ARVCF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family. This family plays an important role in the formation of adherens junction complexes, which are thought to facilitate communication between the inside and outside environments of a cell. The ARVCF gene was isolated in the search for the genetic defect responsible for the autosomal dominant Velo-Cardio-Facial syndrome (VCFS), a relatively common human disorder with phenotypic features including cleft palate, conotruncal heart defects and facial dysmorphology. The ARVCF gene encodes a protein containing two motifs, a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence in the midregion. Since these sequences can facilitate protein-protein interactions ARVCF is thought to function in a protein complex. In addition, ARVCF contains a predicted nuclear-targeting sequence suggesting that it may have a function as a nuclear protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular epithelial cell development (GO:0072310)5.45084002
2glomerular basement membrane development (GO:0032836)5.24986092
3glomerular visceral epithelial cell development (GO:0072015)5.19649099
4cell migration in hindbrain (GO:0021535)4.81660849
5pyrimidine nucleobase catabolic process (GO:0006208)4.57907537
6negative regulation of axon guidance (GO:1902668)4.19690033
7glomerulus development (GO:0032835)3.94636381
8planar cell polarity pathway involved in neural tube closure (GO:0090179)3.92242828
9axonal fasciculation (GO:0007413)3.80952649
10regulation of axon guidance (GO:1902667)3.76750665
11synaptic vesicle docking involved in exocytosis (GO:0016081)3.75270235
12establishment of mitochondrion localization (GO:0051654)3.70739461
13paraxial mesoderm development (GO:0048339)3.65372227
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.62050911
15postsynaptic membrane organization (GO:0001941)3.59712974
16layer formation in cerebral cortex (GO:0021819)3.59063804
17neuronal ion channel clustering (GO:0045161)3.58650392
18regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.57487884
19synaptic vesicle maturation (GO:0016188)3.55840545
20establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.51183081
21mitochondrion transport along microtubule (GO:0047497)3.51183081
22lateral sprouting from an epithelium (GO:0060601)3.48396723
23negative regulation of axon extension involved in axon guidance (GO:0048843)3.47940442
24dopaminergic neuron differentiation (GO:0071542)3.38729905
25lung epithelium development (GO:0060428)3.37880221
26regulation of short-term neuronal synaptic plasticity (GO:0048172)3.32889356
27neuron recognition (GO:0008038)3.29149396
28regulation of axon extension involved in axon guidance (GO:0048841)3.27975661
29lung-associated mesenchyme development (GO:0060484)3.27242470
30axon extension involved in axon guidance (GO:0048846)3.25633718
31neuron projection extension involved in neuron projection guidance (GO:1902284)3.25633718
32negative regulation of microtubule polymerization (GO:0031115)3.22150660
33establishment of planar polarity (GO:0001736)3.21415065
34establishment of tissue polarity (GO:0007164)3.21415065
35nucleobase catabolic process (GO:0046113)3.20361894
36vocalization behavior (GO:0071625)3.20095359
37negative regulation of catenin import into nucleus (GO:0035414)3.20062866
38neuronal stem cell maintenance (GO:0097150)3.17681999
39cerebellar granule cell differentiation (GO:0021707)3.17344231
40regulation of hippo signaling (GO:0035330)3.15530890
41dendritic spine morphogenesis (GO:0060997)3.15097409
42establishment of nucleus localization (GO:0040023)3.14109860
43coronary vasculature morphogenesis (GO:0060977)3.12404695
44lens fiber cell development (GO:0070307)3.09837878
45cell junction maintenance (GO:0034331)3.09514625
46sodium ion export (GO:0071436)3.06818722
47positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.00469925
48hippo signaling (GO:0035329)2.99062914
49regulation of synaptic vesicle exocytosis (GO:2000300)2.95828790
50cellular potassium ion homeostasis (GO:0030007)2.94587593
51glutamate secretion (GO:0014047)2.90894930
52regulation of synapse maturation (GO:0090128)2.90336260
53auditory behavior (GO:0031223)2.89967759
54retinal ganglion cell axon guidance (GO:0031290)2.88615420
55sympathetic nervous system development (GO:0048485)2.87505603
56cell-cell junction maintenance (GO:0045217)2.86194846
57collecting duct development (GO:0072044)2.83712164
58regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.83664489
59locomotory exploration behavior (GO:0035641)2.83344882
60midbrain development (GO:0030901)2.81403437
61regulation of synapse structural plasticity (GO:0051823)2.78733827
62positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.76836658
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72778987
64axon extension (GO:0048675)2.70064286
65synaptic vesicle endocytosis (GO:0048488)2.67599422
66protein retention in ER lumen (GO:0006621)2.67236845
67synaptic vesicle exocytosis (GO:0016079)2.66899871
68protein localization to synapse (GO:0035418)2.66861529
69neurotransmitter-gated ion channel clustering (GO:0072578)2.66099988
70limb bud formation (GO:0060174)2.64955736
71neuromuscular process controlling balance (GO:0050885)2.64623938
72apical protein localization (GO:0045176)2.64583402
73neural tube development (GO:0021915)2.63498968
74epithelial cell differentiation involved in kidney development (GO:0035850)2.62766565
75dendritic spine organization (GO:0097061)2.62559469
76cerebral cortex neuron differentiation (GO:0021895)2.62189015
77negative regulation of axon extension (GO:0030517)2.62075238
78central nervous system myelination (GO:0022010)2.61710196
79axon ensheathment in central nervous system (GO:0032291)2.61710196
80central nervous system projection neuron axonogenesis (GO:0021952)2.60940586
81embryonic retina morphogenesis in camera-type eye (GO:0060059)2.60518639
82presynaptic membrane assembly (GO:0097105)2.59700039
83convergent extension (GO:0060026)2.59349246
84positive regulation of synapse maturation (GO:0090129)2.58675585
85establishment or maintenance of monopolar cell polarity (GO:0061339)2.58215980
86establishment of monopolar cell polarity (GO:0061162)2.58215980
87regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.57348538
88exploration behavior (GO:0035640)2.56598461
89astrocyte differentiation (GO:0048708)2.55657073
90potassium ion homeostasis (GO:0055075)2.55342473
91regulation of glutamate receptor signaling pathway (GO:1900449)2.54790910
92spinal cord development (GO:0021510)2.54431130
93presynaptic membrane organization (GO:0097090)2.53368677
94cardiovascular system development (GO:0072358)2.53282974
95dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.52287668
96cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.50939745
97adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.50134758
98neuromuscular junction development (GO:0007528)2.48391138
99innervation (GO:0060384)2.48278961
100dopamine receptor signaling pathway (GO:0007212)2.48066594
101endocardial cushion morphogenesis (GO:0003203)2.47352057
102establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.47247820
103skeletal muscle organ development (GO:0060538)2.47173166
104embryonic foregut morphogenesis (GO:0048617)2.46695504
105regulation of neuronal synaptic plasticity (GO:0048168)2.46388864
106synapse assembly (GO:0007416)2.46126682
107positive regulation of synapse assembly (GO:0051965)2.45034442
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.44519418
109Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.44121620
110respiratory system process (GO:0003016)2.43248078
111semaphorin-plexin signaling pathway (GO:0071526)2.43199177
112cochlea morphogenesis (GO:0090103)2.43028524
113heart valve formation (GO:0003188)2.42864638
114establishment of apical/basal cell polarity (GO:0035089)2.42713236
115positive regulation of gastrulation (GO:2000543)2.42445020
116ionotropic glutamate receptor signaling pathway (GO:0035235)2.42213572
117response to auditory stimulus (GO:0010996)2.41528155
118cytoskeletal anchoring at plasma membrane (GO:0007016)2.39431919
119neuron projection extension (GO:1990138)2.39253171
120regulation of catenin import into nucleus (GO:0035412)2.39243922
121myelination in peripheral nervous system (GO:0022011)2.39055185
122peripheral nervous system axon ensheathment (GO:0032292)2.39055185
123peptidyl-tyrosine autophosphorylation (GO:0038083)2.38072002
124neurotransmitter secretion (GO:0007269)2.37075434
125dendrite morphogenesis (GO:0048813)2.36928926
126regulation of synaptic vesicle transport (GO:1902803)2.36230654
127glial cell proliferation (GO:0014009)2.36197630
128body morphogenesis (GO:0010171)2.36058677
129response to pheromone (GO:0019236)2.35335514
130positive regulation of dendrite development (GO:1900006)2.33447221
131pre-miRNA processing (GO:0031054)2.32352345
132positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.32133291
133camera-type eye morphogenesis (GO:0048593)2.31720097
134left/right axis specification (GO:0070986)2.31567164
135cranial nerve morphogenesis (GO:0021602)2.31369657
136regulation of respiratory system process (GO:0044065)2.31344547
137maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.31229809
138positive regulation of dendritic spine morphogenesis (GO:0061003)2.31049716
139asymmetric protein localization (GO:0008105)2.30722439
140lens morphogenesis in camera-type eye (GO:0002089)2.29454952
141regulation of establishment of planar polarity (GO:0090175)2.29406489
142kidney mesenchyme development (GO:0072074)2.29278145
143peptidyl-arginine omega-N-methylation (GO:0035247)2.29087629
144forebrain neuron differentiation (GO:0021879)2.28920382
145cell migration involved in heart development (GO:0060973)2.28160427
146cardiac ventricle formation (GO:0003211)2.27652697
147renal system development (GO:0072001)2.27303426
148histone arginine methylation (GO:0034969)2.25970182
149neuron cell-cell adhesion (GO:0007158)2.25493124
150nucleus localization (GO:0051647)2.20828681
151cell communication by electrical coupling (GO:0010644)2.20500115
152negative regulation of oligodendrocyte differentiation (GO:0048715)2.20190232
153central nervous system neuron development (GO:0021954)2.19731541
154non-canonical Wnt signaling pathway (GO:0035567)2.18609253
155epithelial cell fate commitment (GO:0072148)2.16248910
156positive regulation of neuroblast proliferation (GO:0002052)2.16024086
157establishment or maintenance of apical/basal cell polarity (GO:0035088)2.15960099
158establishment or maintenance of bipolar cell polarity (GO:0061245)2.15960099
159spinal cord motor neuron differentiation (GO:0021522)2.15802921
160cardiac chamber formation (GO:0003207)2.15240295
161ectodermal placode formation (GO:0060788)2.15065550
162central nervous system neuron axonogenesis (GO:0021955)2.13415570

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.67043368
2EZH2_27304074_Chip-Seq_ESCs_Mouse2.63983453
3ZFP281_18757296_ChIP-ChIP_E14_Mouse2.45709644
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.43578314
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.43575679
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.40185634
7ERG_21242973_ChIP-ChIP_JURKAT_Human2.40085421
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.39203259
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32802981
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32802981
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25577454
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.23597202
13* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.20239755
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.18681703
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17361390
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13965343
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11088509
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.04812253
19TP53_20018659_ChIP-ChIP_R1E_Mouse2.03001670
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99886121
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.95719194
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.95546994
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95537724
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90842268
25RING1B_27294783_Chip-Seq_NPCs_Mouse1.90684692
26* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.90400746
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87708978
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.81701043
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77570222
30ZNF263_19887448_ChIP-Seq_K562_Human1.77428392
31OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.77082937
32ZFP281_27345836_Chip-Seq_ESCs_Mouse1.76498444
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73005642
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72526176
35RING1B_27294783_Chip-Seq_ESCs_Mouse1.71880314
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.69490535
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68845624
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.63895536
39KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.61925409
40* KDM2B_26808549_Chip-Seq_K562_Human1.60944999
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59623744
42SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.59266203
43SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.58805924
44KDM2B_26808549_Chip-Seq_DND41_Human1.53523663
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.53024802
46SMC4_20622854_ChIP-Seq_HELA_Human1.51868385
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.51533925
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.49503935
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48323031
50RACK7_27058665_Chip-Seq_MCF-7_Human1.47578110
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45603766
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42933023
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42539986
54P68_20966046_ChIP-Seq_HELA_Human1.42498355
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40931108
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40546247
57ISL1_27105846_Chip-Seq_CPCs_Mouse1.39416041
58SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38829438
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.35944410
60NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.35612358
61TET1_21490601_ChIP-Seq_MESCs_Mouse1.32663206
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.31070622
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.30535877
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30445175
65NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.30029345
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28754309
67DROSHA_22980978_ChIP-Seq_HELA_Human1.27151748
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.26427608
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26384448
70TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26141453
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.25754932
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.24996249
73REST_21632747_ChIP-Seq_MESCs_Mouse1.24936787
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23078122
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23027247
76FOXM1_23109430_ChIP-Seq_U2OS_Human1.22201289
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.21460231
78KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20883247
79KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20883247
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20883247
81SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20869561
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19869709
83* REST_18959480_ChIP-ChIP_MESCs_Mouse1.19650590
84* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.19189157
85CLOCK_20551151_ChIP-Seq_293T_Human1.19144544
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.18203913
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18185067
88RARB_27405468_Chip-Seq_BRAIN_Mouse1.16195280
89TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.15928850
90CTCF_27219007_Chip-Seq_Bcells_Human1.14249722
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13700018
92SA1_27219007_Chip-Seq_ERYTHROID_Human1.12888795
93TCF7_22412390_ChIP-Seq_EML_Mouse1.12123132
94* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12120276
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11275578
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09262066
97* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08799309
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.07550044
99SOX3_22085726_ChIP-Seq_NPCs_Mouse1.06453186
100TP53_22127205_ChIP-Seq_IMR90_Human1.06426517
101RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06327803
102* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05762863
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04532189
104TP63_19390658_ChIP-ChIP_HaCaT_Human1.04032442
105POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02850751
106GATA1_26923725_Chip-Seq_HPCs_Mouse1.02370541
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01852333
108* TP53_23651856_ChIP-Seq_MEFs_Mouse1.01080282
109RNF2_27304074_Chip-Seq_NSC_Mouse1.00542383
110CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00282000
111KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00084249
112SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99264861
113CREB1_26743006_Chip-Seq_LNCaP_Human0.98418478
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97094487
115SOX2_18692474_ChIP-Seq_MESCs_Mouse0.96994808
116MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96909966
117ESR1_21235772_ChIP-Seq_MCF-7_Human0.96605446
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95987417
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94821518
120CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94761992
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94615881
122OCT4_19829295_ChIP-Seq_ESCs_Human0.93958358
123MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93072500
124UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92803519
125FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92581294
126LXR_22292898_ChIP-Seq_THP-1_Human0.92431977
127TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92427417
128* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92044276
129NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90662203
130CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89348806
131IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88495920
132SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88446347
133* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88148293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.25445047
2MP0010030_abnormal_orbit_morphology3.19554566
3MP0000778_abnormal_nervous_system2.89008117
4MP0000537_abnormal_urethra_morphology2.76000276
5MP0002822_catalepsy2.54815745
6MP0004133_heterotaxia2.43624340
7MP0003283_abnormal_digestive_organ2.28491947
8MP0004858_abnormal_nervous_system2.15696022
9MP0003122_maternal_imprinting2.14004083
10MP0005623_abnormal_meninges_morphology2.13336634
11MP0003942_abnormal_urinary_system2.10493306
12MP0005409_darkened_coat_color1.97424646
13MP0002751_abnormal_autonomic_nervous1.83893327
14MP0000534_abnormal_ureter_morphology1.83351501
15MP0002697_abnormal_eye_size1.78125052
16MP0009053_abnormal_anal_canal1.77659965
17MP0003119_abnormal_digestive_system1.76250244
18MP0005377_hearing/vestibular/ear_phenot1.70590363
19MP0003878_abnormal_ear_physiology1.70590363
20MP0003705_abnormal_hypodermis_morpholog1.70129470
21MP0003861_abnormal_nervous_system1.66797032
22MP0005423_abnormal_somatic_nervous1.65983974
23MP0002234_abnormal_pharynx_morphology1.63159288
24MP0004859_abnormal_synaptic_plasticity1.58388905
25MP0001502_abnormal_circadian_rhythm1.56503329
26MP0003937_abnormal_limbs/digits/tail_de1.55823758
27MP0003879_abnormal_hair_cell1.53736508
28MP0000049_abnormal_middle_ear1.52572042
29MP0003938_abnormal_ear_development1.51429596
30MP0002249_abnormal_larynx_morphology1.50242358
31MP0003385_abnormal_body_wall1.44825133
32MP0004233_abnormal_muscle_weight1.44767019
33MP0000955_abnormal_spinal_cord1.44618722
34MP0005187_abnormal_penis_morphology1.44140420
35MP0006276_abnormal_autonomic_nervous1.43631548
36MP0002184_abnormal_innervation1.43391481
37MP0008789_abnormal_olfactory_epithelium1.42211736
38MP0004272_abnormal_basement_membrane1.41918713
39MP0000428_abnormal_craniofacial_morphol1.40477488
40MP0003121_genomic_imprinting1.37746183
41MP0002092_abnormal_eye_morphology1.36557724
42MP0003115_abnormal_respiratory_system1.35255700
43MP0000462_abnormal_digestive_system1.34346191
44MP0000566_synostosis1.33447567
45MP0001486_abnormal_startle_reflex1.33240378
46MP0002152_abnormal_brain_morphology1.31326865
47MP0002064_seizures1.30296282
48MP0002102_abnormal_ear_morphology1.27149478
49MP0001984_abnormal_olfaction1.26933635
50MP0001286_abnormal_eye_development1.26556953
51MP0003755_abnormal_palate_morphology1.26055306
52MP0002282_abnormal_trachea_morphology1.24982153
53MP0003329_amyloid_beta_deposits1.24852853
54MP0005394_taste/olfaction_phenotype1.24591093
55MP0005499_abnormal_olfactory_system1.24591093
56MP0000631_abnormal_neuroendocrine_gland1.23463710
57MP0003315_abnormal_perineum_morphology1.23399294
58MP0003137_abnormal_impulse_conducting1.23372917
59MP0005257_abnormal_intraocular_pressure1.22465997
60MP0004145_abnormal_muscle_electrophysio1.22033437
61MP0001299_abnormal_eye_distance/1.21309352
62MP0004084_abnormal_cardiac_muscle1.21012538
63MP0006072_abnormal_retinal_apoptosis1.19609484
64MP0002638_abnormal_pupillary_reflex1.19158856
65MP0002272_abnormal_nervous_system1.18908226
66MP0004270_analgesia1.18884493
67MP0001849_ear_inflammation1.18229935
68MP0003935_abnormal_craniofacial_develop1.15145369
69MP0002233_abnormal_nose_morphology1.13404276
70MP0002116_abnormal_craniofacial_bone1.12528058
71MP0002084_abnormal_developmental_patter1.12149801
72MP0003635_abnormal_synaptic_transmissio1.11674777
73MP0002882_abnormal_neuron_morphology1.11235430
74MP0009379_abnormal_foot_pigmentation1.11058363
75MP0001293_anophthalmia1.10941304
76MP0005248_abnormal_Harderian_gland1.08475729
77MP0000467_abnormal_esophagus_morphology1.07697289
78MP0003880_abnormal_central_pattern1.07248880
79MP0003941_abnormal_skin_development1.06845992
80MP0009745_abnormal_behavioral_response1.05894409
81MP0003123_paternal_imprinting1.05677070
82MP0006292_abnormal_olfactory_placode1.05620540
83MP0002085_abnormal_embryonic_tissue1.05017713
84MP0008569_lethality_at_weaning1.04578453
85MP0002063_abnormal_learning/memory/cond1.04442062
86MP0001970_abnormal_pain_threshold1.04041268
87MP0001188_hyperpigmentation1.03920075
88MP0000026_abnormal_inner_ear1.02013627
89MP0002752_abnormal_somatic_nervous1.01455296
90MP0002081_perinatal_lethality1.00188098
91MP0004885_abnormal_endolymph0.99929330
92MP0004811_abnormal_neuron_physiology0.99893837
93MP0003136_yellow_coat_color0.99175486
94MP0002932_abnormal_joint_morphology0.98503431
95MP0002735_abnormal_chemical_nociception0.98487057
96MP0000762_abnormal_tongue_morphology0.97338023
97MP0003890_abnormal_embryonic-extraembry0.96282322
98MP0005391_vision/eye_phenotype0.95839244
99MP0001529_abnormal_vocalization0.95387616
100MP0000579_abnormal_nail_morphology0.94984621
101MP0009780_abnormal_chondrocyte_physiolo0.91628466
102MP0000678_abnormal_parathyroid_gland0.91570589
103MP0000751_myopathy0.91367810
104MP0001968_abnormal_touch/_nociception0.90010114
105MP0002066_abnormal_motor_capabilities/c0.89130073
106MP0002557_abnormal_social/conspecific_i0.89058486
107MP0008961_abnormal_basal_metabolism0.88978025
108MP0002734_abnormal_mechanical_nocicepti0.88643046
109MP0010368_abnormal_lymphatic_system0.85894057
110MP0003787_abnormal_imprinting0.84282341
111MP0003634_abnormal_glial_cell0.81739308
112MP0001348_abnormal_lacrimal_gland0.81733161
113MP0001440_abnormal_grooming_behavior0.81422070
114MP0000747_muscle_weakness0.80754553
115MP0003567_abnormal_fetal_cardiomyocyte0.80257780
116MP0005197_abnormal_uvea_morphology0.79222785
117MP0005193_abnormal_anterior_eye0.78855930
118MP0002909_abnormal_adrenal_gland0.78471470
119MP0002938_white_spotting0.78217438
120MP0002111_abnormal_tail_morphology0.77708261
121MP0005076_abnormal_cell_differentiation0.77531271
122MP0001963_abnormal_hearing_physiology0.75698310
123MP0004924_abnormal_behavior0.75487389
124MP0005386_behavior/neurological_phenoty0.75487389
125MP0002733_abnormal_thermal_nociception0.75451143
126MP0001346_abnormal_lacrimal_gland0.75164529
127MP0004197_abnormal_fetal_growth/weight/0.74758959
128MP0001340_abnormal_eyelid_morphology0.73142510
129MP0009672_abnormal_birth_weight0.72333407
130MP0002127_abnormal_cardiovascular_syste0.71566505
131MP0002572_abnormal_emotion/affect_behav0.70490498
132MP0002089_abnormal_postnatal_growth/wei0.70237010
133MP0004085_abnormal_heartbeat0.70018185
134MP0005195_abnormal_posterior_eye0.69475722
135MP0002067_abnormal_sensory_capabilities0.67349961

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)3.31129572
2Mesangial abnormality (HP:0001966)3.27896733
3Nuclear cataract (HP:0100018)2.97425748
4Focal segmental glomerulosclerosis (HP:0000097)2.86041929
5Renal duplication (HP:0000075)2.72328137
6Concave nail (HP:0001598)2.62732476
7Megalencephaly (HP:0001355)2.55883393
8Rib fusion (HP:0000902)2.52025159
9High anterior hairline (HP:0009890)2.50667616
10Zonular cataract (HP:0010920)2.49543784
11Ependymoma (HP:0002888)2.46121243
12Bicornuate uterus (HP:0000813)2.45826646
13Lymphangioma (HP:0100764)2.44845246
14Coronal craniosynostosis (HP:0004440)2.44422525
15Annular pancreas (HP:0001734)2.41488790
16Maternal diabetes (HP:0009800)2.40620465
17Anophthalmia (HP:0000528)2.37282280
18Amblyopia (HP:0000646)2.35910903
19Partial duplication of thumb phalanx (HP:0009944)2.33833573
20Abnormality of the labia minora (HP:0012880)2.32873347
21Hyperacusis (HP:0010780)2.32448234
22Abnormality of the astrocytes (HP:0100707)2.32036686
23Astrocytoma (HP:0009592)2.32036686
24Elfin facies (HP:0004428)2.27994956
25Sleep apnea (HP:0010535)2.26946011
26Exotropia (HP:0000577)2.24434545
27Glomerulosclerosis (HP:0000096)2.22322440
28Hepatoblastoma (HP:0002884)2.16859264
29Shawl scrotum (HP:0000049)2.12906491
30Thin ribs (HP:0000883)2.12441883
31Upper limb amyotrophy (HP:0009129)2.12122947
32Distal upper limb amyotrophy (HP:0007149)2.12122947
33Bronchomalacia (HP:0002780)2.11683460
34Overriding aorta (HP:0002623)2.10090093
35Vertebral arch anomaly (HP:0008438)2.09914111
36Renovascular hypertension (HP:0100817)2.08478638
37Failure to thrive in infancy (HP:0001531)2.06991732
38Insomnia (HP:0100785)2.06157738
39Abnormal number of incisors (HP:0011064)2.04241720
40Ulnar bowing (HP:0003031)2.01018699
41Vitreoretinal degeneration (HP:0000655)1.98570562
42Bilateral microphthalmos (HP:0007633)1.98510249
43Septo-optic dysplasia (HP:0100842)1.97328735
44Shallow orbits (HP:0000586)1.95755675
45Insidious onset (HP:0003587)1.95693283
46Termporal pattern (HP:0011008)1.95693283
47Abnormality of the diencephalon (HP:0010662)1.95272987
48Trigonocephaly (HP:0000243)1.94127968
49Hand muscle atrophy (HP:0009130)1.93638128
50Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93403172
51Short 4th metacarpal (HP:0010044)1.93403172
52Arnold-Chiari malformation (HP:0002308)1.92977688
53Broad metatarsal (HP:0001783)1.92893440
54Partial duplication of the phalanx of hand (HP:0009999)1.92121768
55Back pain (HP:0003418)1.92082682
56Precocious puberty (HP:0000826)1.90117991
57Abnormality of the calcaneus (HP:0008364)1.88409995
58Choanal stenosis (HP:0000452)1.85674069
59Neurofibrillary tangles (HP:0002185)1.81241600
60Abnormality of the 4th metacarpal (HP:0010012)1.81018322
61Cerebral aneurysm (HP:0004944)1.80936938
62Fetal akinesia sequence (HP:0001989)1.79519651
63Vertebral clefting (HP:0008428)1.79397526
64Focal seizures (HP:0007359)1.78765596
65Sex reversal (HP:0012245)1.78393503
66Abnormal sex determination (HP:0012244)1.78393503
67Hammertoe (HP:0001765)1.78242685
68Stage 5 chronic kidney disease (HP:0003774)1.76998548
69Midline defect of the nose (HP:0004122)1.76725271
70Mitral regurgitation (HP:0001653)1.75662244
71Abnormality of the aortic arch (HP:0012303)1.75658319
72Shoulder girdle muscle weakness (HP:0003547)1.74845712
73Esophageal atresia (HP:0002032)1.74395853
74Pseudobulbar signs (HP:0002200)1.74048110
75Neoplasm of the heart (HP:0100544)1.73882661
76Supernumerary spleens (HP:0009799)1.73665984
77Glioma (HP:0009733)1.73241210
78Supranuclear gaze palsy (HP:0000605)1.73135282
79Akinesia (HP:0002304)1.72949605
80Bell-shaped thorax (HP:0001591)1.69391411
81Aqueductal stenosis (HP:0002410)1.69102539
82Cortical dysplasia (HP:0002539)1.67673249
83Increased nuchal translucency (HP:0010880)1.67657588
84Abnormality of the lower motor neuron (HP:0002366)1.67433664
85Reticulocytosis (HP:0001923)1.67356797
86Abnormality of the ischium (HP:0003174)1.66610730
87* Hyperthyroidism (HP:0000836)1.66574431
88Myokymia (HP:0002411)1.66491233
89Pointed chin (HP:0000307)1.63231011
90Epileptic encephalopathy (HP:0200134)1.63047932
91Sudden death (HP:0001699)1.61836939
92Lower limb amyotrophy (HP:0007210)1.61692746
93Spina bifida occulta (HP:0003298)1.61093135
94Abnormality of the parathyroid morphology (HP:0011766)1.60720418
95Oligodactyly (HP:0012165)1.60082466
96Germ cell neoplasia (HP:0100728)1.59734359
97Hypercortisolism (HP:0001578)1.59432475
98Flat cornea (HP:0007720)1.58944618
99Hypercalcemia (HP:0003072)1.58935768
100Action tremor (HP:0002345)1.58755208
101Hypercalciuria (HP:0002150)1.58230665
102Aplasia involving bones of the extremities (HP:0009825)1.58112077
103Aplasia involving bones of the upper limbs (HP:0009823)1.58112077
104Aplasia of the phalanges of the hand (HP:0009802)1.58112077
105Deep palmar crease (HP:0006191)1.57236582
106Ectopic anus (HP:0004397)1.57137778
107Visceral angiomatosis (HP:0100761)1.57123363
108Cutaneous finger syndactyly (HP:0010554)1.57106204
109Calcaneovalgus deformity (HP:0001848)1.56541055
110Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.56388400
111Preaxial foot polydactyly (HP:0001841)1.56165872
112Alacrima (HP:0000522)1.56132710
113Metaphyseal cupping (HP:0003021)1.54986133
114Down-sloping shoulders (HP:0200021)1.54849402
115Facial shape deformation (HP:0011334)1.54094816
116Potter facies (HP:0002009)1.54094816
117Absent hand (HP:0004050)1.53283208
118Hypoplastic ischia (HP:0003175)1.52471020
119Enlarged penis (HP:0000040)1.52315322
120Turricephaly (HP:0000262)1.52287668
121Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.51419357
122Absent epiphyses (HP:0010577)1.51419357
123Agitation (HP:0000713)1.51395065
124Cerebral inclusion bodies (HP:0100314)1.51392825
125Lower limb asymmetry (HP:0100559)1.50951550
126Ankle clonus (HP:0011448)1.50538722
127Broad phalanges of the hand (HP:0009768)1.49926265
128* Bowel incontinence (HP:0002607)1.49514146
129Spastic gait (HP:0002064)1.49495552
130Drooling (HP:0002307)1.48223377
131Excessive salivation (HP:0003781)1.48223377
132Missing ribs (HP:0000921)1.48039797
133Hypoplasia of the brainstem (HP:0002365)1.48004495
134Aplasia/Hypoplasia of the brainstem (HP:0007362)1.48004495
135Broad thumb (HP:0011304)1.47907284
136Rapidly progressive (HP:0003678)1.47725640
137Aplasia/Hypoplasia of the sternum (HP:0006714)1.47708066
138Myopathic facies (HP:0002058)1.47686965
139Long palpebral fissure (HP:0000637)1.47565498
140Depression (HP:0000716)1.46062829
141Stridor (HP:0010307)1.45710399
142Bowel diverticulosis (HP:0005222)1.45388412
143Difficulty climbing stairs (HP:0003551)1.45368707
144Hypoventilation (HP:0002791)1.45334444
145Broad palm (HP:0001169)1.45011680
146Renal hypoplasia (HP:0000089)1.44655099
147Abnormality of the antihelix (HP:0009738)1.44058847
148Congenital malformation of the right heart (HP:0011723)1.44032461
149Double outlet right ventricle (HP:0001719)1.44032461
150* Truncus arteriosus (HP:0001660)1.43842085
151Morphological abnormality of the middle ear (HP:0008609)1.43367300
152Polyphagia (HP:0002591)1.43352699
153Hypoplastic toenails (HP:0001800)1.43330234
154Intellectual disability, moderate (HP:0002342)1.42944841
155Pelvic girdle muscle weakness (HP:0003749)1.42081555
156Sacral dimple (HP:0000960)1.41871039
157Cutaneous syndactyly (HP:0012725)1.40007865
158Morphological abnormality of the pyramidal tract (HP:0002062)1.39986456
159Colon cancer (HP:0003003)1.39977118

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.20347273
2MARK13.99963784
3KSR12.79448832
4PNCK2.33194941
5ICK2.14643091
6NTRK12.05238616
7WNK32.01876340
8NTRK21.92682591
9DYRK21.92219628
10TLK11.78894856
11UHMK11.78595544
12MINK11.72390212
13CAMK1D1.72011572
14LATS21.69291549
15ERBB21.66350596
16MAPK151.65870101
17EPHA41.59676914
18PHKG11.59194943
19PHKG21.59194943
20MAP3K101.48291306
21MAPK131.47655819
22MAP3K91.44252176
23BUB11.42515197
24PAK31.40311176
25BCR1.39691283
26TIE11.36864721
27PAK61.34655357
28WNK41.33826222
29MAP3K41.33339576
30SMG11.33112734
31PDGFRA1.32883758
32CAMKK11.24280082
33TYRO31.21852805
34NEK11.21226046
35PAK41.16830910
36FER1.16059877
37FGFR41.15781307
38DYRK1B1.14694851
39LMTK21.13092220
40PAK21.07528891
41TRIB31.04680576
42ARAF1.04608713
43ROCK11.04403668
44DYRK31.02879245
45INSRR1.00926893
46MAP2K70.99757216
47BMX0.96861605
48MTOR0.92880963
49ROCK20.92550834
50NTRK30.91306768
51PRKD30.91259755
52IRAK20.90970209
53PRKCH0.88957369
54CSNK1G30.88136872
55EPHA20.87302726
56CDK140.85191650
57CDC42BPA0.84477499
58SIK10.83316205
59CDK180.82517804
60EEF2K0.82051384
61PRKCI0.80826612
62AURKA0.80804131
63FGFR20.79485933
64CSNK1A1L0.78654298
65CSNK1G10.78616722
66TTN0.78072175
67CDK150.76671165
68CAMK10.75639847
69OXSR10.74437092
70MAP3K70.73097490
71DMPK0.72868127
72CSNK1G20.71877616
73RPS6KA20.71528404
74MARK20.70306317
75CDK11A0.69418894
76MAP3K60.69349806
77PRKD20.68918204
78AKT20.68197918
79WNK10.67944162
80MAP2K20.67788701
81LIMK10.67087763
82MET0.66859906
83BRAF0.66855561
84MAP3K110.66779449
85CASK0.65543377
86SGK30.65500044
87CSNK1E0.64853800
88STK390.64261254
89EPHA30.63993012
90PTK20.63953128
91PKN20.62991548
92CDK50.62256094
93MAPK90.61865427
94LATS10.61591801
95MAP2K40.60894506
96FGFR10.60807458
97CAMK2B0.60372477
98RPS6KL10.59732065
99RPS6KC10.59732065
100AKT30.58403107
101DDR20.56160148
102ERBB30.55175684
103DAPK20.54491825
104TAOK10.54096916
105PKN10.53889310
106PRKCZ0.53569160
107SGK10.52448610
108STK110.52227464
109ALK0.51927450
110ADRBK10.51479919
111SGK2230.50590475
112SGK4940.50590475
113TESK20.50560558
114SGK20.50331733
115SIK20.49783137
116MAPK100.49607898
117RIPK10.49582793
118RET0.49082497
119GSK3A0.48590947
120PRKCG0.48557478
121DYRK1A0.47938680
122CDK120.47877385
123CAMK2G0.47875804
124MAPK120.47286983
125TNK20.46292411
126RPS6KA60.45587590
127MAP2K10.44558699
128CAMK1G0.44354256
129BRSK10.44121298
130GSK3B0.42729829
131PRKAA10.42014860
132KSR20.41958667
133RPS6KA30.39612835
134MAPK80.39544475
135AKT10.38669273
136TTK0.38435507
137CAMK2D0.38333489
138PTK60.38129923

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.93624978
2Axon guidance_Homo sapiens_hsa043602.92786066
3Hedgehog signaling pathway_Homo sapiens_hsa043402.54140311
4Hippo signaling pathway_Homo sapiens_hsa043902.39655528
5Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.03045676
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88958759
7Notch signaling pathway_Homo sapiens_hsa043301.88483288
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81152089
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.74745177
10Wnt signaling pathway_Homo sapiens_hsa043101.66804723
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63620271
12Gap junction_Homo sapiens_hsa045401.61622014
13Endometrial cancer_Homo sapiens_hsa052131.58948462
14Melanogenesis_Homo sapiens_hsa049161.56351505
15Renal cell carcinoma_Homo sapiens_hsa052111.47718263
16Tight junction_Homo sapiens_hsa045301.45391792
17Glioma_Homo sapiens_hsa052141.37162774
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32862679
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32126061
20mRNA surveillance pathway_Homo sapiens_hsa030151.30655529
21Dorso-ventral axis formation_Homo sapiens_hsa043201.28831690
22Bladder cancer_Homo sapiens_hsa052191.28668023
23Dilated cardiomyopathy_Homo sapiens_hsa054141.28321455
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28211293
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25398948
26Estrogen signaling pathway_Homo sapiens_hsa049151.22029772
27Lysine degradation_Homo sapiens_hsa003101.20064161
28Colorectal cancer_Homo sapiens_hsa052101.19374803
29MicroRNAs in cancer_Homo sapiens_hsa052061.17584835
30Oocyte meiosis_Homo sapiens_hsa041141.16516826
31Morphine addiction_Homo sapiens_hsa050321.15274619
32ErbB signaling pathway_Homo sapiens_hsa040121.15109203
33Butanoate metabolism_Homo sapiens_hsa006501.07820958
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07462308
35Alcoholism_Homo sapiens_hsa050341.06854647
36Thyroid hormone synthesis_Homo sapiens_hsa049181.06274350
37Dopaminergic synapse_Homo sapiens_hsa047281.06243548
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05116625
39Synaptic vesicle cycle_Homo sapiens_hsa047211.05049082
40mTOR signaling pathway_Homo sapiens_hsa041501.04738533
41Nicotine addiction_Homo sapiens_hsa050331.04482944
42Adherens junction_Homo sapiens_hsa045201.03212559
43Focal adhesion_Homo sapiens_hsa045101.03066126
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03062360
45Spliceosome_Homo sapiens_hsa030401.02666311
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02264201
47Long-term depression_Homo sapiens_hsa047300.98989390
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95714452
49ECM-receptor interaction_Homo sapiens_hsa045120.94621807
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.94542141
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94533797
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94363444
53AMPK signaling pathway_Homo sapiens_hsa041520.93483335
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93450745
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92797626
56Cardiac muscle contraction_Homo sapiens_hsa042600.91991720
57Cocaine addiction_Homo sapiens_hsa050300.91753499
58Sulfur relay system_Homo sapiens_hsa041220.91194517
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91052339
60Insulin secretion_Homo sapiens_hsa049110.89269138
61Circadian entrainment_Homo sapiens_hsa047130.89232290
62Insulin signaling pathway_Homo sapiens_hsa049100.88171971
63Proteoglycans in cancer_Homo sapiens_hsa052050.87401070
64Steroid biosynthesis_Homo sapiens_hsa001000.87236947
65Non-small cell lung cancer_Homo sapiens_hsa052230.84735002
66Cholinergic synapse_Homo sapiens_hsa047250.84246061
67Fatty acid biosynthesis_Homo sapiens_hsa000610.82433359
68Melanoma_Homo sapiens_hsa052180.81545912
69Prion diseases_Homo sapiens_hsa050200.80206874
70Pathways in cancer_Homo sapiens_hsa052000.79744821
71GABAergic synapse_Homo sapiens_hsa047270.79472669
72Chronic myeloid leukemia_Homo sapiens_hsa052200.79370180
73GnRH signaling pathway_Homo sapiens_hsa049120.78422831
74Biosynthesis of amino acids_Homo sapiens_hsa012300.78335445
75Oxytocin signaling pathway_Homo sapiens_hsa049210.77883453
76Glucagon signaling pathway_Homo sapiens_hsa049220.76832259
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76524370
78Vitamin B6 metabolism_Homo sapiens_hsa007500.76484426
79Rap1 signaling pathway_Homo sapiens_hsa040150.74751620
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.73780858
81TGF-beta signaling pathway_Homo sapiens_hsa043500.72989409
82Glutamatergic synapse_Homo sapiens_hsa047240.72782400
83Choline metabolism in cancer_Homo sapiens_hsa052310.72300847
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71380694
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71344762
86Olfactory transduction_Homo sapiens_hsa047400.70928474
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70178494
88Gastric acid secretion_Homo sapiens_hsa049710.70058263
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69763264
90Amphetamine addiction_Homo sapiens_hsa050310.69377874
91Arginine and proline metabolism_Homo sapiens_hsa003300.69339111
92Small cell lung cancer_Homo sapiens_hsa052220.68330407
93Inositol phosphate metabolism_Homo sapiens_hsa005620.68288845
94Protein digestion and absorption_Homo sapiens_hsa049740.68149266
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66761194
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.65165942
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64792653
98Prostate cancer_Homo sapiens_hsa052150.63368477
99Long-term potentiation_Homo sapiens_hsa047200.62833580
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62347100
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62335801
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61167051
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.59842207
104Calcium signaling pathway_Homo sapiens_hsa040200.59781600
105Type II diabetes mellitus_Homo sapiens_hsa049300.59585319
106Taste transduction_Homo sapiens_hsa047420.59479208
107Arginine biosynthesis_Homo sapiens_hsa002200.58892796
108MAPK signaling pathway_Homo sapiens_hsa040100.58427017
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57719228
110Fatty acid metabolism_Homo sapiens_hsa012120.57429289
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56300497
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56222271
113Ras signaling pathway_Homo sapiens_hsa040140.54101927
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53057705
115Bile secretion_Homo sapiens_hsa049760.53019512
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52044189
117VEGF signaling pathway_Homo sapiens_hsa043700.51371495
118Renin secretion_Homo sapiens_hsa049240.51301737
119Cell cycle_Homo sapiens_hsa041100.50531697
120Systemic lupus erythematosus_Homo sapiens_hsa053220.50064856
121RNA transport_Homo sapiens_hsa030130.50062601
122cAMP signaling pathway_Homo sapiens_hsa040240.49966730
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48500315
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47297249
125Salivary secretion_Homo sapiens_hsa049700.46706681
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46398453

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