ASB12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-mediated cell contraction (GO:0070252)9.87815925
2regulation of skeletal muscle contraction (GO:0014819)9.19877930
3sarcomere organization (GO:0045214)8.52700352
4myofibril assembly (GO:0030239)7.82774171
5sarcoplasmic reticulum calcium ion transport (GO:0070296)7.60159878
6protein targeting to Golgi (GO:0000042)7.54977429
7actin filament-based movement (GO:0030048)7.33495286
8cardiac myofibril assembly (GO:0055003)7.25959499
9establishment of protein localization to Golgi (GO:0072600)7.16550711
10skeletal muscle contraction (GO:0003009)7.14461445
11retrograde transport, vesicle recycling within Golgi (GO:0000301)7.12147653
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.78896354
13striated muscle contraction (GO:0006941)6.68093207
14heart contraction (GO:0060047)6.34985647
15heart process (GO:0003015)6.34985647
16negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.33407822
17cardiac muscle contraction (GO:0060048)6.30071493
18sperm motility (GO:0030317)6.23388155
19regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.09603467
20skeletal muscle adaptation (GO:0043501)5.98071799
21actomyosin structure organization (GO:0031032)5.90371278
22plasma membrane repair (GO:0001778)5.89484211
23cardiac muscle cell development (GO:0055013)5.79377932
24regulation of relaxation of muscle (GO:1901077)5.64022951
25carnitine shuttle (GO:0006853)5.60708673
26response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.60199115
27acrosome reaction (GO:0007340)5.59169311
28cardiac cell development (GO:0055006)5.45500735
29protein localization to Golgi apparatus (GO:0034067)5.45103358
30cardiac muscle tissue morphogenesis (GO:0055008)5.44129448
31tricarboxylic acid cycle (GO:0006099)5.40479380
32regulation of cell communication by electrical coupling (GO:0010649)5.40382207
33negative regulation of potassium ion transmembrane transport (GO:1901380)5.37629720
34regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.13561412
35protein polyglutamylation (GO:0018095)5.10407599
36muscle tissue morphogenesis (GO:0060415)5.05684280
37regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.98850114
38muscle contraction (GO:0006936)4.74311466
39regulation of actin filament-based movement (GO:1903115)4.73508653
40fatty acid transmembrane transport (GO:1902001)4.70520990
41response to inactivity (GO:0014854)4.61340562
42cardiac muscle hypertrophy (GO:0003300)4.60041239
43cytidine metabolic process (GO:0046087)4.53220496
44cytidine catabolic process (GO:0006216)4.53220496
45cytidine deamination (GO:0009972)4.53220496
46striated muscle hypertrophy (GO:0014897)4.52131687
47pyrimidine ribonucleoside catabolic process (GO:0046133)4.51674878
48regulation of acyl-CoA biosynthetic process (GO:0050812)4.50961591
49oxidative phosphorylation (GO:0006119)4.46842765
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.35069486
51fusion of sperm to egg plasma membrane (GO:0007342)4.34956019
52carnitine transmembrane transport (GO:1902603)4.33599622
53glycogen catabolic process (GO:0005980)4.33162189
54regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.30713178
55microtubule polymerization or depolymerization (GO:0031109)4.30429195
56muscle system process (GO:0003012)4.28163833
57seminiferous tubule development (GO:0072520)4.26867933
58chromosome condensation (GO:0030261)4.24142881
59regulation of striated muscle contraction (GO:0006942)4.21935299
60striated muscle adaptation (GO:0014888)4.20790886
61creatine metabolic process (GO:0006600)4.17495093
62myoblast fusion (GO:0007520)4.16152337
63regulation of cofactor metabolic process (GO:0051193)4.15277274
64regulation of coenzyme metabolic process (GO:0051196)4.15277274
65response to muscle activity (GO:0014850)4.13609537
66striated muscle cell development (GO:0055002)4.12295108
67skeletal muscle fiber development (GO:0048741)4.11671092
68ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.11474316
69adult heart development (GO:0007512)4.06891577
70skeletal muscle tissue regeneration (GO:0043403)4.06578117
71glucan catabolic process (GO:0009251)4.03292232
72DNA packaging (GO:0006323)4.00788177
73muscle fiber development (GO:0048747)4.00728668
74amino-acid betaine transport (GO:0015838)4.00648627
75carnitine transport (GO:0015879)4.00648627
76ATP synthesis coupled proton transport (GO:0015986)3.99185229
77energy coupled proton transport, down electrochemical gradient (GO:0015985)3.99185229
78sperm capacitation (GO:0048240)3.97692167
79respiratory electron transport chain (GO:0022904)3.97333574
80muscle hypertrophy (GO:0014896)3.96617577
81striated muscle atrophy (GO:0014891)3.94781436
82centriole replication (GO:0007099)3.93466307
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.89080200
84electron transport chain (GO:0022900)3.87212331
85microtubule depolymerization (GO:0007019)3.83694001
86rRNA methylation (GO:0031167)3.83103511
87cellular polysaccharide catabolic process (GO:0044247)3.81786749
88negative regulation of skeletal muscle tissue development (GO:0048642)3.80372866
89regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.78555854
90skeletal muscle tissue development (GO:0007519)3.78552418
91glucan biosynthetic process (GO:0009250)3.76389996
92glycogen biosynthetic process (GO:0005978)3.76389996
93centriole assembly (GO:0098534)3.71495905
94regulation of sarcomere organization (GO:0060297)3.69045884
95positive regulation of myotube differentiation (GO:0010831)3.67655860
96negative regulation of protein localization to cell surface (GO:2000009)3.67129159
97spermatogenesis (GO:0007283)3.65488066
98male gamete generation (GO:0048232)3.64300159
99polysaccharide catabolic process (GO:0000272)3.60685160
100syncytium formation by plasma membrane fusion (GO:0000768)3.60199272
101muscle organ morphogenesis (GO:0048644)3.59492484
102RNA destabilization (GO:0050779)3.59374577
103regulation of centriole replication (GO:0046599)3.57962703
104glomerular visceral epithelial cell development (GO:0072015)3.57139298
105ventricular cardiac muscle cell action potential (GO:0086005)3.56938455
106microtubule nucleation (GO:0007020)3.54223893
107regulation of membrane repolarization (GO:0060306)3.54168309
108regulation of ATPase activity (GO:0043462)3.54119923
109regulation of ATP catabolic process (GO:1903289)3.54119923
110NADH metabolic process (GO:0006734)3.52025819
111muscle cell development (GO:0055001)3.50058408
112heart trabecula formation (GO:0060347)3.46633075
113purine nucleotide salvage (GO:0032261)3.44627964
114myotube cell development (GO:0014904)3.44451359
115response to activity (GO:0014823)3.43209675
116neuromuscular synaptic transmission (GO:0007274)3.42407094
117negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.42217248
118fructose metabolic process (GO:0006000)3.42180318
119muscle adaptation (GO:0043500)3.35993702
120glycolytic process (GO:0006096)3.35147032
121gamete generation (GO:0007276)3.34816684
122muscle cell fate commitment (GO:0042693)3.34621454
123muscle atrophy (GO:0014889)3.31927859
124calcium ion-dependent exocytosis (GO:0017156)3.31851371
125cardiac muscle adaptation (GO:0014887)3.31446253
126cardiac muscle hypertrophy in response to stress (GO:0014898)3.31446253
127muscle hypertrophy in response to stress (GO:0003299)3.31446253
128musculoskeletal movement (GO:0050881)3.30092484
129multicellular organismal movement (GO:0050879)3.30092484
130regulation of sulfur metabolic process (GO:0042762)3.29598101
131regulation of muscle contraction (GO:0006937)3.28054022
132nuclear pore complex assembly (GO:0051292)3.27733145
133gluconeogenesis (GO:0006094)3.26953279
134plasma membrane fusion (GO:0045026)3.26668562
135muscle structure development (GO:0061061)3.25939620
136negative regulation of striated muscle cell apoptotic process (GO:0010664)3.25706712
137muscle organ development (GO:0007517)3.25506453
138regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.25359505
139quinone biosynthetic process (GO:1901663)3.23720457
140ubiquinone biosynthetic process (GO:0006744)3.23720457
141glycogen metabolic process (GO:0005977)3.23410773
142negative regulation of inclusion body assembly (GO:0090084)3.22920183
143glomerular epithelial cell development (GO:0072310)3.21660318
144spermatid development (GO:0007286)3.20181435
145cellular glucan metabolic process (GO:0006073)3.16606013
146glucan metabolic process (GO:0044042)3.16606013
147spermatid nucleus differentiation (GO:0007289)3.14875903
148intra-Golgi vesicle-mediated transport (GO:0006891)3.13194890
149neuronal action potential propagation (GO:0019227)3.09685416
150muscle filament sliding (GO:0030049)11.7976053
151actin-myosin filament sliding (GO:0033275)11.7976053

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.64050909
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.40300247
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.13410916
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.86350558
5EP300_21415370_ChIP-Seq_HL-1_Mouse4.69731827
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.99861985
7ESR1_20079471_ChIP-ChIP_T-47D_Human3.97595986
8MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.66487972
9TBX20_22328084_ChIP-Seq_HEART_Mouse3.54149377
10TBX20_22080862_ChIP-Seq_HEART_Mouse3.54149377
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.43432971
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.04132646
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.96027790
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.65514763
15GATA4_21415370_ChIP-Seq_HL-1_Mouse2.58882717
16BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.45067855
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34628277
18FUS_26573619_Chip-Seq_HEK293_Human2.32437815
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30837824
20ZNF274_21170338_ChIP-Seq_K562_Hela2.25672403
21EZH2_22144423_ChIP-Seq_EOC_Human2.19291431
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.14464113
23VDR_22108803_ChIP-Seq_LS180_Human2.01906320
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.01551813
25DROSHA_22980978_ChIP-Seq_HELA_Human1.90381060
26PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.88438848
27NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.87157204
28ZNF263_19887448_ChIP-Seq_K562_Human1.80213692
29POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.79024257
30TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79024257
31GBX2_23144817_ChIP-Seq_PC3_Human1.69571850
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.66300459
33ER_23166858_ChIP-Seq_MCF-7_Human1.63012739
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61928620
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57604447
36ISL1_27105846_Chip-Seq_CPCs_Mouse1.57007763
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53900462
38AR_21572438_ChIP-Seq_LNCaP_Human1.53652408
39CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.53463787
40CBX2_22325352_ChIP-Seq_293T-Rex_Human1.50589176
41GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.47128149
42HNFA_21074721_ChIP-Seq_CACO-2_Human1.44606113
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.43034313
44AUTS2_25519132_ChIP-Seq_293T-REX_Human1.41522324
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40889098
46RBPJ_21746931_ChIP-Seq_IB4_Human1.40648994
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.40249578
48PHF8_20622853_ChIP-Seq_HELA_Human1.39444309
49ETV1_20927104_ChIP-Seq_GIST48_Human1.39245410
50P53_22127205_ChIP-Seq_FIBROBLAST_Human1.34081288
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34052865
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.33418661
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33078938
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29320490
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28141090
56TDRD3_21172665_ChIP-Seq_MCF-7_Human1.26452314
57P300_19829295_ChIP-Seq_ESCs_Human1.25895944
58SMAD4_21799915_ChIP-Seq_A2780_Human1.25024546
59OCT4_20526341_ChIP-Seq_ESCs_Human1.24486118
60PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.23626767
61NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22366578
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22038987
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.19392725
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19210604
65SPI1_20517297_ChIP-Seq_HL60_Human1.18830720
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18584596
67CEBPB_22108803_ChIP-Seq_LS180_Human1.18079973
68AR_25329375_ChIP-Seq_VCAP_Human1.16138503
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.15023590
70CTCF_27219007_Chip-Seq_Bcells_Human1.14922930
71* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14675702
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10748113
73FOXH1_21741376_ChIP-Seq_ESCs_Human1.09415039
74NFYA_21822215_ChIP-Seq_K562_Human1.09205862
75TAF15_26573619_Chip-Seq_HEK293_Human1.08380004
76ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07883329
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.07673582
78TAF2_19829295_ChIP-Seq_ESCs_Human1.06817817
79SMAD4_21741376_ChIP-Seq_HESCs_Human1.06794056
80SOX2_22085726_ChIP-Seq_NPCs_Mouse1.06043505
81MYC_19829295_ChIP-Seq_ESCs_Human1.03615097
82STAT3_23295773_ChIP-Seq_U87_Human1.02999020
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01547681
84SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01201730
85KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.00898978
86NANOG_20526341_ChIP-Seq_ESCs_Human1.00247423
87MYC_27129775_Chip-Seq_CORNEA_Mouse0.99811038
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99719076
89KDM2B_26808549_Chip-Seq_REH_Human0.99649311
90SALL4_22934838_ChIP-ChIP_CD34+_Human0.99155859
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98831794
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97432303
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96588294
94SOX2_21211035_ChIP-Seq_LN229_Gbm0.96385333
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96296911
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96078501
97ARNT_22903824_ChIP-Seq_MCF-7_Human0.95945870
98CBX2_27304074_Chip-Seq_ESCs_Mouse0.95595404
99CJUN_26792858_Chip-Seq_BT549_Human0.94940251
100SA1_27219007_Chip-Seq_Bcells_Human0.94424918
101EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93382481
102GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.92776618
103CTCF_21964334_ChIP-Seq_BJAB-B_Human0.92582694
104LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.92434013
105FLI1_27457419_Chip-Seq_LIVER_Mouse0.92412263
106NFE2_27457419_Chip-Seq_LIVER_Mouse0.92221600
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.91814047
108EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90734998
109TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.90242654
110CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90192193
111NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88937510
112STAT1_20625510_ChIP-Seq_HELA_Human0.88868681
113TP63_22573176_ChIP-Seq_HFKS_Human0.88828423
114YY1_22570637_ChIP-Seq_MALME-3M_Human0.88554738
115RAC3_21632823_ChIP-Seq_H3396_Human0.85711016
116WDR5_24793694_ChIP-Seq_LNCAP_Human0.83527546
117TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83403050
118CBP_21632823_ChIP-Seq_H3396_Human0.82687489
119* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80414848
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80180084
121SMAD4_21741376_ChIP-Seq_EPCs_Human0.79433787
122BCAT_22108803_ChIP-Seq_LS180_Human0.77386187
123ERG_20517297_ChIP-Seq_VCAP_Human0.76945664
124GF1_26923725_Chip-Seq_HPCs_Mouse0.75141315
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.74102470
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.73506887
127TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.73075978
128GATA1_22025678_ChIP-Seq_K562_Human0.73024935
129ERA_21632823_ChIP-Seq_H3396_Human0.71028560
130SMC1_22415368_ChIP-Seq_MEFs_Mouse0.70926454
131HTT_18923047_ChIP-ChIP_STHdh_Human0.70143930
132E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.69781875
133NFIB_24661679_ChIP-Seq_LUNG_Mouse0.69528831
134E2F1_20622854_ChIP-Seq_HELA_Human0.69264276
135STAT1_17558387_ChIP-Seq_HELA_Human0.69051176
136ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.67774525
137GATA6_21074721_ChIP-Seq_CACO-2_Human0.67602276
138P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.67265243
139RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.67209868
140TBL1_22424771_ChIP-Seq_293T_Human0.66684579
141CBP_20019798_ChIP-Seq_JUKART_Human0.66461806
142IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.66461806
143GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.66010416
144PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.65319663
145OCT1_27270436_Chip-Seq_PROSTATE_Human0.65173662
146KLF5_20875108_ChIP-Seq_MESCs_Mouse0.64906573
147LXR_22158963_ChIP-Seq_LIVER_Mouse0.64672513
148FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.64192225
149CLOCK_20551151_ChIP-Seq_293T_Human0.64064807
150GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.63990380
151GATA3_21878914_ChIP-Seq_MCF-7_Human0.63885038
152CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.63859898
153HOXB7_26014856_ChIP-Seq_BT474_Human0.63857755
154CSB_26484114_Chip-Seq_FIBROBLAST_Human0.63485171
155SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.62645423
156NANOG_19829295_ChIP-Seq_ESCs_Human0.62613015
157SOX2_19829295_ChIP-Seq_ESCs_Human0.62613015
158NFYB_21822215_ChIP-Seq_K562_Human0.62129553
159GF1B_26923725_Chip-Seq_HPCs_Mouse0.61639236

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.44177857
2MP0004145_abnormal_muscle_electrophysio6.03844943
3MP0000749_muscle_degeneration5.96308480
4MP0000751_myopathy5.02625701
5MP0002837_dystrophic_cardiac_calcinosis4.61344629
6MP0004036_abnormal_muscle_relaxation4.59435827
7MP0004084_abnormal_cardiac_muscle4.15374705
8MP0002106_abnormal_muscle_physiology3.55806383
9MP0004087_abnormal_muscle_fiber3.52099142
10MP0000747_muscle_weakness3.26592662
11MP0002269_muscular_atrophy3.23270999
12MP0005620_abnormal_muscle_contractility3.20697178
13MP0004215_abnormal_myocardial_fiber3.03003243
14MP0000759_abnormal_skeletal_muscle2.99841280
15MP0005330_cardiomyopathy2.98309758
16MP0005369_muscle_phenotype2.87995020
17MP0000750_abnormal_muscle_regeneration2.67761996
18MP0004130_abnormal_muscle_cell2.63923787
19MP0002972_abnormal_cardiac_muscle2.56699857
20MP0004233_abnormal_muscle_weight2.56056424
21MP0006036_abnormal_mitochondrial_physio2.22676786
22MP0010630_abnormal_cardiac_muscle2.14985782
23MP0004484_altered_response_of2.04556589
24MP0003221_abnormal_cardiomyocyte_apopto2.04455948
25MP0003878_abnormal_ear_physiology2.01855254
26MP0005377_hearing/vestibular/ear_phenot2.01855254
27MP0001544_abnormal_cardiovascular_syste1.92619431
28MP0005385_cardiovascular_system_phenoty1.92619431
29MP0008775_abnormal_heart_ventricle1.88412228
30MP0002332_abnormal_exercise_endurance1.88299944
31MP0005451_abnormal_body_composition1.83479709
32MP0003137_abnormal_impulse_conducting1.81003191
33MP0006138_congestive_heart_failure1.74936194
34MP0003828_pulmonary_edema1.56305921
35MP0002822_catalepsy1.49699388
36MP0004510_myositis1.49618602
37MP0003950_abnormal_plasma_membrane1.48919302
38MP0002127_abnormal_cardiovascular_syste1.47336210
39MP0003879_abnormal_hair_cell1.46915849
40MP0004085_abnormal_heartbeat1.34960687
41MP0000733_abnormal_muscle_development1.33526564
42MP0003698_abnormal_male_reproductive1.26839550
43MP0002108_abnormal_muscle_morphology1.21972615
44MP0005666_abnormal_adipose_tissue1.18566990
45MP0006035_abnormal_mitochondrial_morpho1.13139569
46MP0004185_abnormal_adipocyte_glucose1.12291922
47MP0003567_abnormal_fetal_cardiomyocyte1.10719781
48MP0003806_abnormal_nucleotide_metabolis1.09163485
49MP0001929_abnormal_gametogenesis1.08469045
50MP0005266_abnormal_metabolism1.01100326
51MP0000266_abnormal_heart_morphology0.99675702
52MP0005670_abnormal_white_adipose0.95348993
53MP0003122_maternal_imprinting0.90825413
54MP0001485_abnormal_pinna_reflex0.90817845
55MP0001486_abnormal_startle_reflex0.90409504
56MP0005167_abnormal_blood-brain_barrier0.87446779
57MP0002971_abnormal_brown_adipose0.83431877
58MP0002234_abnormal_pharynx_morphology0.80915404
59MP0000003_abnormal_adipose_tissue0.79896972
60MP0003123_paternal_imprinting0.77959035
61MP0000343_altered_response_to0.75334615
62MP0001984_abnormal_olfaction0.75266880
63MP0005423_abnormal_somatic_nervous0.71742520
64MP0001346_abnormal_lacrimal_gland0.70728836
65MP0005375_adipose_tissue_phenotype0.66514943
66MP0005410_abnormal_fertilization0.64450426
67MP0006276_abnormal_autonomic_nervous0.63329429
68MP0001348_abnormal_lacrimal_gland0.62515371
69MP0009780_abnormal_chondrocyte_physiolo0.60710930
70MP0000230_abnormal_systemic_arterial0.60587058
71MP0005535_abnormal_body_temperature0.58434253
72MP0002067_abnormal_sensory_capabilities0.56482073
73MP0002161_abnormal_fertility/fecundity0.54491543
74MP0004043_abnormal_pH_regulation0.54090468
75MP0005332_abnormal_amino_acid0.53858134
76MP0009250_abnormal_appendicular_skeleto0.53130095
77MP0002128_abnormal_blood_circulation0.52939331
78MP0003705_abnormal_hypodermis_morpholog0.52300133
79MP0009115_abnormal_fat_cell0.51545475
80MP0008995_early_reproductive_senescence0.50848054
81MP0005253_abnormal_eye_physiology0.50811078
82MP0003121_genomic_imprinting0.50683921
83MP0000762_abnormal_tongue_morphology0.49775256
84MP0001529_abnormal_vocalization0.49374404
85MP0005645_abnormal_hypothalamus_physiol0.48762748
86MP0001440_abnormal_grooming_behavior0.48401749
87MP0002734_abnormal_mechanical_nocicepti0.48118024
88MP0008569_lethality_at_weaning0.47740654
89MP0001963_abnormal_hearing_physiology0.44819274
90MP0003011_delayed_dark_adaptation0.43203691
91MP0000372_irregular_coat_pigmentation0.42120302
92MP0001765_abnormal_ion_homeostasis0.41964858
93MP0002210_abnormal_sex_determination0.39862280
94MP0002925_abnormal_cardiovascular_devel0.39630244
95MP0002088_abnormal_embryonic_growth/wei0.39393178
96MP0002078_abnormal_glucose_homeostasis0.39259586
97MP0003566_abnormal_cell_adhesion0.39250516
98MP0003948_abnormal_gas_homeostasis0.38934139
99MP0005165_increased_susceptibility_to0.38444624
100MP0003984_embryonic_growth_retardation0.38442610
101MP0000026_abnormal_inner_ear0.38060332
102MP0009672_abnormal_birth_weight0.37653191
103MP0004134_abnormal_chest_morphology0.36351271
104MP0001661_extended_life_span0.35412363
105MP0004142_abnormal_muscle_tone0.35217926
106MP0003385_abnormal_body_wall0.35160766
107MP0003045_fibrosis0.34344371
108MP0002229_neurodegeneration0.32690686
109MP0005379_endocrine/exocrine_gland_phen0.32634627
110MP0002876_abnormal_thyroid_physiology0.31978607
111MP0010368_abnormal_lymphatic_system0.31351669
112MP0009697_abnormal_copulation0.31272909
113MP0005452_abnormal_adipose_tissue0.31192832
114MP0004147_increased_porphyrin_level0.30910185
115MP0005319_abnormal_enzyme/_coenzyme0.30839007
116MP0009384_cardiac_valve_regurgitation0.30604772
117MP0001727_abnormal_embryo_implantation0.30395566
118MP0003656_abnormal_erythrocyte_physiolo0.29790960
119MP0002066_abnormal_motor_capabilities/c0.29610286
120MP0003959_abnormal_lean_body0.29577150
121MP0004270_analgesia0.29382028
122MP0001784_abnormal_fluid_regulation0.29167427
123MP0001614_abnormal_blood_vessel0.28727744
124MP0002249_abnormal_larynx_morphology0.27553026
125MP0005083_abnormal_biliary_tract0.27154795
126MP0001730_embryonic_growth_arrest0.26758391
127MP0005334_abnormal_fat_pad0.26226821
128MP0004272_abnormal_basement_membrane0.25673892
129MP0000013_abnormal_adipose_tissue0.25128019
130MP0000767_abnormal_smooth_muscle0.24943267
131MP0005584_abnormal_enzyme/coenzyme_acti0.23145116
132MP0002114_abnormal_axial_skeleton0.22073715
133MP0008877_abnormal_DNA_methylation0.21875564
134MP0003279_aneurysm0.21858428
135MP0005380_embryogenesis_phenotype0.21370529
136MP0001672_abnormal_embryogenesis/_devel0.21370529
137MP0005376_homeostasis/metabolism_phenot0.21105262
138MP0001299_abnormal_eye_distance/0.20400336
139MP0003941_abnormal_skin_development0.19369401
140MP0000537_abnormal_urethra_morphology0.19242573
141MP0001697_abnormal_embryo_size0.18723050
142MP0004197_abnormal_fetal_growth/weight/0.17555187

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)8.84300122
2Exercise-induced myalgia (HP:0003738)8.78349202
3Muscle fiber inclusion bodies (HP:0100299)7.55927665
4Muscle hypertrophy of the lower extremities (HP:0008968)7.38438969
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.31018452
6Calf muscle hypertrophy (HP:0008981)7.12529437
7Nemaline bodies (HP:0003798)6.77010408
8Myoglobinuria (HP:0002913)5.90093660
9Type 1 muscle fiber predominance (HP:0003803)5.89565476
10Hyporeflexia of lower limbs (HP:0002600)5.30888793
11Muscle fiber splitting (HP:0003555)5.29159173
12Sudden death (HP:0001699)5.14692574
13Rhabdomyolysis (HP:0003201)5.04615029
14Distal arthrogryposis (HP:0005684)5.01721790
15Abnormality of the calf musculature (HP:0001430)4.99777082
16EMG: myopathic abnormalities (HP:0003458)4.80559500
17Abnormality of the left ventricular outflow tract (HP:0011103)4.79392176
18Subaortic stenosis (HP:0001682)4.79392176
19Myopathic facies (HP:0002058)4.61312422
20Difficulty running (HP:0009046)4.49875685
21Ventricular tachycardia (HP:0004756)4.27900227
22Muscle stiffness (HP:0003552)4.27035093
23Round ear (HP:0100830)4.20195230
24Ulnar deviation of the wrist (HP:0003049)4.05519604
25Myotonia (HP:0002486)3.77889942
26Asymmetric septal hypertrophy (HP:0001670)3.67215756
27Lipoatrophy (HP:0100578)3.64926299
28Increased connective tissue (HP:0009025)3.60003121
29Neck muscle weakness (HP:0000467)3.50789095
30Calcaneovalgus deformity (HP:0001848)3.46669249
31Absent phalangeal crease (HP:0006109)3.34044723
32Atrial fibrillation (HP:0005110)3.33486118
33Rimmed vacuoles (HP:0003805)3.24685587
34Areflexia of lower limbs (HP:0002522)3.24252642
35Deformed tarsal bones (HP:0008119)3.08766587
36Primary atrial arrhythmia (HP:0001692)3.08502427
37Dilated cardiomyopathy (HP:0001644)3.05670429
38Abnormality of skeletal muscle fiber size (HP:0012084)2.98820287
39Supraventricular tachycardia (HP:0004755)2.96717561
40Supraventricular arrhythmia (HP:0005115)2.88922709
41Difficulty climbing stairs (HP:0003551)2.85775489
42Distal lower limb muscle weakness (HP:0009053)2.85501105
43Abnormal finger flexion creases (HP:0006143)2.77294305
44Increased variability in muscle fiber diameter (HP:0003557)2.75613489
45Bundle branch block (HP:0011710)2.75200693
46EMG: neuropathic changes (HP:0003445)2.70564166
47Fetal akinesia sequence (HP:0001989)2.67967504
48Right ventricular cardiomyopathy (HP:0011663)2.59338295
49Acute necrotizing encephalopathy (HP:0006965)2.58224048
50Ventricular arrhythmia (HP:0004308)2.54038411
51Abnormal mitochondria in muscle tissue (HP:0008316)2.53797134
52Palpitations (HP:0001962)2.53277389
53Chronic hepatic failure (HP:0100626)2.50011164
54Exercise intolerance (HP:0003546)2.47726970
55Hypoalphalipoproteinemia (HP:0003233)2.46221436
56Insulin-resistant diabetes mellitus (HP:0000831)2.45967424
57Tubulointerstitial nephritis (HP:0001970)2.44346667
58Generalized muscle weakness (HP:0003324)2.42876734
59Prolonged QT interval (HP:0001657)2.42057962
60Syncope (HP:0001279)2.41797366
61Centrally nucleated skeletal muscle fibers (HP:0003687)2.41251645
62Heart block (HP:0012722)2.36517063
63Malignant hyperthermia (HP:0002047)2.34498724
64Distal lower limb amyotrophy (HP:0008944)2.29084499
65Frequent falls (HP:0002359)2.27283593
66Muscular dystrophy (HP:0003560)2.23244002
67Abnormal atrioventricular conduction (HP:0005150)2.19920218
68Abnormality of the neuromuscular junction (HP:0003398)2.18048842
69Fatigable weakness (HP:0003473)2.18048842
70Acute encephalopathy (HP:0006846)2.15301362
71Left ventricular hypertrophy (HP:0001712)2.14730302
72Mildly elevated creatine phosphokinase (HP:0008180)2.13810370
73Hepatic necrosis (HP:0002605)2.12855090
74Progressive macrocephaly (HP:0004481)2.08554855
75Cone-rod dystrophy (HP:0000548)2.07553538
76Gowers sign (HP:0003391)2.06285420
77Abnormality of the hip-girdle musculature (HP:0001445)2.03253658
78Abnormality of the musculature of the pelvis (HP:0001469)2.03253658
79Proximal amyotrophy (HP:0007126)2.02450139
80Pelvic girdle muscle weakness (HP:0003749)2.00490247
81Mitochondrial inheritance (HP:0001427)2.00222854
82Shoulder girdle muscle weakness (HP:0003547)1.99944083
83Increased purine levels (HP:0004368)1.99829797
84Hyperuricemia (HP:0002149)1.99829797
85Type 2 muscle fiber atrophy (HP:0003554)1.99202398
86Hyperkalemia (HP:0002153)1.96798869
87Hepatocellular necrosis (HP:0001404)1.93914956
88Abnormality of the calcaneus (HP:0008364)1.93577745
89Hypoplastic ischia (HP:0003175)1.93109583
90Waddling gait (HP:0002515)1.91086343
91Limb-girdle muscle weakness (HP:0003325)1.90722978
92Hip contracture (HP:0003273)1.89804013
93Limb-girdle muscle atrophy (HP:0003797)1.87910869
94Muscle fiber atrophy (HP:0100295)1.87834845
95Weak cry (HP:0001612)1.87753803
96Increased CSF lactate (HP:0002490)1.86451262
97Atrioventricular block (HP:0001678)1.85954747
98Facial diplegia (HP:0001349)1.85100349
99Progressive muscle weakness (HP:0003323)1.83249291
100Paralysis (HP:0003470)1.83000967
101Nonprogressive disorder (HP:0003680)1.82040509
102Abnormality of the shoulder girdle musculature (HP:0001435)1.81651505
103Slender build (HP:0001533)1.81285578
104Bulbar palsy (HP:0001283)1.80439527
105Abnormality of potassium homeostasis (HP:0011042)1.78798708
106Increased serum pyruvate (HP:0003542)1.78709664
107Abnormality of glycolysis (HP:0004366)1.78709664
108Scapular winging (HP:0003691)1.77874537
109Double outlet right ventricle (HP:0001719)1.76789916
110Congenital malformation of the right heart (HP:0011723)1.76789916
111Abnormal EKG (HP:0003115)1.76496580
112Cerebral edema (HP:0002181)1.74295412
113Abnormality of the foot musculature (HP:0001436)1.72352607
114Popliteal pterygium (HP:0009756)1.72019320
115Palmoplantar keratoderma (HP:0000982)1.71135231
116Spinal rigidity (HP:0003306)1.70574719
117Long clavicles (HP:0000890)1.67634641
118Lower limb amyotrophy (HP:0007210)1.66602783
119Truncal obesity (HP:0001956)1.65566982
120Menstrual irregularities (HP:0000858)1.64730963
121Respiratory insufficiency due to muscle weakness (HP:0002747)1.60880712
122Amelogenesis imperfecta (HP:0000705)1.55082834
123Metatarsus adductus (HP:0001840)1.51042651
124Ulnar deviation of finger (HP:0009465)1.50138657
125Dynein arm defect of respiratory motile cilia (HP:0012255)1.49401909
126Absent/shortened dynein arms (HP:0200106)1.49401909
127Narrow face (HP:0000275)1.43642787
128Resting tremor (HP:0002322)1.42102099

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN8.84650831
2TTN5.29667485
3PHKG14.43790021
4PHKG24.43790021
5MUSK2.98330457
6PDK42.92300369
7PDK32.92300369
8MYLK2.65849847
9STK242.60307588
10BRD42.52499944
11NME12.50813285
12PIK3CA2.46666056
13NEK12.21770122
14DMPK2.14894857
15PIK3CG2.06672880
16BCKDK1.95302712
17PNCK1.94120283
18MAP2K31.89054354
19PINK11.88857573
20PLK21.77234806
21PDK21.73367387
22STK38L1.72181226
23PKN21.67857683
24ZAK1.65989999
25TRIB31.48213521
26MARK11.43305770
27MAP3K71.36888632
28TRPM71.28853006
29CAMK1G1.25824304
30MAPK121.23643292
31DYRK1B1.23043322
32MAP4K21.13763956
33ILK1.13090508
34TYRO31.07394014
35LIMK11.04401540
36MAP2K41.04131551
37PRKAA21.03954212
38PRKAA10.93150537
39MAPKAPK30.92991240
40EPHA40.78484028
41LMTK20.77976785
42PRKD30.77973381
43MAP2K60.76995905
44NEK90.73186620
45MAP3K30.72387522
46PLK40.71796632
47LATS20.70674373
48TIE10.66947759
49ROCK10.64633663
50CDC42BPA0.64062321
51TESK10.59083942
52AKT30.58042857
53MAPK130.56326180
54MAP3K60.55182810
55STK30.53890690
56PAK30.53384073
57MOS0.53052745
58MAP3K50.52277915
59LATS10.47920588
60NEK60.47676514
61CAMK2D0.46850127
62AKT20.45465568
63CAMK2G0.44952885
64RIPK10.43707576
65MAPK110.42265064
66PRKD10.41617532
67PKN10.41482640
68SGK20.41066193
69FLT30.41031832
70EEF2K0.40941844
71MAPK70.40598628
72KSR20.39301888
73BRAF0.38868319
74TAOK10.38702307
75MAPK150.37970628
76SGK30.36476967
77PRKACB0.36341721
78PTK2B0.35125263
79SGK2230.34983439
80SGK4940.34983439
81STK40.34578047
82MAPK40.32867905
83STK380.31711233
84CAMK2B0.30796154
85PRKG10.28283140
86PRKACA0.27832857
87MAP2K20.27049969
88CAMK2A0.26925339
89TTK0.26584793
90RAF10.26223011
91DAPK30.25689598
92MAP3K130.23870885
93ICK0.22729067
94WNK40.22333967
95MAPK100.21929183
96MARK20.21581728
97BMPR1B0.21293837
98ROCK20.21204112
99WNK30.19311610
100SIK20.19066375
101ERBB40.18844157
102CCNB10.18768182
103CDK190.17930467
104CAMK10.17773138
105SGK10.17345321
106INSRR0.16835852
107CAMK1D0.16303517
108MAP3K110.16291897
109NTRK30.16285513
110PRKG20.15651608
111PDK10.15573112
112RPS6KA30.15562659
113FGFR20.14412029
114DAPK20.14222590
115GSK3B0.13738760
116MAP3K10.12547726
117RPS6KA10.12222631
118MARK30.11494173
119FGFR10.11481766
120CDK30.10798719
121RPS6KA20.10651200
122STK390.10284125
123PRKACG0.09215386
124PAK20.08969443
125MAPK80.08919235
126CDK10.08765959
127MAPK10.07921958
128PDPK10.07441453
129PAK60.06706044
130ERBB30.06355343
131CDK40.05969128
132WNK10.05551612
133MAP2K10.05096054
134PRKCQ0.04763379
135GRK70.04728915
136MAP3K100.04511098
137MAP3K80.02368247
138KSR10.01841856
139CAMK40.01754217
140EPHB20.01178995
141TAOK20.00926117

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.19849831
2Cardiac muscle contraction_Homo sapiens_hsa042605.14733199
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.16828568
4Dilated cardiomyopathy_Homo sapiens_hsa054143.64860815
5Parkinsons disease_Homo sapiens_hsa050123.46546645
6Oxidative phosphorylation_Homo sapiens_hsa001903.28903378
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.25918235
8Propanoate metabolism_Homo sapiens_hsa006403.01000224
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.79543220
10Carbon metabolism_Homo sapiens_hsa012002.63008711
11Alzheimers disease_Homo sapiens_hsa050102.57515479
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.49922743
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.35179322
14Huntingtons disease_Homo sapiens_hsa050162.32574119
15Pyruvate metabolism_Homo sapiens_hsa006202.07700589
16Glucagon signaling pathway_Homo sapiens_hsa049221.89792066
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.82717328
18Fatty acid degradation_Homo sapiens_hsa000711.80100728
19Starch and sucrose metabolism_Homo sapiens_hsa005001.76659254
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.75901648
21Biosynthesis of amino acids_Homo sapiens_hsa012301.75807775
22Olfactory transduction_Homo sapiens_hsa047401.61664601
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49900543
24Nitrogen metabolism_Homo sapiens_hsa009101.42626387
25Fatty acid metabolism_Homo sapiens_hsa012121.40189623
26Circadian rhythm_Homo sapiens_hsa047101.40045578
27Galactose metabolism_Homo sapiens_hsa000521.33837129
28Fructose and mannose metabolism_Homo sapiens_hsa000511.29100404
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28623022
30Oxytocin signaling pathway_Homo sapiens_hsa049211.28034502
31Insulin resistance_Homo sapiens_hsa049311.27907145
32Insulin signaling pathway_Homo sapiens_hsa049101.27518785
33Viral myocarditis_Homo sapiens_hsa054161.21963957
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15756937
35Long-term potentiation_Homo sapiens_hsa047201.13782163
36Tight junction_Homo sapiens_hsa045301.11793392
37Salivary secretion_Homo sapiens_hsa049701.07899364
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07104683
39Adipocytokine signaling pathway_Homo sapiens_hsa049201.06132167
40AMPK signaling pathway_Homo sapiens_hsa041521.03053417
41Calcium signaling pathway_Homo sapiens_hsa040201.01872412
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96901440
43Central carbon metabolism in cancer_Homo sapiens_hsa052300.93379057
44HIF-1 signaling pathway_Homo sapiens_hsa040660.92014856
45Pentose phosphate pathway_Homo sapiens_hsa000300.88321400
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.87520939
47Amphetamine addiction_Homo sapiens_hsa050310.84850719
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80458379
49Circadian entrainment_Homo sapiens_hsa047130.78325207
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74719476
51RNA transport_Homo sapiens_hsa030130.74603809
52Glycerophospholipid metabolism_Homo sapiens_hsa005640.72454974
53Arginine and proline metabolism_Homo sapiens_hsa003300.69436472
54Focal adhesion_Homo sapiens_hsa045100.68667510
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68382177
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67830567
57Phototransduction_Homo sapiens_hsa047440.66308258
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65320456
59Fatty acid elongation_Homo sapiens_hsa000620.63487741
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63079252
61PPAR signaling pathway_Homo sapiens_hsa033200.59305722
62Butanoate metabolism_Homo sapiens_hsa006500.58656519
63Fatty acid biosynthesis_Homo sapiens_hsa000610.57709044
64Inositol phosphate metabolism_Homo sapiens_hsa005620.55248892
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.52187053
66Dorso-ventral axis formation_Homo sapiens_hsa043200.51978149
67Long-term depression_Homo sapiens_hsa047300.51578466
68Adherens junction_Homo sapiens_hsa045200.48461068
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47231692
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46987717
71FoxO signaling pathway_Homo sapiens_hsa040680.45789111
72Oocyte meiosis_Homo sapiens_hsa041140.45467083
73RNA degradation_Homo sapiens_hsa030180.45309993
74Cholinergic synapse_Homo sapiens_hsa047250.43103108
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42789460
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41910716
77Pancreatic secretion_Homo sapiens_hsa049720.38694296
78Serotonergic synapse_Homo sapiens_hsa047260.38301601
79Metabolic pathways_Homo sapiens_hsa011000.38063942
80GnRH signaling pathway_Homo sapiens_hsa049120.33075258
81beta-Alanine metabolism_Homo sapiens_hsa004100.32874825
82Purine metabolism_Homo sapiens_hsa002300.32844566
83ABC transporters_Homo sapiens_hsa020100.30131132
84Basal cell carcinoma_Homo sapiens_hsa052170.29994636
85Phenylalanine metabolism_Homo sapiens_hsa003600.29645269
86Taste transduction_Homo sapiens_hsa047420.27884515
87Glutamatergic synapse_Homo sapiens_hsa047240.27527839
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26928713
89Type II diabetes mellitus_Homo sapiens_hsa049300.26504560
90Gastric acid secretion_Homo sapiens_hsa049710.26467838
91Peroxisome_Homo sapiens_hsa041460.26310039
92Linoleic acid metabolism_Homo sapiens_hsa005910.24956638
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24772455
94Hippo signaling pathway_Homo sapiens_hsa043900.24673739
95Insulin secretion_Homo sapiens_hsa049110.24414898
96Lysine degradation_Homo sapiens_hsa003100.23968158
97Dopaminergic synapse_Homo sapiens_hsa047280.23770110
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23721962
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23084188
100mTOR signaling pathway_Homo sapiens_hsa041500.22977443
101Arginine biosynthesis_Homo sapiens_hsa002200.22797340
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.21917879
103Renin secretion_Homo sapiens_hsa049240.21702026
104Regulation of autophagy_Homo sapiens_hsa041400.20340212
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19533617
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18918071
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18581342
108VEGF signaling pathway_Homo sapiens_hsa043700.17618535
109Tryptophan metabolism_Homo sapiens_hsa003800.17597382
110Proteoglycans in cancer_Homo sapiens_hsa052050.17557214
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16544994
112Proteasome_Homo sapiens_hsa030500.15399492
113Tyrosine metabolism_Homo sapiens_hsa003500.15339760
114Ovarian steroidogenesis_Homo sapiens_hsa049130.14500669
115Sulfur metabolism_Homo sapiens_hsa009200.12991717
116MAPK signaling pathway_Homo sapiens_hsa040100.12935908
117cAMP signaling pathway_Homo sapiens_hsa040240.12882514
118TGF-beta signaling pathway_Homo sapiens_hsa043500.12574618
119Hedgehog signaling pathway_Homo sapiens_hsa043400.10588936
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09025521
121Glycerolipid metabolism_Homo sapiens_hsa005610.08780488
122Melanogenesis_Homo sapiens_hsa049160.06912871
123Renal cell carcinoma_Homo sapiens_hsa052110.06839503
124Amoebiasis_Homo sapiens_hsa051460.06567030
125Cell cycle_Homo sapiens_hsa041100.06309401
126Arachidonic acid metabolism_Homo sapiens_hsa005900.04948876
127Platelet activation_Homo sapiens_hsa046110.04592336
128Wnt signaling pathway_Homo sapiens_hsa043100.03272450

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