ASAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.05401383
2desmosome organization (GO:0002934)4.32011501
3vocalization behavior (GO:0071625)4.17986722
4cell communication by electrical coupling (GO:0010644)4.08312640
5cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.99858972
6regulation of short-term neuronal synaptic plasticity (GO:0048172)3.96150651
7sodium ion export (GO:0071436)3.91653895
8layer formation in cerebral cortex (GO:0021819)3.89875786
9cell adhesion mediated by integrin (GO:0033627)3.81809448
10locomotory exploration behavior (GO:0035641)3.76939512
11synaptic vesicle docking involved in exocytosis (GO:0016081)3.75341211
12axonal fasciculation (GO:0007413)3.72085938
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.69937896
14establishment of nucleus localization (GO:0040023)3.58034010
15dendritic spine morphogenesis (GO:0060997)3.57531430
16cellular potassium ion homeostasis (GO:0030007)3.55762743
17retina vasculature morphogenesis in camera-type eye (GO:0061299)3.51197369
18synaptic vesicle maturation (GO:0016188)3.49517989
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.49507731
20positive regulation of synapse maturation (GO:0090129)3.44709094
21synaptic vesicle exocytosis (GO:0016079)3.39408147
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.38833549
23glutamate secretion (GO:0014047)3.36016929
24cell migration in hindbrain (GO:0021535)3.35204699
25synaptic vesicle endocytosis (GO:0048488)3.31617558
26mesodermal cell differentiation (GO:0048333)3.26734140
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.23628338
28neuron recognition (GO:0008038)3.22936300
29innervation (GO:0060384)3.22594046
30chondrocyte proliferation (GO:0035988)3.22064311
31paraxial mesoderm development (GO:0048339)3.21982542
32response to pheromone (GO:0019236)3.19613031
33cell-substrate junction assembly (GO:0007044)3.19271218
34regulation of glutamate receptor signaling pathway (GO:1900449)3.18020846
35cell communication involved in cardiac conduction (GO:0086065)3.15747252
36substrate-dependent cell migration (GO:0006929)3.15259776
37dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.09170582
38negative regulation of chondrocyte differentiation (GO:0032331)3.07934355
39glutamate receptor signaling pathway (GO:0007215)3.01061700
40dendrite morphogenesis (GO:0048813)2.99647834
41skin morphogenesis (GO:0043589)2.96456283
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.96066085
43central nervous system projection neuron axonogenesis (GO:0021952)2.95753570
44protein localization to synapse (GO:0035418)2.94517859
45activation of protein kinase A activity (GO:0034199)2.94251349
46negative regulation of protein localization to cell surface (GO:2000009)2.89593937
47lymphangiogenesis (GO:0001946)2.89158954
48cerebellar Purkinje cell differentiation (GO:0021702)2.87099291
49neuron cell-cell adhesion (GO:0007158)2.86691587
50negative regulation of axon extension involved in axon guidance (GO:0048843)2.85777589
51proline transport (GO:0015824)2.85706242
52ganglion development (GO:0061548)2.85367083
53establishment of tissue polarity (GO:0007164)2.85195823
54establishment of planar polarity (GO:0001736)2.85195823
55regulation of synaptic vesicle exocytosis (GO:2000300)2.85182563
56negative regulation of keratinocyte proliferation (GO:0010839)2.84580705
57synaptic transmission, glutamatergic (GO:0035249)2.84302831
58neurotransmitter secretion (GO:0007269)2.83910049
59regulation of synapse structural plasticity (GO:0051823)2.83847467
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.83319014
61regulation of neuronal synaptic plasticity (GO:0048168)2.83120236
62regulation of transforming growth factor beta2 production (GO:0032909)2.81457351
63cell migration involved in sprouting angiogenesis (GO:0002042)2.78401480
64regulation of long-term neuronal synaptic plasticity (GO:0048169)2.78020022
65epithelial cell-cell adhesion (GO:0090136)2.78018637
66negative regulation of axon guidance (GO:1902668)2.77365823
67cytoskeletal anchoring at plasma membrane (GO:0007016)2.72209060
68dendritic spine organization (GO:0097061)2.71264815
69exploration behavior (GO:0035640)2.71178987
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.70782402
71positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70669914
72endodermal cell differentiation (GO:0035987)2.69833213
73bundle of His cell to Purkinje myocyte communication (GO:0086069)2.69817132
74cellular sodium ion homeostasis (GO:0006883)2.69259379
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.68890938
76membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.68833184
77regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.68430962
78regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.67960414
79regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.67211517
80membrane repolarization (GO:0086009)2.66098191
81cerebellar granule cell differentiation (GO:0021707)2.65814956
82substrate adhesion-dependent cell spreading (GO:0034446)2.65429914
83SMAD protein complex assembly (GO:0007183)2.64354480
84regulation of synapse maturation (GO:0090128)2.63500702
85nucleus localization (GO:0051647)2.62600442
86neuron projection extension involved in neuron projection guidance (GO:1902284)2.61656218
87axon extension involved in axon guidance (GO:0048846)2.61656218
88neuron projection extension (GO:1990138)2.61611062
89glial cell proliferation (GO:0014009)2.59804640
90auditory behavior (GO:0031223)2.59449520
91potassium ion homeostasis (GO:0055075)2.58513103
92apical protein localization (GO:0045176)2.56920541
93planar cell polarity pathway involved in neural tube closure (GO:0090179)2.56874341
94Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.56816402
95long-term memory (GO:0007616)2.55735608
96regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.55631354
97gamma-aminobutyric acid transport (GO:0015812)2.54338643
98negative regulation of cytosolic calcium ion concentration (GO:0051481)2.52271423
99regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.51198310
100negative chemotaxis (GO:0050919)2.50566325
101negative regulation of stem cell proliferation (GO:2000647)2.50524532
102negative regulation of sodium ion transport (GO:0010766)2.49888237
103regulation of synaptic vesicle transport (GO:1902803)2.49729127
104regulation of establishment of planar polarity (GO:0090175)2.48863060
105neuron-neuron synaptic transmission (GO:0007270)2.48194361
106neuromuscular process controlling balance (GO:0050885)2.46331358
107positive regulation of potassium ion transmembrane transport (GO:1901381)2.46315489
108neurotransmitter-gated ion channel clustering (GO:0072578)2.46172456
109semaphorin-plexin signaling pathway (GO:0071526)2.46051847
110regulation of dendritic spine morphogenesis (GO:0061001)2.45134035
111embryonic foregut morphogenesis (GO:0048617)2.44225278
112regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43803998
113axon extension (GO:0048675)2.43787494
114atrial cardiac muscle cell action potential (GO:0086014)2.43504715
115negative regulation of catenin import into nucleus (GO:0035414)2.43089743
116behavioral fear response (GO:0001662)2.41754576
117behavioral defense response (GO:0002209)2.41754576
118notochord development (GO:0030903)2.41319042
119chemosensory behavior (GO:0007635)2.40590387
120gap junction assembly (GO:0016264)2.40077748
121membrane repolarization during action potential (GO:0086011)2.39860908
122collagen fibril organization (GO:0030199)2.39808637
123regulation of glomerular filtration (GO:0003093)2.39339243
124regulation of axon guidance (GO:1902667)2.38622857
125hypotonic response (GO:0006971)2.38505824
126asymmetric protein localization (GO:0008105)2.38169626
127hippo signaling (GO:0035329)2.37880179
128growth hormone secretion (GO:0030252)2.37783804
129regulation of axon extension involved in axon guidance (GO:0048841)2.37726753
130cardiac conduction (GO:0061337)2.37620728
131protein localization to microtubule (GO:0035372)2.37324540
132endothelial cell morphogenesis (GO:0001886)2.36194521
133ventricular cardiac muscle cell action potential (GO:0086005)2.36086029
134regulation of heart rate by cardiac conduction (GO:0086091)2.36067153
135lens morphogenesis in camera-type eye (GO:0002089)2.36064236
136wound healing, spreading of epidermal cells (GO:0035313)2.35208492
137regulation of membrane repolarization (GO:0060306)2.34124115
138potassium ion import (GO:0010107)2.33685803
139synapse organization (GO:0050808)2.33416903
140cell junction assembly (GO:0034329)2.33127994
141membrane assembly (GO:0071709)2.31980531
142regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.31957116
143regulation of excitatory postsynaptic membrane potential (GO:0060079)2.31618496
144regulation of postsynaptic membrane potential (GO:0060078)2.31515439
145limb bud formation (GO:0060174)2.31285736
146negative regulation of cartilage development (GO:0061037)2.30912680
147plasma membrane repair (GO:0001778)2.30800959
148morphogenesis of an epithelial sheet (GO:0002011)2.28992911
149regulation of synaptic plasticity (GO:0048167)2.28522310
150regulation of clathrin-mediated endocytosis (GO:2000369)2.28284653
151response to auditory stimulus (GO:0010996)2.28225997
152postsynaptic membrane organization (GO:0001941)2.27888620
153artery development (GO:0060840)2.27373624
154cardiac muscle cell action potential (GO:0086001)2.27232026
155positive regulation of blood vessel endothelial cell migration (GO:0043536)2.27169250
156regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.26801734
157vascular endothelial growth factor signaling pathway (GO:0038084)2.25944862
158adherens junction assembly (GO:0034333)2.24157786
159myoblast fusion (GO:0007520)2.24157715
160glomerular visceral epithelial cell development (GO:0072015)2.24012300
161endothelium development (GO:0003158)2.23571691
162branching involved in salivary gland morphogenesis (GO:0060445)2.22027469
163neural crest cell development (GO:0014032)2.19212611
164cell junction organization (GO:0034330)2.16620565
165regulation of chondrocyte differentiation (GO:0032330)2.16542381
166developmental cell growth (GO:0048588)2.15443389
167muscle cell migration (GO:0014812)2.14398141
168regulation of hippo signaling (GO:0035330)2.14339702
169cochlea morphogenesis (GO:0090103)2.13878186
170non-canonical Wnt signaling pathway (GO:0035567)2.13037482
171adherens junction organization (GO:0034332)2.12331916
172mitotic cytokinesis (GO:0000281)2.11690357
173positive regulation of endothelial cell migration (GO:0010595)2.10510163
174cell-cell junction assembly (GO:0007043)2.10480215
175cytoskeleton-dependent cytokinesis (GO:0061640)2.09741778
176regulation of early endosome to late endosome transport (GO:2000641)2.08397883
177ephrin receptor signaling pathway (GO:0048013)2.07106896
178regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.06638098
179basement membrane organization (GO:0071711)2.05524505
180regulation of integrin-mediated signaling pathway (GO:2001044)2.04980482
181positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.03971892
182regulation of adherens junction organization (GO:1903391)2.03774149
183protein localization to cell surface (GO:0034394)2.03717520
184cell-substrate adherens junction assembly (GO:0007045)2.03234524
185focal adhesion assembly (GO:0048041)2.03234524
186regulation of cell-substrate junction assembly (GO:0090109)2.02880852
187regulation of focal adhesion assembly (GO:0051893)2.02880852
188negative regulation of fatty acid transport (GO:2000192)2.01529625

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.14213528
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.94354237
3GBX2_23144817_ChIP-Seq_PC3_Human2.65016322
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52242901
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.48637667
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45690081
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45690081
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.44029173
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.34461638
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27521778
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26906252
12* DROSHA_22980978_ChIP-Seq_HELA_Human2.20111824
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18604138
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.15018847
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13711306
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.13482243
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13033732
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.09776495
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09725357
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04743878
21CJUN_26792858_Chip-Seq_BT549_Human2.04073194
22* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.90502579
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89587710
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.89150561
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86666625
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.85652838
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77662438
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.77207435
29AR_21909140_ChIP-Seq_LNCAP_Human1.70406334
30* BRD4_25478319_ChIP-Seq_HGPS_Human1.69632938
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.68483406
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.67812976
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64847508
34SOX9_24532713_ChIP-Seq_HFSC_Mouse1.63587264
35SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.63108718
36SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.63108718
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61937318
38REST_21632747_ChIP-Seq_MESCs_Mouse1.61501356
39* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60683184
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.59031283
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58518276
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58154633
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57854949
44AR_21572438_ChIP-Seq_LNCaP_Human1.55780666
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50196975
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48511376
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47600205
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.45577019
49KDM2B_26808549_Chip-Seq_K562_Human1.44962103
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44657528
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.44399505
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44339167
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.43757912
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.43378969
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42786781
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42240634
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42240634
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42051939
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41165054
60* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.41062422
61* GATA2_21666600_ChIP-Seq_HMVEC_Human1.41048755
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.40948164
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36214956
64AHR_22903824_ChIP-Seq_MCF-7_Human1.35149527
65AR_19668381_ChIP-Seq_PC3_Human1.34938564
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34501003
67SMAD4_21799915_ChIP-Seq_A2780_Human1.34123172
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.32302079
69TP53_16413492_ChIP-PET_HCT116_Human1.32125566
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29774625
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29352115
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.29142897
73CLOCK_20551151_ChIP-Seq_293T_Human1.29109394
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29094950
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28719212
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.28455310
77FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27217304
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.26449717
79* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26365123
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.25139889
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23371954
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22974221
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22272770
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21927516
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21807255
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.20489240
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.19709031
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18892869
89STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18744881
90YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17682989
91* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17526023
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16274545
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16072261
94ISL1_27105846_Chip-Seq_CPCs_Mouse1.15193543
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.14825235
96STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14045753
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13334979
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.13124658
99ESR2_21235772_ChIP-Seq_MCF-7_Human1.13097707
100* CBX2_27304074_Chip-Seq_ESCs_Mouse1.12789588
101TCF4_18268006_ChIP-ChIP_LS174T_Human1.11698573
102ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11531870
103TP53_20018659_ChIP-ChIP_R1E_Mouse1.11516912
104* SMAD4_21741376_ChIP-Seq_HESCs_Human1.11450877
105ZNF274_21170338_ChIP-Seq_K562_Hela1.11161588
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.10911785
107TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10817995
108TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10354147
109SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10150304
110STAT3_23295773_ChIP-Seq_U87_Human1.09703052
111* TP63_23658742_ChIP-Seq_EP156T_Human1.09096895
112CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08484134
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08183757
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07976851
115* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07836949
116CDX2_20551321_ChIP-Seq_CACO-2_Human1.07731582
117TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05425044
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04998506
119EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04662412
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02613301
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02137688
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01579465
123SOX2_20726797_ChIP-Seq_SW620_Human1.01200336
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00805953
125RXR_22108803_ChIP-Seq_LS180_Human1.00624850
126PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00149995
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99960258
128* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99188211
129TP63_17297297_ChIP-ChIP_HaCaT_Human0.99176679
130ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99167832
131OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97772617
132UBF1/2_26484160_Chip-Seq_HMECs_Human0.97712455
133TP53_18474530_ChIP-ChIP_U2OS_Human0.97569022
134* AR_25329375_ChIP-Seq_VCAP_Human0.96047447
135* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95427065
136TAF15_26573619_Chip-Seq_HEK293_Human0.95282262
137NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94696261
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94561158
139P300_19829295_ChIP-Seq_ESCs_Human0.93969126
140ESR1_20079471_ChIP-ChIP_T-47D_Human0.93713772
141NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93595423
142KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93322615
143* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91953459
144FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91699477
145P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91649917
146TCF4_23295773_ChIP-Seq_U87_Human0.91365238
147BCAT_22108803_ChIP-Seq_LS180_Human0.90339356

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.67784362
2MP0008438_abnormal_cutaneous_collagen3.49090086
3MP0003635_abnormal_synaptic_transmissio2.76846846
4MP0003880_abnormal_central_pattern2.72398770
5MP0003283_abnormal_digestive_organ2.61828882
6MP0003566_abnormal_cell_adhesion2.55395160
7MP0005275_abnormal_skin_tensile2.53296640
8MP0002063_abnormal_learning/memory/cond2.34173503
9MP0004270_analgesia2.32461183
10MP0005409_darkened_coat_color2.26972315
11MP0003950_abnormal_plasma_membrane2.19553889
12MP0000778_abnormal_nervous_system2.18783371
13MP0001879_abnormal_lymphatic_vessel2.16385743
14MP0009780_abnormal_chondrocyte_physiolo2.15517855
15MP0000569_abnormal_digit_pigmentation2.09043101
16MP0003122_maternal_imprinting2.08628600
17MP0005623_abnormal_meninges_morphology2.06840506
18MP0005257_abnormal_intraocular_pressure2.05447746
19MP0005423_abnormal_somatic_nervous1.92714585
20MP0009745_abnormal_behavioral_response1.90396490
21MP0001486_abnormal_startle_reflex1.90313949
22MP0000579_abnormal_nail_morphology1.88732324
23MP0003787_abnormal_imprinting1.86978902
24MP0009046_muscle_twitch1.83626706
25MP0002064_seizures1.83531904
26MP0000537_abnormal_urethra_morphology1.83434523
27MP0000762_abnormal_tongue_morphology1.81749828
28MP0002572_abnormal_emotion/affect_behav1.76194447
29MP0002234_abnormal_pharynx_morphology1.72724630
30MP0003941_abnormal_skin_development1.64154159
31MP0004215_abnormal_myocardial_fiber1.63488406
32MP0010352_gastrointestinal_tract_polyps1.59721831
33MP0004858_abnormal_nervous_system1.57190609
34MP0002184_abnormal_innervation1.54430635
35MP0000751_myopathy1.51519171
36MP0005023_abnormal_wound_healing1.50123000
37MP0004233_abnormal_muscle_weight1.49570282
38MP0010030_abnormal_orbit_morphology1.47290738
39MP0003091_abnormal_cell_migration1.43885896
40MP0002909_abnormal_adrenal_gland1.43195910
41MP0010678_abnormal_skin_adnexa1.43146489
42MP0005187_abnormal_penis_morphology1.43044390
43MP0005248_abnormal_Harderian_gland1.42187904
44MP0001958_emphysema1.42168400
45MP0010368_abnormal_lymphatic_system1.41942910
46MP0003119_abnormal_digestive_system1.41724936
47MP0003137_abnormal_impulse_conducting1.39464185
48MP0002877_abnormal_melanocyte_morpholog1.38052802
49MP0002060_abnormal_skin_morphology1.37051374
50MP0003121_genomic_imprinting1.36846109
51MP0002734_abnormal_mechanical_nocicepti1.36249075
52MP0001501_abnormal_sleep_pattern1.35960217
53MP0001849_ear_inflammation1.35915793
54MP0000534_abnormal_ureter_morphology1.34106757
55MP0009384_cardiac_valve_regurgitation1.34022297
56MP0000467_abnormal_esophagus_morphology1.33738730
57MP0000383_abnormal_hair_follicle1.33691122
58MP0002653_abnormal_ependyma_morphology1.30234136
59MP0000955_abnormal_spinal_cord1.28566381
60MP0004811_abnormal_neuron_physiology1.28148244
61MP0002557_abnormal_social/conspecific_i1.28011336
62MP0003705_abnormal_hypodermis_morpholog1.27111287
63MP0003279_aneurysm1.27085760
64MP0004885_abnormal_endolymph1.25386486
65MP0002272_abnormal_nervous_system1.22479089
66MP0010234_abnormal_vibrissa_follicle1.22268123
67MP0000767_abnormal_smooth_muscle1.20353956
68MP0005503_abnormal_tendon_morphology1.20121858
69MP0002796_impaired_skin_barrier1.19388927
70MP0002067_abnormal_sensory_capabilities1.18579189
71MP0004084_abnormal_cardiac_muscle1.18438983
72MP0005167_abnormal_blood-brain_barrier1.18121108
73MP0002837_dystrophic_cardiac_calcinosis1.16808576
74MP0002089_abnormal_postnatal_growth/wei1.15974612
75MP0002697_abnormal_eye_size1.14896144
76MP0002735_abnormal_chemical_nociception1.14193206
77MP0002882_abnormal_neuron_morphology1.14144928
78MP0002152_abnormal_brain_morphology1.13803894
79MP0001968_abnormal_touch/_nociception1.13429245
80MP0005197_abnormal_uvea_morphology1.13281990
81MP0000432_abnormal_head_morphology1.12794280
82MP0005501_abnormal_skin_physiology1.12574208
83MP0004145_abnormal_muscle_electrophysio1.12297151
84MP0003385_abnormal_body_wall1.11604921
85MP0002733_abnormal_thermal_nociception1.11216930
86MP0001440_abnormal_grooming_behavior1.10248361
87MP0004484_altered_response_of1.10117112
88MP0002896_abnormal_bone_mineralization1.09704178
89MP0009053_abnormal_anal_canal1.09405863
90MP0004085_abnormal_heartbeat1.09402767
91MP0003115_abnormal_respiratory_system1.08889702
92MP0004272_abnormal_basement_membrane1.08513936
93MP0008961_abnormal_basal_metabolism1.07735618
94MP0008569_lethality_at_weaning1.07444713
95MP0005645_abnormal_hypothalamus_physiol1.07342940
96MP0000733_abnormal_muscle_development1.06992758
97MP0003890_abnormal_embryonic-extraembry1.06776737
98MP0003861_abnormal_nervous_system1.05616661
99MP0001502_abnormal_circadian_rhythm1.05527875
100MP0005394_taste/olfaction_phenotype1.01583548
101MP0005499_abnormal_olfactory_system1.01583548
102MP0000462_abnormal_digestive_system1.00395611
103MP0003935_abnormal_craniofacial_develop0.99159936
104MP0003942_abnormal_urinary_system0.98403456
105MP0005646_abnormal_pituitary_gland0.97613828
106MP0001299_abnormal_eye_distance/0.97473025
107MP0004924_abnormal_behavior0.96782375
108MP0005386_behavior/neurological_phenoty0.96782375
109MP0003123_paternal_imprinting0.96411774
110MP0006054_spinal_hemorrhage0.96144077
111MP0005551_abnormal_eye_electrophysiolog0.96114341
112MP0000566_synostosis0.95346506
113MP0001984_abnormal_olfaction0.94956987
114MP0003045_fibrosis0.94105317
115MP0006072_abnormal_retinal_apoptosis0.92408175
116MP0001970_abnormal_pain_threshold0.92341321
117MP0002092_abnormal_eye_morphology0.91610211
118MP0002116_abnormal_craniofacial_bone0.90551285
119MP0001286_abnormal_eye_development0.88597219
120MP0003868_abnormal_feces_composition0.88590416
121MP0005171_absent_coat_pigmentation0.87133096
122MP0000516_abnormal_urinary_system0.86570787
123MP0005367_renal/urinary_system_phenotyp0.86570787
124MP0002084_abnormal_developmental_patter0.86525001
125MP0010771_integument_phenotype0.86275014
126MP0005595_abnormal_vascular_smooth0.86021285
127MP0002925_abnormal_cardiovascular_devel0.85655086
128MP0000049_abnormal_middle_ear0.85409331
129MP0002066_abnormal_motor_capabilities/c0.85319358
130MP0005508_abnormal_skeleton_morphology0.85231347
131MP0003453_abnormal_keratinocyte_physiol0.84871458
132MP0000631_abnormal_neuroendocrine_gland0.83616578
133MP0003755_abnormal_palate_morphology0.83562708
134MP0005076_abnormal_cell_differentiation0.82827783
135MP0002249_abnormal_larynx_morphology0.82085336
136MP0002233_abnormal_nose_morphology0.81948373
137MP0005620_abnormal_muscle_contractility0.81638728
138MP0002295_abnormal_pulmonary_circulatio0.81130315
139MP0000428_abnormal_craniofacial_morphol0.79986400
140MP0002282_abnormal_trachea_morphology0.79633902
141MP0002098_abnormal_vibrissa_morphology0.79629937
142MP0000647_abnormal_sebaceous_gland0.78752262
143MP0006138_congestive_heart_failure0.77831914
144MP0008775_abnormal_heart_ventricle0.77787476
145MP0001340_abnormal_eyelid_morphology0.77288771
146MP0003937_abnormal_limbs/digits/tail_de0.77130013
147MP0003329_amyloid_beta_deposits0.77083596
148MP0000163_abnormal_cartilage_morphology0.77056647
149MP0009250_abnormal_appendicular_skeleto0.76980304
150MP0002085_abnormal_embryonic_tissue0.76199620
151MP0002081_perinatal_lethality0.75755869
152MP0004134_abnormal_chest_morphology0.73789568
153MP0001614_abnormal_blood_vessel0.73036232
154MP0002177_abnormal_outer_ear0.72617817
155MP0002932_abnormal_joint_morphology0.72566372
156MP0002938_white_spotting0.72473028
157MP0000377_abnormal_hair_follicle0.71838565
158MP0001216_abnormal_epidermal_layer0.71268052
159MP0002128_abnormal_blood_circulation0.71237695
160MP0003315_abnormal_perineum_morphology0.70380839
161MP0000427_abnormal_hair_cycle0.70305193

Predicted human phenotypes

RankGene SetZ-score
1Arterial tortuosity (HP:0005116)3.91629261
2Premature rupture of membranes (HP:0001788)3.90815119
3Protrusio acetabuli (HP:0003179)3.87439953
4Atrophic scars (HP:0001075)3.80501184
5Vascular tortuosity (HP:0004948)3.69236600
6Focal motor seizures (HP:0011153)3.55083239
7Myokymia (HP:0002411)3.37641938
8Progressive cerebellar ataxia (HP:0002073)3.24862982
9Focal seizures (HP:0007359)3.15166193
10Aortic dissection (HP:0002647)3.09072368
11Epileptic encephalopathy (HP:0200134)3.01205381
12Aortic aneurysm (HP:0004942)2.80391643
13Neonatal short-limb short stature (HP:0008921)2.79732345
14Febrile seizures (HP:0002373)2.78557621
15Genetic anticipation (HP:0003743)2.72110285
16Cervical subluxation (HP:0003308)2.69445134
17Visual hallucinations (HP:0002367)2.66044484
18Short nail (HP:0001799)2.63425428
19Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.53610067
20Fragile skin (HP:0001030)2.51782315
21Action tremor (HP:0002345)2.43962417
22Renal duplication (HP:0000075)2.42599581
23Ankle contracture (HP:0006466)2.38422984
24Milia (HP:0001056)2.35615718
25Soft skin (HP:0000977)2.28182255
26Shallow orbits (HP:0000586)2.27439502
27Dysmetric saccades (HP:0000641)2.22448169
28Hyperacusis (HP:0010780)2.22135324
29Broad-based gait (HP:0002136)2.21661513
30Elfin facies (HP:0004428)2.20802813
31Abnormality of the distal phalanx of the thumb (HP:0009617)2.17936557
32Wormian bones (HP:0002645)2.16454560
33Megalencephaly (HP:0001355)2.16118577
34Hemiplegia (HP:0002301)2.14573283
35Abnormality of the astrocytes (HP:0100707)2.14435530
36Astrocytoma (HP:0009592)2.14435530
37Thick nail (HP:0001805)2.14403661
38Pterygium (HP:0001059)2.14039254
39Bladder diverticulum (HP:0000015)2.13876189
40Pointed chin (HP:0000307)2.12612415
41Drooling (HP:0002307)2.12360140
42Excessive salivation (HP:0003781)2.12360140
43Ventricular fibrillation (HP:0001663)2.12271438
44Syncope (HP:0001279)2.11918375
45Prolonged QT interval (HP:0001657)2.09936610
46Hepatoblastoma (HP:0002884)2.09756050
47Absence seizures (HP:0002121)2.09010439
48Macroorchidism (HP:0000053)2.07572012
49Tibial bowing (HP:0002982)2.07186121
50Obsessive-compulsive behavior (HP:0000722)2.06678009
51Insomnia (HP:0100785)2.05169371
52Fragile nails (HP:0001808)2.04298748
53Sudden death (HP:0001699)2.04245184
54Right ventricular cardiomyopathy (HP:0011663)2.03471507
55Renovascular hypertension (HP:0100817)2.02891181
56Mitral valve prolapse (HP:0001634)2.01895758
57Spinal rigidity (HP:0003306)2.01595843
58Dysdiadochokinesis (HP:0002075)2.00377809
59Impaired social interactions (HP:0000735)1.99844589
60Abnormal social behavior (HP:0012433)1.99844589
61Hemiparesis (HP:0001269)1.99396075
62Short 4th metacarpal (HP:0010044)1.97857276
63Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97857276
64Natal tooth (HP:0000695)1.97178445
65Turricephaly (HP:0000262)1.95114696
66Broad metatarsal (HP:0001783)1.94224702
67Wide anterior fontanel (HP:0000260)1.92902278
68Amblyopia (HP:0000646)1.92855219
69Advanced eruption of teeth (HP:0006288)1.92201096
70Abnormality of dentin (HP:0010299)1.91811771
71Coronal craniosynostosis (HP:0004440)1.90717765
72Depression (HP:0000716)1.89169287
73Abnormality of the lower motor neuron (HP:0002366)1.88677459
74Neoplasm of the heart (HP:0100544)1.88567175
75Joint laxity (HP:0001388)1.87689867
76Onycholysis (HP:0001806)1.86862708
77Broad face (HP:0000283)1.86272955
78Exotropia (HP:0000577)1.85947150
79Lymphangioma (HP:0100764)1.85774485
80Bundle branch block (HP:0011710)1.84351725
81Aqueductal stenosis (HP:0002410)1.83554958
82Cerebral aneurysm (HP:0004944)1.82673664
83Primary atrial arrhythmia (HP:0001692)1.82551789
84Poor eye contact (HP:0000817)1.81591753
85Narrow palate (HP:0000189)1.79966615
86Flat acetabular roof (HP:0003180)1.79834275
87Atrial fibrillation (HP:0005110)1.79675173
88Abnormal EKG (HP:0003115)1.79468921
89Reduced subcutaneous adipose tissue (HP:0003758)1.79197670
90Osteolytic defects of the phalanges of the hand (HP:0009771)1.78223434
91Osteolytic defects of the hand bones (HP:0009699)1.78223434
92Broad thumb (HP:0011304)1.77931239
93Hyperventilation (HP:0002883)1.77150097
94Increased mean platelet volume (HP:0011877)1.76583424
95Overgrowth (HP:0001548)1.75637862
96Termporal pattern (HP:0011008)1.74893642
97Insidious onset (HP:0003587)1.74893642
98Glioma (HP:0009733)1.73800959
99Bronchomalacia (HP:0002780)1.73781077
100Trigonocephaly (HP:0000243)1.73676231
101Spinal cord compression (HP:0002176)1.73363799
102Disproportionate tall stature (HP:0001519)1.73172511
103Vertebral arch anomaly (HP:0008438)1.72450413
104Abnormality of the pubic bones (HP:0003172)1.72429989
105Follicular hyperkeratosis (HP:0007502)1.72073922
106Flat cornea (HP:0007720)1.71467824
107Dialeptic seizures (HP:0011146)1.71235377
108Overriding aorta (HP:0002623)1.70913638
109Thin bony cortex (HP:0002753)1.70377858
110Hypoplasia of the iris (HP:0007676)1.70068340
111Tented upper lip vermilion (HP:0010804)1.69621722
112Mildly elevated creatine phosphokinase (HP:0008180)1.69540263
113Hypoplastic ischia (HP:0003175)1.69358569
114Oligodactyly (hands) (HP:0001180)1.69317195
115Abnormal auditory evoked potentials (HP:0006958)1.69296817
116Supraventricular arrhythmia (HP:0005115)1.68621798
117Narrow nasal bridge (HP:0000446)1.68090776
118Heterotopia (HP:0002282)1.68061558
119Atonic seizures (HP:0010819)1.66638622
120Generalized tonic-clonic seizures (HP:0002069)1.65710362
121Cardiovascular calcification (HP:0011915)1.65581858
122Abnormality of the phalanges of the hallux (HP:0010057)1.65215634
123Focal segmental glomerulosclerosis (HP:0000097)1.65196308
124Supraventricular tachycardia (HP:0004755)1.65083919
125Ankyloglossia (HP:0010296)1.64394821
126Impaired vibration sensation in the lower limbs (HP:0002166)1.63808687
127Epileptiform EEG discharges (HP:0011182)1.62888825
128Truncal ataxia (HP:0002078)1.62430086
129Vitreoretinal degeneration (HP:0000655)1.62250104
130Urinary bladder sphincter dysfunction (HP:0002839)1.62171762
131Asymmetry of the thorax (HP:0001555)1.61876560
132Spinal cord lesions (HP:0100561)1.61575862
133Syringomyelia (HP:0003396)1.61575862
134Aplasia involving bones of the upper limbs (HP:0009823)1.61446684
135Aplasia of the phalanges of the hand (HP:0009802)1.61446684
136Aplasia involving bones of the extremities (HP:0009825)1.61446684
137Absent frontal sinuses (HP:0002688)1.61075990
138Abnormal ossification of hand bones (HP:0005921)1.60885900
139Open mouth (HP:0000194)1.60319440
140Abnormality of the 4th metacarpal (HP:0010012)1.59931848
141Midline defect of the nose (HP:0004122)1.59706640
142Hyperextensible skin (HP:0000974)1.59566894
143Central scotoma (HP:0000603)1.59504378
144Abnormality of the acetabulum (HP:0003170)1.59158647
145Urethral obstruction (HP:0000796)1.58564488
146Mitral stenosis (HP:0001718)1.58056375
147Ulnar bowing (HP:0003031)1.58008274
148Arnold-Chiari malformation (HP:0002308)1.57758509
149Buphthalmos (HP:0000557)1.57708691
150Gaze-evoked nystagmus (HP:0000640)1.57670813
151Autism (HP:0000717)1.57143933
152High anterior hairline (HP:0009890)1.57108328
153Annular pancreas (HP:0001734)1.56894963
154Limited hip movement (HP:0008800)1.56869205
155Microglossia (HP:0000171)1.56577079
156Wrist flexion contracture (HP:0001239)1.56574750
157EEG with generalized epileptiform discharges (HP:0011198)1.56120042
158Abnormal eating behavior (HP:0100738)1.55658214
159Abnormality of the aortic arch (HP:0012303)1.55558824
160Cutaneous finger syndactyly (HP:0010554)1.55210546
161Postural instability (HP:0002172)1.54763567
162Stereotypic behavior (HP:0000733)1.53838887
163Bowel diverticulosis (HP:0005222)1.52990054
164Anophthalmia (HP:0000528)1.52360233
165Genu recurvatum (HP:0002816)1.52346520
166Impaired smooth pursuit (HP:0007772)1.52117747
167Ventricular arrhythmia (HP:0004308)1.51582106
168Papillary thyroid carcinoma (HP:0002895)1.50948124
169Pulmonic stenosis (HP:0001642)1.50704148
170Striae distensae (HP:0001065)1.49954891
171Distal upper limb amyotrophy (HP:0007149)1.49919455
172Upper limb amyotrophy (HP:0009129)1.49919455
173Abnormality of carpal bone ossification (HP:0006257)1.49866482
174Hypopigmentation of the fundus (HP:0007894)1.47852151
175Enlarged penis (HP:0000040)1.47498933
176Menorrhagia (HP:0000132)1.47497356
177Blue sclerae (HP:0000592)1.46625289
178Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.44667660
179Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.44282158
180Aortic regurgitation (HP:0001659)1.44184444
181Distal lower limb amyotrophy (HP:0008944)1.43529084
182Hypoplastic labia majora (HP:0000059)1.42894117
183Mitral regurgitation (HP:0001653)1.42887058
184Vertebral clefting (HP:0008428)1.42856500
185Dilatation of the ascending aorta (HP:0005111)1.41423472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MET3.34893297
2MST1R3.34198930
3EPHA23.28282431
4EPHA43.13995460
5NTRK32.99318741
6MARK12.63887612
7PAK62.54257580
8INSRR2.51811393
9MAP3K42.44343597
10EPHB22.43446765
11KSR12.20542356
12MAP3K92.15489360
13RIPK12.08421498
14MINK11.88987465
15CAMK1G1.79162623
16NTRK21.74600595
17TRIM281.71921879
18LATS11.70758991
19PRKD31.66353828
20DMPK1.63021017
21DAPK21.63005960
22STK38L1.61907436
23SIK21.61167348
24SIK31.57783046
25LMTK21.55197125
26FER1.52908156
27ICK1.50597451
28CAMK1D1.46335888
29LATS21.43476124
30MYLK1.38587910
31DDR21.37023057
32PHKG11.36203954
33PHKG21.36203954
34TYRO31.35184589
35PAK41.33589704
36PAK31.33438485
37STK241.33154688
38STK391.31725021
39MAP2K71.31534629
40ERBB41.28867151
41CAMKK11.26408433
42PDGFRA1.25406253
43STK381.23956422
44STK31.20313556
45PKN21.19342557
46MAP2K41.19033365
47BRD41.17393678
48CDK51.16419372
49CDK121.14798072
50TGFBR21.13033287
51ERBB21.09969366
52MOS1.08934555
53MAP3K61.08867494
54KSR21.08068530
55CDK81.02961148
56TAOK11.02537748
57NTRK11.01433562
58UHMK11.01103025
59SGK31.00070284
60NEK90.99029646
61SIK10.98196737
62TRIB30.97743432
63PLK20.96361107
64PAK20.93999014
65TGFBR10.92252274
66CDC42BPA0.91051203
67ILK0.90855260
68DAPK10.88692961
69DYRK1A0.88504100
70MAP3K70.88335022
71SGK4940.88215057
72SGK2230.88215057
73NEK10.86943869
74FGFR10.85577511
75SGK20.85173128
76ALK0.84457988
77BMX0.83701701
78PTK20.82717856
79RET0.81822385
80WNK30.81323171
81PBK0.81225378
82MAPK130.81058930
83FLT30.80964558
84ERBB30.79899148
85SGK10.79362164
86PNCK0.78100087
87PRKCG0.75537855
88CASK0.75095851
89PTK60.73913081
90MAP3K100.73600865
91CAMK2A0.73597304
92CAMK10.72558856
93PRKCH0.71159222
94IRAK30.71075864
95RPS6KA20.70976058
96CAMK40.70379091
97PTK2B0.69975680
98STK110.69816827
99ROCK10.68581829
100FGFR20.68369804
101AKT30.66081912
102GRK50.65470695
103MAPK100.65440569
104LIMK10.65026830
105PRKCZ0.64917601
106MAP3K20.64530500
107TESK10.64440911
108CDK180.64301772
109PIK3CA0.63465589
110BCR0.62618655
111CAMK2B0.61634833
112WNK10.60084399
113TIE10.58754287
114CDK150.58013616
115TRPM70.57540106
116RPS6KA30.56282556
117PRKAA10.56101085
118MTOR0.55949937
119MAP3K120.55725665
120AKT20.55206999
121MELK0.54063691
122CAMK2D0.53785079
123CDK140.53031310
124WNK40.51189668
125MARK20.50756720
126CDK90.49325900
127CDK11A0.49275969
128MAPK90.48776571
129BMPR1B0.47899156
130MAP2K10.46272748
131TTN0.45669511
132TNIK0.45483381
133ARAF0.45413663
134EEF2K0.45280482
135ROCK20.45236677
136PRKCE0.44637165
137RIPK40.44061282
138PDGFRB0.43739940
139NEK20.40012279
140GSK3A0.38335206
141BRSK20.34567056
142CAMK2G0.34058570
143BRSK10.31012730
144PRKG20.29779614
145SCYL20.29025159
146MUSK0.28428765

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.64245486
2Circadian entrainment_Homo sapiens_hsa047132.34647601
3Long-term potentiation_Homo sapiens_hsa047202.14209200
4Glutamatergic synapse_Homo sapiens_hsa047242.08632260
5GABAergic synapse_Homo sapiens_hsa047272.04166776
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96029491
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95297407
8Salivary secretion_Homo sapiens_hsa049701.92446145
9Nitrogen metabolism_Homo sapiens_hsa009101.80733088
10Morphine addiction_Homo sapiens_hsa050321.79474259
11Insulin secretion_Homo sapiens_hsa049111.77678866
12Amphetamine addiction_Homo sapiens_hsa050311.71651083
13Gastric acid secretion_Homo sapiens_hsa049711.71159812
14Olfactory transduction_Homo sapiens_hsa047401.70901924
15Synaptic vesicle cycle_Homo sapiens_hsa047211.68998761
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62860485
17Small cell lung cancer_Homo sapiens_hsa052221.60319528
18Dopaminergic synapse_Homo sapiens_hsa047281.57278256
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56163400
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.55320582
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53192389
22Dilated cardiomyopathy_Homo sapiens_hsa054141.52672796
23Axon guidance_Homo sapiens_hsa043601.52368158
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51071003
25TGF-beta signaling pathway_Homo sapiens_hsa043501.49810125
26Cholinergic synapse_Homo sapiens_hsa047251.48141931
27Renin secretion_Homo sapiens_hsa049241.47044265
28Oxytocin signaling pathway_Homo sapiens_hsa049211.46742948
29Gap junction_Homo sapiens_hsa045401.45253527
30Taste transduction_Homo sapiens_hsa047421.38583960
31Long-term depression_Homo sapiens_hsa047301.37791175
32Dorso-ventral axis formation_Homo sapiens_hsa043201.37547027
33GnRH signaling pathway_Homo sapiens_hsa049121.34896037
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.33775032
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32804967
36Melanogenesis_Homo sapiens_hsa049161.29715221
37Thyroid cancer_Homo sapiens_hsa052161.27008329
38cAMP signaling pathway_Homo sapiens_hsa040241.22893077
39Amoebiasis_Homo sapiens_hsa051461.22171080
40Calcium signaling pathway_Homo sapiens_hsa040201.19418966
41Type II diabetes mellitus_Homo sapiens_hsa049301.18947721
42Glioma_Homo sapiens_hsa052141.18878755
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15438751
44PI3K-Akt signaling pathway_Homo sapiens_hsa041511.14787965
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.14583062
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14447881
47Basal cell carcinoma_Homo sapiens_hsa052171.14260856
48Chronic myeloid leukemia_Homo sapiens_hsa052201.13051998
49Serotonergic synapse_Homo sapiens_hsa047261.12967170
50Melanoma_Homo sapiens_hsa052181.12048372
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12000682
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11140894
53Estrogen signaling pathway_Homo sapiens_hsa049151.11009164
54Hippo signaling pathway_Homo sapiens_hsa043901.10650946
55Wnt signaling pathway_Homo sapiens_hsa043101.10227506
56ErbB signaling pathway_Homo sapiens_hsa040121.08633010
57Hedgehog signaling pathway_Homo sapiens_hsa043401.06685821
58Circadian rhythm_Homo sapiens_hsa047101.03550680
59Cocaine addiction_Homo sapiens_hsa050301.03250414
60Adherens junction_Homo sapiens_hsa045201.01416123
61Endometrial cancer_Homo sapiens_hsa052130.99921821
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99076794
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96625078
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95307698
65Bile secretion_Homo sapiens_hsa049760.93826398
66Pancreatic cancer_Homo sapiens_hsa052120.91816924
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90360092
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89767301
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.87952353
70mTOR signaling pathway_Homo sapiens_hsa041500.85640213
71Choline metabolism in cancer_Homo sapiens_hsa052310.85142980
72Rap1 signaling pathway_Homo sapiens_hsa040150.84490166
73Thyroid hormone synthesis_Homo sapiens_hsa049180.83602962
74Pancreatic secretion_Homo sapiens_hsa049720.83430349
75Proteoglycans in cancer_Homo sapiens_hsa052050.82659489
76Tight junction_Homo sapiens_hsa045300.81700866
77Focal adhesion_Homo sapiens_hsa045100.80078620
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79927540
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.78234322
80Prostate cancer_Homo sapiens_hsa052150.78127215
81VEGF signaling pathway_Homo sapiens_hsa043700.76508500
82Platelet activation_Homo sapiens_hsa046110.75606838
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75344362
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74074660
85Oocyte meiosis_Homo sapiens_hsa041140.73731527
86Fatty acid biosynthesis_Homo sapiens_hsa000610.73343652
87Glucagon signaling pathway_Homo sapiens_hsa049220.72209015
88AMPK signaling pathway_Homo sapiens_hsa041520.71965015
89ECM-receptor interaction_Homo sapiens_hsa045120.70541138
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69961128
91* Endocytosis_Homo sapiens_hsa041440.69512807
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69335205
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.68305880
94Renal cell carcinoma_Homo sapiens_hsa052110.68184207
95MAPK signaling pathway_Homo sapiens_hsa040100.67606215
96Prion diseases_Homo sapiens_hsa050200.67306856
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66000279
98Colorectal cancer_Homo sapiens_hsa052100.64795743
99Cell cycle_Homo sapiens_hsa041100.64422962
100Notch signaling pathway_Homo sapiens_hsa043300.63784306
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63638684
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.63098307
103Cardiac muscle contraction_Homo sapiens_hsa042600.61642934
104Non-small cell lung cancer_Homo sapiens_hsa052230.60037049
105Phototransduction_Homo sapiens_hsa047440.59902819
106p53 signaling pathway_Homo sapiens_hsa041150.59311445
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.58936914
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58889429
109Insulin signaling pathway_Homo sapiens_hsa049100.57542511
110MicroRNAs in cancer_Homo sapiens_hsa052060.57333779
111Ras signaling pathway_Homo sapiens_hsa040140.56147057
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55573213
113Lysine degradation_Homo sapiens_hsa003100.55356791
114Steroid biosynthesis_Homo sapiens_hsa001000.53848411
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53129082
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52998577
117Arginine biosynthesis_Homo sapiens_hsa002200.52910860
118Protein digestion and absorption_Homo sapiens_hsa049740.52895125
119Vibrio cholerae infection_Homo sapiens_hsa051100.50604255
120Bladder cancer_Homo sapiens_hsa052190.50032882
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49359383
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49054868
123Inositol phosphate metabolism_Homo sapiens_hsa005620.45533604
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44886895
125Pathways in cancer_Homo sapiens_hsa052000.44584597

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