ASB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.32390167
2cardiac myofibril assembly (GO:0055003)8.48416021
3actin-myosin filament sliding (GO:0033275)8.43215683
4muscle filament sliding (GO:0030049)8.43215683
5myofibril assembly (GO:0030239)8.02836642
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.68626521
7regulation of skeletal muscle contraction (GO:0014819)7.00472804
8actin-mediated cell contraction (GO:0070252)6.95137033
9negative regulation of potassium ion transmembrane transport (GO:1901380)6.91693120
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.91122988
11cardiac muscle contraction (GO:0060048)6.78326250
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.58941546
13cardiac muscle cell development (GO:0055013)6.27022714
14tricarboxylic acid cycle (GO:0006099)6.20261698
15regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.03817675
16regulation of actin filament-based movement (GO:1903115)6.02840989
17regulation of relaxation of muscle (GO:1901077)6.00515554
18plasma membrane repair (GO:0001778)5.99927585
19sarcoplasmic reticulum calcium ion transport (GO:0070296)5.96497841
20actomyosin structure organization (GO:0031032)5.96450640
21cardiac cell development (GO:0055006)5.88313785
22striated muscle contraction (GO:0006941)5.84713936
23cardiac muscle tissue morphogenesis (GO:0055008)5.64059156
24carnitine shuttle (GO:0006853)5.52180636
25skeletal muscle fiber development (GO:0048741)5.48926834
26regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.48247078
27regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.42323207
28adult heart development (GO:0007512)5.41470291
29cardiac muscle hypertrophy (GO:0003300)5.38647722
30regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.28149183
31regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.27248964
32ventricular cardiac muscle cell action potential (GO:0086005)5.26009067
33actin filament-based movement (GO:0030048)5.24639659
34regulation of cell communication by electrical coupling (GO:0010649)5.23558714
35heart process (GO:0003015)5.21726263
36heart contraction (GO:0060047)5.21726263
37ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.21164878
38regulation of sarcomere organization (GO:0060297)5.21061988
39striated muscle hypertrophy (GO:0014897)5.16577847
40muscle tissue morphogenesis (GO:0060415)5.12188267
41heart trabecula formation (GO:0060347)5.03247229
42myotube cell development (GO:0014904)5.02528757
43regulation of striated muscle contraction (GO:0006942)4.99409073
44response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.98613044
45regulation of acyl-CoA biosynthetic process (GO:0050812)4.91428143
46bundle of His cell to Purkinje myocyte communication (GO:0086069)4.88730486
47fatty acid transmembrane transport (GO:1902001)4.74080450
48skeletal muscle contraction (GO:0003009)4.70030232
49glucan biosynthetic process (GO:0009250)4.62866299
50glycogen biosynthetic process (GO:0005978)4.62866299
51muscle hypertrophy (GO:0014896)4.58196212
52muscle fiber development (GO:0048747)4.56863133
53regulation of coenzyme metabolic process (GO:0051196)4.49226875
54regulation of cofactor metabolic process (GO:0051193)4.49226875
55regulation of membrane repolarization (GO:0060306)4.48729660
56glucan catabolic process (GO:0009251)4.45446150
57regulation of the force of heart contraction (GO:0002026)4.44186406
58creatine metabolic process (GO:0006600)4.37557376
59skeletal muscle tissue development (GO:0007519)4.32837427
60cellular polysaccharide catabolic process (GO:0044247)4.18478784
61response to inactivity (GO:0014854)4.16917800
62mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.15816701
63positive regulation of myotube differentiation (GO:0010831)4.15738383
64cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.13920287
65skeletal muscle adaptation (GO:0043501)4.12590013
66skeletal muscle tissue regeneration (GO:0043403)4.05806714
67cell communication involved in cardiac conduction (GO:0086065)4.03997741
68carnitine transmembrane transport (GO:1902603)4.03957810
69muscle hypertrophy in response to stress (GO:0003299)4.01295084
70cardiac muscle adaptation (GO:0014887)4.01295084
71cardiac muscle hypertrophy in response to stress (GO:0014898)4.01295084
72muscle cell cellular homeostasis (GO:0046716)4.00968032
73muscle contraction (GO:0006936)3.98753962
74positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.96339144
75oxidative phosphorylation (GO:0006119)3.94495233
76striated muscle adaptation (GO:0014888)3.88616359
77negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.86089347
78energy coupled proton transport, down electrochemical gradient (GO:0015985)3.83519249
79ATP synthesis coupled proton transport (GO:0015986)3.83519249
80regulation of cardiac muscle cell contraction (GO:0086004)3.82298187
81striated muscle cell development (GO:0055002)3.82230282
82regulation of cardiac muscle contraction (GO:0055117)3.81715709
83muscle adaptation (GO:0043500)3.81016053
842-oxoglutarate metabolic process (GO:0006103)3.79861025
85negative regulation of potassium ion transport (GO:0043267)3.78184558
86fructose metabolic process (GO:0006000)3.77822830
87regulation of ATPase activity (GO:0043462)3.77593410
88regulation of ATP catabolic process (GO:1903289)3.77593410
89NADH metabolic process (GO:0006734)3.75946919
90polysaccharide catabolic process (GO:0000272)3.75664493
91cardiac muscle cell action potential involved in contraction (GO:0086002)3.75441278
92gluconeogenesis (GO:0006094)3.75044079
93regulation of heart rate (GO:0002027)3.72333474
94muscle system process (GO:0003012)3.71705745
95cardiac muscle cell action potential (GO:0086001)3.71080915
96respiratory electron transport chain (GO:0022904)3.69758938
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.68892985
98amino-acid betaine transport (GO:0015838)3.66840834
99carnitine transport (GO:0015879)3.66840834
100glycogen metabolic process (GO:0005977)3.63351059
101negative regulation of protein localization to cell surface (GO:2000009)3.61347744
102regulation of sulfur metabolic process (GO:0042762)3.60390474
103negative regulation of striated muscle cell apoptotic process (GO:0010664)3.60123125
104electron transport chain (GO:0022900)3.58302967
105relaxation of cardiac muscle (GO:0055119)3.57974867
106glucan metabolic process (GO:0044042)3.57032766
107cellular glucan metabolic process (GO:0006073)3.57032766
108muscle organ development (GO:0007517)3.55104082
109regulation of cardioblast differentiation (GO:0051890)3.54551439
110muscle structure development (GO:0061061)3.53082901
111cell communication by electrical coupling (GO:0010644)3.49736500
112muscle cell fate commitment (GO:0042693)3.48626016
113positive regulation of cation channel activity (GO:2001259)3.47752412
114regulation of heart contraction (GO:0008016)3.46521515
115regulation of sequestering of triglyceride (GO:0010889)3.46426529
116glycogen catabolic process (GO:0005980)3.46205025
117regulation of calcium ion transmembrane transporter activity (GO:1901019)3.43913129
118regulation of calcium ion transmembrane transport (GO:1903169)3.43913129
119regulation of muscle contraction (GO:0006937)3.43703571
120regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.40723388
121response to muscle activity (GO:0014850)3.39451563
122striated muscle atrophy (GO:0014891)3.38943837
123negative regulation of necroptotic process (GO:0060546)3.37952298
124regulation of myoblast differentiation (GO:0045661)3.37706111
125negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.37376554
126negative regulation of calcium ion transmembrane transport (GO:1903170)3.37376554
127regulation of muscle system process (GO:0090257)3.33844757
128muscle atrophy (GO:0014889)3.33391900
129hexose biosynthetic process (GO:0019319)3.33321368
130response to activity (GO:0014823)3.31952930
131muscle cell development (GO:0055001)3.31199889
132muscle organ morphogenesis (GO:0048644)3.29672311
133oxaloacetate metabolic process (GO:0006107)3.28228099
134regulation of myotube differentiation (GO:0010830)3.22356325
135relaxation of muscle (GO:0090075)3.21770154
136cytidine metabolic process (GO:0046087)3.19967664
137cytidine catabolic process (GO:0006216)3.19967664
138cytidine deamination (GO:0009972)3.19967664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.56628816
2EP300_21415370_ChIP-Seq_HL-1_Mouse4.64085490
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.43350711
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.33548813
5* TBX20_22328084_ChIP-Seq_HEART_Mouse4.09133700
6* TBX20_22080862_ChIP-Seq_HEART_Mouse4.09133700
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.97573810
8ESR1_20079471_ChIP-ChIP_T-47D_Human3.31271678
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.29748638
10MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.10761445
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.04295005
12ZNF263_19887448_ChIP-Seq_K562_Human3.01694042
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.73755196
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.63246189
15GATA4_21415370_ChIP-Seq_HL-1_Mouse2.45823144
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.16045377
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.12189389
18EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.04609442
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.00078900
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.97473256
21CLOCK_20551151_ChIP-Seq_293T_Human1.87596185
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.87111555
23NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.84441381
24* MYC_22102868_ChIP-Seq_BL_Human1.78724827
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.77025785
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74546998
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72455511
28PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.66693606
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65793951
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60758490
31KDM2B_26808549_Chip-Seq_DND41_Human1.59947971
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.55162770
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52387190
34RUNX_20019798_ChIP-Seq_JUKART_Human1.50085064
35VDR_21846776_ChIP-Seq_THP-1_Human1.46671694
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45013219
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44296474
38CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.43495259
39BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.40441231
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39731328
41GATA1_22025678_ChIP-Seq_K562_Human1.38873720
42NFIB_24661679_ChIP-Seq_LUNG_Mouse1.36692391
43NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32799455
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28214088
45GATA1_19941826_ChIP-Seq_K562_Human1.28181514
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27904691
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.27671815
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25112463
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24076602
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22080309
51RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20761521
52* LXR_22158963_ChIP-Seq_LIVER_Mouse1.19136585
53CTCF_27219007_Chip-Seq_Bcells_Human1.16379150
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15530386
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15118099
56* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12903686
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10895731
58* LXR_22292898_ChIP-Seq_THP-1_Human1.10546166
59SPI1_20517297_ChIP-Seq_HL60_Human1.10464404
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10250965
61STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.07874619
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07628508
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07082708
64MYC_27129775_Chip-Seq_CORNEA_Mouse1.05068762
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04593884
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.04566367
67ISL1_27105846_Chip-Seq_CPCs_Mouse1.04360145
68* TP63_22573176_ChIP-Seq_HFKS_Human1.03665469
69SPI1_23127762_ChIP-Seq_K562_Human1.03365187
70RARB_27405468_Chip-Seq_BRAIN_Mouse1.03298358
71* TCF7_22412390_ChIP-Seq_EML_Mouse1.03133678
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.02795886
73* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02536816
74* RACK7_27058665_Chip-Seq_MCF-7_Human1.02316229
75* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02303387
76GATA2_19941826_ChIP-Seq_K562_Human1.01574098
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00230189
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99904077
79CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99301702
80EZH2_22144423_ChIP-Seq_EOC_Human0.98904681
81DROSHA_22980978_ChIP-Seq_HELA_Human0.98902641
82* RUNX1_27514584_Chip-Seq_MCF-7_Human0.98373253
83* MAF_26560356_Chip-Seq_TH2_Human0.97849357
84AR_21572438_ChIP-Seq_LNCaP_Human0.97685659
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97571326
86SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96431192
87* ATF3_27146783_Chip-Seq_COLON_Human0.96077726
88* SA1_27219007_Chip-Seq_Bcells_Human0.95466039
89RXR_22158963_ChIP-Seq_LIVER_Mouse0.94736724
90P68_20966046_ChIP-Seq_HELA_Human0.94228652
91GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92529901
92OCT4_20526341_ChIP-Seq_ESCs_Human0.92262565
93FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92048860
94CTCF_21964334_Chip-Seq_Bcells_Human0.91042689
95BCL6_27268052_Chip-Seq_Bcells_Human0.90062820
96SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89445405
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89102018
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88973856
99GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88618331
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88438208
101ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87199394
102* MAF_26560356_Chip-Seq_TH1_Human0.86037317
103GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85924164
104EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85761040
105SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85566953
106CTCF_26484167_Chip-Seq_Bcells_Mouse0.85366716
107BCOR_27268052_Chip-Seq_Bcells_Human0.84634187
108NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84593851
109CIITA_25753668_ChIP-Seq_RAJI_Human0.83818275
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.83184339
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82739140
112TRIM28_21343339_ChIP-Seq_HEK293_Human0.82612655
113SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82306350
114BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82081306
115SMC1_22415368_ChIP-Seq_MEFs_Mouse0.82009313
116CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81763727
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81698257
118* FOXH1_21741376_ChIP-Seq_ESCs_Human0.81609345
119FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81478962
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80825099
121FOXA2_19822575_ChIP-Seq_HepG2_Human0.80776277
122SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80694399
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.80004689
124STAT1_20625510_ChIP-Seq_HELA_Human0.79324614
125AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79130562
126CJUN_26792858_Chip-Seq_BT549_Human0.78851490
127* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78367557
128ESR1_21235772_ChIP-Seq_MCF-7_Human0.77751877
129VDR_24763502_ChIP-Seq_THP-1_Human0.77671397
130* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.77602157
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.76379199
132GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75898889
133DNAJC2_21179169_ChIP-ChIP_NT2_Human0.75448420
134SMC4_20622854_ChIP-Seq_HELA_Human0.75290075
135PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75257950
136CREB1_26743006_Chip-Seq_LNCaP_Human0.73254825

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.34102460
2MP0003646_muscle_fatigue5.83343503
3MP0004084_abnormal_cardiac_muscle5.51323519
4MP0000751_myopathy5.23638991
5MP0004036_abnormal_muscle_relaxation4.58714315
6MP0000749_muscle_degeneration4.49369333
7MP0004215_abnormal_myocardial_fiber4.31393325
8MP0005330_cardiomyopathy3.79015353
9MP0004145_abnormal_muscle_electrophysio3.37256828
10MP0004087_abnormal_muscle_fiber3.29636301
11MP0002972_abnormal_cardiac_muscle3.04881906
12MP0002106_abnormal_muscle_physiology2.93909860
13MP0005620_abnormal_muscle_contractility2.93562077
14MP0000750_abnormal_muscle_regeneration2.85832347
15MP0008775_abnormal_heart_ventricle2.74908577
16MP0004130_abnormal_muscle_cell2.67850210
17MP0003137_abnormal_impulse_conducting2.67320518
18MP0002269_muscular_atrophy2.62242813
19MP0010630_abnormal_cardiac_muscle2.57602119
20MP0005385_cardiovascular_system_phenoty2.48862226
21MP0001544_abnormal_cardiovascular_syste2.48862226
22MP0000747_muscle_weakness2.44259041
23MP0005369_muscle_phenotype2.36278467
24MP0000759_abnormal_skeletal_muscle2.32015784
25MP0004484_altered_response_of2.32014905
26MP0006138_congestive_heart_failure2.18617536
27MP0003828_pulmonary_edema2.14810220
28MP0004510_myositis2.09680684
29MP0003221_abnormal_cardiomyocyte_apopto2.01386767
30MP0004085_abnormal_heartbeat1.91989091
31MP0004233_abnormal_muscle_weight1.89321607
32MP0006036_abnormal_mitochondrial_physio1.79336474
33MP0002332_abnormal_exercise_endurance1.61827474
34MP0002127_abnormal_cardiovascular_syste1.54302224
35MP0003950_abnormal_plasma_membrane1.44264496
36MP0005666_abnormal_adipose_tissue1.41497188
37MP0003567_abnormal_fetal_cardiomyocyte1.24864092
38MP0000343_altered_response_to1.22018841
39MP0000266_abnormal_heart_morphology1.13286893
40MP0005670_abnormal_white_adipose1.13053430
41MP0004185_abnormal_adipocyte_glucose1.11132791
42MP0001661_extended_life_span1.04157031
43MP0006035_abnormal_mitochondrial_morpho1.01618684
44MP0002234_abnormal_pharynx_morphology1.00353757
45MP0004270_analgesia0.99105853
46MP0005375_adipose_tissue_phenotype0.96604199
47MP0002108_abnormal_muscle_morphology0.96519894
48MP0005165_increased_susceptibility_to0.96095953
49MP0003279_aneurysm0.95578356
50MP0000733_abnormal_muscle_development0.94401395
51MP0010368_abnormal_lymphatic_system0.87560234
52MP0005266_abnormal_metabolism0.84973828
53MP0000230_abnormal_systemic_arterial0.77255297
54MP0003806_abnormal_nucleotide_metabolis0.77114193
55MP0002128_abnormal_blood_circulation0.75886898
56MP0000372_irregular_coat_pigmentation0.75098640
57MP0003705_abnormal_hypodermis_morpholog0.72977002
58MP0003566_abnormal_cell_adhesion0.72659358
59MP0005451_abnormal_body_composition0.72225987
60MP0000685_abnormal_immune_system0.67719120
61MP0002971_abnormal_brown_adipose0.62676801
62MP0005623_abnormal_meninges_morphology0.59245757
63MP0000013_abnormal_adipose_tissue0.57503100
64MP0001879_abnormal_lymphatic_vessel0.55866469
65MP0000003_abnormal_adipose_tissue0.54513845
66MP0000767_abnormal_smooth_muscle0.54303815
67MP0004147_increased_porphyrin_level0.53823099
68MP0005645_abnormal_hypothalamus_physiol0.52970874
69MP0008961_abnormal_basal_metabolism0.52107210
70MP0001790_abnormal_immune_system0.50689342
71MP0005387_immune_system_phenotype0.50689342
72MP0008569_lethality_at_weaning0.50304584
73MP0003763_abnormal_thymus_physiology0.49268948
74MP0005319_abnormal_enzyme/_coenzyme0.49234321
75MP0005166_decreased_susceptibility_to0.49153611
76MP0002909_abnormal_adrenal_gland0.48145931
77MP0002078_abnormal_glucose_homeostasis0.46948299
78MP0004043_abnormal_pH_regulation0.46620175
79MP0002925_abnormal_cardiovascular_devel0.45841971
80MP0001800_abnormal_humoral_immune0.40585579
81MP0005671_abnormal_response_to0.38323707
82MP0001853_heart_inflammation0.36329107
83MP0003984_embryonic_growth_retardation0.35893462
84MP0002088_abnormal_embryonic_growth/wei0.35422601
85MP0004134_abnormal_chest_morphology0.35222313
86MP0008874_decreased_physiological_sensi0.35077894
87MP0001784_abnormal_fluid_regulation0.34971497
88MP0002166_altered_tumor_susceptibility0.34940931
89MP0003045_fibrosis0.34846626
90MP0004272_abnormal_basement_membrane0.34757408
91MP0001614_abnormal_blood_vessel0.34411735
92MP0003879_abnormal_hair_cell0.34028298
93MP0003948_abnormal_gas_homeostasis0.32638705
94MP0005334_abnormal_fat_pad0.32328503
95MP0009384_cardiac_valve_regurgitation0.31684856
96MP0005535_abnormal_body_temperature0.29389602
97MP0005275_abnormal_skin_tensile0.29253986
98MP0008438_abnormal_cutaneous_collagen0.28776671
99MP0005584_abnormal_enzyme/coenzyme_acti0.28322997
100MP0005187_abnormal_penis_morphology0.28090358
101MP0009672_abnormal_birth_weight0.27027955
102MP0001346_abnormal_lacrimal_gland0.26772969
103MP0000249_abnormal_blood_vessel0.26765719
104MP0005332_abnormal_amino_acid0.26422656
105MP0002138_abnormal_hepatobiliary_system0.25967397
106MP0001835_abnormal_antigen_presentation0.24594622
107MP0001727_abnormal_embryo_implantation0.24591405
108MP0009115_abnormal_fat_cell0.23298696
109MP0001299_abnormal_eye_distance/0.22906627
110MP0003303_peritoneal_inflammation0.22778221
111MP0004142_abnormal_muscle_tone0.22628489
112MP0009840_abnormal_foam_cell0.20841090
113MP0002118_abnormal_lipid_homeostasis0.20674804
114MP0005000_abnormal_immune_tolerance0.20358197
115MP0005595_abnormal_vascular_smooth0.20339472
116MP0005452_abnormal_adipose_tissue0.19571770
117MP0002822_catalepsy0.18675521
118MP0003656_abnormal_erythrocyte_physiolo0.17883558
119MP0002723_abnormal_immune_serum0.17302507
120MP0005376_homeostasis/metabolism_phenot0.16882095
121MP0003959_abnormal_lean_body0.16775121
122MP0002114_abnormal_axial_skeleton0.16530528
123MP0009780_abnormal_chondrocyte_physiolo0.16399707
124MP0002638_abnormal_pupillary_reflex0.16394700
125MP0005083_abnormal_biliary_tract0.16266318
126MP0002877_abnormal_melanocyte_morpholog0.15962170
127MP0002452_abnormal_antigen_presenting0.15025647
128MP0005167_abnormal_blood-brain_barrier0.14989465
129MP0002933_joint_inflammation0.14666340
130MP0005380_embryogenesis_phenotype0.13880922
131MP0001672_abnormal_embryogenesis/_devel0.13880922

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.55089770
2Exercise-induced myalgia (HP:0003738)7.11040416
3Exercise-induced muscle cramps (HP:0003710)7.08092317
4Calf muscle hypertrophy (HP:0008981)6.85926518
5Muscle hypertrophy of the lower extremities (HP:0008968)6.61783135
6Ventricular tachycardia (HP:0004756)6.31969423
7Muscle fiber splitting (HP:0003555)5.82955638
8Subaortic stenosis (HP:0001682)5.54519718
9Abnormality of the left ventricular outflow tract (HP:0011103)5.54519718
10Myoglobinuria (HP:0002913)5.46311231
11Abnormality of the calf musculature (HP:0001430)5.39843266
12Atrial fibrillation (HP:0005110)5.37362288
13Hyporeflexia of lower limbs (HP:0002600)5.29259584
14Primary atrial arrhythmia (HP:0001692)5.02793873
15Lipoatrophy (HP:0100578)4.94443529
16Supraventricular tachycardia (HP:0004755)4.86081219
17Supraventricular arrhythmia (HP:0005115)4.75932858
18EMG: myopathic abnormalities (HP:0003458)4.61721173
19Rhabdomyolysis (HP:0003201)4.33471054
20Right ventricular cardiomyopathy (HP:0011663)4.31907444
21Asymmetric septal hypertrophy (HP:0001670)4.24540875
22Syncope (HP:0001279)4.23618005
23Difficulty running (HP:0009046)4.16956236
24Increased connective tissue (HP:0009025)4.15447988
25Dilated cardiomyopathy (HP:0001644)4.12841431
26Bundle branch block (HP:0011710)4.09538191
27Muscle fiber inclusion bodies (HP:0100299)4.07145459
28Palpitations (HP:0001962)4.04566499
29Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.02143122
30Prolonged QT interval (HP:0001657)3.95515805
31Myotonia (HP:0002486)3.77845484
32Type 1 muscle fiber predominance (HP:0003803)3.74038997
33Ventricular arrhythmia (HP:0004308)3.73533158
34Calcaneovalgus deformity (HP:0001848)3.58443926
35Heart block (HP:0012722)3.45610954
36Ventricular fibrillation (HP:0001663)3.34754499
37Nemaline bodies (HP:0003798)3.32510779
38Atrioventricular block (HP:0001678)3.29084125
39Muscle stiffness (HP:0003552)3.26577017
40Absent phalangeal crease (HP:0006109)3.26206470
41Abnormal atrioventricular conduction (HP:0005150)3.24985593
42Difficulty climbing stairs (HP:0003551)3.16470939
43Deformed tarsal bones (HP:0008119)3.15383414
44Malignant hyperthermia (HP:0002047)2.93026779
45Abnormal EKG (HP:0003115)2.86371938
46Distal lower limb muscle weakness (HP:0009053)2.79262058
47Left ventricular hypertrophy (HP:0001712)2.77765360
48Areflexia of lower limbs (HP:0002522)2.77275770
49Neck muscle weakness (HP:0000467)2.77243418
50Increased variability in muscle fiber diameter (HP:0003557)2.71104414
51Abnormal finger flexion creases (HP:0006143)2.68829683
52Abnormality of skeletal muscle fiber size (HP:0012084)2.65955418
53Bulbar palsy (HP:0001283)2.65163431
54Abnormal mitochondria in muscle tissue (HP:0008316)2.62011435
55Hepatic necrosis (HP:0002605)2.55989437
56Acute necrotizing encephalopathy (HP:0006965)2.54030852
57Rimmed vacuoles (HP:0003805)2.45648995
58Limb-girdle muscle atrophy (HP:0003797)2.44371193
59Slender build (HP:0001533)2.43433318
60Ketoacidosis (HP:0001993)2.42836443
61Progressive muscle weakness (HP:0003323)2.40870480
62Distal arthrogryposis (HP:0005684)2.40784757
63Palmoplantar keratoderma (HP:0000982)2.39153779
64Round ear (HP:0100830)2.34922863
65Myopathic facies (HP:0002058)2.34269665
66Weak cry (HP:0001612)2.33490537
67Ragged-red muscle fibers (HP:0003200)2.27681475
68Fetal akinesia sequence (HP:0001989)2.26416384
69EMG: neuropathic changes (HP:0003445)2.26376875
70Hyperkalemia (HP:0002153)2.25810688
71Hepatocellular necrosis (HP:0001404)2.21551640
72Conjunctival hamartoma (HP:0100780)2.19401995
73Hypoglycemic coma (HP:0001325)2.18180628
74Abnormality of the neuromuscular junction (HP:0003398)2.17639943
75Fatigable weakness (HP:0003473)2.17639943
76Increased muscle lipid content (HP:0009058)2.17312771
77Acute encephalopathy (HP:0006846)2.17248215
78Exercise intolerance (HP:0003546)2.13752216
79Hypoplastic ischia (HP:0003175)2.12453116
80Generalized muscle weakness (HP:0003324)2.12442997
81Testicular atrophy (HP:0000029)2.12071280
82Mildly elevated creatine phosphokinase (HP:0008180)2.11739788
83Progressive macrocephaly (HP:0004481)2.09343895
84Muscular dystrophy (HP:0003560)2.08632008
85Abnormality of the calcaneus (HP:0008364)2.06613946
86Spinal rigidity (HP:0003306)2.06096949
87Mitochondrial inheritance (HP:0001427)2.05960087
88Facial diplegia (HP:0001349)2.05629863
89Abnormality of fatty-acid metabolism (HP:0004359)2.04390672
90Waddling gait (HP:0002515)2.03739971
91Hip contracture (HP:0003273)2.03665559
92Lower limb amyotrophy (HP:0007210)2.02975993
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02114817
94Dicarboxylic aciduria (HP:0003215)2.02114817
95Centrally nucleated skeletal muscle fibers (HP:0003687)1.99864924
96Cerebral edema (HP:0002181)1.99667616
97Distal lower limb amyotrophy (HP:0008944)1.99060247
98Abnormality of the foot musculature (HP:0001436)1.97903813
99Gowers sign (HP:0003391)1.97576557
100Sudden cardiac death (HP:0001645)1.96891480
101Increased CSF lactate (HP:0002490)1.96702285
102Scapular winging (HP:0003691)1.92702900
103Congestive heart failure (HP:0001635)1.91904926
104Abnormality of the shoulder girdle musculature (HP:0001435)1.91275950
105Ulnar deviation of the wrist (HP:0003049)1.89641541
106Increased intramyocellular lipid droplets (HP:0012240)1.89352095
107Pheochromocytoma (HP:0002666)1.86711014
108Foot dorsiflexor weakness (HP:0009027)1.84428291
109Abnormality of the ischium (HP:0003174)1.84047013
110Frequent falls (HP:0002359)1.83727023
111Large for gestational age (HP:0001520)1.83688468
112Lactic acidosis (HP:0003128)1.82901996
113Ketosis (HP:0001946)1.80012664
114Proximal amyotrophy (HP:0007126)1.79537708
115Abnormality of alanine metabolism (HP:0010916)1.78800011
116Hyperalaninemia (HP:0003348)1.78800011
117Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78800011
118Respiratory insufficiency due to muscle weakness (HP:0002747)1.77545431
119Double outlet right ventricle (HP:0001719)1.76319324
120Congenital malformation of the right heart (HP:0011723)1.76319324
121Abnormality of the musculature of the pelvis (HP:0001469)1.68658822
122Abnormality of the hip-girdle musculature (HP:0001445)1.68658822
123Pelvic girdle muscle weakness (HP:0003749)1.66631934
124Shoulder girdle muscle weakness (HP:0003547)1.62682336
125Paralysis (HP:0003470)1.58198734
126Limb-girdle muscle weakness (HP:0003325)1.56568337
127Nonprogressive disorder (HP:0003680)1.50760102
128Steppage gait (HP:0003376)1.49855504
129Long clavicles (HP:0000890)1.45934333
130Metatarsus adductus (HP:0001840)1.45367745
131Type 2 muscle fiber atrophy (HP:0003554)1.44859976
132Oligomenorrhea (HP:0000876)1.38510999
133Popliteal pterygium (HP:0009756)1.38229643

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.26178110
2OBSCN5.34618906
3PHKG24.53591799
4PHKG14.53591799
5MYLK3.54428284
6DMPK3.13927082
7LMTK23.07917139
8PKN23.03646488
9PDK43.03620787
10PDK33.03620787
11TRIB32.77645697
12PIK3CA2.34347775
13STK242.26999003
14BCKDK2.25104854
15NEK12.20953115
16MUSK1.97596722
17PINK11.85764486
18PDK21.81312116
19TIE11.64845539
20MAP3K71.41648796
21MAP2K31.41073101
22PRPF4B1.35982111
23GRK71.25941273
24ILK1.22534897
25MAPK121.22194607
26NME11.21615559
27MAP3K131.16860102
28PRKD11.13366482
29PAK31.04008002
30CAMK2D1.02697338
31TRPM70.97793943
32CDC42BPA0.95520784
33PRKAA20.92108972
34MAPKAPK30.91632929
35PRKAA10.90459912
36ZAK0.88463816
37ROCK10.87035644
38FLT30.85788862
39CCNB10.82630375
40STK40.80758682
41MAP3K50.80006814
42PIK3CG0.79338687
43RIPK10.78887173
44TGFBR20.78869479
45LIMK10.74420464
46PKN10.74341512
47MOS0.72448768
48EPHB10.71374037
49STK38L0.70034286
50MARK10.68050119
51MAP3K30.66440855
52MAPK40.65765785
53NEK90.62897025
54DAPK30.62090282
55WNK40.61617993
56CAMK40.60087153
57INSRR0.58885253
58DYRK1B0.58883726
59KSR20.56329448
60KDR0.54504772
61JAK10.50357691
62PDGFRA0.47879905
63ROCK20.47594079
64RPS6KC10.46517401
65RPS6KL10.46517401
66SYK0.46466934
67PTK2B0.45246560
68PRKACB0.44865615
69PTK60.44075323
70WNK10.43892686
71MAP3K100.42759699
72CAMK2A0.41049531
73SIK10.40415856
74RPS6KA60.40121630
75CAMK10.39899138
76RIPK40.39053489
77CAMK2G0.38688262
78MAP2K10.38380545
79STK380.36624189
80EPHA30.35507377
81PDK10.35360677
82MAP3K140.35224901
83PDPK10.35119810
84TAOK20.35073302
85ARAF0.34817540
86MAP2K60.34775599
87PRKACA0.32701735
88AKT20.32458073
89BLK0.32361808
90PRKACG0.31761353
91ICK0.31528571
92MAP2K40.31139645
93MAP3K10.30262501
94RPS6KB20.29649031
95MAPK110.29392231
96PRKCH0.28431534
97CAMK2B0.28399919
98ERN10.27175341
99RPS6KA10.26491275
100SGK20.26453841
101FGFR40.26337221
102CDK190.26263917
103TYK20.25363632
104MARK30.24893445
105LRRK20.24347735
106MAP4K10.21841327
107EIF2AK30.21039411
108ERBB30.20744798
109PRKCE0.20591374
110SGK30.19732554
111JAK20.19404088
112EEF2K0.19148988
113PRKG10.18506717
114MARK20.18276595
115TBK10.18195399
116MAP3K90.17932588
117MTOR0.17818708
118RET0.17330882
119MAPK100.16215905
120MAPK70.16022195
121SGK10.15764381
122PRKCQ0.15581149
123MAP3K110.15437686
124ZAP700.15398578
125TAOK10.15190242
126FGFR30.14758257
127RPS6KB10.14471838
128RPS6KA30.14101455
129STK390.14029576
130MAPKAPK20.13179865

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.82333633
2Cardiac muscle contraction_Homo sapiens_hsa042604.40501349
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.23825441
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.95202269
5Dilated cardiomyopathy_Homo sapiens_hsa054143.89305575
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.19040316
7Propanoate metabolism_Homo sapiens_hsa006403.05040389
8Parkinsons disease_Homo sapiens_hsa050123.02696654
9Oxidative phosphorylation_Homo sapiens_hsa001902.83187356
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.67451188
11Fatty acid degradation_Homo sapiens_hsa000712.63685031
12Carbon metabolism_Homo sapiens_hsa012002.48149455
13Alzheimers disease_Homo sapiens_hsa050102.25785963
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.15436142
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05591525
16Fatty acid metabolism_Homo sapiens_hsa012121.97382619
17Viral myocarditis_Homo sapiens_hsa054161.88062904
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.83161416
19Huntingtons disease_Homo sapiens_hsa050161.78429477
20Pyruvate metabolism_Homo sapiens_hsa006201.69024292
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.43790008
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34871412
23Insulin resistance_Homo sapiens_hsa049311.31560644
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.31299578
25Starch and sucrose metabolism_Homo sapiens_hsa005001.30316523
26Glucagon signaling pathway_Homo sapiens_hsa049221.24354311
27Biosynthesis of amino acids_Homo sapiens_hsa012301.21971350
28Allograft rejection_Homo sapiens_hsa053301.19628160
29Adipocytokine signaling pathway_Homo sapiens_hsa049201.17149959
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12636805
31Primary immunodeficiency_Homo sapiens_hsa053401.12363884
32Insulin signaling pathway_Homo sapiens_hsa049101.11142096
33Butanoate metabolism_Homo sapiens_hsa006501.07768817
34Autoimmune thyroid disease_Homo sapiens_hsa053201.04653605
35Fatty acid elongation_Homo sapiens_hsa000621.01062850
36Graft-versus-host disease_Homo sapiens_hsa053320.95242946
37Asthma_Homo sapiens_hsa053100.93941319
38B cell receptor signaling pathway_Homo sapiens_hsa046620.92872305
39PPAR signaling pathway_Homo sapiens_hsa033200.92767824
40Systemic lupus erythematosus_Homo sapiens_hsa053220.90097865
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86796766
42Oxytocin signaling pathway_Homo sapiens_hsa049210.86502778
43Calcium signaling pathway_Homo sapiens_hsa040200.85483525
44HIF-1 signaling pathway_Homo sapiens_hsa040660.84553669
45AMPK signaling pathway_Homo sapiens_hsa041520.82886544
46Galactose metabolism_Homo sapiens_hsa000520.81577757
47Focal adhesion_Homo sapiens_hsa045100.81237447
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81071950
49Circadian rhythm_Homo sapiens_hsa047100.71974708
50Lysine degradation_Homo sapiens_hsa003100.70240192
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69410910
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.68503301
53Arginine biosynthesis_Homo sapiens_hsa002200.66241141
54Tryptophan metabolism_Homo sapiens_hsa003800.65854822
55Arginine and proline metabolism_Homo sapiens_hsa003300.65642957
56Type II diabetes mellitus_Homo sapiens_hsa049300.65063188
57Fructose and mannose metabolism_Homo sapiens_hsa000510.64915960
58Long-term potentiation_Homo sapiens_hsa047200.64073823
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.63429083
60Type I diabetes mellitus_Homo sapiens_hsa049400.62851696
61Tight junction_Homo sapiens_hsa045300.58037815
62beta-Alanine metabolism_Homo sapiens_hsa004100.56793527
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55074501
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48995098
65Leishmaniasis_Homo sapiens_hsa051400.47515478
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46674314
67Fatty acid biosynthesis_Homo sapiens_hsa000610.43116538
68Renin secretion_Homo sapiens_hsa049240.42160104
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41816648
70Gastric acid secretion_Homo sapiens_hsa049710.39618828
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.37934052
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37442731
73Adherens junction_Homo sapiens_hsa045200.37128534
74Phenylalanine metabolism_Homo sapiens_hsa003600.36646038
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36076955
76cAMP signaling pathway_Homo sapiens_hsa040240.34451343
77Amoebiasis_Homo sapiens_hsa051460.34396665
78Peroxisome_Homo sapiens_hsa041460.33590071
79T cell receptor signaling pathway_Homo sapiens_hsa046600.32354177
80Platelet activation_Homo sapiens_hsa046110.31091629
81ECM-receptor interaction_Homo sapiens_hsa045120.31086909
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30938579
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29624106
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.28262735
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28156287
86VEGF signaling pathway_Homo sapiens_hsa043700.26917914
87Antigen processing and presentation_Homo sapiens_hsa046120.26337623
88Influenza A_Homo sapiens_hsa051640.26252952
89Renal cell carcinoma_Homo sapiens_hsa052110.25633219
90mTOR signaling pathway_Homo sapiens_hsa041500.25529325
91Insulin secretion_Homo sapiens_hsa049110.23719482
92Toxoplasmosis_Homo sapiens_hsa051450.22821628
93FoxO signaling pathway_Homo sapiens_hsa040680.22742743
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22654774
95Alcoholism_Homo sapiens_hsa050340.21296642
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.20277079
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.19914839
98Proteoglycans in cancer_Homo sapiens_hsa052050.18681284
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.18555690
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18267606
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.18008330
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.17551325
103Pentose phosphate pathway_Homo sapiens_hsa000300.17398891
104Salivary secretion_Homo sapiens_hsa049700.16966030
105GnRH signaling pathway_Homo sapiens_hsa049120.16846616
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16512111
107Viral carcinogenesis_Homo sapiens_hsa052030.16147442
108Metabolic pathways_Homo sapiens_hsa011000.15688582
109Nitrogen metabolism_Homo sapiens_hsa009100.14573213
110Tuberculosis_Homo sapiens_hsa051520.14405902
111Non-small cell lung cancer_Homo sapiens_hsa052230.14318385
112HTLV-I infection_Homo sapiens_hsa051660.14140131
113Epstein-Barr virus infection_Homo sapiens_hsa051690.13514607
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.12395907
115MAPK signaling pathway_Homo sapiens_hsa040100.12193304
116Osteoclast differentiation_Homo sapiens_hsa043800.11585209
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.09968330
118Circadian entrainment_Homo sapiens_hsa047130.09878190
119Fat digestion and absorption_Homo sapiens_hsa049750.07461225
120Dorso-ventral axis formation_Homo sapiens_hsa043200.06887231
121Acute myeloid leukemia_Homo sapiens_hsa052210.05386388
122Notch signaling pathway_Homo sapiens_hsa043300.03197489
123Small cell lung cancer_Homo sapiens_hsa052220.02732856
124Cholinergic synapse_Homo sapiens_hsa047250.01900617
125Tyrosine metabolism_Homo sapiens_hsa003500.01674844
126Pancreatic secretion_Homo sapiens_hsa049720.00661586
127Fc epsilon RI signaling pathway_Homo sapiens_hsa04664-0.0260963
128Gap junction_Homo sapiens_hsa04540-0.0250870
129Jak-STAT signaling pathway_Homo sapiens_hsa04630-0.0170345
130Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0147158

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