ASAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of fibroblast migration (GO:0010763)3.83496950
2glucose 6-phosphate metabolic process (GO:0051156)3.52157234
3protein localization to endosome (GO:0036010)3.49803297
4detection of molecule of bacterial origin (GO:0032490)3.30252524
5plasma membrane repair (GO:0001778)3.18216251
6adenosine receptor signaling pathway (GO:0001973)3.16609966
7cellular extravasation (GO:0045123)3.10389152
8hypotonic response (GO:0006971)3.09446406
9sequestering of extracellular ligand from receptor (GO:0035581)3.08498191
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.06860532
11positive regulation by organism of defense response of other organism involved in symbiotic interact3.06860532
12modulation by symbiont of host immune response (GO:0052553)3.06860532
13positive regulation by symbiont of host defense response (GO:0052509)3.06860532
14modulation by symbiont of host defense response (GO:0052031)3.06860532
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.06860532
16positive regulation of receptor recycling (GO:0001921)3.06572122
17regulation of histone phosphorylation (GO:0033127)3.05220474
18regulation of short-term neuronal synaptic plasticity (GO:0048172)3.02675181
19negative regulation of cell killing (GO:0031342)3.00955169
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.00955169
21synaptic vesicle docking involved in exocytosis (GO:0016081)3.00551169
22embryonic camera-type eye morphogenesis (GO:0048596)2.99805320
23negative regulation of dendrite morphogenesis (GO:0050774)2.97423422
24mannose metabolic process (GO:0006013)2.95481295
25skin morphogenesis (GO:0043589)2.88026464
26synaptic vesicle maturation (GO:0016188)2.83992575
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.83916393
28astrocyte differentiation (GO:0048708)2.83378418
29glandular epithelial cell development (GO:0002068)2.81904899
30regulation of T-helper 2 cell differentiation (GO:0045628)2.79248705
31negative regulation of anoikis (GO:2000811)2.79139425
32neutrophil activation involved in immune response (GO:0002283)2.78731735
33negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.78254573
34stress fiber assembly (GO:0043149)2.76549906
35regulation of NFAT protein import into nucleus (GO:0051532)2.76490255
36regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.76438588
37glutamate secretion (GO:0014047)2.76240412
38regulation of early endosome to late endosome transport (GO:2000641)2.74746289
39wound healing, spreading of epidermal cells (GO:0035313)2.73516111
40synaptic vesicle exocytosis (GO:0016079)2.71262388
41gland morphogenesis (GO:0022612)2.68819739
42negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.68427274
43positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.68229670
44regulation of synaptic vesicle exocytosis (GO:2000300)2.65304409
45regulation of clathrin-mediated endocytosis (GO:2000369)2.63167497
46positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.60915098
47cornea development in camera-type eye (GO:0061303)2.59240694
48endodermal cell differentiation (GO:0035987)2.56198718
49positive regulation of cellular amide metabolic process (GO:0034250)2.55308500
50macrophage activation involved in immune response (GO:0002281)2.52113723
51negative regulation of norepinephrine secretion (GO:0010700)2.48776996
52proline transport (GO:0015824)2.48765172
53mesodermal cell differentiation (GO:0048333)2.47597070
54positive regulation of natural killer cell differentiation (GO:0032825)2.47520973
55platelet-derived growth factor receptor signaling pathway (GO:0048008)2.45663741
56cell adhesion mediated by integrin (GO:0033627)2.45633937
57behavioral response to pain (GO:0048266)2.45602761
58embryonic eye morphogenesis (GO:0048048)2.45548250
59regulation of anoikis (GO:2000209)2.45526183
60axon extension involved in axon guidance (GO:0048846)2.45024476
61neuron projection extension involved in neuron projection guidance (GO:1902284)2.45024476
62cell migration involved in heart development (GO:0060973)2.43417697
63negative regulation of interleukin-12 production (GO:0032695)2.42302977
64regulation of interferon-beta biosynthetic process (GO:0045357)2.41770312
65positive regulation of blood vessel endothelial cell migration (GO:0043536)2.40351991
66regulation of monocyte chemotaxis (GO:0090025)2.39536913
67negative regulation of erythrocyte differentiation (GO:0045647)2.39058846
68negative regulation of calcium ion transport into cytosol (GO:0010523)2.38469949
69response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.37964283
70response to host immune response (GO:0052572)2.37964283
71heparan sulfate proteoglycan metabolic process (GO:0030201)2.35847391
72positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.35027433
73regulation of interleukin-12 biosynthetic process (GO:0045075)2.34955765
74neutrophil mediated immunity (GO:0002446)2.34117746
75positive regulation of interferon-alpha production (GO:0032727)2.33783291
76granulocyte activation (GO:0036230)2.33180891
77mammary gland epithelial cell proliferation (GO:0033598)2.32021784
78germinal center formation (GO:0002467)2.31330718
79regulation of interferon-alpha production (GO:0032647)2.31328180
80negative regulation of leukocyte chemotaxis (GO:0002689)2.31146832
81positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.31041096
82regulation of platelet aggregation (GO:0090330)2.30945212
83positive regulation of extracellular matrix organization (GO:1903055)2.29383721
84membrane raft organization (GO:0031579)2.28579674
85regulation of synaptic vesicle transport (GO:1902803)2.28433639
86response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.28210794
87response to host (GO:0075136)2.28210794
88response to host defenses (GO:0052200)2.28210794
89regulation of membrane protein ectodomain proteolysis (GO:0051043)2.27741095
90lipopolysaccharide-mediated signaling pathway (GO:0031663)2.27467783
91negative regulation of interleukin-17 production (GO:0032700)2.27017790
92locomotory exploration behavior (GO:0035641)2.26523600
93substrate-dependent cell migration (GO:0006929)2.26466331
94cortical cytoskeleton organization (GO:0030865)2.26214636
95chondrocyte proliferation (GO:0035988)2.25689830
96mesenchymal-epithelial cell signaling (GO:0060638)2.25617072
97dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.24936972
98positive regulation of leukocyte degranulation (GO:0043302)2.24557737
99wound healing, spreading of cells (GO:0044319)2.24058199
100regulation of dendritic cell antigen processing and presentation (GO:0002604)2.23025487
101myelin assembly (GO:0032288)2.22968439
102leukocyte migration involved in inflammatory response (GO:0002523)2.22695468
103negative regulation of protein localization to plasma membrane (GO:1903077)2.20672014
104negative regulation of actin filament polymerization (GO:0030837)2.20382221
105regulation of vitamin D biosynthetic process (GO:0060556)2.19985480
106cell migration in hindbrain (GO:0021535)2.18725302
107Arp2/3 complex-mediated actin nucleation (GO:0034314)2.18076302
108macroautophagy (GO:0016236)2.18032312
109response to laminar fluid shear stress (GO:0034616)2.17910915
110NIK/NF-kappaB signaling (GO:0038061)2.17782831
111natural killer cell differentiation (GO:0001779)2.17281740
112apoptotic cell clearance (GO:0043277)2.16736601
113cortical actin cytoskeleton organization (GO:0030866)2.16478626
114neutrophil activation (GO:0042119)2.15123609
115negative regulation of glial cell proliferation (GO:0060253)2.15010302
116myeloid cell activation involved in immune response (GO:0002275)2.14844147
117positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.14788352
118respiratory burst (GO:0045730)2.14691258
119negative regulation of smooth muscle cell migration (GO:0014912)2.14545055
120SMAD protein complex assembly (GO:0007183)2.14543735
121cellular response to vitamin D (GO:0071305)2.13948290
122sodium ion export (GO:0071436)2.13942454
123regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.13661519
124positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.13661519
125regulation of protein heterodimerization activity (GO:0043497)2.13279683
126receptor catabolic process (GO:0032801)2.13095858
127macrophage activation (GO:0042116)2.11579774
128corticosteroid receptor signaling pathway (GO:0031958)2.11384835
129response to peptidoglycan (GO:0032494)2.11364757
130positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.11199545
131Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.11064654
132decidualization (GO:0046697)2.11056293
133interleukin-1-mediated signaling pathway (GO:0070498)2.11046653
134artery development (GO:0060840)2.11012458
135positive regulation of gamma-delta T cell activation (GO:0046645)2.10973619
136sequestering of actin monomers (GO:0042989)2.10824302
137natural killer cell mediated immunity (GO:0002228)2.10738875
138natural killer cell mediated cytotoxicity (GO:0042267)2.10738875
139actin filament capping (GO:0051693)2.10251443
140regulation of homotypic cell-cell adhesion (GO:0034110)2.09892133
141cellular response to virus (GO:0098586)2.09824692
142G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.09705217
143response to magnesium ion (GO:0032026)2.09649210
144regulation of ARF protein signal transduction (GO:0032012)2.09581278
145platelet aggregation (GO:0070527)2.09579197
146myeloid leukocyte mediated immunity (GO:0002444)2.09173392
147regulation of T-helper 1 cell differentiation (GO:0045625)2.09104881
148regulation of phosphoprotein phosphatase activity (GO:0043666)2.08800781
149positive regulation of neuroblast proliferation (GO:0002052)2.08141069
150regulation of neuroblast proliferation (GO:1902692)2.08078484
151positive regulation of mast cell activation (GO:0033005)2.07979367
152positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.07857129
153immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.07370032
154Fc-gamma receptor signaling pathway (GO:0038094)2.07370032
155Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.07370032
156collagen fibril organization (GO:0030199)2.07254169
157negative regulation of homotypic cell-cell adhesion (GO:0034111)2.06933719
158chondroitin sulfate biosynthetic process (GO:0030206)2.06767061
159negative regulation of adherens junction organization (GO:1903392)2.06534270
160negative regulation of focal adhesion assembly (GO:0051895)2.06534270
161negative regulation of cell junction assembly (GO:1901889)2.06534270
162positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.05811364
163integrin-mediated signaling pathway (GO:0007229)2.05323150
164regulation of mast cell degranulation (GO:0043304)2.05298672
165regulation of leukocyte degranulation (GO:0043300)2.04702634
166chondrocyte development (GO:0002063)2.04301230
167regulation of macrophage cytokine production (GO:0010935)2.04252546
168heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.03880174
169myeloid dendritic cell differentiation (GO:0043011)2.03490202
170glucocorticoid receptor signaling pathway (GO:0042921)2.03445583
171neuronal action potential propagation (GO:0019227)2.02464441
172regulation of platelet activation (GO:0010543)2.01973906
173positive regulation of cardiac muscle cell differentiation (GO:2000727)2.00812616

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.48963945
2SMAD_19615063_ChIP-ChIP_OVARY_Human3.08506652
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.03264535
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.95074468
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.94607482
6* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.78690501
7MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21340663
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.21336187
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.16035549
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14197640
11EZH2_22144423_ChIP-Seq_EOC_Human2.10849801
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.10136720
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98510165
14CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.87966897
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.84754310
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79642242
17NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.78269170
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76052945
19IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75017147
20* AHR_22903824_ChIP-Seq_MCF-7_Human1.74829250
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74810426
22* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.74601121
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.73416148
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63943109
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62708789
26* SPI1_23127762_ChIP-Seq_K562_Human1.59031675
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59000829
28* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55768289
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54842215
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.54209134
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52351452
32SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.51038572
33SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.51038572
34* ARNT_22903824_ChIP-Seq_MCF-7_Human1.50887219
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50280747
36KDM2B_26808549_Chip-Seq_DND41_Human1.50133421
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49404744
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49404744
39VDR_24787735_ChIP-Seq_THP-1_Human1.49051874
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48786225
41* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48332430
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47038684
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.46186376
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44289878
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41441591
46SALL4_18804426_ChIP-ChIP_XEN_Mouse1.38823698
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38417634
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36515455
49* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35607241
50* KDM2B_26808549_Chip-Seq_K562_Human1.35071411
51TCF7_22412390_ChIP-Seq_EML_Mouse1.34149298
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31936836
53TP63_17297297_ChIP-ChIP_HaCaT_Human1.31682665
54JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29390255
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28272689
56GBX2_23144817_ChIP-Seq_PC3_Human1.28117209
57* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27957938
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.27938797
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27286664
60TP53_16413492_ChIP-PET_HCT116_Human1.27148901
61VDR_24763502_ChIP-Seq_THP-1_Human1.26962437
62EP300_21415370_ChIP-Seq_HL-1_Mouse1.26831502
63SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26385922
64SCL_19346495_ChIP-Seq_HPC-7_Human1.26333319
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26316997
66* RUNX_20019798_ChIP-Seq_JUKART_Human1.26124170
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.26062702
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.25154835
69* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24888175
70JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23121783
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.22729909
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22217205
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22076249
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21822284
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21309207
76CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20316064
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20279445
78* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19806077
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19191024
80KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.19127170
81RNF2_27304074_Chip-Seq_ESCs_Mouse1.18648598
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18318368
83BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17795845
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17516177
85WT1_19549856_ChIP-ChIP_CCG9911_Human1.16865780
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15949213
87* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14513675
88MAF_26560356_Chip-Seq_TH1_Human1.13777698
89* TP53_18474530_ChIP-ChIP_U2OS_Human1.13586733
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13497984
91CJUN_26792858_Chip-Seq_BT549_Human1.12367906
92GATA1_19941826_ChIP-Seq_K562_Human1.12045700
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10782101
94* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10755008
95RXR_22108803_ChIP-Seq_LS180_Human1.10071622
96* TP63_23658742_ChIP-Seq_EP156T_Human1.09294978
97SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09293837
98TAF15_26573619_Chip-Seq_HEK293_Human1.08750045
99TRIM28_21343339_ChIP-Seq_HEK293_Human1.07953280
100KDM2B_26808549_Chip-Seq_JURKAT_Human1.07375157
101EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06790480
102* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05772173
103NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05050989
104CLOCK_20551151_ChIP-Seq_293T_Human1.04785784
105* UBF1/2_26484160_Chip-Seq_HMECs_Human1.04679917
106* BRD4_25478319_ChIP-Seq_HGPS_Human1.04545090
107VDR_21846776_ChIP-Seq_THP-1_Human1.04524413
108GATA1_19941827_ChIP-Seq_MEL_Mouse1.04480933
109* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03763381
110* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02757637
111SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02307594
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01956369
113* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01606944
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01435585
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01398758
116PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00545332
117EGR1_19032775_ChIP-ChIP_M12_Human1.00049117
118RARB_27405468_Chip-Seq_BRAIN_Mouse0.99283736
119* SMAD4_21799915_ChIP-Seq_A2780_Human0.99282345
120RUNX1_22412390_ChIP-Seq_EML_Mouse0.98312662
121DROSHA_22980978_ChIP-Seq_HELA_Human0.97870400
122PU_27001747_Chip-Seq_BMDM_Mouse0.97397533
123RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95984447
124PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95803081
125TCF4_18268006_ChIP-ChIP_LS174T_Human0.95346027
126NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95191944
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95191944
128PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95018718
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94956113
130GATA2_19941826_ChIP-Seq_K562_Human0.94214739
131KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94114203
132SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94002967
133* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93297181
134TBX20_22080862_ChIP-Seq_HEART_Mouse0.93093576
135TBX20_22328084_ChIP-Seq_HEART_Mouse0.93093576
136EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92902381
137* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92001621
138SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91911889
139DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91797091
140NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91760432
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87910878

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.54646519
2MP0004859_abnormal_synaptic_plasticity3.50235581
3MP0003303_peritoneal_inflammation2.87605745
4MP0004510_myositis2.71374886
5MP0002735_abnormal_chemical_nociception2.66953499
6MP0008438_abnormal_cutaneous_collagen2.59569821
7MP0006054_spinal_hemorrhage2.47138306
8MP0001968_abnormal_touch/_nociception2.41808171
9MP0002736_abnormal_nociception_after2.19113290
10MP0005623_abnormal_meninges_morphology2.06414816
11MP0001835_abnormal_antigen_presentation2.05283700
12MP0003724_increased_susceptibility_to2.03338505
13MP0001348_abnormal_lacrimal_gland1.99913569
14MP0003950_abnormal_plasma_membrane1.96029333
15MP0003091_abnormal_cell_migration1.92015952
16MP0003705_abnormal_hypodermis_morpholog1.81373125
17MP0004858_abnormal_nervous_system1.81239331
18MP0003191_abnormal_cellular_cholesterol1.80038872
19MP0003183_abnormal_peptide_metabolism1.73434166
20MP0001545_abnormal_hematopoietic_system1.71180461
21MP0005397_hematopoietic_system_phenotyp1.71180461
22MP0003172_abnormal_lysosome_physiology1.68928834
23MP0008004_abnormal_stomach_pH1.68149234
24MP0004270_analgesia1.68137349
25MP0005451_abnormal_body_composition1.66219545
26MP0001958_emphysema1.64777090
27MP0005000_abnormal_immune_tolerance1.62768759
28MP0003656_abnormal_erythrocyte_physiolo1.61494930
29MP0003566_abnormal_cell_adhesion1.59281587
30MP0005076_abnormal_cell_differentiation1.58290220
31MP0006292_abnormal_olfactory_placode1.56077034
32MP0003635_abnormal_synaptic_transmissio1.55410162
33MP0003436_decreased_susceptibility_to1.54332151
34MP0003045_fibrosis1.52308815
35MP0003300_gastrointestinal_ulcer1.52224210
36MP0002148_abnormal_hypersensitivity_rea1.51733616
37MP0002419_abnormal_innate_immunity1.51334786
38MP0005257_abnormal_intraocular_pressure1.51154369
39MP0009278_abnormal_bone_marrow1.50165672
40MP0003279_aneurysm1.49883852
41MP0003880_abnormal_central_pattern1.47653390
42MP0004808_abnormal_hematopoietic_stem1.45788512
43MP0001915_intracranial_hemorrhage1.42835711
44MP0005164_abnormal_response_to1.41671075
45MP0002733_abnormal_thermal_nociception1.40416906
46MP0000685_abnormal_immune_system1.39203467
47MP0001970_abnormal_pain_threshold1.38136021
48MP0002734_abnormal_mechanical_nocicepti1.34864267
49MP0005409_darkened_coat_color1.34267827
50MP0000428_abnormal_craniofacial_morphol1.30900255
51MP0010368_abnormal_lymphatic_system1.30178670
52MP0000343_altered_response_to1.30003233
53MP0004272_abnormal_basement_membrane1.29468311
54MP0002452_abnormal_antigen_presenting1.28748373
55MP0010352_gastrointestinal_tract_polyps1.28612786
56MP0005503_abnormal_tendon_morphology1.27187615
57MP0009046_muscle_twitch1.25918101
58MP0005671_abnormal_response_to1.21488971
59MP0001542_abnormal_bone_strength1.21227672
60MP0005464_abnormal_platelet_physiology1.20113686
61MP0004811_abnormal_neuron_physiology1.17802423
62MP0005387_immune_system_phenotype1.17683028
63MP0001790_abnormal_immune_system1.17683028
64MP0003453_abnormal_keratinocyte_physiol1.16240563
65MP0001819_abnormal_immune_cell1.15038938
66MP0002420_abnormal_adaptive_immunity1.13745179
67MP0000858_altered_metastatic_potential1.13236827
68MP0009785_altered_susceptibility_to1.11797168
69MP0002398_abnormal_bone_marrow1.11111574
70MP0001533_abnormal_skeleton_physiology1.10877768
71MP0002060_abnormal_skin_morphology1.10666990
72MP0002723_abnormal_immune_serum1.10349100
73MP0002163_abnormal_gland_morphology1.10234489
74MP0001800_abnormal_humoral_immune1.08669328
75MP0002896_abnormal_bone_mineralization1.07445423
76MP0000613_abnormal_salivary_gland1.06834475
77MP0002006_tumorigenesis1.06523638
78MP0002063_abnormal_learning/memory/cond1.05668200
79MP0008260_abnormal_autophagy1.05643649
80MP0000767_abnormal_smooth_muscle1.04163542
81MP0003448_altered_tumor_morphology1.03453765
82MP0002064_seizures1.03020165
83MP0010307_abnormal_tumor_latency1.00896427
84MP0001299_abnormal_eye_distance/1.00429902
85MP0000733_abnormal_muscle_development1.00356594
86MP0002396_abnormal_hematopoietic_system1.00013575
87MP0002998_abnormal_bone_remodeling0.97192583
88MP0001853_heart_inflammation0.97160672
89MP0005275_abnormal_skin_tensile0.96256936
90MP0005248_abnormal_Harderian_gland0.96235052
91MP0003941_abnormal_skin_development0.95858127
92MP0000015_abnormal_ear_pigmentation0.95838460
93MP0005174_abnormal_tail_pigmentation0.93427243
94MP0005025_abnormal_response_to0.93144088
95MP0006082_CNS_inflammation0.90446534
96MP0001849_ear_inflammation0.87942044
97MP0002295_abnormal_pulmonary_circulatio0.87848130
98MP0004947_skin_inflammation0.87324712
99MP0002332_abnormal_exercise_endurance0.86865076
100MP0002166_altered_tumor_susceptibility0.86620572
101MP0003795_abnormal_bone_structure0.86217652
102MP0003385_abnormal_body_wall0.86005569
103MP0010386_abnormal_urinary_bladder0.84656286
104MP0005595_abnormal_vascular_smooth0.84533275
105MP0002405_respiratory_system_inflammati0.82450025
106MP0002184_abnormal_innervation0.82434315
107MP0000716_abnormal_immune_system0.82176131
108MP0006138_congestive_heart_failure0.80997424
109MP0000534_abnormal_ureter_morphology0.80577857
110MP0001614_abnormal_blood_vessel0.79615958
111MP0009745_abnormal_behavioral_response0.79460831
112MP0002877_abnormal_melanocyte_morpholog0.79281772
113MP0005390_skeleton_phenotype0.79039405
114MP0002925_abnormal_cardiovascular_devel0.77511671
115MP0000371_diluted_coat_color0.77170370
116MP0000249_abnormal_blood_vessel0.77035270
117MP0000003_abnormal_adipose_tissue0.76700569
118MP0001243_abnormal_dermal_layer0.75466473
119MP0004233_abnormal_muscle_weight0.74984869
120MP0003075_altered_response_to0.74529802
121MP0005197_abnormal_uvea_morphology0.74472810
122MP0001175_abnormal_lung_morphology0.73971344
123MP0001851_eye_inflammation0.73127372
124MP0005310_abnormal_salivary_gland0.72839458
125MP0003942_abnormal_urinary_system0.71858725
126MP0009780_abnormal_chondrocyte_physiolo0.71142600
127MP0002168_other_aberrant_phenotype0.71043020
128MP0000689_abnormal_spleen_morphology0.70778810
129MP0002113_abnormal_skeleton_development0.70745725
130MP0005621_abnormal_cell_physiology0.70257714
131MP0002429_abnormal_blood_cell0.69539971
132MP0004134_abnormal_chest_morphology0.69151216
133MP0002067_abnormal_sensory_capabilities0.68769053
134MP0009384_cardiac_valve_regurgitation0.68131925
135MP0005023_abnormal_wound_healing0.67768959
136MP0005058_abnormal_lysosome_morphology0.67506237
137MP0003690_abnormal_glial_cell0.66768512
138MP0002572_abnormal_emotion/affect_behav0.66643887
139MP0003828_pulmonary_edema0.66282294
140MP0002177_abnormal_outer_ear0.65908992
141MP0001879_abnormal_lymphatic_vessel0.65229098
142MP0009764_decreased_sensitivity_to0.64700256
143MP0008569_lethality_at_weaning0.64251281
144MP0004883_abnormal_blood_vessel0.63745408
145MP0002722_abnormal_immune_system0.63477235
146MP0000604_amyloidosis0.61935655

Predicted human phenotypes

RankGene SetZ-score
1Abnormal gallbladder physiology (HP:0012438)3.84729971
2Cholecystitis (HP:0001082)3.84729971
3Peripheral hypomyelination (HP:0007182)3.79095167
4Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.67284481
5Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.33081776
6Spondylolisthesis (HP:0003302)3.26384197
7Arterial tortuosity (HP:0005116)3.25699763
8Protrusio acetabuli (HP:0003179)3.25278312
9Vascular tortuosity (HP:0004948)3.24156603
10Submucous cleft hard palate (HP:0000176)3.12062838
11Morphological abnormality of the middle ear (HP:0008609)3.06717075
12Recurrent abscess formation (HP:0002722)2.84369060
13Difficulty running (HP:0009046)2.81290618
14Thoracolumbar scoliosis (HP:0002944)2.80095069
15Osteolytic defects of the hand bones (HP:0009699)2.69519417
16Osteolytic defects of the phalanges of the hand (HP:0009771)2.69519417
17Abnormality of glycosphingolipid metabolism (HP:0004343)2.65786025
18Abnormality of glycolipid metabolism (HP:0010969)2.65786025
19Abnormality of liposaccharide metabolism (HP:0010968)2.65786025
20Eczematoid dermatitis (HP:0000976)2.65585709
21Aplasia/Hypoplasia of the fovea (HP:0008060)2.62554912
22Hypoplasia of the fovea (HP:0007750)2.62554912
23Midline defect of the nose (HP:0004122)2.57265130
24Increased mean platelet volume (HP:0011877)2.57087944
25Recurrent bacterial skin infections (HP:0005406)2.53739010
26Dysostosis multiplex (HP:0000943)2.51376412
27Abnormal platelet volume (HP:0011876)2.51233324
28Cerebral aneurysm (HP:0004944)2.50268636
29J-shaped sella turcica (HP:0002680)2.49524203
30Follicular hyperkeratosis (HP:0007502)2.49011515
31Dilatation of the ascending aorta (HP:0005111)2.45911869
32Congenital glaucoma (HP:0001087)2.45349025
33Reticulocytosis (HP:0001923)2.44758344
34Peritonitis (HP:0002586)2.44340223
35Myocardial infarction (HP:0001658)2.41491489
36Overgrowth (HP:0001548)2.40627061
37Abnormality of macrophages (HP:0004311)2.36874517
38Absent eyebrow (HP:0002223)2.36426179
39Premature rupture of membranes (HP:0001788)2.33867550
40Broad face (HP:0000283)2.27691555
41Wormian bones (HP:0002645)2.27341749
42Absent frontal sinuses (HP:0002688)2.27212079
43Aplasia/Hypoplasia of the macula (HP:0008059)2.26716470
44Vertebral compression fractures (HP:0002953)2.24520406
45Syringomyelia (HP:0003396)2.21216477
46Spinal cord lesions (HP:0100561)2.21216477
47Spontaneous hematomas (HP:0007420)2.17965915
48Vacuolated lymphocytes (HP:0001922)2.16827643
49Focal seizures (HP:0007359)2.16326748
50Absent eyelashes (HP:0000561)2.12262860
51Cutaneous finger syndactyly (HP:0010554)2.11998505
52Mucopolysacchariduria (HP:0008155)2.11604084
53Urinary glycosaminoglycan excretion (HP:0003541)2.11604084
54Genu recurvatum (HP:0002816)2.09892262
55Camptodactyly of toe (HP:0001836)2.08987998
56Deformed sella turcica (HP:0002681)2.08406780
57Chin dimple (HP:0010751)2.08305638
58Menorrhagia (HP:0000132)2.07826778
59Aneurysm (HP:0002617)2.06825025
60Shallow orbits (HP:0000586)2.06646457
61Fragile skin (HP:0001030)2.06346783
62Febrile seizures (HP:0002373)2.06198216
63Bilateral microphthalmos (HP:0007633)2.05015309
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04522634
65Abnormality of polysaccharide metabolism (HP:0011012)2.04522634
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04522634
67Aplasia/Hypoplasia affecting the retina (HP:0008061)2.03063963
68Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.01144837
69Overlapping toe (HP:0001845)2.00315037
70Spinal rigidity (HP:0003306)2.00282415
71Atrophic scars (HP:0001075)1.98995765
72Action tremor (HP:0002345)1.98365318
73Papilledema (HP:0001085)1.97544394
74Joint laxity (HP:0001388)1.95778832
75Achilles tendon contracture (HP:0001771)1.95737442
76Soft skin (HP:0000977)1.95114295
77Myokymia (HP:0002411)1.95056455
78Prolonged bleeding time (HP:0003010)1.92470562
79Polycythemia (HP:0001901)1.91888156
80Abnormality of the fovea (HP:0000493)1.89742710
81Subacute progressive viral hepatitis (HP:0006572)1.89176578
82Tibial bowing (HP:0002982)1.88857094
83Asymmetric septal hypertrophy (HP:0001670)1.88555323
84Hip contracture (HP:0003273)1.88369776
85Myositis (HP:0100614)1.88088418
86Distal arthrogryposis (HP:0005684)1.87591729
87Mediastinal lymphadenopathy (HP:0100721)1.87460788
88Gingival bleeding (HP:0000225)1.87357533
89Papillary thyroid carcinoma (HP:0002895)1.87338625
90Narrow palate (HP:0000189)1.87116442
91Hematochezia (HP:0002573)1.86737491
92Atonic seizures (HP:0010819)1.86541940
93Thin bony cortex (HP:0002753)1.85886812
94Increased density of long bones (HP:0006392)1.85121429
95Increased connective tissue (HP:0009025)1.85033781
96Epileptic encephalopathy (HP:0200134)1.84210589
97Obstructive sleep apnea (HP:0002870)1.84181523
98Mask-like facies (HP:0000298)1.84086815
99Disproportionate tall stature (HP:0001519)1.83681505
100Flared iliac wings (HP:0002869)1.83474786
101Blue sclerae (HP:0000592)1.82579755
102Striae distensae (HP:0001065)1.82111550
103Orchitis (HP:0100796)1.81835802
104Disinhibition (HP:0000734)1.81573217
105Bowel diverticulosis (HP:0005222)1.81572594
106Optic neuritis (HP:0100653)1.81397515
107Retrobulbar optic neuritis (HP:0100654)1.81397515
108Ankle contracture (HP:0006466)1.80588130
109Mitral valve prolapse (HP:0001634)1.80541112
110Hypercortisolism (HP:0001578)1.79133023
111Abnormality of the Achilles tendon (HP:0005109)1.79090515
112Distal lower limb amyotrophy (HP:0008944)1.78507655
113Progressive cerebellar ataxia (HP:0002073)1.78175862
114Absent phalangeal crease (HP:0006109)1.77725273
115Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.77366801
116Obstructive lung disease (HP:0006536)1.77194574
117Chronic obstructive pulmonary disease (HP:0006510)1.77194574
118Inappropriate behavior (HP:0000719)1.76770812
119Lower limb amyotrophy (HP:0007210)1.76643310
120Knee flexion contracture (HP:0006380)1.76455842
121Slender build (HP:0001533)1.76348439
122Short nail (HP:0001799)1.76073266
123Decreased motor nerve conduction velocity (HP:0003431)1.76040363
124Wrist flexion contracture (HP:0001239)1.76026030
125Aortic aneurysm (HP:0004942)1.75911180
126Cellulitis (HP:0100658)1.75259787
127Mitral regurgitation (HP:0001653)1.74586917
128Mitral stenosis (HP:0001718)1.74437234
129Aortic dissection (HP:0002647)1.74134751
130Flexion contracture of toe (HP:0005830)1.73803220
131Joint contractures involving the joints of the feet (HP:0100492)1.73803220
132Asymmetry of the thorax (HP:0001555)1.73554110
133Abnormality of the frontal sinuses (HP:0002687)1.72426247
134Nuclear cataract (HP:0100018)1.71979266
135Epistaxis (HP:0000421)1.71862449
136Apathy (HP:0000741)1.71781577
137Cholelithiasis (HP:0001081)1.71671746
138Global brain atrophy (HP:0002283)1.71177178
139Relative macrocephaly (HP:0004482)1.70320410
140Vertebral arch anomaly (HP:0008438)1.69277821
141Focal motor seizures (HP:0011153)1.69032112
142Bruising susceptibility (HP:0000978)1.68413711
143Ulnar claw (HP:0001178)1.68331028
144Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.68069381
145Cerebral inclusion bodies (HP:0100314)1.67642310
146Cervical subluxation (HP:0003308)1.67405093
147Broad palm (HP:0001169)1.66462327
148Diminished motivation (HP:0000745)1.66257505
149Protuberant abdomen (HP:0001538)1.65483905
150Increased variability in muscle fiber diameter (HP:0003557)1.65478466
151Spinal canal stenosis (HP:0003416)1.64464689
152Neonatal short-limb short stature (HP:0008921)1.64158102
153Gingivitis (HP:0000230)1.64094572
154Esophageal varix (HP:0002040)1.63492285
155Abnormality of the pubic bones (HP:0003172)1.63048139
156Hypoventilation (HP:0002791)1.62943289
157Increased cerebral lipofuscin (HP:0011813)1.62801229
158Down-sloping shoulders (HP:0200021)1.62619947
159Upper limb amyotrophy (HP:0009129)1.61965013
160Distal upper limb amyotrophy (HP:0007149)1.61965013
161Failure to thrive in infancy (HP:0001531)1.60930358
162Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.60628988
163Autoimmune thrombocytopenia (HP:0001973)1.59906844
164Arterial thrombosis (HP:0004420)1.58490511
165Bladder diverticulum (HP:0000015)1.57636645
166Dysmetric saccades (HP:0000641)1.57521104
167Abnormality of the vasculature of the conjunctiva (HP:0008054)1.57274890
168Recurrent fungal infections (HP:0002841)1.56990778
169Dislocated radial head (HP:0003083)1.56269099
170Cutaneous syndactyly (HP:0012725)1.56095311
171Macroorchidism (HP:0000053)1.56064680
172Acanthocytosis (HP:0001927)1.55711599
173Abnormal hair whorl (HP:0010721)1.54309920
174Long toe (HP:0010511)1.53434056
175Aplasia/Hypoplasia of the sternum (HP:0006714)1.52682297
176Skull defect (HP:0001362)1.51263827

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.33012042
2BLK3.20456432
3KSR23.12435718
4IRAK32.75224180
5TESK12.31674518
6MAP2K32.26685200
7TAOK32.24676485
8SIK22.19812927
9DAPK22.15225118
10TGFBR22.02841738
11TRIB31.98719336
12RET1.87828001
13MAP3K91.82323067
14HIPK21.81477433
15PLK21.74161005
16TESK21.71907392
17EPHB11.70631350
18GRK51.69577228
19PAK61.69354109
20FGR1.68107352
21MAP3K21.64421751
22LATS11.62836483
23MAP4K11.58398027
24LIMK11.58236660
25CSK1.57228441
26MAP3K31.53063039
27MET1.51531096
28MYLK1.51178336
29SCYL21.50870193
30MINK11.49770191
31PIM21.41054002
32NTRK31.39867050
33MAP3K141.38736737
34MAP3K61.37378003
35ICK1.35517806
36PRKD21.35000394
37IRAK21.32481088
38FES1.31276521
39CDK81.30839451
40AKT31.29757764
41PKN21.28688034
42STK381.27827059
43CAMKK11.27204919
44YES11.26063157
45DAPK11.25227607
46LATS21.21171259
47MAP3K41.19582209
48MAP3K131.15358309
49TTN1.15200527
50TAOK11.15174024
51JAK11.13073971
52NTRK11.11589415
53MARK21.11050251
54JAK31.09418561
55PRPF4B1.09216140
56KSR11.08658637
57SGK21.05882868
58SGK31.05762816
59MAP3K121.05568632
60PNCK1.05517297
61TBK11.04593315
62TLK11.03452249
63GRK71.02607848
64MAP2K71.02071348
65ERN11.01233189
66BMX0.98915921
67WNK10.98712306
68PRKD30.97273626
69RIPK10.96289312
70PDGFRA0.96235389
71DDR20.96000544
72PAK40.95544362
73MAP3K10.94767173
74DMPK0.91537067
75MAPK70.91525387
76PIK3CG0.91038443
77TAOK20.90624866
78FLT30.89468397
79CAMKK20.88250989
80MOS0.87732012
81HCK0.87335423
82EEF2K0.86795283
83TRPM70.86650558
84BMPR1B0.86421406
85MAP2K10.86178390
86SIK10.86001908
87ERBB40.85317876
88ZAP700.83307782
89CDK120.81448732
90IRAK40.79836338
91FGFR30.79349197
92MTOR0.78695215
93TYRO30.78643101
94SYK0.78463006
95JAK20.76640901
96CSF1R0.76547504
97RPS6KA20.76262074
98KIT0.75708669
99TYK20.75692922
100IKBKB0.73292325
101SIK30.72553743
102MAP2K40.72177033
103NEK90.71655776
104PDPK10.70402274
105LRRK20.69370426
106FRK0.68758944
107CCNB10.66859836
108CAMK1G0.66303145
109STK240.65040550
110ROCK10.64503684
111EPHA30.63757389
112MELK0.63285731
113CDK50.62542804
114BMPR20.62482785
115IRAK10.62359067
116GSK3A0.61697172
117DAPK30.58825861
118TGFBR10.58217255
119STK100.56075841
120CDK60.55955690
121CDK140.55585393
122PDK10.55377323
123CDC42BPA0.53427081
124EPHB20.51977704
125STK30.51552211
126RPS6KA40.51088732
127CDK180.50407978
128PRKCH0.50319919
129MATK0.50312375
130CAMK1D0.49808738
131CHUK0.49601115
132ALK0.49124189
133CDK150.48822006
134BRD40.47316948
135ROCK20.47243659
136PTK20.46803435
137CASK0.45538823
138RAF10.45184644
139PDGFRB0.44266141
140CDK90.42967834
141MAP3K50.42317557
142* PTK2B0.41500846
143RPS6KL10.41497634
144RPS6KC10.41497634
145ABL20.41341148
146PTK60.41269129
147PAK20.41264580
148MARK30.40742595
149SGK4940.40355066
150SGK2230.40355066
151STK38L0.38742920

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.84635298
2Other glycan degradation_Homo sapiens_hsa005111.99702415
3Glycosaminoglycan degradation_Homo sapiens_hsa005311.62551072
4Leishmaniasis_Homo sapiens_hsa051401.59459056
5Synaptic vesicle cycle_Homo sapiens_hsa047211.55531144
6* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42601147
7Osteoclast differentiation_Homo sapiens_hsa043801.42210046
8ECM-receptor interaction_Homo sapiens_hsa045121.40719438
9Glioma_Homo sapiens_hsa052141.40614045
10Chronic myeloid leukemia_Homo sapiens_hsa052201.34414245
11Type II diabetes mellitus_Homo sapiens_hsa049301.30430325
12Salmonella infection_Homo sapiens_hsa051321.30375200
13Neurotrophin signaling pathway_Homo sapiens_hsa047221.27083355
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26678670
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25614703
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25267697
17Tuberculosis_Homo sapiens_hsa051521.25070367
18Shigellosis_Homo sapiens_hsa051311.24934841
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23823646
20Carbohydrate digestion and absorption_Homo sapiens_hsa049731.23416880
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23289795
22Dorso-ventral axis formation_Homo sapiens_hsa043201.22633983
23TNF signaling pathway_Homo sapiens_hsa046681.22028576
24Lysosome_Homo sapiens_hsa041421.20052777
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18546728
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17193688
27Long-term potentiation_Homo sapiens_hsa047201.16386453
28B cell receptor signaling pathway_Homo sapiens_hsa046621.15843873
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15306776
30Toxoplasmosis_Homo sapiens_hsa051451.15133788
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11229645
32Small cell lung cancer_Homo sapiens_hsa052221.09322950
33MicroRNAs in cancer_Homo sapiens_hsa052061.08167754
34Pancreatic cancer_Homo sapiens_hsa052121.07789302
35Platelet activation_Homo sapiens_hsa046111.07230586
36Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.06571067
37Pertussis_Homo sapiens_hsa051331.05184658
38Phagosome_Homo sapiens_hsa041451.04178553
39Chemokine signaling pathway_Homo sapiens_hsa040621.03392717
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03327115
41VEGF signaling pathway_Homo sapiens_hsa043701.02389265
42Prostate cancer_Homo sapiens_hsa052151.01212693
43Malaria_Homo sapiens_hsa051440.99465455
44Hepatitis B_Homo sapiens_hsa051610.98204914
45Non-small cell lung cancer_Homo sapiens_hsa052230.94288569
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93315550
47Acute myeloid leukemia_Homo sapiens_hsa052210.93123833
48Hepatitis C_Homo sapiens_hsa051600.92448646
49Hematopoietic cell lineage_Homo sapiens_hsa046400.92289557
50ErbB signaling pathway_Homo sapiens_hsa040120.91941943
51HIF-1 signaling pathway_Homo sapiens_hsa040660.90993234
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.89415362
53Viral myocarditis_Homo sapiens_hsa054160.89372321
54Olfactory transduction_Homo sapiens_hsa047400.89251388
55Salivary secretion_Homo sapiens_hsa049700.88522138
56Colorectal cancer_Homo sapiens_hsa052100.88136243
57FoxO signaling pathway_Homo sapiens_hsa040680.87294328
58GnRH signaling pathway_Homo sapiens_hsa049120.87213483
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87035761
60Rheumatoid arthritis_Homo sapiens_hsa053230.86706744
61Influenza A_Homo sapiens_hsa051640.86434132
62Apoptosis_Homo sapiens_hsa042100.86161951
63Amoebiasis_Homo sapiens_hsa051460.85665763
64mTOR signaling pathway_Homo sapiens_hsa041500.85639283
65Melanoma_Homo sapiens_hsa052180.85492231
66Notch signaling pathway_Homo sapiens_hsa043300.85414301
67Oxytocin signaling pathway_Homo sapiens_hsa049210.84833388
68Measles_Homo sapiens_hsa051620.84470080
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83946260
70Prolactin signaling pathway_Homo sapiens_hsa049170.83812337
71Endometrial cancer_Homo sapiens_hsa052130.81795956
72Proteoglycans in cancer_Homo sapiens_hsa052050.81632985
73MAPK signaling pathway_Homo sapiens_hsa040100.81609376
74Staphylococcus aureus infection_Homo sapiens_hsa051500.81567919
75Circadian entrainment_Homo sapiens_hsa047130.81533923
76* Endocytosis_Homo sapiens_hsa041440.81091232
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.80871670
78Cholinergic synapse_Homo sapiens_hsa047250.80429994
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79873923
80Estrogen signaling pathway_Homo sapiens_hsa049150.79795156
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79228203
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78403291
83Long-term depression_Homo sapiens_hsa047300.77838642
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77491654
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76161328
86T cell receptor signaling pathway_Homo sapiens_hsa046600.76040348
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.75249570
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74952039
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74847916
90Focal adhesion_Homo sapiens_hsa045100.74781742
91Allograft rejection_Homo sapiens_hsa053300.74661024
92Renal cell carcinoma_Homo sapiens_hsa052110.74608352
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74407586
94Pathways in cancer_Homo sapiens_hsa052000.73186908
95Rap1 signaling pathway_Homo sapiens_hsa040150.72286889
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70768240
97Bladder cancer_Homo sapiens_hsa052190.70715069
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70407792
99Morphine addiction_Homo sapiens_hsa050320.70257412
100Collecting duct acid secretion_Homo sapiens_hsa049660.70145683
101Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69773796
102Glutamatergic synapse_Homo sapiens_hsa047240.69117405
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69012126
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67362661
105Gap junction_Homo sapiens_hsa045400.67112802
106Thyroid cancer_Homo sapiens_hsa052160.67067988
107Dilated cardiomyopathy_Homo sapiens_hsa054140.67038648
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.66239637
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66193176
110African trypanosomiasis_Homo sapiens_hsa051430.65829334
111Legionellosis_Homo sapiens_hsa051340.65687097
112TGF-beta signaling pathway_Homo sapiens_hsa043500.65287249
113Renin secretion_Homo sapiens_hsa049240.65082841
114Type I diabetes mellitus_Homo sapiens_hsa049400.65061834
115Inositol phosphate metabolism_Homo sapiens_hsa005620.64731650
116Dopaminergic synapse_Homo sapiens_hsa047280.64507626
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.64185965
118Adherens junction_Homo sapiens_hsa045200.64027858
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.63969533
120Nicotine addiction_Homo sapiens_hsa050330.63583059
121Choline metabolism in cancer_Homo sapiens_hsa052310.62820085
122Insulin resistance_Homo sapiens_hsa049310.60815745
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.60795297
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59985316
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58552948
126Prion diseases_Homo sapiens_hsa050200.56523920
127Herpes simplex infection_Homo sapiens_hsa051680.56210037

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