ASAH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. Processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene are associated with the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.74105554
2COPI coating of Golgi vesicle (GO:0048205)5.74105554
3modulation by symbiont of host immune response (GO:0052553)5.50307446
4positive regulation by symbiont of host defense response (GO:0052509)5.50307446
5modulation by symbiont of host defense response (GO:0052031)5.50307446
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.50307446
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.50307446
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.50307446
9neutrophil activation involved in immune response (GO:0002283)5.26896518
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.19564256
11regulation of interferon-beta biosynthetic process (GO:0045357)5.02474825
12microglial cell activation (GO:0001774)4.70511987
13macrophage activation involved in immune response (GO:0002281)4.42640737
14keratan sulfate catabolic process (GO:0042340)4.31717372
15signal peptide processing (GO:0006465)4.20545717
16oligosaccharide catabolic process (GO:0009313)4.12197200
17positive regulation of monocyte chemotaxis (GO:0090026)4.02133936
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.91160096
19production of molecular mediator involved in inflammatory response (GO:0002532)3.85532704
20positive regulation of interferon-alpha production (GO:0032727)3.85192016
21amino sugar catabolic process (GO:0046348)3.80928546
22negative regulation of interleukin-12 production (GO:0032695)3.79507766
23regulation of monocyte chemotaxis (GO:0090025)3.72802025
24regulation of integrin-mediated signaling pathway (GO:2001044)3.72448657
25phagocytosis, engulfment (GO:0006911)3.71554386
26negative regulation of mast cell activation (GO:0033004)3.67064421
27response to thyroid hormone (GO:0097066)3.60463981
28regulation of interferon-alpha production (GO:0032647)3.60026309
29macrophage activation (GO:0042116)3.56420274
30positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.55715257
31apoptotic cell clearance (GO:0043277)3.55646754
32response to peptidoglycan (GO:0032494)3.53387187
33positive regulation of mast cell activation (GO:0033005)3.50386115
34glycosphingolipid catabolic process (GO:0046479)3.47671246
35protein retention in ER lumen (GO:0006621)3.47625788
36positive regulation of gamma-delta T cell activation (GO:0046645)3.47472512
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.44360118
38response to host immune response (GO:0052572)3.44360118
39regulation of cholesterol storage (GO:0010885)3.42127138
40pinocytosis (GO:0006907)3.41121947
41cellular extravasation (GO:0045123)3.40532431
42detection of other organism (GO:0098543)3.40213321
43cell adhesion mediated by integrin (GO:0033627)3.37759628
44detection of molecule of bacterial origin (GO:0032490)3.27408600
45N-acetylneuraminate metabolic process (GO:0006054)3.26112233
46respiratory burst (GO:0045730)3.25997538
47detection of external biotic stimulus (GO:0098581)3.24902319
48wound healing, spreading of epidermal cells (GO:0035313)3.22546498
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.21336822
50response to host (GO:0075136)3.21336822
51response to host defenses (GO:0052200)3.21336822
52positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.19429115
53positive regulation of mast cell activation involved in immune response (GO:0033008)3.17106277
54positive regulation of mast cell degranulation (GO:0043306)3.17106277
55glycolipid catabolic process (GO:0019377)3.16785982
56retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.16538709
57hyaluronan catabolic process (GO:0030214)3.07125385
58positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.03186183
59response to lipoprotein particle (GO:0055094)3.02268622
60peptide catabolic process (GO:0043171)3.01684625
61sequestering of metal ion (GO:0051238)3.00662236
62positive regulation of cellular amide metabolic process (GO:0034250)2.98629797
63G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.96771194
64negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.95896006
65neutrophil activation (GO:0042119)2.94460075
66immunoglobulin mediated immune response (GO:0016064)2.94214973
67negative regulation of cell killing (GO:0031342)2.92404308
68negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.92404308
69cellular response to thyroid hormone stimulus (GO:0097067)2.91209876
70regulation of mononuclear cell migration (GO:0071675)2.90881786
71granulocyte activation (GO:0036230)2.88789060
72detection of bacterium (GO:0016045)2.86807474
73regulation of dendritic cell antigen processing and presentation (GO:0002604)2.85851708
74positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.84685286
75ceramide catabolic process (GO:0046514)2.84483997
76detection of biotic stimulus (GO:0009595)2.82358058
77cellular response to vitamin (GO:0071295)2.82152714
78positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.81878853
79cellular response to vitamin D (GO:0071305)2.81200677
80myeloid cell activation involved in immune response (GO:0002275)2.80669533
81melanin biosynthetic process (GO:0042438)2.80473733
82positive regulation of receptor recycling (GO:0001921)2.80460088
83basement membrane organization (GO:0071711)2.78503142
84eosinophil chemotaxis (GO:0048245)2.77397579
85wound healing, spreading of cells (GO:0044319)2.73506003
86adhesion of symbiont to host cell (GO:0044650)2.73407423
87virion attachment to host cell (GO:0019062)2.73407423
88positive regulation of interferon-beta production (GO:0032728)2.72750335
89positive regulation of antigen processing and presentation (GO:0002579)2.72387859
90positive regulation of macrophage cytokine production (GO:0060907)2.70705105
91positive regulation of cholesterol efflux (GO:0010875)2.68448436
92regulation of antigen processing and presentation (GO:0002577)2.68350778
93regulation of myeloid leukocyte mediated immunity (GO:0002886)2.66727568
94negative regulation of interleukin-1 beta production (GO:0032691)2.65546221
95positive regulation of leukocyte degranulation (GO:0043302)2.64877900
96positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.64333665
97regulation of mast cell activation involved in immune response (GO:0033006)2.60355756
98regulation of gamma-delta T cell activation (GO:0046643)2.60097564
99intracellular pH reduction (GO:0051452)2.59973911
100positive regulation of chemokine secretion (GO:0090197)2.59352671
101antigen processing and presentation of endogenous antigen (GO:0019883)2.59338612
102cellular response to interferon-alpha (GO:0035457)2.58849946
103antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.58830831
104regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.58480859
105negative regulation of lipid storage (GO:0010888)2.58291528
106hydrogen peroxide biosynthetic process (GO:0050665)2.57250278
107melanin metabolic process (GO:0006582)2.56923607
108regulation of mast cell activation (GO:0033003)2.56746321
109endodermal cell differentiation (GO:0035987)2.56225265
110regulation of macrophage derived foam cell differentiation (GO:0010743)2.55750829
111lysosome organization (GO:0007040)2.55366551
112lytic vacuole organization (GO:0080171)2.55366551
113regulation of macrophage cytokine production (GO:0010935)2.54591009
114pH reduction (GO:0045851)2.54547395
115superoxide anion generation (GO:0042554)2.54398298
116low-density lipoprotein particle clearance (GO:0034383)2.52386818
117collagen fibril organization (GO:0030199)2.51956510
118phagosome maturation (GO:0090382)2.51600131
119activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.51499765
120positive regulation of cholesterol transport (GO:0032376)2.51466506
121positive regulation of sterol transport (GO:0032373)2.51466506
122regulation of mast cell degranulation (GO:0043304)2.51163444
123regulation of macrophage chemotaxis (GO:0010758)2.50922690
124membrane lipid catabolic process (GO:0046466)2.50769912
125low-density lipoprotein particle remodeling (GO:0034374)2.50535133
126adhesion of symbiont to host (GO:0044406)2.50002551
127T-helper 1 type immune response (GO:0042088)2.49706125
128membrane invagination (GO:0010324)2.49570994
129regulation of metalloenzyme activity (GO:0048552)2.48523510
130sphingolipid catabolic process (GO:0030149)2.48153658
131I-kappaB phosphorylation (GO:0007252)2.47059101
132endoplasmic reticulum unfolded protein response (GO:0030968)2.46905242
133positive regulation of chemokine production (GO:0032722)2.46304663
134regulation of leukocyte degranulation (GO:0043300)2.45815481
135eosinophil migration (GO:0072677)2.44630469
136protein maturation by protein folding (GO:0022417)2.44186018
137interferon-gamma-mediated signaling pathway (GO:0060333)2.43955487
138regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.43849476
139regulation of B cell receptor signaling pathway (GO:0050855)2.43448029
140regulation of beta-amyloid formation (GO:1902003)2.42740491
141cellular response to unfolded protein (GO:0034620)2.42584413
142regulation of superoxide anion generation (GO:0032928)2.42445916
143positive regulation of SMAD protein import into nucleus (GO:0060391)2.42142679
144negative regulation of interleukin-1 production (GO:0032692)2.42068317
145lipopolysaccharide-mediated signaling pathway (GO:0031663)2.41102586
146positive regulation of toll-like receptor signaling pathway (GO:0034123)2.40108420
147phagocytosis, recognition (GO:0006910)2.39948857
148reactive oxygen species biosynthetic process (GO:1903409)2.39599594
149regulation of platelet activation (GO:0010543)2.38782250
150negative regulation of interleukin-17 production (GO:0032700)2.38469018
151antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.35598843

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.60471945
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.65248720
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.42805555
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.91515190
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.61002365
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.57720519
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.47312339
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.26254153
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.88425778
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.86719504
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.83446661
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.59780148
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.52597771
14CLOCK_20551151_ChIP-Seq_293T_Human2.39756413
15* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38226500
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32157714
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.31599234
18TFEB_21752829_ChIP-Seq_HELA_Human2.25576538
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14876652
20NRF2_20460467_ChIP-Seq_MEFs_Mouse2.14328396
21NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.14328396
22ESR1_21235772_ChIP-Seq_MCF-7_Human2.11444281
23CJUN_26792858_Chip-Seq_BT549_Human2.08234321
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04165158
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03672021
26* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.02244394
27CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.00813848
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.97968623
29CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.95709768
30SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.90618082
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.89250697
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.87459432
33* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.85971878
34SPI1_23547873_ChIP-Seq_NB4_Human1.84059662
35* SOX2_20726797_ChIP-Seq_SW620_Human1.83293096
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81127218
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79990289
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.78851123
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.75397250
40SCL_19346495_ChIP-Seq_HPC-7_Human1.73574784
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.72386113
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.72262998
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64889091
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.59258157
45PU_27001747_Chip-Seq_BMDM_Mouse1.59253991
46* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.57360458
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.52867102
48SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45739795
49SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45739795
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.45676760
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44660096
52LXR_22158963_ChIP-Seq_LIVER_Mouse1.42449325
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41855002
54BRD4_25478319_ChIP-Seq_HGPS_Human1.41475558
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41229715
56ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.41080841
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41019371
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38710608
59* GATA1_19941826_ChIP-Seq_K562_Human1.37622263
60RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36786155
61SPI1_23127762_ChIP-Seq_K562_Human1.33940864
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33749225
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30840474
64JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30803927
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.30666402
66VDR_24787735_ChIP-Seq_THP-1_Human1.28160004
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27466658
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26845839
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22690354
70JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21828039
71RXR_22158963_ChIP-Seq_LIVER_Mouse1.21560437
72* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21297813
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20943310
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20855628
75GATA1_22025678_ChIP-Seq_K562_Human1.20375102
76* GATA2_19941826_ChIP-Seq_K562_Human1.20090917
77* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18798248
78FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17607612
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16080247
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15924954
81* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15026443
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14678793
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14052154
84GATA3_26560356_Chip-Seq_TH2_Human1.14010538
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12028125
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11717771
87ELK1_19687146_ChIP-ChIP_HELA_Human1.11196754
88EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09871839
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09714310
90* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08791632
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07824598
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07795670
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07338715
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06123598
95PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04262748
96P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01702697
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99858289
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98735080
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98125592
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98020518
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98020518
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98020518
103GATA4_25053715_ChIP-Seq_YYC3_Human0.98005465
104RUNX1_22412390_ChIP-Seq_EML_Mouse0.97591336
105MYB_26560356_Chip-Seq_TH2_Human0.95768681
106CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94785146
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94753663
108* TBX20_22080862_ChIP-Seq_HEART_Mouse0.94576483
109* TBX20_22328084_ChIP-Seq_HEART_Mouse0.94576483
110SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94348918
111ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.94055411
112STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92938063
113FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92935399
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.90264000
115GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90184241
116* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89861235
117* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88432276
118* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87406020
119VDR_24763502_ChIP-Seq_THP-1_Human0.86126599
120TP53_18474530_ChIP-ChIP_U2OS_Human0.86057125
121GATA3_27048872_Chip-Seq_THYMUS_Human0.85983893
122TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85182764
123ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85153068
124RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84686422
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84051600
126ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84041992
127RUNX_20019798_ChIP-Seq_JUKART_Human0.83994521
128* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83867436
129SMRT_27268052_Chip-Seq_Bcells_Human0.83596515
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83277655
131KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.83067516
132ESR2_21235772_ChIP-Seq_MCF-7_Human0.82164300
133CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.81030347
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.80751622
135STAT1_20625510_ChIP-Seq_HELA_Human0.78233163
136EGR1_23403033_ChIP-Seq_LIVER_Mouse0.78101572
137SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77453355
138GATA2_22383799_ChIP-Seq_G1ME_Mouse0.75611972
139* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74264411

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.13566162
2MP0005058_abnormal_lysosome_morphology4.92652353
3MP0003172_abnormal_lysosome_physiology3.02346141
4MP0002877_abnormal_melanocyte_morpholog2.62268465
5MP0001835_abnormal_antigen_presentation2.53436704
6MP0003279_aneurysm2.50989193
7MP0006054_spinal_hemorrhage2.48554705
8MP0005275_abnormal_skin_tensile2.47518602
9MP0003436_decreased_susceptibility_to2.31276068
10MP0003705_abnormal_hypodermis_morpholog2.27755255
11MP0002419_abnormal_innate_immunity2.22037310
12MP0001958_emphysema2.21224583
13MP0005503_abnormal_tendon_morphology2.17540379
14MP0000372_irregular_coat_pigmentation2.14346368
15MP0003191_abnormal_cellular_cholesterol2.12811756
16MP0006082_CNS_inflammation2.10153651
17MP0003183_abnormal_peptide_metabolism2.10007281
18MP0001533_abnormal_skeleton_physiology2.08849175
19MP0000569_abnormal_digit_pigmentation2.07972617
20MP0004272_abnormal_basement_membrane2.07916933
21MP0002148_abnormal_hypersensitivity_rea2.05738438
22MP0005257_abnormal_intraocular_pressure2.04263756
23MP0001542_abnormal_bone_strength1.93818427
24MP0000015_abnormal_ear_pigmentation1.90697919
25MP0003566_abnormal_cell_adhesion1.84910938
26MP0009840_abnormal_foam_cell1.73538656
27MP0002998_abnormal_bone_remodeling1.68646172
28MP0010386_abnormal_urinary_bladder1.67392575
29MP0002295_abnormal_pulmonary_circulatio1.64825695
30MP0003300_gastrointestinal_ulcer1.63289483
31MP0000371_diluted_coat_color1.62863305
32MP0004510_myositis1.62535949
33MP0003283_abnormal_digestive_organ1.61377394
34MP0000343_altered_response_to1.59461679
35MP0005000_abnormal_immune_tolerance1.57525623
36MP0005167_abnormal_blood-brain_barrier1.56815856
37MP0003724_increased_susceptibility_to1.52588459
38MP0003136_yellow_coat_color1.51441155
39MP0003690_abnormal_glial_cell1.50536496
40MP0005164_abnormal_response_to1.48826916
41MP0009384_cardiac_valve_regurgitation1.48430043
42MP0005390_skeleton_phenotype1.47504695
43MP0005171_absent_coat_pigmentation1.46878904
44MP0004883_abnormal_blood_vessel1.44792112
45MP0002837_dystrophic_cardiac_calcinosis1.44100824
46MP0003195_calcinosis1.42896072
47MP0009780_abnormal_chondrocyte_physiolo1.41461676
48MP0005174_abnormal_tail_pigmentation1.40878639
49MP0005075_abnormal_melanosome_morpholog1.37887266
50MP0009785_altered_susceptibility_to1.35800421
51MP0003329_amyloid_beta_deposits1.35756925
52MP0004130_abnormal_muscle_cell1.34068088
53MP0008260_abnormal_autophagy1.33087718
54MP0009764_decreased_sensitivity_to1.32836883
55MP0002452_abnormal_antigen_presenting1.31213677
56MP0001790_abnormal_immune_system1.30418538
57MP0005387_immune_system_phenotype1.30418538
58MP0002896_abnormal_bone_mineralization1.29704401
59MP0003795_abnormal_bone_structure1.29197178
60MP0005310_abnormal_salivary_gland1.27664064
61MP0003448_altered_tumor_morphology1.27135998
62MP0005464_abnormal_platelet_physiology1.26480988
63MP0003806_abnormal_nucleotide_metabolis1.25746732
64MP0000858_altered_metastatic_potential1.25730816
65MP0005451_abnormal_body_composition1.25565913
66MP0003045_fibrosis1.25496989
67MP0003303_peritoneal_inflammation1.25382165
68MP0002933_joint_inflammation1.25190046
69MP0005623_abnormal_meninges_morphology1.24875108
70MP0003075_altered_response_to1.24227460
71MP0003091_abnormal_cell_migration1.22293557
72MP0005025_abnormal_response_to1.20419239
73MP0005023_abnormal_wound_healing1.20227948
74MP0002139_abnormal_hepatobiliary_system1.19402544
75MP0004381_abnormal_hair_follicle1.19114376
76MP0003011_delayed_dark_adaptation1.14765254
77MP0003656_abnormal_erythrocyte_physiolo1.14582418
78MP0005165_increased_susceptibility_to1.13590616
79MP0004782_abnormal_surfactant_physiolog1.13584790
80MP0005670_abnormal_white_adipose1.13333130
81MP0010307_abnormal_tumor_latency1.12467763
82MP0008004_abnormal_stomach_pH1.11897412
83MP0005508_abnormal_skeleton_morphology1.11380301
84MP0002168_other_aberrant_phenotype1.11130301
85MP0001853_heart_inflammation1.09803706
86MP0005365_abnormal_bile_salt1.09187817
87MP0001545_abnormal_hematopoietic_system1.08649772
88MP0005397_hematopoietic_system_phenotyp1.08649772
89MP0001879_abnormal_lymphatic_vessel1.08341229
90MP0000604_amyloidosis1.07645154
91MP0000767_abnormal_smooth_muscle1.07244161
92MP0000013_abnormal_adipose_tissue1.06888504
93MP0004084_abnormal_cardiac_muscle1.05886415
94MP0000920_abnormal_myelination1.05812529
95MP0000685_abnormal_immune_system1.05385564
96MP0001845_abnormal_inflammatory_respons1.04241585
97MP0002060_abnormal_skin_morphology1.02680962
98MP0002090_abnormal_vision1.00782688
99MP0004947_skin_inflammation1.00343787
100MP0004036_abnormal_muscle_relaxation0.98531805
101MP0010352_gastrointestinal_tract_polyps0.98029623
102MP0002723_abnormal_immune_serum0.95710153
103MP0002971_abnormal_brown_adipose0.95333667
104MP0010155_abnormal_intestine_physiology0.94416983
105MP0002254_reproductive_system_inflammat0.94396044
106MP0002405_respiratory_system_inflammati0.94281769
107MP0004484_altered_response_of0.93722722
108MP0002693_abnormal_pancreas_physiology0.93300404
109MP0000249_abnormal_blood_vessel0.92739795
110MP0004215_abnormal_myocardial_fiber0.90247668
111MP0001851_eye_inflammation0.89263485
112MP0001819_abnormal_immune_cell0.89159259
113MP0005197_abnormal_uvea_morphology0.88610134
114MP0001324_abnormal_eye_pigmentation0.87612899
115MP0008469_abnormal_protein_level0.87578350
116MP0004019_abnormal_vitamin_homeostasis0.87172534
117MP0001243_abnormal_dermal_layer0.86745744
118MP0002420_abnormal_adaptive_immunity0.86336826
119MP0005666_abnormal_adipose_tissue0.82887073
120MP0001915_intracranial_hemorrhage0.82685986
121MP0010329_abnormal_lipoprotein_level0.81864306
122MP0002095_abnormal_skin_pigmentation0.81529189
123MP0009763_increased_sensitivity_to0.79659263
124MP0005166_decreased_susceptibility_to0.79505758
125MP0002909_abnormal_adrenal_gland0.79376759
126MP0000465_gastrointestinal_hemorrhage0.77982054
127MP0002972_abnormal_cardiac_muscle0.77639663
128MP0003646_muscle_fatigue0.77076971
129MP0000681_abnormal_thyroid_gland0.76798701
130MP0003632_abnormal_nervous_system0.76678233
131MP0001299_abnormal_eye_distance/0.76618999
132MP0005408_hypopigmentation0.76338933
133* MP0002118_abnormal_lipid_homeostasis0.76220781
134MP0002115_abnormal_skeleton_extremities0.75813016
135MP0001756_abnormal_urination0.74086316
136MP0005671_abnormal_response_to0.73600515
137MP0009643_abnormal_urine_homeostasis0.73446454
138MP0003828_pulmonary_edema0.73314677
139MP0003634_abnormal_glial_cell0.73160457
140MP0005220_abnormal_exocrine_pancreas0.71179090
141MP0003950_abnormal_plasma_membrane0.69745837
142MP0001800_abnormal_humoral_immune0.69087889
143MP0002113_abnormal_skeleton_development0.68048129
144MP0002277_abnormal_respiratory_mucosa0.66812259

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)5.74013851
2Vacuolated lymphocytes (HP:0001922)5.70266496
3Increased neuronal autofluorescent lipopigment (HP:0002074)5.55734911
4Dysostosis multiplex (HP:0000943)5.10482137
5Abnormality of liposaccharide metabolism (HP:0010968)4.79605778
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.79605778
7Abnormality of glycolipid metabolism (HP:0010969)4.79605778
8Systemic lupus erythematosus (HP:0002725)4.74600094
9Mucopolysacchariduria (HP:0008155)4.30941293
10Urinary glycosaminoglycan excretion (HP:0003541)4.30941293
11Recurrent abscess formation (HP:0002722)4.18282174
12Cervical subluxation (HP:0003308)4.12178917
13Premature rupture of membranes (HP:0001788)4.03497061
14Abnormality of polysaccharide metabolism (HP:0011012)3.91810479
15Abnormality of glycosaminoglycan metabolism (HP:0004371)3.91810479
16Abnormality of mucopolysaccharide metabolism (HP:0011020)3.91810479
17Glomerulonephritis (HP:0000099)3.69601474
18Recurrent bacterial skin infections (HP:0005406)3.58166828
19Eczematoid dermatitis (HP:0000976)3.51880561
20Vascular tortuosity (HP:0004948)3.46375617
21Vertebral compression fractures (HP:0002953)3.42988689
22Spondylolisthesis (HP:0003302)3.38482675
23Neurofibrillary tangles (HP:0002185)3.36686358
24Protrusio acetabuli (HP:0003179)3.30714701
25Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.28957732
26Arterial tortuosity (HP:0005116)3.28040022
27Purpura (HP:0000979)3.19400372
28Abnormality of macrophages (HP:0004311)3.17585524
29Cerebral aneurysm (HP:0004944)3.10134200
30Asymmetric septal hypertrophy (HP:0001670)3.07186469
31Mutism (HP:0002300)2.94477054
32Peritonitis (HP:0002586)2.88814419
33Osteolytic defects of the hand bones (HP:0009699)2.82494742
34Osteolytic defects of the phalanges of the hand (HP:0009771)2.82494742
35Aortic aneurysm (HP:0004942)2.79397283
36Aortic dissection (HP:0002647)2.74761258
37Cerebral inclusion bodies (HP:0100314)2.74217505
38Pathologic fracture (HP:0002756)2.74205189
39Disinhibition (HP:0000734)2.74046912
40Recurrent gram-negative bacterial infections (HP:0005420)2.72075609
41Axonal loss (HP:0003447)2.70180606
42Agnosia (HP:0010524)2.67304115
43Beaking of vertebral bodies (HP:0004568)2.67101375
44Spontaneous hematomas (HP:0007420)2.65562614
45Stomatitis (HP:0010280)2.61668938
46Orchitis (HP:0100796)2.60442347
47Amyloidosis (HP:0011034)2.58108334
48Soft skin (HP:0000977)2.56313133
49Albinism (HP:0001022)2.55722898
50Ocular albinism (HP:0001107)2.53520830
51Mediastinal lymphadenopathy (HP:0100721)2.52715355
52Progressive neurologic deterioration (HP:0002344)2.51268933
53Prolonged bleeding time (HP:0003010)2.50405017
54Petechiae (HP:0000967)2.48483606
55Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.47995226
56Myositis (HP:0100614)2.44980940
57Interstitial pulmonary disease (HP:0006530)2.39180886
58Increased CSF protein (HP:0002922)2.37851209
59Joint stiffness (HP:0001387)2.37623553
60Nephritis (HP:0000123)2.37617662
61Wormian bones (HP:0002645)2.32047103
62Global brain atrophy (HP:0002283)2.31902428
63Hematochezia (HP:0002573)2.31683708
64Abnormality of the periventricular white matter (HP:0002518)2.31261147
65Gingival bleeding (HP:0000225)2.30447750
66Autoimmune thrombocytopenia (HP:0001973)2.24863303
67Xanthomatosis (HP:0000991)2.24668682
68Retinal atrophy (HP:0001105)2.23668577
69Poor head control (HP:0002421)2.21582747
70Abnormality of complement system (HP:0005339)2.20171565
71Hypoplasia of the odontoid process (HP:0003311)2.18914432
72Optic neuritis (HP:0100653)2.16972084
73Retrobulbar optic neuritis (HP:0100654)2.16972084
74Elevated erythrocyte sedimentation rate (HP:0003565)2.16056843
75Thin bony cortex (HP:0002753)2.16030701
76Iris hypopigmentation (HP:0007730)2.15579070
77Chronic obstructive pulmonary disease (HP:0006510)2.14737358
78Obstructive lung disease (HP:0006536)2.14737358
79Hepatosplenomegaly (HP:0001433)2.12268034
80Myocardial infarction (HP:0001658)2.11949252
81Abnormality of dentin (HP:0010299)2.11484614
82Broad face (HP:0000283)2.11382335
83Atrophic scars (HP:0001075)2.09266769
84J-shaped sella turcica (HP:0002680)2.08260112
85Pulmonary infiltrates (HP:0002113)2.07348179
86Neuronal loss in central nervous system (HP:0002529)2.06024287
87Abnormality of the lumbar spine (HP:0100712)2.04796353
88Nausea (HP:0002018)2.04785580
89Diminished motivation (HP:0000745)2.02439883
90Apathy (HP:0000741)2.02323398
91Epistaxis (HP:0000421)2.02007371
92Ovoid vertebral bodies (HP:0003300)2.01618792
93Polyneuropathy (HP:0001271)2.01053189
94Blue sclerae (HP:0000592)2.01015356
95Short nail (HP:0001799)1.99771427
96Abnormality of the odontoid process (HP:0003310)1.99733889
97Loss of speech (HP:0002371)1.98557955
98Generalized hypopigmentation (HP:0007513)1.97558245
99Tetraparesis (HP:0002273)1.97140603
100Gingivitis (HP:0000230)1.94445269
101Keratoconjunctivitis sicca (HP:0001097)1.92719658
102Basal ganglia calcification (HP:0002135)1.91817258
103Nuclear cataract (HP:0100018)1.91589543
104Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.90746432
105Hemoptysis (HP:0002105)1.90451539
106White forelock (HP:0002211)1.88160162
107Progressive visual loss (HP:0000529)1.87638550
108Recurrent fungal infections (HP:0002841)1.87169612
109Femoral bowing (HP:0002980)1.85936582
110Conjunctival telangiectasia (HP:0000524)1.85476949
111Disproportionate short-trunk short stature (HP:0003521)1.85310254
112Blue irides (HP:0000635)1.84571010
113Aplasia/Hypoplasia of the macula (HP:0008059)1.84485776
114Ventricular fibrillation (HP:0001663)1.83299422
115Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.83244284
116Dilatation of the ascending aorta (HP:0005111)1.82872279
117Inappropriate behavior (HP:0000719)1.82192367
118Abnormality of skull ossification (HP:0002703)1.81410594
119Epidermoid cyst (HP:0200040)1.81325561
120Abnormality of the vasculature of the conjunctiva (HP:0008054)1.81114375
121Nonimmune hydrops fetalis (HP:0001790)1.80290758
122Ankle contracture (HP:0006466)1.80225270
123Peripheral demyelination (HP:0011096)1.79725031
124Complement deficiency (HP:0004431)1.79693861
125Episodic fever (HP:0001954)1.79463383
126Bone pain (HP:0002653)1.79189402
127Urticaria (HP:0001025)1.78110094
128Cardiomegaly (HP:0001640)1.77655186
129* Dementia (HP:0000726)1.77396571
130Bone cyst (HP:0012062)1.77385860
131Patchy hypopigmentation of hair (HP:0011365)1.77134613
132Abnormality of the distal phalanges of the toes (HP:0010182)1.77084020
133Shallow orbits (HP:0000586)1.77063429
134Platyspondyly (HP:0000926)1.77017648
135Mucosal telangiectasiae (HP:0100579)1.75469430
136Vertigo (HP:0002321)1.75395441
137Aplasia/Hypoplasia of the fovea (HP:0008060)1.74952530
138Hypoplasia of the fovea (HP:0007750)1.74952530
139Recurrent skin infections (HP:0001581)1.74595598
140Keratoconjunctivitis (HP:0001096)1.73492557
141Thick nail (HP:0001805)1.72859543
142Increased serum ferritin (HP:0003281)1.72575343
143Osteomyelitis (HP:0002754)1.71559350
144Aplasia/Hypoplasia affecting the retina (HP:0008061)1.71227187
145Protuberant abdomen (HP:0001538)1.71134978
146Arterial thrombosis (HP:0004420)1.70486076
147Congenital sensorineural hearing impairment (HP:0008527)1.70243663
148Syncope (HP:0001279)1.70001617
149Follicular hyperkeratosis (HP:0007502)1.69683356
150Vasculitis (HP:0002633)1.66863459
151Abnormality of iron homeostasis (HP:0011031)1.65335229
152Biconcave vertebral bodies (HP:0004586)1.64238718
153Pulmonary embolism (HP:0002204)1.63456989
154Vertebral hypoplasia (HP:0008417)1.63036465
155Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.63036465
156Upper motor neuron abnormality (HP:0002127)1.61739251
157Abnormality of the frontal sinuses (HP:0002687)1.61393722
158Symptomatic seizures (HP:0011145)1.61102509

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR23.69773417
2IRAK43.18546920
3IRAK32.80860553
4BLK2.75621114
5NEK92.73886245
6ACVR1B2.60849580
7ERN12.52979584
8ERBB32.21093076
9MAP3K32.15061327
10MAP3K142.05262703
11PASK1.99979787
12FGR1.97935153
13PBK1.88204285
14TBK11.84910733
15FRK1.84261660
16SCYL21.81014237
17KIT1.80594010
18EPHA21.75175322
19TESK11.74724281
20CAMKK21.72441375
21INSRR1.70335883
22DDR21.70248977
23TYK21.63063384
24FLT31.60212307
25TRPM71.59133396
26MST41.55265980
27TRIB31.53770901
28PDGFRA1.38912156
29FES1.38528580
30MET1.37925691
31MAP2K31.37897870
32TAOK31.35656361
33PAK41.35184117
34SYK1.35146115
35PIM21.34768043
36MARK31.32586476
37CSF1R1.27865441
38MOS1.27673003
39ZAP701.26067593
40MAPK151.25626630
41STK101.22265890
42PIK3CG1.20785434
43PDK21.20291748
44MYLK1.20265170
45IKBKB1.19279175
46JAK31.18768496
47GRK71.18681830
48RIPK11.15351016
49TTN1.14835407
50CDC42BPA1.14802161
51EIF2AK31.12549348
52LIMK11.12470129
53PTK61.12046916
54ZAK1.11867127
55CSK1.11415597
56TEC1.11209882
57EPHB11.09734101
58TAOK11.09143994
59MAPK121.05825254
60JAK11.03525320
61PRPF4B1.02640411
62RPS6KA41.01691379
63MAP3K11.01146838
64MAPKAPK31.00601408
65DAPK21.00165033
66MAP3K50.98650299
67RIPK40.98570761
68EPHA30.98190068
69PDPK10.97538014
70MAP3K130.96104217
71LRRK20.95438548
72PTK20.93993779
73BMPR20.93935375
74MAP4K10.90510115
75FGFR30.88433811
76ADRBK20.87461038
77CHUK0.87359939
78MAP3K60.86805342
79PRKAA20.86239968
80BMPR1B0.85281074
81FER0.85009697
82CAMK1D0.84658185
83GRK60.83068716
84NME20.82325335
85PRKD10.81990076
86PDK10.81608694
87MAP3K110.81136161
88MAP3K20.80968242
89TXK0.78548424
90ITK0.74947848
91LYN0.74701469
92IGF1R0.74645216
93TNK20.73799535
94MAPK70.72164947
95PAK20.70997472
96MATK0.69465658
97MAP2K60.67740095
98STK240.67512545
99BTK0.67079258
100SGK30.66725041
101PTK2B0.66210544
102SGK20.66161137
103KSR20.65637804
104PRKCD0.64629653
105HCK0.63743440
106ARAF0.62253085
107YES10.62189187
108EGFR0.61384757
109MAPKAPK20.61048787
110TGFBR10.60709369
111CAMKK10.59785080
112NTRK10.59373937
113LCK0.58829717
114IRAK10.58673010
115PDGFRB0.58618416
116STK30.57339532
117IRAK20.57245975
118PRKCE0.56064465
119PRKG20.55325934
120PRKD30.54556646
121IKBKE0.52884854
122GSK3A0.50847520
123NEK60.50689326
124FYN0.50311124
125ABL20.50151857
126INSR0.49252226
127CDK60.48881582
128CDK80.48778142
129ABL10.48063665
130TAOK20.47795742
131RET0.47410459
132PKN20.47056239
133NUAK10.46759049
134PRKCH0.46677310
135PLK20.46380481
136MAPK40.45856888
137OBSCN0.43596167
138MST1R0.43519201
139BRSK20.43120113
140EIF2AK20.43008719
141JAK20.42322323
142PINK10.41998268
143PRKACG0.41547857
144RPS6KA20.41231949
145MARK20.38163549
146DMPK0.37651276
147TIE10.37064886

Predicted pathways (KEGG)

RankGene SetZ-score
1* Lysosome_Homo sapiens_hsa041424.17150281
2Other glycan degradation_Homo sapiens_hsa005114.05203299
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.99706735
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.86415515
5Protein export_Homo sapiens_hsa030602.85077810
6Staphylococcus aureus infection_Homo sapiens_hsa051502.79670688
7Phagosome_Homo sapiens_hsa041452.58278331
8Leishmaniasis_Homo sapiens_hsa051402.12427029
9Rheumatoid arthritis_Homo sapiens_hsa053232.05974789
10Maturity onset diabetes of the young_Homo sapiens_hsa049501.99262388
11Legionellosis_Homo sapiens_hsa051341.96124329
12Pertussis_Homo sapiens_hsa051331.94482216
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.93474888
14Vibrio cholerae infection_Homo sapiens_hsa051101.91628476
15Malaria_Homo sapiens_hsa051441.88783576
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.85039792
17Allograft rejection_Homo sapiens_hsa053301.82922816
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.81317766
19Antigen processing and presentation_Homo sapiens_hsa046121.77828492
20Tuberculosis_Homo sapiens_hsa051521.72433964
21Autoimmune thyroid disease_Homo sapiens_hsa053201.63691161
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.61387723
23Osteoclast differentiation_Homo sapiens_hsa043801.55023915
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.53044830
25PPAR signaling pathway_Homo sapiens_hsa033201.46030288
26ECM-receptor interaction_Homo sapiens_hsa045121.45683338
27N-Glycan biosynthesis_Homo sapiens_hsa005101.44112849
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.41946072
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35584217
30Renin-angiotensin system_Homo sapiens_hsa046141.29672049
31Steroid biosynthesis_Homo sapiens_hsa001001.28270741
32Sulfur metabolism_Homo sapiens_hsa009201.25093853
33Collecting duct acid secretion_Homo sapiens_hsa049661.24596137
34Toxoplasmosis_Homo sapiens_hsa051451.20219903
35Amoebiasis_Homo sapiens_hsa051461.19358033
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.18118183
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13583694
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12547416
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12203682
40Salmonella infection_Homo sapiens_hsa051321.11900693
41Shigellosis_Homo sapiens_hsa051311.10503185
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.09884858
43* Sphingolipid metabolism_Homo sapiens_hsa006001.08092872
44Focal adhesion_Homo sapiens_hsa045101.07795254
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.06026515
46Prion diseases_Homo sapiens_hsa050201.04449520
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02289307
48Apoptosis_Homo sapiens_hsa042101.00124465
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96541543
50Measles_Homo sapiens_hsa051620.93726515
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89443818
52Adherens junction_Homo sapiens_hsa045200.88782538
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.88292236
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87481031
55Proteoglycans in cancer_Homo sapiens_hsa052050.87155406
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86719127
57Complement and coagulation cascades_Homo sapiens_hsa046100.83876691
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83257369
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82676319
60Galactose metabolism_Homo sapiens_hsa000520.79116777
61Mineral absorption_Homo sapiens_hsa049780.78058747
62Type I diabetes mellitus_Homo sapiens_hsa049400.77280848
63Hematopoietic cell lineage_Homo sapiens_hsa046400.77140899
64TNF signaling pathway_Homo sapiens_hsa046680.76512815
65Endocytosis_Homo sapiens_hsa041440.74607562
66Small cell lung cancer_Homo sapiens_hsa052220.71195539
67Influenza A_Homo sapiens_hsa051640.69435034
68Pancreatic cancer_Homo sapiens_hsa052120.67229606
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66906294
70Arachidonic acid metabolism_Homo sapiens_hsa005900.65756996
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65008726
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64844746
73Dorso-ventral axis formation_Homo sapiens_hsa043200.63936427
74Histidine metabolism_Homo sapiens_hsa003400.60810766
75Platelet activation_Homo sapiens_hsa046110.57708813
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55841008
77Fatty acid degradation_Homo sapiens_hsa000710.55622843
78TGF-beta signaling pathway_Homo sapiens_hsa043500.55295490
79Chemokine signaling pathway_Homo sapiens_hsa040620.54342893
80Chronic myeloid leukemia_Homo sapiens_hsa052200.54206944
81Hepatitis B_Homo sapiens_hsa051610.53642132
82Protein digestion and absorption_Homo sapiens_hsa049740.53139323
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52821401
84Fatty acid elongation_Homo sapiens_hsa000620.52482955
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52087384
86Graft-versus-host disease_Homo sapiens_hsa053320.50903111
87Hepatitis C_Homo sapiens_hsa051600.49379753
88Insulin resistance_Homo sapiens_hsa049310.47876395
89Glycerolipid metabolism_Homo sapiens_hsa005610.46721647
90Type II diabetes mellitus_Homo sapiens_hsa049300.46621684
91Tryptophan metabolism_Homo sapiens_hsa003800.45681397
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45652050
93Ovarian steroidogenesis_Homo sapiens_hsa049130.45165994
94Viral myocarditis_Homo sapiens_hsa054160.44253909
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.44219119
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.44165565
97p53 signaling pathway_Homo sapiens_hsa041150.43977861
98Renin secretion_Homo sapiens_hsa049240.43336823
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43128600
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42791850
101B cell receptor signaling pathway_Homo sapiens_hsa046620.41155713
102Prostate cancer_Homo sapiens_hsa052150.40994496
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.40719616
104Acute myeloid leukemia_Homo sapiens_hsa052210.39897243
105Melanoma_Homo sapiens_hsa052180.39400135
106ABC transporters_Homo sapiens_hsa020100.39091034
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.38891070
108GnRH signaling pathway_Homo sapiens_hsa049120.38586597
109African trypanosomiasis_Homo sapiens_hsa051430.37531201
110* Sphingolipid signaling pathway_Homo sapiens_hsa040710.37219360
111Bladder cancer_Homo sapiens_hsa052190.37149256
112Renal cell carcinoma_Homo sapiens_hsa052110.35607161
113beta-Alanine metabolism_Homo sapiens_hsa004100.35030211
114Glutathione metabolism_Homo sapiens_hsa004800.34941247
115Asthma_Homo sapiens_hsa053100.34681075
116Viral carcinogenesis_Homo sapiens_hsa052030.34612024
117Synaptic vesicle cycle_Homo sapiens_hsa047210.34293929
118Fatty acid metabolism_Homo sapiens_hsa012120.33796104
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33323566
120Starch and sucrose metabolism_Homo sapiens_hsa005000.33018625
121Regulation of autophagy_Homo sapiens_hsa041400.31704054
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.31462305
123Tyrosine metabolism_Homo sapiens_hsa003500.31422158
124Caffeine metabolism_Homo sapiens_hsa002320.30321831
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30265276
126T cell receptor signaling pathway_Homo sapiens_hsa046600.30232058
127Ether lipid metabolism_Homo sapiens_hsa005650.24998976
128Herpes simplex infection_Homo sapiens_hsa051680.24665673
129Selenocompound metabolism_Homo sapiens_hsa004500.23433193
130HIF-1 signaling pathway_Homo sapiens_hsa040660.23398027
131Pathways in cancer_Homo sapiens_hsa052000.22321350
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21364205
133Thyroid hormone synthesis_Homo sapiens_hsa049180.21256611
134Prolactin signaling pathway_Homo sapiens_hsa049170.19950664

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