ASAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)4.62358708
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.62358708
3L-phenylalanine metabolic process (GO:0006558)4.56945290
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.56945290
5paraxial mesoderm development (GO:0048339)4.40397247
6alpha-linolenic acid metabolic process (GO:0036109)4.36485863
7protein carboxylation (GO:0018214)4.27494548
8peptidyl-glutamic acid carboxylation (GO:0017187)4.27494548
9negative regulation of fibrinolysis (GO:0051918)4.14443990
10glyoxylate metabolic process (GO:0046487)3.97145173
11sulfur amino acid catabolic process (GO:0000098)3.94881455
12regulation of protein activation cascade (GO:2000257)3.90015210
13aromatic amino acid family catabolic process (GO:0009074)3.89833749
14fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.82491765
15regulation of fibrinolysis (GO:0051917)3.78873746
16planar cell polarity pathway involved in neural tube closure (GO:0090179)3.73022303
17regulation of complement activation (GO:0030449)3.70356051
18urea metabolic process (GO:0019627)3.63696912
19urea cycle (GO:0000050)3.63696912
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.56006374
21complement activation, alternative pathway (GO:0006957)3.54602532
22nitrogen cycle metabolic process (GO:0071941)3.50050838
23regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.48451902
24bile acid biosynthetic process (GO:0006699)3.47486931
25kynurenine metabolic process (GO:0070189)3.46715765
26cellular modified amino acid catabolic process (GO:0042219)3.42108478
27positive regulation of fatty acid beta-oxidation (GO:0032000)3.41003818
28triglyceride homeostasis (GO:0070328)3.33523847
29acylglycerol homeostasis (GO:0055090)3.33523847
30indolalkylamine catabolic process (GO:0046218)3.31935470
31tryptophan catabolic process (GO:0006569)3.31935470
32indole-containing compound catabolic process (GO:0042436)3.31935470
33lysine metabolic process (GO:0006553)3.26929219
34lysine catabolic process (GO:0006554)3.26929219
35coenzyme catabolic process (GO:0009109)3.21766691
36homocysteine metabolic process (GO:0050667)3.15537273
37bile acid metabolic process (GO:0008206)3.14347776
38cysteine metabolic process (GO:0006534)3.10495351
39amino-acid betaine metabolic process (GO:0006577)3.08540086
40serine family amino acid catabolic process (GO:0009071)3.08287561
41regulation of plasminogen activation (GO:0010755)3.07491173
42high-density lipoprotein particle remodeling (GO:0034375)3.07320762
43plasma lipoprotein particle clearance (GO:0034381)3.07209415
44collagen fibril organization (GO:0030199)3.06629361
45tryptophan metabolic process (GO:0006568)3.06376742
46regulation of cholesterol homeostasis (GO:2000188)3.03347038
47convergent extension (GO:0060026)3.03292265
48negative regulation of sterol transport (GO:0032372)3.02177893
49negative regulation of cholesterol transport (GO:0032375)3.02177893
50bile acid and bile salt transport (GO:0015721)3.02162628
51acetyl-CoA metabolic process (GO:0006084)3.01280065
52regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.00707728
53fatty acid beta-oxidation (GO:0006635)2.99806509
54notochord development (GO:0030903)2.97788847
55bone trabecula formation (GO:0060346)2.97769189
56neuron projection extension involved in neuron projection guidance (GO:1902284)2.97523098
57axon extension involved in axon guidance (GO:0048846)2.97523098
58regulation of triglyceride catabolic process (GO:0010896)2.96549791
59fibrinolysis (GO:0042730)2.93906821
60epoxygenase P450 pathway (GO:0019373)2.91789938
61desmosome organization (GO:0002934)2.89073239
62phospholipid homeostasis (GO:0055091)2.88600107
63alpha-amino acid catabolic process (GO:1901606)2.85041477
64Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.85006468
65fatty acid oxidation (GO:0019395)2.84285062
66cardiac myofibril assembly (GO:0055003)2.82990471
67negative regulation of chondrocyte differentiation (GO:0032331)2.81544130
68regulation of fatty acid beta-oxidation (GO:0031998)2.80881797
69cellular amino acid catabolic process (GO:0009063)2.79530995
70reverse cholesterol transport (GO:0043691)2.78445097
71hemidesmosome assembly (GO:0031581)2.76145011
72lipid oxidation (GO:0034440)2.76011526
73positive regulation of fatty acid oxidation (GO:0046321)2.75605530
74regulation of establishment of planar polarity (GO:0090175)2.73877347
75fatty acid catabolic process (GO:0009062)2.72492922
76negative regulation of protein activation cascade (GO:2000258)2.72174586
77apoptotic cell clearance (GO:0043277)2.71756217
78embryonic camera-type eye development (GO:0031076)2.70728373
79fatty acid transmembrane transport (GO:1902001)2.69745405
80ethanol oxidation (GO:0006069)2.69218950
81dicarboxylic acid biosynthetic process (GO:0043650)2.69136451
82aspartate family amino acid catabolic process (GO:0009068)2.68383136
83glomerular basement membrane development (GO:0032836)2.67898952
84negative regulation of lipase activity (GO:0060192)2.67693985
85aromatic amino acid family metabolic process (GO:0009072)2.65961012
86basement membrane organization (GO:0071711)2.64971011
87monocarboxylic acid catabolic process (GO:0072329)2.64098577
88epithelial cell-cell adhesion (GO:0090136)2.62847678
89non-canonical Wnt signaling pathway (GO:0035567)2.62671046
902-oxoglutarate metabolic process (GO:0006103)2.62252197
91carnitine shuttle (GO:0006853)2.59911883
92positive regulation of lipid catabolic process (GO:0050996)2.59003096
93bundle of His cell to Purkinje myocyte communication (GO:0086069)2.58735152
94positive regulation of triglyceride metabolic process (GO:0090208)2.58529648
95glycine metabolic process (GO:0006544)2.58055701
96complement activation, classical pathway (GO:0006958)2.57850760
97fatty acid homeostasis (GO:0055089)2.57427344
98hippo signaling (GO:0035329)2.57148027
99cholesterol homeostasis (GO:0042632)2.57035910
100glutamate metabolic process (GO:0006536)2.56887796
101cochlea morphogenesis (GO:0090103)2.56552296
102regulation of cardioblast differentiation (GO:0051890)2.56462385
103establishment of apical/basal cell polarity (GO:0035089)2.55854226
104positive regulation of smoothened signaling pathway (GO:0045880)2.55523863
105carboxylic acid catabolic process (GO:0046395)2.54864579
106organic acid catabolic process (GO:0016054)2.54864579
107tyrosine metabolic process (GO:0006570)2.54561896
108biotin metabolic process (GO:0006768)2.53615407
109sterol homeostasis (GO:0055092)2.52467693
110positive regulation of triglyceride biosynthetic process (GO:0010867)2.52165608
111polarized epithelial cell differentiation (GO:0030859)2.51409482
112hormone catabolic process (GO:0042447)2.50719010
113regulation of triglyceride metabolic process (GO:0090207)2.50459595
114very long-chain fatty acid metabolic process (GO:0000038)2.50427514
115G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.50389551
116regulation of triglyceride biosynthetic process (GO:0010866)2.50151055
117imidazole-containing compound metabolic process (GO:0052803)2.50073010
118response to mercury ion (GO:0046689)2.49369243
119positive regulation of SMAD protein import into nucleus (GO:0060391)2.49144843
120extracellular matrix assembly (GO:0085029)2.49026186
121short-chain fatty acid metabolic process (GO:0046459)2.48399325
122protein heterotrimerization (GO:0070208)2.48170196
123positive regulation of fatty acid biosynthetic process (GO:0045723)2.47851455
124extracellular fibril organization (GO:0043206)2.47159924
125myelination in peripheral nervous system (GO:0022011)2.46546827
126peripheral nervous system axon ensheathment (GO:0032292)2.46546827
127complement activation (GO:0006956)2.46376492
128plasma lipoprotein particle remodeling (GO:0034369)2.46147636
129macromolecular complex remodeling (GO:0034367)2.46147636
130sequestering of extracellular ligand from receptor (GO:0035581)2.45446110
131negative regulation of protein localization to cell surface (GO:2000009)2.38227716
132myofibril assembly (GO:0030239)2.36732003
133establishment of tissue polarity (GO:0007164)2.35484453
134establishment of planar polarity (GO:0001736)2.35484453
135lung-associated mesenchyme development (GO:0060484)2.35259378
136embryonic foregut morphogenesis (GO:0048617)2.34925511
137establishment of monopolar cell polarity (GO:0061162)2.33426659
138establishment or maintenance of monopolar cell polarity (GO:0061339)2.33426659
139retina vasculature morphogenesis in camera-type eye (GO:0061299)2.31910473
140outer ear morphogenesis (GO:0042473)2.30682717
141lateral sprouting from an epithelium (GO:0060601)2.29874975
142plasma membrane repair (GO:0001778)2.29057868
143regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.28226208
144establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.27560185
145camera-type eye morphogenesis (GO:0048593)2.27451556
146cytoskeletal anchoring at plasma membrane (GO:0007016)2.24626972
147positive regulation of catenin import into nucleus (GO:0035413)2.24539933
148anterior/posterior axis specification, embryo (GO:0008595)2.24110443
149collagen metabolic process (GO:0032963)2.23211305
150endothelial cell morphogenesis (GO:0001886)2.22870217
151negative regulation of cartilage development (GO:0061037)2.21185876
152chondrocyte proliferation (GO:0035988)2.19874570
153glomerular visceral epithelial cell development (GO:0072015)2.18747322
154regulation of axon extension involved in axon guidance (GO:0048841)2.18542786
155metanephric mesenchyme development (GO:0072075)2.15758116
156adherens junction assembly (GO:0034333)2.15485262
157organ induction (GO:0001759)2.14715612
158actomyosin structure organization (GO:0031032)2.14712036
159negative regulation of catenin import into nucleus (GO:0035414)2.13592788
160apical protein localization (GO:0045176)2.13108975
161establishment or maintenance of bipolar cell polarity (GO:0061245)2.12684318
162establishment or maintenance of apical/basal cell polarity (GO:0035088)2.12684318
163skin morphogenesis (GO:0043589)2.12228022
164positive regulation of mesenchymal cell proliferation (GO:0002053)2.11855130
165regulation of hippo signaling (GO:0035330)2.11728592
166branching involved in salivary gland morphogenesis (GO:0060445)2.11660489
167neuromuscular junction development (GO:0007528)2.10632532
168vascular endothelial growth factor signaling pathway (GO:0038084)2.10226333
169multicellular organismal macromolecule metabolic process (GO:0044259)2.09213813
170dorsal/ventral axis specification (GO:0009950)2.08897476
171axon extension (GO:0048675)2.06691519
172regulation of catenin import into nucleus (GO:0035412)2.06208282
173negative regulation of axon extension involved in axon guidance (GO:0048843)2.05951375
174regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.05416728
175postsynaptic membrane organization (GO:0001941)2.05314238
176semaphorin-plexin signaling pathway (GO:0071526)2.04979081
177collagen catabolic process (GO:0030574)2.04700614
178mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.04464770
179sarcomere organization (GO:0045214)2.03907772
180response to follicle-stimulating hormone (GO:0032354)2.03843972
181gap junction assembly (GO:0016264)2.03135987
182substrate adhesion-dependent cell spreading (GO:0034446)2.03082417
183atrioventricular valve morphogenesis (GO:0003181)2.02758305
184actin-myosin filament sliding (GO:0033275)2.02174961
185muscle filament sliding (GO:0030049)2.02174961
186regulation of axon guidance (GO:1902667)2.02140267
187glomerular epithelial cell development (GO:0072310)2.02107305
188regulation of mesenchymal cell proliferation (GO:0010464)2.01199116
189protein localization to cell surface (GO:0034394)2.00754117
190cell migration involved in sprouting angiogenesis (GO:0002042)1.99999374
191actin-mediated cell contraction (GO:0070252)1.99903560
192regulation of transforming growth factor beta2 production (GO:0032909)1.99084323
193regulation of gene silencing by RNA (GO:0060966)1.98131127
194regulation of posttranscriptional gene silencing (GO:0060147)1.98131127
195regulation of gene silencing by miRNA (GO:0060964)1.98131127
196multicellular organismal metabolic process (GO:0044236)1.96894991

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.38152225
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.57611262
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.20475040
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.09193016
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.08440975
6* LXR_22158963_ChIP-Seq_LIVER_Mouse3.90233658
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.26248431
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.97824111
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.90103065
10* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.80160908
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.74827052
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.50448312
13* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.43013243
14CLOCK_20551151_ChIP-Seq_293T_Human2.30368977
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.24912989
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.24912989
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.24912989
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04953809
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.01734146
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.94518063
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.91391808
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88207326
23EZH2_22144423_ChIP-Seq_EOC_Human1.88122236
24ZNF263_19887448_ChIP-Seq_K562_Human1.85317340
25* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.82451778
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.75157996
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.69753615
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67310837
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.64154754
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59903366
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59903366
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59738448
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.59534319
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59499114
35* FOXA2_19822575_ChIP-Seq_HepG2_Human1.54697091
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.53885277
37GBX2_23144817_ChIP-Seq_PC3_Human1.50685218
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.47990010
39RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45625733
40SOX9_24532713_ChIP-Seq_HFSC_Mouse1.42268600
41TBX20_22080862_ChIP-Seq_HEART_Mouse1.41614994
42TBX20_22328084_ChIP-Seq_HEART_Mouse1.41614994
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.39447148
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37237653
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.37101003
46RACK7_27058665_Chip-Seq_MCF-7_Human1.36211562
47* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35766657
48* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35007804
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34506186
50LXR_22292898_ChIP-Seq_THP-1_Human1.30755462
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30179672
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.27129125
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26218184
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25720656
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25460486
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23362493
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.23362341
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22978128
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20231768
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19822231
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.19635708
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16893102
63TBX3_20139965_ChIP-Seq_ESCs_Mouse1.16862667
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.16486240
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16043752
66TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15719702
67TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.15613435
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14453722
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.14124564
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12696967
71* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12681987
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.12228290
73SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.11449152
74CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11049030
75TP53_16413492_ChIP-PET_HCT116_Human1.10389136
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08608665
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08310701
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07510414
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07328405
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06662555
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06517274
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05636288
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05242332
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04960600
85SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04816057
86SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04563567
87NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04375749
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04349044
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.03677561
90DROSHA_22980978_ChIP-Seq_HELA_Human1.03198482
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02926202
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02441246
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02379958
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.01861751
95SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01673362
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01571957
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01387159
98RING1B_27294783_Chip-Seq_NPCs_Mouse1.01316903
99OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00925784
100CDX2_20551321_ChIP-Seq_CACO-2_Human1.00826261
101AR_21572438_ChIP-Seq_LNCaP_Human1.00721074
102* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99960893
103KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99511317
104* CTCF_27219007_Chip-Seq_Bcells_Human0.99456311
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98293303
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98052200
107MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97477821
108* TP53_23651856_ChIP-Seq_MEFs_Mouse0.97262737
109ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97006603
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96263059
111ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95861298
112ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95761886
113CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95749348
114SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95505597
115NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95460681
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95460681
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95400018
118TP53_20018659_ChIP-ChIP_R1E_Mouse0.94540449
119STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94142115
120* KDM2B_26808549_Chip-Seq_K562_Human0.94057977
121TP53_18474530_ChIP-ChIP_U2OS_Human0.93967327
122P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93954260
123YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93813067
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.93792906
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93770400
126PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92921823
127* HNF4A_19822575_ChIP-Seq_HepG2_Human0.92678450
128AHR_22903824_ChIP-Seq_MCF-7_Human0.92462472
129* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92420880
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92388808
131TET1_21490601_ChIP-Seq_MESCs_Mouse0.91893888
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91722318
133RUNX1_27514584_Chip-Seq_MCF-7_Human0.90774479
134PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90252581
135NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89746332
136SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89491260
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.88689474
138DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88561761
139CJUN_26792858_Chip-Seq_BT549_Human0.88006803
140GATA4_25053715_ChIP-Seq_YYC3_Human0.87766119
141UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86657116
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85707869
143POU5F1_16518401_ChIP-PET_MESCs_Mouse0.84957104
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84902631
145ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83502310
146* KDM2B_26808549_Chip-Seq_DND41_Human0.81038076
147CREB1_26743006_Chip-Seq_LNCaP_Human0.80849423
148SOX2_20726797_ChIP-Seq_SW620_Human0.80722986
149ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80333903
150TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80048157
151TCF3_18692474_ChIP-Seq_MESCs_Mouse0.78603758
152ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78379671
153CDX2_19796622_ChIP-Seq_MESCs_Mouse0.77648626
154FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.77222815
155* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.76915374

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.97012847
2MP0003705_abnormal_hypodermis_morpholog3.90707821
3MP0005360_urolithiasis3.87731125
4MP0002139_abnormal_hepatobiliary_system3.75626895
5MP0005085_abnormal_gallbladder_physiolo3.58872802
6MP0005365_abnormal_bile_salt3.56381955
7MP0003252_abnormal_bile_duct3.22606564
8MP0005275_abnormal_skin_tensile2.77325671
9MP0008875_abnormal_xenobiotic_pharmacok2.30457633
10MP0003806_abnormal_nucleotide_metabolis2.18843672
11MP0009384_cardiac_valve_regurgitation2.13742722
12MP0003191_abnormal_cellular_cholesterol2.11001404
13MP0004272_abnormal_basement_membrane2.09545998
14MP0000566_synostosis1.90482146
15MP0010329_abnormal_lipoprotein_level1.87563663
16MP0002837_dystrophic_cardiac_calcinosis1.83268798
17MP0005083_abnormal_biliary_tract1.77170559
18MP0009840_abnormal_foam_cell1.73922378
19MP0005503_abnormal_tendon_morphology1.73080879
20MP0005666_abnormal_adipose_tissue1.71683191
21MP0002254_reproductive_system_inflammat1.70008311
22MP0003566_abnormal_cell_adhesion1.66916371
23MP0002060_abnormal_skin_morphology1.65362333
24MP0009780_abnormal_chondrocyte_physiolo1.62759746
25MP0005670_abnormal_white_adipose1.61319561
26MP0005257_abnormal_intraocular_pressure1.53808179
27MP0003283_abnormal_digestive_organ1.53791738
28MP0001666_abnormal_nutrient_absorption1.48719550
29MP0002796_impaired_skin_barrier1.44273260
30MP0005023_abnormal_wound_healing1.43485798
31MP0000751_myopathy1.41450183
32MP0003937_abnormal_limbs/digits/tail_de1.41098442
33MP0009053_abnormal_anal_canal1.40554034
34MP0005623_abnormal_meninges_morphology1.38688398
35MP0005332_abnormal_amino_acid1.37968636
36MP0003279_aneurysm1.36861017
37MP0005330_cardiomyopathy1.36282831
38MP0004084_abnormal_cardiac_muscle1.34567809
39MP0002269_muscular_atrophy1.34149876
40MP0004185_abnormal_adipocyte_glucose1.32802228
41MP0000579_abnormal_nail_morphology1.30422093
42MP0002118_abnormal_lipid_homeostasis1.29836194
43MP0000049_abnormal_middle_ear1.28888124
44MP0008775_abnormal_heart_ventricle1.27832843
45MP0000749_muscle_degeneration1.24528200
46MP0003122_maternal_imprinting1.23938523
47MP0004087_abnormal_muscle_fiber1.22764764
48MP0005451_abnormal_body_composition1.21404983
49MP0000013_abnormal_adipose_tissue1.21357449
50MP0010368_abnormal_lymphatic_system1.20439685
51MP0005375_adipose_tissue_phenotype1.19256546
52MP0002697_abnormal_eye_size1.17625832
53MP0003453_abnormal_keratinocyte_physiol1.17523998
54MP0000609_abnormal_liver_physiology1.16423042
55MP0001661_extended_life_span1.14892037
56MP0003045_fibrosis1.14216990
57MP0004130_abnormal_muscle_cell1.13209254
58MP0002282_abnormal_trachea_morphology1.13128901
59MP0002295_abnormal_pulmonary_circulatio1.12150338
60MP0000467_abnormal_esophagus_morphology1.11359126
61MP0009250_abnormal_appendicular_skeleto1.10541595
62MP0002233_abnormal_nose_morphology1.10350709
63MP0000747_muscle_weakness1.09938961
64MP0004858_abnormal_nervous_system1.08602460
65MP0004264_abnormal_extraembryonic_tissu1.07099216
66MP0005319_abnormal_enzyme/_coenzyme1.06851447
67MP0005508_abnormal_skeleton_morphology1.06442543
68MP0006054_spinal_hemorrhage1.04522495
69MP0000762_abnormal_tongue_morphology1.04217781
70MP0010630_abnormal_cardiac_muscle1.03194749
71MP0000733_abnormal_muscle_development1.02754471
72MP0001849_ear_inflammation1.01932944
73MP0003195_calcinosis1.01286949
74MP0000750_abnormal_muscle_regeneration1.01277349
75MP0000778_abnormal_nervous_system1.00087480
76MP0000534_abnormal_ureter_morphology0.99995997
77MP0004019_abnormal_vitamin_homeostasis0.99685401
78MP0002108_abnormal_muscle_morphology0.99138909
79MP0003136_yellow_coat_color0.99059181
80MP0003119_abnormal_digestive_system0.98927911
81MP0001243_abnormal_dermal_layer0.98441989
82MP0000003_abnormal_adipose_tissue0.98125685
83MP0001958_emphysema0.97964839
84MP0003755_abnormal_palate_morphology0.97869836
85MP0000537_abnormal_urethra_morphology0.96834375
86MP0003868_abnormal_feces_composition0.96620752
87MP0003221_abnormal_cardiomyocyte_apopto0.95562150
88MP0005369_muscle_phenotype0.95425252
89MP0003935_abnormal_craniofacial_develop0.94141198
90MP0000767_abnormal_smooth_muscle0.94010208
91MP0004233_abnormal_muscle_weight0.93708453
92MP0002116_abnormal_craniofacial_bone0.93335280
93MP0003385_abnormal_body_wall0.92799451
94MP0004133_heterotaxia0.92475131
95MP0003950_abnormal_plasma_membrane0.92135084
96MP0005220_abnormal_exocrine_pancreas0.91696767
97MP0002168_other_aberrant_phenotype0.91684367
98MP0001984_abnormal_olfaction0.91642009
99MP0000432_abnormal_head_morphology0.90423357
100MP0010234_abnormal_vibrissa_follicle0.89111273
101MP0005171_absent_coat_pigmentation0.89030703
102MP0005409_darkened_coat_color0.88946379
103MP0001293_anophthalmia0.88588717
104MP0005620_abnormal_muscle_contractility0.86433067
105MP0004145_abnormal_muscle_electrophysio0.86040275
106MP0010678_abnormal_skin_adnexa0.83685015
107MP0002938_white_spotting0.83555230
108MP0000647_abnormal_sebaceous_gland0.82909989
109MP0002092_abnormal_eye_morphology0.82707393
110MP0001177_atelectasis0.81114788
111MP0002111_abnormal_tail_morphology0.80087376
112MP0005248_abnormal_Harderian_gland0.79750769
113MP0002971_abnormal_brown_adipose0.79574515
114MP0002106_abnormal_muscle_physiology0.79479896
115MP0003941_abnormal_skin_development0.78779282
116MP0003115_abnormal_respiratory_system0.78667682
117MP0003091_abnormal_cell_migration0.78665396
118MP0003011_delayed_dark_adaptation0.75881508
119MP0002128_abnormal_blood_circulation0.75313353
120MP0002089_abnormal_postnatal_growth/wei0.75230018
121MP0004036_abnormal_muscle_relaxation0.75206563
122MP0002972_abnormal_cardiac_muscle0.74754008
123MP0003861_abnormal_nervous_system0.74372068
124MP0002114_abnormal_axial_skeleton0.74107501
125MP0002932_abnormal_joint_morphology0.74049756
126MP0001299_abnormal_eye_distance/0.73024696
127MP0006138_congestive_heart_failure0.72755198
128MP0000428_abnormal_craniofacial_morphol0.71455617
129MP0000383_abnormal_hair_follicle0.70372631
130MP0001544_abnormal_cardiovascular_syste0.70313801
131MP0005385_cardiovascular_system_phenoty0.70313801
132MP0009703_decreased_birth_body0.70198764
133MP0003567_abnormal_fetal_cardiomyocyte0.70150849
134MP0000462_abnormal_digestive_system0.70016632
135MP0010030_abnormal_orbit_morphology0.69754784
136MP0009672_abnormal_birth_weight0.69745039
137MP0002084_abnormal_developmental_patter0.69476863
138MP0005501_abnormal_skin_physiology0.69196970
139MP0003890_abnormal_embryonic-extraembry0.68963526
140MP0000759_abnormal_skeletal_muscle0.68707215
141MP0000163_abnormal_cartilage_morphology0.68306990
142MP0004215_abnormal_myocardial_fiber0.68151221
143MP0002896_abnormal_bone_mineralization0.68101037
144MP0002249_abnormal_larynx_morphology0.67806030
145MP0000598_abnormal_liver_morphology0.66434288
146MP0003942_abnormal_urinary_system0.66239279

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.01632689
2Premature rupture of membranes (HP:0001788)4.50431289
3Protrusio acetabuli (HP:0003179)4.21939794
4Complement deficiency (HP:0004431)4.14200191
5Intrahepatic cholestasis (HP:0001406)3.99090750
6Xanthomatosis (HP:0000991)3.94779667
7Increased connective tissue (HP:0009025)3.89292803
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.54661612
9Right ventricular cardiomyopathy (HP:0011663)3.40814194
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.38046515
11Cerebral aneurysm (HP:0004944)3.27598859
12Shallow orbits (HP:0000586)3.24389868
13Prolonged partial thromboplastin time (HP:0003645)3.22535129
14Atrophic scars (HP:0001075)3.14573825
15Abnormality of complement system (HP:0005339)3.08197473
16Neonatal short-limb short stature (HP:0008921)3.06364280
17Hypoalphalipoproteinemia (HP:0003233)3.05512287
18Hyporeflexia of lower limbs (HP:0002600)3.03548156
19Hyperlipoproteinemia (HP:0010980)2.99901375
20Broad metatarsal (HP:0001783)2.88428055
21Abnormality of the common coagulation pathway (HP:0010990)2.83435972
22Mitral valve prolapse (HP:0001634)2.80728982
23Abnormality of the intrinsic pathway (HP:0010989)2.75005235
24Aortic dissection (HP:0002647)2.68731253
25Hypolipoproteinemia (HP:0010981)2.63485605
26Ketosis (HP:0001946)2.61589794
27Hyperammonemia (HP:0001987)2.60970486
28Cervical subluxation (HP:0003308)2.56788632
29Peritonitis (HP:0002586)2.55855619
30Hypobetalipoproteinemia (HP:0003563)2.55250083
31Abnormality of the Achilles tendon (HP:0005109)2.54028255
32Muscle fiber splitting (HP:0003555)2.49893530
33Epidermoid cyst (HP:0200040)2.49683272
34Disproportionate tall stature (HP:0001519)2.49617705
35Abnormality of glycine metabolism (HP:0010895)2.46760307
36Abnormality of serine family amino acid metabolism (HP:0010894)2.46760307
37Ankle contracture (HP:0006466)2.45384923
38Skin nodule (HP:0200036)2.41458853
39Abnormality of dentin (HP:0010299)2.40213957
40Hyperglycinuria (HP:0003108)2.37344907
41Bronchomalacia (HP:0002780)2.36706062
42Hypoglycemic coma (HP:0001325)2.36459048
43Hyperglycinemia (HP:0002154)2.36292555
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.33486127
45Exercise-induced muscle cramps (HP:0003710)2.30676892
46Sudden death (HP:0001699)2.29996996
47Systemic lupus erythematosus (HP:0002725)2.29630987
48Difficulty running (HP:0009046)2.29449216
49Limited hip movement (HP:0008800)2.25695897
50Hemorrhage of the eye (HP:0011885)2.25672316
51Ventricular tachycardia (HP:0004756)2.24981940
52Cardiovascular calcification (HP:0011915)2.24944594
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.24088453
54Joint hemorrhage (HP:0005261)2.23856922
55Myocardial infarction (HP:0001658)2.23839725
56Achilles tendon contracture (HP:0001771)2.23572337
57Bladder diverticulum (HP:0000015)2.23255548
58Blue sclerae (HP:0000592)2.23013538
59Aplasia involving bones of the upper limbs (HP:0009823)2.20644434
60Aplasia of the phalanges of the hand (HP:0009802)2.20644434
61Aplasia involving bones of the extremities (HP:0009825)2.20644434
62Aneurysm (HP:0002617)2.19580123
63Turricephaly (HP:0000262)2.19271042
64Hypoplastic ischia (HP:0003175)2.19194027
65Aortic aneurysm (HP:0004942)2.17935720
66Myoglobinuria (HP:0002913)2.17434102
67Vascular tortuosity (HP:0004948)2.13841342
68Glomerulonephritis (HP:0000099)2.13333503
69Retinal atrophy (HP:0001105)2.12628572
70Type 1 muscle fiber predominance (HP:0003803)2.12326167
71Camptodactyly of toe (HP:0001836)2.12075667
72Ulnar bowing (HP:0003031)2.12072514
73Esophageal varix (HP:0002040)2.11976488
74Abnormality of the ischium (HP:0003174)2.10913172
75Infantile muscular hypotonia (HP:0008947)2.10437649
76Round ear (HP:0100830)2.09021810
77Wide anterior fontanel (HP:0000260)2.08415998
78Soft skin (HP:0000977)2.07893529
79Fragile skin (HP:0001030)2.07186231
80Thin ribs (HP:0000883)2.06998026
81Biconcave vertebral bodies (HP:0004586)2.06654489
82Delayed CNS myelination (HP:0002188)2.06485856
83Scapular winging (HP:0003691)2.06367931
84Bowel diverticulosis (HP:0005222)2.04467287
85Wormian bones (HP:0002645)2.01998345
86Ketoacidosis (HP:0001993)2.01260939
87Coronal craniosynostosis (HP:0004440)1.99263400
88Breech presentation (HP:0001623)1.99096662
89Vascular calcification (HP:0004934)1.97838507
90Abnormal cartilage morphology (HP:0002763)1.97425333
91Abnormality of sulfur amino acid metabolism (HP:0004339)1.96972575
92Lymphangioma (HP:0100764)1.95486223
93Follicular hyperkeratosis (HP:0007502)1.95299010
94Spinal rigidity (HP:0003306)1.93052285
95Distal lower limb muscle weakness (HP:0009053)1.92561125
96Vitreoretinal degeneration (HP:0000655)1.92309454
97Mitral stenosis (HP:0001718)1.90744113
98Renovascular hypertension (HP:0100817)1.90396394
99Exercise-induced myalgia (HP:0003738)1.90348350
100Alopecia of scalp (HP:0002293)1.89110548
101Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.88799089
102Pseudobulbar signs (HP:0002200)1.88503009
103Abnormality of the calcaneus (HP:0008364)1.87396317
104Pterygium (HP:0001059)1.86997767
105Hip contracture (HP:0003273)1.85593562
106Arnold-Chiari malformation (HP:0002308)1.85584508
107Neoplasm of the heart (HP:0100544)1.85163587
108Difficulty climbing stairs (HP:0003551)1.85024535
109Hyperextensible skin (HP:0000974)1.84700950
110Abnormality of fatty-acid metabolism (HP:0004359)1.83939136
111Alacrima (HP:0000522)1.83590306
112Arterial tortuosity (HP:0005116)1.83438822
113Cutaneous finger syndactyly (HP:0010554)1.82905474
114Abnormal delivery (HP:0001787)1.82187832
115Hypoplasia of the iris (HP:0007676)1.80787953
116Mildly elevated creatine phosphokinase (HP:0008180)1.80450274
117Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80247251
118Abnormality of methionine metabolism (HP:0010901)1.79537028
119Calcaneovalgus deformity (HP:0001848)1.78934797
120Increased variability in muscle fiber diameter (HP:0003557)1.78302124
121Natal tooth (HP:0000695)1.77793711
122Cutaneous syndactyly (HP:0012725)1.77460387
123Joint laxity (HP:0001388)1.76275164
124Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76125075
125Broad long bones (HP:0005622)1.75654183
126Advanced eruption of teeth (HP:0006288)1.74929841
127Overgrowth (HP:0001548)1.74708958
128Fat malabsorption (HP:0002630)1.74050656
129Flat cornea (HP:0007720)1.73572703
130EMG: myopathic abnormalities (HP:0003458)1.72796169
131Mitral regurgitation (HP:0001653)1.72106350
132Focal segmental glomerulosclerosis (HP:0000097)1.70948377
133Deformed tarsal bones (HP:0008119)1.69139538
134Amyloidosis (HP:0011034)1.68768611
135Abnormality of the calf musculature (HP:0001430)1.68577875
136Ectopia lentis (HP:0001083)1.68490771
137Back pain (HP:0003418)1.68389205
138Abnormality of the aortic arch (HP:0012303)1.67485004
139Calf muscle hypertrophy (HP:0008981)1.67290033
140Preaxial foot polydactyly (HP:0001841)1.62616905
141Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.61439386
142Genu recurvatum (HP:0002816)1.60051791
143Broad phalanx (HP:0006009)1.59552410
144Short 4th metacarpal (HP:0010044)1.59538440
145Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.59538440
146Popliteal pterygium (HP:0009756)1.59074343
147Dilatation of the ascending aorta (HP:0005111)1.56270786
148Tracheal stenosis (HP:0002777)1.55334960
149Osteoarthritis (HP:0002758)1.54450179
150Choanal stenosis (HP:0000452)1.53724070
151Distal arthrogryposis (HP:0005684)1.53529591
152Wrist flexion contracture (HP:0001239)1.53517588
153Hyperacusis (HP:0010780)1.52819577
154Renal duplication (HP:0000075)1.52457154
155Rhizomelia (HP:0008905)1.51728492
156Decreased lacrimation (HP:0000633)1.48182500
157Bell-shaped thorax (HP:0001591)1.48086156
158Partial duplication of the phalanx of hand (HP:0009999)1.47528710
159Vertebral arch anomaly (HP:0008438)1.46849788
160Broad finger (HP:0001500)1.46495907
161Broad phalanges of the hand (HP:0009768)1.46228546
162Hammertoe (HP:0001765)1.44878440
163Tracheomalacia (HP:0002779)1.44248702
164Morphological abnormality of the middle ear (HP:0008609)1.44111409
165Partial duplication of thumb phalanx (HP:0009944)1.43677020

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.29304286
2SIK12.90735443
3ERN12.89378031
4DDR22.81889290
5TGFBR22.65445727
6PKN22.50185858
7LATS12.40340923
8MAP3K62.35479691
9BCKDK2.24558611
10TTN2.23576030
11EPHB12.10870114
12EEF2K2.07609410
13FGFR41.99551463
14PDGFRA1.95920326
15MAPK151.84547420
16ICK1.78941153
17MARK11.77964293
18TYRO31.76264676
19MET1.74610067
20MAP2K31.73530534
21OBSCN1.72255392
22MAPKAPK31.71155475
23PBK1.60693572
24EPHA21.57782715
25MAP3K31.56146396
26LATS21.52476542
27FER1.41589160
28PTK61.40559528
29PAK41.40543693
30PTK21.39898870
31TNIK1.34706485
32CDK121.32858314
33MTOR1.24437460
34RIPK11.22141100
35LMTK21.20360212
36PAK31.15793567
37PRKD31.15053615
38DMPK1.12214516
39PDK21.11928077
40PAK21.09996574
41PHKG21.08551299
42PHKG11.08551299
43EPHA31.08028479
44TTK1.04685577
45EPHB21.04657738
46NTRK31.03136412
47MAP2K41.02092213
48MUSK0.99916427
49DYRK1B0.99371159
50BCR0.97225599
51MAP3K70.95553609
52MAP3K100.93611752
53RPS6KB20.92829087
54ERBB20.92577733
55TRPM70.90999717
56RET0.90952639
57PDGFRB0.89862583
58FGFR20.87669113
59CASK0.86362753
60CAMK1D0.84604587
61DYRK20.84556491
62CSK0.83867492
63MAP3K20.83521113
64STK390.82930341
65PKN10.81707565
66PRKAA20.80764856
67PINK10.80643359
68PDK40.78068549
69PDK30.78068549
70PRKD10.77394502
71AKT30.76883278
72NEK20.76818806
73RPS6KA20.76480798
74STK380.76365242
75BMX0.75894322
76MAPK120.75557443
77MAPK70.75218141
78IRAK10.74832042
79STK38L0.73920514
80NEK10.73061101
81NEK90.71704917
82ERBB40.71000881
83CAMK1G0.70580248
84MAP2K10.70153627
85NTRK10.70049923
86WNK10.70022161
87GSK3A0.68644200
88EPHA40.68533479
89FLT30.67178979
90NLK0.66984236
91PIK3CA0.66581034
92PNCK0.65938354
93INSRR0.64552977
94NTRK20.64481815
95CDK30.61039538
96MST1R0.60418418
97PRKD20.60399695
98ROCK10.59818089
99LIMK10.59178080
100PIK3CG0.59140657
101PAK60.59048956
102MAP2K20.58924589
103STK30.58574654
104SGK2230.58186247
105SGK4940.58186247
106AKT20.57617143
107MAPK110.56656786
108BRSK20.56569011
109ILK0.55198163
110ROCK20.53857766
111MAPKAPK50.50295615
112CAMK2G0.49639585
113MAP3K40.47488493
114MYLK0.46748750
115TIE10.45164564
116IGF1R0.44535032
117JAK10.44299395
118WNK40.44239070
119CAMK2D0.44231912
120CDC42BPA0.44039139
121MARK20.43356025
122CSF1R0.43325167
123FGFR10.41536721
124MAP2K60.41328290
125KSR20.40778450
126BMPR1B0.40150761
127JAK20.39796640
128PRKAA10.39620867
129CAMK40.39511692
130NME10.37730634
131LRRK20.37638601
132BRSK10.37280806
133TESK10.37250100
134CSNK1G10.34985907
135MAPK100.34412722

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.33897081
2Nitrogen metabolism_Homo sapiens_hsa009103.22170101
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.86581501
4Fatty acid degradation_Homo sapiens_hsa000712.61299580
5Arginine biosynthesis_Homo sapiens_hsa002202.53128530
6Complement and coagulation cascades_Homo sapiens_hsa046102.46395191
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45487937
8Tryptophan metabolism_Homo sapiens_hsa003802.28841831
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.28438837
10Fatty acid metabolism_Homo sapiens_hsa012122.27905859
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23196531
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.20035661
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.18099707
14Propanoate metabolism_Homo sapiens_hsa006402.12788153
15PPAR signaling pathway_Homo sapiens_hsa033201.99155004
16Butanoate metabolism_Homo sapiens_hsa006501.92261663
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83078435
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.70310522
19Fatty acid elongation_Homo sapiens_hsa000621.67092212
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.61417693
21Chemical carcinogenesis_Homo sapiens_hsa052041.57222383
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56462950
23Selenocompound metabolism_Homo sapiens_hsa004501.55895300
24Lysine degradation_Homo sapiens_hsa003101.53304524
25Peroxisome_Homo sapiens_hsa041461.49883339
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.49591916
27Staphylococcus aureus infection_Homo sapiens_hsa051501.45264857
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42414617
29beta-Alanine metabolism_Homo sapiens_hsa004101.37294483
30Phenylalanine metabolism_Homo sapiens_hsa003601.34271654
31Bile secretion_Homo sapiens_hsa049761.32581169
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27359048
33Steroid biosynthesis_Homo sapiens_hsa001001.25635896
34ECM-receptor interaction_Homo sapiens_hsa045121.25251323
35Fat digestion and absorption_Homo sapiens_hsa049751.23556140
36ABC transporters_Homo sapiens_hsa020101.22409816
37Pyruvate metabolism_Homo sapiens_hsa006201.20211792
38Histidine metabolism_Homo sapiens_hsa003401.18219154
39Carbon metabolism_Homo sapiens_hsa012001.16433723
40Tyrosine metabolism_Homo sapiens_hsa003501.15252503
41Biosynthesis of amino acids_Homo sapiens_hsa012301.11591852
42Retinol metabolism_Homo sapiens_hsa008301.06142492
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.04246116
44Starch and sucrose metabolism_Homo sapiens_hsa005001.03630289
45Circadian rhythm_Homo sapiens_hsa047101.01977465
46Fatty acid biosynthesis_Homo sapiens_hsa000611.00129336
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99400186
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.98795599
49Wnt signaling pathway_Homo sapiens_hsa043100.95949894
50Arginine and proline metabolism_Homo sapiens_hsa003300.95314019
51Melanogenesis_Homo sapiens_hsa049160.93425086
52Basal cell carcinoma_Homo sapiens_hsa052170.89097663
53Prion diseases_Homo sapiens_hsa050200.87834283
54Caffeine metabolism_Homo sapiens_hsa002320.86744479
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83671228
56Protein digestion and absorption_Homo sapiens_hsa049740.83530645
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82663093
58Insulin resistance_Homo sapiens_hsa049310.79542881
59Focal adhesion_Homo sapiens_hsa045100.78650026
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77879451
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77855113
62Sulfur metabolism_Homo sapiens_hsa009200.77733526
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76719088
64Ovarian steroidogenesis_Homo sapiens_hsa049130.76687808
65MicroRNAs in cancer_Homo sapiens_hsa052060.75179414
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.74726181
67Vitamin B6 metabolism_Homo sapiens_hsa007500.74118117
68Hippo signaling pathway_Homo sapiens_hsa043900.72087541
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.71709273
70Adherens junction_Homo sapiens_hsa045200.71308631
71Thyroid hormone synthesis_Homo sapiens_hsa049180.71302654
72Glycerolipid metabolism_Homo sapiens_hsa005610.70645515
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69691351
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69174526
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68986648
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68209719
77Folate biosynthesis_Homo sapiens_hsa007900.67221397
78Glutathione metabolism_Homo sapiens_hsa004800.67021051
79Vitamin digestion and absorption_Homo sapiens_hsa049770.65971700
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.65136715
81Insulin signaling pathway_Homo sapiens_hsa049100.64987372
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64909224
83Gap junction_Homo sapiens_hsa045400.64824038
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.64132983
85Dilated cardiomyopathy_Homo sapiens_hsa054140.63602392
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.63135442
87Melanoma_Homo sapiens_hsa052180.61721615
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59383550
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59320889
90Amoebiasis_Homo sapiens_hsa051460.56868969
91TGF-beta signaling pathway_Homo sapiens_hsa043500.56086460
92Choline metabolism in cancer_Homo sapiens_hsa052310.55871213
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55725752
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54997050
95Proteoglycans in cancer_Homo sapiens_hsa052050.54682814
96Pathways in cancer_Homo sapiens_hsa052000.54218009
97Other glycan degradation_Homo sapiens_hsa005110.54199197
98Small cell lung cancer_Homo sapiens_hsa052220.53847932
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.53221463
100Hedgehog signaling pathway_Homo sapiens_hsa043400.51791815
101Tight junction_Homo sapiens_hsa045300.51324516
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49906455
103Endometrial cancer_Homo sapiens_hsa052130.48463239
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.48256503
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46644300
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45669111
107Bladder cancer_Homo sapiens_hsa052190.45299798
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44962606
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42531884
110Rap1 signaling pathway_Homo sapiens_hsa040150.42184577
111Gastric acid secretion_Homo sapiens_hsa049710.41377840
112Arachidonic acid metabolism_Homo sapiens_hsa005900.40409503
113Notch signaling pathway_Homo sapiens_hsa043300.39814259
114Sulfur relay system_Homo sapiens_hsa041220.39296458
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.39062111
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38842878
117AMPK signaling pathway_Homo sapiens_hsa041520.38033176
118Ether lipid metabolism_Homo sapiens_hsa005650.35247154
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.34175428
120Glucagon signaling pathway_Homo sapiens_hsa049220.29299845
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26064088
122Fructose and mannose metabolism_Homo sapiens_hsa000510.25852022
123Axon guidance_Homo sapiens_hsa043600.25587267
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24505816
125Metabolic pathways_Homo sapiens_hsa011000.24432976
126Linoleic acid metabolism_Homo sapiens_hsa005910.22066051
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21231292
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21160185

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