

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | sarcomere organization (GO:0045214) | 9.21295781 |
| 2 | actin-myosin filament sliding (GO:0033275) | 8.22575158 |
| 3 | muscle filament sliding (GO:0030049) | 8.22575158 |
| 4 | cardiac myofibril assembly (GO:0055003) | 7.91259491 |
| 5 | myofibril assembly (GO:0030239) | 7.78361947 |
| 6 | regulation of skeletal muscle contraction (GO:0014819) | 7.50744043 |
| 7 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 7.32302285 |
| 8 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 7.27794885 |
| 9 | plasma membrane repair (GO:0001778) | 6.80287755 |
| 10 | actin-mediated cell contraction (GO:0070252) | 6.75438000 |
| 11 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 6.66588308 |
| 12 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 6.53599786 |
| 13 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 6.44889722 |
| 14 | cardiac muscle contraction (GO:0060048) | 6.43875698 |
| 15 | tricarboxylic acid cycle (GO:0006099) | 6.31468219 |
| 16 | skeletal muscle fiber development (GO:0048741) | 6.26306731 |
| 17 | regulation of relaxation of muscle (GO:1901077) | 5.99822268 |
| 18 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 5.97841474 |
| 19 | regulation of actin filament-based movement (GO:1903115) | 5.90483045 |
| 20 | cardiac muscle cell development (GO:0055013) | 5.89491955 |
| 21 | actomyosin structure organization (GO:0031032) | 5.78215060 |
| 22 | striated muscle contraction (GO:0006941) | 5.76858289 |
| 23 | carnitine shuttle (GO:0006853) | 5.68109255 |
| 24 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 5.67124877 |
| 25 | myotube cell development (GO:0014904) | 5.62748428 |
| 26 | cardiac cell development (GO:0055006) | 5.52447883 |
| 27 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 5.48540358 |
| 28 | regulation of cell communication by electrical coupling (GO:0010649) | 5.42861969 |
| 29 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 5.35036794 |
| 30 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 5.27099622 |
| 31 | skeletal muscle contraction (GO:0003009) | 5.23602393 |
| 32 | adult heart development (GO:0007512) | 5.18931925 |
| 33 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 5.16154162 |
| 34 | cardiac muscle tissue morphogenesis (GO:0055008) | 5.14489768 |
| 35 | actin filament-based movement (GO:0030048) | 5.06794996 |
| 36 | ventricular cardiac muscle cell action potential (GO:0086005) | 5.06403933 |
| 37 | cardiac muscle hypertrophy (GO:0003300) | 5.03933804 |
| 38 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 5.02733172 |
| 39 | creatine metabolic process (GO:0006600) | 4.94926796 |
| 40 | glucan biosynthetic process (GO:0009250) | 4.90802204 |
| 41 | glycogen biosynthetic process (GO:0005978) | 4.90802204 |
| 42 | fatty acid transmembrane transport (GO:1902001) | 4.87621030 |
| 43 | heart contraction (GO:0060047) | 4.87570285 |
| 44 | heart process (GO:0003015) | 4.87570285 |
| 45 | striated muscle hypertrophy (GO:0014897) | 4.86565923 |
| 46 | cellular polysaccharide catabolic process (GO:0044247) | 4.85983492 |
| 47 | regulation of sarcomere organization (GO:0060297) | 4.85686792 |
| 48 | regulation of striated muscle contraction (GO:0006942) | 4.84950496 |
| 49 | muscle fiber development (GO:0048747) | 4.81759806 |
| 50 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 4.75297197 |
| 51 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 4.73347577 |
| 52 | muscle tissue morphogenesis (GO:0060415) | 4.69508058 |
| 53 | regulation of coenzyme metabolic process (GO:0051196) | 4.68065275 |
| 54 | regulation of cofactor metabolic process (GO:0051193) | 4.68065275 |
| 55 | heart trabecula formation (GO:0060347) | 4.67655212 |
| 56 | skeletal muscle tissue development (GO:0007519) | 4.51828826 |
| 57 | skeletal muscle adaptation (GO:0043501) | 4.43167861 |
| 58 | regulation of membrane repolarization (GO:0060306) | 4.40584302 |
| 59 | polysaccharide catabolic process (GO:0000272) | 4.37865390 |
| 60 | muscle hypertrophy (GO:0014896) | 4.30554788 |
| 61 | skeletal muscle tissue regeneration (GO:0043403) | 4.21802397 |
| 62 | carnitine transmembrane transport (GO:1902603) | 4.20012148 |
| 63 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.15667367 |
| 64 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.10094303 |
| 65 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 4.09859879 |
| 66 | regulation of the force of heart contraction (GO:0002026) | 4.07896622 |
| 67 | muscle contraction (GO:0006936) | 4.06898482 |
| 68 | NADH metabolic process (GO:0006734) | 4.06311269 |
| 69 | 2-oxoglutarate metabolic process (GO:0006103) | 4.04991649 |
| 70 | regulation of sequestering of triglyceride (GO:0010889) | 4.00329075 |
| 71 | response to inactivity (GO:0014854) | 3.99267555 |
| 72 | muscle cell cellular homeostasis (GO:0046716) | 3.98811531 |
| 73 | fructose metabolic process (GO:0006000) | 3.93791866 |
| 74 | respiratory electron transport chain (GO:0022904) | 3.91371438 |
| 75 | glycogen metabolic process (GO:0005977) | 3.90653084 |
| 76 | cell communication involved in cardiac conduction (GO:0086065) | 3.89552870 |
| 77 | positive regulation of myotube differentiation (GO:0010831) | 3.87783629 |
| 78 | striated muscle adaptation (GO:0014888) | 3.87506175 |
| 79 | muscle organ morphogenesis (GO:0048644) | 3.86765630 |
| 80 | gluconeogenesis (GO:0006094) | 3.83684828 |
| 81 | glucan metabolic process (GO:0044042) | 3.83028194 |
| 82 | cellular glucan metabolic process (GO:0006073) | 3.83028194 |
| 83 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.83013160 |
| 84 | ATP synthesis coupled proton transport (GO:0015986) | 3.83013160 |
| 85 | muscle cell fate commitment (GO:0042693) | 3.82556394 |
| 86 | amino-acid betaine transport (GO:0015838) | 3.82119846 |
| 87 | carnitine transport (GO:0015879) | 3.82119846 |
| 88 | regulation of sulfur metabolic process (GO:0042762) | 3.81200709 |
| 89 | cardiac muscle adaptation (GO:0014887) | 3.81162415 |
| 90 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 3.81162415 |
| 91 | muscle hypertrophy in response to stress (GO:0003299) | 3.81162415 |
| 92 | electron transport chain (GO:0022900) | 3.79080109 |
| 93 | muscle system process (GO:0003012) | 3.77666721 |
| 94 | response to activity (GO:0014823) | 3.77382270 |
| 95 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.76574996 |
| 96 | muscle organ development (GO:0007517) | 3.74384338 |
| 97 | muscle structure development (GO:0061061) | 3.74255221 |
| 98 | regulation of cardiac muscle cell contraction (GO:0086004) | 3.73846540 |
| 99 | striated muscle cell development (GO:0055002) | 3.73299105 |
| 100 | oxidative phosphorylation (GO:0006119) | 3.71665457 |
| 101 | regulation of cardiac muscle contraction (GO:0055117) | 3.70431254 |
| 102 | glycogen catabolic process (GO:0005980) | 3.70146767 |
| 103 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 3.68751939 |
| 104 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 3.68751939 |
| 105 | regulation of ATPase activity (GO:0043462) | 3.68237927 |
| 106 | regulation of ATP catabolic process (GO:1903289) | 3.68237927 |
| 107 | response to muscle activity (GO:0014850) | 3.67444282 |
| 108 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.64827474 |
| 109 | positive regulation of cation channel activity (GO:2001259) | 3.64781730 |
| 110 | negative regulation of potassium ion transport (GO:0043267) | 3.62350860 |
| 111 | muscle adaptation (GO:0043500) | 3.61148582 |
| 112 | cardiac muscle cell action potential (GO:0086001) | 3.60792260 |
| 113 | negative regulation of protein localization to cell surface (GO:2000009) | 3.59806606 |
| 114 | regulation of heart rate (GO:0002027) | 3.59796165 |
| 115 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.58782021 |
| 116 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.58782021 |
| 117 | oxygen transport (GO:0015671) | 3.56869957 |
| 118 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 3.47175308 |
| 119 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.46703418 |
| 120 | glucan catabolic process (GO:0009251) | 3.44757917 |
| 121 | striated muscle atrophy (GO:0014891) | 3.44202676 |
| 122 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 3.42451500 |
| 123 | hexose biosynthetic process (GO:0019319) | 3.42377139 |
| 124 | neuronal action potential propagation (GO:0019227) | 3.39560052 |
| 125 | regulation of heart contraction (GO:0008016) | 3.36947146 |
| 126 | positive regulation of heart rate (GO:0010460) | 3.36498118 |
| 127 | relaxation of cardiac muscle (GO:0055119) | 3.35931249 |
| 128 | relaxation of muscle (GO:0090075) | 3.35878528 |
| 129 | myoblast fusion (GO:0007520) | 3.33076558 |
| 130 | regulation of muscle contraction (GO:0006937) | 3.32633677 |
| 131 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.31960814 |
| 132 | muscle cell development (GO:0055001) | 3.31182185 |
| 133 | oxaloacetate metabolic process (GO:0006107) | 3.28660914 |
| 134 | otic vesicle formation (GO:0030916) | 3.28542474 |
| 135 | ubiquinone biosynthetic process (GO:0006744) | 3.27830508 |
| 136 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 3.27403093 |
| 137 | regulation of muscle system process (GO:0090257) | 3.25105974 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 6.68321637 |
| 2 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 4.47763139 |
| 3 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 4.38363581 |
| 4 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 4.22535009 |
| 5 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 4.07060345 |
| 6 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 4.00160581 |
| 7 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 4.00160581 |
| 8 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.71219605 |
| 9 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 3.21533462 |
| 10 | ZNF263_19887448_ChIP-Seq_K562_Human | 3.16163987 |
| 11 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.13899528 |
| 12 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 2.82972212 |
| 13 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.78849035 |
| 14 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 2.51695765 |
| 15 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.33131388 |
| 16 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 2.23740342 |
| 17 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.04734618 |
| 18 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.03656594 |
| 19 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 2.01051212 |
| 20 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.99456352 |
| 21 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.86989354 |
| 22 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.78010750 |
| 23 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.74994669 |
| 24 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.72264260 |
| 25 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.68317427 |
| 26 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.67760722 |
| 27 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.63309218 |
| 28 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.61547095 |
| 29 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.57825748 |
| 30 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.54858910 |
| 31 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.48814474 |
| 32 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.45888006 |
| 33 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.45044274 |
| 34 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.41112176 |
| 35 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.40424070 |
| 36 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.39221495 |
| 37 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.39214465 |
| 38 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.37417580 |
| 39 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.33973982 |
| 40 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.33457571 |
| 41 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.30564277 |
| 42 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.29940451 |
| 43 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.28899573 |
| 44 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.26922414 |
| 45 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 1.25461590 |
| 46 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.23499012 |
| 47 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.21624879 |
| 48 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.20758527 |
| 49 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.20492560 |
| 50 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.18175893 |
| 51 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.16826543 |
| 52 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.15474559 |
| 53 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.15369390 |
| 54 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.14603488 |
| 55 | SPI1_20517297_ChIP-Seq_HL60_Human | 1.10136040 |
| 56 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.10092606 |
| 57 | P68_20966046_ChIP-Seq_HELA_Human | 1.09584921 |
| 58 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.08945135 |
| 59 | GATA1_22025678_ChIP-Seq_K562_Human | 1.08506463 |
| 60 | GATA1_19941826_ChIP-Seq_K562_Human | 1.08210188 |
| 61 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 1.06126716 |
| 62 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.05810272 |
| 63 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 1.05515954 |
| 64 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.04899311 |
| 65 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.04089783 |
| 66 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.04049872 |
| 67 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 1.04043596 |
| 68 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.01852831 |
| 69 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.99578793 |
| 70 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.99437512 |
| 71 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.98575919 |
| 72 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.98567041 |
| 73 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.98201551 |
| 74 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.98146645 |
| 75 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.98096163 |
| 76 | ATF3_27146783_Chip-Seq_COLON_Human | 0.97758871 |
| 77 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.97190648 |
| 78 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.97125639 |
| 79 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.95339621 |
| 80 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.94449949 |
| 81 | CTCF_21964334_Chip-Seq_Bcells_Human | 0.93637296 |
| 82 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.93608246 |
| 83 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.93536077 |
| 84 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.92848367 |
| 85 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.92681190 |
| 86 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.92572171 |
| 87 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.92150179 |
| 88 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.91788245 |
| 89 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.90801246 |
| 90 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.89966747 |
| 91 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.89691360 |
| 92 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.89221200 |
| 93 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.89124151 |
| 94 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.88320144 |
| 95 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.87396593 |
| 96 | GATA2_19941826_ChIP-Seq_K562_Human | 0.87200441 |
| 97 | SPI1_23127762_ChIP-Seq_K562_Human | 0.87047329 |
| 98 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.86284927 |
| 99 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.86091360 |
| 100 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.85926065 |
| 101 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.85517851 |
| 102 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 0.85135897 |
| 103 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.85006182 |
| 104 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.84974372 |
| 105 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.84065405 |
| 106 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.83846534 |
| 107 | SA1_27219007_Chip-Seq_Bcells_Human | 0.83792025 |
| 108 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.83617769 |
| 109 | PRDM14_21183938_ChIP-Seq_MESCs_Mouse | 0.82867060 |
| 110 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.82588430 |
| 111 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.82330097 |
| 112 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.82261088 |
| 113 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.81514115 |
| 114 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.81274438 |
| 115 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.81154347 |
| 116 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.80635729 |
| 117 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.80531064 |
| 118 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 0.79905897 |
| 119 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.79285974 |
| 120 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.79065634 |
| 121 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.78693506 |
| 122 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.78666405 |
| 123 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.78465968 |
| 124 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.77320315 |
| 125 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.76910995 |
| 126 | * RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.76556054 |
| 127 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 0.76224732 |
| 128 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.76090779 |
| 129 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.75888133 |
| 130 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.75632649 |
| 131 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.75453168 |
| 132 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.74544358 |
| 133 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.74540491 |
| 134 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 0.74513302 |
| 135 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.73577165 |
| 136 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.71140043 |
| 137 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.70903141 |
| 138 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 0.70008323 |
| 139 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.69434567 |
| 140 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.69102578 |
| 141 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.68666337 |
| 142 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.68383459 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002837_dystrophic_cardiac_calcinosis | 6.75233659 |
| 2 | MP0003646_muscle_fatigue | 6.52158399 |
| 3 | MP0000751_myopathy | 5.50807033 |
| 4 | MP0004084_abnormal_cardiac_muscle | 5.00653543 |
| 5 | MP0000749_muscle_degeneration | 4.53197739 |
| 6 | MP0004036_abnormal_muscle_relaxation | 4.36058711 |
| 7 | MP0004215_abnormal_myocardial_fiber | 4.20831931 |
| 8 | MP0005330_cardiomyopathy | 3.59874058 |
| 9 | MP0004145_abnormal_muscle_electrophysio | 3.42726407 |
| 10 | MP0004087_abnormal_muscle_fiber | 3.24232473 |
| 11 | MP0002106_abnormal_muscle_physiology | 2.96495126 |
| 12 | MP0000750_abnormal_muscle_regeneration | 2.95294331 |
| 13 | MP0004130_abnormal_muscle_cell | 2.87100534 |
| 14 | MP0005620_abnormal_muscle_contractility | 2.84953939 |
| 15 | MP0002972_abnormal_cardiac_muscle | 2.82475171 |
| 16 | MP0002269_muscular_atrophy | 2.66845337 |
| 17 | MP0000747_muscle_weakness | 2.56423268 |
| 18 | MP0003137_abnormal_impulse_conducting | 2.53836720 |
| 19 | MP0008775_abnormal_heart_ventricle | 2.48253379 |
| 20 | MP0000759_abnormal_skeletal_muscle | 2.45043621 |
| 21 | MP0005369_muscle_phenotype | 2.42298748 |
| 22 | MP0010630_abnormal_cardiac_muscle | 2.36993634 |
| 23 | MP0005385_cardiovascular_system_phenoty | 2.36792972 |
| 24 | MP0001544_abnormal_cardiovascular_syste | 2.36792972 |
| 25 | MP0004484_altered_response_of | 2.34181559 |
| 26 | MP0006138_congestive_heart_failure | 2.07425334 |
| 27 | MP0004233_abnormal_muscle_weight | 1.97129548 |
| 28 | MP0003828_pulmonary_edema | 1.88978365 |
| 29 | MP0003221_abnormal_cardiomyocyte_apopto | 1.88869788 |
| 30 | MP0006036_abnormal_mitochondrial_physio | 1.86942977 |
| 31 | MP0004085_abnormal_heartbeat | 1.78531018 |
| 32 | MP0002332_abnormal_exercise_endurance | 1.70417966 |
| 33 | MP0005666_abnormal_adipose_tissue | 1.61877450 |
| 34 | MP0004510_myositis | 1.59245013 |
| 35 | MP0002127_abnormal_cardiovascular_syste | 1.39431234 |
| 36 | MP0003950_abnormal_plasma_membrane | 1.32445151 |
| 37 | MP0004185_abnormal_adipocyte_glucose | 1.32291267 |
| 38 | MP0005670_abnormal_white_adipose | 1.29876608 |
| 39 | MP0004270_analgesia | 1.24297127 |
| 40 | MP0000343_altered_response_to | 1.21521725 |
| 41 | MP0002108_abnormal_muscle_morphology | 1.11956790 |
| 42 | MP0005375_adipose_tissue_phenotype | 1.09867816 |
| 43 | MP0006035_abnormal_mitochondrial_morpho | 1.04264141 |
| 44 | MP0000266_abnormal_heart_morphology | 1.03690917 |
| 45 | MP0002234_abnormal_pharynx_morphology | 1.02221563 |
| 46 | MP0003567_abnormal_fetal_cardiomyocyte | 1.01546152 |
| 47 | MP0001661_extended_life_span | 0.95558079 |
| 48 | MP0005266_abnormal_metabolism | 0.93697452 |
| 49 | MP0005165_increased_susceptibility_to | 0.92861885 |
| 50 | MP0000733_abnormal_muscle_development | 0.91661465 |
| 51 | MP0010368_abnormal_lymphatic_system | 0.83510334 |
| 52 | MP0003279_aneurysm | 0.83147679 |
| 53 | MP0009780_abnormal_chondrocyte_physiolo | 0.82051060 |
| 54 | MP0003806_abnormal_nucleotide_metabolis | 0.79104963 |
| 55 | MP0003705_abnormal_hypodermis_morpholog | 0.78845840 |
| 56 | MP0000230_abnormal_systemic_arterial | 0.75015770 |
| 57 | MP0002971_abnormal_brown_adipose | 0.74096745 |
| 58 | MP0002128_abnormal_blood_circulation | 0.68884901 |
| 59 | MP0004043_abnormal_pH_regulation | 0.67352431 |
| 60 | MP0004147_increased_porphyrin_level | 0.65744954 |
| 61 | MP0000372_irregular_coat_pigmentation | 0.62663883 |
| 62 | MP0000003_abnormal_adipose_tissue | 0.59869563 |
| 63 | MP0000013_abnormal_adipose_tissue | 0.58395645 |
| 64 | MP0002909_abnormal_adrenal_gland | 0.55856070 |
| 65 | MP0002078_abnormal_glucose_homeostasis | 0.54367693 |
| 66 | MP0001879_abnormal_lymphatic_vessel | 0.54032306 |
| 67 | MP0001299_abnormal_eye_distance/ | 0.53862658 |
| 68 | MP0003566_abnormal_cell_adhesion | 0.53498636 |
| 69 | MP0005623_abnormal_meninges_morphology | 0.52478834 |
| 70 | MP0000767_abnormal_smooth_muscle | 0.50807918 |
| 71 | MP0003879_abnormal_hair_cell | 0.50163385 |
| 72 | MP0008961_abnormal_basal_metabolism | 0.49945902 |
| 73 | MP0005319_abnormal_enzyme/_coenzyme | 0.49486663 |
| 74 | MP0005451_abnormal_body_composition | 0.48967298 |
| 75 | MP0002638_abnormal_pupillary_reflex | 0.48011000 |
| 76 | MP0004134_abnormal_chest_morphology | 0.46319107 |
| 77 | MP0005187_abnormal_penis_morphology | 0.45585248 |
| 78 | MP0001346_abnormal_lacrimal_gland | 0.40068989 |
| 79 | MP0005334_abnormal_fat_pad | 0.39979778 |
| 80 | MP0010030_abnormal_orbit_morphology | 0.39108916 |
| 81 | MP0005083_abnormal_biliary_tract | 0.38198579 |
| 82 | MP0009840_abnormal_foam_cell | 0.37090906 |
| 83 | MP0005535_abnormal_body_temperature | 0.36281940 |
| 84 | MP0002925_abnormal_cardiovascular_devel | 0.36076009 |
| 85 | MP0008438_abnormal_cutaneous_collagen | 0.35575268 |
| 86 | MP0005275_abnormal_skin_tensile | 0.34990070 |
| 87 | MP0000762_abnormal_tongue_morphology | 0.34669221 |
| 88 | MP0004142_abnormal_muscle_tone | 0.33763173 |
| 89 | MP0003656_abnormal_erythrocyte_physiolo | 0.31995193 |
| 90 | MP0005166_decreased_susceptibility_to | 0.31556806 |
| 91 | MP0003948_abnormal_gas_homeostasis | 0.30745054 |
| 92 | MP0005332_abnormal_amino_acid | 0.30078162 |
| 93 | MP0009672_abnormal_birth_weight | 0.29356275 |
| 94 | MP0002822_catalepsy | 0.29329508 |
| 95 | MP0001614_abnormal_blood_vessel | 0.28350306 |
| 96 | MP0002118_abnormal_lipid_homeostasis | 0.28250768 |
| 97 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.28093515 |
| 98 | MP0009115_abnormal_fat_cell | 0.27796825 |
| 99 | MP0002114_abnormal_axial_skeleton | 0.27786794 |
| 100 | MP0001853_heart_inflammation | 0.26845573 |
| 101 | MP0003195_calcinosis | 0.26340345 |
| 102 | MP0003045_fibrosis | 0.26070213 |
| 103 | MP0002896_abnormal_bone_mineralization | 0.25975937 |
| 104 | MP0005423_abnormal_somatic_nervous | 0.25961111 |
| 105 | MP0001784_abnormal_fluid_regulation | 0.25022594 |
| 106 | MP0009250_abnormal_appendicular_skeleto | 0.24144675 |
| 107 | MP0003984_embryonic_growth_retardation | 0.22976012 |
| 108 | MP0001727_abnormal_embryo_implantation | 0.22651019 |
| 109 | MP0005452_abnormal_adipose_tissue | 0.22209414 |
| 110 | MP0002088_abnormal_embryonic_growth/wei | 0.21761272 |
| 111 | MP0005167_abnormal_blood-brain_barrier | 0.21544566 |
| 112 | MP0000249_abnormal_blood_vessel | 0.21106029 |
| 113 | MP0005376_homeostasis/metabolism_phenot | 0.21104951 |
| 114 | MP0008569_lethality_at_weaning | 0.21101203 |
| 115 | MP0002734_abnormal_mechanical_nocicepti | 0.20874325 |
| 116 | MP0003959_abnormal_lean_body | 0.20679620 |
| 117 | MP0004272_abnormal_basement_membrane | 0.20366617 |
| 118 | MP0006276_abnormal_autonomic_nervous | 0.20016511 |
| 119 | MP0002066_abnormal_motor_capabilities/c | 0.19495619 |
| 120 | MP0004924_abnormal_behavior | 0.18833718 |
| 121 | MP0005386_behavior/neurological_phenoty | 0.18833718 |
| 122 | MP0005595_abnormal_vascular_smooth | 0.18732801 |
| 123 | MP0001943_abnormal_respiration | 0.17826583 |
| 124 | MP0002970_abnormal_white_adipose | 0.16829234 |
| 125 | MP0008874_decreased_physiological_sensi | 0.14986838 |
| 126 | MP0002067_abnormal_sensory_capabilities | 0.12831443 |
| 127 | MP0001529_abnormal_vocalization | 0.11908165 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Exercise-induced myalgia (HP:0003738) | 7.21911608 |
| 2 | Calf muscle hypertrophy (HP:0008981) | 7.08238413 |
| 3 | Exercise-induced muscle cramps (HP:0003710) | 7.05331869 |
| 4 | Sudden death (HP:0001699) | 7.03747233 |
| 5 | Muscle hypertrophy of the lower extremities (HP:0008968) | 6.93993347 |
| 6 | Ventricular tachycardia (HP:0004756) | 6.12945714 |
| 7 | Muscle fiber splitting (HP:0003555) | 6.07176220 |
| 8 | Myoglobinuria (HP:0002913) | 5.47921897 |
| 9 | Abnormality of the calf musculature (HP:0001430) | 5.38023175 |
| 10 | Hyporeflexia of lower limbs (HP:0002600) | 5.33693206 |
| 11 | Atrial fibrillation (HP:0005110) | 5.03222135 |
| 12 | Abnormality of the left ventricular outflow tract (HP:0011103) | 4.92731134 |
| 13 | Subaortic stenosis (HP:0001682) | 4.92731134 |
| 14 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 4.70894917 |
| 15 | Primary atrial arrhythmia (HP:0001692) | 4.70167981 |
| 16 | Lipoatrophy (HP:0100578) | 4.65672810 |
| 17 | EMG: myopathic abnormalities (HP:0003458) | 4.64043981 |
| 18 | Difficulty running (HP:0009046) | 4.56724989 |
| 19 | Muscle fiber inclusion bodies (HP:0100299) | 4.55260794 |
| 20 | Supraventricular tachycardia (HP:0004755) | 4.54525787 |
| 21 | Increased connective tissue (HP:0009025) | 4.44692677 |
| 22 | Supraventricular arrhythmia (HP:0005115) | 4.44690168 |
| 23 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 4.38786499 |
| 24 | Rhabdomyolysis (HP:0003201) | 4.30734332 |
| 25 | Bundle branch block (HP:0011710) | 4.15559723 |
| 26 | Right ventricular cardiomyopathy (HP:0011663) | 4.15234673 |
| 27 | Asymmetric septal hypertrophy (HP:0001670) | 4.14587213 |
| 28 | Myotonia (HP:0002486) | 4.03128986 |
| 29 | Dilated cardiomyopathy (HP:0001644) | 3.96894276 |
| 30 | Palpitations (HP:0001962) | 3.92551203 |
| 31 | Calcaneovalgus deformity (HP:0001848) | 3.87123929 |
| 32 | Syncope (HP:0001279) | 3.83350986 |
| 33 | Type 1 muscle fiber predominance (HP:0003803) | 3.75064388 |
| 34 | Nemaline bodies (HP:0003798) | 3.67254459 |
| 35 | Prolonged QT interval (HP:0001657) | 3.59887087 |
| 36 | Absent phalangeal crease (HP:0006109) | 3.50907593 |
| 37 | Muscle stiffness (HP:0003552) | 3.45855930 |
| 38 | Deformed tarsal bones (HP:0008119) | 3.42939185 |
| 39 | Heart block (HP:0012722) | 3.42576625 |
| 40 | Difficulty climbing stairs (HP:0003551) | 3.39341314 |
| 41 | Ventricular arrhythmia (HP:0004308) | 3.37888894 |
| 42 | Abnormal atrioventricular conduction (HP:0005150) | 3.22990166 |
| 43 | Atrioventricular block (HP:0001678) | 3.17468962 |
| 44 | Malignant hyperthermia (HP:0002047) | 3.02876607 |
| 45 | Increased variability in muscle fiber diameter (HP:0003557) | 2.96954900 |
| 46 | Ventricular fibrillation (HP:0001663) | 2.96790844 |
| 47 | Distal lower limb muscle weakness (HP:0009053) | 2.95920286 |
| 48 | Areflexia of lower limbs (HP:0002522) | 2.93383117 |
| 49 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.91990892 |
| 50 | Abnormal finger flexion creases (HP:0006143) | 2.89978208 |
| 51 | Neck muscle weakness (HP:0000467) | 2.76794161 |
| 52 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.72946986 |
| 53 | Acute necrotizing encephalopathy (HP:0006965) | 2.69443472 |
| 54 | Hepatic necrosis (HP:0002605) | 2.69118589 |
| 55 | Myopathic facies (HP:0002058) | 2.64237230 |
| 56 | Left ventricular hypertrophy (HP:0001712) | 2.62941157 |
| 57 | Abnormal EKG (HP:0003115) | 2.61099610 |
| 58 | Distal arthrogryposis (HP:0005684) | 2.60828489 |
| 59 | Limb-girdle muscle atrophy (HP:0003797) | 2.57944724 |
| 60 | Rimmed vacuoles (HP:0003805) | 2.57114554 |
| 61 | Ketoacidosis (HP:0001993) | 2.56867078 |
| 62 | Bulbar palsy (HP:0001283) | 2.52820358 |
| 63 | Round ear (HP:0100830) | 2.52215186 |
| 64 | Testicular atrophy (HP:0000029) | 2.41963411 |
| 65 | Weak cry (HP:0001612) | 2.41945855 |
| 66 | Hepatocellular necrosis (HP:0001404) | 2.37703364 |
| 67 | Slender build (HP:0001533) | 2.35823509 |
| 68 | Acute encephalopathy (HP:0006846) | 2.33606781 |
| 69 | Increased muscle lipid content (HP:0009058) | 2.30506763 |
| 70 | Hyperkalemia (HP:0002153) | 2.28577596 |
| 71 | Palmoplantar keratoderma (HP:0000982) | 2.28068444 |
| 72 | Distal lower limb amyotrophy (HP:0008944) | 2.27990821 |
| 73 | Hypoplastic ischia (HP:0003175) | 2.23253033 |
| 74 | Progressive macrocephaly (HP:0004481) | 2.22488215 |
| 75 | Muscular dystrophy (HP:0003560) | 2.21642878 |
| 76 | Hypoglycemic coma (HP:0001325) | 2.20550238 |
| 77 | Mitochondrial inheritance (HP:0001427) | 2.20034324 |
| 78 | EMG: neuropathic changes (HP:0003445) | 2.19951172 |
| 79 | Abnormality of the calcaneus (HP:0008364) | 2.18770548 |
| 80 | Abnormality of the neuromuscular junction (HP:0003398) | 2.18601343 |
| 81 | Fatigable weakness (HP:0003473) | 2.18601343 |
| 82 | Exercise intolerance (HP:0003546) | 2.15617892 |
| 83 | Spinal rigidity (HP:0003306) | 2.14421259 |
| 84 | Cerebral edema (HP:0002181) | 2.14402563 |
| 85 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.14185542 |
| 86 | Fetal akinesia sequence (HP:0001989) | 2.14184396 |
| 87 | Facial diplegia (HP:0001349) | 2.13785743 |
| 88 | Dicarboxylic aciduria (HP:0003215) | 2.11018305 |
| 89 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.11018305 |
| 90 | Hip contracture (HP:0003273) | 2.08783045 |
| 91 | Abnormality of alanine metabolism (HP:0010916) | 2.06802397 |
| 92 | Hyperalaninemia (HP:0003348) | 2.06802397 |
| 93 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.06802397 |
| 94 | Increased CSF lactate (HP:0002490) | 2.06303437 |
| 95 | Conjunctival hamartoma (HP:0100780) | 2.04866166 |
| 96 | Gowers sign (HP:0003391) | 2.02830012 |
| 97 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.02366980 |
| 98 | Increased intramyocellular lipid droplets (HP:0012240) | 2.00819942 |
| 99 | Waddling gait (HP:0002515) | 2.00732463 |
| 100 | Ulnar deviation of the wrist (HP:0003049) | 2.00442898 |
| 101 | Generalized muscle weakness (HP:0003324) | 1.99700160 |
| 102 | Proximal amyotrophy (HP:0007126) | 1.99524247 |
| 103 | Lower limb amyotrophy (HP:0007210) | 1.99480015 |
| 104 | Abnormality of the foot musculature (HP:0001436) | 1.97004647 |
| 105 | Ketosis (HP:0001946) | 1.95042989 |
| 106 | Abnormality of the shoulder girdle musculature (HP:0001435) | 1.94120317 |
| 107 | Frequent falls (HP:0002359) | 1.93944475 |
| 108 | Abnormality of the ischium (HP:0003174) | 1.93533625 |
| 109 | Foot dorsiflexor weakness (HP:0009027) | 1.93484321 |
| 110 | Lactic acidosis (HP:0003128) | 1.92275673 |
| 111 | Ragged-red muscle fibers (HP:0003200) | 1.90085113 |
| 112 | Scapular winging (HP:0003691) | 1.89061068 |
| 113 | Limb-girdle muscle weakness (HP:0003325) | 1.87841364 |
| 114 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.86697757 |
| 115 | Respiratory failure (HP:0002878) | 1.86104676 |
| 116 | Large for gestational age (HP:0001520) | 1.85171725 |
| 117 | Progressive muscle weakness (HP:0003323) | 1.85040603 |
| 118 | Congestive heart failure (HP:0001635) | 1.81256517 |
| 119 | Pheochromocytoma (HP:0002666) | 1.79129595 |
| 120 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.78625154 |
| 121 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.69965809 |
| 122 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.69965809 |
| 123 | Paralysis (HP:0003470) | 1.67609738 |
| 124 | Pelvic girdle muscle weakness (HP:0003749) | 1.62134508 |
| 125 | Shoulder girdle muscle weakness (HP:0003547) | 1.61981214 |
| 126 | Nonprogressive disorder (HP:0003680) | 1.56801228 |
| 127 | Long clavicles (HP:0000890) | 1.53003895 |
| 128 | Metatarsus adductus (HP:0001840) | 1.45732623 |
| 129 | Ulnar deviation of finger (HP:0009465) | 1.41350933 |
| 130 | Steppage gait (HP:0003376) | 1.38328755 |
| 131 | Limited hip movement (HP:0008800) | 1.37574679 |
| 132 | Popliteal pterygium (HP:0009756) | 1.35739956 |
| 133 | Type 2 muscle fiber atrophy (HP:0003554) | 1.34243927 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TTN | 6.94465238 |
| 2 | OBSCN | 5.24732089 |
| 3 | PHKG1 | 4.86606785 |
| 4 | PHKG2 | 4.86606785 |
| 5 | PDK3 | 3.26875788 |
| 6 | PDK4 | 3.26875788 |
| 7 | LMTK2 | 3.18091958 |
| 8 | DMPK | 2.89282174 |
| 9 | MYLK | 2.81109014 |
| 10 | BCKDK | 2.60329517 |
| 11 | TRIB3 | 2.52213824 |
| 12 | PKN2 | 2.46839372 |
| 13 | NEK1 | 2.29466646 |
| 14 | PINK1 | 2.28619843 |
| 15 | PIK3CA | 2.24036235 |
| 16 | MUSK | 2.22736340 |
| 17 | PDK2 | 2.04741996 |
| 18 | TIE1 | 1.63762730 |
| 19 | MAP2K3 | 1.48457150 |
| 20 | STK24 | 1.44058199 |
| 21 | MAP3K7 | 1.39223924 |
| 22 | NME1 | 1.37323833 |
| 23 | MAPK12 | 1.26619129 |
| 24 | GRK7 | 1.24637575 |
| 25 | PRKD1 | 1.12693378 |
| 26 | PAK3 | 1.09116531 |
| 27 | CAMK2D | 1.03691931 |
| 28 | MARK1 | 1.02491887 |
| 29 | LIMK1 | 0.98055538 |
| 30 | PIK3CG | 0.95245649 |
| 31 | PRKAA1 | 0.92793006 |
| 32 | MAPKAPK3 | 0.91622112 |
| 33 | PRKAA2 | 0.90618055 |
| 34 | ILK | 0.87309949 |
| 35 | MOS | 0.81246444 |
| 36 | DYRK1B | 0.80730265 |
| 37 | RIPK1 | 0.79871684 |
| 38 | FLT3 | 0.79695558 |
| 39 | ROCK1 | 0.78214200 |
| 40 | PKN1 | 0.77842707 |
| 41 | TRPM7 | 0.76462740 |
| 42 | STK4 | 0.75314346 |
| 43 | ZAK | 0.73824280 |
| 44 | MAP3K5 | 0.73464648 |
| 45 | MAP3K3 | 0.72626996 |
| 46 | TGFBR2 | 0.71526194 |
| 47 | CCNB1 | 0.71218749 |
| 48 | ERBB3 | 0.70543650 |
| 49 | INSRR | 0.69539452 |
| 50 | CDC42BPA | 0.66151154 |
| 51 | CAMK4 | 0.63525842 |
| 52 | WNK4 | 0.62303570 |
| 53 | EPHB1 | 0.61601047 |
| 54 | PDGFRA | 0.55552984 |
| 55 | NEK9 | 0.54783321 |
| 56 | MAPK4 | 0.51627874 |
| 57 | DAPK3 | 0.49959685 |
| 58 | MAP3K13 | 0.48547984 |
| 59 | MAP2K1 | 0.46852204 |
| 60 | PRKACB | 0.46697468 |
| 61 | RPS6KC1 | 0.46170171 |
| 62 | RPS6KL1 | 0.46170171 |
| 63 | CAMK2B | 0.46051768 |
| 64 | MAP2K4 | 0.45712794 |
| 65 | STK38L | 0.45408824 |
| 66 | ROCK2 | 0.44450677 |
| 67 | STK38 | 0.44174219 |
| 68 | KDR | 0.44002479 |
| 69 | WNK1 | 0.43947895 |
| 70 | CAMK2A | 0.43380056 |
| 71 | KSR2 | 0.42488368 |
| 72 | MAP2K6 | 0.41184974 |
| 73 | PDPK1 | 0.39356035 |
| 74 | RPS6KA6 | 0.39134126 |
| 75 | ICK | 0.39083040 |
| 76 | AKT2 | 0.38735654 |
| 77 | CAMK1 | 0.38130922 |
| 78 | CAMK2G | 0.37898962 |
| 79 | PTK6 | 0.36359542 |
| 80 | NME2 | 0.36253986 |
| 81 | MAP3K6 | 0.35936153 |
| 82 | SIK1 | 0.35364950 |
| 83 | PRKACA | 0.34638606 |
| 84 | PDK1 | 0.32539020 |
| 85 | TAOK1 | 0.32364334 |
| 86 | PRKACG | 0.32246434 |
| 87 | PTK2B | 0.32174638 |
| 88 | LATS2 | 0.32012851 |
| 89 | TBK1 | 0.29796198 |
| 90 | SGK2 | 0.27716774 |
| 91 | MAPK11 | 0.26584029 |
| 92 | PRKCE | 0.25719228 |
| 93 | PRPF4B | 0.24806819 |
| 94 | RPS6KA1 | 0.23327482 |
| 95 | PRKCH | 0.22399863 |
| 96 | MAPK10 | 0.22027199 |
| 97 | MAP3K11 | 0.20788824 |
| 98 | SGK1 | 0.19940633 |
| 99 | RPS6KB1 | 0.19631249 |
| 100 | PRKG1 | 0.19478653 |
| 101 | MAPK13 | 0.17990294 |
| 102 | JAK1 | 0.17740372 |
| 103 | MAP3K1 | 0.17695236 |
| 104 | ZAP70 | 0.16907576 |
| 105 | MTOR | 0.16838651 |
| 106 | CDK19 | 0.16718490 |
| 107 | RPS6KA3 | 0.16401412 |
| 108 | MAPK7 | 0.16009964 |
| 109 | SGK3 | 0.15285753 |
| 110 | CAMK1G | 0.14620833 |
| 111 | RPS6KB2 | 0.14357248 |
| 112 | CAMK1D | 0.14325410 |
| 113 | MARK2 | 0.13479341 |
| 114 | DAPK2 | 0.13193023 |
| 115 | RPS6KA2 | 0.12337742 |
| 116 | ARAF | 0.11812247 |
| 117 | EEF2K | 0.11740985 |
| 118 | RET | 0.11607920 |
| 119 | MARK3 | 0.11592238 |
| 120 | LATS1 | 0.11508158 |
| 121 | TAOK2 | 0.11248060 |
| 122 | EPHB2 | 0.10775936 |
| 123 | SGK494 | 0.10061718 |
| 124 | SGK223 | 0.10061718 |
| 125 | FGFR4 | 0.09644245 |
| 126 | MAP3K10 | 0.09433127 |
| 127 | JAK2 | 0.09401866 |
| 128 | PAK6 | 0.08807747 |
| 129 | EPHA3 | 0.06969655 |
| 130 | STK11 | 0.06825916 |
| 131 | RAF1 | 0.05553552 |
| 132 | MAPK9 | 0.04664335 |
| 133 | NLK | 0.02753307 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 5.77418026 |
| 2 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 4.26485355 |
| 3 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 4.22751500 |
| 4 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 3.76774903 |
| 5 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 3.71470386 |
| 6 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.31273719 |
| 7 | Propanoate metabolism_Homo sapiens_hsa00640 | 3.30231837 |
| 8 | Parkinsons disease_Homo sapiens_hsa05012 | 3.10194998 |
| 9 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.01176043 |
| 10 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.76037243 |
| 11 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.59408087 |
| 12 | Carbon metabolism_Homo sapiens_hsa01200 | 2.48515980 |
| 13 | Alzheimers disease_Homo sapiens_hsa05010 | 2.36276387 |
| 14 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.31018278 |
| 15 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.22812666 |
| 16 | Fatty acid metabolism_Homo sapiens_hsa01212 | 2.06408638 |
| 17 | Huntingtons disease_Homo sapiens_hsa05016 | 1.86005896 |
| 18 | Viral myocarditis_Homo sapiens_hsa05416 | 1.78995564 |
| 19 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.76672707 |
| 20 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.67554167 |
| 21 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.40507691 |
| 22 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.35713942 |
| 23 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.33320641 |
| 24 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.31221234 |
| 25 | Insulin resistance_Homo sapiens_hsa04931 | 1.26124730 |
| 26 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.21877651 |
| 27 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.16439147 |
| 28 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.14643573 |
| 29 | Insulin signaling pathway_Homo sapiens_hsa04910 | 1.12819306 |
| 30 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.12459762 |
| 31 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.03992221 |
| 32 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.02828959 |
| 33 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.98367450 |
| 34 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.90239855 |
| 35 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.85609988 |
| 36 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.84406577 |
| 37 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.83823822 |
| 38 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.82456572 |
| 39 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.80276692 |
| 40 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.77732158 |
| 41 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.75676965 |
| 42 | Galactose metabolism_Homo sapiens_hsa00052 | 0.75395208 |
| 43 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.74569219 |
| 44 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.73911543 |
| 45 | Lysine degradation_Homo sapiens_hsa00310 | 0.72443193 |
| 46 | Long-term potentiation_Homo sapiens_hsa04720 | 0.70394999 |
| 47 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.69248480 |
| 48 | Focal adhesion_Homo sapiens_hsa04510 | 0.68989705 |
| 49 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.66573961 |
| 50 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.66361025 |
| 51 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.63447024 |
| 52 | Circadian rhythm_Homo sapiens_hsa04710 | 0.61312019 |
| 53 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.61039807 |
| 54 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.57361082 |
| 55 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.52014893 |
| 56 | Tight junction_Homo sapiens_hsa04530 | 0.51587784 |
| 57 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.50530946 |
| 58 | Peroxisome_Homo sapiens_hsa04146 | 0.49258597 |
| 59 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.47804687 |
| 60 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.47164173 |
| 61 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.45610948 |
| 62 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.44495871 |
| 63 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.43941004 |
| 64 | Renin secretion_Homo sapiens_hsa04924 | 0.43665581 |
| 65 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.43104712 |
| 66 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.39428372 |
| 67 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.39174573 |
| 68 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.38419679 |
| 69 | Salivary secretion_Homo sapiens_hsa04970 | 0.36146839 |
| 70 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.34701299 |
| 71 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.34226716 |
| 72 | Histidine metabolism_Homo sapiens_hsa00340 | 0.32118819 |
| 73 | Insulin secretion_Homo sapiens_hsa04911 | 0.32080123 |
| 74 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.29731711 |
| 75 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.29707684 |
| 76 | Amoebiasis_Homo sapiens_hsa05146 | 0.28742880 |
| 77 | Adherens junction_Homo sapiens_hsa04520 | 0.25767452 |
| 78 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.25491659 |
| 79 | Metabolic pathways_Homo sapiens_hsa01100 | 0.24315582 |
| 80 | Sulfur relay system_Homo sapiens_hsa04122 | 0.23957368 |
| 81 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.23163161 |
| 82 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.22695385 |
| 83 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.22434138 |
| 84 | Long-term depression_Homo sapiens_hsa04730 | 0.22062216 |
| 85 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.21865192 |
| 86 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.21496458 |
| 87 | Platelet activation_Homo sapiens_hsa04611 | 0.20889569 |
| 88 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.20085695 |
| 89 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.19317769 |
| 90 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.18398749 |
| 91 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.18287169 |
| 92 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.17338668 |
| 93 | Purine metabolism_Homo sapiens_hsa00230 | 0.17082895 |
| 94 | Melanogenesis_Homo sapiens_hsa04916 | 0.16526364 |
| 95 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.14775045 |
| 96 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.14742022 |
| 97 | Circadian entrainment_Homo sapiens_hsa04713 | 0.12464471 |
| 98 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.11652507 |
| 99 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.11446011 |
| 100 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.09058319 |
| 101 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.08434715 |
| 102 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.08128478 |
| 103 | Glioma_Homo sapiens_hsa05214 | 0.07390196 |
| 104 | Olfactory transduction_Homo sapiens_hsa04740 | 0.06288608 |
| 105 | Gap junction_Homo sapiens_hsa04540 | 0.06195939 |
| 106 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.06059874 |
| 107 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.05974066 |
| 108 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.05968686 |
| 109 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.05435548 |
| 110 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.04831268 |
| 111 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.04715416 |
| 112 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.03744647 |
| 113 | Bile secretion_Homo sapiens_hsa04976 | 0.01378176 |
| 114 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.00894273 |
| 115 | ABC transporters_Homo sapiens_hsa02010 | 0.00811290 |
| 116 | Acute myeloid leukemia_Homo sapiens_hsa05221 | -0.0381855 |
| 117 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | -0.0367362 |
| 118 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | -0.0261617 |

