AS3MT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.75978372
2L-phenylalanine catabolic process (GO:0006559)6.75978372
3L-phenylalanine metabolic process (GO:0006558)6.65996555
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.65996555
5aromatic amino acid family catabolic process (GO:0009074)5.63195142
6glyoxylate metabolic process (GO:0046487)5.20070854
7behavioral response to nicotine (GO:0035095)4.94984317
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.70767150
9indole-containing compound catabolic process (GO:0042436)4.65467733
10indolalkylamine catabolic process (GO:0046218)4.65467733
11tryptophan catabolic process (GO:0006569)4.65467733
12alpha-linolenic acid metabolic process (GO:0036109)4.64358824
13lysine metabolic process (GO:0006553)4.50382831
14lysine catabolic process (GO:0006554)4.50382831
15sulfur amino acid catabolic process (GO:0000098)4.50335396
16tryptophan metabolic process (GO:0006568)4.49041249
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.45001369
18bile acid biosynthetic process (GO:0006699)4.43129789
19kynurenine metabolic process (GO:0070189)4.41643647
20cellular ketone body metabolic process (GO:0046950)4.40048214
21cysteine metabolic process (GO:0006534)4.38601387
22aromatic amino acid family metabolic process (GO:0009072)4.28169313
23high-density lipoprotein particle remodeling (GO:0034375)4.14702895
24amino-acid betaine metabolic process (GO:0006577)4.14677350
25tyrosine metabolic process (GO:0006570)4.07797799
26urea cycle (GO:0000050)3.99860382
27urea metabolic process (GO:0019627)3.99860382
28alpha-amino acid catabolic process (GO:1901606)3.97927635
29glucocorticoid biosynthetic process (GO:0006704)3.92045426
30regulation of triglyceride catabolic process (GO:0010896)3.90652483
31valine metabolic process (GO:0006573)3.87925159
32bile acid metabolic process (GO:0008206)3.86902654
33drug transmembrane transport (GO:0006855)3.86666812
34regulation of cholesterol esterification (GO:0010872)3.85423979
35branched-chain amino acid catabolic process (GO:0009083)3.85077098
36fatty acid beta-oxidation (GO:0006635)3.83624492
37cellular amino acid catabolic process (GO:0009063)3.79061525
382-oxoglutarate metabolic process (GO:0006103)3.78653526
39serine family amino acid catabolic process (GO:0009071)3.78274911
40ketone body metabolic process (GO:1902224)3.76164078
41homocysteine metabolic process (GO:0050667)3.74151071
42protein-lipid complex remodeling (GO:0034368)3.73713549
43macromolecular complex remodeling (GO:0034367)3.73713549
44plasma lipoprotein particle remodeling (GO:0034369)3.73713549
45nitrogen cycle metabolic process (GO:0071941)3.72860948
46protein carboxylation (GO:0018214)3.71957894
47peptidyl-glutamic acid carboxylation (GO:0017187)3.71957894
48short-chain fatty acid metabolic process (GO:0046459)3.70056702
49fatty acid oxidation (GO:0019395)3.65999662
50reverse cholesterol transport (GO:0043691)3.65599946
51aldehyde catabolic process (GO:0046185)3.64976227
52branched-chain amino acid metabolic process (GO:0009081)3.62617312
53fatty acid catabolic process (GO:0009062)3.59835605
54lipid oxidation (GO:0034440)3.59162566
55negative regulation of fibrinolysis (GO:0051918)3.57435977
56indolalkylamine metabolic process (GO:0006586)3.57292738
57bile acid and bile salt transport (GO:0015721)3.56566193
58carboxylic acid catabolic process (GO:0046395)3.56255051
59organic acid catabolic process (GO:0016054)3.56255051
60coenzyme catabolic process (GO:0009109)3.55850962
61triglyceride homeostasis (GO:0070328)3.52620825
62acylglycerol homeostasis (GO:0055090)3.52620825
63monocarboxylic acid catabolic process (GO:0072329)3.51671805
64regulation of fibrinolysis (GO:0051917)3.51582155
65low-density lipoprotein particle remodeling (GO:0034374)3.50351879
66L-fucose catabolic process (GO:0042355)3.46562587
67fucose catabolic process (GO:0019317)3.46562587
68L-fucose metabolic process (GO:0042354)3.46562587
69drug catabolic process (GO:0042737)3.45210389
70complement activation, alternative pathway (GO:0006957)3.44708603
71sulfation (GO:0051923)3.43950287
72regulation of protein activation cascade (GO:2000257)3.43132158
73aspartate family amino acid catabolic process (GO:0009068)3.41557808
74carnitine metabolic process (GO:0009437)3.41302227
75estrogen biosynthetic process (GO:0006703)3.40847915
76tricarboxylic acid metabolic process (GO:0072350)3.40457472
77pyrimidine nucleobase catabolic process (GO:0006208)3.37861336
78cellular modified amino acid catabolic process (GO:0042219)3.37725220
79serine family amino acid biosynthetic process (GO:0009070)3.37466912
80benzene-containing compound metabolic process (GO:0042537)3.36997693
81serine family amino acid metabolic process (GO:0009069)3.36384609
82phospholipid efflux (GO:0033700)3.35995670
83cellular biogenic amine catabolic process (GO:0042402)3.34352725
84amine catabolic process (GO:0009310)3.34352725
85drug transport (GO:0015893)3.34064106
86nonmotile primary cilium assembly (GO:0035058)3.32335626
87urate metabolic process (GO:0046415)3.30378061
88arginine metabolic process (GO:0006525)3.29912184
89glycine metabolic process (GO:0006544)3.29441948
90cellular glucuronidation (GO:0052695)3.28661475
91negative regulation of translation, ncRNA-mediated (GO:0040033)3.27793519
92regulation of translation, ncRNA-mediated (GO:0045974)3.27793519
93negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.27793519
94response to mercury ion (GO:0046689)3.26422387
95water-soluble vitamin biosynthetic process (GO:0042364)3.24905136
96androgen biosynthetic process (GO:0006702)3.22805671
97imidazole-containing compound metabolic process (GO:0052803)3.21915100
98ethanol oxidation (GO:0006069)3.21415671
99drug metabolic process (GO:0017144)3.18027466
100negative regulation of sterol transport (GO:0032372)3.16143377
101negative regulation of cholesterol transport (GO:0032375)3.16143377
102flavonoid metabolic process (GO:0009812)3.15855803
103glutamate metabolic process (GO:0006536)3.15649262
104regulation of complement activation (GO:0030449)3.15559068
105pyrimidine nucleoside catabolic process (GO:0046135)3.13510078
106acetyl-CoA metabolic process (GO:0006084)3.11351120
107somite development (GO:0061053)3.08907029
108detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.07423064
109cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.04710772
110fructose metabolic process (GO:0006000)3.04083704
111small molecule catabolic process (GO:0044282)3.03723557
112cholesterol efflux (GO:0033344)3.02075872
113blood coagulation, intrinsic pathway (GO:0007597)3.01306218
114gamma-aminobutyric acid transport (GO:0015812)3.00197004
115alkaloid metabolic process (GO:0009820)3.00105710
116plasma lipoprotein particle clearance (GO:0034381)2.99912718
117epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.99297218
118exogenous drug catabolic process (GO:0042738)2.98912436
119very long-chain fatty acid metabolic process (GO:0000038)2.98743391
120limb bud formation (GO:0060174)2.92411765
121response to pheromone (GO:0019236)2.92208086
122negative regulation of cytosolic calcium ion concentration (GO:0051481)2.85248758
123platelet dense granule organization (GO:0060155)2.80541992
124epithelial cilium movement (GO:0003351)2.79600085
125nucleobase catabolic process (GO:0046113)2.74902707
126behavioral response to ethanol (GO:0048149)2.74222921
127regulation of posttranscriptional gene silencing (GO:0060147)2.70356485
128regulation of gene silencing by miRNA (GO:0060964)2.70356485
129regulation of gene silencing by RNA (GO:0060966)2.70356485
130regulation of nuclear cell cycle DNA replication (GO:0033262)2.69733454
131mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.68106273
132mitochondrial respiratory chain complex I assembly (GO:0032981)2.68106273
133NADH dehydrogenase complex assembly (GO:0010257)2.68106273
134glucocorticoid metabolic process (GO:0008211)2.67948487
135inner ear receptor stereocilium organization (GO:0060122)2.67269642
136transmission of nerve impulse (GO:0019226)2.63564370
137oxidative demethylation (GO:0070989)2.62548982
138kidney morphogenesis (GO:0060993)2.61712104
139replication fork processing (GO:0031297)2.60782102
140nephron tubule morphogenesis (GO:0072078)2.59944617
141nephron epithelium morphogenesis (GO:0072088)2.59944617
1423-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.58328764
143purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.58328764
144C4-dicarboxylate transport (GO:0015740)2.57308363
145negative regulation of transcription regulatory region DNA binding (GO:2000678)2.55972045
146DNA double-strand break processing (GO:0000729)2.55873370
147cornea development in camera-type eye (GO:0061303)2.53243556
148presynaptic membrane assembly (GO:0097105)2.52995923
149retinal ganglion cell axon guidance (GO:0031290)2.51445426
150protein complex biogenesis (GO:0070271)2.49833938
151postsynaptic membrane organization (GO:0001941)2.48801341
152response to follicle-stimulating hormone (GO:0032354)2.47872362
153S-adenosylmethionine metabolic process (GO:0046500)2.47319333
154negative regulation of DNA-dependent DNA replication (GO:2000104)2.46597397
155regulation of mesoderm development (GO:2000380)2.46144808
156mitochondrial respiratory chain complex assembly (GO:0033108)2.45078525
157cellular response to gonadotropin stimulus (GO:0071371)2.44027061
158neural tube formation (GO:0001841)2.43776715
159cilium organization (GO:0044782)2.42388392
160detection of light stimulus involved in visual perception (GO:0050908)2.42039416
161detection of light stimulus involved in sensory perception (GO:0050962)2.42039416
162indole-containing compound metabolic process (GO:0042430)2.39599373
163otic vesicle formation (GO:0030916)2.38059779
164cilium morphogenesis (GO:0060271)2.37648684
165primary amino compound metabolic process (GO:1901160)2.37299123
166regulation of hippo signaling (GO:0035330)2.36878819
167cilium assembly (GO:0042384)2.36213012
168hormone biosynthetic process (GO:0042446)2.35513193
169synaptic transmission, cholinergic (GO:0007271)2.35212267
170auditory receptor cell stereocilium organization (GO:0060088)2.33687909
171atrial cardiac muscle cell action potential (GO:0086014)2.33427912
172regulation of non-canonical Wnt signaling pathway (GO:2000050)2.31807467
173cellular response to sterol (GO:0036315)2.30194262
174neuronal action potential propagation (GO:0019227)2.29913062
175ubiquinone metabolic process (GO:0006743)2.29247748
176regulation of male gonad development (GO:2000018)2.29240942
177cell proliferation in forebrain (GO:0021846)2.28967141
178reciprocal DNA recombination (GO:0035825)2.27936442
179reciprocal meiotic recombination (GO:0007131)2.27936442
180parturition (GO:0007567)2.27529250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.90271196
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.20322255
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.40734133
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.17023287
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.73822278
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.72538872
7LXR_22158963_ChIP-Seq_LIVER_Mouse4.55503883
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.87740441
9ZNF274_21170338_ChIP-Seq_K562_Hela3.73053733
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.66005527
11EZH2_22144423_ChIP-Seq_EOC_Human3.17721086
12VDR_22108803_ChIP-Seq_LS180_Human3.13595918
13GBX2_23144817_ChIP-Seq_PC3_Human3.01183599
14GATA1_22025678_ChIP-Seq_K562_Human2.96813714
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67472110
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.58435486
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49269243
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48965680
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.42535864
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.39416776
21TAF15_26573619_Chip-Seq_HEK293_Human2.34880483
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.32967065
23IGF1R_20145208_ChIP-Seq_DFB_Human2.31597137
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28167178
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25497342
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.21042845
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19559491
28POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18634909
29EWS_26573619_Chip-Seq_HEK293_Human2.16326700
30CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15191197
31FUS_26573619_Chip-Seq_HEK293_Human2.12650326
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.10012694
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05948027
34P300_19829295_ChIP-Seq_ESCs_Human2.05496154
35CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02040416
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.92845272
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.91231708
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88080114
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83172192
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.75827598
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.75796711
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70893477
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.69502478
44BCAT_22108803_ChIP-Seq_LS180_Human1.65604350
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.65416318
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61321725
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.59371302
48ER_23166858_ChIP-Seq_MCF-7_Human1.58947355
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57777596
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57402955
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57402955
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57245559
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56434845
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53107677
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51517194
56TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.51509110
57RNF2_27304074_Chip-Seq_NSC_Mouse1.50788719
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49545167
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49192902
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48648208
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48394878
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48221516
63STAT3_23295773_ChIP-Seq_U87_Human1.46186852
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45811682
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45397471
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.45310532
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.43946386
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43086574
69SMAD4_21799915_ChIP-Seq_A2780_Human1.42497871
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42432688
71AR_25329375_ChIP-Seq_VCAP_Human1.42098409
72MYC_18940864_ChIP-ChIP_HL60_Human1.39978670
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38289207
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36719915
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36456655
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36125745
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34664239
78TCF4_23295773_ChIP-Seq_U87_Human1.33951852
79* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33382032
80REST_21632747_ChIP-Seq_MESCs_Mouse1.33336243
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32678233
82CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32166250
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31868648
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31329794
85TCF4_22108803_ChIP-Seq_LS180_Human1.30418269
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29144167
87* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28609603
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28518683
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27825581
90SOX2_19829295_ChIP-Seq_ESCs_Human1.26190037
91NANOG_19829295_ChIP-Seq_ESCs_Human1.26190037
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25769383
93CBP_20019798_ChIP-Seq_JUKART_Human1.25769383
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25217548
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25146447
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23321625
97HTT_18923047_ChIP-ChIP_STHdh_Human1.22097676
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21609846
99* TP53_22573176_ChIP-Seq_HFKS_Human1.20995595
100ETS1_20019798_ChIP-Seq_JURKAT_Human1.20464104
101RUNX2_22187159_ChIP-Seq_PCA_Human1.20047001
102FOXP3_21729870_ChIP-Seq_TREG_Human1.19838989
103MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19714494
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19677136
105CLOCK_20551151_ChIP-Seq_293T_Human1.19648256
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.19252425
107AR_21572438_ChIP-Seq_LNCaP_Human1.18579951
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17810636
109EZH2_27304074_Chip-Seq_ESCs_Mouse1.17518235
110EZH2_27294783_Chip-Seq_NPCs_Mouse1.17288680
111NFE2_27457419_Chip-Seq_LIVER_Mouse1.16443296
112SCL_19346495_ChIP-Seq_HPC-7_Human1.13883725
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12910338
114FOXA1_25329375_ChIP-Seq_VCAP_Human1.09979770
115FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09979770
116FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09277839
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09043435
118* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08512626
119EED_16625203_ChIP-ChIP_MESCs_Mouse1.07717934
120SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06230904
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05500093
122AR_20517297_ChIP-Seq_VCAP_Human1.05132297
123CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04527957
124* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04222827
125SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03376840
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03115724
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02654971
128NANOG_18555785_Chip-Seq_ESCs_Mouse1.02643169
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.00861488
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00704299
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99519607
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98733935
133DCP1A_22483619_ChIP-Seq_HELA_Human0.98645325
134GATA3_21878914_ChIP-Seq_MCF-7_Human0.98402148
135PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98257948
136LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97638308
137JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97366102
138NOTCH1_21737748_ChIP-Seq_TLL_Human0.96557575
139CRX_20693478_ChIP-Seq_RETINA_Mouse0.95753346
140TP63_19390658_ChIP-ChIP_HaCaT_Human0.95676113
141SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95607846
142* HNF4A_19822575_ChIP-Seq_HepG2_Human0.95593944
143ERG_20517297_ChIP-Seq_VCAP_Human0.94956554
144TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94880327
145ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94647215
146PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94602880
147SOX2_21211035_ChIP-Seq_LN229_Gbm0.94443470
148TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94379641
149* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91993288
150ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91677215
151CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90457649
152GABP_19822575_ChIP-Seq_HepG2_Human0.89243346
153TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88912441
154VDR_23849224_ChIP-Seq_CD4+_Human0.87006233
155GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86322366
156MYC_18555785_ChIP-Seq_MESCs_Mouse0.85167785
157IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.82352156
158IRF1_19129219_ChIP-ChIP_H3396_Human0.82066656
159SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80377969
160ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80190733
161* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79670383
162ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.78835288
163SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78724552
164* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77911158
165BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77823675
166FOXA2_19822575_ChIP-Seq_HepG2_Human0.76899737
167CTCF_18555785_ChIP-Seq_MESCs_Mouse0.74150201
168CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.72484598
169SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72278150
170HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.71577375
171SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70301724
172YY1_21170310_ChIP-Seq_MESCs_Mouse0.70089825
173SOX2_27498859_Chip-Seq_STOMACH_Mouse0.69907779
174THAP11_20581084_ChIP-Seq_MESCs_Mouse0.69634933
175RARA_24833708_ChIP-Seq_LIVER_Mouse0.68501668
176FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.67742493
177TBX5_21415370_ChIP-Seq_HL-1_Mouse0.67532499
178PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.66116913
179MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.65578567
180CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.65135687
181RARB_24833708_ChIP-Seq_LIVER_Mouse0.64872927
182KAP1_22055183_ChIP-Seq_ESCs_Mouse0.63864466
183SOX2_22085726_ChIP-Seq_NPCs_Mouse0.62224549
184* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.61647199
185SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.61469521
186AUTS2_25519132_ChIP-Seq_293T-REX_Human0.61382996
187PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.61204183
188PU.1_20513432_ChIP-Seq_Bcells_Mouse0.60901505
189PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.60408581
190GATA4_25053715_ChIP-Seq_YYC3_Human0.60347998
191GATA3_21867929_ChIP-Seq_CD8_Mouse0.59956776

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.63947923
2MP0005360_urolithiasis6.09846289
3MP0005365_abnormal_bile_salt5.21899913
4MP0005085_abnormal_gallbladder_physiolo5.05029012
5MP0003806_abnormal_nucleotide_metabolis4.17217212
6* MP0008875_abnormal_xenobiotic_pharmacok4.05553378
7MP0009840_abnormal_foam_cell3.01090438
8MP0003195_calcinosis2.96241133
9MP0003252_abnormal_bile_duct2.90268329
10MP0005332_abnormal_amino_acid2.87397242
11MP0010329_abnormal_lipoprotein_level2.79606244
12MP0002102_abnormal_ear_morphology2.69296465
13MP0006292_abnormal_olfactory_placode2.66059462
14MP0001666_abnormal_nutrient_absorption2.37031491
15MP0003122_maternal_imprinting2.27160340
16MP0006036_abnormal_mitochondrial_physio2.25072461
17MP0003191_abnormal_cellular_cholesterol2.22953909
18MP0002938_white_spotting2.20991013
19MP0009697_abnormal_copulation2.15322443
20MP0003136_yellow_coat_color2.12722462
21MP0005083_abnormal_biliary_tract2.12052012
22MP0002837_dystrophic_cardiac_calcinosis2.08773875
23MP0003868_abnormal_feces_composition2.08440505
24MP0001764_abnormal_homeostasis2.06290035
25MP0001984_abnormal_olfaction2.00429382
26MP0002138_abnormal_hepatobiliary_system1.97134336
27MP0004019_abnormal_vitamin_homeostasis1.95127993
28MP0008877_abnormal_DNA_methylation1.93777219
29MP0005319_abnormal_enzyme/_coenzyme1.91126214
30MP0002653_abnormal_ependyma_morphology1.87840504
31MP0009643_abnormal_urine_homeostasis1.85398100
32MP0003880_abnormal_central_pattern1.83753987
33MP0004043_abnormal_pH_regulation1.83716051
34MP0003186_abnormal_redox_activity1.83493618
35MP0002118_abnormal_lipid_homeostasis1.83414763
36MP0000631_abnormal_neuroendocrine_gland1.77855709
37* MP0000609_abnormal_liver_physiology1.76689305
38MP0005253_abnormal_eye_physiology1.71232903
39MP0004133_heterotaxia1.69346678
40MP0006276_abnormal_autonomic_nervous1.68272375
41MP0005584_abnormal_enzyme/coenzyme_acti1.68090264
42MP0001485_abnormal_pinna_reflex1.67912349
43MP0004885_abnormal_endolymph1.63045129
44MP0001293_anophthalmia1.62105196
45MP0001968_abnormal_touch/_nociception1.60527078
46MP0002736_abnormal_nociception_after1.60225315
47MP0003011_delayed_dark_adaptation1.59619675
48MP0003890_abnormal_embryonic-extraembry1.59179720
49MP0001529_abnormal_vocalization1.56133992
50MP0001486_abnormal_startle_reflex1.56034213
51MP0002234_abnormal_pharynx_morphology1.53523520
52MP0003121_genomic_imprinting1.52952833
53MP0009745_abnormal_behavioral_response1.47770685
54MP0005646_abnormal_pituitary_gland1.47714539
55MP0000778_abnormal_nervous_system1.47227960
56MP0004142_abnormal_muscle_tone1.46746708
57MP0005670_abnormal_white_adipose1.46320515
58MP0003937_abnormal_limbs/digits/tail_de1.43390527
59MP0010030_abnormal_orbit_morphology1.39933036
60MP0003787_abnormal_imprinting1.39741994
61MP0009046_muscle_twitch1.37115516
62MP0008995_early_reproductive_senescence1.36739362
63MP0005636_abnormal_mineral_homeostasis1.36435273
64MP0004036_abnormal_muscle_relaxation1.33192365
65MP0003567_abnormal_fetal_cardiomyocyte1.32153530
66MP0005377_hearing/vestibular/ear_phenot1.31972031
67MP0003878_abnormal_ear_physiology1.31972031
68MP0002557_abnormal_social/conspecific_i1.31698810
69MP0004084_abnormal_cardiac_muscle1.30376378
70MP0006035_abnormal_mitochondrial_morpho1.28807769
71MP0002272_abnormal_nervous_system1.27654278
72MP0000566_synostosis1.27200012
73MP0005058_abnormal_lysosome_morphology1.25563038
74MP0002078_abnormal_glucose_homeostasis1.24372224
75MP0005187_abnormal_penis_morphology1.23358110
76MP0005220_abnormal_exocrine_pancreas1.22606774
77MP0004742_abnormal_vestibular_system1.22554104
78MP0003119_abnormal_digestive_system1.21739677
79MP0008872_abnormal_physiological_respon1.16524258
80MP0000427_abnormal_hair_cycle1.16377424
81MP0003718_maternal_effect1.16011725
82MP0000569_abnormal_digit_pigmentation1.15524600
83MP0000647_abnormal_sebaceous_gland1.13600527
84MP0005266_abnormal_metabolism1.11708530
85MP0005195_abnormal_posterior_eye1.11076996
86MP0005084_abnormal_gallbladder_morpholo1.11063442
87MP0001756_abnormal_urination1.10795781
88MP0002160_abnormal_reproductive_system1.10416627
89MP0003137_abnormal_impulse_conducting1.10414305
90MP0003656_abnormal_erythrocyte_physiolo1.10370263
91MP0000598_abnormal_liver_morphology1.08799333
92MP0000049_abnormal_middle_ear1.08504881
93MP0002876_abnormal_thyroid_physiology1.07746969
94MP0002572_abnormal_emotion/affect_behav1.07527976
95MP0005645_abnormal_hypothalamus_physiol1.07176773
96MP0000026_abnormal_inner_ear1.06660676
97MP0000749_muscle_degeneration1.05490110
98MP0000372_irregular_coat_pigmentation1.04622744
99MP0003283_abnormal_digestive_organ1.03934545
100MP0000230_abnormal_systemic_arterial1.03311232
101MP0002064_seizures1.01881344
102MP0005376_homeostasis/metabolism_phenot1.01020148
103MP0005391_vision/eye_phenotype1.00908996
104MP0002233_abnormal_nose_morphology1.00665948
105MP0002254_reproductive_system_inflammat1.00563075
106MP0005386_behavior/neurological_phenoty1.00526300
107MP0004924_abnormal_behavior1.00526300
108MP0005330_cardiomyopathy0.99634303
109MP0008789_abnormal_olfactory_epithelium0.99573730
110MP0004215_abnormal_myocardial_fiber0.99397904
111MP0009642_abnormal_blood_homeostasis0.99226758
112MP0008469_abnormal_protein_level0.99082487
113MP0003938_abnormal_ear_development0.97996251
114MP0004130_abnormal_muscle_cell0.96389002
115MP0002751_abnormal_autonomic_nervous0.96201419
116MP0001286_abnormal_eye_development0.95637767
117MP0001324_abnormal_eye_pigmentation0.95459872
118MP0002752_abnormal_somatic_nervous0.95352465
119MP0005379_endocrine/exocrine_gland_phen0.95167406
120MP0004147_increased_porphyrin_level0.94571958
121MP0002067_abnormal_sensory_capabilities0.93720602
122MP0001661_extended_life_span0.91283889
123MP0001501_abnormal_sleep_pattern0.91188329
124MP0004782_abnormal_surfactant_physiolog0.91130525
125MP0003724_increased_susceptibility_to0.90804263
126MP0010368_abnormal_lymphatic_system0.90377985
127MP0002693_abnormal_pancreas_physiology0.90364159
128MP0005423_abnormal_somatic_nervous0.89438255
129MP0002735_abnormal_chemical_nociception0.89141906
130MP0005389_reproductive_system_phenotype0.88249357
131MP0001944_abnormal_pancreas_morphology0.88016472
132MP0002269_muscular_atrophy0.87644236
133MP0005535_abnormal_body_temperature0.86380713
134MP0009763_increased_sensitivity_to0.84278712
135MP0002063_abnormal_learning/memory/cond0.83718567
136MP0002184_abnormal_innervation0.83408558
137MP0003635_abnormal_synaptic_transmissio0.82290850
138MP0001963_abnormal_hearing_physiology0.82178674
139MP0001986_abnormal_taste_sensitivity0.80317716
140MP0005551_abnormal_eye_electrophysiolog0.78663702
141MP0003646_muscle_fatigue0.77755805
142MP0003183_abnormal_peptide_metabolism0.76943084
143MP0005408_hypopigmentation0.76114578
144MP0004264_abnormal_extraembryonic_tissu0.74931695
145MP0001765_abnormal_ion_homeostasis0.74031054
146MP0002638_abnormal_pupillary_reflex0.72812470
147MP0005451_abnormal_body_composition0.71910598
148MP0003221_abnormal_cardiomyocyte_apopto0.70623386
149MP0000639_abnormal_adrenal_gland0.70335412
150MP0003953_abnormal_hormone_level0.69781450
151MP0009764_decreased_sensitivity_to0.69769826
152MP0005464_abnormal_platelet_physiology0.65628571
153MP0000013_abnormal_adipose_tissue0.63369375
154MP0005647_abnormal_sex_gland0.63025623
155MP0002127_abnormal_cardiovascular_syste0.61895623
156MP0009765_abnormal_xenobiotic_induced0.61371194
157MP0002136_abnormal_kidney_physiology0.60538482
158MP0000747_muscle_weakness0.59061522
159MP0002928_abnormal_bile_duct0.58002801
160MP0005334_abnormal_fat_pad0.57399474
161MP0002972_abnormal_cardiac_muscle0.55035425
162MP0002909_abnormal_adrenal_gland0.54981301
163MP0004145_abnormal_muscle_electrophysio0.54959382
164MP0005385_cardiovascular_system_phenoty0.54414153
165MP0001544_abnormal_cardiovascular_syste0.54414153
166MP0005620_abnormal_muscle_contractility0.53100460
167MP0003638_abnormal_response/metabolism_0.52952906
168MP0001853_heart_inflammation0.52928655
169MP0002090_abnormal_vision0.52352462
170MP0006072_abnormal_retinal_apoptosis0.52079993
171MP0008873_increased_physiological_sensi0.52032911
172MP0005448_abnormal_energy_balance0.51884181
173MP0008775_abnormal_heart_ventricle0.51773484
174MP0002971_abnormal_brown_adipose0.50726828
175MP0003690_abnormal_glial_cell0.50527421
176MP0003950_abnormal_plasma_membrane0.48995141

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.48696055
2Intrahepatic cholestasis (HP:0001406)4.95762924
3Hypoglycemic coma (HP:0001325)4.87281323
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.67073144
5Prolonged partial thromboplastin time (HP:0003645)4.35749910
6Hypobetalipoproteinemia (HP:0003563)4.33300628
7Ketosis (HP:0001946)4.23115402
8Xanthomatosis (HP:0000991)4.13562360
9Ketoacidosis (HP:0001993)3.99099255
10Hyperammonemia (HP:0001987)3.98200864
11Deep venous thrombosis (HP:0002625)3.95280678
12Pancreatic cysts (HP:0001737)3.92272600
13Abnormality of fatty-acid metabolism (HP:0004359)3.88550513
14Hyperlipoproteinemia (HP:0010980)3.86849207
15True hermaphroditism (HP:0010459)3.86300803
16Molar tooth sign on MRI (HP:0002419)3.84817992
17Abnormality of midbrain morphology (HP:0002418)3.84817992
18Generalized aminoaciduria (HP:0002909)3.83433355
19Pancreatic fibrosis (HP:0100732)3.69200113
20Hypoglycemic seizures (HP:0002173)3.68868321
21Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.57891829
22Nephronophthisis (HP:0000090)3.55090612
23Abnormality of dicarboxylic acid metabolism (HP:0010995)3.49333021
24Dicarboxylic aciduria (HP:0003215)3.49333021
25Hepatic necrosis (HP:0002605)3.42543532
26Hyperglycinuria (HP:0003108)3.41298685
27Abnormality of glycine metabolism (HP:0010895)3.32149721
28Abnormality of serine family amino acid metabolism (HP:0010894)3.32149721
29Hyperglycinemia (HP:0002154)3.28275718
30Cerebral edema (HP:0002181)3.27153697
31Abnormality of aspartate family amino acid metabolism (HP:0010899)3.26669364
32Abnormality of the intrinsic pathway (HP:0010989)3.22761697
33Hyperinsulinemic hypoglycemia (HP:0000825)3.20898879
34Hypolipoproteinemia (HP:0010981)3.20107090
35Abnormality of the common coagulation pathway (HP:0010990)3.13990832
36Late onset (HP:0003584)3.13986210
37Abnormality of methionine metabolism (HP:0010901)3.13741586
38Symptomatic seizures (HP:0011145)3.05378687
39Abnormality of the renal medulla (HP:0100957)3.04175569
40Joint hemorrhage (HP:0005261)3.02631468
41Fat malabsorption (HP:0002630)3.02476382
42Abnormality of glutamine family amino acid metabolism (HP:0010902)3.00068746
43Lethargy (HP:0001254)2.98965193
44Congenital stationary night blindness (HP:0007642)2.97886794
45Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.97031683
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.96122786
47Abnormality of alanine metabolism (HP:0010916)2.96122786
48Hyperalaninemia (HP:0003348)2.96122786
49Acute encephalopathy (HP:0006846)2.95814882
50Abnormality of sulfur amino acid metabolism (HP:0004339)2.95091235
51Type II lissencephaly (HP:0007260)2.94835033
52Metabolic acidosis (HP:0001942)2.93184817
53Conjugated hyperbilirubinemia (HP:0002908)2.91692391
54Hyperbilirubinemia (HP:0002904)2.91442197
55Medial flaring of the eyebrow (HP:0010747)2.90726215
56Abnormality of urine glucose concentration (HP:0011016)2.82430363
57Glycosuria (HP:0003076)2.82430363
58Proximal tubulopathy (HP:0000114)2.82103561
59Abnormality of the renal cortex (HP:0011035)2.80261109
60Hepatocellular necrosis (HP:0001404)2.77330457
61Hyperventilation (HP:0002883)2.72856072
62Gout (HP:0001997)2.71442402
63Complement deficiency (HP:0004431)2.70594092
64Myoglobinuria (HP:0002913)2.69764234
65Hypoalphalipoproteinemia (HP:0003233)2.66690303
66Chronic hepatic failure (HP:0100626)2.66632427
67Abnormality of serum amino acid levels (HP:0003112)2.66244624
68Abnormal mitochondria in muscle tissue (HP:0008316)2.61228174
69Abnormality of pyrimidine metabolism (HP:0004353)2.60859714
70Delayed CNS myelination (HP:0002188)2.57732968
71Concave nail (HP:0001598)2.54620094
72Abnormality of nucleobase metabolism (HP:0010932)2.52416926
73Male pseudohermaphroditism (HP:0000037)2.52221478
74Epidermoid cyst (HP:0200040)2.51241988
75Acute necrotizing encephalopathy (HP:0006965)2.50808837
76Increased muscle lipid content (HP:0009058)2.49036797
77Colon cancer (HP:0003003)2.48819787
78Abnormality of purine metabolism (HP:0004352)2.48195532
79Decreased circulating renin level (HP:0003351)2.47018488
80Abnormality of the pancreatic islet cells (HP:0006476)2.45030366
81Abnormality of endocrine pancreas physiology (HP:0012093)2.45030366
82Mitochondrial inheritance (HP:0001427)2.44989672
83Abnormality of the labia minora (HP:0012880)2.44196670
84Cystic liver disease (HP:0006706)2.43638689
85Tubular atrophy (HP:0000092)2.43334594
86Hypercholesterolemia (HP:0003124)2.42523506
87Birth length less than 3rd percentile (HP:0003561)2.41364055
88Palpitations (HP:0001962)2.40432996
89Vomiting (HP:0002013)2.38006212
90Gait imbalance (HP:0002141)2.37910417
91Genital tract atresia (HP:0001827)2.37490899
92Inability to walk (HP:0002540)2.36565447
93Vaginal atresia (HP:0000148)2.34609794
94Increased CSF lactate (HP:0002490)2.32930822
95Congenital primary aphakia (HP:0007707)2.32716907
96Pancreatic islet-cell hyperplasia (HP:0004510)2.32681550
97Lactic acidosis (HP:0003128)2.31975315
98Lipid accumulation in hepatocytes (HP:0006561)2.31551831
99Abnormal biliary tract physiology (HP:0012439)2.30817074
100Bile duct proliferation (HP:0001408)2.30817074
101Pendular nystagmus (HP:0012043)2.29647076
102Steatorrhea (HP:0002570)2.28315923
103Anophthalmia (HP:0000528)2.24884574
104Sclerocornea (HP:0000647)2.24474136
105Irritability (HP:0000737)2.24473019
106Increased intramyocellular lipid droplets (HP:0012240)2.24443434
107Renal salt wasting (HP:0000127)2.22009401
108Abolished electroretinogram (ERG) (HP:0000550)2.20437234
109Ragged-red muscle fibers (HP:0003200)2.18338421
110Septo-optic dysplasia (HP:0100842)2.18174084
111Patellar aplasia (HP:0006443)2.17922409
112Nephrogenic diabetes insipidus (HP:0009806)2.17886603
113Renal Fanconi syndrome (HP:0001994)2.17749659
114Attenuation of retinal blood vessels (HP:0007843)2.16895195
115Cerebral palsy (HP:0100021)2.15754035
116Rhabdomyolysis (HP:0003201)2.14331247
117Skin nodule (HP:0200036)2.13900416
118Hyperphosphaturia (HP:0003109)2.13733169
119Methylmalonic aciduria (HP:0012120)2.13185892
120Opisthotonus (HP:0002179)2.12445762
121Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12006999
122Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12006999
123Anencephaly (HP:0002323)2.11172374
124Optic nerve hypoplasia (HP:0000609)2.10603295
125Alkalosis (HP:0001948)2.09862383
126Aplasia/Hypoplasia of the tongue (HP:0010295)2.09441471
127Lissencephaly (HP:0001339)2.09014541
128Supernumerary spleens (HP:0009799)2.08720180
129Brushfield spots (HP:0001088)2.08299895
130Renal cortical cysts (HP:0000803)2.08128637
131Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07590016
132Increased serum pyruvate (HP:0003542)2.07485406
133Abnormality of glycolysis (HP:0004366)2.07485406
134Cerebellar dysplasia (HP:0007033)2.07338164
135Progressive macrocephaly (HP:0004481)2.04440114
136Enlarged kidneys (HP:0000105)2.04438473
137Congenital hepatic fibrosis (HP:0002612)2.03521942
138Aplasia/Hypoplasia of the patella (HP:0006498)2.02790954
139Large for gestational age (HP:0001520)2.01893473
140Intestinal atresia (HP:0011100)2.01196161
141Hyperglycemia (HP:0003074)2.00983958
142Pancreatitis (HP:0001733)2.00096380
143Nausea (HP:0002018)1.98878019
144Increased serum lactate (HP:0002151)1.93647821
145Bilateral microphthalmos (HP:0007633)1.93456395
146Abnormal gallbladder morphology (HP:0012437)1.93090989
147Reduced antithrombin III activity (HP:0001976)1.92704188
148Dandy-Walker malformation (HP:0001305)1.91741026
149Postaxial foot polydactyly (HP:0001830)1.91331059
150CNS demyelination (HP:0007305)1.90847239
151Methylmalonic acidemia (HP:0002912)1.89884452
152Hepatocellular carcinoma (HP:0001402)1.89438063
153Arthropathy (HP:0003040)1.88919092
154Elevated hepatic transaminases (HP:0002910)1.88414589
155Increased corneal curvature (HP:0100692)1.87361834
156Keratoconus (HP:0000563)1.87361834
157Broad-based gait (HP:0002136)1.86780829
158Polydipsia (HP:0001959)1.86726267
159Abnormal drinking behavior (HP:0030082)1.86726267
160Partial agenesis of the corpus callosum (HP:0001338)1.86482171
161Hyperaldosteronism (HP:0000859)1.86351143
162Postaxial hand polydactyly (HP:0001162)1.84912665
163Aplasia/Hypoplasia of the uvula (HP:0010293)1.83695967
164Abnormality of the pons (HP:0007361)1.83309087
165Cholelithiasis (HP:0001081)1.82293856
166Scrotal hypoplasia (HP:0000046)1.82030096
167Abnormality of vitamin metabolism (HP:0100508)1.81525682
168Furrowed tongue (HP:0000221)1.80240843
169Abnormality of the ileum (HP:0001549)1.80090209
170Poor coordination (HP:0002370)1.79404476
171Congenital, generalized hypertrichosis (HP:0004540)1.78734009
172Decreased central vision (HP:0007663)1.77507031
173Chorioretinal atrophy (HP:0000533)1.77364991
174Aplasia/Hypoplasia of the tibia (HP:0005772)1.77102754
175Enlarged penis (HP:0000040)1.75678345
176Dynein arm defect of respiratory motile cilia (HP:0012255)1.75044816
177Absent/shortened dynein arms (HP:0200106)1.75044816
178Occipital encephalocele (HP:0002085)1.74377915
179Progressive inability to walk (HP:0002505)1.73660767
180Meckel diverticulum (HP:0002245)1.72457785
181Hypoplasia of the pons (HP:0012110)1.71956940
182Aplasia/hypoplasia of the uterus (HP:0008684)1.71286848
183Focal motor seizures (HP:0011153)1.71131041
184Preaxial hand polydactyly (HP:0001177)1.67175388
185Severe muscular hypotonia (HP:0006829)1.66734228
186Abnormal rod and cone electroretinograms (HP:0008323)1.66246762
187Gaze-evoked nystagmus (HP:0000640)1.65811409
188Hypoplasia of the uterus (HP:0000013)1.64786495
189Drooling (HP:0002307)1.64763290
190Pachygyria (HP:0001302)1.63632732
191Polyuria (HP:0000103)1.63356808
192Oligodactyly (hands) (HP:0001180)1.61398022

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.38867057
2STK163.75166841
3FLT33.43863395
4INSRR3.18514745
5TIE12.94081260
6ZAK2.84318600
7ERN12.82916285
8TAOK32.47518223
9MAP4K22.43676690
10CASK2.41882005
11PIK3CG2.37522698
12NUAK12.24524085
13OBSCN2.24025906
14MKNK22.10608706
15MAPK152.09619367
16PASK2.03598246
17MYLK1.95308630
18FRK1.77399524
19MAP3K41.69924306
20FGFR41.69341805
21TEC1.67490733
22TLK11.64223945
23KDR1.59045265
24TGFBR11.56946097
25MAPK131.54807495
26MAP2K31.54564882
27PNCK1.53768084
28MKNK11.53559422
29EIF2AK31.50355746
30PINK11.46847537
31BRSK21.46660508
32DYRK21.45973637
33EPHA41.43780769
34WNK31.40802052
35MAP2K61.37864855
36NME21.36206880
37KIT1.36046371
38FGFR21.35053197
39MARK11.33444020
40PLK41.31176787
41WNK41.28432781
42BTK1.26919584
43PHKG11.22341171
44PHKG21.22341171
45TAF11.20366035
46PLK31.19526028
47STK38L1.19119658
48NEK11.18374019
49OXSR11.16772356
50PRKCG1.15008062
51NEK21.12409498
52PRKAA21.10565434
53PRKG21.06650351
54TRIM281.06483155
55STK391.05736518
56MAPK111.05542423
57BCR1.04710251
58PKN21.02934289
59VRK21.01544828
60NTRK21.00501847
61TYK20.99468117
62ADRBK10.99136257
63ZAP700.98887943
64PDK40.96968576
65PDK30.96968576
66AKT30.96270437
67NTRK30.96131530
68ACVR1B0.93907339
69MAP2K70.92191812
70IRAK30.91949677
71PLK20.91802820
72CSNK1G20.88526706
73BMPR1B0.88195249
74MUSK0.87409245
75CAMKK20.85625584
76TAOK20.85403589
77TGFBR20.84877851
78LMTK20.84123053
79CSNK1G10.83150560
80PRKCE0.82982689
81SIK10.82315805
82STK30.77290730
83NEK90.77172907
84HIPK20.75456440
85DAPK20.73539598
86TBK10.72220212
87VRK10.70920856
88ITK0.70899496
89PRKAA10.69670075
90MAP2K20.68709443
91IRAK40.67216437
92MAP3K30.67108778
93LATS10.66569841
94IRAK10.65916775
95MAP3K110.65466904
96PLK10.64906398
97JAK30.64390592
98CDC70.63889044
99CSNK1G30.62616117
100CAMK2A0.60542322
101STK110.60344651
102GRK10.60011472
103CDK80.58731001
104EIF2AK10.58609110
105NLK0.58293854
106ADRBK20.57816111
107PDK20.57751756
108PIK3CA0.57495498
109PKN10.55199990
110NME10.54464191
111MAP4K10.53344621
112CSF1R0.53066134
113MAP3K10.52531720
114DYRK30.52282651
115CSNK1A1L0.51226939
116ABL20.51139500
117CAMK2G0.50558072
118MAPK40.50484517
119IRAK20.49937687
120TTK0.49840837
121MAPKAPK50.49776829
122MATK0.49317807
123JAK20.48434226
124DYRK1A0.47937015
125CDK30.47390800
126PRKACG0.46785579
127BRAF0.46632594
128CAMK10.45936260
129MAP3K120.45520519
130EPHA30.44788007
131PAK30.44547043
132PTK60.44349813
133ERBB30.43504240
134CSNK1D0.42265095
135CAMK2D0.41917207
136BUB10.41774233
137EPHB20.41693870
138CSNK1A10.41484177
139DYRK1B0.41025636
140GRK70.39585636
141FGFR10.37789860
142MAPK120.37772802
143PRKG10.37714693
144ATR0.37645308
145CSNK1E0.37403369
146MAP2K40.37131308
147TNIK0.37083242
148RPS6KA50.36939187
149MET0.34901957
150PBK0.34383374
151PRKACA0.34382013
152TSSK60.34083727
153PRKCZ0.33863399
154IGF1R0.33505969
155EPHB10.33478477
156ATM0.33360138
157CCNB10.33189063
158ERBB20.32899944
159WEE10.32160051
160RPS6KA60.32033660
161SYK0.31556924
162PTK2B0.31097037
163TYRO30.29940612
164MINK10.29458935

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.22859940
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.80652875
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.76359205
4Fatty acid degradation_Homo sapiens_hsa000712.64870586
5Tryptophan metabolism_Homo sapiens_hsa003802.52608579
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47467553
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45465621
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.43090194
9Propanoate metabolism_Homo sapiens_hsa006402.42260593
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.38054373
11Nitrogen metabolism_Homo sapiens_hsa009102.37632512
12Arginine biosynthesis_Homo sapiens_hsa002202.27200820
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.22420843
14Sulfur metabolism_Homo sapiens_hsa009202.18804658
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.16294612
16Butanoate metabolism_Homo sapiens_hsa006502.14610267
17Peroxisome_Homo sapiens_hsa041462.14328470
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.07465073
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05647585
20Phototransduction_Homo sapiens_hsa047441.92191557
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90178669
22Folate biosynthesis_Homo sapiens_hsa007901.88564950
23Fatty acid metabolism_Homo sapiens_hsa012121.86188555
24Histidine metabolism_Homo sapiens_hsa003401.79748487
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.78585106
26Fatty acid elongation_Homo sapiens_hsa000621.78472597
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74027903
28Complement and coagulation cascades_Homo sapiens_hsa046101.72781554
29Pyruvate metabolism_Homo sapiens_hsa006201.68638598
30Protein export_Homo sapiens_hsa030601.63164275
31beta-Alanine metabolism_Homo sapiens_hsa004101.62724309
32Nicotine addiction_Homo sapiens_hsa050331.61120715
33Homologous recombination_Homo sapiens_hsa034401.60626957
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.60028911
35Carbon metabolism_Homo sapiens_hsa012001.56530920
36Selenocompound metabolism_Homo sapiens_hsa004501.56374975
37PPAR signaling pathway_Homo sapiens_hsa033201.53992777
38Starch and sucrose metabolism_Homo sapiens_hsa005001.53386267
39Chemical carcinogenesis_Homo sapiens_hsa052041.49792234
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47240507
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46086195
42Ovarian steroidogenesis_Homo sapiens_hsa049131.44197925
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.42282793
44Fanconi anemia pathway_Homo sapiens_hsa034601.40600213
45Phenylalanine metabolism_Homo sapiens_hsa003601.35977194
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35969890
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34693378
48Biosynthesis of amino acids_Homo sapiens_hsa012301.33009586
49Basal transcription factors_Homo sapiens_hsa030221.30150730
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26577963
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.25082225
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.22555415
53Tyrosine metabolism_Homo sapiens_hsa003501.21704346
54Retinol metabolism_Homo sapiens_hsa008301.19279540
55Sulfur relay system_Homo sapiens_hsa041221.16201646
56Caffeine metabolism_Homo sapiens_hsa002321.15106536
57Arginine and proline metabolism_Homo sapiens_hsa003301.14579248
58Oxidative phosphorylation_Homo sapiens_hsa001901.12432672
59Ether lipid metabolism_Homo sapiens_hsa005651.12288616
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11483360
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10179955
62Parkinsons disease_Homo sapiens_hsa050121.06949013
63ABC transporters_Homo sapiens_hsa020101.06572597
64Pentose phosphate pathway_Homo sapiens_hsa000301.03225306
65RNA polymerase_Homo sapiens_hsa030201.00269709
66Bile secretion_Homo sapiens_hsa049760.99695495
67Galactose metabolism_Homo sapiens_hsa000520.99096785
68Fat digestion and absorption_Homo sapiens_hsa049750.97249176
69Vitamin digestion and absorption_Homo sapiens_hsa049770.97160722
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96625402
71Taste transduction_Homo sapiens_hsa047420.95157574
72RNA degradation_Homo sapiens_hsa030180.94050375
73Glutathione metabolism_Homo sapiens_hsa004800.92586194
74Morphine addiction_Homo sapiens_hsa050320.89801505
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87272924
76Fructose and mannose metabolism_Homo sapiens_hsa000510.86020223
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84915655
78Basal cell carcinoma_Homo sapiens_hsa052170.84547396
79Staphylococcus aureus infection_Homo sapiens_hsa051500.83287852
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80862375
81Metabolic pathways_Homo sapiens_hsa011000.78207665
82Steroid biosynthesis_Homo sapiens_hsa001000.76970160
83GABAergic synapse_Homo sapiens_hsa047270.76918646
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76533740
85Glutamatergic synapse_Homo sapiens_hsa047240.75118682
86Hedgehog signaling pathway_Homo sapiens_hsa043400.73586209
87Circadian entrainment_Homo sapiens_hsa047130.72121319
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71037968
89Serotonergic synapse_Homo sapiens_hsa047260.68804452
90Other glycan degradation_Homo sapiens_hsa005110.65556233
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61802684
92Olfactory transduction_Homo sapiens_hsa047400.60549652
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59773950
94Alzheimers disease_Homo sapiens_hsa050100.59555686
95Insulin secretion_Homo sapiens_hsa049110.59215692
96Proteasome_Homo sapiens_hsa030500.58598555
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56252460
98Lysine degradation_Homo sapiens_hsa003100.52303247
99One carbon pool by folate_Homo sapiens_hsa006700.51639986
100Glycerolipid metabolism_Homo sapiens_hsa005610.49960225
101Vitamin B6 metabolism_Homo sapiens_hsa007500.48566072
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46048598
103Huntingtons disease_Homo sapiens_hsa050160.44845485
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44262044
105Hippo signaling pathway_Homo sapiens_hsa043900.42800913
106Nucleotide excision repair_Homo sapiens_hsa034200.41885207
107Fatty acid biosynthesis_Homo sapiens_hsa000610.40824905
108Calcium signaling pathway_Homo sapiens_hsa040200.40655588
109Circadian rhythm_Homo sapiens_hsa047100.40583887
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37332136
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.35802107
112Cardiac muscle contraction_Homo sapiens_hsa042600.35240169
113Regulation of autophagy_Homo sapiens_hsa041400.33999796
114Pyrimidine metabolism_Homo sapiens_hsa002400.33453700
115N-Glycan biosynthesis_Homo sapiens_hsa005100.31704727
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31425763
117Linoleic acid metabolism_Homo sapiens_hsa005910.28317244
118Arachidonic acid metabolism_Homo sapiens_hsa005900.23935229
119Insulin resistance_Homo sapiens_hsa049310.20185103
120Ribosome_Homo sapiens_hsa030100.19386514
121Glucagon signaling pathway_Homo sapiens_hsa049220.16845448
122Purine metabolism_Homo sapiens_hsa002300.16796443
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14940475
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.12168401
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.11717290
126Lysosome_Homo sapiens_hsa041420.11673490
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.09079717
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07817101
129Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.05818600
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.04025658

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