ASB16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-mediated cell contraction (GO:0070252)9.70919920
2sarcoplasmic reticulum calcium ion transport (GO:0070296)9.63138780
3skeletal muscle adaptation (GO:0043501)9.19118659
4skeletal muscle fiber development (GO:0048741)7.63756946
5plasma membrane repair (GO:0001778)7.25690111
6actin filament-based movement (GO:0030048)7.12668117
7skeletal muscle tissue regeneration (GO:0043403)6.71266704
8purine nucleotide salvage (GO:0032261)6.57838455
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.48024011
10myotube cell development (GO:0014904)6.38358442
11striated muscle contraction (GO:0006941)6.23555831
12glycogen catabolic process (GO:0005980)6.16580739
13IMP metabolic process (GO:0046040)6.10873805
14sarcomere organization (GO:0045214)6.06761460
15creatine metabolic process (GO:0006600)6.02728792
16response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.90455097
17pyrimidine ribonucleoside catabolic process (GO:0046133)5.78982578
18glucan catabolic process (GO:0009251)5.75225684
19cytidine deamination (GO:0009972)5.50967295
20cytidine metabolic process (GO:0046087)5.50967295
21cytidine catabolic process (GO:0006216)5.50967295
22myofibril assembly (GO:0030239)5.36651521
23IMP biosynthetic process (GO:0006188)5.34418504
24cellular polysaccharide catabolic process (GO:0044247)5.34221847
25striated muscle atrophy (GO:0014891)5.33111755
26response to muscle activity (GO:0014850)5.31706270
27carnitine shuttle (GO:0006853)5.29104367
28muscle contraction (GO:0006936)5.17929063
29polysaccharide catabolic process (GO:0000272)5.13728895
30striated muscle adaptation (GO:0014888)4.98194310
31regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.97254996
32negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.90122055
33response to inactivity (GO:0014854)4.77960619
34regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.70893924
35behavioral response to nicotine (GO:0035095)4.69281596
36glycogen biosynthetic process (GO:0005978)4.62617743
37glucan biosynthetic process (GO:0009250)4.62617743
38regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.61762890
39muscle system process (GO:0003012)4.56573259
40muscle fiber development (GO:0048747)4.53488347
41muscle atrophy (GO:0014889)4.43833855
42regulation of cell communication by electrical coupling (GO:0010649)4.38450961
43fatty acid transmembrane transport (GO:1902001)4.27418725
442-oxoglutarate metabolic process (GO:0006103)4.23248537
45actomyosin structure organization (GO:0031032)4.18325641
46regulation of acyl-CoA biosynthetic process (GO:0050812)4.15873080
47negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.15469540
48neuronal action potential propagation (GO:0019227)4.12432997
49carnitine transmembrane transport (GO:1902603)4.06751404
50glycogen metabolic process (GO:0005977)4.00650375
51muscle cell cellular homeostasis (GO:0046716)3.94721376
52glucan metabolic process (GO:0044042)3.91952061
53cellular glucan metabolic process (GO:0006073)3.91952061
54negative regulation of cAMP-mediated signaling (GO:0043951)3.87590492
55muscle adaptation (GO:0043500)3.85736159
56negative regulation of muscle hypertrophy (GO:0014741)3.83794011
57regulation of coenzyme metabolic process (GO:0051196)3.80777230
58regulation of cofactor metabolic process (GO:0051193)3.80777230
59DNA double-strand break processing (GO:0000729)3.70712652
60regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.69234894
61positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.67940716
62negative regulation of potassium ion transmembrane transport (GO:1901380)3.66744034
63striated muscle cell development (GO:0055002)3.66379256
64carnitine transport (GO:0015879)3.64665958
65amino-acid betaine transport (GO:0015838)3.64665958
66response to activity (GO:0014823)3.64636039
67tricarboxylic acid cycle (GO:0006099)3.60737158
68mannosylation (GO:0097502)3.58646522
69ubiquinone biosynthetic process (GO:0006744)3.57896671
70muscle organ development (GO:0007517)3.56639434
71cardiac muscle contraction (GO:0060048)3.53753852
72regulation of sequestering of triglyceride (GO:0010889)3.52591847
73muscle structure development (GO:0061061)3.51281920
74cellular carbohydrate catabolic process (GO:0044275)3.48376547
75nucleotide salvage (GO:0043173)3.42105714
76cellular response to dexamethasone stimulus (GO:0071549)3.41961610
77regulation of skeletal muscle cell differentiation (GO:2001014)3.39541416
78synaptic transmission, cholinergic (GO:0007271)3.37842722
79glyoxylate metabolic process (GO:0046487)3.36907807
80protein hydroxylation (GO:0018126)3.33768697
81cardiac muscle cell development (GO:0055013)3.31929548
82neuromuscular synaptic transmission (GO:0007274)3.30842960
83regulation of memory T cell differentiation (GO:0043380)3.29705265
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.28155773
85interkinetic nuclear migration (GO:0022027)3.26426493
86negative regulation of skeletal muscle tissue development (GO:0048642)3.25542646
87negative regulation of calcium ion transport into cytosol (GO:0010523)3.24999569
88NADH metabolic process (GO:0006734)3.23242382
89skeletal muscle tissue development (GO:0007519)3.15751254
90response to dexamethasone (GO:0071548)3.14552896
91histone H3 deacetylation (GO:0070932)3.12595966
92histone H4 deacetylation (GO:0070933)3.11519022
93myotube differentiation (GO:0014902)3.11470932
94muscle cell development (GO:0055001)3.09928357
95ubiquinone metabolic process (GO:0006743)3.09529772
96muscle cell fate commitment (GO:0042693)3.08153732
97regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.07168744
98positive regulation of myotube differentiation (GO:0010831)3.06431679
99cardiac cell development (GO:0055006)3.02774148
100regulation of sulfur metabolic process (GO:0042762)2.99310426
101positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.96129571
102regulation of relaxation of muscle (GO:1901077)2.96035564
103heart contraction (GO:0060047)2.93418921
104heart process (GO:0003015)2.93418921
105succinate metabolic process (GO:0006105)2.90981364
106DNA deamination (GO:0045006)2.88821914
107AMP metabolic process (GO:0046033)2.87964020
108cardiac myofibril assembly (GO:0055003)2.87825513
109regulation of glucokinase activity (GO:0033131)2.87498750
110regulation of hexokinase activity (GO:1903299)2.87498750
111myoblast fusion (GO:0007520)2.87220855
112amino acid salvage (GO:0043102)2.86520875
113L-methionine salvage (GO:0071267)2.86520875
114L-methionine biosynthetic process (GO:0071265)2.86520875
115arginine catabolic process (GO:0006527)2.84820212
116cellular polysaccharide metabolic process (GO:0044264)2.83586146
117purine-containing compound salvage (GO:0043101)2.83047465
118cellular polysaccharide biosynthetic process (GO:0033692)2.82701094
119polysaccharide biosynthetic process (GO:0000271)2.82322385
120regulation of calcium ion transmembrane transporter activity (GO:1901019)2.81020066
121positive regulation of sodium ion transmembrane transport (GO:1902307)2.79263337
122regulation of striated muscle contraction (GO:0006942)2.78761628
123regulation of gamma-delta T cell differentiation (GO:0045586)2.77456582
124positive regulation by host of viral transcription (GO:0043923)2.76716689
125macroautophagy (GO:0016236)2.75516978
126preassembly of GPI anchor in ER membrane (GO:0016254)2.73793836
127positive regulation of protein kinase C signaling (GO:0090037)2.73715914
128quinone biosynthetic process (GO:1901663)2.73548061
129positive regulation of cation channel activity (GO:2001259)2.72136111
130protein ADP-ribosylation (GO:0006471)2.71424021
131regulation of actin filament-based movement (GO:1903115)2.69494243
132negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.69077382
133negative regulation of cell killing (GO:0031342)2.69077382
134protein-cofactor linkage (GO:0018065)2.68802640
135muscle organ morphogenesis (GO:0048644)2.66011639
136valine metabolic process (GO:0006573)2.64856133
137Peyers patch development (GO:0048541)2.63985590
138mucosal-associated lymphoid tissue development (GO:0048537)2.63985590
139pyrimidine nucleoside catabolic process (GO:0046135)2.62192574
140DNA methylation involved in gamete generation (GO:0043046)2.61689874
141mitochondrial calcium ion homeostasis (GO:0051560)2.60714720
142negative regulation of potassium ion transport (GO:0043267)2.59838024
143mitochondrial genome maintenance (GO:0000002)2.57743292
144positive regulation of defense response to virus by host (GO:0002230)2.55457496
145negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.52451018
146purinergic nucleotide receptor signaling pathway (GO:0035590)2.48650685
147adult heart development (GO:0007512)2.47678757
148negative regulation of reactive oxygen species metabolic process (GO:2000378)2.45190930
149actin-myosin filament sliding (GO:0033275)11.9896885
150muscle filament sliding (GO:0030049)11.9896885
151regulation of skeletal muscle contraction (GO:0014819)11.4883361
152skeletal muscle contraction (GO:0003009)10.7209122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.86606533
2ZNF263_19887448_ChIP-Seq_K562_Human3.60492767
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.44970442
4EZH2_22144423_ChIP-Seq_EOC_Human3.40818325
5BCL3_23251550_ChIP-Seq_MUSCLE_Mouse3.18004341
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.17706609
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.17423168
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.01884236
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.80623572
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.53545598
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.50308230
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.48475160
13LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.37981499
14* BCL6_27268052_Chip-Seq_Bcells_Human2.25364698
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.14817310
16EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.02790874
17* STAT3_1855785_ChIP-Seq_MESCs_Mouse2.00542063
18DROSHA_22980978_ChIP-Seq_HELA_Human1.95674007
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.92455023
20* NANOG_20526341_ChIP-Seq_ESCs_Human1.91063140
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.90311467
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89949514
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89704655
24* BCOR_27268052_Chip-Seq_Bcells_Human1.87548232
25* OCT4_20526341_ChIP-Seq_ESCs_Human1.86505987
26CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.86274964
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.81032422
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.81032422
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.81032422
30* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.80199561
31* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.77477251
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.77025909
33PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.76858265
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76699221
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74497278
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.72166261
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63992772
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62496959
39RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.62434699
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.59474715
41PHF8_20622854_ChIP-Seq_HELA_Human1.58258855
42TBX20_22080862_ChIP-Seq_HEART_Mouse1.56786794
43TBX20_22328084_ChIP-Seq_HEART_Mouse1.56786794
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55574802
45SA1_27219007_Chip-Seq_Bcells_Human1.55006200
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54874594
47IGF1R_20145208_ChIP-Seq_DFB_Human1.54790865
48RARB_24833708_ChIP-Seq_LIVER_Mouse1.54486200
49P53_21459846_ChIP-Seq_SAOS-2_Human1.50462882
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49663839
51TAF2_19829295_ChIP-Seq_ESCs_Human1.49209630
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47832170
53ATF3_27146783_Chip-Seq_COLON_Human1.47665382
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47024357
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46769022
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.45398637
57CTCF_27219007_Chip-Seq_Bcells_Human1.45202138
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.44386454
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.43486690
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43273699
61ERA_21632823_ChIP-Seq_H3396_Human1.43014155
62CTCF_21964334_Chip-Seq_Bcells_Human1.42724849
63UTX_26944678_Chip-Seq_JUKART_Human1.41198548
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40738664
65MAF_26560356_Chip-Seq_TH1_Human1.39786953
66ZNF274_21170338_ChIP-Seq_K562_Hela1.39033695
67MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.37719266
68* P300_27268052_Chip-Seq_Bcells_Human1.37661241
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34837100
70TP53_22573176_ChIP-Seq_HFKS_Human1.34489248
71P68_20966046_ChIP-Seq_HELA_Human1.31760819
72RACK7_27058665_Chip-Seq_MCF-7_Human1.31690949
73VDR_22108803_ChIP-Seq_LS180_Human1.31667467
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30989847
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30668721
76LXR_22292898_ChIP-Seq_THP-1_Human1.30449573
77* MAF_26560356_Chip-Seq_TH2_Human1.30253334
78* GATA3_21878914_ChIP-Seq_MCF-7_Human1.28953561
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27538764
80STAT1_20625510_ChIP-Seq_HELA_Human1.26907678
81SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.26494383
82* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26017038
83CREB1_26743006_Chip-Seq_LNCaP_Human1.25587497
84FOXP1_21924763_ChIP-Seq_HESCs_Human1.24158555
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23939514
86RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23335385
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22570630
88RUNX_20019798_ChIP-Seq_JUKART_Human1.22415925
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21801700
90FOXM1_23109430_ChIP-Seq_U2OS_Human1.20130983
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.20033291
92SPI1_20517297_ChIP-Seq_HL60_Human1.19492969
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18764190
94GATA4_21415370_ChIP-Seq_HL-1_Mouse1.18300453
95CTCF_26484167_Chip-Seq_Bcells_Mouse1.18133680
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17216806
97* MYC_19829295_ChIP-Seq_ESCs_Human1.16994126
98NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.16975475
99* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15941446
100* RAC3_21632823_ChIP-Seq_H3396_Human1.15403291
101OCT4_19829295_ChIP-Seq_ESCs_Human1.15229900
102GATA1_19941827_ChIP-Seq_MEL_Mouse1.13998675
103* FOXH1_21741376_ChIP-Seq_ESCs_Human1.13521050
104* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.13004539
105PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12647738
106SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12178084
107TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11859221
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11797326
109SCL_19346495_ChIP-Seq_HPC-7_Human1.11411872
110KDM2B_26808549_Chip-Seq_DND41_Human1.11374284
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11363642
112* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11323895
113VDR_21846776_ChIP-Seq_THP-1_Human1.10873361
114NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10205722
115ELF1_20517297_ChIP-Seq_JURKAT_Human1.09693616
116ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09418919
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08341779
118CEBPB_22108803_ChIP-Seq_LS180_Human1.08253608
119EZH2_27294783_Chip-Seq_ESCs_Mouse1.08096523
120NANOG_21062744_ChIP-ChIP_HESCs_Human1.07453639
121CTCF_20526341_ChIP-Seq_ESCs_Human1.06779955
122HOXB7_26014856_ChIP-Seq_BT474_Human1.06403436
123HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05555317
124TDRD3_21172665_ChIP-Seq_MCF-7_Human1.05356191
125E2F1_20622854_ChIP-Seq_HELA_Human1.05282799
126MYC_22102868_ChIP-Seq_BL_Human1.04656310
127SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04616987
128EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04523970
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04236469
130ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03740125
131* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02773111
132* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02731051
133RARA_24833708_ChIP-Seq_LIVER_Mouse1.02527002
134PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02129952
135FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01740019
136GATA3_27048872_Chip-Seq_THYMUS_Human1.01465417
137YY1_21170310_ChIP-Seq_MESCs_Mouse1.01155968
138* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99060062
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.97910066
140KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97569460
141RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97386623
142POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97166485
143AR_21572438_ChIP-Seq_LNCaP_Human0.96998008
144NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96966350
145* NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96876122
146GATA3_21867929_ChIP-Seq_TH1_Mouse0.96696285
147P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95099509
148ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94671377
149TP63_22573176_ChIP-Seq_HFKS_Human0.94399074
150MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93422301
151FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.93276013
152CIITA_25753668_ChIP-Seq_RAJI_Human0.92785871
153NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92118354
154P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91532404
155OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91109038
156* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90793894
157CHD1_26751641_Chip-Seq_LNCaP_Human0.90528667
158TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90240688
159MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90184120
160SMC4_20622854_ChIP-Seq_HELA_Human0.90111919
161PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.89310062
162DCP1A_22483619_ChIP-Seq_HELA_Human0.89255666
163SA1_27219007_Chip-Seq_ERYTHROID_Human0.88432082
164TCF7_22412390_ChIP-Seq_EML_Mouse0.88249502
165ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87985430
166GABP_17652178_ChIP-ChIP_JURKAT_Human0.87971248
167KDM5A_27292631_Chip-Seq_BREAST_Human0.87731835
168ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87542411

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio7.91478367
2MP0003646_muscle_fatigue6.40081848
3MP0000749_muscle_degeneration6.23841716
4MP0000751_myopathy5.35153441
5MP0000747_muscle_weakness4.54020602
6MP0002106_abnormal_muscle_physiology4.19379596
7MP0002269_muscular_atrophy3.86710722
8MP0004036_abnormal_muscle_relaxation3.86433151
9MP0000759_abnormal_skeletal_muscle3.79547220
10MP0000750_abnormal_muscle_regeneration3.53591880
11MP0005369_muscle_phenotype3.47219841
12MP0004087_abnormal_muscle_fiber3.32761677
13MP0002837_dystrophic_cardiac_calcinosis3.11650144
14MP0004233_abnormal_muscle_weight2.99173681
15MP0005620_abnormal_muscle_contractility2.92856178
16MP0004130_abnormal_muscle_cell2.86778573
17MP0002332_abnormal_exercise_endurance2.36616865
18MP0000733_abnormal_muscle_development2.36207922
19MP0005645_abnormal_hypothalamus_physiol2.12778713
20MP0006036_abnormal_mitochondrial_physio2.10175091
21MP0005330_cardiomyopathy2.04515737
22MP0002108_abnormal_muscle_morphology1.91069764
23MP0002653_abnormal_ependyma_morphology1.76579971
24MP0004185_abnormal_adipocyte_glucose1.72600195
25MP0004084_abnormal_cardiac_muscle1.68308351
26MP0005167_abnormal_blood-brain_barrier1.67029205
27MP0003221_abnormal_cardiomyocyte_apopto1.49653300
28MP0003806_abnormal_nucleotide_metabolis1.43866259
29MP0005671_abnormal_response_to1.37363059
30MP0005266_abnormal_metabolism1.30860483
31MP0004215_abnormal_myocardial_fiber1.28617651
32MP0005666_abnormal_adipose_tissue1.26777563
33MP0003136_yellow_coat_color1.26555419
34MP0002971_abnormal_brown_adipose1.24953899
35MP0001986_abnormal_taste_sensitivity1.24147193
36MP0006035_abnormal_mitochondrial_morpho1.21798839
37MP0003763_abnormal_thymus_physiology1.20648436
38MP0010630_abnormal_cardiac_muscle1.16771332
39MP0004270_analgesia1.11948474
40MP0002972_abnormal_cardiac_muscle1.09387477
41MP0004484_altered_response_of1.06046267
42MP0003045_fibrosis1.05585783
43MP0004381_abnormal_hair_follicle0.98410070
44MP0003656_abnormal_erythrocyte_physiolo0.97067754
45MP0003137_abnormal_impulse_conducting0.95951271
46MP0005375_adipose_tissue_phenotype0.93883090
47MP0008872_abnormal_physiological_respon0.93741329
48MP0003705_abnormal_hypodermis_morpholog0.92982856
49MP0002102_abnormal_ear_morphology0.91829028
50MP0004043_abnormal_pH_regulation0.89720007
51MP0000013_abnormal_adipose_tissue0.89104293
52MP0004510_myositis0.88021686
53MP0000762_abnormal_tongue_morphology0.86045074
54MP0002876_abnormal_thyroid_physiology0.82132741
55MP0001873_stomach_inflammation0.79610167
56MP0005360_urolithiasis0.79289625
57MP0008789_abnormal_olfactory_epithelium0.79021259
58MP0001485_abnormal_pinna_reflex0.77230124
59MP0001544_abnormal_cardiovascular_syste0.77160044
60MP0005385_cardiovascular_system_phenoty0.77160044
61MP0008961_abnormal_basal_metabolism0.77057480
62MP0002127_abnormal_cardiovascular_syste0.75755920
63MP0002638_abnormal_pupillary_reflex0.74618534
64MP0009278_abnormal_bone_marrow0.72177860
65MP0000230_abnormal_systemic_arterial0.71535980
66MP0001529_abnormal_vocalization0.70960514
67MP0001984_abnormal_olfaction0.68650523
68MP0001968_abnormal_touch/_nociception0.68153881
69MP0005083_abnormal_biliary_tract0.67989292
70MP0005386_behavior/neurological_phenoty0.66370232
71MP0004924_abnormal_behavior0.66370232
72MP0004134_abnormal_chest_morphology0.66072932
73MP0002723_abnormal_immune_serum0.65241641
74MP0003950_abnormal_plasma_membrane0.65084263
75MP0002254_reproductive_system_inflammat0.64389470
76MP0001501_abnormal_sleep_pattern0.64023791
77MP0000685_abnormal_immune_system0.63913607
78MP0001800_abnormal_humoral_immune0.63457950
79MP0009250_abnormal_appendicular_skeleto0.62879547
80MP0002693_abnormal_pancreas_physiology0.62515640
81MP0005451_abnormal_body_composition0.61426899
82MP0002234_abnormal_pharynx_morphology0.61392201
83MP0009672_abnormal_birth_weight0.60422239
84MP0010329_abnormal_lipoprotein_level0.59433996
85MP0003693_abnormal_embryo_hatching0.59392791
86MP0002078_abnormal_glucose_homeostasis0.58142470
87MP0000266_abnormal_heart_morphology0.57955278
88MP0001661_extended_life_span0.57760876
89MP0005000_abnormal_immune_tolerance0.55670154
90MP0001765_abnormal_ion_homeostasis0.55618728
91MP0005551_abnormal_eye_electrophysiolog0.53754123
92MP0000003_abnormal_adipose_tissue0.53471496
93MP0000372_irregular_coat_pigmentation0.53295148
94MP0001835_abnormal_antigen_presentation0.53237589
95MP0000579_abnormal_nail_morphology0.51748412
96MP0001790_abnormal_immune_system0.50920774
97MP0005387_immune_system_phenotype0.50920774
98MP0004133_heterotaxia0.50119189
99MP0001819_abnormal_immune_cell0.49864342
100MP0001299_abnormal_eye_distance/0.49839572
101MP0003011_delayed_dark_adaptation0.49755891
102MP0002114_abnormal_axial_skeleton0.49588421
103MP0002420_abnormal_adaptive_immunity0.49340967
104MP0005452_abnormal_adipose_tissue0.49206621
105MP0001849_ear_inflammation0.49036420
106MP0001664_abnormal_digestion0.47903682
107MP0005332_abnormal_amino_acid0.47314107
108MP0000689_abnormal_spleen_morphology0.47279993
109MP0003567_abnormal_fetal_cardiomyocyte0.47205491
110MP0004957_abnormal_blastocyst_morpholog0.45906020
111MP0006138_congestive_heart_failure0.45899932
112MP0008775_abnormal_heart_ventricle0.45649732
113MP0004147_increased_porphyrin_level0.45593511
114MP0005334_abnormal_fat_pad0.44257125
115MP0001730_embryonic_growth_arrest0.43174152
116MP0002796_impaired_skin_barrier0.42703103
117MP0005670_abnormal_white_adipose0.42150618
118MP0005319_abnormal_enzyme/_coenzyme0.41393245
119MP0004197_abnormal_fetal_growth/weight/0.40750152
120MP0003828_pulmonary_edema0.37279837
121MP0003755_abnormal_palate_morphology0.34680071
122MP0008770_decreased_survivor_rate0.34444279
123MP0000383_abnormal_hair_follicle0.33855219
124MP0004142_abnormal_muscle_tone0.32931777
125MP0010030_abnormal_orbit_morphology0.32428587
126MP0008057_abnormal_DNA_replication0.31889870
127MP0003111_abnormal_nucleus_morphology0.30779530
128MP0000358_abnormal_cell_content/0.30364497
129MP0005076_abnormal_cell_differentiation0.29268429
130MP0000678_abnormal_parathyroid_gland0.29108950
131MP0003984_embryonic_growth_retardation0.28666524
132MP0003941_abnormal_skin_development0.28345120
133MP0002089_abnormal_postnatal_growth/wei0.28054148
134MP0002088_abnormal_embryonic_growth/wei0.28021625
135MP0001672_abnormal_embryogenesis/_devel0.27950645
136MP0005380_embryogenesis_phenotype0.27950645
137MP0005376_homeostasis/metabolism_phenot0.27320025
138MP0003959_abnormal_lean_body0.26849046
139MP0010094_abnormal_chromosome_stability0.26694838
140MP0003123_paternal_imprinting0.26509032
141MP0005584_abnormal_enzyme/coenzyme_acti0.26478526
142MP0009703_decreased_birth_body0.26013247
143MP0000343_altered_response_to0.25975313
144MP0002877_abnormal_melanocyte_morpholog0.24264183
145MP0002970_abnormal_white_adipose0.23962207
146MP0004085_abnormal_heartbeat0.23528341

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.52980874
2Nemaline bodies (HP:0003798)9.03967132
3Exercise-induced myalgia (HP:0003738)8.47609354
4Exercise-induced muscle cramps (HP:0003710)7.77959535
5Type 1 muscle fiber predominance (HP:0003803)7.12806545
6Distal arthrogryposis (HP:0005684)7.10396806
7Myopathic facies (HP:0002058)6.94402425
8Muscle hypertrophy of the lower extremities (HP:0008968)6.78319230
9Ulnar deviation of the wrist (HP:0003049)6.21832410
10Calf muscle hypertrophy (HP:0008981)5.97546045
11Round ear (HP:0100830)5.92237612
12Calcaneovalgus deformity (HP:0001848)5.47466814
13Difficulty running (HP:0009046)5.38273096
14Muscle fiber splitting (HP:0003555)5.10444869
15Deformed tarsal bones (HP:0008119)5.00701259
16Myoglobinuria (HP:0002913)4.95324433
17Absent phalangeal crease (HP:0006109)4.82789692
18Muscle stiffness (HP:0003552)4.67721153
19Hyporeflexia of lower limbs (HP:0002600)4.54330479
20EMG: myopathic abnormalities (HP:0003458)4.44087478
21Increased connective tissue (HP:0009025)4.29911377
22Rhabdomyolysis (HP:0003201)4.22133635
23Myotonia (HP:0002486)4.10130557
24Abnormal finger flexion creases (HP:0006143)4.00873801
25Abnormality of the calf musculature (HP:0001430)3.91943099
26Difficulty climbing stairs (HP:0003551)3.68944223
27Abnormality of skeletal muscle fiber size (HP:0012084)3.64061399
28Pelvic girdle muscle weakness (HP:0003749)3.59243237
29Shoulder girdle muscle weakness (HP:0003547)3.58312450
30Areflexia of lower limbs (HP:0002522)3.55028762
31Neck muscle weakness (HP:0000467)3.53799657
32Malignant hyperthermia (HP:0002047)3.53603860
33Rimmed vacuoles (HP:0003805)3.49407741
34Subaortic stenosis (HP:0001682)3.49306951
35Abnormality of the left ventricular outflow tract (HP:0011103)3.49306951
36Abnormality of the hip-girdle musculature (HP:0001445)3.47234516
37Abnormality of the musculature of the pelvis (HP:0001469)3.47234516
38Type II lissencephaly (HP:0007260)3.38935311
39Abnormality of the calcaneus (HP:0008364)3.34348584
40Increased variability in muscle fiber diameter (HP:0003557)3.20823408
41Progressive muscle weakness (HP:0003323)3.08699215
42Frequent falls (HP:0002359)2.95946371
43Cerebellar dysplasia (HP:0007033)2.94816096
44Heart block (HP:0012722)2.80616195
45Hyperkalemia (HP:0002153)2.75631133
46Anterior segment dysgenesis (HP:0007700)2.67072718
47EMG: neuropathic changes (HP:0003445)2.66590654
48Asymmetric septal hypertrophy (HP:0001670)2.64435359
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62164218
50Dicarboxylic aciduria (HP:0003215)2.62164218
51Fatigable weakness (HP:0003473)2.58979932
52Abnormality of the neuromuscular junction (HP:0003398)2.58979932
53Distal lower limb muscle weakness (HP:0009053)2.55307421
54Paralysis (HP:0003470)2.52594143
55Abnormal atrioventricular conduction (HP:0005150)2.51020750
56Sudden death (HP:0001699)2.37407622
57Proximal amyotrophy (HP:0007126)2.32535158
58Mildly elevated creatine phosphokinase (HP:0008180)2.31567510
59Slender build (HP:0001533)2.29091523
60Stridor (HP:0010307)2.27974531
61Limb-girdle muscle weakness (HP:0003325)2.27845036
62Muscular dystrophy (HP:0003560)2.25421528
63Increased muscle lipid content (HP:0009058)2.23580662
64Abnormality of the shoulder girdle musculature (HP:0001435)2.18209455
65Hypoplastic ischia (HP:0003175)2.15325699
66Left ventricular hypertrophy (HP:0001712)2.15038264
67Hepatic necrosis (HP:0002605)2.13159219
68Increased intramyocellular lipid droplets (HP:0012240)2.11815106
69Generalized muscle weakness (HP:0003324)2.09973177
70Fetal akinesia sequence (HP:0001989)2.08451269
71Bulbar palsy (HP:0001283)2.08161709
72Severe muscular hypotonia (HP:0006829)2.08013237
73Achilles tendon contracture (HP:0001771)2.07371569
74Abnormality of alanine metabolism (HP:0010916)2.04915609
75Hyperalaninemia (HP:0003348)2.04915609
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04915609
77Metatarsus adductus (HP:0001840)2.04081192
78Gout (HP:0001997)2.02689633
79Gowers sign (HP:0003391)2.00436422
80Ulnar deviation of finger (HP:0009465)2.00115054
81Muscle fiber inclusion bodies (HP:0100299)10.0037997
82Facial diplegia (HP:0001349)1.97026406
83Limb-girdle muscle atrophy (HP:0003797)1.95725167
84Centrally nucleated skeletal muscle fibers (HP:0003687)1.94580720
85Hepatocellular necrosis (HP:0001404)1.92915736
86Congenital stationary night blindness (HP:0007642)1.92636374
87Spinal rigidity (HP:0003306)1.91265277
88Weak cry (HP:0001612)1.91145083
89Lissencephaly (HP:0001339)1.90966792
90Scapular winging (HP:0003691)1.87394589
91Dilated cardiomyopathy (HP:0001644)1.86422078
92Abnormality of the ischium (HP:0003174)1.85907513
93Abnormality of the Achilles tendon (HP:0005109)1.85319612
94Nonprogressive disorder (HP:0003680)1.85002110
95Short palpebral fissure (HP:0012745)1.84802946
96Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83016086
97Methylmalonic aciduria (HP:0012120)1.81947682
98Distal lower limb amyotrophy (HP:0008944)1.77829133
99Increased purine levels (HP:0004368)1.77791213
100Hyperuricemia (HP:0002149)1.77791213
101Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77751080
102Cerebral palsy (HP:0100021)1.77681411
103Hyperglycinuria (HP:0003108)1.74846604
104Renal cortical cysts (HP:0000803)1.73833422
105Ketosis (HP:0001946)1.72646522
106Hip contracture (HP:0003273)1.70844756
107Waddling gait (HP:0002515)1.70825446
108Large for gestational age (HP:0001520)1.68432796
109Ragged-red muscle fibers (HP:0003200)1.67728189
110Genetic anticipation (HP:0003743)1.65056611
111Elevated erythrocyte sedimentation rate (HP:0003565)1.64344171
112Congenital hip dislocation (HP:0001374)1.63516403
113Testicular atrophy (HP:0000029)1.62957587
114Ventricular tachycardia (HP:0004756)1.62616743
115Easy fatigability (HP:0003388)1.59714431
116Mitochondrial inheritance (HP:0001427)1.59388966
117Aplasia/Hypoplasia of the spleen (HP:0010451)1.59298055
118Bundle branch block (HP:0011710)1.56506057
119Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.53699101
120Respiratory insufficiency due to muscle weakness (HP:0002747)1.52802281
121Type 2 muscle fiber atrophy (HP:0003554)1.51274432
122Ketoacidosis (HP:0001993)1.50662996
123Adducted thumb (HP:0001181)1.50456830
124Abnormal mitochondria in muscle tissue (HP:0008316)1.49380021
125Abnormality of lateral ventricle (HP:0030047)1.48893140
126Tarsal synostosis (HP:0008368)1.48728430
127Decreased circulating renin level (HP:0003351)1.48726199
128Methylmalonic acidemia (HP:0002912)1.48506243
129Lipoatrophy (HP:0100578)1.48397202
130Exercise intolerance (HP:0003546)1.47986136
131Cholelithiasis (HP:0001081)1.40623869
132Increased density of long bones (HP:0006392)1.40608654
133Oligomenorrhea (HP:0000876)1.39612081
134Muscle fiber atrophy (HP:0100295)1.39027453
135Abnormality of potassium homeostasis (HP:0011042)1.36660297
136Synostosis involving bones of the lower limbs (HP:0009138)1.32470813
137Synostosis involving bones of the feet (HP:0009140)1.32470813
138Webbed neck (HP:0000465)1.29538978
139Long clavicles (HP:0000890)1.28235094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN8.52096992
2TTN5.83928485
3PHKG15.22210945
4PHKG25.22210945
5NME14.52155741
6PIK3CG3.41204662
7NEK13.07228417
8TAOK32.93623607
9MAP2K32.64498905
10PINK12.41907553
11EPHA32.41345165
12PDK42.18660862
13PDK32.18660862
14BCKDK2.00239325
15MAP4K11.99651170
16TXK1.92893883
17MAP3K71.83912461
18SIK21.71981279
19MAP2K41.63956001
20MAPK121.57208819
21FRK1.55927132
22PDK21.55550219
23GRK61.53509408
24ADRBK21.52497342
25DAPK21.51866466
26TRIB31.48019606
27DMPK1.45307053
28TLK11.44643106
29WNK41.42419301
30TESK21.35543335
31MAP2K61.34890230
32TNK21.29054249
33MUSK1.23090938
34TBK11.22097799
35DYRK1B1.18365995
36PIK3CA1.09265248
37MAP3K31.07985385
38MAPKAPK31.05499475
39RIPK11.02256860
40KDR1.00122460
41KIT0.99335738
42CAMK40.97287449
43MAP4K20.94608993
44STK240.93184284
45MAP2K20.92215352
46PRKAA10.92178064
47IKBKE0.91340661
48MAPK130.89323844
49MAP3K130.88787224
50GRK10.86381713
51MARK10.81249192
52RPS6KA60.81197155
53TAOK10.80420867
54TAOK20.80017279
55MAP3K60.78281940
56SYK0.75062547
57AKT20.74458380
58MAPK110.73545501
59IKBKB0.73004482
60PRKAA20.71427228
61LATS20.70770174
62MAP3K110.69489082
63MAP3K140.69105759
64IRAK40.68100833
65PRKCQ0.67306348
66ITK0.67096084
67ZAK0.64026019
68SIK10.63405421
69RPS6KA50.63365430
70PNCK0.63244337
71WEE10.61333497
72RPS6KC10.61085334
73RPS6KL10.61085334
74MAP3K100.61022181
75EPHA20.58149239
76TTK0.57707146
77CCNB10.57242035
78CDC42BPA0.57230455
79EPHB10.53151737
80MAP2K10.52383075
81PRKCH0.52077121
82INSRR0.51889549
83TRPM70.51430977
84STK110.51076123
85CAMK10.50357479
86CHUK0.50167398
87DYRK30.49926105
88ZAP700.48434876
89PKN20.48366401
90BTK0.46892198
91NME20.46879324
92MARK30.46610383
93CAMK2G0.45507152
94PRKD30.45296346
95PKN10.44748060
96AKT30.44600028
97STK38L0.44190795
98LCK0.43972275
99BMPR1B0.43914877
100NEK90.43074893
101ADRBK10.42974662
102MAPK150.41129085
103ICK0.40498823
104EEF2K0.38530154
105OXSR10.36858010
106CAMK2A0.36819144
107PRKD20.36433634
108PTK2B0.36339898
109TIE10.35865879
110MARK20.35723222
111RPS6KA20.34359965
112TNIK0.33200960
113LATS10.32854819
114MAP3K50.32237016
115CAMKK10.31840539
116RPS6KB20.30871395
117HCK0.30335660
118PRKACB0.30295366
119CAMK2D0.30197402
120ERBB30.29070409
121CAMKK20.28545118
122GRK70.27336281
123TYK20.27031625
124MAPK30.26831179
125RPS6KA30.25428263
126STK30.25261479
127MAPK70.24474152
128BUB10.24450959
129NEK20.24214393
130ALK0.22914972
131MTOR0.20451766
132ILK0.20439759
133PLK10.19430548
134DDR20.19209026
135SGK10.18056196
136STK380.17505520
137MAPK100.16124241
138CDK40.15711040
139ERN10.14817719
140PRKACA0.14708690
141MAPK40.14590520
142BRSK20.14350649
143GSK3A0.13545552
144CDK80.13211269
145EIF2AK10.12772776
146AURKA0.12616785
147BMX0.12219389
148CDK120.12166624
149RPS6KA10.11913472
150MOS0.11905351
151GRK50.11672909
152LIMK10.11600447
153TYRO30.11262960
154PAK60.09902286
155CSNK1E0.09296370
156PRKG10.09294101
157MAP3K80.08679155
158PRKDC0.08141240
159KSR20.07203125
160CDK20.06533956
161PTK60.06328752
162RPS6KB10.06159775
163FLT30.05556412
164CHEK10.04299127
165CDK70.04287070
166TSSK60.03489870
167CHEK20.02877687

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.25956881
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.75819719
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.65536614
4Cardiac muscle contraction_Homo sapiens_hsa042603.31414629
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.12238580
6Vitamin B6 metabolism_Homo sapiens_hsa007503.06763457
7Primary immunodeficiency_Homo sapiens_hsa053402.99935261
8Circadian rhythm_Homo sapiens_hsa047102.93102002
9Dilated cardiomyopathy_Homo sapiens_hsa054142.78823315
10Starch and sucrose metabolism_Homo sapiens_hsa005002.69495326
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.57303807
12Carbon metabolism_Homo sapiens_hsa012002.38609860
13Fructose and mannose metabolism_Homo sapiens_hsa000512.23882258
14Galactose metabolism_Homo sapiens_hsa000522.20933197
15Biosynthesis of amino acids_Homo sapiens_hsa012302.18796906
16Glucagon signaling pathway_Homo sapiens_hsa049222.18103415
17Insulin signaling pathway_Homo sapiens_hsa049102.10313664
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.05000849
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04579947
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.00065764
21Propanoate metabolism_Homo sapiens_hsa006401.98259440
22Nitrogen metabolism_Homo sapiens_hsa009101.95826733
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.95797115
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85278408
25Oxytocin signaling pathway_Homo sapiens_hsa049211.78549008
26Insulin resistance_Homo sapiens_hsa049311.75828476
27AMPK signaling pathway_Homo sapiens_hsa041521.71373603
28Phototransduction_Homo sapiens_hsa047441.67384874
29Arginine and proline metabolism_Homo sapiens_hsa003301.66170255
30Parkinsons disease_Homo sapiens_hsa050121.65941361
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57510025
32Pentose phosphate pathway_Homo sapiens_hsa000301.52221459
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.43852810
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43386962
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42548857
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38776672
37Ether lipid metabolism_Homo sapiens_hsa005651.38281364
38Oxidative phosphorylation_Homo sapiens_hsa001901.35915434
39Calcium signaling pathway_Homo sapiens_hsa040201.35401545
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.33896099
41Tight junction_Homo sapiens_hsa045301.33701008
42Fanconi anemia pathway_Homo sapiens_hsa034601.27571059
43Alzheimers disease_Homo sapiens_hsa050101.27499240
44Peroxisome_Homo sapiens_hsa041461.27381445
45Fatty acid biosynthesis_Homo sapiens_hsa000611.27284987
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25748102
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22948273
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22924453
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21999458
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21389128
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20354378
52ABC transporters_Homo sapiens_hsa020101.18243901
53mTOR signaling pathway_Homo sapiens_hsa041501.14777775
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09887569
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09069985
56Pyruvate metabolism_Homo sapiens_hsa006201.06128988
57Longevity regulating pathway - mammal_Homo sapiens_hsa042111.05149534
58Viral myocarditis_Homo sapiens_hsa054161.03440756
59RNA transport_Homo sapiens_hsa030131.02830870
60Ovarian steroidogenesis_Homo sapiens_hsa049131.01478925
61Tryptophan metabolism_Homo sapiens_hsa003801.00492933
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98045597
63Antigen processing and presentation_Homo sapiens_hsa046120.93265453
64Graft-versus-host disease_Homo sapiens_hsa053320.92603192
65Sulfur relay system_Homo sapiens_hsa041220.91028758
66Huntingtons disease_Homo sapiens_hsa050160.88928122
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88456327
68Salivary secretion_Homo sapiens_hsa049700.87948907
69RNA polymerase_Homo sapiens_hsa030200.87891041
70FoxO signaling pathway_Homo sapiens_hsa040680.86113185
71Fatty acid degradation_Homo sapiens_hsa000710.85094874
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84209562
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.83069410
74Proteasome_Homo sapiens_hsa030500.82202029
75Fatty acid metabolism_Homo sapiens_hsa012120.81798619
76Olfactory transduction_Homo sapiens_hsa047400.81444724
77Arginine biosynthesis_Homo sapiens_hsa002200.77331466
78Regulation of autophagy_Homo sapiens_hsa041400.77129858
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75900919
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74335609
81T cell receptor signaling pathway_Homo sapiens_hsa046600.73331996
82Purine metabolism_Homo sapiens_hsa002300.71238210
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.70684863
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.69457702
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.69274903
86GnRH signaling pathway_Homo sapiens_hsa049120.69177068
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68056305
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.64856734
89HIF-1 signaling pathway_Homo sapiens_hsa040660.64740797
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63234953
91Allograft rejection_Homo sapiens_hsa053300.58665974
92RNA degradation_Homo sapiens_hsa030180.56930280
93Type I diabetes mellitus_Homo sapiens_hsa049400.56273769
94Fat digestion and absorption_Homo sapiens_hsa049750.56201925
95Folate biosynthesis_Homo sapiens_hsa007900.55084235
96Pancreatic secretion_Homo sapiens_hsa049720.52866291
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.52208822
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.51109903
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51012918
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.50752622
101beta-Alanine metabolism_Homo sapiens_hsa004100.50019356
102Oocyte meiosis_Homo sapiens_hsa041140.49471938
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49182886
104MAPK signaling pathway_Homo sapiens_hsa040100.48853859
105Focal adhesion_Homo sapiens_hsa045100.48833391
106Lysine degradation_Homo sapiens_hsa003100.47777879
107Ribosome_Homo sapiens_hsa030100.46916936
108Autoimmune thyroid disease_Homo sapiens_hsa053200.46263934
109Circadian entrainment_Homo sapiens_hsa047130.44843378
110VEGF signaling pathway_Homo sapiens_hsa043700.44405105
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43684278
112Taste transduction_Homo sapiens_hsa047420.42964327
113Gastric acid secretion_Homo sapiens_hsa049710.42764419
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42225669
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40480699
116B cell receptor signaling pathway_Homo sapiens_hsa046620.38108475
117Metabolic pathways_Homo sapiens_hsa011000.37330148
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35895078
119Hematopoietic cell lineage_Homo sapiens_hsa046400.35426434
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34374792
121Linoleic acid metabolism_Homo sapiens_hsa005910.33862722
122Arachidonic acid metabolism_Homo sapiens_hsa005900.32861183
123Base excision repair_Homo sapiens_hsa034100.32443755
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32049791
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31423757
126Platelet activation_Homo sapiens_hsa046110.31185661
127Morphine addiction_Homo sapiens_hsa050320.31013052
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27158230
129Glycerolipid metabolism_Homo sapiens_hsa005610.27146115
130Notch signaling pathway_Homo sapiens_hsa043300.26823438
131Insulin secretion_Homo sapiens_hsa049110.26267361
132mRNA surveillance pathway_Homo sapiens_hsa030150.23268273
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21330632
134Mismatch repair_Homo sapiens_hsa034300.19638261
135Adherens junction_Homo sapiens_hsa045200.19239179
136Hippo signaling pathway_Homo sapiens_hsa043900.15526395
137Cell cycle_Homo sapiens_hsa041100.14353358
138Renal cell carcinoma_Homo sapiens_hsa052110.12374101
139Thyroid cancer_Homo sapiens_hsa052160.10957701
140p53 signaling pathway_Homo sapiens_hsa041150.10868012
141Pyrimidine metabolism_Homo sapiens_hsa002400.10268130
142Protein digestion and absorption_Homo sapiens_hsa049740.10208709
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09018537
144Butanoate metabolism_Homo sapiens_hsa006500.07868525
145Proteoglycans in cancer_Homo sapiens_hsa052050.06594454
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.06194271
147Basal cell carcinoma_Homo sapiens_hsa052170.03908284

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »