ASB13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants, both protein-coding and not protein-coding, have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)6.05543237
2L-phenylalanine metabolic process (GO:0006558)5.74758228
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.74758228
4L-phenylalanine catabolic process (GO:0006559)5.63844917
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.63844917
6aromatic amino acid family catabolic process (GO:0009074)5.42792834
7indole-containing compound catabolic process (GO:0042436)5.29016856
8indolalkylamine catabolic process (GO:0046218)5.29016856
9tryptophan catabolic process (GO:0006569)5.29016856
10NADH metabolic process (GO:0006734)5.25911229
11proline metabolic process (GO:0006560)4.99696528
12proline biosynthetic process (GO:0006561)4.97856150
13kynurenine metabolic process (GO:0070189)4.97782838
14tryptophan metabolic process (GO:0006568)4.87269507
15sulfur amino acid catabolic process (GO:0000098)4.84924390
16omega-hydroxylase P450 pathway (GO:0097267)4.75210679
17glyoxylate metabolic process (GO:0046487)4.70927262
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.53749083
19drug metabolic process (GO:0017144)4.50264965
20bile acid biosynthetic process (GO:0006699)4.48896887
21high-density lipoprotein particle remodeling (GO:0034375)4.30244874
22fat-soluble vitamin biosynthetic process (GO:0042362)4.29943325
23cellular glucuronidation (GO:0052695)4.20159879
24serine family amino acid catabolic process (GO:0009071)4.19084510
25ethanol oxidation (GO:0006069)4.15865438
26bile acid metabolic process (GO:0008206)4.11487576
27glutamine family amino acid biosynthetic process (GO:0009084)4.04940852
28glucuronate metabolic process (GO:0019585)4.00038214
29uronic acid metabolic process (GO:0006063)4.00038214
30aromatic amino acid family metabolic process (GO:0009072)3.99490899
31acylglycerol homeostasis (GO:0055090)3.98254943
32triglyceride homeostasis (GO:0070328)3.98254943
33lysine catabolic process (GO:0006554)3.97323854
34lysine metabolic process (GO:0006553)3.97323854
35cysteine metabolic process (GO:0006534)3.96205372
36regulation of cholesterol esterification (GO:0010872)3.95086238
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.94776449
38positive regulation of triglyceride lipase activity (GO:0061365)3.93634557
39positive regulation of lipoprotein lipase activity (GO:0051006)3.93634557
40ethanol metabolic process (GO:0006067)3.84974834
41glutamate metabolic process (GO:0006536)3.84071444
42alpha-amino acid catabolic process (GO:1901606)3.82644587
43alpha-linolenic acid metabolic process (GO:0036109)3.79049905
44urea cycle (GO:0000050)3.74121928
45urea metabolic process (GO:0019627)3.74121928
46heme transport (GO:0015886)3.70175371
47very-low-density lipoprotein particle assembly (GO:0034379)3.69563544
48cholesterol efflux (GO:0033344)3.68647576
49dicarboxylic acid biosynthetic process (GO:0043650)3.68584686
50negative regulation of fatty acid biosynthetic process (GO:0045717)3.67756771
51indolalkylamine metabolic process (GO:0006586)3.66884626
52cellular amino acid catabolic process (GO:0009063)3.66826578
53regulation of cholesterol homeostasis (GO:2000188)3.65792041
54glycine metabolic process (GO:0006544)3.65379758
55cellular ketone body metabolic process (GO:0046950)3.65056116
56drug catabolic process (GO:0042737)3.64772023
57protein carboxylation (GO:0018214)3.63900780
58peptidyl-glutamic acid carboxylation (GO:0017187)3.63900780
59cellular biogenic amine catabolic process (GO:0042402)3.61287708
60amine catabolic process (GO:0009310)3.61287708
61fructose metabolic process (GO:0006000)3.60583954
62regulation of protein activation cascade (GO:2000257)3.60223288
63cytolysis (GO:0019835)3.59375462
64phospholipid efflux (GO:0033700)3.59207371
65drug transmembrane transport (GO:0006855)3.56857625
66plasma lipoprotein particle remodeling (GO:0034369)3.56389231
67protein-lipid complex remodeling (GO:0034368)3.56389231
68macromolecular complex remodeling (GO:0034367)3.56389231
69amino-acid betaine metabolic process (GO:0006577)3.56031391
70coenzyme catabolic process (GO:0009109)3.55704792
71transcription from mitochondrial promoter (GO:0006390)3.54741583
72negative regulation of fibrinolysis (GO:0051918)3.54326609
73regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.53792836
74complement activation, alternative pathway (GO:0006957)3.53401140
75reverse cholesterol transport (GO:0043691)3.53011158
76urate metabolic process (GO:0046415)3.50344159
77primary alcohol catabolic process (GO:0034310)3.49829162
78angiotensin maturation (GO:0002003)3.49698767
79nitrogen cycle metabolic process (GO:0071941)3.48627828
80regulation of cholesterol metabolic process (GO:0090181)3.45969631
81regulation of fibrinolysis (GO:0051917)3.45465399
82negative regulation of cholesterol transport (GO:0032375)3.44889269
83negative regulation of sterol transport (GO:0032372)3.44889269
84intestinal cholesterol absorption (GO:0030299)3.44294830
85homocysteine metabolic process (GO:0050667)3.39509584
86polyketide metabolic process (GO:0030638)3.38751963
87doxorubicin metabolic process (GO:0044598)3.38751963
88daunorubicin metabolic process (GO:0044597)3.38751963
89oxaloacetate metabolic process (GO:0006107)3.38511165
90NAD biosynthetic process (GO:0009435)3.38277481
91acetyl-CoA metabolic process (GO:0006084)3.37310206
92Golgi transport vesicle coating (GO:0048200)3.33564961
93COPI coating of Golgi vesicle (GO:0048205)3.33564961
94short-chain fatty acid metabolic process (GO:0046459)3.32304576
95regulation of complement activation (GO:0030449)3.31225369
96indole-containing compound metabolic process (GO:0042430)3.30345603
972-oxoglutarate metabolic process (GO:0006103)3.26864598
98benzene-containing compound metabolic process (GO:0042537)3.26634561
99hormone catabolic process (GO:0042447)3.25551459
100organic acid catabolic process (GO:0016054)3.21953797
101carboxylic acid catabolic process (GO:0046395)3.21953797
102exogenous drug catabolic process (GO:0042738)3.20368507
103cellular modified amino acid catabolic process (GO:0042219)3.17353121
104plasma lipoprotein particle assembly (GO:0034377)3.17295007
105NAD metabolic process (GO:0019674)3.16183104
106regulation of cholesterol biosynthetic process (GO:0045540)3.11514353
107regulation of triglyceride catabolic process (GO:0010896)3.10511534
108tyrosine metabolic process (GO:0006570)3.09532372
109glycosphingolipid catabolic process (GO:0046479)3.09505552
110regulation of bile acid biosynthetic process (GO:0070857)3.08938993
111bile acid and bile salt transport (GO:0015721)3.07728750
112tricarboxylic acid metabolic process (GO:0072350)3.07077297
113pyridine nucleotide biosynthetic process (GO:0019363)3.06777617
114nicotinamide nucleotide biosynthetic process (GO:0019359)3.06777617
115very long-chain fatty acid metabolic process (GO:0000038)3.06658062
116ketone body metabolic process (GO:1902224)3.06563937
117biotin metabolic process (GO:0006768)3.06194726
118low-density lipoprotein particle remodeling (GO:0034374)3.05062469
119aspartate family amino acid catabolic process (GO:0009068)3.03573860
120fibrinolysis (GO:0042730)3.02793171
121glucose 6-phosphate metabolic process (GO:0051156)3.02568190
122neuromuscular process controlling posture (GO:0050884)3.00518114
123aminoglycoside antibiotic metabolic process (GO:0030647)2.99567041
124phenylpropanoid metabolic process (GO:0009698)2.99237881
125fatty acid beta-oxidation (GO:0006635)2.98045691
126serine family amino acid biosynthetic process (GO:0009070)2.97815245
127DNA unwinding involved in DNA replication (GO:0006268)2.97147486
128protein retention in ER lumen (GO:0006621)2.97129885
129alkaloid metabolic process (GO:0009820)2.96892759
130monocarboxylic acid catabolic process (GO:0072329)2.96773148
131positive regulation of fatty acid biosynthetic process (GO:0045723)2.96257944
132blood coagulation, intrinsic pathway (GO:0007597)2.95797569
133regulation of fatty acid biosynthetic process (GO:0042304)2.94806601
134complement activation, classical pathway (GO:0006958)2.94214209
135intestinal absorption (GO:0050892)2.94138999
136response to mercury ion (GO:0046689)2.94072713
137nucleoside diphosphate biosynthetic process (GO:0009133)2.93952916
138flavonoid metabolic process (GO:0009812)2.93263237
139dicarboxylic acid catabolic process (GO:0043649)2.92531302
140serine family amino acid metabolic process (GO:0009069)2.91410171
141regulation of protein homooligomerization (GO:0032462)2.90028159
142fatty acid catabolic process (GO:0009062)2.89574670
143pinocytosis (GO:0006907)2.89562474
144gluconeogenesis (GO:0006094)2.84960803
145glycolipid catabolic process (GO:0019377)2.84394965
146positive regulation of lipid catabolic process (GO:0050996)2.83615256
147glycoside metabolic process (GO:0016137)2.81166551
148complement activation (GO:0006956)2.79178953
149monosaccharide biosynthetic process (GO:0046364)2.76680181
150positive regulation of cellular amine metabolic process (GO:0033240)2.76554991
151drug transport (GO:0015893)2.76180259
152hexose biosynthetic process (GO:0019319)2.72293134
153pentose-phosphate shunt (GO:0006098)2.72028509
154acute-phase response (GO:0006953)2.71689692
155folic acid metabolic process (GO:0046655)2.70521103

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.31480133
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.87676863
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.80866581
4FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.34648975
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.20550384
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.09736941
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.31456621
8E2F7_22180533_ChIP-Seq_HELA_Human3.18501266
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.15408537
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.88774145
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.54768809
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.53865157
13VDR_21846776_ChIP-Seq_THP-1_Human2.36002027
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.27162831
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.15853856
16ZNF263_19887448_ChIP-Seq_K562_Human2.09321195
17ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.08038644
18ERG_21242973_ChIP-ChIP_JURKAT_Human2.07189982
19MYC_22102868_ChIP-Seq_BL_Human2.06774489
20* RACK7_27058665_Chip-Seq_MCF-7_Human2.06183498
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.88329175
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86492460
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82676540
24REST_21632747_ChIP-Seq_MESCs_Mouse1.78983399
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.76733264
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74941751
27GBX2_23144817_ChIP-Seq_PC3_Human1.70327330
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.67653974
29RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.66989980
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62204697
31* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.62001097
32* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58276231
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56728273
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54733813
35P68_20966046_ChIP-Seq_HELA_Human1.50951613
36* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45763193
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43647004
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43268585
39* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43110337
40* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.40129797
41SA1_27219007_Chip-Seq_ERYTHROID_Human1.37583546
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37289962
43LXR_22292898_ChIP-Seq_THP-1_Human1.35723933
44HTT_18923047_ChIP-ChIP_STHdh_Human1.35311946
45* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33607879
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32789611
47CLOCK_20551151_ChIP-Seq_293T_Human1.30101983
48TCF7_22412390_ChIP-Seq_EML_Mouse1.29349052
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29260498
50BCOR_27268052_Chip-Seq_Bcells_Human1.28550426
51* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28150654
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28117012
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27695091
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26606362
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26308612
56KDM2B_26808549_Chip-Seq_DND41_Human1.26305105
57* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25575482
58MYC_18555785_ChIP-Seq_MESCs_Mouse1.23712584
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23621884
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20715156
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20710589
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20562094
63VDR_24763502_ChIP-Seq_THP-1_Human1.18865873
64NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18387687
65CREB1_26743006_Chip-Seq_LNCaP_Human1.17168426
66* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16702462
67* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15329633
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.15260062
69RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15234259
70* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14886052
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14653768
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13009518
73* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12904224
74* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11637866
75RARB_27405468_Chip-Seq_BRAIN_Mouse1.11474556
76CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11276875
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10402334
78VDR_22108803_ChIP-Seq_LS180_Human1.10390137
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10070710
80IRF8_22096565_ChIP-ChIP_GC-B_Human1.08528682
81* TET1_21451524_ChIP-Seq_MESCs_Mouse1.08133100
82* RARA_24833708_ChIP-Seq_LIVER_Mouse1.07989745
83* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07510986
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07440283
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07326306
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06671500
87* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06626361
88XRN2_22483619_ChIP-Seq_HELA_Human1.06263541
89KDM2B_26808549_Chip-Seq_K562_Human1.06243104
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05955642
91BP1_19119308_ChIP-ChIP_Hs578T_Human1.05163114
92RARB_24833708_ChIP-Seq_LIVER_Mouse1.02929152
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02607318
94SA1_27219007_Chip-Seq_Bcells_Human1.02321211
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.02278792
96EZH2_22144423_ChIP-Seq_EOC_Human1.02177533
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99543868
98CTCF_26484167_Chip-Seq_Bcells_Mouse0.97703524
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97436852
100ATF3_27146783_Chip-Seq_COLON_Human0.97098593
101MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97035085
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96261801
103JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95738453
104* HNF4A_19822575_ChIP-Seq_HepG2_Human0.95681902
105BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94598007
106SPI1_26923725_Chip-Seq_HPCs_Mouse0.94164356
107JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.94158185
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94077505
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93562577
110P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92760843
111NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91232794
112* FOXA2_19822575_ChIP-Seq_HepG2_Human0.90744941
113CTCF_27219007_Chip-Seq_Bcells_Human0.90296815
114SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89867107
115RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89012718
116SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86742161
117ETS1_21867929_ChIP-Seq_TH2_Mouse0.86502868
118DROSHA_22980978_ChIP-Seq_HELA_Human0.86268104
119TAF15_26573619_Chip-Seq_HEK293_Human0.86044299
120SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85354358
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84767001
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83860844
123MYC_27129775_Chip-Seq_CORNEA_Mouse0.82638812
124SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81506754
125TET1_21490601_ChIP-Seq_MESCs_Mouse0.81255822
126* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.80783817
127HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.75927564
128SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75160542
129NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.74300249
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.73762608
131IKZF1_21737484_ChIP-ChIP_HCT116_Human0.72107523
132SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.70440704
133* FLI1_21867929_ChIP-Seq_CD8_Mouse0.69922579
134* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.69761229
135BCAT_22108803_ChIP-Seq_LS180_Human0.69476561
136SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.69397304
137ESR2_21235772_ChIP-Seq_MCF-7_Human0.69018374
138ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.68993160
139FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.67846837
140* NANOG_16518401_ChIP-PET_MESCs_Mouse0.67685430
141SMC4_20622854_ChIP-Seq_HELA_Human0.67614423
142SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.65601772
143BCL6_27268052_Chip-Seq_Bcells_Human0.65169169
144IRF1_19129219_ChIP-ChIP_H3396_Human0.64228459
145PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.64153596
146TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.63133716
147OCT4_20526341_ChIP-Seq_ESCs_Human0.62152380
148RNF2_18974828_ChIP-Seq_MESCs_Mouse0.61467543
149EZH2_18974828_ChIP-Seq_MESCs_Mouse0.61467543
150EZH2_27294783_Chip-Seq_ESCs_Mouse0.61238141
151MYC_19915707_ChIP-ChIP_AK7_Human0.60266049
152JARID2_20064375_ChIP-Seq_MESCs_Mouse0.60254820
153TAF2_19829295_ChIP-Seq_ESCs_Human0.59696674
154POU5F1_16518401_ChIP-PET_MESCs_Mouse0.59492992
155SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.59432981
156E2F1_20622854_ChIP-Seq_HELA_Human0.59044220
157CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.58539195
158SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.58256128
159AR_25329375_ChIP-Seq_VCAP_Human0.57949330
160KLF4_19829295_ChIP-Seq_ESCs_Human0.57328412
161CTBP1_25329375_ChIP-Seq_LNCAP_Human0.56583914

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.72465226
2MP0005085_abnormal_gallbladder_physiolo5.76994681
3MP0005360_urolithiasis5.73231256
4MP0005365_abnormal_bile_salt5.71826978
5MP0008875_abnormal_xenobiotic_pharmacok3.75017718
6MP0005451_abnormal_body_composition3.70740237
7MP0010234_abnormal_vibrissa_follicle2.94494872
8MP0010329_abnormal_lipoprotein_level2.81505346
9MP0003252_abnormal_bile_duct2.72359632
10MP0003195_calcinosis2.66667364
11MP0003806_abnormal_nucleotide_metabolis2.63790466
12MP0005332_abnormal_amino_acid2.61987085
13MP0004019_abnormal_vitamin_homeostasis2.47555652
14MP0005083_abnormal_biliary_tract2.46477977
15MP0001666_abnormal_nutrient_absorption2.33487434
16MP0003705_abnormal_hypodermis_morpholog2.32904264
17MP0009840_abnormal_foam_cell2.23414282
18MP0002822_catalepsy2.16923671
19MP0004859_abnormal_synaptic_plasticity2.01322201
20MP0003183_abnormal_peptide_metabolism1.89726189
21MP0005409_darkened_coat_color1.88729572
22MP0003191_abnormal_cellular_cholesterol1.87708950
23MP0002118_abnormal_lipid_homeostasis1.85350179
24MP0004185_abnormal_adipocyte_glucose1.73622285
25MP0002138_abnormal_hepatobiliary_system1.69771948
26MP0001764_abnormal_homeostasis1.69512636
27MP0002876_abnormal_thyroid_physiology1.59984702
28MP0009046_muscle_twitch1.58634355
29MP0000609_abnormal_liver_physiology1.56882157
30MP0005666_abnormal_adipose_tissue1.52091335
31MP0005319_abnormal_enzyme/_coenzyme1.50264309
32MP0005646_abnormal_pituitary_gland1.48742529
33MP0005584_abnormal_enzyme/coenzyme_acti1.48671207
34MP0003868_abnormal_feces_composition1.47760516
35MP0001849_ear_inflammation1.46902513
36MP0002009_preneoplasia1.44184994
37MP0003635_abnormal_synaptic_transmissio1.43812267
38MP0002064_seizures1.41043794
39MP0008260_abnormal_autophagy1.40123261
40MP0004264_abnormal_extraembryonic_tissu1.37975274
41MP0003880_abnormal_central_pattern1.37161209
42MP0009745_abnormal_behavioral_response1.34445763
43MP0004043_abnormal_pH_regulation1.32361341
44MP0002063_abnormal_learning/memory/cond1.27995442
45MP0009278_abnormal_bone_marrow1.23590152
46MP0005535_abnormal_body_temperature1.23328841
47MP0002572_abnormal_emotion/affect_behav1.22243365
48MP0002796_impaired_skin_barrier1.20917896
49MP0002877_abnormal_melanocyte_morpholog1.20748300
50MP0004142_abnormal_muscle_tone1.19951283
51MP0003329_amyloid_beta_deposits1.18640435
52MP0005647_abnormal_sex_gland1.15933193
53MP0001501_abnormal_sleep_pattern1.15446215
54MP0009643_abnormal_urine_homeostasis1.14980005
55MP0001968_abnormal_touch/_nociception1.14700760
56MP0009697_abnormal_copulation1.12961293
57MP0004858_abnormal_nervous_system1.12681879
58MP0002396_abnormal_hematopoietic_system1.12251975
59MP0002078_abnormal_glucose_homeostasis1.10641731
60MP0002736_abnormal_nociception_after1.10611059
61MP0002909_abnormal_adrenal_gland1.09846286
62MP0005636_abnormal_mineral_homeostasis1.09741773
63MP0001502_abnormal_circadian_rhythm1.09055880
64MP0006036_abnormal_mitochondrial_physio1.08895617
65MP0005501_abnormal_skin_physiology1.06192397
66MP0002272_abnormal_nervous_system1.05900004
67MP0000678_abnormal_parathyroid_gland1.05659896
68MP0005084_abnormal_gallbladder_morpholo1.02261123
69MP0000639_abnormal_adrenal_gland1.00769241
70MP0003879_abnormal_hair_cell1.00416617
71MP0000490_abnormal_crypts_of1.00340985
72MP0005375_adipose_tissue_phenotype0.99922814
73MP0005166_decreased_susceptibility_to0.94461620
74MP0004233_abnormal_muscle_weight0.94328697
75MP0010352_gastrointestinal_tract_polyps0.94314309
76MP0002733_abnormal_thermal_nociception0.92962018
77MP0002067_abnormal_sensory_capabilities0.91971030
78MP0008874_decreased_physiological_sensi0.91039543
79MP0001984_abnormal_olfaction0.90597181
80MP0002735_abnormal_chemical_nociception0.90579308
81MP0000604_amyloidosis0.90056811
82MP0000003_abnormal_adipose_tissue0.89884518
83MP0005464_abnormal_platelet_physiology0.89717490
84MP0003656_abnormal_erythrocyte_physiolo0.89515350
85MP0005448_abnormal_energy_balance0.88682933
86MP0003453_abnormal_keratinocyte_physiol0.88163617
87MP0005645_abnormal_hypothalamus_physiol0.87124223
88MP0003283_abnormal_digestive_organ0.86479485
89MP0009642_abnormal_blood_homeostasis0.85518449
90MP0003953_abnormal_hormone_level0.85459839
91MP0005220_abnormal_exocrine_pancreas0.84529117
92MP0004130_abnormal_muscle_cell0.84505612
93MP0004782_abnormal_surfactant_physiolog0.83815778
94MP0002098_abnormal_vibrissa_morphology0.83473136
95MP0003633_abnormal_nervous_system0.83205336
96MP0002249_abnormal_larynx_morphology0.82244826
97MP0000681_abnormal_thyroid_gland0.81949949
98MP0010155_abnormal_intestine_physiology0.80963949
99MP0003866_abnormal_defecation0.80920802
100MP0000467_abnormal_esophagus_morphology0.80501076
101MP0001440_abnormal_grooming_behavior0.80106110
102MP0000747_muscle_weakness0.79645135
103MP0006035_abnormal_mitochondrial_morpho0.78818043
104MP0000477_abnormal_intestine_morphology0.77524025
105MP0005266_abnormal_metabolism0.76259568
106MP0009764_decreased_sensitivity_to0.75449102
107MP0001970_abnormal_pain_threshold0.74350372
108MP0003638_abnormal_response/metabolism_0.73881618
109MP0003693_abnormal_embryo_hatching0.72626947
110MP0003172_abnormal_lysosome_physiology0.72263346
111MP0000598_abnormal_liver_morphology0.70832006
112MP0002971_abnormal_brown_adipose0.69760070
113MP0005376_homeostasis/metabolism_phenot0.69327801
114MP0000579_abnormal_nail_morphology0.68312021
115MP0002069_abnormal_eating/drinking_beha0.68208078
116MP0008872_abnormal_physiological_respon0.68073525
117MP0009379_abnormal_foot_pigmentation0.67750032
118MP0005670_abnormal_white_adipose0.67731009
119MP0005075_abnormal_melanosome_morpholog0.67438648
120MP0004270_analgesia0.67239551
121MP0005386_behavior/neurological_phenoty0.67201199
122MP0004924_abnormal_behavior0.67201199
123MP0005171_absent_coat_pigmentation0.66313737
124MP0005397_hematopoietic_system_phenotyp0.66301895
125MP0001545_abnormal_hematopoietic_system0.66301895
126MP0000566_synostosis0.65860674
127MP0001765_abnormal_ion_homeostasis0.65761715
128MP0004947_skin_inflammation0.65695680
129MP0003300_gastrointestinal_ulcer0.65527379
130MP0005058_abnormal_lysosome_morphology0.65135253
131MP0001881_abnormal_mammary_gland0.65111140
132MP0003075_altered_response_to0.64279946
133MP0006276_abnormal_autonomic_nervous0.63917129
134MP0003690_abnormal_glial_cell0.63457938
135MP0009333_abnormal_splenocyte_physiolog0.63395403
136MP0010094_abnormal_chromosome_stability0.63350483
137MP0001486_abnormal_startle_reflex0.62436160
138MP0008469_abnormal_protein_level0.62099336
139MP0001756_abnormal_urination0.61774576
140MP0001664_abnormal_digestion0.61740844
141MP0000858_altered_metastatic_potential0.60778307
142MP0005379_endocrine/exocrine_gland_phen0.60319755
143MP0010386_abnormal_urinary_bladder0.60086584
144MP0005334_abnormal_fat_pad0.59353431
145MP0002970_abnormal_white_adipose0.59010864
146MP0008569_lethality_at_weaning0.58253639
147MP0002928_abnormal_bile_duct0.58217354
148MP0005551_abnormal_eye_electrophysiolog0.58193908
149MP0000462_abnormal_digestive_system0.56731043
150MP0003011_delayed_dark_adaptation0.56531989
151MP0001661_extended_life_span0.55307337
152MP0005330_cardiomyopathy0.55090263
153MP0009931_abnormal_skin_appearance0.54451656
154MP0002132_abnormal_respiratory_system0.54358254
155MP0002136_abnormal_kidney_physiology0.54264767
156MP0003436_decreased_susceptibility_to0.54172198

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.67535861
2Intrahepatic cholestasis (HP:0001406)4.96217542
3Hypobetalipoproteinemia (HP:0003563)4.75416955
4Prolonged partial thromboplastin time (HP:0003645)4.40957658
5Deep venous thrombosis (HP:0002625)4.32852645
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.19317240
7Ketosis (HP:0001946)4.11248567
8Ketoacidosis (HP:0001993)4.05756781
9Xanthomatosis (HP:0000991)4.05714274
10Hyperglycinemia (HP:0002154)4.01852218
11Gout (HP:0001997)3.86069556
12Hyperglycinuria (HP:0003108)3.81471196
13Hyperammonemia (HP:0001987)3.69050748
14Hyperlipoproteinemia (HP:0010980)3.59004196
15Conjugated hyperbilirubinemia (HP:0002908)3.43445122
16Abnormality of glycine metabolism (HP:0010895)3.43405902
17Abnormality of serine family amino acid metabolism (HP:0010894)3.43405902
18Complement deficiency (HP:0004431)3.36012574
19Hypochromic microcytic anemia (HP:0004840)3.34646057
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.23648844
21Hypolipoproteinemia (HP:0010981)3.20307282
22Focal motor seizures (HP:0011153)3.16735006
23Fat malabsorption (HP:0002630)3.15687915
24Joint hemorrhage (HP:0005261)3.13646500
25Hypoglycemic coma (HP:0001325)3.12290253
26Glomerulonephritis (HP:0000099)3.10437767
27Status epilepticus (HP:0002133)2.96513168
28Abnormality of purine metabolism (HP:0004352)2.96307976
29Abnormality of the common coagulation pathway (HP:0010990)2.95067864
30Abnormality of sulfur amino acid metabolism (HP:0004339)2.94832024
31Hemorrhage of the eye (HP:0011885)2.84942982
32Abnormality of aspartate family amino acid metabolism (HP:0010899)2.82388403
33Hypoglycemic seizures (HP:0002173)2.75808075
34Epidermoid cyst (HP:0200040)2.75723221
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.75383769
36Hyperventilation (HP:0002883)2.73107360
37Hyperbilirubinemia (HP:0002904)2.69070549
38Febrile seizures (HP:0002373)2.69042152
39Generalized aminoaciduria (HP:0002909)2.67669611
40Delayed CNS myelination (HP:0002188)2.67382957
41Abnormality of nucleobase metabolism (HP:0010932)2.66771894
42Lethargy (HP:0001254)2.65831425
43Abnormality of serum amino acid levels (HP:0003112)2.63643167
44Metabolic acidosis (HP:0001942)2.59679085
45Ragged-red muscle fibers (HP:0003200)2.57439142
46Abnormality of methionine metabolism (HP:0010901)2.53471506
47Acute hepatic failure (HP:0006554)2.52024174
48Abnormality of the intrinsic pathway (HP:0010989)2.49886431
49Abnormality of fatty-acid metabolism (HP:0004359)2.49613970
50Increased cerebral lipofuscin (HP:0011813)2.48516636
51Abnormality of the Achilles tendon (HP:0005109)2.48262815
52Lower limb hyperreflexia (HP:0002395)2.47759263
53Rhabdomyolysis (HP:0003201)2.45751666
54Growth hormone excess (HP:0000845)2.43893717
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.43642133
56Sensorimotor neuropathy (HP:0007141)2.40691235
57Hypoalphalipoproteinemia (HP:0003233)2.40625170
58Irritability (HP:0000737)2.40287985
59Spontaneous abortion (HP:0005268)2.38830085
60Cerebral palsy (HP:0100021)2.38570539
61Centrally nucleated skeletal muscle fibers (HP:0003687)2.38376278
62Atonic seizures (HP:0010819)2.37808436
63Myokymia (HP:0002411)2.37411524
64Steatorrhea (HP:0002570)2.36948410
65Vertebral compression fractures (HP:0002953)2.31942431
66Abnormality of glycolysis (HP:0004366)2.31608989
67Purpura (HP:0000979)2.30310997
68Hyperinsulinemic hypoglycemia (HP:0000825)2.29913324
69Epileptic encephalopathy (HP:0200134)2.29558046
70Opisthotonus (HP:0002179)2.29253837
71Reticulocytosis (HP:0001923)2.28451044
72Late onset (HP:0003584)2.28360362
73Increased IgM level (HP:0003496)2.27575508
74Alkalosis (HP:0001948)2.27435391
75Increased neuronal autofluorescent lipopigment (HP:0002074)2.26465850
76Increased purine levels (HP:0004368)2.22201153
77Hyperuricemia (HP:0002149)2.22201153
78Exercise-induced myalgia (HP:0003738)2.21395791
79Symptomatic seizures (HP:0011145)2.21335032
80Nephritis (HP:0000123)2.21152752
81Abnormality of complement system (HP:0005339)2.19977913
82Turricephaly (HP:0000262)2.18885296
83Achilles tendon contracture (HP:0001771)2.18069173
84Increased serum pyruvate (HP:0003542)2.17674640
85J-shaped sella turcica (HP:0002680)2.16412250
86Abdominal distention (HP:0003270)2.16165512
87Thin bony cortex (HP:0002753)2.16154668
88Recurrent gram-negative bacterial infections (HP:0005420)2.16074129
89Neonatal onset (HP:0003623)2.16048281
90Cholecystitis (HP:0001082)2.15932189
91Abnormal gallbladder physiology (HP:0012438)2.15932189
92Cerebral edema (HP:0002181)2.14395991
93Vomiting (HP:0002013)2.11454596
94Spastic paraparesis (HP:0002313)2.10673817
95Urinary glycosaminoglycan excretion (HP:0003541)2.10032986
96Mucopolysacchariduria (HP:0008155)2.10032986
97Absence seizures (HP:0002121)2.08750428
98Pustule (HP:0200039)2.08118740
99Abnormality of pyrimidine metabolism (HP:0004353)2.07699728
100Abnormality of polysaccharide metabolism (HP:0011012)2.04895301
101Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04895301
102Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04895301
103Abnormality of dicarboxylic acid metabolism (HP:0010995)2.04623291
104Dicarboxylic aciduria (HP:0003215)2.04623291
105Elevated alkaline phosphatase (HP:0003155)2.04471360
106Dysostosis multiplex (HP:0000943)2.03853332
107Microvesicular hepatic steatosis (HP:0001414)2.03065030
108Stroke (HP:0001297)2.01948037
109Hypercholesterolemia (HP:0003124)2.01851211
110Abnormality of endocrine pancreas physiology (HP:0012093)2.01744832
111Abnormality of the pancreatic islet cells (HP:0006476)2.01744832
112Hyperparathyroidism (HP:0000843)2.01609256
113Paraparesis (HP:0002385)1.98456932
114Wide cranial sutures (HP:0010537)1.98210284
115Amyloidosis (HP:0011034)1.97492538
116Progressive muscle weakness (HP:0003323)1.96815377
117Pili torti (HP:0003777)1.96355106
118Malnutrition (HP:0004395)1.94425013
119Menorrhagia (HP:0000132)1.94025038
120Back pain (HP:0003418)1.93970274
121Abnormality of alkaline phosphatase activity (HP:0004379)1.93607284
122Polygenic inheritance (HP:0010982)1.93600196
123Pancreatic islet-cell hyperplasia (HP:0004510)1.92821719
124Flat acetabular roof (HP:0003180)1.92296487
125Cholelithiasis (HP:0001081)1.92211565
126Alopecia of scalp (HP:0002293)1.90715877
127Visual hallucinations (HP:0002367)1.90283201
128Increased serum ferritin (HP:0003281)1.89140886
129Annular pancreas (HP:0001734)1.88941191
130Seborrheic dermatitis (HP:0001051)1.87933257
131Abnormality of the lower motor neuron (HP:0002366)1.87150143
132Neurofibrillary tangles (HP:0002185)1.86609618
133Distal lower limb muscle weakness (HP:0009053)1.85802879
134Axonal loss (HP:0003447)1.85672714
135Abnormal enzyme/coenzyme activity (HP:0012379)1.84726667
136Abnormal cartilage morphology (HP:0002763)1.84569407
137Hyperacusis (HP:0010780)1.84326825
138Abnormality of proline metabolism (HP:0010907)1.82130344
139Hydroxyprolinuria (HP:0003080)1.82130344
140Hypophosphatemia (HP:0002148)1.81105559
141Dysautonomia (HP:0002459)1.81050785
142Mitral stenosis (HP:0001718)1.81010446
143Prolonged neonatal jaundice (HP:0006579)1.79739499
144Cellulitis (HP:0100658)1.79337588
145Myoglobinuria (HP:0002913)1.78931144
146Poor suck (HP:0002033)1.78505147
147Abnormality of the periventricular white matter (HP:0002518)1.77343415
148Myopathic facies (HP:0002058)1.77257313
149Abnormality of glycolipid metabolism (HP:0010969)1.76608918
150Abnormality of liposaccharide metabolism (HP:0010968)1.76608918
151Abnormality of glycosphingolipid metabolism (HP:0004343)1.76608918
152Myocardial infarction (HP:0001658)1.76288305
153Hypotension (HP:0002615)1.75993939
154Neuronal loss in central nervous system (HP:0002529)1.75273579
155Widely patent fontanelles and sutures (HP:0004492)1.74794631
156Bone pain (HP:0002653)1.74763043
157Dialeptic seizures (HP:0011146)1.73635003
158Systemic lupus erythematosus (HP:0002725)1.73030557
159Oligomenorrhea (HP:0000876)1.72632440
160Epileptiform EEG discharges (HP:0011182)1.72628537

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.61745073
2MAPK153.85316145
3PINK13.78609953
4RIPK13.61912206
5BCKDK3.11390213
6DAPK13.04866550
7SCYL22.91228161
8TESK22.89246175
9MAP3K62.84191627
10NTRK32.79661043
11EEF2K2.70172300
12MAP3K112.65316692
13ICK2.60854430
14IRAK32.56401608
15SIK32.52576339
16EPHA42.50881381
17SMG12.50592740
18MAP2K72.34678898
19NME22.33472232
20TESK12.22351940
21DAPK22.13272692
22INSRR2.06068718
23MAP2K42.04408447
24STK162.04352661
25MAP3K121.98342966
26EPHA21.97390304
27AKT31.95174341
28MST1R1.89048299
29DDR21.81109507
30MATK1.75093210
31MAP3K41.74158903
32CASK1.64259340
33FGFR41.62736255
34PKN21.59184936
35PRPF4B1.55970236
36SIK11.52159178
37FGR1.47481726
38KSR21.31117581
39YES11.30727469
40MAP3K91.26008169
41STK381.23685503
42MINK11.22601156
43DYRK1B1.22517451
44MAP2K21.22508719
45MAP3K101.22063946
46PDPK11.19622012
47MAPK111.18292356
48PRKD21.16150884
49UHMK11.12978595
50BRAF1.09322979
51MAP2K31.07952184
52RIPK41.06739020
53PDK21.06040471
54TYRO31.05883968
55VRK21.04526712
56CSK1.04283071
57SIK21.04009130
58ERN11.03612558
59KDR1.03498528
60CAMK2G1.02134981
61TBK10.99502571
62MAPKAPK30.99309264
63PTK60.96350774
64PHKG20.95592493
65PHKG10.95592493
66TAOK20.95001790
67PRKD30.94941466
68TNK20.94183212
69PRKCG0.94088949
70BMX0.91516068
71LMTK20.89117368
72IRAK20.85056615
73MAP3K130.84607636
74CDK120.83984494
75CDK190.83280100
76PRKG20.81142368
77PRKAA10.81101348
78SGK20.80508979
79ABL20.78031606
80PAK40.77988650
81CDK70.77205685
82CAMK2B0.76789723
83RPS6KB20.74582329
84CSF1R0.72484485
85CDK40.72210052
86LRRK20.72027432
87PDGFRA0.71291378
88PDK10.70663217
89ALK0.70329498
90CAMKK10.70270890
91CAMK2A0.70111566
92PRKCZ0.67585424
93PIM20.67069978
94NTRK20.66526383
95SGK30.65915754
96CDC42BPA0.65683707
97MAP3K80.65372029
98MAP3K30.65168987
99LIMK10.64603688
100MAP3K10.63638217
101PDK40.62830227
102PDK30.62830227
103MTOR0.62779753
104RPS6KA20.59831434
105OXSR10.59589938
106TNIK0.59570707
107NTRK10.59524719
108SGK2230.58217536
109SGK4940.58217536
110CAMKK20.58000447
111CDK80.57824239
112GSK3A0.56942640
113MET0.55596680
114GRK50.55565394
115JAK20.54903733
116CCNB10.54479784
117BMPR20.52106498
118RET0.51868437
119ERBB40.51825751
120PRKAA20.51386570
121TAOK30.51344761
122SGK10.50879203
123CDK60.49385442
124JAK10.49154665
125CDK50.49086874
126PRKACG0.48102101
127MAP2K60.47685358
128GRK60.47112547
129AURKA0.46465511
130MAP3K70.44673792
131RPS6KL10.44570798
132RPS6KC10.44570798
133STK38L0.44402510
134TAOK10.44289750
135RPS6KB10.43778132
136HIPK20.43739764
137MAPK120.43396831
138MAPK40.42841799
139PRKCH0.41767890
140WNK30.41551706
141CAMK2D0.41023632
142NEK10.40776837
143PBK0.40756659
144AKT20.40750062
145TTN0.40587343
146CAMK10.40575645
147KSR10.39733622
148LATS20.39122430
149TYK20.38365187
150RPS6KA40.37904570
151RAF10.36509771
152MAP4K10.36375430
153NEK60.35395932
154ARAF0.35226868
155PRKCI0.33861959
156FLT30.33149350
157ATR0.33052829
158RPS6KA30.32804785
159ILK0.31805853
160ZAP700.31373715
161CDK150.29186883
162EIF2AK10.28800181
163CDK11A0.27979865

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.88019003
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.79345039
3Arginine biosynthesis_Homo sapiens_hsa002202.98992332
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.65550457
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.65386279
6Nitrogen metabolism_Homo sapiens_hsa009102.56892390
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.50910076
8Tryptophan metabolism_Homo sapiens_hsa003802.35227963
9Butanoate metabolism_Homo sapiens_hsa006502.33163917
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.24998056
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.15410839
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.13999144
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.05987797
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05128787
15Fatty acid metabolism_Homo sapiens_hsa012121.93815989
16Fatty acid degradation_Homo sapiens_hsa000711.93583970
17Propanoate metabolism_Homo sapiens_hsa006401.92822994
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.87594139
19Peroxisome_Homo sapiens_hsa041461.86671773
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.85666467
21Complement and coagulation cascades_Homo sapiens_hsa046101.83825019
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.77817191
23Fatty acid biosynthesis_Homo sapiens_hsa000611.77003489
24Other glycan degradation_Homo sapiens_hsa005111.61755648
25beta-Alanine metabolism_Homo sapiens_hsa004101.60813520
26Pyruvate metabolism_Homo sapiens_hsa006201.56980475
27Histidine metabolism_Homo sapiens_hsa003401.47046586
28Phenylalanine metabolism_Homo sapiens_hsa003601.46669824
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46162542
30Bile secretion_Homo sapiens_hsa049761.44164081
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39539262
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36520796
33PPAR signaling pathway_Homo sapiens_hsa033201.35118968
34Folate biosynthesis_Homo sapiens_hsa007901.34161910
35Sulfur relay system_Homo sapiens_hsa041221.34143840
36Biosynthesis of amino acids_Homo sapiens_hsa012301.31746838
37Arginine and proline metabolism_Homo sapiens_hsa003301.29951245
38Synaptic vesicle cycle_Homo sapiens_hsa047211.26819326
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26652938
40Chemical carcinogenesis_Homo sapiens_hsa052041.26650062
41Nicotine addiction_Homo sapiens_hsa050331.24370363
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.23066667
43Sulfur metabolism_Homo sapiens_hsa009201.22265644
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21980437
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21261171
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.18233860
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.16164353
48Starch and sucrose metabolism_Homo sapiens_hsa005001.12916734
49ABC transporters_Homo sapiens_hsa020101.12009688
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.12008387
51Renin-angiotensin system_Homo sapiens_hsa046141.08856806
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.08260971
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06484875
54Retinol metabolism_Homo sapiens_hsa008301.05234862
55DNA replication_Homo sapiens_hsa030301.02778466
56Fatty acid elongation_Homo sapiens_hsa000621.00177880
57Carbon metabolism_Homo sapiens_hsa012000.99443872
58Collecting duct acid secretion_Homo sapiens_hsa049660.98904330
59Staphylococcus aureus infection_Homo sapiens_hsa051500.98568767
60Tyrosine metabolism_Homo sapiens_hsa003500.96744142
61Selenocompound metabolism_Homo sapiens_hsa004500.95500229
62Base excision repair_Homo sapiens_hsa034100.92129932
63Vitamin digestion and absorption_Homo sapiens_hsa049770.91124967
64Fat digestion and absorption_Homo sapiens_hsa049750.88004658
65GABAergic synapse_Homo sapiens_hsa047270.87311971
66Circadian rhythm_Homo sapiens_hsa047100.82419128
67Caffeine metabolism_Homo sapiens_hsa002320.80677669
68Glycerolipid metabolism_Homo sapiens_hsa005610.78591606
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76950565
70Fructose and mannose metabolism_Homo sapiens_hsa000510.76807548
71Arachidonic acid metabolism_Homo sapiens_hsa005900.76243027
72Vitamin B6 metabolism_Homo sapiens_hsa007500.71649277
73One carbon pool by folate_Homo sapiens_hsa006700.67703631
74Insulin secretion_Homo sapiens_hsa049110.62215665
75Lysine degradation_Homo sapiens_hsa003100.59880869
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58470767
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55958319
78Linoleic acid metabolism_Homo sapiens_hsa005910.54620609
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.53709348
80Amphetamine addiction_Homo sapiens_hsa050310.51601068
81Olfactory transduction_Homo sapiens_hsa047400.51484933
82Steroid biosynthesis_Homo sapiens_hsa001000.50862066
83Regulation of autophagy_Homo sapiens_hsa041400.49863628
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46788616
85Galactose metabolism_Homo sapiens_hsa000520.46301334
86Morphine addiction_Homo sapiens_hsa050320.44578949
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43220360
88Metabolic pathways_Homo sapiens_hsa011000.43121784
89Glucagon signaling pathway_Homo sapiens_hsa049220.42758480
90Non-small cell lung cancer_Homo sapiens_hsa052230.42713095
91Taste transduction_Homo sapiens_hsa047420.42132409
92Mineral absorption_Homo sapiens_hsa049780.41591883
93Lysosome_Homo sapiens_hsa041420.40939521
94AMPK signaling pathway_Homo sapiens_hsa041520.39343515
95Circadian entrainment_Homo sapiens_hsa047130.35572292
96Acute myeloid leukemia_Homo sapiens_hsa052210.34878817
97Insulin resistance_Homo sapiens_hsa049310.34177921
98Prion diseases_Homo sapiens_hsa050200.32648579
99Pertussis_Homo sapiens_hsa051330.32218365
100Glutathione metabolism_Homo sapiens_hsa004800.32088062
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.32030458
102Glutamatergic synapse_Homo sapiens_hsa047240.32018191
103Thyroid cancer_Homo sapiens_hsa052160.31196622
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.31047028
105Bladder cancer_Homo sapiens_hsa052190.30030257
106Pyrimidine metabolism_Homo sapiens_hsa002400.25507993
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25366981
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24230530
109Salivary secretion_Homo sapiens_hsa049700.23460776
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22176103
111Chronic myeloid leukemia_Homo sapiens_hsa052200.22013395
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21759195
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20927028
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20110870
115Pentose phosphate pathway_Homo sapiens_hsa000300.19194082
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19102934
117Long-term potentiation_Homo sapiens_hsa047200.18274840
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18237524
119Sphingolipid metabolism_Homo sapiens_hsa006000.17827035
120Insulin signaling pathway_Homo sapiens_hsa049100.17469379
121Dopaminergic synapse_Homo sapiens_hsa047280.16238558
122Vibrio cholerae infection_Homo sapiens_hsa051100.14206994
123Pancreatic cancer_Homo sapiens_hsa052120.14047432
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.13073084
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12149303
126B cell receptor signaling pathway_Homo sapiens_hsa046620.11237612
127VEGF signaling pathway_Homo sapiens_hsa043700.10740378
128Mismatch repair_Homo sapiens_hsa034300.08174916
129N-Glycan biosynthesis_Homo sapiens_hsa005100.07936366
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04941785

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