ASB17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome assembly (GO:0001675)9.88679662
2multicellular organism reproduction (GO:0032504)9.72475855
3binding of sperm to zona pellucida (GO:0007339)9.40695371
4cell-cell recognition (GO:0009988)9.18874224
5plasma membrane fusion (GO:0045026)9.04157497
6reproduction (GO:0000003)8.40843128
7epithelial cilium movement (GO:0003351)8.35650256
8cilium or flagellum-dependent cell motility (GO:0001539)8.29053061
9motile cilium assembly (GO:0044458)8.20469048
10axonemal dynein complex assembly (GO:0070286)8.19578265
11spermatid development (GO:0007286)8.05318710
12regulation of cilium movement (GO:0003352)6.77377833
13cilium movement (GO:0003341)6.66845910
14single fertilization (GO:0007338)6.44619642
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.15922238
16sperm capacitation (GO:0048240)6.07986140
17microtubule depolymerization (GO:0007019)5.89395925
18synaptonemal complex assembly (GO:0007130)5.82924398
19synaptonemal complex organization (GO:0070193)5.81959943
20male meiosis (GO:0007140)5.78020567
21piRNA metabolic process (GO:0034587)5.56325519
22spermatid nucleus differentiation (GO:0007289)5.46795069
23spermatogenesis (GO:0007283)5.30106075
24male gamete generation (GO:0048232)5.28960481
25fertilization (GO:0009566)5.28762632
26organic cation transport (GO:0015695)5.14301106
27single strand break repair (GO:0000012)5.06866173
28negative regulation of inclusion body assembly (GO:0090084)4.93882942
29gamete generation (GO:0007276)4.85770452
30glycerol ether metabolic process (GO:0006662)4.52594457
31calcium ion-dependent exocytosis (GO:0017156)4.48542855
32regulation of inclusion body assembly (GO:0090083)4.42049327
33cellular process involved in reproduction in multicellular organism (GO:0022412)4.39264404
34chromosome condensation (GO:0030261)4.38442970
35chromosome organization involved in meiosis (GO:0070192)4.34971480
36germ cell development (GO:0007281)4.33457441
37protoporphyrinogen IX biosynthetic process (GO:0006782)4.30395146
38DNA packaging (GO:0006323)4.22542299
39protoporphyrinogen IX metabolic process (GO:0046501)4.21953339
40ether metabolic process (GO:0018904)4.17307918
41cell recognition (GO:0008037)4.14290119
42male meiosis I (GO:0007141)4.12674543
43microtubule severing (GO:0051013)4.09544950
44monoubiquitinated protein deubiquitination (GO:0035520)4.07327286
45ventricular system development (GO:0021591)4.06608132
46meiotic nuclear division (GO:0007126)3.94364665
47chaperone-mediated protein complex assembly (GO:0051131)3.88651224
48heme biosynthetic process (GO:0006783)3.81917550
49multicellular organismal reproductive process (GO:0048609)3.81740074
50sexual reproduction (GO:0019953)3.80128583
51DNA deamination (GO:0045006)3.76709019
52regulation of microtubule-based movement (GO:0060632)3.76662643
53DNA methylation involved in gamete generation (GO:0043046)3.66531952
54histone exchange (GO:0043486)3.64204738
55meiosis I (GO:0007127)3.60457170
56porphyrin-containing compound biosynthetic process (GO:0006779)3.49207505
57protein K11-linked deubiquitination (GO:0035871)3.41619688
58regulation of spindle checkpoint (GO:0090231)3.30834204
59GTP biosynthetic process (GO:0006183)3.29348536
60seminiferous tubule development (GO:0072520)3.28621723
61heme metabolic process (GO:0042168)3.26035878
62microtubule polymerization or depolymerization (GO:0031109)3.24345159
63meiotic cell cycle (GO:0051321)3.22022435
64centriole assembly (GO:0098534)3.20376955
65polyamine biosynthetic process (GO:0006596)3.17635787
66UTP biosynthetic process (GO:0006228)3.12080851
67protein localization to chromosome, centromeric region (GO:0071459)3.07137615
68tetrapyrrole biosynthetic process (GO:0033014)3.06907068
69multicellular organismal development (GO:0007275)3.00952078
70DNA replication-dependent nucleosome assembly (GO:0006335)3.00317380
71DNA replication-dependent nucleosome organization (GO:0034723)3.00317380
72protein polyglutamylation (GO:0018095)2.98640431
73nucleoside diphosphate phosphorylation (GO:0006165)2.98538528
74nucleus organization (GO:0006997)2.97231164
75protein refolding (GO:0042026)2.92087855
76UTP metabolic process (GO:0046051)2.90029536
77porphyrin-containing compound metabolic process (GO:0006778)2.89948712
78pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.86175144
79meiotic cell cycle process (GO:1903046)2.85705418
80nuclear pore complex assembly (GO:0051292)2.83049196
81left/right pattern formation (GO:0060972)2.80712354
82synapsis (GO:0007129)2.78640246
83cellular response to arsenic-containing substance (GO:0071243)2.78156281
84centriole replication (GO:0007099)2.73690528
85one-carbon compound transport (GO:0019755)2.73577318
86pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.72223322
87mitotic sister chromatid cohesion (GO:0007064)2.71847967
88genitalia morphogenesis (GO:0035112)2.66313156
89guanosine-containing compound biosynthetic process (GO:1901070)2.63579932
90regulation of response to osmotic stress (GO:0047484)2.58849855
91regulation of centriole replication (GO:0046599)2.57528617
92nuclear pore organization (GO:0006999)2.56782144
93positive regulation of macrophage activation (GO:0043032)2.55619141
94chromatin remodeling at centromere (GO:0031055)2.53730981
95cell wall macromolecule catabolic process (GO:0016998)12.6082849
96cell wall macromolecule metabolic process (GO:0044036)12.6082849
97fusion of sperm to egg plasma membrane (GO:0007342)12.0151751
98sperm motility (GO:0030317)11.2770579
99sperm-egg recognition (GO:0035036)10.2768811
100acrosome reaction (GO:0007340)10.0057187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.32521960
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.90146674
3E2F7_22180533_ChIP-Seq_HELA_Human3.59072815
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.78999563
5* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.51184099
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43014751
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.18427227
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17208739
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12781471
10FLI1_27457419_Chip-Seq_LIVER_Mouse1.99196123
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.89579478
12PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81221232
13E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78811773
14GATA1_26923725_Chip-Seq_HPCs_Mouse1.76601211
15KAP1_22055183_ChIP-Seq_ESCs_Mouse1.72673642
16* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.71413919
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71093831
18MYC_18555785_ChIP-Seq_MESCs_Mouse1.65340804
19GATA3_21867929_ChIP-Seq_CD8_Mouse1.65256441
20FOXM1_23109430_ChIP-Seq_U2OS_Human1.65177598
21RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.62059323
22MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58200787
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.56634431
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56249461
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52899382
26ZNF274_21170338_ChIP-Seq_K562_Hela1.47764463
27SOX2_22085726_ChIP-Seq_NPCs_Mouse1.46985992
28VDR_22108803_ChIP-Seq_LS180_Human1.44321307
29EZH2_22144423_ChIP-Seq_EOC_Human1.40527703
30* STAT1_17558387_ChIP-Seq_HELA_Human1.36960024
31FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36267702
32EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33707338
33SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31999339
34WDR5_24793694_ChIP-Seq_LNCAP_Human1.30855430
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29669879
36KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29593400
37YY1_22570637_ChIP-Seq_MALME-3M_Human1.27493182
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26698626
39FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25851456
40GATA3_21867929_ChIP-Seq_TH1_Mouse1.24299571
41P53_21459846_ChIP-Seq_SAOS-2_Human1.22356900
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21398758
43TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.21280645
44TAL1_26923725_Chip-Seq_HPCs_Mouse1.20177401
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.19005827
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.18849948
47GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.15473577
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14794591
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14078872
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13452020
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.12973370
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.11770152
53SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06758299
54AR_21909140_ChIP-Seq_LNCAP_Human1.05549327
55ERG_20517297_ChIP-Seq_VCAP_Human1.04428688
56LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04397030
57SPI1_26923725_Chip-Seq_HPCs_Mouse1.03584890
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01629162
59CBP_20019798_ChIP-Seq_JUKART_Human1.01450870
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01450870
61CTCF_26484167_Chip-Seq_Bcells_Mouse1.00653433
62EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00589594
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00130415
64KDM2B_26808549_Chip-Seq_REH_Human0.99795992
65VDR_23849224_ChIP-Seq_CD4+_Human0.99761103
66ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99671787
67RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99570275
68SCL_19346495_ChIP-Seq_HPC-7_Human0.98978582
69RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98508899
70MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97861231
71RARA_24833708_ChIP-Seq_LIVER_Mouse0.97233950
72TET1_21451524_ChIP-Seq_MESCs_Mouse0.96755465
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96737828
74CRX_20693478_ChIP-Seq_RETINA_Mouse0.96585391
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96319665
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96017855
77GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95888043
78YY1_21170310_ChIP-Seq_MESCs_Mouse0.95662612
79CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95196244
80* ELF1_20517297_ChIP-Seq_JURKAT_Human0.94413649
81KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.94170927
82SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94145250
83CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93751039
84LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.92839654
85PHF8_20622854_ChIP-Seq_HELA_Human0.91285693
86NANOG_20526341_ChIP-Seq_ESCs_Human0.90996779
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90766227
88GABP_19822575_ChIP-Seq_HepG2_Human0.90115482
89OCT4_18555785_Chip-Seq_ESCs_Mouse0.89507063
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89152686
91RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88736925
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88623063
93ESET_19884257_ChIP-Seq_ESCs_Mouse0.87156254
94CBX2_27304074_Chip-Seq_ESCs_Mouse0.86168203
95* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.85759405
96RUNX1_26923725_Chip-Seq_HPCs_Mouse0.84373823
97* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84306228
98SRF_21415370_ChIP-Seq_HL-1_Mouse0.83458484
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83272382
100FLI1_21867929_ChIP-Seq_CD8_Mouse0.83206933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.29118770
2MP0001929_abnormal_gametogenesis4.93005778
3MP0004147_increased_porphyrin_level4.10172357
4MP0003656_abnormal_erythrocyte_physiolo3.97509872
5MP0008877_abnormal_DNA_methylation3.58969563
6MP0002210_abnormal_sex_determination3.22237342
7MP0002161_abnormal_fertility/fecundity2.96672363
8MP0001145_abnormal_male_reproductive2.77185020
9MP0006054_spinal_hemorrhage2.57127568
10MP0008058_abnormal_DNA_repair2.51685168
11MP0000653_abnormal_sex_gland2.44740793
12MP0010094_abnormal_chromosome_stability2.41048735
13MP0003111_abnormal_nucleus_morphology2.12881097
14MP0005410_abnormal_fertilization13.6284093
15MP0005670_abnormal_white_adipose1.92991207
16MP0008057_abnormal_DNA_replication1.83089111
17MP0005397_hematopoietic_system_phenotyp1.81041004
18MP0001545_abnormal_hematopoietic_system1.81041004
19MP0003693_abnormal_embryo_hatching1.78590013
20MP0002653_abnormal_ependyma_morphology1.74287464
21MP0002160_abnormal_reproductive_system1.67568564
22MP0004957_abnormal_blastocyst_morpholog1.64940884
23MP0003646_muscle_fatigue1.57085332
24MP0006036_abnormal_mitochondrial_physio1.56898249
25MP0005636_abnormal_mineral_homeostasis1.54646194
26MP0003077_abnormal_cell_cycle1.49943361
27MP0003806_abnormal_nucleotide_metabolis1.44923044
28MP0002132_abnormal_respiratory_system1.33497429
29MP0002102_abnormal_ear_morphology1.32573036
30MP0004233_abnormal_muscle_weight1.13375381
31MP0001764_abnormal_homeostasis1.06317255
32MP0008007_abnormal_cellular_replicative1.02689075
33MP0006035_abnormal_mitochondrial_morpho0.95894233
34MP0005389_reproductive_system_phenotype0.95786944
35MP0000358_abnormal_cell_content/0.94993055
36MP0001765_abnormal_ion_homeostasis0.88783441
37MP0002396_abnormal_hematopoietic_system0.88654326
38MP0000490_abnormal_crypts_of0.88554515
39MP0002282_abnormal_trachea_morphology0.88341393
40MP0004215_abnormal_myocardial_fiber0.84012889
41MP0003786_premature_aging0.83770598
42MP0003186_abnormal_redox_activity0.82967128
43MP0000313_abnormal_cell_death0.81985435
44MP0001730_embryonic_growth_arrest0.77948653
45MP0005647_abnormal_sex_gland0.76813220
46MP0008932_abnormal_embryonic_tissue0.75878340
47MP0009046_muscle_twitch0.68079739
48MP0010307_abnormal_tumor_latency0.64893744
49MP0004043_abnormal_pH_regulation0.63515588
50MP0000350_abnormal_cell_proliferation0.59493949
51MP0001293_anophthalmia0.58791160
52MP0002269_muscular_atrophy0.56003943
53MP0002080_prenatal_lethality0.54366389
54MP0001984_abnormal_olfaction0.53653809
55MP0003699_abnormal_female_reproductive0.52413903
56MP0004808_abnormal_hematopoietic_stem0.51203749
57MP0002398_abnormal_bone_marrow0.50504125
58MP0001529_abnormal_vocalization0.50118247
59MP0001119_abnormal_female_reproductive0.49973708
60MP0002019_abnormal_tumor_incidence0.46026724
61MP0003011_delayed_dark_adaptation0.44481673
62MP0000749_muscle_degeneration0.43612563
63MP0009333_abnormal_splenocyte_physiolog0.43033557
64MP0003718_maternal_effect0.42957428
65MP0001697_abnormal_embryo_size0.42300320
66MP0008995_early_reproductive_senescence0.42090820
67MP0008775_abnormal_heart_ventricle0.41309921
68MP0005319_abnormal_enzyme/_coenzyme0.40897463
69MP0000689_abnormal_spleen_morphology0.40616125
70MP0005623_abnormal_meninges_morphology0.39418647
71MP0008872_abnormal_physiological_respon0.38593910
72MP0003283_abnormal_digestive_organ0.37832892
73MP0005174_abnormal_tail_pigmentation0.37359709
74MP0002722_abnormal_immune_system0.35255710
75MP0001672_abnormal_embryogenesis/_devel0.34829019
76MP0005380_embryogenesis_phenotype0.34829019
77MP0000703_abnormal_thymus_morphology0.34804638
78MP0002429_abnormal_blood_cell0.34114815
79MP0003950_abnormal_plasma_membrane0.32992905
80MP0005266_abnormal_metabolism0.32431505
81MP0001324_abnormal_eye_pigmentation0.30289545
82MP0002234_abnormal_pharynx_morphology0.29814406
83MP0002405_respiratory_system_inflammati0.29731664
84MP0005377_hearing/vestibular/ear_phenot0.29505965
85MP0003878_abnormal_ear_physiology0.29505965
86MP0003984_embryonic_growth_retardation0.26965768
87MP0009697_abnormal_copulation0.26713164
88MP0008469_abnormal_protein_level0.26449119
89MP0002169_no_abnormal_phenotype0.24026288
90MP0003115_abnormal_respiratory_system0.23927220
91MP0002873_normal_phenotype0.23662365
92MP0005376_homeostasis/metabolism_phenot0.23105337
93MP0002088_abnormal_embryonic_growth/wei0.22804361
94MP0005075_abnormal_melanosome_morpholog0.22047593
95MP0002085_abnormal_embryonic_tissue0.21589498
96MP0005584_abnormal_enzyme/coenzyme_acti0.21500011
97MP0001661_extended_life_span0.21139253
98MP0004134_abnormal_chest_morphology0.20175360
99MP0008789_abnormal_olfactory_epithelium0.19875162
100MP0002139_abnormal_hepatobiliary_system0.19402816

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)8.41269758
2Abnormal respiratory epithelium morphology (HP:0012253)8.41269758
3Abnormal respiratory motile cilium physiology (HP:0012261)8.12388772
4Rhinitis (HP:0012384)6.65776186
5Abnormality of the heme biosynthetic pathway (HP:0010472)6.52276199
6Abnormal ciliary motility (HP:0012262)6.47404307
7Chronic bronchitis (HP:0004469)6.41999609
8Nasal polyposis (HP:0100582)5.67168817
9Infertility (HP:0000789)5.55639245
10Abnormality of the nasal mucosa (HP:0000433)4.68054629
11Abnormal spermatogenesis (HP:0008669)4.12163947
12Bronchitis (HP:0012387)4.06019771
13Bronchiectasis (HP:0002110)3.85904786
14Abnormal number of erythroid precursors (HP:0012131)3.81617943
15Nephronophthisis (HP:0000090)3.65535328
16Male infertility (HP:0003251)3.64708743
17Abnormality of cells of the erythroid lineage (HP:0012130)3.45160264
18Recurrent sinusitis (HP:0011108)3.29999458
19Recurrent otitis media (HP:0000403)3.10400463
20Azoospermia (HP:0000027)2.96381648
21Poikilocytosis (HP:0004447)2.87321288
22Tubulointerstitial nephritis (HP:0001970)2.78649756
23Abnormal gallbladder physiology (HP:0012438)2.77408539
24Cholecystitis (HP:0001082)2.77408539
25Abnormality of the renal medulla (HP:0100957)2.68945542
26Hypoplasia of the capital femoral epiphysis (HP:0003090)2.67504944
27Impulsivity (HP:0100710)2.67344054
28Medial flaring of the eyebrow (HP:0010747)2.53966548
29Reticulocytosis (HP:0001923)2.53901726
30Recurrent bronchitis (HP:0002837)2.48699879
31Molar tooth sign on MRI (HP:0002419)2.45384400
32Abnormality of midbrain morphology (HP:0002418)2.45384400
33Absent epiphyses (HP:0010577)2.37542273
34Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.37542273
35Acanthocytosis (HP:0001927)2.23896874
36Tongue fasciculations (HP:0001308)2.17732706
37Tubulointerstitial abnormality (HP:0001969)2.08697132
38Cerebellar dysplasia (HP:0007033)2.08304534
39Dynein arm defect of respiratory motile cilia (HP:0012255)11.9080199
40Absent/shortened dynein arms (HP:0200106)11.9080199
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.7407697
42Abnormality of reticulocytes (HP:0004312)1.97358372
43Irregular epiphyses (HP:0010582)1.94762102
44Tubular atrophy (HP:0000092)1.94714553
45Muscle fibrillation (HP:0010546)1.91067160
46Gonadotropin excess (HP:0000837)1.88727129
47Birth length less than 3rd percentile (HP:0003561)1.87591684
48Diaphragmatic weakness (HP:0009113)1.86838726
49Postaxial foot polydactyly (HP:0001830)1.80145467
50Abnormal biliary tract physiology (HP:0012439)1.73003576
51Bile duct proliferation (HP:0001408)1.73003576
52Pancreatic fibrosis (HP:0100732)1.71722588
53Facial cleft (HP:0002006)1.67269939
54Short ribs (HP:0000773)1.65177280
55Spastic tetraparesis (HP:0001285)1.64774594
56Decreased activity of mitochondrial respiratory chain (HP:0008972)1.63393693
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.63393693
58Chronic sinusitis (HP:0011109)1.56066151
59Congenital primary aphakia (HP:0007707)1.53226919
60Congenital hepatic fibrosis (HP:0002612)1.53100938
61Insomnia (HP:0100785)1.51519795
62Type 2 muscle fiber atrophy (HP:0003554)1.51251101
63Gait imbalance (HP:0002141)1.48366528
64Ileus (HP:0002595)1.47740393
65Pallor (HP:0000980)1.47194606
66Dyschromatopsia (HP:0007641)1.47094031
67Decreased central vision (HP:0007663)1.46702199
68Abnormality of the renal cortex (HP:0011035)1.44942858
69Short femoral neck (HP:0100864)1.44850584
70Tubulointerstitial fibrosis (HP:0005576)1.41794950
71Sloping forehead (HP:0000340)1.41144070
72Duodenal stenosis (HP:0100867)1.40104441
73Small intestinal stenosis (HP:0012848)1.40104441
74Cholelithiasis (HP:0001081)1.39816816
75Abnormal drinking behavior (HP:0030082)1.39468020
76Polydipsia (HP:0001959)1.39468020
77Abnormality of renal excretion (HP:0011036)1.37818147
78Pendular nystagmus (HP:0012043)1.37605656
79Constricted visual fields (HP:0001133)1.36926747
80Heterotopia (HP:0002282)1.35520508
81Oculomotor apraxia (HP:0000657)1.34936901
82Hyperbilirubinemia (HP:0002904)1.34839848
83Cleft eyelid (HP:0000625)1.33807318
84Optic nerve hypoplasia (HP:0000609)1.33605970
85Stage 5 chronic kidney disease (HP:0003774)1.32226576
86Muscle fiber atrophy (HP:0100295)1.31244642
87Pancytopenia (HP:0001876)1.29959497
88Type II lissencephaly (HP:0007260)1.28951868
89Nephrogenic diabetes insipidus (HP:0009806)1.28519340
90Postaxial hand polydactyly (HP:0001162)1.28117395
91True hermaphroditism (HP:0010459)1.26968148
92Aplasia/Hypoplasia of the uvula (HP:0010293)1.26303909
93Abnormality of the preputium (HP:0100587)1.25433144
94Personality changes (HP:0000751)1.25220574
95Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.25182824
96Severe visual impairment (HP:0001141)1.24420936
97Median cleft lip (HP:0000161)1.22400774
98Fibular hypoplasia (HP:0003038)1.22095046
99Aplastic anemia (HP:0001915)1.22065684
100Nephroblastoma (Wilms tumor) (HP:0002667)1.22040120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.24593935
2PDK38.24593935
3PDK25.24057570
4TESK14.75145035
5PRKD33.35182420
6ICK3.09131371
7EIF2AK12.25517923
8NEK22.23052044
9WEE11.91476418
10CDC71.86578346
11BRSK21.73344897
12WNK41.61657145
13DYRK31.61079487
14PTK2B1.60792628
15PNCK1.59597984
16STK161.46298671
17BUB11.35965470
18STK391.34149469
19DYRK1B1.13292506
20BRSK11.12598233
21PLK41.12262814
22TTK1.08006610
23NME21.04351463
24CHEK21.01420703
25STK380.95177796
26NEK10.92383072
27VRK10.92118830
28CCNB10.91812734
29PDK10.84484978
30PLK10.82105761
31ATR0.79655522
32TESK20.74487509
33CHEK10.71517963
34PINK10.68637089
35PASK0.68204821
36SRPK10.63259598
37STK100.62697498
38SCYL20.61204369
39ACVR1B0.59692217
40ATM0.59421305
41PIM20.59087252
42STK30.56760082
43EIF2AK30.56283140
44IRAK10.53112922
45MUSK0.51697919
46AURKA0.51320100
47MAPKAPK50.50204897
48AURKB0.49828457
49PIM10.47277479
50PAK10.46221993
51RPS6KA40.45877790
52EEF2K0.44564549
53NME10.42282852
54PBK0.40827823
55CDK40.40753170
56CSNK2A10.37889901
57MAP2K60.37226404
58CSNK2A20.36251361
59LMTK20.34785906
60CDK190.33084310
61MAP3K100.32055935
62TLK10.30001214
63PDPK10.29044561
64WNK10.25490742
65EIF2AK20.25443467
66CDK70.24912286
67PRKCG0.24349662
68CLK10.23696107
69KDR0.23080358
70STK38L0.23072645
71CDK20.22996315
72MARK30.21782149
73BRAF0.19713144
74MAP2K70.19534422
75PLK30.19068857
76MAP3K80.18669337
77MAPK150.17188274
78CDK10.17110852
79CDK11A0.15488683
80PAK20.15369889
81CDK150.14936251
82GRK10.14582852
83ABL20.14148490
84NEK60.14085089
85RPS6KB10.14062430
86YES10.11448261
87MAP3K50.11022964
88CDK180.10983453
89STK40.10706050
90PAK40.09616968
91PRKDC0.09416913
92IRAK20.09300410
93PRKAA10.08058984
94RPS6KA10.07115713
95MAP4K10.06727124
96CDK60.06139939
97ZAP700.05662936
98PRKCD0.05645846
99CDK140.05571391
100PRKACG0.04236820

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.98652359
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.22737351
3Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.14638307
4Basal transcription factors_Homo sapiens_hsa030222.78551410
5Vitamin B6 metabolism_Homo sapiens_hsa007502.68104262
6Pyruvate metabolism_Homo sapiens_hsa006202.67769804
7Fatty acid biosynthesis_Homo sapiens_hsa000612.55308087
8Proteasome_Homo sapiens_hsa030502.44004384
9Fanconi anemia pathway_Homo sapiens_hsa034602.41720446
10RNA transport_Homo sapiens_hsa030132.39320067
11Pyrimidine metabolism_Homo sapiens_hsa002402.33311607
12Mismatch repair_Homo sapiens_hsa034302.31282882
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27755772
14Selenocompound metabolism_Homo sapiens_hsa004502.08471367
15Ribosome_Homo sapiens_hsa030102.06708383
16Huntingtons disease_Homo sapiens_hsa050162.02376709
17Linoleic acid metabolism_Homo sapiens_hsa005911.97746996
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.94119750
19Homologous recombination_Homo sapiens_hsa034401.93269901
20Pentose phosphate pathway_Homo sapiens_hsa000301.92989229
21Purine metabolism_Homo sapiens_hsa002301.91523084
22Spliceosome_Homo sapiens_hsa030401.83141271
23Base excision repair_Homo sapiens_hsa034101.78364314
24Propanoate metabolism_Homo sapiens_hsa006401.77844773
25Nucleotide excision repair_Homo sapiens_hsa034201.71305538
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.66026527
27Non-homologous end-joining_Homo sapiens_hsa034501.63068009
28Oocyte meiosis_Homo sapiens_hsa041141.61919808
29Cell cycle_Homo sapiens_hsa041101.60736278
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55857598
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.54014045
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.47922824
33Glutathione metabolism_Homo sapiens_hsa004801.37412845
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.35256625
35RNA polymerase_Homo sapiens_hsa030201.34464013
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30113186
37RNA degradation_Homo sapiens_hsa030181.29769833
38Carbon metabolism_Homo sapiens_hsa012001.26517583
39Cardiac muscle contraction_Homo sapiens_hsa042601.26362310
40Parkinsons disease_Homo sapiens_hsa050121.25670584
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25246804
42mRNA surveillance pathway_Homo sapiens_hsa030151.24147000
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22063442
44Glucagon signaling pathway_Homo sapiens_hsa049221.17698088
45Oxidative phosphorylation_Homo sapiens_hsa001901.16447896
46Systemic lupus erythematosus_Homo sapiens_hsa053221.15881261
47Antigen processing and presentation_Homo sapiens_hsa046121.08835345
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04182555
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00315546
50Biosynthesis of amino acids_Homo sapiens_hsa012300.94638911
51Fructose and mannose metabolism_Homo sapiens_hsa000510.92355731
52One carbon pool by folate_Homo sapiens_hsa006700.90655697
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88474729
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.84050665
55Sulfur relay system_Homo sapiens_hsa041220.83873890
56Mineral absorption_Homo sapiens_hsa049780.82159538
57Glycerolipid metabolism_Homo sapiens_hsa005610.82075546
58p53 signaling pathway_Homo sapiens_hsa041150.81334054
59Metabolic pathways_Homo sapiens_hsa011000.79524330
60Ether lipid metabolism_Homo sapiens_hsa005650.79022509
61Legionellosis_Homo sapiens_hsa051340.75505418
62Fat digestion and absorption_Homo sapiens_hsa049750.74621818
63ABC transporters_Homo sapiens_hsa020100.71372825
64PPAR signaling pathway_Homo sapiens_hsa033200.69606664
65Arachidonic acid metabolism_Homo sapiens_hsa005900.63633593
66N-Glycan biosynthesis_Homo sapiens_hsa005100.63150939
67Alzheimers disease_Homo sapiens_hsa050100.62566910
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59815460
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59463577
70Fatty acid degradation_Homo sapiens_hsa000710.58027986
71Epstein-Barr virus infection_Homo sapiens_hsa051690.55534101
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53956581
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53350612
74Protein export_Homo sapiens_hsa030600.48543494
75Renin-angiotensin system_Homo sapiens_hsa046140.46740584
76Herpes simplex infection_Homo sapiens_hsa051680.43626788
77Fatty acid metabolism_Homo sapiens_hsa012120.41301082
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38814223
79Viral carcinogenesis_Homo sapiens_hsa052030.37846840
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36921456
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36288197
82Protein digestion and absorption_Homo sapiens_hsa049740.35456280
83Alcoholism_Homo sapiens_hsa050340.34837374
84Dorso-ventral axis formation_Homo sapiens_hsa043200.32396056
85Chemical carcinogenesis_Homo sapiens_hsa052040.30911782
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.27389108
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26083974
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.24203245
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22824668
90Amphetamine addiction_Homo sapiens_hsa050310.20697660
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19430951
92Sulfur metabolism_Homo sapiens_hsa009200.19275346
93Hematopoietic cell lineage_Homo sapiens_hsa046400.18115640
94Sphingolipid metabolism_Homo sapiens_hsa006000.17780738
95AMPK signaling pathway_Homo sapiens_hsa041520.15746184
96Measles_Homo sapiens_hsa051620.14592788
97Inositol phosphate metabolism_Homo sapiens_hsa005620.14562988
98Vitamin digestion and absorption_Homo sapiens_hsa049770.11178863
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.10846356
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.10808550

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