ASB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains an ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, targeting them for ubiquitination and degradation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.98291370
2acrosome reaction (GO:0007340)5.77209928
3motile cilium assembly (GO:0044458)5.71403141
4cilium or flagellum-dependent cell motility (GO:0001539)5.59958186
5axonemal dynein complex assembly (GO:0070286)5.12664726
6cell wall macromolecule metabolic process (GO:0044036)5.03472311
7cell wall macromolecule catabolic process (GO:0016998)5.03472311
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.99956291
9fusion of sperm to egg plasma membrane (GO:0007342)4.98795348
10microtubule depolymerization (GO:0007019)4.93000486
11negative regulation of translation, ncRNA-mediated (GO:0040033)4.68651430
12regulation of translation, ncRNA-mediated (GO:0045974)4.68651430
13negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.68651430
14calcium ion-dependent exocytosis (GO:0017156)4.50230896
15acrosome assembly (GO:0001675)4.48405924
16plasma membrane fusion (GO:0045026)4.11678044
17cell-substrate adherens junction assembly (GO:0007045)4.05405981
18focal adhesion assembly (GO:0048041)4.05405981
19multicellular organism reproduction (GO:0032504)4.03026045
20barbed-end actin filament capping (GO:0051016)4.02424604
21protein localization to endosome (GO:0036010)4.02213293
22regulation of synaptic vesicle exocytosis (GO:2000300)3.96449915
23sperm motility (GO:0030317)3.92448171
24vocalization behavior (GO:0071625)3.92134886
25skin morphogenesis (GO:0043589)3.91074332
26synaptic vesicle maturation (GO:0016188)3.87628377
27negative regulation of synaptic transmission, GABAergic (GO:0032229)3.87449969
28positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.87261069
29cell-substrate junction assembly (GO:0007044)3.85329019
30adherens junction assembly (GO:0034333)3.84948766
31pre-miRNA processing (GO:0031054)3.76903579
32epithelial cilium movement (GO:0003351)3.75144729
33regulation of action potential (GO:0098900)3.70985679
34synaptic vesicle exocytosis (GO:0016079)3.67426601
35neuron cell-cell adhesion (GO:0007158)3.63025687
36positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.56998363
37protein localization to synapse (GO:0035418)3.54174116
38cytoskeletal anchoring at plasma membrane (GO:0007016)3.50789297
39COPI coating of Golgi vesicle (GO:0048205)3.46155951
40Golgi transport vesicle coating (GO:0048200)3.46155951
41epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.44496061
42locomotory exploration behavior (GO:0035641)3.43665004
43regulation of histone H3-K27 methylation (GO:0061085)3.41202368
44regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.41157359
45male meiosis (GO:0007140)3.39776386
46stress fiber assembly (GO:0043149)3.39530738
47negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.37532123
48reproduction (GO:0000003)3.37112508
49DNA methylation involved in gamete generation (GO:0043046)3.36903135
50hypotonic response (GO:0006971)3.35894220
51sperm-egg recognition (GO:0035036)3.35456544
52positive regulation of synaptic transmission, GABAergic (GO:0032230)3.34739161
53regulation of synaptic vesicle transport (GO:1902803)3.34347435
54planar cell polarity pathway involved in neural tube closure (GO:0090179)3.32535343
55microtubule polymerization or depolymerization (GO:0031109)3.31753926
56negative regulation of potassium ion transmembrane transport (GO:1901380)3.30236251
57spermatid development (GO:0007286)3.28488516
58glutamate secretion (GO:0014047)3.28254079
59positive regulation of myotube differentiation (GO:0010831)3.27725937
60regulation of mammary gland epithelial cell proliferation (GO:0033599)3.27511955
61cilium movement (GO:0003341)3.19262067
62regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.17170727
63layer formation in cerebral cortex (GO:0021819)3.16294667
64regulation of neuronal synaptic plasticity (GO:0048168)3.15948806
65regulation of glutamate receptor signaling pathway (GO:1900449)3.14135432
66muscle filament sliding (GO:0030049)3.14099804
67actin-myosin filament sliding (GO:0033275)3.14099804
68synaptic vesicle endocytosis (GO:0048488)3.12560045
69negative regulation of inclusion body assembly (GO:0090084)3.11999857
70regulation of extracellular matrix disassembly (GO:0010715)3.11382330
71hemidesmosome assembly (GO:0031581)3.10316735
72positive regulation of blood vessel endothelial cell migration (GO:0043536)3.09789688
73regulation of early endosome to late endosome transport (GO:2000641)3.08500654
74endodermal cell differentiation (GO:0035987)3.07115284
75proline transport (GO:0015824)3.06867166
76maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.04884927
77negative regulation of organelle assembly (GO:1902116)3.04754520
78negative regulation of neurotransmitter transport (GO:0051589)3.04387422
79ionotropic glutamate receptor signaling pathway (GO:0035235)3.02510891
80protein retention in ER lumen (GO:0006621)3.02310453
81meiotic cell cycle (GO:0051321)2.99033107
82protein localization to cilium (GO:0061512)2.97074893
83cell-cell recognition (GO:0009988)2.95257688
84regulation of NFAT protein import into nucleus (GO:0051532)2.94119653
85protein targeting to plasma membrane (GO:0072661)2.93454242
86peptidyl-proline hydroxylation (GO:0019511)2.91329265
87positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.90683938
88regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.90683938
89cellular response to prostaglandin stimulus (GO:0071379)2.89908833
90cell adhesion mediated by integrin (GO:0033627)2.89452970
91protein K11-linked deubiquitination (GO:0035871)2.87046506
92neuron recognition (GO:0008038)2.86187503
93neurotransmitter secretion (GO:0007269)2.86161643
94protein hydroxylation (GO:0018126)2.84937125
95membrane depolarization during action potential (GO:0086010)2.84770463
96dendritic spine morphogenesis (GO:0060997)2.84328037
97exploration behavior (GO:0035640)2.83335809
98macroautophagy (GO:0016236)2.83016629
99cerebellum development (GO:0021549)2.82832604
100actin-mediated cell contraction (GO:0070252)2.81678524
101lipid particle organization (GO:0034389)2.80210158
102regulation of synaptic transmission, GABAergic (GO:0032228)2.80197127
103negative regulation of cell size (GO:0045792)2.79238358
104ventricular system development (GO:0021591)2.78831241
105negative regulation of fatty acid transport (GO:2000192)2.78325096
106basement membrane organization (GO:0071711)2.77065618
107cortical actin cytoskeleton organization (GO:0030866)2.76618550
108regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.76409774
109neuronal action potential propagation (GO:0019227)2.74159651
110regulation of glucose import in response to insulin stimulus (GO:2001273)2.73493171
111regulation of neurotransmitter secretion (GO:0046928)2.72150862
112regulation of synapse structural plasticity (GO:0051823)2.69537750
113axonal fasciculation (GO:0007413)2.68642370
114positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.68606568
115cell migration in hindbrain (GO:0021535)2.68194738
116positive regulation of extracellular matrix organization (GO:1903055)2.67075869
117response to methylmercury (GO:0051597)2.66691763
118synaptic transmission, glutamatergic (GO:0035249)2.66623830
119membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.66307137
120regulation of excitatory postsynaptic membrane potential (GO:0060079)2.66191115
121glutamate receptor signaling pathway (GO:0007215)2.65944474
122retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.65860971
123dendrite morphogenesis (GO:0048813)2.65109998
124binding of sperm to zona pellucida (GO:0007339)2.64244887
125neuron-neuron synaptic transmission (GO:0007270)2.63443608
126synaptic vesicle docking involved in exocytosis (GO:0016081)2.63436376
127positive regulation of action potential (GO:0045760)2.63331290
128insulin-like growth factor receptor signaling pathway (GO:0048009)2.62363670
129chondrocyte proliferation (GO:0035988)2.62322388
130regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.61761222
131axon cargo transport (GO:0008088)2.61033046
132nerve growth factor signaling pathway (GO:0038180)2.59829124
133regulation of long-term neuronal synaptic plasticity (GO:0048169)2.59288007
134embryonic process involved in female pregnancy (GO:0060136)2.59009175
135establishment of protein localization to Golgi (GO:0072600)2.58406351
136plasma membrane repair (GO:0001778)2.57531942
137actin filament depolymerization (GO:0030042)2.56757815
138vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.56571384
139activation of Rac GTPase activity (GO:0032863)2.56329395
140startle response (GO:0001964)2.55648920
141positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.55520082
142venous blood vessel morphogenesis (GO:0048845)2.55509494
143negative regulation of anoikis (GO:2000811)2.55380374
144response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.54056218
145protein targeting to Golgi (GO:0000042)2.54027092
146activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.53582328
147apoptotic process involved in morphogenesis (GO:0060561)2.52991894
148lipoprotein transport (GO:0042953)2.52179250
149gamma-aminobutyric acid transport (GO:0015812)2.52145970
150negative regulation of fibrinolysis (GO:0051918)2.51734413
151retrograde transport, vesicle recycling within Golgi (GO:0000301)2.50732234
152actin filament-based movement (GO:0030048)2.50147170
153presynaptic membrane assembly (GO:0097105)2.49653903
154collagen fibril organization (GO:0030199)2.49529971
155regulation of protein kinase A signaling (GO:0010738)2.49427125
156negative regulation of neurotransmitter secretion (GO:0046929)2.48851134
157presynaptic membrane organization (GO:0097090)2.48583428
158regulation of postsynaptic membrane potential (GO:0060078)2.48441470
159sarcoplasmic reticulum calcium ion transport (GO:0070296)2.46269308
160sarcomere organization (GO:0045214)2.45815038
161cardiac myofibril assembly (GO:0055003)2.45336972
162cortical cytoskeleton organization (GO:0030865)2.44957005
163regulation of anoikis (GO:2000209)2.44733322
164regulation of extracellular matrix organization (GO:1903053)2.44150790
165actin filament bundle organization (GO:0061572)2.42950874
166actin filament bundle assembly (GO:0051017)2.42950874
167positive regulation of nuclease activity (GO:0032075)2.41060503
168semaphorin-plexin signaling pathway (GO:0071526)2.40109817
169substrate-dependent cell migration (GO:0006929)2.39361728
170paraxial mesoderm development (GO:0048339)2.38390891
171cell migration involved in sprouting angiogenesis (GO:0002042)2.36703654
172negative regulation of skeletal muscle tissue development (GO:0048642)2.35739085
173blood vessel endothelial cell migration (GO:0043534)2.34276015
174cellular response to epidermal growth factor stimulus (GO:0071364)2.33185902
175negative regulation of chondrocyte differentiation (GO:0032331)2.31724447
176cell migration involved in heart development (GO:0060973)2.31147462
177myoblast fusion (GO:0007520)2.31059326
178negative regulation of catenin import into nucleus (GO:0035414)2.30896381
179negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.29964799
180epithelial cell-cell adhesion (GO:0090136)2.29917813
181regulation of ARF protein signal transduction (GO:0032012)2.24663396
182regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.24152683
183pinocytosis (GO:0006907)2.23990129
184endoplasmic reticulum unfolded protein response (GO:0030968)2.23533462
185syncytium formation by plasma membrane fusion (GO:0000768)2.23414201
186myofibril assembly (GO:0030239)2.23292279
187cellular response to hepatocyte growth factor stimulus (GO:0035729)2.23111569
188response to hepatocyte growth factor (GO:0035728)2.23111569
189regulation of nucleobase-containing compound transport (GO:0032239)2.21749865
190negative regulation of necroptotic process (GO:0060546)2.21559610
191response to muscle activity (GO:0014850)2.21425025
192positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.20476096
193mammary gland epithelial cell proliferation (GO:0033598)2.20437407
194convergent extension (GO:0060026)2.19547235
195negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.19429184
196response to laminar fluid shear stress (GO:0034616)2.17181042
197cardiac muscle contraction (GO:0060048)2.16679745
198peptidyl-threonine modification (GO:0018210)2.16630565
199regulation of response to osmotic stress (GO:0047484)2.16588181

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.18914984
2EZH2_22144423_ChIP-Seq_EOC_Human4.87171068
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.89488685
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.61677244
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.58996998
6GBX2_23144817_ChIP-Seq_PC3_Human3.01680253
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.00983412
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.85406395
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.51087907
10REST_21632747_ChIP-Seq_MESCs_Mouse2.48733438
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.40703355
12MYC_22102868_ChIP-Seq_BL_Human2.25883682
13ZFP281_18757296_ChIP-ChIP_E14_Mouse2.22801547
14* LXR_22292898_ChIP-Seq_THP-1_Human2.21858211
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.21301101
16CLOCK_20551151_ChIP-Seq_293T_Human2.20190765
17RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.19024055
18WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.17212778
19AR_21572438_ChIP-Seq_LNCaP_Human2.16693930
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.15454564
21KDM2B_26808549_Chip-Seq_K562_Human2.09897212
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.07187712
23KDM2B_26808549_Chip-Seq_DND41_Human2.05550143
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98872044
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95605577
26RARB_27405468_Chip-Seq_BRAIN_Mouse1.95034633
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94127231
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93816940
29P300_27058665_Chip-Seq_ZR-75-30cells_Human1.93697522
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93527112
31TCF7_22412390_ChIP-Seq_EML_Mouse1.93526746
32VDR_21846776_ChIP-Seq_THP-1_Human1.93280714
33RACK7_27058665_Chip-Seq_MCF-7_Human1.93064797
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.92706441
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90166987
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82390015
37ZNF263_19887448_ChIP-Seq_K562_Human1.82312542
38* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.81957065
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79993124
40* REST_18959480_ChIP-ChIP_MESCs_Mouse1.78660617
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.73438915
42* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.72263370
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71862716
44SMAD4_21799915_ChIP-Seq_A2780_Human1.71796107
45ELK4_26923725_Chip-Seq_MESODERM_Mouse1.71750941
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71511472
47* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71131882
48DROSHA_22980978_ChIP-Seq_HELA_Human1.68121037
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67917002
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67092658
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66251112
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.63504853
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63174383
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62348457
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.61559796
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59672150
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.58966228
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57757600
59DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55805512
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55560245
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55495654
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55456807
63* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55448601
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.55385235
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55201632
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.53822978
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53540342
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52515445
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52515445
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50689478
71TP53_22127205_ChIP-Seq_IMR90_Human1.48830945
72SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45340968
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.44806126
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.44802511
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43443327
76TBX20_22080862_ChIP-Seq_HEART_Mouse1.42974687
77TBX20_22328084_ChIP-Seq_HEART_Mouse1.42974687
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39823598
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39668959
80* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38676761
81ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.37285845
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36936111
83ERG_21242973_ChIP-ChIP_JURKAT_Human1.36909411
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.35922737
85ATF3_27146783_Chip-Seq_COLON_Human1.34807554
86STAT3_23295773_ChIP-Seq_U87_Human1.34340741
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33928571
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.33500229
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32562827
90* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32244479
91* TCF4_23295773_ChIP-Seq_U87_Human1.32037597
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32023924
93SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31655055
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31375103
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29273542
96NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.29256948
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28531908
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.28464958
99P300_19829295_ChIP-Seq_ESCs_Human1.27879895
100JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26965173
101CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26665455
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25718803
103ER_23166858_ChIP-Seq_MCF-7_Human1.24000331
104ZNF274_21170338_ChIP-Seq_K562_Hela1.23678070
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23143829
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.23004915
107* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22383417
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22046708
109BCAT_22108803_ChIP-Seq_LS180_Human1.21303687
110* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21213712
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20977870
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20701198
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20165586
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19828957
115TP53_23651856_ChIP-Seq_MEFs_Mouse1.19051775
116SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18491555
117* NANOG_18555785_Chip-Seq_ESCs_Mouse1.18062957
118EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17213207
119RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17213207
120* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17105099
121SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17051060
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17046719
123* KDM2B_26808549_Chip-Seq_REH_Human1.16919264
124FLI1_21867929_ChIP-Seq_TH2_Mouse1.16762952
125* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15927735
126BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15611180
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15540575
128TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.15195280
129SMC1_22415368_ChIP-Seq_MEFs_Mouse1.14619043
130* SOX2_21211035_ChIP-Seq_LN229_Gbm1.14180651
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14043679
132KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.13887312
133TET1_21451524_ChIP-Seq_MESCs_Mouse1.13269521
134OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13185954
135PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12841015
136* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12691568
137FOXM1_23109430_ChIP-Seq_U2OS_Human1.11968010
138POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11844790
139IGF1R_20145208_ChIP-Seq_DFB_Human1.11528722
140* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10827295
141CREB1_26743006_Chip-Seq_LNCaP_Human1.10513700
142P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10432809
143TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09876120
144AR_25329375_ChIP-Seq_VCAP_Human1.09629955
145* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09445070
146PRDM14_20953172_ChIP-Seq_ESCs_Human1.08538192
147TAL1_26923725_Chip-Seq_HPCs_Mouse1.08306285
148DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07728630
149* E2F1_18555785_Chip-Seq_ESCs_Mouse1.07292032
150TAF15_26573619_Chip-Seq_HEK293_Human1.07260932
151RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06993568
152PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06913554
153SA1_27219007_Chip-Seq_ERYTHROID_Human1.06614483
154* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06325280
155* CMYC_18555785_Chip-Seq_ESCs_Mouse1.06262067
156TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06203909
157VDR_22108803_ChIP-Seq_LS180_Human1.06181362
158MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05446393
159* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05372967
160SMC4_20622854_ChIP-Seq_HELA_Human1.05341556
161SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05265662
162CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04927376
163CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04031120
164NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03758107
165* RUNX2_22187159_ChIP-Seq_PCA_Human1.02819722
166SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01637549
167* STAT3_18555785_Chip-Seq_ESCs_Mouse1.01459930
168MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01348410
169SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01010450
170SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01010450
171ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00674395
172MAF_26560356_Chip-Seq_TH1_Human1.00201813
173SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99859501
174* P53_22387025_ChIP-Seq_ESCs_Mouse0.99454703
175UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98877655
176* P300_18555785_Chip-Seq_ESCs_Mouse0.98515841
177NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98354229
178RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97729322
179TET1_21490601_ChIP-Seq_MESCs_Mouse0.97635260
180EED_16625203_ChIP-ChIP_MESCs_Mouse0.97151166
181* CRX_20693478_ChIP-Seq_RETINA_Mouse0.97127142
182CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96847453
183VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96556319
184* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96295573
185* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96012456
186HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95997821
187SMAD4_21741376_ChIP-Seq_EPCs_Human0.95982557
188* NFE2_27457419_Chip-Seq_LIVER_Mouse0.95501721
189BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94606007
190* SOX2_18555785_Chip-Seq_ESCs_Mouse0.94188824
191SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93877027
192FUS_26573619_Chip-Seq_HEK293_Human0.93876459
193EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93626983
194EP300_21415370_ChIP-Seq_HL-1_Mouse0.93117755
195MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93107965
196* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92950830
197SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91636619

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.97999982
2MP0008438_abnormal_cutaneous_collagen4.83079648
3MP0004859_abnormal_synaptic_plasticity4.35846742
4MP0005410_abnormal_fertilization4.30126487
5MP0005409_darkened_coat_color3.90973032
6MP0009046_muscle_twitch3.73286874
7MP0000751_myopathy3.31874618
8MP0003880_abnormal_central_pattern3.27550485
9MP0003635_abnormal_synaptic_transmissio3.15879606
10MP0004270_analgesia3.12455302
11MP0003566_abnormal_cell_adhesion2.96736492
12MP0005451_abnormal_body_composition2.74206729
13MP0002064_seizures2.59134191
14MP0001968_abnormal_touch/_nociception2.57344855
15MP0002063_abnormal_learning/memory/cond2.53504727
16MP0000015_abnormal_ear_pigmentation2.49297238
17MP0005257_abnormal_intraocular_pressure2.49059882
18MP0002735_abnormal_chemical_nociception2.46469285
19MP0009745_abnormal_behavioral_response2.45706052
20MP0001958_emphysema2.40039578
21MP0004272_abnormal_basement_membrane2.38184794
22MP0000733_abnormal_muscle_development2.30009429
23MP0002734_abnormal_mechanical_nocicepti2.28207229
24MP0000749_muscle_degeneration2.20148938
25MP0002877_abnormal_melanocyte_morpholog2.17704020
26MP0002572_abnormal_emotion/affect_behav2.16471363
27MP0005423_abnormal_somatic_nervous2.08808256
28MP0001486_abnormal_startle_reflex2.07622794
29MP0003279_aneurysm2.07244426
30MP0003091_abnormal_cell_migration2.06713189
31MP0000759_abnormal_skeletal_muscle2.05230133
32MP0002272_abnormal_nervous_system2.00645740
33MP0003698_abnormal_male_reproductive2.00517546
34MP0002736_abnormal_nociception_after2.00119100
35MP0004087_abnormal_muscle_fiber1.99806701
36MP0009780_abnormal_chondrocyte_physiolo1.99508619
37MP0002733_abnormal_thermal_nociception1.98646219
38MP0004811_abnormal_neuron_physiology1.86516341
39MP0001849_ear_inflammation1.85362142
40MP0001529_abnormal_vocalization1.85236187
41MP0005076_abnormal_cell_differentiation1.85148845
42MP0002822_catalepsy1.78883674
43MP0001188_hyperpigmentation1.73842549
44MP0000955_abnormal_spinal_cord1.73203998
45MP0001970_abnormal_pain_threshold1.70024377
46MP0000778_abnormal_nervous_system1.69884337
47MP0004185_abnormal_adipocyte_glucose1.68969875
48MP0002184_abnormal_innervation1.68579018
49MP0002089_abnormal_postnatal_growth/wei1.67946640
50MP0002067_abnormal_sensory_capabilities1.67120739
51MP0009384_cardiac_valve_regurgitation1.65081187
52MP0001348_abnormal_lacrimal_gland1.64178101
53MP0004130_abnormal_muscle_cell1.63676686
54MP0003950_abnormal_plasma_membrane1.61447447
55MP0000750_abnormal_muscle_regeneration1.61234435
56MP0000747_muscle_weakness1.60818689
57MP0000767_abnormal_smooth_muscle1.60263759
58MP0005275_abnormal_skin_tensile1.54644884
59MP0000003_abnormal_adipose_tissue1.52258416
60* MP0001929_abnormal_gametogenesis1.51480424
61MP0005503_abnormal_tendon_morphology1.51473530
62MP0005023_abnormal_wound_healing1.51058532
63MP0004924_abnormal_behavior1.50867532
64MP0005386_behavior/neurological_phenoty1.50867532
65MP0004147_increased_porphyrin_level1.47160621
66MP0001440_abnormal_grooming_behavior1.46445379
67MP0010368_abnormal_lymphatic_system1.43832285
68MP0005645_abnormal_hypothalamus_physiol1.43773173
69MP0010630_abnormal_cardiac_muscle1.42859312
70MP0002106_abnormal_muscle_physiology1.41896720
71MP0001915_intracranial_hemorrhage1.40299707
72MP0005646_abnormal_pituitary_gland1.37922994
73MP0004043_abnormal_pH_regulation1.37636586
74MP0008877_abnormal_DNA_methylation1.36756959
75MP0004858_abnormal_nervous_system1.35316243
76MP0004036_abnormal_muscle_relaxation1.34594590
77MP0006276_abnormal_autonomic_nervous1.34564153
78MP0005330_cardiomyopathy1.33892894
79MP0002557_abnormal_social/conspecific_i1.32742687
80MP0001501_abnormal_sleep_pattern1.31149646
81MP0001984_abnormal_olfaction1.31003195
82MP0010030_abnormal_orbit_morphology1.30354367
83MP0002653_abnormal_ependyma_morphology1.30353300
84MP0008569_lethality_at_weaning1.30024692
85MP0003300_gastrointestinal_ulcer1.29901583
86MP0005174_abnormal_tail_pigmentation1.29502339
87MP0005369_muscle_phenotype1.29307108
88MP0000920_abnormal_myelination1.29203257
89MP0002837_dystrophic_cardiac_calcinosis1.29070464
90MP0005623_abnormal_meninges_morphology1.28121893
91MP0003329_amyloid_beta_deposits1.25500590
92MP0001299_abnormal_eye_distance/1.24418404
93MP0002882_abnormal_neuron_morphology1.24229073
94MP0004142_abnormal_muscle_tone1.24055189
95MP0002896_abnormal_bone_mineralization1.23984282
96MP0000534_abnormal_ureter_morphology1.23750339
97MP0002066_abnormal_motor_capabilities/c1.21363122
98MP0004084_abnormal_cardiac_muscle1.21219138
99MP0003632_abnormal_nervous_system1.21160529
100MP0003942_abnormal_urinary_system1.20697037
101MP0002060_abnormal_skin_morphology1.20620635
102MP0005535_abnormal_body_temperature1.20181403
103MP0003631_nervous_system_phenotype1.20030814
104MP0008260_abnormal_autophagy1.19940633
105MP0002108_abnormal_muscle_morphology1.19884447
106MP0000678_abnormal_parathyroid_gland1.14327206
107MP0002152_abnormal_brain_morphology1.13342598
108MP0002909_abnormal_adrenal_gland1.12528623
109MP0005375_adipose_tissue_phenotype1.11898821
110MP0004510_myositis1.10140880
111MP0000762_abnormal_tongue_morphology1.10138347
112MP0003941_abnormal_skin_development1.09956960
113MP0003633_abnormal_nervous_system1.09086376
114MP0000858_altered_metastatic_potential1.07583821
115MP0000428_abnormal_craniofacial_morphol1.06507978
116MP0003656_abnormal_erythrocyte_physiolo1.05782927
117MP0009840_abnormal_foam_cell1.02672021
118MP0000631_abnormal_neuroendocrine_gland1.02498644
119MP0005058_abnormal_lysosome_morphology1.01615732
120MP0005620_abnormal_muscle_contractility1.00537180
121MP0003787_abnormal_imprinting0.99896289
122MP0010352_gastrointestinal_tract_polyps0.99823913
123MP0003123_paternal_imprinting0.99655712
124MP0006138_congestive_heart_failure0.99179420
125MP0004233_abnormal_muscle_weight0.99040736
126MP0002102_abnormal_ear_morphology0.98158673
127MP0003115_abnormal_respiratory_system0.96792980
128MP0008961_abnormal_basal_metabolism0.96216894
129MP0003385_abnormal_body_wall0.96166921
130MP0009672_abnormal_birth_weight0.95644647
131MP0001905_abnormal_dopamine_level0.95286093
132MP0001177_atelectasis0.95162894
133MP0002269_muscular_atrophy0.95078770
134MP0000537_abnormal_urethra_morphology0.94511584
135MP0002229_neurodegeneration0.94376590
136MP0001502_abnormal_circadian_rhythm0.93481008
137MP0003634_abnormal_glial_cell0.92317879
138MP0005666_abnormal_adipose_tissue0.92257027
139MP0009053_abnormal_anal_canal0.92192564
140MP0002972_abnormal_cardiac_muscle0.92182613
141MP0002161_abnormal_fertility/fecundity0.91783287
142MP0006292_abnormal_olfactory_placode0.90535130
143MP0004145_abnormal_muscle_electrophysio0.90230683
144MP0003453_abnormal_keratinocyte_physiol0.90106600
145MP0004085_abnormal_heartbeat0.89705649
146MP0002210_abnormal_sex_determination0.87864759
147MP0001730_embryonic_growth_arrest0.86757012
148MP0005621_abnormal_cell_physiology0.86194018
149MP0003646_muscle_fatigue0.85213013
150MP0005551_abnormal_eye_electrophysiolog0.83522290
151MP0003122_maternal_imprinting0.83405530
152MP0002925_abnormal_cardiovascular_devel0.82401316
153MP0001542_abnormal_bone_strength0.82256443
154MP0004742_abnormal_vestibular_system0.80225203
155MP0002128_abnormal_blood_circulation0.79175455
156MP0002638_abnormal_pupillary_reflex0.77833748
157MP0002069_abnormal_eating/drinking_beha0.77650598
158MP0003690_abnormal_glial_cell0.76930673
159MP0003828_pulmonary_edema0.76766820
160MP0002752_abnormal_somatic_nervous0.76410138
161MP0004885_abnormal_endolymph0.76376766
162MP0005508_abnormal_skeleton_morphology0.76335785
163MP0003879_abnormal_hair_cell0.75321594
164MP0002114_abnormal_axial_skeleton0.74981089
165MP0003172_abnormal_lysosome_physiology0.74678091
166MP0001614_abnormal_blood_vessel0.72962365
167MP0000013_abnormal_adipose_tissue0.71399633
168MP0000266_abnormal_heart_morphology0.70821175
169* MP0001145_abnormal_male_reproductive0.69569838
170MP0000432_abnormal_head_morphology0.69163557
171MP0002998_abnormal_bone_remodeling0.68937188
172MP0003045_fibrosis0.68732906
173MP0005394_taste/olfaction_phenotype0.68138400
174MP0005499_abnormal_olfactory_system0.68138400
175MP0004197_abnormal_fetal_growth/weight/0.68049038
176MP0003221_abnormal_cardiomyocyte_apopto0.67845366
177MP0003890_abnormal_embryonic-extraembry0.67827801
178MP0001986_abnormal_taste_sensitivity0.67478038
179MP0001661_extended_life_span0.66577446
180MP0003861_abnormal_nervous_system0.65805112
181MP0003283_abnormal_digestive_organ0.65595705
182MP0005197_abnormal_uvea_morphology0.65446669
183MP0001243_abnormal_dermal_layer0.65371552

Predicted human phenotypes

RankGene SetZ-score
1Insomnia (HP:0100785)6.57945049
2Overriding aorta (HP:0002623)6.56830406
3Elfin facies (HP:0004428)6.49863136
4Hyperacusis (HP:0010780)6.39629095
5Sensory axonal neuropathy (HP:0003390)6.28836501
6Renovascular hypertension (HP:0100817)6.01831931
7Absent/shortened dynein arms (HP:0200106)5.99947178
8Dynein arm defect of respiratory motile cilia (HP:0012255)5.99947178
9Toxemia of pregnancy (HP:0100603)5.98409368
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.94962017
11Flat cornea (HP:0007720)5.48870728
12Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)5.27697550
13Renal duplication (HP:0000075)5.21085603
14Protrusio acetabuli (HP:0003179)5.10632656
15Abnormal respiratory motile cilium physiology (HP:0012261)4.60434120
16Abnormal respiratory epithelium morphology (HP:0012253)4.50157979
17Abnormal respiratory motile cilium morphology (HP:0005938)4.50157979
18Premature rupture of membranes (HP:0001788)4.41384433
19Rhinitis (HP:0012384)4.20362777
20Type 1 muscle fiber predominance (HP:0003803)4.18756013
21Abnormality of the diencephalon (HP:0010662)4.03386261
22Polygenic inheritance (HP:0010982)4.00051321
23Hyporeflexia of lower limbs (HP:0002600)3.89518039
24Abnormal ciliary motility (HP:0012262)3.68043881
25Bowel diverticulosis (HP:0005222)3.47815900
26Truncal ataxia (HP:0002078)3.44103463
27Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.43979976
28Nemaline bodies (HP:0003798)3.41774644
29Bladder diverticulum (HP:0000015)3.36859036
30Muscle fiber inclusion bodies (HP:0100299)3.35601057
31Curly hair (HP:0002212)3.23656846
32Increased nuchal translucency (HP:0010880)3.13359031
33Myokymia (HP:0002411)3.13352702
34Increased variability in muscle fiber diameter (HP:0003557)3.08544252
35Arterial tortuosity (HP:0005116)3.04736335
36Abnormality of skeletal muscle fiber size (HP:0012084)3.00911440
37Vascular tortuosity (HP:0004948)2.98106329
38Round ear (HP:0100830)2.96464287
39Chronic bronchitis (HP:0004469)2.94490838
40Megalocornea (HP:0000485)2.93915591
41Focal motor seizures (HP:0011153)2.92441066
42Atrophic scars (HP:0001075)2.87487739
43Increased connective tissue (HP:0009025)2.87450695
44Exercise-induced myalgia (HP:0003738)2.83304491
45Aortic dissection (HP:0002647)2.79479980
46Steppage gait (HP:0003376)2.75599909
47Centrally nucleated skeletal muscle fibers (HP:0003687)2.72599394
48Fragile skin (HP:0001030)2.70512724
49Spinal rigidity (HP:0003306)2.64048995
50Focal seizures (HP:0007359)2.63382149
51Pheochromocytoma (HP:0002666)2.63183608
52Mildly elevated creatine phosphokinase (HP:0008180)2.62355322
53Morphological abnormality of the pyramidal tract (HP:0002062)2.61654204
54Shallow orbits (HP:0000586)2.60458737
55Aortic aneurysm (HP:0004942)2.59552139
56Pointed chin (HP:0000307)2.59344625
57Hypercalcemia (HP:0003072)2.59153243
58Ulnar deviation of the wrist (HP:0003049)2.56589655
59Distal lower limb muscle weakness (HP:0009053)2.52140931
60Distal lower limb amyotrophy (HP:0008944)2.52024484
61Ulnar bowing (HP:0003031)2.49988751
62Obsessive-compulsive behavior (HP:0000722)2.48228553
63Obstructive sleep apnea (HP:0002870)2.46467710
64Vertebral compression fractures (HP:0002953)2.46445358
65Mitral regurgitation (HP:0001653)2.43745515
66Visual hallucinations (HP:0002367)2.43029658
67Cerebral aneurysm (HP:0004944)2.42502016
68Ankle contracture (HP:0006466)2.41402409
69Progressive cerebellar ataxia (HP:0002073)2.41094410
70Retinal dysplasia (HP:0007973)2.38503452
71Neuroendocrine neoplasm (HP:0100634)2.38186633
72Calcaneovalgus deformity (HP:0001848)2.34913786
73Neonatal short-limb short stature (HP:0008921)2.34372934
74Abnormality of the calcaneus (HP:0008364)2.33027839
75Myopathic facies (HP:0002058)2.32792749
76Areflexia of lower limbs (HP:0002522)2.31732241
77Mitral valve prolapse (HP:0001634)2.30523850
78Deformed tarsal bones (HP:0008119)2.30508713
79Dilatation of the ascending aorta (HP:0005111)2.30248700
80Patellar dislocation (HP:0002999)2.29549463
81Type II lissencephaly (HP:0007260)2.28247309
82Epileptic encephalopathy (HP:0200134)2.27034530
83Hypercalciuria (HP:0002150)2.25289080
84Wormian bones (HP:0002645)2.24116483
85Gait imbalance (HP:0002141)2.23945274
86Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.23647313
87Abnormality of the carotid arteries (HP:0005344)2.23073377
88Chronic otitis media (HP:0000389)2.23056044
89Achilles tendon contracture (HP:0001771)2.22612444
90Febrile seizures (HP:0002373)2.22490428
91Distal arthrogryposis (HP:0005684)2.19903511
92Ankle clonus (HP:0011448)2.19199106
93Thin ribs (HP:0000883)2.16555675
94Lower limb amyotrophy (HP:0007210)2.16306242
95Abnormality of dentin (HP:0010299)2.15352650
96Slender build (HP:0001533)2.11726658
97Disproportionate tall stature (HP:0001519)2.11281045
98Genu recurvatum (HP:0002816)2.10685407
99Medial flaring of the eyebrow (HP:0010747)2.10633129
100Urinary urgency (HP:0000012)2.10548213
101Abnormality of the Achilles tendon (HP:0005109)2.10094699
102Biconcave vertebral bodies (HP:0004586)2.09982522
103Dislocated radial head (HP:0003083)2.08597871
104Arnold-Chiari malformation (HP:0002308)2.05839226
105Nasal polyposis (HP:0100582)2.04856069
106Blue sclerae (HP:0000592)2.03972380
107Distal upper limb amyotrophy (HP:0007149)2.03961595
108Upper limb amyotrophy (HP:0009129)2.03961595
109Difficulty running (HP:0009046)2.03884133
110Vertebral arch anomaly (HP:0008438)2.03519623
111Supranuclear gaze palsy (HP:0000605)2.02470199
112Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02373623
113Degeneration of the lateral corticospinal tracts (HP:0002314)2.02373623
114Chronic sinusitis (HP:0011109)2.01555949
115Deep venous thrombosis (HP:0002625)2.01220465
116Generalized amyotrophy (HP:0003700)2.00849444
117Insidious onset (HP:0003587)2.00204422
118Termporal pattern (HP:0011008)2.00204422
119Abnormality of the corticospinal tract (HP:0002492)2.00194802
120Aneurysm (HP:0002617)2.00021446
121Megalencephaly (HP:0001355)1.99638867
122Spinal cord lesions (HP:0100561)1.98111483
123Syringomyelia (HP:0003396)1.98111483
124Scapular winging (HP:0003691)1.97464879
125Difficulty climbing stairs (HP:0003551)1.95554744
126Hyperextensible skin (HP:0000974)1.95478445
127Impaired vibration sensation in the lower limbs (HP:0002166)1.95097604
128Atonic seizures (HP:0010819)1.94907646
129Broad face (HP:0000283)1.94236705
130Spastic paraplegia (HP:0001258)1.93341805
131Soft skin (HP:0000977)1.93070832
132Infertility (HP:0000789)1.91715046
133Spastic gait (HP:0002064)1.91522283
134Congenital primary aphakia (HP:0007707)1.90807683
135Short nail (HP:0001799)1.90763197
136Subaortic stenosis (HP:0001682)1.90213945
137Abnormality of the left ventricular outflow tract (HP:0011103)1.90213945
138Asymmetry of the thorax (HP:0001555)1.89764006
139Anosmia (HP:0000458)1.89129635
140Abnormality of the radial head (HP:0003995)1.88409058
141Cervical subluxation (HP:0003308)1.88030389
142Lower limb muscle weakness (HP:0007340)1.87290793
143Paraplegia (HP:0010550)1.86546919
144Asymmetric septal hypertrophy (HP:0001670)1.86486097
145Peritonitis (HP:0002586)1.86389477
146Back pain (HP:0003418)1.85412777
147Generalized myoclonic seizures (HP:0002123)1.85372919
148EMG: myopathic abnormalities (HP:0003458)1.84493289
149Nephronophthisis (HP:0000090)1.83902840
150Elbow flexion contracture (HP:0002987)1.83135011
151Osteolytic defects of the phalanges of the hand (HP:0009771)1.82642801
152Osteolytic defects of the hand bones (HP:0009699)1.82642801
153Turricephaly (HP:0000262)1.81125459
154Sacral dimple (HP:0000960)1.80693849
155Calf muscle hypertrophy (HP:0008981)1.80133607
156Breech presentation (HP:0001623)1.79638368
157Periorbital edema (HP:0100539)1.78714084
158Progressive muscle weakness (HP:0003323)1.78696465
159Rectal prolapse (HP:0002035)1.78253650
160Pterygium (HP:0001059)1.76075542
161Hallux valgus (HP:0001822)1.75670672
162Multifactorial inheritance (HP:0001426)1.73687081
163Overgrowth (HP:0001548)1.73652858
164Abnormality of oral frenula (HP:0000190)1.73287872
165Long palpebral fissure (HP:0000637)1.73157946
166Abnormal ossification of hand bones (HP:0005921)1.73144801
167Generalized tonic-clonic seizures (HP:0002069)1.73081809
168Precocious puberty (HP:0000826)1.72142123
169Broad metatarsal (HP:0001783)1.72051917
170Neurofibrillary tangles (HP:0002185)1.71946717
171Aortic regurgitation (HP:0001659)1.71032169
172Adducted thumb (HP:0001181)1.70066174
173Cerebral inclusion bodies (HP:0100314)1.69288631
174Abnormality of carpal bone ossification (HP:0006257)1.69246424
175Joint laxity (HP:0001388)1.68878994
176Muscle hypertrophy of the lower extremities (HP:0008968)1.68805264
177Flat acetabular roof (HP:0003180)1.68671579
178Impaired smooth pursuit (HP:0007772)1.67128575
179Muscle fiber splitting (HP:0003555)1.66974555
180Facial edema (HP:0000282)1.66378488
181Urinary bladder sphincter dysfunction (HP:0002839)1.66322988
182Nephrogenic diabetes insipidus (HP:0009806)1.65475560
183Hemiparesis (HP:0001269)1.65322781
184Posterior embryotoxon (HP:0000627)1.64932549
185Nephrocalcinosis (HP:0000121)1.64212857
186Ankyloglossia (HP:0010296)1.63528303
187Abnormality of the line of Schwalbe (HP:0008048)1.62226582
188Gaze-evoked nystagmus (HP:0000640)1.61481598
189Hypoplasia of the brainstem (HP:0002365)1.61385809
190Aplasia/Hypoplasia of the brainstem (HP:0007362)1.61385809
191Deviation of the hallux (HP:0010051)1.59672945
192Dysmetria (HP:0001310)1.59176215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K95.28855489
2PDK44.60812900
3PDK34.60812900
4TRIB33.99732271
5NTRK33.72883722
6TTN3.56724884
7PDGFRA2.88282370
8MARK12.79516495
9PDK22.73558105
10PRKD32.63539156
11CDK122.55725515
12YES12.53576877
13EPHA42.41699539
14RIPK12.40259405
15TNIK2.28168701
16SMG12.19260140
17LATS22.15798702
18ERN12.13119055
19MAP3K42.10648345
20MAP3K132.10497112
21SIK12.07695261
22EEF2K2.05230557
23MAP2K72.02864446
24FGFR41.85272271
25NTRK11.71400415
26MOS1.69718840
27MINK11.69386775
28PRKD21.65711428
29MAP3K101.56736891
30NTRK21.53181979
31IRAK31.52800933
32NEK91.52136610
33BMPR1B1.49590694
34PDGFRB1.47003525
35PTK21.45445137
36SGK2231.44184468
37SGK4941.44184468
38PRPF4B1.43832052
39STK391.40624507
40MAP2K31.35480324
41ZAK1.28407256
42GRK51.26335590
43DAPK21.25236462
44DDR21.22927445
45MAPK131.22517401
46PLK21.22259192
47AKT31.21808719
48UHMK11.20185886
49MTOR1.15951647
50PKN11.13346772
51CDK51.10335711
52ARAF1.10037353
53PHKG21.08837394
54PHKG11.08837394
55PAK41.08189236
56PAK61.07526942
57PKN21.06347537
58SGK21.05730168
59PAK21.04735956
60SCYL21.04327769
61PTK2B1.02818627
62WNK10.98568485
63ICK0.97287940
64MUSK0.97226395
65CAMKK10.96271496
66CASK0.95214428
67MAP3K70.93424638
68MAP3K20.92393491
69LIMK10.91605704
70GRK10.90240314
71ROCK20.86697035
72MET0.85316635
73MARK20.84075597
74TESK20.82733295
75WNK40.81463424
76MAP2K40.80380071
77BRAF0.77565738
78SGK30.76883012
79CAMK2A0.75936940
80STK380.74890906
81FES0.74352684
82LMTK20.73907268
83ERBB40.73832128
84MAP3K80.73541991
85OXSR10.73214674
86EPHB10.73170010
87EPHA20.72163356
88BMX0.71848793
89LATS10.71468612
90PRKCG0.70843927
91SGK10.68981853
92PRKCH0.67921828
93FGFR30.67535655
94BRD40.66681677
95NEK60.65148513
96MAPK120.63806324
97PTK60.62615585
98TYRO30.61745606
99CAMK1G0.61352874
100TNK20.61297714
101TAOK10.60875744
102TRPM70.60617202
103PDK10.60512148
104MAPK110.60397266
105PAK30.60316930
106CDK180.56888143
107TAOK20.56612494
108KSR20.56139871
109ROCK10.56013944
110CDK150.55828014
111CDK140.55505631
112RET0.55441954
113HCK0.55378954
114CAMK2B0.55319292
115DYRK20.54861350
116PRKG10.54286378
117DYRK1A0.54011663
118SIK20.53084932
119MAP3K140.52157369
120TESK10.52117988
121RPS6KC10.51565046
122RPS6KL10.51565046
123MAPKAPK50.50773607
124MAP3K60.50529399
125RPS6KA20.50509530
126DMPK0.49897555
127PNCK0.49307321
128FYN0.48115744
129MAPK100.48002476
130STK110.46427911
131TGFBR20.45526506
132ZAP700.44688083
133CDC42BPA0.44160717
134MAP3K30.44144686
135PRKCQ0.44088969
136MAPK70.43368789
137DYRK1B0.43030521
138CAMK1D0.42408017
139OBSCN0.42291830
140SYK0.41781705
141LRRK20.41728296
142FGFR20.41365396
143CAMK2D0.40002476
144MELK0.39352885
145ALK0.38773002
146RAF10.38356624
147STK100.38110732
148FGFR10.38011791
149CDK11A0.37877978
150AKT20.37538339
151MYLK0.36811016
152BRSK10.36733211
153EGFR0.36625458
154PRKCE0.34384112
155RPS6KA30.31760554
156FGR0.30161708
157PRKACB0.29392124
158HIPK20.29308196
159PRKAA10.29214775
160BCR0.28598261
161KSR10.28356931
162PDPK10.27893508
163CSNK1G20.27821825
164PRKCZ0.27456922
165PRKCB0.25041053

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.60578152
2Synaptic vesicle cycle_Homo sapiens_hsa047212.57203393
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.30249506
4Circadian entrainment_Homo sapiens_hsa047132.26957428
5Long-term potentiation_Homo sapiens_hsa047202.19137145
6Gastric acid secretion_Homo sapiens_hsa049712.15898001
7Morphine addiction_Homo sapiens_hsa050322.15711782
8Amphetamine addiction_Homo sapiens_hsa050312.12277521
9Glutamatergic synapse_Homo sapiens_hsa047242.10773897
10Olfactory transduction_Homo sapiens_hsa047402.03403770
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.03371704
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.00199731
13GABAergic synapse_Homo sapiens_hsa047271.98351433
14Insulin secretion_Homo sapiens_hsa049111.90462093
15Focal adhesion_Homo sapiens_hsa045101.86781743
16Dopaminergic synapse_Homo sapiens_hsa047281.85501741
17Dorso-ventral axis formation_Homo sapiens_hsa043201.81852438
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77793171
19Central carbon metabolism in cancer_Homo sapiens_hsa052301.74724570
20Taste transduction_Homo sapiens_hsa047421.73269748
21Phosphatidylinositol signaling system_Homo sapiens_hsa040701.71941942
22ECM-receptor interaction_Homo sapiens_hsa045121.71795627
23Renin secretion_Homo sapiens_hsa049241.68161990
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64165831
25Cholinergic synapse_Homo sapiens_hsa047251.60627432
26Salivary secretion_Homo sapiens_hsa049701.59885302
27ErbB signaling pathway_Homo sapiens_hsa040121.59341317
28Proteoglycans in cancer_Homo sapiens_hsa052051.54231687
29Bladder cancer_Homo sapiens_hsa052191.54046188
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53627367
31Serotonergic synapse_Homo sapiens_hsa047261.52899223
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.51138647
33Long-term depression_Homo sapiens_hsa047301.49680710
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47464005
35Prion diseases_Homo sapiens_hsa050201.47394657
36Alcoholism_Homo sapiens_hsa050341.44689694
37Adherens junction_Homo sapiens_hsa045201.42688479
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.41972330
39Cocaine addiction_Homo sapiens_hsa050301.39035308
40Oxytocin signaling pathway_Homo sapiens_hsa049211.37500763
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36876421
42Thyroid cancer_Homo sapiens_hsa052161.35545424
43Small cell lung cancer_Homo sapiens_hsa052221.33959535
44Cardiac muscle contraction_Homo sapiens_hsa042601.31919919
45Calcium signaling pathway_Homo sapiens_hsa040201.31186468
46Pancreatic cancer_Homo sapiens_hsa052121.31148265
47Notch signaling pathway_Homo sapiens_hsa043301.27061420
48mTOR signaling pathway_Homo sapiens_hsa041501.25147706
49Acute myeloid leukemia_Homo sapiens_hsa052211.24655790
50Type II diabetes mellitus_Homo sapiens_hsa049301.22746554
51MicroRNAs in cancer_Homo sapiens_hsa052061.22512550
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20623321
53Collecting duct acid secretion_Homo sapiens_hsa049661.17718361
54Axon guidance_Homo sapiens_hsa043601.13606796
55Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12904785
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11821464
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10434478
58Gap junction_Homo sapiens_hsa045401.09529303
59Pentose phosphate pathway_Homo sapiens_hsa000301.09377707
60cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06650621
61Amoebiasis_Homo sapiens_hsa051461.02295771
62Estrogen signaling pathway_Homo sapiens_hsa049151.01882731
63Glucagon signaling pathway_Homo sapiens_hsa049221.01338822
64Colorectal cancer_Homo sapiens_hsa052101.00596937
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99683484
66Prostate cancer_Homo sapiens_hsa052150.99132620
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98473239
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97893666
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.95850398
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.95713150
71cAMP signaling pathway_Homo sapiens_hsa040240.94983058
72Oocyte meiosis_Homo sapiens_hsa041140.94366142
73Glioma_Homo sapiens_hsa052140.93989380
74B cell receptor signaling pathway_Homo sapiens_hsa046620.93610669
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93563697
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92995843
77Other glycan degradation_Homo sapiens_hsa005110.92946241
78GnRH signaling pathway_Homo sapiens_hsa049120.91832971
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90794235
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.89866550
81Steroid biosynthesis_Homo sapiens_hsa001000.89733847
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89013063
83Prolactin signaling pathway_Homo sapiens_hsa049170.87482670
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86872882
85Hippo signaling pathway_Homo sapiens_hsa043900.86850410
86Systemic lupus erythematosus_Homo sapiens_hsa053220.85934994
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.85658339
88Ether lipid metabolism_Homo sapiens_hsa005650.85034914
89Dilated cardiomyopathy_Homo sapiens_hsa054140.82823765
90Inositol phosphate metabolism_Homo sapiens_hsa005620.82308168
91Melanogenesis_Homo sapiens_hsa049160.81347355
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81314605
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80741589
94Apoptosis_Homo sapiens_hsa042100.80296021
95Melanoma_Homo sapiens_hsa052180.79792067
96Biosynthesis of amino acids_Homo sapiens_hsa012300.78063478
97Insulin resistance_Homo sapiens_hsa049310.77942553
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76784196
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75367905
100Pathways in cancer_Homo sapiens_hsa052000.74566032
101MAPK signaling pathway_Homo sapiens_hsa040100.72548415
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71224773
103HIF-1 signaling pathway_Homo sapiens_hsa040660.71031415
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70536951
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.70474639
106T cell receptor signaling pathway_Homo sapiens_hsa046600.69377664
107Insulin signaling pathway_Homo sapiens_hsa049100.68665454
108Vibrio cholerae infection_Homo sapiens_hsa051100.68429169
109Thyroid hormone synthesis_Homo sapiens_hsa049180.68199587
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67137669
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66852283
112FoxO signaling pathway_Homo sapiens_hsa040680.66378811
113Hepatitis B_Homo sapiens_hsa051610.66308230
114Tight junction_Homo sapiens_hsa045300.66208852
115Endocytosis_Homo sapiens_hsa041440.65025266
116Renal cell carcinoma_Homo sapiens_hsa052110.63449213
117Shigellosis_Homo sapiens_hsa051310.63329910
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62736443
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62274994
120HTLV-I infection_Homo sapiens_hsa051660.61883607
121Vitamin B6 metabolism_Homo sapiens_hsa007500.61673144
122Fructose and mannose metabolism_Homo sapiens_hsa000510.61026283
123Alzheimers disease_Homo sapiens_hsa050100.60434554
124Pancreatic secretion_Homo sapiens_hsa049720.60089913
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59746291
126Choline metabolism in cancer_Homo sapiens_hsa052310.58742377
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58267503
128TNF signaling pathway_Homo sapiens_hsa046680.56642702
129Huntingtons disease_Homo sapiens_hsa050160.56129504
130Basal cell carcinoma_Homo sapiens_hsa052170.54131450
131Viral carcinogenesis_Homo sapiens_hsa052030.53943782
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52538434
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50629457
134Ras signaling pathway_Homo sapiens_hsa040140.49941016
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49921383
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.49833367
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.49344073
138Chronic myeloid leukemia_Homo sapiens_hsa052200.47181642
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47092835
140Type I diabetes mellitus_Homo sapiens_hsa049400.47051436
141Endometrial cancer_Homo sapiens_hsa052130.44660999
142VEGF signaling pathway_Homo sapiens_hsa043700.44300859
143N-Glycan biosynthesis_Homo sapiens_hsa005100.44025148
144Glycerolipid metabolism_Homo sapiens_hsa005610.43790778
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42658961
146Rap1 signaling pathway_Homo sapiens_hsa040150.41924846
147Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41113877
148Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36553553
149Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35100481
150Non-small cell lung cancer_Homo sapiens_hsa052230.34765277
151AMPK signaling pathway_Homo sapiens_hsa041520.34723659
152Wnt signaling pathway_Homo sapiens_hsa043100.33868177
153Ovarian steroidogenesis_Homo sapiens_hsa049130.33582696
154Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33009882

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