ASB14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)8.52650660
2actin-myosin filament sliding (GO:0033275)8.19721862
3muscle filament sliding (GO:0030049)8.19721862
4regulation of skeletal muscle contraction (GO:0014819)7.88629836
5positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.58774922
6sarcoplasmic reticulum calcium ion transport (GO:0070296)7.46224068
7myofibril assembly (GO:0030239)7.37472770
8cardiac myofibril assembly (GO:0055003)7.26672923
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)7.07308401
10negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.05202704
11actin-mediated cell contraction (GO:0070252)6.75319823
12tricarboxylic acid cycle (GO:0006099)6.52212300
13regulation of relaxation of muscle (GO:1901077)6.29135920
14plasma membrane repair (GO:0001778)6.26015849
15negative regulation of potassium ion transmembrane transport (GO:1901380)6.21726237
16cardiac muscle contraction (GO:0060048)6.10663426
17regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.07401435
18regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)6.01571867
19carnitine shuttle (GO:0006853)5.97900672
20regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.91685894
21regulation of cell communication by electrical coupling (GO:0010649)5.84006241
22skeletal muscle contraction (GO:0003009)5.80287633
23regulation of actin filament-based movement (GO:1903115)5.80100580
24striated muscle contraction (GO:0006941)5.75769661
25regulation of acyl-CoA biosynthetic process (GO:0050812)5.49100766
26actomyosin structure organization (GO:0031032)5.42906903
27cardiac muscle cell development (GO:0055013)5.40423928
28creatine metabolic process (GO:0006600)5.39166186
29regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.34894596
30response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.29479641
31fatty acid transmembrane transport (GO:1902001)5.18178842
32skeletal muscle adaptation (GO:0043501)5.15766997
33regulation of sarcomere organization (GO:0060297)5.10450390
34skeletal muscle fiber development (GO:0048741)5.08124292
35cardiac cell development (GO:0055006)5.06561538
36regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.05574880
37actin filament-based movement (GO:0030048)5.03161135
38cardiac muscle hypertrophy (GO:0003300)5.03044235
39regulation of coenzyme metabolic process (GO:0051196)4.97556408
40regulation of cofactor metabolic process (GO:0051193)4.97556408
41striated muscle hypertrophy (GO:0014897)4.87968363
42myotube cell development (GO:0014904)4.87877117
43heart process (GO:0003015)4.83148617
44heart contraction (GO:0060047)4.83148617
45muscle fiber development (GO:0048747)4.74992355
46regulation of striated muscle contraction (GO:0006942)4.72885519
47ventricular cardiac muscle cell action potential (GO:0086005)4.71381139
48cardiac muscle tissue morphogenesis (GO:0055008)4.61909611
49muscle atrophy (GO:0014889)4.46962155
50carnitine transmembrane transport (GO:1902603)4.45834223
51adult heart development (GO:0007512)4.42391889
52heart trabecula formation (GO:0060347)4.41028184
53bundle of His cell to Purkinje myocyte communication (GO:0086069)4.33590024
54skeletal muscle tissue development (GO:0007519)4.33508213
55muscle hypertrophy (GO:0014896)4.31307630
56regulation of membrane repolarization (GO:0060306)4.31101506
57muscle tissue morphogenesis (GO:0060415)4.25377775
58skeletal muscle tissue regeneration (GO:0043403)4.25349266
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.24612390
60muscle contraction (GO:0006936)4.18913594
61muscle organ morphogenesis (GO:0048644)4.17632673
62response to inactivity (GO:0014854)4.12153512
63striated muscle adaptation (GO:0014888)4.11005658
64glycogen catabolic process (GO:0005980)4.10978534
65regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.09295127
66positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.07141734
67carnitine transport (GO:0015879)4.05558732
68amino-acid betaine transport (GO:0015838)4.05558732
69regulation of sulfur metabolic process (GO:0042762)4.05378712
702-oxoglutarate metabolic process (GO:0006103)4.05127018
71response to muscle activity (GO:0014850)4.02527318
72respiratory electron transport chain (GO:0022904)3.99044756
73mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.97272817
74ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.96751688
75pyrimidine ribonucleoside catabolic process (GO:0046133)3.92878986
76NADH metabolic process (GO:0006734)3.88819558
77muscle system process (GO:0003012)3.88636509
78oxidative phosphorylation (GO:0006119)3.88412415
79regulation of sequestering of triglyceride (GO:0010889)3.87971934
80electron transport chain (GO:0022900)3.86907347
81polysaccharide catabolic process (GO:0000272)3.86237806
82striated muscle atrophy (GO:0014891)3.84509459
83glucan catabolic process (GO:0009251)3.82872797
84cell communication involved in cardiac conduction (GO:0086065)3.73697910
85regulation of calcium ion transmembrane transporter activity (GO:1901019)3.73468719
86regulation of calcium ion transmembrane transport (GO:1903169)3.73468719
87regulation of cardiac muscle cell contraction (GO:0086004)3.72976472
88energy coupled proton transport, down electrochemical gradient (GO:0015985)3.72673253
89ATP synthesis coupled proton transport (GO:0015986)3.72673253
90cardiac muscle adaptation (GO:0014887)3.72585380
91cardiac muscle hypertrophy in response to stress (GO:0014898)3.72585380
92muscle hypertrophy in response to stress (GO:0003299)3.72585380
93interkinetic nuclear migration (GO:0022027)3.64205430
94striated muscle cell development (GO:0055002)3.60980102
95positive regulation of cation channel activity (GO:2001259)3.60689397
96cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.59850622
97regulation of cardiac muscle contraction (GO:0055117)3.58603680
98response to activity (GO:0014823)3.58333920
99cytidine metabolic process (GO:0046087)3.58166213
100cytidine catabolic process (GO:0006216)3.58166213
101cytidine deamination (GO:0009972)3.58166213
102cellular polysaccharide catabolic process (GO:0044247)3.58072163
103regulation of the force of heart contraction (GO:0002026)3.57556862
104muscle cell cellular homeostasis (GO:0046716)3.48154889
105cardiac muscle cell action potential (GO:0086001)3.47585239
106cardiac muscle cell action potential involved in contraction (GO:0086002)3.46321153
107muscle adaptation (GO:0043500)3.45539552
108negative regulation of protein localization to cell surface (GO:2000009)3.44418433
109glucan biosynthetic process (GO:0009250)3.44090718
110glycogen biosynthetic process (GO:0005978)3.44090718
111succinate metabolic process (GO:0006105)3.43779498
112relaxation of cardiac muscle (GO:0055119)3.43571401
113muscle structure development (GO:0061061)3.40679061
114negative regulation of potassium ion transport (GO:0043267)3.38652164
115positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.38057162
116negative regulation of calcium ion transmembrane transport (GO:1903170)3.36482942
117negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.36482942
118negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.34311456
119muscle organ development (GO:0007517)3.32486044
120glycogen metabolic process (GO:0005977)3.30933943
121cellular glucan metabolic process (GO:0006073)3.23263598
122glucan metabolic process (GO:0044042)3.23263598
123regulation of ATP catabolic process (GO:1903289)3.22467046
124regulation of ATPase activity (GO:0043462)3.22467046
125regulation of skeletal muscle cell differentiation (GO:2001014)3.22230918
126regulation of muscle system process (GO:0090257)3.15577298
127negative regulation of necroptotic process (GO:0060546)3.06371690
128response to caffeine (GO:0031000)3.04040607
129regulation of muscle contraction (GO:0006937)3.03779051
130response to epinephrine (GO:0071871)3.00602867
131relaxation of muscle (GO:0090075)2.98775232
132striated muscle tissue development (GO:0014706)2.96594047

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.31065376
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.47651162
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.31009108
4EP300_21415370_ChIP-Seq_HL-1_Mouse4.25629499
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.13936084
6TBX20_22080862_ChIP-Seq_HEART_Mouse3.85389178
7TBX20_22328084_ChIP-Seq_HEART_Mouse3.85389178
8ESR1_20079471_ChIP-ChIP_T-47D_Human3.21822509
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.14501125
10IGF1R_20145208_ChIP-Seq_DFB_Human2.84958305
11MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.77299975
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.73450686
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61626541
14ZNF263_19887448_ChIP-Seq_K562_Human2.54183615
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.47183918
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.41812589
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.36443766
18GBX2_23144817_ChIP-Seq_PC3_Human2.35840877
19GATA4_21415370_ChIP-Seq_HL-1_Mouse2.19947398
20EZH2_22144423_ChIP-Seq_EOC_Human2.19251137
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08506430
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.05654403
23TAF15_26573619_Chip-Seq_HEK293_Human2.02476254
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.01453189
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00766718
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.98466794
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.93521326
28EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.89447247
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85269202
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.76459417
31EZH2_27294783_Chip-Seq_NPCs_Mouse1.74735494
32NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.73143668
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71003261
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64423656
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.63720614
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.61651100
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59968533
38CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.59815908
39ER_23166858_ChIP-Seq_MCF-7_Human1.58063343
40CRX_20693478_ChIP-Seq_RETINA_Mouse1.56092336
41CBP_20019798_ChIP-Seq_JUKART_Human1.53689377
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53689377
43BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.52738707
44VDR_22108803_ChIP-Seq_LS180_Human1.51564312
45BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.51059621
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.48251958
47PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.46728332
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46691007
49SMAD4_21799915_ChIP-Seq_A2780_Human1.45011214
50FUS_26573619_Chip-Seq_HEK293_Human1.44815927
51OCT4_21477851_ChIP-Seq_ESCs_Mouse1.43076507
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41376834
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.41332422
54SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.40253672
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.40073468
56CLOCK_20551151_ChIP-Seq_293T_Human1.37152945
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36207234
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35380974
59ZNF274_21170338_ChIP-Seq_K562_Hela1.32847211
60DROSHA_22980978_ChIP-Seq_HELA_Human1.31558265
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30563291
62STAT3_23295773_ChIP-Seq_U87_Human1.29541245
63TCF4_23295773_ChIP-Seq_U87_Human1.27223013
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27011623
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24030440
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23570861
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23406350
68CTCF_27219007_Chip-Seq_Bcells_Human1.23305219
69NANOG_19829295_ChIP-Seq_ESCs_Human1.23074540
70SOX2_19829295_ChIP-Seq_ESCs_Human1.23074540
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21891574
72GATA1_22025678_ChIP-Seq_K562_Human1.19341368
73* FLI1_21867929_ChIP-Seq_TH2_Mouse1.18131155
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17974913
75PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17187990
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16909895
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.15033374
78PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13016826
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11465192
80LXR_22158963_ChIP-Seq_LIVER_Mouse1.10881522
81* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10653931
82* HTT_18923047_ChIP-ChIP_STHdh_Human1.09391055
83P300_19829295_ChIP-Seq_ESCs_Human1.09330457
84P53_22387025_ChIP-Seq_ESCs_Mouse1.08648787
85RUNX_20019798_ChIP-Seq_JUKART_Human1.06433393
86PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05719940
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04939280
88OCT4_20526341_ChIP-Seq_ESCs_Human1.04914768
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04544605
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04281657
91NFYB_21822215_ChIP-Seq_K562_Human1.03657103
92AR_25329375_ChIP-Seq_VCAP_Human1.03436636
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03400943
94CDX2_22108803_ChIP-Seq_LS180_Human1.02609510
95* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01729692
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01377974
97KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01119531
98E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00828531
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00582771
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00420804
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.00109837
102AR_21572438_ChIP-Seq_LNCaP_Human0.99729904
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99714870
104PIAS1_25552417_ChIP-Seq_VCAP_Human0.99698787
105PHF8_20622853_ChIP-Seq_HELA_Human0.99528830
106RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99380055
107VDR_24787735_ChIP-Seq_THP-1_Human0.98613007
108* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97927457
109CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97467292
110CBX2_22325352_ChIP-Seq_293T-Rex_Human0.97339627
111ETV1_20927104_ChIP-Seq_GIST48_Human0.97323025
112CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97082405
113SALL1_21062744_ChIP-ChIP_HESCs_Human0.97005932
114AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96173881
115NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96102835
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95839079
117TBL1_22424771_ChIP-Seq_293T_Human0.95711868
118CJUN_26792858_Chip-Seq_BT549_Human0.94767990
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94754337
120KDM2B_26808549_Chip-Seq_DND41_Human0.94527972
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93972466
122P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93963825
123FOXH1_21741376_ChIP-Seq_ESCs_Human0.93859551
124TP63_22573176_ChIP-Seq_HFKS_Human0.93231603
125GATA2_21666600_ChIP-Seq_HMVEC_Human0.92991562
126BCAT_22108803_ChIP-Seq_LS180_Human0.92190260
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90931825
128RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90642399
129SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90600594
130CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90477221
131SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89550534
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88925026
133SOX2_21211035_ChIP-Seq_LN229_Gbm0.88629121
134NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88090182
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88090182
136SPI1_20517297_ChIP-Seq_HL60_Human0.87931791
137GATA1_19941826_ChIP-Seq_K562_Human0.87889465
138TDRD3_21172665_ChIP-Seq_MCF-7_Human0.86511744
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85670450
140TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83042005
141RXR_22158963_ChIP-Seq_LIVER_Mouse0.82966720
142P68_20966046_ChIP-Seq_HELA_Human0.79835662
143SMAD3_21741376_ChIP-Seq_HESCs_Human0.78710777
144CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78676782
145NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78598666
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.78372223
147GATA2_19941826_ChIP-Seq_K562_Human0.78247235
148ESR1_21235772_ChIP-Seq_MCF-7_Human0.78164089
149TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.77990845
150FOXA2_19822575_ChIP-Seq_HepG2_Human0.77465071
151GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77283344
152RUNX1_27514584_Chip-Seq_MCF-7_Human0.76743011
153MYC_27129775_Chip-Seq_CORNEA_Mouse0.76077185
154SMC1_22415368_ChIP-Seq_MEFs_Mouse0.75726590
155ISL1_27105846_Chip-Seq_CPCs_Mouse0.75422841
156GATA1_19941827_ChIP-Seq_MEL_Mouse0.73846942
157GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73070672
158STAT3_1855785_ChIP-Seq_MESCs_Mouse0.72011327
159ATF3_27146783_Chip-Seq_COLON_Human0.71859536
160KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.71557933
161HIF1A_21447827_ChIP-Seq_MCF-7_Human0.71138624
162SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.70697776
163P63_26484246_Chip-Seq_KERATINOCYTES_Human0.69704968
164DNAJC2_21179169_ChIP-ChIP_NT2_Human0.69295092
165SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.68780690
166EZH2_27294783_Chip-Seq_ESCs_Mouse0.68361039
167EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.68151448
168MTF2_20144788_ChIP-Seq_MESCs_Mouse0.67544383
169JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67090920
170RACK7_27058665_Chip-Seq_MCF-7_Human0.67001868
171YY1_22570637_ChIP-Seq_MALME-3M_Human0.66884726
172SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66726516
173CTCF_21964334_Chip-Seq_Bcells_Human0.66564240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.59578561
2MP0002837_dystrophic_cardiac_calcinosis6.06447627
3MP0000751_myopathy5.53829399
4MP0000749_muscle_degeneration4.80010406
5MP0004084_abnormal_cardiac_muscle4.58470150
6MP0004036_abnormal_muscle_relaxation4.32236609
7MP0004145_abnormal_muscle_electrophysio4.22771588
8MP0004215_abnormal_myocardial_fiber4.05821960
9MP0005330_cardiomyopathy3.46755360
10MP0004087_abnormal_muscle_fiber3.28132573
11MP0002106_abnormal_muscle_physiology3.18273429
12MP0004130_abnormal_muscle_cell3.17987045
13MP0000750_abnormal_muscle_regeneration2.98184227
14MP0005620_abnormal_muscle_contractility2.92881758
15MP0002269_muscular_atrophy2.82236680
16MP0000747_muscle_weakness2.76384000
17MP0002972_abnormal_cardiac_muscle2.66500507
18MP0000759_abnormal_skeletal_muscle2.63761095
19MP0005369_muscle_phenotype2.60448886
20MP0008775_abnormal_heart_ventricle2.48435666
21MP0004484_altered_response_of2.48152920
22MP0003137_abnormal_impulse_conducting2.40887423
23MP0010630_abnormal_cardiac_muscle2.27060936
24MP0001544_abnormal_cardiovascular_syste2.23868885
25MP0005385_cardiovascular_system_phenoty2.23868885
26MP0004233_abnormal_muscle_weight2.14188570
27MP0006036_abnormal_mitochondrial_physio2.01090337
28MP0002332_abnormal_exercise_endurance1.87032682
29MP0003221_abnormal_cardiomyocyte_apopto1.84432596
30MP0006138_congestive_heart_failure1.81473928
31MP0003828_pulmonary_edema1.78315447
32MP0004085_abnormal_heartbeat1.71459168
33MP0005666_abnormal_adipose_tissue1.60757908
34MP0004510_myositis1.54315348
35MP0002127_abnormal_cardiovascular_syste1.43014331
36MP0003950_abnormal_plasma_membrane1.37824904
37MP0004185_abnormal_adipocyte_glucose1.35495805
38MP0002108_abnormal_muscle_morphology1.24770252
39MP0005670_abnormal_white_adipose1.19634952
40MP0006035_abnormal_mitochondrial_morpho1.18638890
41MP0000372_irregular_coat_pigmentation1.16537404
42MP0000343_altered_response_to1.13656044
43MP0005375_adipose_tissue_phenotype1.07085133
44MP0001661_extended_life_span1.06605801
45MP0000266_abnormal_heart_morphology1.01288721
46MP0000733_abnormal_muscle_development1.00813035
47MP0003567_abnormal_fetal_cardiomyocyte1.00795275
48MP0005266_abnormal_metabolism0.96118804
49MP0005165_increased_susceptibility_to0.91740662
50MP0002234_abnormal_pharynx_morphology0.91329903
51MP0002971_abnormal_brown_adipose0.88893805
52MP0004043_abnormal_pH_regulation0.84194242
53MP0003806_abnormal_nucleotide_metabolis0.73416518
54MP0000230_abnormal_systemic_arterial0.72712895
55MP0004147_increased_porphyrin_level0.70605669
56MP0009780_abnormal_chondrocyte_physiolo0.68195811
57MP0010368_abnormal_lymphatic_system0.64525956
58MP0002078_abnormal_glucose_homeostasis0.60662046
59MP0002128_abnormal_blood_circulation0.60261139
60MP0000013_abnormal_adipose_tissue0.59345942
61MP0005623_abnormal_meninges_morphology0.59043166
62MP0005645_abnormal_hypothalamus_physiol0.55933923
63MP0001879_abnormal_lymphatic_vessel0.55271852
64MP0000003_abnormal_adipose_tissue0.55082364
65MP0003279_aneurysm0.54934558
66MP0004142_abnormal_muscle_tone0.51778296
67MP0008961_abnormal_basal_metabolism0.50741839
68MP0002822_catalepsy0.49590763
69MP0002638_abnormal_pupillary_reflex0.49053512
70MP0002876_abnormal_thyroid_physiology0.47625702
71MP0001986_abnormal_taste_sensitivity0.47496183
72MP0005319_abnormal_enzyme/_coenzyme0.45632390
73MP0003879_abnormal_hair_cell0.45600462
74MP0002909_abnormal_adrenal_gland0.44271416
75MP0005535_abnormal_body_temperature0.43478215
76MP0005334_abnormal_fat_pad0.42423096
77MP0003656_abnormal_erythrocyte_physiolo0.42321302
78MP0004134_abnormal_chest_morphology0.42307914
79MP0005187_abnormal_penis_morphology0.41100898
80MP0003195_calcinosis0.40496362
81MP0003566_abnormal_cell_adhesion0.40349309
82MP0001984_abnormal_olfaction0.39636354
83MP0003045_fibrosis0.39146230
84MP0005083_abnormal_biliary_tract0.38356232
85MP0005423_abnormal_somatic_nervous0.37600409
86MP0006276_abnormal_autonomic_nervous0.37324304
87MP0003705_abnormal_hypodermis_morpholog0.36857654
88MP0000767_abnormal_smooth_muscle0.35267926
89MP0002925_abnormal_cardiovascular_devel0.33353453
90MP0005584_abnormal_enzyme/coenzyme_acti0.32830199
91MP0001440_abnormal_grooming_behavior0.31716718
92MP0003948_abnormal_gas_homeostasis0.31407139
93MP0001853_heart_inflammation0.30056208
94MP0009115_abnormal_fat_cell0.28510923
95MP0002163_abnormal_gland_morphology0.28188003
96MP0002118_abnormal_lipid_homeostasis0.28165714
97MP0008995_early_reproductive_senescence0.27424213
98MP0001501_abnormal_sleep_pattern0.26910304
99MP0000569_abnormal_digit_pigmentation0.26875292
100MP0005452_abnormal_adipose_tissue0.26645737
101MP0002009_preneoplasia0.25534936
102MP0008057_abnormal_DNA_replication0.25417662
103MP0005166_decreased_susceptibility_to0.24821351
104MP0001614_abnormal_blood_vessel0.24641372
105MP0008569_lethality_at_weaning0.23971766
106MP0005253_abnormal_eye_physiology0.23081938
107MP0005451_abnormal_body_composition0.22370720
108MP0001727_abnormal_embryo_implantation0.22107418
109MP0001502_abnormal_circadian_rhythm0.21949812
110MP0002067_abnormal_sensory_capabilities0.21694215
111MP0005386_behavior/neurological_phenoty0.21526810
112MP0004924_abnormal_behavior0.21526810
113MP0001485_abnormal_pinna_reflex0.21324380
114MP0005167_abnormal_blood-brain_barrier0.21114958
115MP0001299_abnormal_eye_distance/0.20817805
116MP0005275_abnormal_skin_tensile0.20092187
117MP0005376_homeostasis/metabolism_phenot0.19967673
118MP0001784_abnormal_fluid_regulation0.19909433
119MP0000249_abnormal_blood_vessel0.18195388
120MP0004270_analgesia0.17924488
121MP0009840_abnormal_foam_cell0.17289077
122MP0008874_decreased_physiological_sensi0.16300423
123MP0005332_abnormal_amino_acid0.14862391
124MP0002970_abnormal_white_adipose0.14630206
125MP0003959_abnormal_lean_body0.13342131

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)7.67804309
2Exercise-induced muscle cramps (HP:0003710)7.39955453
3Muscle hypertrophy of the lower extremities (HP:0008968)7.13287952
4Calf muscle hypertrophy (HP:0008981)7.08242751
5Sudden death (HP:0001699)6.39767101
6Myoglobinuria (HP:0002913)5.88011105
7Muscle fiber splitting (HP:0003555)5.73139458
8Ventricular tachycardia (HP:0004756)5.59230008
9Muscle fiber inclusion bodies (HP:0100299)5.32554478
10Abnormality of the calf musculature (HP:0001430)5.25282920
11Hyporeflexia of lower limbs (HP:0002600)5.21288344
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.14063046
13Difficulty running (HP:0009046)4.75509831
14Atrial fibrillation (HP:0005110)4.65439144
15Rhabdomyolysis (HP:0003201)4.63654950
16EMG: myopathic abnormalities (HP:0003458)4.51612958
17Nemaline bodies (HP:0003798)4.47332362
18Subaortic stenosis (HP:0001682)4.45595058
19Abnormality of the left ventricular outflow tract (HP:0011103)4.45595058
20Primary atrial arrhythmia (HP:0001692)4.34322241
21Increased connective tissue (HP:0009025)4.27441055
22Lipoatrophy (HP:0100578)4.19883807
23Supraventricular tachycardia (HP:0004755)4.18489247
24Supraventricular arrhythmia (HP:0005115)4.08327048
25Centrally nucleated skeletal muscle fibers (HP:0003687)4.06034034
26Myotonia (HP:0002486)4.05346851
27Bundle branch block (HP:0011710)3.90604548
28Asymmetric septal hypertrophy (HP:0001670)3.89028552
29Type 1 muscle fiber predominance (HP:0003803)3.87451358
30Muscle stiffness (HP:0003552)3.81883787
31Right ventricular cardiomyopathy (HP:0011663)3.81608233
32Palpitations (HP:0001962)3.70355211
33Syncope (HP:0001279)3.64392371
34Dilated cardiomyopathy (HP:0001644)3.64231624
35Prolonged QT interval (HP:0001657)3.30826611
36Distal arthrogryposis (HP:0005684)3.29230729
37Difficulty climbing stairs (HP:0003551)3.28630213
38Myopathic facies (HP:0002058)3.24777317
39Heart block (HP:0012722)3.21202441
40Ventricular arrhythmia (HP:0004308)3.15430704
41Malignant hyperthermia (HP:0002047)3.03027308
42Abnormal atrioventricular conduction (HP:0005150)3.02005927
43Areflexia of lower limbs (HP:0002522)3.01830286
44Round ear (HP:0100830)2.97702393
45Increased variability in muscle fiber diameter (HP:0003557)2.95372566
46Distal lower limb muscle weakness (HP:0009053)2.94872456
47Abnormality of skeletal muscle fiber size (HP:0012084)2.94618303
48Atrioventricular block (HP:0001678)2.85767837
49Abnormal finger flexion creases (HP:0006143)2.83579150
50Abnormal mitochondria in muscle tissue (HP:0008316)2.79298013
51Acute necrotizing encephalopathy (HP:0006965)2.75000813
52Rimmed vacuoles (HP:0003805)2.72981157
53Neck muscle weakness (HP:0000467)2.71720227
54Ulnar deviation of the wrist (HP:0003049)2.61532879
55Hepatic necrosis (HP:0002605)2.59925262
56Ventricular fibrillation (HP:0001663)2.59043628
57Ketoacidosis (HP:0001993)2.56568939
58Left ventricular hypertrophy (HP:0001712)2.55132206
59Limb-girdle muscle atrophy (HP:0003797)2.45056855
60Abnormal EKG (HP:0003115)2.40239544
61Acute encephalopathy (HP:0006846)2.37158507
62Hypoplastic ischia (HP:0003175)2.35580953
63Fetal akinesia sequence (HP:0001989)2.33610389
64Hypoglycemic coma (HP:0001325)2.33441514
65Progressive macrocephaly (HP:0004481)2.30067364
66Increased muscle lipid content (HP:0009058)2.29293371
67Muscular dystrophy (HP:0003560)2.28333263
68Weak cry (HP:0001612)2.26691800
69Exercise intolerance (HP:0003546)2.26312589
70Long clavicles (HP:0000890)2.24098758
71Abnormality of alanine metabolism (HP:0010916)2.24003303
72Hyperalaninemia (HP:0003348)2.24003303
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24003303
74Hepatocellular necrosis (HP:0001404)2.22934108
75Bulbar palsy (HP:0001283)2.20503308
76Facial diplegia (HP:0001349)2.18444847
77Cerebral edema (HP:0002181)2.18117412
78Mitochondrial inheritance (HP:0001427)2.16498661
79Abnormality of dicarboxylic acid metabolism (HP:0010995)2.13348661
80Dicarboxylic aciduria (HP:0003215)2.13348661
81Mildly elevated creatine phosphokinase (HP:0008180)2.10663711
82Distal lower limb amyotrophy (HP:0008944)2.09926109
83Abnormality of fatty-acid metabolism (HP:0004359)2.08642743
84Increased CSF lactate (HP:0002490)2.07283767
85Slender build (HP:0001533)2.07010930
86EMG: neuropathic changes (HP:0003445)2.06651770
87Frequent falls (HP:0002359)2.05991994
88Proximal amyotrophy (HP:0007126)2.05964964
89Gowers sign (HP:0003391)2.05531762
90Abnormality of the ischium (HP:0003174)2.04719195
91Increased intramyocellular lipid droplets (HP:0012240)2.04352664
92Calcaneovalgus deformity (HP:0001848)2.03882567
93Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.03432541
94Testicular atrophy (HP:0000029)2.03393855
95Palmoplantar keratoderma (HP:0000982)2.03276184
96Absent phalangeal crease (HP:0006109)2.03114007
97Generalized muscle weakness (HP:0003324)2.02892099
98Fatigable weakness (HP:0003473)2.01269027
99Abnormality of the neuromuscular junction (HP:0003398)2.01269027
100Pheochromocytoma (HP:0002666)1.97693927
101Lactic acidosis (HP:0003128)1.96859327
102Conjunctival hamartoma (HP:0100780)1.96789743
103Ketosis (HP:0001946)1.95122158
104Hip contracture (HP:0003273)1.93529736
105Progressive muscle weakness (HP:0003323)1.91059153
106Limb-girdle muscle weakness (HP:0003325)1.89598187
107Hyperkalemia (HP:0002153)1.87992038
108Toxemia of pregnancy (HP:0100603)1.87104383
109Neoplasm of head and neck (HP:0012288)1.83354259
110Esophageal neoplasm (HP:0100751)1.83354259
111Abnormality of the shoulder girdle musculature (HP:0001435)1.82513433
112Scapular winging (HP:0003691)1.81615110
113Abnormality of the foot musculature (HP:0001436)1.81433977
114Deformed tarsal bones (HP:0008119)1.79485036
115Waddling gait (HP:0002515)1.79005793
116Nonprogressive disorder (HP:0003680)1.76319565
117Abnormality of the hip-girdle musculature (HP:0001445)1.72864710
118Abnormality of the musculature of the pelvis (HP:0001469)1.72864710
119Abnormality of the calcaneus (HP:0008364)1.72603699
120Respiratory insufficiency due to muscle weakness (HP:0002747)1.68062298
121Insulin-resistant diabetes mellitus (HP:0000831)1.67691411
122Spinal rigidity (HP:0003306)1.66497611
123Paralysis (HP:0003470)1.65706816
124Foot dorsiflexor weakness (HP:0009027)1.63686996
125Pelvic girdle muscle weakness (HP:0003749)1.60376937
126Ragged-red muscle fibers (HP:0003200)1.53697926
127Type 2 muscle fiber atrophy (HP:0003554)1.53249640
128Popliteal pterygium (HP:0009756)1.52442857
129Shoulder girdle muscle weakness (HP:0003547)1.52086871
130Oligomenorrhea (HP:0000876)1.50671539
131Steppage gait (HP:0003376)1.41960517

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.90053336
2OBSCN5.60955298
3PHKG15.08048347
4PHKG25.08048347
5PDK43.56853972
6PDK33.56853972
7LMTK22.70951884
8DMPK2.70356002
9BCKDK2.55484636
10PINK12.49502807
11PDK22.33487169
12NEK12.32180137
13MYLK2.26311042
14TRIB32.14462283
15PKN22.13068321
16PIK3CA2.06546254
17MUSK1.89846356
18MAP2K31.74076430
19FRK1.73393985
20NME11.66268159
21GRK71.53842204
22MAP3K71.53411425
23STK241.47183344
24TIE11.40460620
25MAPK121.27449829
26PIK3CG1.19532105
27AKT31.15651741
28INSRR1.13898984
29CAMK2D1.04672223
30PRKAA20.97640888
31PRKD10.96482900
32PAK30.95374512
33PRKAA10.95168856
34ZAK0.94453698
35TRPM70.93773871
36MARK10.92283688
37CCNB10.90349052
38RIPK10.85629993
39BMPR1B0.80358697
40NEK90.79973349
41TAOK30.79243873
42STK160.75335283
43ILK0.74204960
44MAPK130.73626563
45PKN10.70573433
46MAP2K40.70330261
47MAP3K30.69879669
48ROCK10.67227235
49DYRK1B0.61871886
50CAMK40.61011513
51FLT30.57919313
52MAPKAPK30.57308353
53MAP2K60.56458768
54ACVR1B0.55729553
55MAP3K50.54293559
56TBK10.53490086
57NLK0.52763590
58CAMK2G0.50972168
59MAP4K20.50303780
60WNK40.49684735
61MAP3K130.49070882
62STK38L0.49021814
63STK40.48155986
64MAPK40.47332356
65EPHB10.45871121
66MAPK110.45196578
67CAMK2A0.44952593
68MAP3K40.44006684
69WNK10.43555837
70PRKACB0.43237744
71CDC42BPA0.43005485
72EEF2K0.41669951
73STK380.41057483
74STK110.40912190
75TNIK0.38111856
76AKT20.37140569
77CAMK10.36763466
78TGFBR20.36303750
79PRKACA0.36097028
80RPS6KL10.35243405
81RPS6KC10.35243405
82ROCK20.34842730
83PDGFRA0.34760020
84NME20.34356773
85KDR0.34349040
86OXSR10.34254110
87BLK0.33775765
88TNK20.33726457
89PDPK10.33512710
90RPS6KB10.33123020
91SGK2230.33106252
92SGK4940.33106252
93MOS0.32977226
94PRKACG0.32473409
95MARK20.31079751
96MAP3K60.30961624
97PDK10.29575965
98DAPK30.28958464
99PTK2B0.28141031
100RPS6KA60.27631839
101TYK20.27615207
102SGK30.27568244
103SIK10.26961746
104TAOK20.26959991
105SGK10.26105062
106PTK60.25686470
107CAMK2B0.25128232
108EIF2AK30.24959374
109TAOK10.24044911
110MAP2K10.24033615
111RPS6KA10.24003241
112MAPK100.23366555
113TEC0.23009288
114MAPK150.22457992
115PRKCE0.22255883
116PRKD30.21908668
117PRKG10.21780949
118MARK30.21062185
119PRKCH0.21034644
120RPS6KA30.20088484
121ERBB30.19282728
122EPHA30.18448534
123MAP3K120.17485703
124SYK0.17484264
125MAPK70.16756459
126JAK10.16671920
127CAMKK20.16004443
128ZAP700.15976115
129MAPK80.14027486
130ICK0.13884437
131ADRBK10.11699619
132IKBKB0.11467026
133MAPKAPK50.10799731
134STK390.10376143
135RPS6KA20.10251513
136MAP3K10.09679939
137MAP3K110.09422845
138MTOR0.09166042
139JAK20.07605202
140PRKCQ0.07559663
141SGK20.06480753
142RET0.06220961
143PAK60.06093399
144FER0.05414358

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.88762025
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.14314303
3Cardiac muscle contraction_Homo sapiens_hsa042604.00263625
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.64240168
5Dilated cardiomyopathy_Homo sapiens_hsa054143.53396908
6Propanoate metabolism_Homo sapiens_hsa006403.46731364
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.07236757
8Parkinsons disease_Homo sapiens_hsa050123.02115953
9Oxidative phosphorylation_Homo sapiens_hsa001902.93715736
10Fatty acid degradation_Homo sapiens_hsa000712.77140782
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.73803028
12Carbon metabolism_Homo sapiens_hsa012002.46953966
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41920586
14Alzheimers disease_Homo sapiens_hsa050102.36761006
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.18491534
16Fatty acid metabolism_Homo sapiens_hsa012122.09686052
17Huntingtons disease_Homo sapiens_hsa050161.84777657
18Pyruvate metabolism_Homo sapiens_hsa006201.79531395
19Viral myocarditis_Homo sapiens_hsa054161.65051457
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59455852
21Nitrogen metabolism_Homo sapiens_hsa009101.52781638
22Starch and sucrose metabolism_Homo sapiens_hsa005001.44060341
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37984657
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37634835
25Butanoate metabolism_Homo sapiens_hsa006501.36952485
26Glucagon signaling pathway_Homo sapiens_hsa049221.32956025
27Insulin resistance_Homo sapiens_hsa049311.32031391
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26215400
29Regulation of autophagy_Homo sapiens_hsa041401.24371656
30Insulin signaling pathway_Homo sapiens_hsa049101.20227391
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.20214612
32Fatty acid elongation_Homo sapiens_hsa000621.12061141
33Biosynthesis of amino acids_Homo sapiens_hsa012301.07792402
34Calcium signaling pathway_Homo sapiens_hsa040201.04681987
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04369924
36Oxytocin signaling pathway_Homo sapiens_hsa049211.02581378
37PPAR signaling pathway_Homo sapiens_hsa033200.94375307
38Circadian rhythm_Homo sapiens_hsa047100.92986360
39AMPK signaling pathway_Homo sapiens_hsa041520.90932188
40Arginine and proline metabolism_Homo sapiens_hsa003300.84801271
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84376454
42Galactose metabolism_Homo sapiens_hsa000520.76745885
43beta-Alanine metabolism_Homo sapiens_hsa004100.74780161
44Tryptophan metabolism_Homo sapiens_hsa003800.72786411
45HIF-1 signaling pathway_Homo sapiens_hsa040660.70582565
46Fructose and mannose metabolism_Homo sapiens_hsa000510.70104470
47Arginine biosynthesis_Homo sapiens_hsa002200.70102387
48Lysine degradation_Homo sapiens_hsa003100.68259649
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.67831332
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67730542
51Long-term potentiation_Homo sapiens_hsa047200.67012409
52Fatty acid biosynthesis_Homo sapiens_hsa000610.62124725
53Focal adhesion_Homo sapiens_hsa045100.61965436
54Olfactory transduction_Homo sapiens_hsa047400.61830429
55Type II diabetes mellitus_Homo sapiens_hsa049300.61703467
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60106313
57Salivary secretion_Homo sapiens_hsa049700.57044635
58Long-term depression_Homo sapiens_hsa047300.56231066
59Amphetamine addiction_Homo sapiens_hsa050310.55282377
60Peroxisome_Homo sapiens_hsa041460.55068021
61Gastric acid secretion_Homo sapiens_hsa049710.50193303
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49974647
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.48931059
64Renin secretion_Homo sapiens_hsa049240.48138850
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48133303
66Tight junction_Homo sapiens_hsa045300.47005244
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44689771
68Insulin secretion_Homo sapiens_hsa049110.42538326
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42164642
70Phenylalanine metabolism_Homo sapiens_hsa003600.37408355
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37265228
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36976109
73Purine metabolism_Homo sapiens_hsa002300.35015035
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34388002
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33888015
76cAMP signaling pathway_Homo sapiens_hsa040240.32508831
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.31995753
78Inositol phosphate metabolism_Homo sapiens_hsa005620.29304645
79GnRH signaling pathway_Homo sapiens_hsa049120.27327192
80B cell receptor signaling pathway_Homo sapiens_hsa046620.27060954
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26466901
82FoxO signaling pathway_Homo sapiens_hsa040680.24746801
83VEGF signaling pathway_Homo sapiens_hsa043700.24682123
84Metabolic pathways_Homo sapiens_hsa011000.23878148
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.22614147
86Amoebiasis_Homo sapiens_hsa051460.22251698
87Circadian entrainment_Homo sapiens_hsa047130.21743663
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20875178
89Renal cell carcinoma_Homo sapiens_hsa052110.20463330
90Adherens junction_Homo sapiens_hsa045200.20377103
91Platelet activation_Homo sapiens_hsa046110.18977402
92Phototransduction_Homo sapiens_hsa047440.18854092
93mTOR signaling pathway_Homo sapiens_hsa041500.17686064
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.16419842
95MAPK signaling pathway_Homo sapiens_hsa040100.16248675
96Taste transduction_Homo sapiens_hsa047420.15302295
97ECM-receptor interaction_Homo sapiens_hsa045120.15091275
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15080597
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.14434589
100Cholinergic synapse_Homo sapiens_hsa047250.14336793
101Pancreatic secretion_Homo sapiens_hsa049720.14125931
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.14078026
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12529365
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.11689123
105Fat digestion and absorption_Homo sapiens_hsa049750.11377289
106Pentose phosphate pathway_Homo sapiens_hsa000300.11184916
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.10978630
108Proteoglycans in cancer_Homo sapiens_hsa052050.10436549
109Serotonergic synapse_Homo sapiens_hsa047260.10190988
110Dorso-ventral axis formation_Homo sapiens_hsa043200.10009243
111Gap junction_Homo sapiens_hsa045400.06671788
112Tyrosine metabolism_Homo sapiens_hsa003500.05459684
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.04835060
114Ovarian steroidogenesis_Homo sapiens_hsa049130.03965879
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.03143420
116Toxoplasmosis_Homo sapiens_hsa051450.00717268
117Linoleic acid metabolism_Homo sapiens_hsa00591-0.0650034
118Bile secretion_Homo sapiens_hsa04976-0.0276204
119ABC transporters_Homo sapiens_hsa02010-0.0262397
120Osteoclast differentiation_Homo sapiens_hsa04380-0.0255580
121Salmonella infection_Homo sapiens_hsa05132-0.0188605
122Glycerolipid metabolism_Homo sapiens_hsa00561-0.0082179
123alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0042705

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