ARTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.66106260
2protoporphyrinogen IX metabolic process (GO:0046501)6.56266537
3protoporphyrinogen IX biosynthetic process (GO:0006782)5.77348989
4bundle of His cell to Purkinje myocyte communication (GO:0086069)5.04357646
5keratinocyte proliferation (GO:0043616)4.96006352
6porphyrin-containing compound biosynthetic process (GO:0006779)4.91741574
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.88758640
8hemidesmosome assembly (GO:0031581)4.83251316
9regulation of water loss via skin (GO:0033561)4.81329813
10establishment of skin barrier (GO:0061436)4.62260837
11regulation of hair follicle development (GO:0051797)4.60386897
12dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.38997497
13prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.35559594
14negative regulation of keratinocyte proliferation (GO:0010839)4.34278045
15heme biosynthetic process (GO:0006783)4.24524786
16positive regulation of epidermis development (GO:0045684)4.20649811
17tetrapyrrole biosynthetic process (GO:0033014)4.16764902
18positive regulation of epidermal cell differentiation (GO:0045606)4.12691470
19GDP-mannose metabolic process (GO:0019673)4.09019323
20regulation of translational fidelity (GO:0006450)4.02267543
21positive regulation of hair cycle (GO:0042635)3.93864196
22positive regulation of hair follicle development (GO:0051798)3.93864196
23cell-substrate adherens junction assembly (GO:0007045)3.93828824
24focal adhesion assembly (GO:0048041)3.93828824
25one-carbon compound transport (GO:0019755)3.93245128
26positive regulation of keratinocyte differentiation (GO:0045618)3.86124251
27erythrocyte maturation (GO:0043249)3.85683431
28mitotic nuclear envelope reassembly (GO:0007084)3.75320859
29nuclear envelope reassembly (GO:0031468)3.75320859
30mesodermal cell differentiation (GO:0048333)3.71793494
31lung lobe morphogenesis (GO:0060463)3.68899120
32surfactant homeostasis (GO:0043129)3.67661566
33porphyrin-containing compound metabolic process (GO:0006778)3.60022764
34activation of Rac GTPase activity (GO:0032863)3.57652137
35epithelial cell differentiation involved in prostate gland development (GO:0060742)3.56296405
36hemoglobin metabolic process (GO:0020027)3.55147937
37semaphorin-plexin signaling pathway (GO:0071526)3.51398558
38regulation of response to osmotic stress (GO:0047484)3.48450512
39regulation of hippo signaling (GO:0035330)3.47385430
40proline biosynthetic process (GO:0006561)3.46037624
41protein localization to endosome (GO:0036010)3.44104007
42branching involved in prostate gland morphogenesis (GO:0060442)3.34036647
43apoptotic process involved in morphogenesis (GO:0060561)3.30986473
44polarized epithelial cell differentiation (GO:0030859)3.28440128
45regulation of mammary gland epithelial cell proliferation (GO:0033599)3.24558200
46cell-substrate junction assembly (GO:0007044)3.24131436
47erythrocyte development (GO:0048821)3.20379057
48mitotic sister chromatid segregation (GO:0000070)3.16940535
49regulation of epidermis development (GO:0045682)3.16323557
50sister chromatid segregation (GO:0000819)3.16034096
51paraxial mesoderm development (GO:0048339)3.14410106
52bone trabecula formation (GO:0060346)3.12925149
53endodermal cell differentiation (GO:0035987)3.12169079
54negative regulation of chondrocyte differentiation (GO:0032331)3.11510278
55regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.11138750
56cellular response to virus (GO:0098586)3.09551876
57folic acid-containing compound biosynthetic process (GO:0009396)3.08998097
58embryonic skeletal joint morphogenesis (GO:0060272)3.07713815
59cytoskeletal anchoring at plasma membrane (GO:0007016)3.07274725
60positive regulation of fibroblast migration (GO:0010763)3.06467993
61skin morphogenesis (GO:0043589)3.06176997
62heme metabolic process (GO:0042168)3.04959839
63negative regulation of cell junction assembly (GO:1901889)3.04465162
64negative regulation of adherens junction organization (GO:1903392)3.04465162
65negative regulation of focal adhesion assembly (GO:0051895)3.04465162
66gap junction assembly (GO:0016264)3.04100806
67chemical homeostasis within a tissue (GO:0048875)3.03909347
68planar cell polarity pathway involved in neural tube closure (GO:0090179)3.02428482
69positive regulation of chromosome segregation (GO:0051984)3.00291191
70hippo signaling (GO:0035329)2.96365522
71regulation of keratinocyte proliferation (GO:0010837)2.94962637
72chondrocyte proliferation (GO:0035988)2.94837323
73pinocytosis (GO:0006907)2.94600536
74negative regulation of cell fate specification (GO:0009996)2.92095615
75negative regulation of fatty acid transport (GO:2000192)2.92036088
76cell differentiation involved in embryonic placenta development (GO:0060706)2.91026925
77maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.90874115
78UV protection (GO:0009650)2.90650662
79mannose metabolic process (GO:0006013)2.89160492
80regulation of hair cycle (GO:0042634)2.89092376
81keratinocyte development (GO:0003334)2.88906217
82regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88245754
83wound healing, spreading of epidermal cells (GO:0035313)2.87331422
84exocrine pancreas development (GO:0031017)2.87060587
85protein targeting to plasma membrane (GO:0072661)2.86932109
86negative regulation of cell aging (GO:0090344)2.86674674
87Golgi transport vesicle coating (GO:0048200)2.85113804
88COPI coating of Golgi vesicle (GO:0048205)2.85113804
89regulation of integrin-mediated signaling pathway (GO:2001044)2.85008945
90decidualization (GO:0046697)2.84211400
91protein localization to chromosome, centromeric region (GO:0071459)2.83526190
92positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.81958698
93cell adhesion mediated by integrin (GO:0033627)2.81271120
94regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.81007017
95response to lead ion (GO:0010288)2.80997629
96regulation of vitamin D biosynthetic process (GO:0060556)2.80853051
97epithelial cell-cell adhesion (GO:0090136)2.80483672
98collagen fibril organization (GO:0030199)2.79209592
99metanephric mesenchyme development (GO:0072075)2.78981548
100multicellular organismal water homeostasis (GO:0050891)2.78212233
101G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.77549300
102atrioventricular valve morphogenesis (GO:0003181)2.76018982
103outer ear morphogenesis (GO:0042473)2.75929439
104peptidyl-proline hydroxylation (GO:0019511)2.75767013
105epidermis development (GO:0008544)2.75491183
106peptidyl-tyrosine autophosphorylation (GO:0038083)2.71677473
107regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.71580220
108positive regulation of Rho protein signal transduction (GO:0035025)2.71325600
109regulation of mitotic spindle organization (GO:0060236)2.70314199
110chromosome condensation (GO:0030261)2.70301523
111negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.69016788
112trophoblast giant cell differentiation (GO:0060707)2.68120454
113lung vasculature development (GO:0060426)2.66856656
114intermediate filament organization (GO:0045109)2.64813730
115regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.64405000
116lung-associated mesenchyme development (GO:0060484)2.63529538
117cell junction assembly (GO:0034329)2.62674257
118DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.62636968
119protein retention in ER lumen (GO:0006621)2.61020674
120hair cycle (GO:0042633)2.60015689
121molting cycle (GO:0042303)2.60015689
122response to arsenic-containing substance (GO:0046685)2.59686146
123mitotic G1 DNA damage checkpoint (GO:0031571)2.58708609
124bicarbonate transport (GO:0015701)2.58363472
125L-alpha-amino acid transmembrane transport (GO:1902475)2.58190765
126positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.57757743
127positive regulation of mitotic sister chromatid separation (GO:1901970)2.57757743
128positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.57757743
129branching involved in mammary gland duct morphogenesis (GO:0060444)2.57440285
130negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.56676786
131activation of MAPKKK activity (GO:0000185)2.56661508
132actin filament bundle organization (GO:0061572)2.56349215
133actin filament bundle assembly (GO:0051017)2.56349215
134morphogenesis of embryonic epithelium (GO:0016331)2.55646709
135positive regulation of Cdc42 GTPase activity (GO:0043089)2.55589657
136hypotonic response (GO:0006971)2.55469353
137endocytic recycling (GO:0032456)2.54288242
138rRNA transcription (GO:0009303)2.53576557
139negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.53492585
140mitotic G1/S transition checkpoint (GO:0044819)2.52553776
141protein localization to kinetochore (GO:0034501)2.52465665
142protein complex localization (GO:0031503)2.52425031
143labyrinthine layer blood vessel development (GO:0060716)2.52398078
144serine transport (GO:0032329)2.52026680
145regulation of epidermal cell differentiation (GO:0045604)2.51996497
146maternal placenta development (GO:0001893)2.51935538
147modulation by symbiont of host cellular process (GO:0044068)2.51329930
148proximal/distal pattern formation (GO:0009954)2.51209840
149renal system development (GO:0072001)2.50955162
150establishment of apical/basal cell polarity (GO:0035089)2.50461261
151kidney mesenchyme development (GO:0072074)2.50356071
152pyrimidine-containing compound salvage (GO:0008655)2.49567471
153pyrimidine nucleoside salvage (GO:0043097)2.49567471
154regulation of keratinocyte differentiation (GO:0045616)2.49525568
155iron ion import (GO:0097286)2.49499340
156negative regulation of cell size (GO:0045792)2.49450840
157heterochromatin organization (GO:0070828)2.47730948
158regulation of apoptotic process involved in morphogenesis (GO:1902337)2.47492207
159peptidyl-arginine omega-N-methylation (GO:0035247)2.47078564
160negative regulation of smooth muscle cell migration (GO:0014912)2.47005297
161actin filament capping (GO:0051693)2.46160985
162establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.45816807
163DNA unwinding involved in DNA replication (GO:0006268)2.45722191
164glucose catabolic process (GO:0006007)2.45129904
165response to methylmercury (GO:0051597)2.44826158
166cell junction organization (GO:0034330)2.44171758
167mammary gland epithelial cell differentiation (GO:0060644)2.44099113
168positive regulation of osteoblast proliferation (GO:0033690)2.44028442
169regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.42122951
170regulation of glucose import in response to insulin stimulus (GO:2001273)2.42071430
171positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.41908090
172positive regulation of cell cycle G2/M phase transition (GO:1902751)2.41908090
173cellular protein complex localization (GO:0034629)2.41724764
174tRNA methylation (GO:0030488)2.41641625
175protein heterotrimerization (GO:0070208)2.41293927
176ribosomal small subunit biogenesis (GO:0042274)2.40728891
177microtubule depolymerization (GO:0007019)2.39054520
178adherens junction assembly (GO:0034333)2.38843379
179embryonic cranial skeleton morphogenesis (GO:0048701)2.38799222
180organ induction (GO:0001759)2.38711915
181positive regulation of p38MAPK cascade (GO:1900745)2.38471313
182negative regulation of actin filament depolymerization (GO:0030835)2.38457590
183protein hydroxylation (GO:0018126)2.38019777
184response to insecticide (GO:0017085)2.37441838
185positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.37248835
186regulation of tight junction assembly (GO:2000810)2.36952046
187regulation of spindle organization (GO:0090224)2.36748450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.03591725
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.95671956
3E2F7_22180533_ChIP-Seq_HELA_Human4.57937416
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.50387666
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41925190
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.21669577
7ZNF263_19887448_ChIP-Seq_K562_Human3.18641436
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.82737900
9* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.73661747
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.57473786
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10950536
12EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.10871391
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.06954407
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99936417
15GATA1_19941826_ChIP-Seq_K562_Human1.97548128
16RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.95689568
17EGR1_19374776_ChIP-ChIP_THP-1_Human1.89385835
18AR_21909140_ChIP-Seq_LNCAP_Human1.87231591
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82827826
20ATF3_27146783_Chip-Seq_COLON_Human1.77411847
21* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.76145791
22* ELK3_25401928_ChIP-Seq_HUVEC_Human1.73568542
23* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72698689
24* RACK7_27058665_Chip-Seq_MCF-7_Human1.72460733
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69530032
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67883460
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65481837
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64314944
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59828633
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56088792
31P68_20966046_ChIP-Seq_HELA_Human1.55955595
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.55535023
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54819935
34CLOCK_20551151_ChIP-Seq_293T_Human1.54280338
35TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52873646
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52412182
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52138686
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.52080602
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52049012
40* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50089709
41* VDR_24763502_ChIP-Seq_THP-1_Human1.48635555
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.48593434
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47895636
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47859934
45SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47288598
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46352306
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44874812
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44143509
49MYC_22102868_ChIP-Seq_BL_Human1.43639771
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42580370
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42462296
52KDM2B_26808549_Chip-Seq_K562_Human1.42099294
53* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.40182063
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39442245
55KDM2B_26808549_Chip-Seq_DND41_Human1.37060236
56NCOR1_26117541_ChIP-Seq_K562_Human1.36929862
57* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33150319
58* LXR_22292898_ChIP-Seq_THP-1_Human1.33041978
59* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31491898
60* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31491898
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.31369941
62TP53_22127205_ChIP-Seq_IMR90_Human1.31011202
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30977526
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29318919
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27712745
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27137037
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26879306
68MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26240973
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24069143
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22992205
71GATA6_25053715_ChIP-Seq_YYC3_Human1.21600921
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21221362
73UBF1/2_26484160_Chip-Seq_HMECs_Human1.19675900
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19158334
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18999990
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18598662
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18518145
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.18343240
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17188228
80* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17053098
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15753605
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15627773
83DCP1A_22483619_ChIP-Seq_HELA_Human1.15146162
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14720551
85* CREB1_26743006_Chip-Seq_LNCaP_Human1.14384076
86ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13056322
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12862092
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12540147
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12535703
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12463182
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12239819
92SMC4_20622854_ChIP-Seq_HELA_Human1.11967324
93MYC_18555785_ChIP-Seq_MESCs_Mouse1.10452144
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09859672
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09782475
96KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09605377
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09605377
98KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09605377
99TCF7_22412390_ChIP-Seq_EML_Mouse1.09207256
100* MAF_26560356_Chip-Seq_TH2_Human1.08384547
101KLF5_25053715_ChIP-Seq_YYC3_Human1.07809569
102* MAF_26560356_Chip-Seq_TH1_Human1.07607872
103* TP63_22573176_ChIP-Seq_HFKS_Human1.07004950
104BCOR_27268052_Chip-Seq_Bcells_Human1.06465408
105* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05938608
106CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05514677
107JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05344717
108SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05261146
109ELF1_20517297_ChIP-Seq_JURKAT_Human1.04703432
110ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03440357
111SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02676881
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02571071
113GATA2_19941826_ChIP-Seq_K562_Human1.01683107
114ESR1_21235772_ChIP-Seq_MCF-7_Human1.00271556
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00197110
116CHD1_26751641_Chip-Seq_LNCaP_Human1.00029100
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99077244
118THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98823883
119EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98767898
120* SA1_27219007_Chip-Seq_ERYTHROID_Human0.98554124
121KDM2B_26808549_Chip-Seq_JURKAT_Human0.98216856
122RARA_24833708_ChIP-Seq_LIVER_Mouse0.97325466
123E2F1_20622854_ChIP-Seq_HELA_Human0.97323741
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97201292
125CTCF_27219007_Chip-Seq_Bcells_Human0.96256303
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95962636
127* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95041162
128* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94917247
129NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94842847
130GATA1_19941827_ChIP-Seq_MEL_Mouse0.94548691
131* VDR_21846776_ChIP-Seq_THP-1_Human0.94160908
132RARB_24833708_ChIP-Seq_LIVER_Mouse0.93782372
133* CTCF_21964334_Chip-Seq_Bcells_Human0.93563180
134NANOG_21062744_ChIP-ChIP_HESCs_Human0.92846542
135SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92744952
136RUNX1_27514584_Chip-Seq_MCF-7_Human0.92210370
137SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91948630
138XRN2_22483619_ChIP-Seq_HELA_Human0.90803005

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.40527510
2MP0003705_abnormal_hypodermis_morpholog4.26894662
3MP0003656_abnormal_erythrocyte_physiolo3.86246821
4MP0008438_abnormal_cutaneous_collagen3.61027610
5MP0010352_gastrointestinal_tract_polyps2.96417983
6MP0000537_abnormal_urethra_morphology2.65055383
7MP0005409_darkened_coat_color2.63302937
8MP0005275_abnormal_skin_tensile2.57358207
9MP0003123_paternal_imprinting2.41207391
10MP0002877_abnormal_melanocyte_morpholog2.37402505
11MP0003111_abnormal_nucleus_morphology2.21932269
12MP0001346_abnormal_lacrimal_gland2.19634618
13MP0004381_abnormal_hair_follicle2.19089639
14MP0005451_abnormal_body_composition2.15712376
15MP0002098_abnormal_vibrissa_morphology2.11697865
16MP0002060_abnormal_skin_morphology2.11647610
17MP0005083_abnormal_biliary_tract2.09582488
18MP0009053_abnormal_anal_canal2.06283347
19MP0005623_abnormal_meninges_morphology2.01315448
20MP0008260_abnormal_autophagy2.00997822
21MP0002234_abnormal_pharynx_morphology1.98590548
22MP0010678_abnormal_skin_adnexa1.97636999
23MP0005076_abnormal_cell_differentiation1.91567978
24MP0004147_increased_porphyrin_level1.90658742
25MP0005503_abnormal_tendon_morphology1.89445594
26MP0003566_abnormal_cell_adhesion1.89177054
27MP0004185_abnormal_adipocyte_glucose1.86127976
28MP0008789_abnormal_olfactory_epithelium1.77371006
29MP0002254_reproductive_system_inflammat1.76089714
30MP0001849_ear_inflammation1.74148528
31MP0000733_abnormal_muscle_development1.70353910
32MP0000383_abnormal_hair_follicle1.66561843
33MP0005023_abnormal_wound_healing1.64946164
34MP0000377_abnormal_hair_follicle1.64159327
35MP0000762_abnormal_tongue_morphology1.63869795
36MP0003385_abnormal_body_wall1.63223833
37MP0000566_synostosis1.62816163
38MP0003937_abnormal_limbs/digits/tail_de1.58696927
39MP0004947_skin_inflammation1.57159047
40MP0003942_abnormal_urinary_system1.56765081
41MP0003279_aneurysm1.54881208
42MP0003453_abnormal_keratinocyte_physiol1.49788868
43MP0006054_spinal_hemorrhage1.48986835
44MP0005508_abnormal_skeleton_morphology1.46933564
45MP0000534_abnormal_ureter_morphology1.46928204
46MP0009250_abnormal_appendicular_skeleto1.43977166
47MP0003941_abnormal_skin_development1.42371065
48MP0003693_abnormal_embryo_hatching1.41476359
49MP0005501_abnormal_skin_physiology1.39754515
50MP0000049_abnormal_middle_ear1.39704423
51MP0010234_abnormal_vibrissa_follicle1.38196897
52MP0004272_abnormal_basement_membrane1.35796148
53MP0004858_abnormal_nervous_system1.34988600
54MP0000428_abnormal_craniofacial_morphol1.33457168
55MP0005058_abnormal_lysosome_morphology1.33402234
56MP0003077_abnormal_cell_cycle1.28829586
57MP0002089_abnormal_postnatal_growth/wei1.25631362
58MP0001542_abnormal_bone_strength1.24018115
59MP0000627_abnormal_mammary_gland1.21648096
60MP0000350_abnormal_cell_proliferation1.21564439
61MP0000858_altered_metastatic_potential1.20824070
62MP0004197_abnormal_fetal_growth/weight/1.19827977
63MP0003119_abnormal_digestive_system1.17714897
64MP0004957_abnormal_blastocyst_morpholog1.17702415
65MP0002282_abnormal_trachea_morphology1.17459582
66MP0005248_abnormal_Harderian_gland1.17071702
67MP0003115_abnormal_respiratory_system1.15476263
68MP0005666_abnormal_adipose_tissue1.13850255
69MP0010771_integument_phenotype1.11547999
70MP0000467_abnormal_esophagus_morphology1.09197526
71MP0001348_abnormal_lacrimal_gland1.07946592
72MP0002932_abnormal_joint_morphology1.07738353
73MP0002249_abnormal_larynx_morphology1.07121221
74MP0001661_extended_life_span1.06438962
75MP0001958_emphysema1.05215195
76MP0002796_impaired_skin_barrier1.04406427
77MP0003806_abnormal_nucleotide_metabolis1.04167633
78MP0003091_abnormal_cell_migration1.03306006
79MP0004233_abnormal_muscle_weight1.01907028
80MP0002111_abnormal_tail_morphology1.00432895
81MP0005375_adipose_tissue_phenotype0.98974100
82MP0000003_abnormal_adipose_tissue0.98473690
83MP0002396_abnormal_hematopoietic_system0.98071638
84MP0003755_abnormal_palate_morphology0.97997731
85MP0009931_abnormal_skin_appearance0.97781514
86MP0001730_embryonic_growth_arrest0.97409273
87MP0005360_urolithiasis0.97162541
88MP0009278_abnormal_bone_marrow0.96636947
89MP0000579_abnormal_nail_morphology0.96351349
90MP0000367_abnormal_coat/_hair0.96109373
91MP0003315_abnormal_perineum_morphology0.93573587
92MP0005394_taste/olfaction_phenotype0.92673755
93MP0005499_abnormal_olfactory_system0.92673755
94MP0005367_renal/urinary_system_phenotyp0.92237255
95MP0000516_abnormal_urinary_system0.92237255
96MP0001191_abnormal_skin_condition0.91727037
97MP0008007_abnormal_cellular_replicative0.91449887
98MP0004782_abnormal_surfactant_physiolog0.90710582
99MP0008770_decreased_survivor_rate0.89390568
100MP0005257_abnormal_intraocular_pressure0.89134167
101MP0002085_abnormal_embryonic_tissue0.88546555
102MP0002233_abnormal_nose_morphology0.88476955
103MP0003121_genomic_imprinting0.87509522
104MP0010094_abnormal_chromosome_stability0.87201954
105MP0000163_abnormal_cartilage_morphology0.86861786
106MP0002697_abnormal_eye_size0.86492067
107MP0001216_abnormal_epidermal_layer0.85802587
108MP0005621_abnormal_cell_physiology0.85541263
109MP0005380_embryogenesis_phenotype0.83044979
110MP0001672_abnormal_embryogenesis/_devel0.83044979
111MP0004264_abnormal_extraembryonic_tissu0.82808715
112MP0001243_abnormal_dermal_layer0.81631891
113MP0002088_abnormal_embryonic_growth/wei0.81136679
114MP0008932_abnormal_embryonic_tissue0.80234165
115MP0002653_abnormal_ependyma_morphology0.79842892
116MP0003787_abnormal_imprinting0.79617940
117MP0002084_abnormal_developmental_patter0.78926299
118MP0000678_abnormal_parathyroid_gland0.78799372
119MP0010307_abnormal_tumor_latency0.78626216
120MP0005330_cardiomyopathy0.78536262
121MP0000490_abnormal_crypts_of0.78040982
122MP0001545_abnormal_hematopoietic_system0.76300444
123MP0005397_hematopoietic_system_phenotyp0.76300444
124MP0002080_prenatal_lethality0.75844703
125MP0003935_abnormal_craniofacial_develop0.75633752
126MP0003786_premature_aging0.75427556
127MP0002086_abnormal_extraembryonic_tissu0.75399283
128MP0002896_abnormal_bone_mineralization0.74812062
129MP0003172_abnormal_lysosome_physiology0.74648927
130MP0000750_abnormal_muscle_regeneration0.73622070
131MP0003984_embryonic_growth_retardation0.73560324
132MP0002116_abnormal_craniofacial_bone0.73257044
133MP0000647_abnormal_sebaceous_gland0.73111555
134MP0002925_abnormal_cardiovascular_devel0.72532956
135MP0009840_abnormal_foam_cell0.72142031
136MP0000470_abnormal_stomach_morphology0.71001224
137MP0003448_altered_tumor_morphology0.69161937
138MP0001881_abnormal_mammary_gland0.68415214
139MP0003191_abnormal_cellular_cholesterol0.63702346
140MP0005384_cellular_phenotype0.62899489
141* MP0001340_abnormal_eyelid_morphology0.60289844
142MP0000358_abnormal_cell_content/0.60084112
143MP0004808_abnormal_hematopoietic_stem0.59071717
144MP0000013_abnormal_adipose_tissue0.58869348
145MP0009672_abnormal_birth_weight0.55703717
146MP0005197_abnormal_uvea_morphology0.55325761
147MP0003303_peritoneal_inflammation0.54029574
148MP0001919_abnormal_reproductive_system0.53999787
149MP0000751_myopathy0.53945920

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)5.98994970
2Premature rupture of membranes (HP:0001788)5.66675760
3Thick nail (HP:0001805)5.54450814
4Atrophic scars (HP:0001075)4.86147710
5Poikilocytosis (HP:0004447)4.63811519
6Ridged nail (HP:0001807)4.56678380
7Protrusio acetabuli (HP:0003179)4.36865794
8Reticulocytosis (HP:0001923)4.18542109
9Abnormality of the heme biosynthetic pathway (HP:0010472)4.17456052
10Onycholysis (HP:0001806)4.04981363
11Milia (HP:0001056)3.84435519
12Palmoplantar hyperkeratosis (HP:0000972)3.83610690
13Shallow orbits (HP:0000586)3.65709638
14Fragile skin (HP:0001030)3.63189908
15Palmar hyperkeratosis (HP:0010765)3.53103273
16Abnormal hair laboratory examination (HP:0003328)3.40897461
17Hypoplasia of dental enamel (HP:0006297)3.27694543
18Squamous cell carcinoma (HP:0002860)3.07396552
19Selective tooth agenesis (HP:0001592)3.06331701
20Ankle contracture (HP:0006466)3.00943770
21Popliteal pterygium (HP:0009756)2.91787094
22Distal lower limb muscle weakness (HP:0009053)2.87342993
23Sparse eyelashes (HP:0000653)2.87322472
24Ulnar bowing (HP:0003031)2.86086365
25Sparse scalp hair (HP:0002209)2.85993223
26Broad face (HP:0000283)2.85125769
27Thin bony cortex (HP:0002753)2.84640025
28Acanthocytosis (HP:0001927)2.80049413
29Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.76215890
30Short 4th metacarpal (HP:0010044)2.76215890
31Genu recurvatum (HP:0002816)2.73279348
32Amniotic constriction ring (HP:0009775)2.66958703
33Abnormality of placental membranes (HP:0011409)2.66958703
34Ankyloglossia (HP:0010296)2.64003017
35Difficulty climbing stairs (HP:0003551)2.62819621
36Breast hypoplasia (HP:0003187)2.60959399
37Abnormality of dentin (HP:0010299)2.60281795
38Abnormality of reticulocytes (HP:0004312)2.59642745
39Pili torti (HP:0003777)2.58738305
40Dry hair (HP:0011359)2.56367913
41Fragile nails (HP:0001808)2.54738556
42Peritonitis (HP:0002586)2.53944291
43Aortic dissection (HP:0002647)2.51687752
44Trismus (HP:0000211)2.47565745
45Fatigable weakness (HP:0003473)2.44732919
46Abnormality of the neuromuscular junction (HP:0003398)2.44732919
47Poikiloderma (HP:0001029)2.43375049
48Short nail (HP:0001799)2.42876743
49Aplasia cutis congenita (HP:0001057)2.39044545
50Down-sloping shoulders (HP:0200021)2.39037624
51Natal tooth (HP:0000695)2.35385471
52Broad distal phalanx of finger (HP:0009836)2.34596916
53Bladder diverticulum (HP:0000015)2.34302992
54Lip pit (HP:0100267)2.33337696
55Pterygium (HP:0001059)2.32685224
56Soft skin (HP:0000977)2.31547175
57Testicular atrophy (HP:0000029)2.31518849
58Anonychia (HP:0001798)2.31427357
59Abnormality of oral frenula (HP:0000190)2.31383784
60Dilatation of the ascending aorta (HP:0005111)2.31275204
61Mitral valve prolapse (HP:0001634)2.30896708
62Alopecia of scalp (HP:0002293)2.29166425
63Hypotrichosis (HP:0001006)2.28663990
64Neonatal short-limb short stature (HP:0008921)2.28276134
65Abnormality of the salivary glands (HP:0010286)2.28114024
66Cerebral aneurysm (HP:0004944)2.25435832
67Hyperacusis (HP:0010780)2.24331103
68Oral leukoplakia (HP:0002745)2.23686752
69Cholelithiasis (HP:0001081)2.21602382
70Abnormality of the distal phalanges of the toes (HP:0010182)2.20709168
71Oligodontia (HP:0000677)2.20455104
72Cheilitis (HP:0100825)2.20381552
73Rectal prolapse (HP:0002035)2.19613349
74Bowed forearm bones (HP:0003956)2.16354698
75Bowing of the arm (HP:0006488)2.16354698
76Flat acetabular roof (HP:0003180)2.14989419
77Diaphragmatic weakness (HP:0009113)2.13443011
78Abnormality of cells of the erythroid lineage (HP:0012130)2.10909909
79Abnormality of the umbilical cord (HP:0010881)2.10875083
80Cervical subluxation (HP:0003308)2.10595156
81Deviation of the hallux (HP:0010051)2.09856263
82Rough bone trabeculation (HP:0100670)2.07230916
83Increased connective tissue (HP:0009025)2.06198017
84Hallux valgus (HP:0001822)2.06128335
85Abnormal trabecular bone morphology (HP:0100671)2.05477962
86Wormian bones (HP:0002645)2.05334707
87Osteomalacia (HP:0002749)2.05188867
88Abnormality of the 4th metacarpal (HP:0010012)2.05082179
89Mildly elevated creatine phosphokinase (HP:0008180)2.05064792
90Hepatoblastoma (HP:0002884)2.01692529
91Pustule (HP:0200039)2.01575247
92Carious teeth (HP:0000670)2.00597577
93Abnormality of the distal phalanx of the thumb (HP:0009617)1.99648630
94Distal lower limb amyotrophy (HP:0008944)1.98588068
95Woolly hair (HP:0002224)1.98212405
96Increased density of long bones (HP:0006392)1.98011990
97Osteolytic defects of the hand bones (HP:0009699)1.97249373
98Osteolytic defects of the phalanges of the hand (HP:0009771)1.97249373
99Elbow flexion contracture (HP:0002987)1.95850774
100Nail dystrophy (HP:0008404)1.94471466
101Achilles tendon contracture (HP:0001771)1.92894805
102Hypochromic microcytic anemia (HP:0004840)1.91313766
103Absent eyelashes (HP:0000561)1.90953573
104Plantar hyperkeratosis (HP:0007556)1.90650664
105Abnormal umbilical cord blood vessels (HP:0011403)1.90306506
106Single umbilical artery (HP:0001195)1.90306506
107Abnormality of the fetal cardiovascular system (HP:0010948)1.90306506
108Nasolacrimal duct obstruction (HP:0000579)1.90024692
109Ureteral duplication (HP:0000073)1.89462725
110Overgrowth (HP:0001548)1.89095708
111Blue sclerae (HP:0000592)1.88413462
112Abnormal gallbladder morphology (HP:0012437)1.86844995
113Progressive muscle weakness (HP:0003323)1.86220043
114Polygenic inheritance (HP:0010982)1.85708380
115Hypoplastic labia majora (HP:0000059)1.85173812
116Slender build (HP:0001533)1.84337695
117Insomnia (HP:0100785)1.83323809
118Aortic aneurysm (HP:0004942)1.82930764
119Short middle phalanx of the 5th finger (HP:0004220)1.82916459
120Radial bowing (HP:0002986)1.82858976
121Deviation of the thumb (HP:0009603)1.81970801
122Wrist flexion contracture (HP:0001239)1.81346833
123Ureteral stenosis (HP:0000071)1.81147957
124Slender long bone (HP:0003100)1.80944336
125Abnormality of the labia majora (HP:0012881)1.79061727
126Abnormal blistering of the skin (HP:0008066)1.77969893
127Amelogenesis imperfecta (HP:0000705)1.77856298
128Long palpebral fissure (HP:0000637)1.77060128
129Abnormal number of incisors (HP:0011064)1.75938170
130Death in infancy (HP:0001522)1.75798797
131Paralysis (HP:0003470)1.74449618
132Abnormality of the fingernails (HP:0001231)1.73322334
133Upper limb amyotrophy (HP:0009129)1.73271997
134Distal upper limb amyotrophy (HP:0007149)1.73271997
135Flattened epiphyses (HP:0003071)1.72471152
136Septate vagina (HP:0001153)1.72394521
137Abnormalities of placenta or umbilical cord (HP:0001194)1.72142012
138Bronchomalacia (HP:0002780)1.71746918
139Back pain (HP:0003418)1.71019598
140Abnormal number of erythroid precursors (HP:0012131)1.70816483
141Pelvic girdle muscle weakness (HP:0003749)1.69032563
142Advanced eruption of teeth (HP:0006288)1.68719384
143Broad thumb (HP:0011304)1.68309643
144Spinal cord compression (HP:0002176)1.67535604
145Abnormality of the 2nd finger (HP:0004100)1.67300894
146Renal duplication (HP:0000075)1.66938725
147Mesomelia (HP:0003027)1.65111539
148Morphological abnormality of the middle ear (HP:0008609)1.64904610
149Abnormal delivery (HP:0001787)1.63666306
150Broad toe (HP:0001837)1.63481496
151Hypochromic anemia (HP:0001931)1.62929712
152Malnutrition (HP:0004395)1.62844225
153Hyperhidrosis (HP:0000975)1.62560719
154Neonatal onset (HP:0003623)1.62270585
155Basal cell carcinoma (HP:0002671)1.61939989
156Right ventricular cardiomyopathy (HP:0011663)1.61701444
157Aplasia/Hypoplasia of the patella (HP:0006498)1.61689018
158Abnormality of the Achilles tendon (HP:0005109)1.58555006
159Abnormality of the thoracic spine (HP:0100711)1.53100798
160Delayed epiphyseal ossification (HP:0002663)1.52970665
161Ureteral obstruction (HP:0006000)1.52024740
162Blepharitis (HP:0000498)1.51868263
163Vertebral arch anomaly (HP:0008438)1.51339394
164Erythema (HP:0010783)1.50166724
165Facial hemangioma (HP:0000329)1.49460365
166Stridor (HP:0010307)1.48904435
167Spastic diplegia (HP:0001264)1.48441178
168Hyperparathyroidism (HP:0000843)1.48111542
169Hypodontia (HP:0000668)1.48026266
170Abnormality of the lacrimal duct (HP:0011481)1.47961578
171Split hand (HP:0001171)1.47288141

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.95641824
2EIF2AK13.75149682
3BUB13.69509730
4ARAF3.13605883
5SMG13.12659987
6IRAK33.04676689
7TRIB32.73238488
8MAPK152.58359345
9LATS12.43732868
10LATS22.26062892
11TTN2.13259815
12BMX1.97083834
13EPHB21.94058867
14DDR21.92135884
15EEF2K1.90530152
16MAP3K101.84433671
17NEK21.84281132
18PKN21.83598948
19RPS6KB21.80294036
20PTK21.79270927
21STK38L1.77643349
22PRPF4B1.65123061
23FLT31.64597139
24MAPKAPK31.56355553
25CDK121.53477585
26ICK1.50970461
27BRAF1.49586445
28ERBB31.48489186
29TRPM71.46468492
30DYRK31.43273697
31TAOK11.42875501
32PAK41.40804759
33STK31.40794859
34TESK11.40664221
35STK101.40380200
36ERN11.29636950
37PLK31.29348566
38CDC71.29174391
39RPS6KA41.28381712
40MAP3K81.28273221
41VRK21.27813649
42MAP3K91.27665210
43RIPK11.25231193
44PTK61.25208923
45PDGFRA1.22544478
46BRSK11.21079602
47NTRK11.19396805
48MUSK1.18332219
49TLK11.13568025
50CDK61.11988289
51TAOK21.10554592
52LRRK21.10293606
53PAK21.09779797
54IRAK21.07644026
55WNK41.07084142
56MAP3K31.05234874
57SIK11.05019649
58PLK11.04512577
59DYRK1B1.02332448
60AURKA1.01773514
61TTK1.01567828
62MTOR1.01450314
63MAP3K60.97885859
64ILK0.93873371
65PAK10.93627402
66PRKD20.92089697
67RPS6KL10.91042657
68RPS6KC10.91042657
69PTK2B0.90565604
70STK40.90064141
71TBK10.90050656
72AURKB0.88043957
73MET0.88019420
74MAP2K20.87444861
75MAP2K10.86184192
76MAP3K20.85735883
77CHEK20.84514842
78MOS0.84413826
79ALK0.84026234
80CDC42BPA0.82018121
81PBK0.81029262
82MELK0.80321701
83TESK20.80103044
84PDK40.77886957
85PDK30.77886957
86PDK20.77808312
87CHEK10.71913173
88LMTK20.71546454
89NEK10.68866372
90RPS6KA60.68080964
91FER0.67816904
92MAP3K110.64701613
93RPS6KA10.63486751
94ERBB20.62750282
95NME20.60829938
96PIM20.58425098
97CDK40.57744950
98MAP3K10.57230383
99TGFBR20.57152006
100PRKCI0.56940366
101MAP3K140.56611810
102DMPK0.55464706
103WEE10.55415869
104STK380.54831846
105NME10.54621740
106MAPKAPK20.53817205
107IKBKB0.53213947
108CSF1R0.52631873
109MAP2K30.52225943
110MST1R0.51797974
111MAP3K130.51272799
112PIM10.51024773
113SIK30.49448591
114EPHB10.49180865
115CDK70.49180337
116ABL20.48826842
117CDK150.48295845
118CDK11A0.45169943
119PDGFRB0.42184372
120PDPK10.41724764
121CDK180.40994518
122RAF10.40413187
123CHUK0.40199147
124CDK140.40123385
125HIPK20.39962836
126DAPK20.39834373
127ATM0.39533436
128STK160.39014205
129FGFR10.38430704
130AKT20.37212992
131WNK10.36920351
132PASK0.36824966
133IRAK40.36641090
134ROCK10.36570149
135RPS6KA20.36517171
136PRKD30.36323385
137KSR20.34988920
138TGFBR10.34151322
139CDK90.32650332
140DAPK10.29609362
141CAMK1D0.29263246
142MAP2K60.28861498
143STK240.28567439
144EIF2AK20.27461689

Predicted pathways (KEGG)

RankGene SetZ-score
1Bladder cancer_Homo sapiens_hsa052193.39072554
2Vitamin B6 metabolism_Homo sapiens_hsa007502.93057648
3Cell cycle_Homo sapiens_hsa041102.66945921
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.66089599
5ECM-receptor interaction_Homo sapiens_hsa045122.51026698
6p53 signaling pathway_Homo sapiens_hsa041152.44885227
7Small cell lung cancer_Homo sapiens_hsa052222.41751445
8Hedgehog signaling pathway_Homo sapiens_hsa043402.23204103
9Basal cell carcinoma_Homo sapiens_hsa052172.18961865
10Hippo signaling pathway_Homo sapiens_hsa043902.07316283
11Other glycan degradation_Homo sapiens_hsa005112.03308737
12Proteoglycans in cancer_Homo sapiens_hsa052051.92461833
13MicroRNAs in cancer_Homo sapiens_hsa052061.89521498
14Chronic myeloid leukemia_Homo sapiens_hsa052201.79413337
15Focal adhesion_Homo sapiens_hsa045101.76885076
16Systemic lupus erythematosus_Homo sapiens_hsa053221.71743491
17Adherens junction_Homo sapiens_hsa045201.69785218
18Prostate cancer_Homo sapiens_hsa052151.65208416
19Glioma_Homo sapiens_hsa052141.57292079
20Galactose metabolism_Homo sapiens_hsa000521.50733509
21Base excision repair_Homo sapiens_hsa034101.50517587
22Melanoma_Homo sapiens_hsa052181.49809924
23One carbon pool by folate_Homo sapiens_hsa006701.48859797
24Tight junction_Homo sapiens_hsa045301.47766029
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.46347257
26ErbB signaling pathway_Homo sapiens_hsa040121.44589937
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39107473
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.36571721
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35874593
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33759273
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.32740418
32TGF-beta signaling pathway_Homo sapiens_hsa043501.31087382
33Amoebiasis_Homo sapiens_hsa051461.29148393
34Glutathione metabolism_Homo sapiens_hsa004801.27629171
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.27368219
36Protein digestion and absorption_Homo sapiens_hsa049741.26946060
37HTLV-I infection_Homo sapiens_hsa051661.26586823
38Non-small cell lung cancer_Homo sapiens_hsa052231.26133731
39RNA transport_Homo sapiens_hsa030131.23727207
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23573093
41Apoptosis_Homo sapiens_hsa042101.21083395
42Oocyte meiosis_Homo sapiens_hsa041141.18835243
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18447065
44DNA replication_Homo sapiens_hsa030301.18394625
45N-Glycan biosynthesis_Homo sapiens_hsa005101.18240550
46Sphingolipid metabolism_Homo sapiens_hsa006001.18049836
47Pyrimidine metabolism_Homo sapiens_hsa002401.17326323
48HIF-1 signaling pathway_Homo sapiens_hsa040661.16605253
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.14101700
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12910996
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12643413
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10746539
53Hepatitis C_Homo sapiens_hsa051601.10631007
54Pathways in cancer_Homo sapiens_hsa052001.10094530
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09765274
56Viral carcinogenesis_Homo sapiens_hsa052031.07767639
57Renal cell carcinoma_Homo sapiens_hsa052111.07546366
58Thyroid cancer_Homo sapiens_hsa052161.05026612
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.04498725
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04113096
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00415777
62Malaria_Homo sapiens_hsa051440.98307036
63Prion diseases_Homo sapiens_hsa050200.97505010
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97218416
65mTOR signaling pathway_Homo sapiens_hsa041500.96953110
66Pancreatic cancer_Homo sapiens_hsa052120.96010142
67TNF signaling pathway_Homo sapiens_hsa046680.94585401
68Notch signaling pathway_Homo sapiens_hsa043300.93086717
69Insulin signaling pathway_Homo sapiens_hsa049100.92325771
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91405743
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91040137
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88757271
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88436440
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.87615514
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.87409169
76FoxO signaling pathway_Homo sapiens_hsa040680.87219883
77Wnt signaling pathway_Homo sapiens_hsa043100.87112304
78Salmonella infection_Homo sapiens_hsa051320.85509193
79Dilated cardiomyopathy_Homo sapiens_hsa054140.85277930
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85144803
81Alcoholism_Homo sapiens_hsa050340.84323027
82Endometrial cancer_Homo sapiens_hsa052130.83683968
83mRNA surveillance pathway_Homo sapiens_hsa030150.81179263
84Lysosome_Homo sapiens_hsa041420.79695525
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78903840
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77709914
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77159456
88Ribosome_Homo sapiens_hsa030100.76701852
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76447180
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75456947
91Sulfur metabolism_Homo sapiens_hsa009200.75207338
92Axon guidance_Homo sapiens_hsa043600.73049660
93Steroid biosynthesis_Homo sapiens_hsa001000.72969172
94Mismatch repair_Homo sapiens_hsa034300.71903955
95Melanogenesis_Homo sapiens_hsa049160.71579293
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70434241
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67596790
98Influenza A_Homo sapiens_hsa051640.65279952
99Spliceosome_Homo sapiens_hsa030400.64621281
100Dorso-ventral axis formation_Homo sapiens_hsa043200.63887048
101RNA polymerase_Homo sapiens_hsa030200.63478716
102Estrogen signaling pathway_Homo sapiens_hsa049150.62352032
103Nucleotide excision repair_Homo sapiens_hsa034200.62088289
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61613513
105Toxoplasmosis_Homo sapiens_hsa051450.61270518
106Biosynthesis of amino acids_Homo sapiens_hsa012300.60220997
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.59402631
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59030896
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.58485731
110Gap junction_Homo sapiens_hsa045400.58445025
111Epstein-Barr virus infection_Homo sapiens_hsa051690.56997302
112Insulin resistance_Homo sapiens_hsa049310.56685497
113Hepatitis B_Homo sapiens_hsa051610.55325302
114Colorectal cancer_Homo sapiens_hsa052100.54935834
115Acute myeloid leukemia_Homo sapiens_hsa052210.54208178
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53928545
117Inositol phosphate metabolism_Homo sapiens_hsa005620.52943256
118Endocytosis_Homo sapiens_hsa041440.50158563
119AMPK signaling pathway_Homo sapiens_hsa041520.49777576
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.49727686
121Shigellosis_Homo sapiens_hsa051310.49674118
122VEGF signaling pathway_Homo sapiens_hsa043700.48302296
123Vitamin digestion and absorption_Homo sapiens_hsa049770.47767339
124Thyroid hormone synthesis_Homo sapiens_hsa049180.47647491
125Fructose and mannose metabolism_Homo sapiens_hsa000510.46403511
126Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45599571
127GnRH signaling pathway_Homo sapiens_hsa049120.45246023
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.44157121
129Sulfur relay system_Homo sapiens_hsa041220.43669508
130Chemical carcinogenesis_Homo sapiens_hsa052040.42685805
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42593500
132Folate biosynthesis_Homo sapiens_hsa007900.41668697
133Glucagon signaling pathway_Homo sapiens_hsa049220.40628408
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38837909
135Pentose phosphate pathway_Homo sapiens_hsa000300.38779105
136Mineral absorption_Homo sapiens_hsa049780.38314971
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36936962

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