1.61993724
167Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.61544270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.35264748
2PDK46.35264748
3OBSCN6.09052805
4TTN5.35425036
5PDK23.93523868
6PBK3.33237649
7PHKG23.19391707
8PHKG13.19391707
9TESK13.09747793
10VRK22.84130758
11STK162.80890786
12PRKD32.57231652
13ICK2.56495090
14PINK12.28045510
15TSSK62.15023261
16SRPK12.04772628
17PLK31.99309438
18TNIK1.81352767
19MUSK1.72103409
20NUAK11.67866343
21NEK11.67642795
22MKNK11.63933035
23TAF11.62744509
24MKNK21.60856379
25TRIB31.51203389
26NME11.50318125
27MAP2K31.49989087
28PIK3CG1.49783303
29CDK191.47916797
30ERBB41.45439456
31WNK31.38105498
32PKN21.29949840
33DMPK1.29680092
34EIF2AK31.29574674
35LMTK21.28640665
36MAP3K91.27253736
37BCKDK1.26312694
38NEK21.21850632
39PTK2B1.20231343
40VRK11.19857728
41TRIM281.18449181
42SMG11.14960525
43MYLK1.10638529
44STK381.04340897
45WNK41.02904250
46KDR1.01967074
47AURKB1.00679938
48LATS21.00114267
49ACVR1B0.97837582
50ARAF0.95003661
51BRAF0.93897040
52PIK3CA0.92002551
53MAPKAPK30.90757737
54MAP2K60.89166301
55EEF2K0.88358001
56FGFR10.87288791
57MAP3K70.82654778
58STK390.81312926
59BRSK10.81191796
60DYRK1B0.80239990
61CDK70.78212933
62STK38L0.76096765
63BMPR1B0.75525708
64BUB10.73773178
65BRD40.72423066
66PRKAA10.71383128
67ZAK0.69893970
68STK30.68688595
69DYRK20.67421356
70MAPK120.67020439
71MST1R0.65855284
72PDK10.65498832
73STK240.63806305
74LATS10.63800991
75RPS6KA40.63514642
76MAP3K80.62851965
77TIE10.59887399
78MAP3K30.59663899
79MAP3K50.55990677
80CSNK1G10.55765899
81WNK10.54926024
82NEK90.53417642
83MAP3K100.52253996
84CDK10.52223328
85CCNB10.51621074
86PRKAA20.51615815
87CSNK2A10.50546478
88MST40.48402472
89CDK20.47863617
90CDK90.45161762
91WEE10.44895482
92DYRK30.44279432
93CDC70.43689540
94TAOK20.43418821
95CSNK2A20.42158601
96MELK0.41587558
97ALK0.40296283
98MTOR0.38876670
99CSNK1E0.38527108
100CDK120.37117829
101PNCK0.36972947
102NLK0.35990238
103EIF2AK20.35551202
104PRKDC0.35432086
105CDK80.35096625
106MAP4K20.34249474
107PDPK10.33861081
108TTK0.33435287
109CSNK1G30.33194493
110STK40.32722805
111NME20.32022920
112CSNK1G20.31870039
113PRKD10.31594224
114DAPK30.31425676
115ILK0.31203311
116ERBB30.31029510
117MARK30.30951538
118RPS6KA10.30514827
119CDK11A0.29999744
120STK100.29585148
121PLK20.28826658
122PRKACB0.26684752
123PKN10.26671981
124BMX0.26537952
125CAMK2D0.23762035
126PLK40.23268495
127TGFBR20.22662783
128AKT20.22322135
129CHEK20.21920971
130TGFBR10.21336228
131ROCK10.20936382
132PASK0.20872539
133CDK40.20446307
134TRPM70.18560547
135FLT30.18374231
136RPS6KC10.18344168
137RPS6KL10.18344168
138CHEK10.17445839
139EPHB10.16581971
140EPHA30.15370528
141RPS6KB20.15035774
142CAMK2G0.14784351
143ATR0.13728576
144BRSK20.12693726
145GRK70.12651509
146RPS6KA60.12327713
147RPS6KB10.12316498
148PRKG10.11630432
149PRKACA0.10469986
150ATM0.10318819
151MAP2K40.10175385
152AURKA0.09706894
153PAK40.09391121
154PLK10.07806801
155PAK10.07759995
156MAPK110.07429685

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.06772648
2Cardiac muscle contraction_Homo sapiens_hsa042604.18617659
3Propanoate metabolism_Homo sapiens_hsa006403.71082705
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.23966865
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.11092713
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.77190229
7Pyruvate metabolism_Homo sapiens_hsa006202.75949289
8Carbon metabolism_Homo sapiens_hsa012002.75760682
9Ribosome_Homo sapiens_hsa030102.74900130
10Dilated cardiomyopathy_Homo sapiens_hsa054142.72429112
11Parkinsons disease_Homo sapiens_hsa050122.63283666
12Oxidative phosphorylation_Homo sapiens_hsa001902.45063280
13Huntingtons disease_Homo sapiens_hsa050162.38265181
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.26660532
15Fatty acid degradation_Homo sapiens_hsa000712.26009515
16Non-homologous end-joining_Homo sapiens_hsa034502.20350379
17Glucagon signaling pathway_Homo sapiens_hsa049222.11643030
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.10191015
19Alzheimers disease_Homo sapiens_hsa050101.99293552
20Cell cycle_Homo sapiens_hsa041101.99117786
21RNA polymerase_Homo sapiens_hsa030201.96936655
22Fatty acid biosynthesis_Homo sapiens_hsa000611.96765685
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.94135104
24Vitamin B6 metabolism_Homo sapiens_hsa007501.76911969
25Fatty acid metabolism_Homo sapiens_hsa012121.76339239
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.67171200
27One carbon pool by folate_Homo sapiens_hsa006701.60911634
28Folate biosynthesis_Homo sapiens_hsa007901.58063139
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56256376
30Biosynthesis of amino acids_Homo sapiens_hsa012301.53654974
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.47029418
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43148962
33Fructose and mannose metabolism_Homo sapiens_hsa000511.41437742
34Starch and sucrose metabolism_Homo sapiens_hsa005001.29117788
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28859280
36Basal cell carcinoma_Homo sapiens_hsa052171.28792380
37Galactose metabolism_Homo sapiens_hsa000521.28115585
38Linoleic acid metabolism_Homo sapiens_hsa005911.26635720
39Steroid biosynthesis_Homo sapiens_hsa001001.24736930
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24540681
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.21023489
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19124564
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16430241
44Pentose phosphate pathway_Homo sapiens_hsa000301.14781413
45PPAR signaling pathway_Homo sapiens_hsa033201.14634981
46Viral myocarditis_Homo sapiens_hsa054161.09781508
47Insulin resistance_Homo sapiens_hsa049311.05587064
48Insulin signaling pathway_Homo sapiens_hsa049100.99494451
49Purine metabolism_Homo sapiens_hsa002300.96668489
50AMPK signaling pathway_Homo sapiens_hsa041520.93875799
51Hippo signaling pathway_Homo sapiens_hsa043900.88592364
52Basal transcription factors_Homo sapiens_hsa030220.87876350
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.87831263
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87799919
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.87524522
56Arginine biosynthesis_Homo sapiens_hsa002200.85532206
57RNA transport_Homo sapiens_hsa030130.84374279
58Wnt signaling pathway_Homo sapiens_hsa043100.83989522
59Protein export_Homo sapiens_hsa030600.83168069
60p53 signaling pathway_Homo sapiens_hsa041150.82288408
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80878127
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80578203
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79953789
64HIF-1 signaling pathway_Homo sapiens_hsa040660.76397584
65Calcium signaling pathway_Homo sapiens_hsa040200.74268805
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73132954
67Glycerolipid metabolism_Homo sapiens_hsa005610.72045666
68Selenocompound metabolism_Homo sapiens_hsa004500.71840539
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68153056
70TGF-beta signaling pathway_Homo sapiens_hsa043500.66976445
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.66960397
72Oxytocin signaling pathway_Homo sapiens_hsa049210.66212596
73DNA replication_Homo sapiens_hsa030300.65925997
74Tight junction_Homo sapiens_hsa045300.65802001
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64527086
76Fat digestion and absorption_Homo sapiens_hsa049750.62060193
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61899473
78Oocyte meiosis_Homo sapiens_hsa041140.61581560
79Arginine and proline metabolism_Homo sapiens_hsa003300.61256383
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57010243
81RNA degradation_Homo sapiens_hsa030180.56507943
82Dorso-ventral axis formation_Homo sapiens_hsa043200.54965621
83Thyroid cancer_Homo sapiens_hsa052160.54059977
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.53411359
85mRNA surveillance pathway_Homo sapiens_hsa030150.52041516
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51449592
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.50498326
88Metabolic pathways_Homo sapiens_hsa011000.49559765
89Homologous recombination_Homo sapiens_hsa034400.49218677
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48880721
91Circadian rhythm_Homo sapiens_hsa047100.48134966
92Pyrimidine metabolism_Homo sapiens_hsa002400.46829736
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45225559
94Fanconi anemia pathway_Homo sapiens_hsa034600.44388156
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42590557
96Base excision repair_Homo sapiens_hsa034100.42254882
97Glutathione metabolism_Homo sapiens_hsa004800.41652838
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38523118
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38244991
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37903864
101Proteasome_Homo sapiens_hsa030500.37823006
102Vitamin digestion and absorption_Homo sapiens_hsa049770.36839395
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36204952
104Phenylalanine metabolism_Homo sapiens_hsa003600.34658609
105Peroxisome_Homo sapiens_hsa041460.33289746
106Arachidonic acid metabolism_Homo sapiens_hsa005900.32516055
107Legionellosis_Homo sapiens_hsa051340.27350816
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26340757
109VEGF signaling pathway_Homo sapiens_hsa043700.25686394
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25177819
111Renin secretion_Homo sapiens_hsa049240.25109904
112Butanoate metabolism_Homo sapiens_hsa006500.23897360
113Focal adhesion_Homo sapiens_hsa045100.23517540
114Adherens junction_Homo sapiens_hsa045200.21778591
115Melanogenesis_Homo sapiens_hsa049160.21771908
116Mismatch repair_Homo sapiens_hsa034300.20549828
117Fatty acid elongation_Homo sapiens_hsa000620.19437314
118Systemic lupus erythematosus_Homo sapiens_hsa053220.19290780
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18964852
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18730387
121FoxO signaling pathway_Homo sapiens_hsa040680.16670422
122Tyrosine metabolism_Homo sapiens_hsa003500.15721602
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.15189321
124Hedgehog signaling pathway_Homo sapiens_hsa043400.15117166
125Sulfur relay system_Homo sapiens_hsa041220.13555074
126Sulfur metabolism_Homo sapiens_hsa009200.13528467
127Nucleotide excision repair_Homo sapiens_hsa034200.12768792
128Lysine degradation_Homo sapiens_hsa003100.10984545
129Nitrogen metabolism_Homo sapiens_hsa009100.10961893
130beta-Alanine metabolism_Homo sapiens_hsa004100.10567003
131Spliceosome_Homo sapiens_hsa030400.10187919
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.09782393

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