ASB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA methylation (GO:0031167)5.82431034
2rRNA modification (GO:0000154)4.95336873
3indole-containing compound catabolic process (GO:0042436)4.62356614
4indolalkylamine catabolic process (GO:0046218)4.62356614
5tryptophan catabolic process (GO:0006569)4.62356614
6behavioral response to nicotine (GO:0035095)4.44855191
7kynurenine metabolic process (GO:0070189)4.37212632
8neural tube formation (GO:0001841)4.33989967
9indolalkylamine metabolic process (GO:0006586)4.29173081
10forebrain morphogenesis (GO:0048853)4.00112063
11regulation of hippo signaling (GO:0035330)3.96090617
12detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.90485624
13negative regulation of phagocytosis (GO:0050765)3.89880198
14negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.86663828
15negative regulation of translation, ncRNA-mediated (GO:0040033)3.86663828
16regulation of translation, ncRNA-mediated (GO:0045974)3.86663828
17tryptophan metabolic process (GO:0006568)3.84379949
18dendritic cell chemotaxis (GO:0002407)3.71466567
19purine deoxyribonucleotide catabolic process (GO:0009155)3.63154490
20L-fucose catabolic process (GO:0042355)3.60884048
21fucose catabolic process (GO:0019317)3.60884048
22L-fucose metabolic process (GO:0042354)3.60884048
23positive regulation of developmental pigmentation (GO:0048087)3.59342945
24protein K11-linked deubiquitination (GO:0035871)3.52400025
25regulation of activation of Janus kinase activity (GO:0010533)3.52199722
26base-excision repair, AP site formation (GO:0006285)3.47894163
27detection of light stimulus involved in visual perception (GO:0050908)3.47125191
28detection of light stimulus involved in sensory perception (GO:0050962)3.47125191
29cilium or flagellum-dependent cell motility (GO:0001539)3.45000431
30regulation of posttranscriptional gene silencing (GO:0060147)3.44792878
31regulation of gene silencing by miRNA (GO:0060964)3.44792878
32regulation of gene silencing by RNA (GO:0060966)3.44792878
33regulation of pigment cell differentiation (GO:0050932)3.42960282
34signal peptide processing (GO:0006465)3.42106419
35sulfation (GO:0051923)3.41516945
36regulation of DNA endoreduplication (GO:0032875)3.40544189
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.38728729
38interferon-gamma production (GO:0032609)3.33972151
39gamma-aminobutyric acid transport (GO:0015812)3.33675989
40establishment of protein localization to Golgi (GO:0072600)3.33175968
41neutrophil activation involved in immune response (GO:0002283)3.31454086
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.31050572
43indole-containing compound metabolic process (GO:0042430)3.30463933
44monoubiquitinated protein deubiquitination (GO:0035520)3.29095542
45photoreceptor cell maintenance (GO:0045494)3.26962561
46epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26575101
47snRNA transcription (GO:0009301)3.25055040
48reflex (GO:0060004)3.23651777
49interkinetic nuclear migration (GO:0022027)3.22826909
50oxidative demethylation (GO:0070989)3.19693688
51dendritic cell migration (GO:0036336)3.12065015
52natural killer cell activation involved in immune response (GO:0002323)3.09638940
53protein K48-linked deubiquitination (GO:0071108)3.09625435
54chaperone-mediated protein transport (GO:0072321)3.09551596
55regulation of relaxation of muscle (GO:1901077)3.08684119
56behavioral response to ethanol (GO:0048149)3.08517710
57negative regulation of cytosolic calcium ion concentration (GO:0051481)3.08078597
58negative regulation of mast cell activation (GO:0033004)3.06271518
59protein localization to cilium (GO:0061512)3.05984249
60retinal cone cell development (GO:0046549)3.05501571
61production of molecular mediator involved in inflammatory response (GO:0002532)3.02603084
62protein neddylation (GO:0045116)3.01415252
63cellular ketone body metabolic process (GO:0046950)2.99240853
64serotonin metabolic process (GO:0042428)2.98652810
65positive regulation of gamma-delta T cell activation (GO:0046645)2.94531850
66cornea development in camera-type eye (GO:0061303)2.94455253
67DNA ligation (GO:0006266)2.92763289
68regulation of establishment of cell polarity (GO:2000114)2.92537914
69cilium morphogenesis (GO:0060271)2.88920944
70regulation of sarcomere organization (GO:0060297)2.87747657
71cullin deneddylation (GO:0010388)2.86844474
72primary amino compound metabolic process (GO:1901160)2.81219111
737-methylguanosine mRNA capping (GO:0006370)2.80570769
74DNA topological change (GO:0006265)2.80084931
75neuronal action potential (GO:0019228)2.78591086
76polyketide metabolic process (GO:0030638)2.78515613
77doxorubicin metabolic process (GO:0044598)2.78515613
78daunorubicin metabolic process (GO:0044597)2.78515613
79epithelial cilium movement (GO:0003351)2.76926865
80cilium organization (GO:0044782)2.76225732
81cellular biogenic amine catabolic process (GO:0042402)2.75101593
82amine catabolic process (GO:0009310)2.75101593
83negative regulation of sodium ion transport (GO:0010766)2.72944128
84axoneme assembly (GO:0035082)2.72269367
85RNA capping (GO:0036260)2.72012437
867-methylguanosine RNA capping (GO:0009452)2.72012437
87thyroid hormone metabolic process (GO:0042403)2.71570349
88protein polyglutamylation (GO:0018095)2.71033720
89cilium assembly (GO:0042384)2.70774809
90cellular response to sterol (GO:0036315)2.70732855
91negative regulation of DNA-dependent DNA replication (GO:2000104)2.70268156
92ketone body metabolic process (GO:1902224)2.69752638
93protein K11-linked ubiquitination (GO:0070979)2.69274456
94spinal cord motor neuron differentiation (GO:0021522)2.68749068
95negative regulation of systemic arterial blood pressure (GO:0003085)2.68607149
96flavonoid metabolic process (GO:0009812)2.67925332
97RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.67671903
98tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.67671903
99positive regulation of oligodendrocyte differentiation (GO:0048714)2.66329511
100phospholipid translocation (GO:0045332)2.66297560
101lipid translocation (GO:0034204)2.66297560
102regulation of prostaglandin secretion (GO:0032306)2.65373088
103regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.65303351
104regulation of mitotic spindle checkpoint (GO:1903504)2.65303351
105response to pheromone (GO:0019236)2.65143991
106mitochondrial respiratory chain complex I assembly (GO:0032981)2.64902803
107NADH dehydrogenase complex assembly (GO:0010257)2.64902803
108mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64902803
109protein K63-linked deubiquitination (GO:0070536)2.64099434
110cilium movement (GO:0003341)2.63207796
111transmission of nerve impulse (GO:0019226)2.62468033
112central nervous system neuron axonogenesis (GO:0021955)2.60691115
113regulation of establishment or maintenance of cell polarity (GO:0032878)2.60397293
114benzene-containing compound metabolic process (GO:0042537)2.60322826
115tachykinin receptor signaling pathway (GO:0007217)2.60032052
116leukocyte degranulation (GO:0043299)2.59643749
117protein complex biogenesis (GO:0070271)2.59013944
118G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.58947312
119protein deneddylation (GO:0000338)2.57951144
120positive regulation of prostaglandin secretion (GO:0032308)2.57412412
121double-strand break repair via homologous recombination (GO:0000724)2.55813707
122regulation of collateral sprouting (GO:0048670)2.55566914
123appendage development (GO:0048736)2.54876077
124limb development (GO:0060173)2.54876077
125embryonic epithelial tube formation (GO:0001838)2.54850510
126recombinational repair (GO:0000725)2.54665491
127membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.54432548
128regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.54365892
129NAD biosynthetic process (GO:0009435)2.54228313
130kidney morphogenesis (GO:0060993)2.54223804
131positive regulation of protein homodimerization activity (GO:0090073)2.54211176
132detection of mechanical stimulus involved in sensory perception (GO:0050974)2.53962514
133histone H2A acetylation (GO:0043968)2.53256180
134startle response (GO:0001964)2.51561213
135DNA double-strand break processing (GO:0000729)2.51435799
136presynaptic membrane assembly (GO:0097105)2.50401684
137regulation of action potential (GO:0098900)2.50401336
138membrane depolarization during action potential (GO:0086010)2.49771177
139reciprocal meiotic recombination (GO:0007131)2.48508960
140reciprocal DNA recombination (GO:0035825)2.48508960
141protein prenylation (GO:0018342)2.47711065
142prenylation (GO:0097354)2.47711065
143mitochondrial respiratory chain complex assembly (GO:0033108)2.47544252
144histamine secretion (GO:0001821)2.46373372
145relaxation of smooth muscle (GO:0044557)2.44681425
146deoxyribonucleotide catabolic process (GO:0009264)2.43842071
147programmed necrotic cell death (GO:0097300)2.43670759
148photoreceptor cell development (GO:0042461)2.43382515
149respiratory burst (GO:0045730)2.43356367
150proline transport (GO:0015824)2.43200674
151CENP-A containing nucleosome assembly (GO:0034080)2.42077108
152pinocytosis (GO:0006907)2.41175977
153dopamine transport (GO:0015872)2.41114796
154positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.40393384
155cellular response to interleukin-15 (GO:0071350)2.39673773
156C-terminal protein lipidation (GO:0006501)2.34622746
157regulation of B cell receptor signaling pathway (GO:0050855)2.34494690
158positive regulation of alpha-beta T cell proliferation (GO:0046641)2.34400146
159nonmotile primary cilium assembly (GO:0035058)2.33000891
160necrotic cell death (GO:0070265)2.32535825
161C-terminal protein amino acid modification (GO:0018410)2.31289185
162RNA methylation (GO:0001510)2.30835292
163myeloid dendritic cell activation (GO:0001773)2.29832105
164G2 DNA damage checkpoint (GO:0031572)2.29329352
165positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.28973482
166positive regulation of natural killer cell differentiation (GO:0032825)2.28393572
167regulation of vitamin D biosynthetic process (GO:0060556)2.27643467
168protein targeting to mitochondrion (GO:0006626)2.27322444
169neutrophil activation (GO:0042119)2.27129070
170chromatin remodeling at centromere (GO:0031055)2.26394955
171deoxyribose phosphate catabolic process (GO:0046386)2.26052414
172regulation of T cell tolerance induction (GO:0002664)2.25937720
173positive regulation of interleukin-17 production (GO:0032740)2.25921922
174positive regulation of cellular response to oxidative stress (GO:1900409)2.25888839
175positive regulation of response to oxidative stress (GO:1902884)2.25888839
176T-helper 1 type immune response (GO:0042088)2.24428993
177attachment of spindle microtubules to kinetochore (GO:0008608)2.22932583
178retinal rod cell development (GO:0046548)2.22234778
179purine deoxyribonucleotide metabolic process (GO:0009151)2.21838175
180DNA-dependent DNA replication (GO:0006261)2.20991327
181negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.20848358
182leukocyte aggregation (GO:0070486)2.19849451
183regulation of alpha-beta T cell proliferation (GO:0046640)2.18965830
184transcription elongation from RNA polymerase II promoter (GO:0006368)2.18244439
185negative T cell selection (GO:0043383)2.18221931
186regulation of fibroblast apoptotic process (GO:2000269)2.17954934
187positive regulation of macrophage differentiation (GO:0045651)2.17118183
188replication fork processing (GO:0031297)2.16954663
189peptidyl-histidine modification (GO:0018202)2.16823760
190response to interleukin-15 (GO:0070672)2.16704593
191mast cell activation (GO:0045576)2.16544155
192spinal cord association neuron differentiation (GO:0021527)2.16491774
193telomere maintenance via semi-conservative replication (GO:0032201)2.16323512
194positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.16299899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.81130809
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.68523377
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.11297411
4ZNF274_21170338_ChIP-Seq_K562_Hela3.11095854
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.01313894
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.95304029
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.90501999
8VDR_22108803_ChIP-Seq_LS180_Human2.89550449
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88700733
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.79051300
11EZH2_22144423_ChIP-Seq_EOC_Human2.72301516
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.65376974
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.58752593
14IGF1R_20145208_ChIP-Seq_DFB_Human2.57863724
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.54135481
16ELK1_19687146_ChIP-ChIP_HELA_Human2.51456258
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.45845829
18TAF15_26573619_Chip-Seq_HEK293_Human2.41761824
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.35561733
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34292018
21HOXB4_20404135_ChIP-ChIP_EML_Mouse2.23832141
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.16973646
23* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16485697
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.15767167
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15395959
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.13790160
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.13696756
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.13183996
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09812552
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.09680353
31IRF1_19129219_ChIP-ChIP_H3396_Human2.07081855
32E2F7_22180533_ChIP-Seq_HELA_Human2.06632156
33* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.06101547
34CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04664636
35* FOXP3_21729870_ChIP-Seq_TREG_Human1.99696733
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.95905241
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93418144
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.93003758
39* STAT3_23295773_ChIP-Seq_U87_Human1.89440386
40SMAD4_21799915_ChIP-Seq_A2780_Human1.86811872
41VDR_23849224_ChIP-Seq_CD4+_Human1.85490226
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81703643
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.78985394
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77510599
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77107771
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74881215
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74766018
48FUS_26573619_Chip-Seq_HEK293_Human1.73909021
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73741235
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73466390
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73462554
52GBX2_23144817_ChIP-Seq_PC3_Human1.72897194
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68551376
54TCF4_23295773_ChIP-Seq_U87_Human1.68228212
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.66293937
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64688971
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64249369
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62703117
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62601054
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61980319
61BCAT_22108803_ChIP-Seq_LS180_Human1.59863835
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59799486
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59775028
64CBP_20019798_ChIP-Seq_JUKART_Human1.57834155
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57834155
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57089445
67AR_25329375_ChIP-Seq_VCAP_Human1.56329762
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56115066
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.55918993
70AR_21572438_ChIP-Seq_LNCaP_Human1.55593790
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55198362
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55198362
73* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47930170
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47294928
75EWS_26573619_Chip-Seq_HEK293_Human1.46730703
76STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46666149
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.45722170
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44529653
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43237103
80STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.41618190
81GATA1_22025678_ChIP-Seq_K562_Human1.39786991
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39749328
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39348644
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.39136796
85SALL4_22934838_ChIP-ChIP_CD34+_Human1.38847470
86TP53_16413492_ChIP-PET_HCT116_Human1.37800035
87TCF4_22108803_ChIP-Seq_LS180_Human1.35973682
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35647592
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35351455
90P300_19829295_ChIP-Seq_ESCs_Human1.35247560
91* RUNX2_22187159_ChIP-Seq_PCA_Human1.34658528
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32696133
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32315207
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32140041
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.31926201
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30259274
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29675114
98SPI1_23547873_ChIP-Seq_NB4_Human1.29246517
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.29041913
100* ETS1_20019798_ChIP-Seq_JURKAT_Human1.27118066
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.26989655
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26487158
103MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26294582
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25769251
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25150023
106REST_21632747_ChIP-Seq_MESCs_Mouse1.24313251
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.23648790
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23494643
109RNF2_27304074_Chip-Seq_NSC_Mouse1.22107659
110MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21795008
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.18785397
112SOX2_19829295_ChIP-Seq_ESCs_Human1.18690843
113NANOG_19829295_ChIP-Seq_ESCs_Human1.18690843
114RUNX_20019798_ChIP-Seq_JUKART_Human1.17786643
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16821104
116TP53_22573176_ChIP-Seq_HFKS_Human1.16314745
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.16227058
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15425686
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15348376
120AHR_22903824_ChIP-Seq_MCF-7_Human1.14197566
121THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14135918
122* SOX2_21211035_ChIP-Seq_LN229_Gbm1.13817914
123ER_23166858_ChIP-Seq_MCF-7_Human1.13497310
124BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13290084
125CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12625584
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12400252
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11792851
128CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11509644
129FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11428168
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.10540970
131* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09922985
132KDM2B_26808549_Chip-Seq_REH_Human1.09668086
133STAT3_18555785_Chip-Seq_ESCs_Mouse1.08598650
134P53_22387025_ChIP-Seq_ESCs_Mouse1.08569352
135CDX2_22108803_ChIP-Seq_LS180_Human1.07825394
136SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07052068
137E2F1_18555785_Chip-Seq_ESCs_Mouse1.06968081
138EZH2_27294783_Chip-Seq_NPCs_Mouse1.06858142
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05342423
140FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05062233
141TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04698595
142P300_18555785_Chip-Seq_ESCs_Mouse1.03917155
143DROSHA_22980978_ChIP-Seq_HELA_Human1.03571484
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03072456
145NANOG_18555785_Chip-Seq_ESCs_Mouse1.02500888
146FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02350574
147CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02339045
148OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01957278
149FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01806237
150IRF8_27001747_Chip-Seq_BMDM_Mouse1.01731780
151POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01340237
152RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01122217
153BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00542899
154EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00420713
155CMYC_18555785_Chip-Seq_ESCs_Mouse1.00079125
156NMYC_18555785_Chip-Seq_ESCs_Mouse0.99841513
157YY1_21170310_ChIP-Seq_MESCs_Mouse0.99318399
158ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99209748
159TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99051738
160GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98413656
161DCP1A_22483619_ChIP-Seq_HELA_Human0.98247709
162RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97988745
163PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97441517
164PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97152075
165GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96839079
166WT1_19549856_ChIP-ChIP_CCG9911_Human0.96548820
167GABP_19822575_ChIP-Seq_HepG2_Human0.95533896
168SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95397564
169RUNX1_27457419_Chip-Seq_LIVER_Mouse0.94284678
170VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94040155
171MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92430938
172MYB_26560356_Chip-Seq_TH2_Human0.91630571
173EGR1_19374776_ChIP-ChIP_THP-1_Human0.91347818
174TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90580871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.07303837
2MP0002009_preneoplasia3.32170816
3MP0009785_altered_susceptibility_to2.98422405
4MP0001835_abnormal_antigen_presentation2.94568770
5MP0005671_abnormal_response_to2.90900255
6MP0003787_abnormal_imprinting2.90090402
7MP0008877_abnormal_DNA_methylation2.89080335
8MP0008007_abnormal_cellular_replicative2.84404105
9MP0003195_calcinosis2.78642141
10MP0002132_abnormal_respiratory_system2.70641362
11MP0003724_increased_susceptibility_to2.59807016
12MP0001188_hyperpigmentation2.53931964
13MP0003646_muscle_fatigue2.42851056
14MP0002148_abnormal_hypersensitivity_rea2.41421193
15MP0009046_muscle_twitch2.38287677
16MP0002102_abnormal_ear_morphology2.27328071
17MP0009697_abnormal_copulation2.22597329
18MP0004043_abnormal_pH_regulation2.18083380
19MP0002166_altered_tumor_susceptibility2.08518430
20MP0002396_abnormal_hematopoietic_system2.06253733
21MP0010094_abnormal_chromosome_stability2.01352505
22MP0008057_abnormal_DNA_replication1.97052901
23MP0002006_tumorigenesis1.96018424
24MP0001501_abnormal_sleep_pattern1.92781066
25MP0000427_abnormal_hair_cycle1.88686125
26MP0005253_abnormal_eye_physiology1.87057585
27MP0003136_yellow_coat_color1.87035281
28MP0006292_abnormal_olfactory_placode1.83909417
29MP0005000_abnormal_immune_tolerance1.83829724
30MP0000685_abnormal_immune_system1.82063676
31MP0002877_abnormal_melanocyte_morpholog1.78660153
32MP0003890_abnormal_embryonic-extraembry1.78248876
33MP0001485_abnormal_pinna_reflex1.77882442
34MP0002420_abnormal_adaptive_immunity1.77394294
35MP0001819_abnormal_immune_cell1.76772293
36MP0003763_abnormal_thymus_physiology1.75212080
37MP0002163_abnormal_gland_morphology1.74922978
38MP0004142_abnormal_muscle_tone1.73724850
39MP0003880_abnormal_central_pattern1.73501390
40MP0006072_abnormal_retinal_apoptosis1.72223326
41MP0003221_abnormal_cardiomyocyte_apopto1.72040584
42MP0001486_abnormal_startle_reflex1.71000809
43MP0002723_abnormal_immune_serum1.70504999
44MP0002419_abnormal_innate_immunity1.69625947
45MP0001800_abnormal_humoral_immune1.69145235
46MP0002452_abnormal_antigen_presenting1.67481866
47MP0010386_abnormal_urinary_bladder1.66303182
48MP0002277_abnormal_respiratory_mucosa1.62808341
49MP0002837_dystrophic_cardiac_calcinosis1.61200413
50MP0002398_abnormal_bone_marrow1.60056981
51MP0000631_abnormal_neuroendocrine_gland1.59206325
52MP0002272_abnormal_nervous_system1.58312196
53MP0005025_abnormal_response_to1.56798981
54MP0001984_abnormal_olfaction1.50018441
55MP0000383_abnormal_hair_follicle1.49457366
56MP0005174_abnormal_tail_pigmentation1.49175423
57MP0000716_abnormal_immune_system1.45577291
58MP0005310_abnormal_salivary_gland1.43010860
59MP0002876_abnormal_thyroid_physiology1.40870740
60MP0008058_abnormal_DNA_repair1.39275687
61MP0002638_abnormal_pupillary_reflex1.37247104
62MP0003943_abnormal_hepatobiliary_system1.37110094
63MP0003121_genomic_imprinting1.36994184
64MP0002572_abnormal_emotion/affect_behav1.36204400
65MP0004145_abnormal_muscle_electrophysio1.35768741
66MP0004782_abnormal_surfactant_physiolog1.35490727
67MP0004924_abnormal_behavior1.34931348
68MP0005386_behavior/neurological_phenoty1.34931348
69MP0004808_abnormal_hematopoietic_stem1.34182892
70MP0005645_abnormal_hypothalamus_physiol1.33339452
71MP0003436_decreased_susceptibility_to1.30753220
72MP0004133_heterotaxia1.30300710
73MP0000778_abnormal_nervous_system1.27879184
74MP0003786_premature_aging1.26845235
75MP0005387_immune_system_phenotype1.26731508
76MP0001790_abnormal_immune_system1.26731508
77MP0002429_abnormal_blood_cell1.26676733
78MP0002928_abnormal_bile_duct1.25850898
79MP0002557_abnormal_social/conspecific_i1.25717248
80MP0003635_abnormal_synaptic_transmissio1.25021323
81MP0000689_abnormal_spleen_morphology1.24131359
82MP0001970_abnormal_pain_threshold1.21181391
83MP0002234_abnormal_pharynx_morphology1.20085664
84MP0002067_abnormal_sensory_capabilities1.19242227
85MP0001986_abnormal_taste_sensitivity1.16607394
86MP0003937_abnormal_limbs/digits/tail_de1.16278016
87MP0008961_abnormal_basal_metabolism1.15979307
88MP0004147_increased_porphyrin_level1.15931331
89MP0005397_hematopoietic_system_phenotyp1.15885877
90MP0001545_abnormal_hematopoietic_system1.15885877
91MP0002722_abnormal_immune_system1.15604894
92MP0005171_absent_coat_pigmentation1.12151157
93MP0006082_CNS_inflammation1.11272892
94MP0002736_abnormal_nociception_after1.10908331
95MP0003718_maternal_effect1.09871181
96MP0002733_abnormal_thermal_nociception1.09730093
97MP0002063_abnormal_learning/memory/cond1.09309217
98MP0001905_abnormal_dopamine_level1.08243308
99MP0005551_abnormal_eye_electrophysiolog1.07499220
100MP0000703_abnormal_thymus_morphology1.07316528
101MP0002734_abnormal_mechanical_nocicepti1.06594789
102MP0002160_abnormal_reproductive_system1.06030317
103MP0005464_abnormal_platelet_physiology1.05465382
104MP0004885_abnormal_endolymph1.04820266
105MP0005195_abnormal_posterior_eye1.04103208
106MP0002751_abnormal_autonomic_nervous1.04063771
107MP0004215_abnormal_myocardial_fiber1.02946413
108MP0003183_abnormal_peptide_metabolism1.02732757
109MP0003119_abnormal_digestive_system1.02357417
110MP0009764_decreased_sensitivity_to1.02000214
111MP0000372_irregular_coat_pigmentation1.01129817
112MP0003122_maternal_imprinting1.00836978
113MP0000538_abnormal_urinary_bladder1.00701548
114MP0003077_abnormal_cell_cycle0.98987982
115MP0002752_abnormal_somatic_nervous0.94149064
116MP0001529_abnormal_vocalization0.93113519
117MP0000681_abnormal_thyroid_gland0.92727228
118MP0003252_abnormal_bile_duct0.91907186
119MP0005389_reproductive_system_phenotype0.91715715
120MP0001293_anophthalmia0.91423338
121MP0002184_abnormal_innervation0.91328225
122MP0008260_abnormal_autophagy0.91175562
123MP0002653_abnormal_ependyma_morphology0.90359940
124MP0001324_abnormal_eye_pigmentation0.90203556
125MP0004130_abnormal_muscle_cell0.89386570
126MP0005670_abnormal_white_adipose0.89226878
127MP0003137_abnormal_impulse_conducting0.89200022
128MP0004742_abnormal_vestibular_system0.88661170
129MP0002095_abnormal_skin_pigmentation0.88585553
130MP0001845_abnormal_inflammatory_respons0.87771595
131MP0003878_abnormal_ear_physiology0.87358837
132MP0005377_hearing/vestibular/ear_phenot0.87358837
133MP0005084_abnormal_gallbladder_morpholo0.87309633
134MP0005187_abnormal_penis_morphology0.87103699
135MP0003698_abnormal_male_reproductive0.87003412
136MP0002229_neurodegeneration0.86461741
137MP0001346_abnormal_lacrimal_gland0.84870257
138MP0002882_abnormal_neuron_morphology0.82654520
139MP0000230_abnormal_systemic_arterial0.82630422
140MP0001968_abnormal_touch/_nociception0.82232214
141MP0001963_abnormal_hearing_physiology0.81591418
142MP0005646_abnormal_pituitary_gland0.81446773
143MP0000955_abnormal_spinal_cord0.80986237
144MP0000026_abnormal_inner_ear0.80633438
145MP0005379_endocrine/exocrine_gland_phen0.79901858
146MP0000858_altered_metastatic_potential0.79558217
147MP0000015_abnormal_ear_pigmentation0.79414667
148MP0009333_abnormal_splenocyte_physiolog0.79170460
149MP0008995_early_reproductive_senescence0.79076755
150MP0000647_abnormal_sebaceous_gland0.78172852
151MP0010155_abnormal_intestine_physiology0.77750450
152MP0001919_abnormal_reproductive_system0.77412975
153MP0005391_vision/eye_phenotype0.76852540
154MP0004085_abnormal_heartbeat0.74939261
155MP0002138_abnormal_hepatobiliary_system0.74908080
156MP0005266_abnormal_metabolism0.74192653
157MP0001186_pigmentation_phenotype0.73747065
158MP0000516_abnormal_urinary_system0.73534939
159MP0006035_abnormal_mitochondrial_morpho0.73212709
160MP0008872_abnormal_physiological_respon0.72396672
161MP0009765_abnormal_xenobiotic_induced0.71244532
162MP0008932_abnormal_embryonic_tissue0.71208625
163MP0009745_abnormal_behavioral_response0.71015010
164MP0002938_white_spotting0.70756720
165MP0002735_abnormal_chemical_nociception0.70543867
166MP0005408_hypopigmentation0.69871143
167MP0006276_abnormal_autonomic_nervous0.69298233
168MP0002405_respiratory_system_inflammati0.67720315
169MP0009763_increased_sensitivity_to0.66839476
170MP0002822_catalepsy0.66784099
171MP0003448_altered_tumor_morphology0.64398554
172MP0002064_seizures0.64339009

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)4.76282676
2Pancreatic cysts (HP:0001737)4.72240238
3Hyperventilation (HP:0002883)4.15814418
4Genetic anticipation (HP:0003743)4.06451188
5Aplastic anemia (HP:0001915)4.01260520
6Abnormality of midbrain morphology (HP:0002418)3.66194872
7Molar tooth sign on MRI (HP:0002419)3.66194872
8B lymphocytopenia (HP:0010976)3.65210601
9Abnormality of B cell number (HP:0010975)3.65210601
10Optic neuritis (HP:0100653)3.47276847
11Retrobulbar optic neuritis (HP:0100654)3.47276847
12Gaze-evoked nystagmus (HP:0000640)3.42367711
13Myositis (HP:0100614)3.41806445
14Severe visual impairment (HP:0001141)3.35465772
15Progressive cerebellar ataxia (HP:0002073)3.34955424
16Increased IgM level (HP:0003496)3.20942541
17Medial flaring of the eyebrow (HP:0010747)3.19331388
18Abnormality of the renal cortex (HP:0011035)3.18630890
19Abnormality of the renal medulla (HP:0100957)3.11044820
20Congenital primary aphakia (HP:0007707)3.09430105
21Nephrogenic diabetes insipidus (HP:0009806)3.08072468
22Cystic liver disease (HP:0006706)3.07308603
23Gait imbalance (HP:0002141)3.06090807
24Attenuation of retinal blood vessels (HP:0007843)3.05017607
25Chronic hepatic failure (HP:0100626)3.01449097
26Orchitis (HP:0100796)2.90148676
27Abnormality of T cell number (HP:0011839)2.85170297
28Microvesicular hepatic steatosis (HP:0001414)2.75975640
29Abolished electroretinogram (ERG) (HP:0000550)2.72287450
30Clumsiness (HP:0002312)2.72053628
31Volvulus (HP:0002580)2.68255708
32Type II lissencephaly (HP:0007260)2.66088730
33IgG deficiency (HP:0004315)2.64144795
34T lymphocytopenia (HP:0005403)2.62528021
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.62315845
36Broad-based gait (HP:0002136)2.59756496
37Fair hair (HP:0002286)2.58696201
38Inability to walk (HP:0002540)2.56019392
39Congenital sensorineural hearing impairment (HP:0008527)2.53074867
40True hermaphroditism (HP:0010459)2.52477654
41Abnormal hair whorl (HP:0010721)2.50780987
42Febrile seizures (HP:0002373)2.50692476
43Recurrent abscess formation (HP:0002722)2.47793156
44Generalized aminoaciduria (HP:0002909)2.47708678
45Aplasia/Hypoplasia of the tongue (HP:0010295)2.47687248
46Absent speech (HP:0001344)2.45200556
47Hypoplasia of the thymus (HP:0000778)2.40828208
483-Methylglutaconic aciduria (HP:0003535)2.40305967
49Tubular atrophy (HP:0000092)2.39293923
50Cerebellar dysplasia (HP:0007033)2.39108243
51Sclerocornea (HP:0000647)2.37459157
52Autoimmune hemolytic anemia (HP:0001890)2.36695103
53Congenital stationary night blindness (HP:0007642)2.35413989
54Cleft eyelid (HP:0000625)2.34228717
55Furrowed tongue (HP:0000221)2.32739512
56Progressive inability to walk (HP:0002505)2.30725644
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30111460
58Abnormality of alanine metabolism (HP:0010916)2.30111460
59Hyperalaninemia (HP:0003348)2.30111460
60Renal cortical cysts (HP:0000803)2.27798106
61Patellar aplasia (HP:0006443)2.27654103
62Congenital hepatic fibrosis (HP:0002612)2.26547019
63Bony spicule pigmentary retinopathy (HP:0007737)2.26290730
64Abnormality of T cells (HP:0002843)2.25620796
65Lissencephaly (HP:0001339)2.25507628
66Poor coordination (HP:0002370)2.25380458
67Recurrent bronchitis (HP:0002837)2.24691734
68Elevated erythrocyte sedimentation rate (HP:0003565)2.24653952
69Genital tract atresia (HP:0001827)2.24265245
70Decreased circulating renin level (HP:0003351)2.23841626
71Thrombocytosis (HP:0001894)2.23367411
72Spinal cord lesions (HP:0100561)2.22781256
73Syringomyelia (HP:0003396)2.22781256
74Anencephaly (HP:0002323)2.20983309
75Hepatosplenomegaly (HP:0001433)2.20032036
76Vaginal atresia (HP:0000148)2.17129246
77Large for gestational age (HP:0001520)2.17123254
78Nonprogressive disorder (HP:0003680)2.16625565
79Type I transferrin isoform profile (HP:0003642)2.16429999
80Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.16425836
81Progressive microcephaly (HP:0000253)2.14725964
82Abnormal drinking behavior (HP:0030082)2.13921844
83Polydipsia (HP:0001959)2.13921844
84Nephronophthisis (HP:0000090)2.12829111
85Aplasia/Hypoplasia of the patella (HP:0006498)2.12184991
86Keratoconjunctivitis sicca (HP:0001097)2.11839668
87Recurrent bacterial skin infections (HP:0005406)2.11320217
88Embryonal renal neoplasm (HP:0011794)2.08069033
89Lymphoma (HP:0002665)2.07855775
90Meningitis (HP:0001287)2.06686997
91Keratoconus (HP:0000563)2.06361276
92Increased corneal curvature (HP:0100692)2.06361276
93Widely spaced teeth (HP:0000687)2.05731016
94Postaxial foot polydactyly (HP:0001830)2.05011130
95Chronic diarrhea (HP:0002028)2.04990991
96Hypoplasia of the pons (HP:0012110)2.03782472
97Abnormality of the heme biosynthetic pathway (HP:0010472)2.03487642
98Small hand (HP:0200055)2.03332611
99Bile duct proliferation (HP:0001408)2.03066706
100Abnormal biliary tract physiology (HP:0012439)2.03066706
101Abnormality of the pons (HP:0007361)2.02080329
102Pancreatic fibrosis (HP:0100732)2.01143346
103Premature graying of hair (HP:0002216)1.99907905
104Alveolar cell carcinoma (HP:0006519)1.99565899
105Recurrent pneumonia (HP:0006532)1.99206374
106Aplasia/Hypoplasia of the tibia (HP:0005772)1.97325343
107Stomach cancer (HP:0012126)1.97179328
108Focal seizures (HP:0007359)1.96057072
109Male pseudohermaphroditism (HP:0000037)1.95654168
110Chorioretinal atrophy (HP:0000533)1.94764558
111Preaxial foot polydactyly (HP:0001841)1.94393116
112Preaxial hand polydactyly (HP:0001177)1.93773319
113Thyroiditis (HP:0100646)1.93307345
114Keratoconjunctivitis (HP:0001096)1.93279151
115Vasculitis (HP:0002633)1.93162129
116Short foot (HP:0001773)1.92874253
117Intestinal atresia (HP:0011100)1.92276116
118Hypoplastic ischia (HP:0003175)1.91452467
119Dynein arm defect of respiratory motile cilia (HP:0012255)1.91126855
120Absent/shortened dynein arms (HP:0200106)1.91126855
121Acute necrotizing encephalopathy (HP:0006965)1.89940958
122Pendular nystagmus (HP:0012043)1.89535932
123Aplasia/Hypoplasia of the uvula (HP:0010293)1.89274740
124Medulloblastoma (HP:0002885)1.88942287
125Drooling (HP:0002307)1.88222084
126Hypoplastic labia majora (HP:0000059)1.87873769
127Epileptic encephalopathy (HP:0200134)1.87865556
128Centrally nucleated skeletal muscle fibers (HP:0003687)1.87446144
129Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87405811
130Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87322830
131Dialeptic seizures (HP:0011146)1.86945839
132Birth length less than 3rd percentile (HP:0003561)1.86799978
133Patchy hypopigmentation of hair (HP:0011365)1.86499594
134Granulocytopenia (HP:0001913)1.86335016
135Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85925514
136Type 2 muscle fiber atrophy (HP:0003554)1.85673572
137Oligodactyly (hands) (HP:0001180)1.85596684
138Abnormality of T cell physiology (HP:0011840)1.84924537
139Abnormality of the ischium (HP:0003174)1.84530234
140Heterochromia iridis (HP:0001100)1.83882102
141Pulmonary infiltrates (HP:0002113)1.82515015
142Encephalitis (HP:0002383)1.81476429
143Abnormality of the renal collecting system (HP:0004742)1.81228984
144Astigmatism (HP:0000483)1.80862001
145Thyroid-stimulating hormone excess (HP:0002925)1.79722208
146Chromsome breakage (HP:0040012)1.79243663
147Optic nerve hypoplasia (HP:0000609)1.79231945
148Congenital, generalized hypertrichosis (HP:0004540)1.78783768
149Dandy-Walker malformation (HP:0001305)1.78605469
150Postaxial hand polydactyly (HP:0001162)1.78601644
151Abnormal ciliary motility (HP:0012262)1.77179800
152Hemiparesis (HP:0001269)1.76850933
153Abnormal mitochondria in muscle tissue (HP:0008316)1.76784038
154Cupped ear (HP:0000378)1.76771314
155Reduced antithrombin III activity (HP:0001976)1.75495365
156Mitochondrial inheritance (HP:0001427)1.75444884
157Abnormality of the labia minora (HP:0012880)1.75404077
158Poor suck (HP:0002033)1.74775356
159Bone marrow hypocellularity (HP:0005528)1.74746779
160Abnormality of the labia majora (HP:0012881)1.74627390
161Central scotoma (HP:0000603)1.74127361
162Highly arched eyebrow (HP:0002553)1.74059623
163Agammaglobulinemia (HP:0004432)1.71317491
164Nephroblastoma (Wilms tumor) (HP:0002667)1.71113163
165Porencephaly (HP:0002132)1.69983405
166Optic disc pallor (HP:0000543)1.69804585
167Generalized hypopigmentation of hair (HP:0011358)1.69737979
168Neoplasm of the tracheobronchial system (HP:0100552)1.69734799
169Neonatal hypoglycemia (HP:0001998)1.69517532
170IgM deficiency (HP:0002850)1.69467336
171Abnormal lung lobation (HP:0002101)1.69079822
172Progressive macrocephaly (HP:0004481)1.68559252
173Aplasia/Hypoplasia of the lens (HP:0008063)1.67620976
174Myelodysplasia (HP:0002863)1.65673583
175Muscle fiber atrophy (HP:0100295)1.65264639
176Eczematoid dermatitis (HP:0000976)1.64753334
177Hemoptysis (HP:0002105)1.64718289
178Protruding tongue (HP:0010808)1.64389139
179Mediastinal lymphadenopathy (HP:0100721)1.62278513

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD45.69986822
2MAP2K74.28495607
3MAP3K124.19427125
4MAP3K43.32191385
5ACVR1B3.31134207
6BMPR1B3.25167660
7MKNK22.98429780
8CASK2.70059959
9MAP3K142.54373078
10MKNK12.36511151
11WNK32.30160941
12MAP3K132.10640859
13TXK2.09820770
14IRAK42.09383342
15TSSK61.99923065
16TAOK31.99752635
17GRK11.99525390
18INSRR1.96755811
19PRPF4B1.90004126
20NEK91.87588380
21MAP4K21.77676682
22STK161.75281073
23PBK1.60731153
24MAP2K41.60370083
25TEC1.60296637
26MYLK1.56439603
27CDK81.55824720
28CDK31.52818704
29CDK91.52138419
30MAP3K61.47862037
31ZAK1.47225979
32NME21.38580389
33PINK11.35045041
34CCNB11.33883086
35STK391.23773565
36EIF2AK11.21372152
37AKT31.16351700
38TIE11.15513417
39NTRK31.15135769
40JAK31.13685435
41BUB11.13552461
42MARK11.12514095
43GRK71.11648948
44WNK41.11068309
45CDK191.10379902
46TGFBR11.09369533
47IKBKE1.06489412
48EPHA41.05257343
49BCR1.04774773
50VRK11.04679951
51FRK1.03692966
52TLK11.03210113
53ADRBK21.03194376
54PNCK0.96408488
55PAK30.94858209
56PLK20.93824771
57BTK0.93259048
58PLK40.92848334
59MAPK130.92816796
60DAPK10.90400405
61FGFR20.88801569
62PIK3CA0.88276194
63LATS10.87163911
64YES10.86437562
65SIK30.85350022
66NUAK10.84230841
67DAPK20.83686594
68EPHA30.83204059
69PRKCE0.82916613
70EIF2AK20.80062714
71SGK20.78869326
72PTK2B0.78644737
73KIT0.77354845
74CLK10.76964229
75PRKCG0.76083407
76IKBKB0.75407747
77STK30.73633319
78PIK3CG0.73612179
79TBK10.69779497
80PLK30.66373095
81CSNK1G30.65618235
82TRIM280.65034490
83CAMK1G0.64189276
84ATR0.63324325
85NLK0.61112133
86BMPR20.60404782
87TNIK0.59845247
88FER0.59261682
89SRPK10.58848138
90TAOK20.58553689
91TRPM70.58475638
92CSNK1G20.57914359
93OBSCN0.57555721
94PKN10.57242700
95ERBB30.56505715
96CSF1R0.55832254
97PRKAA20.55614292
98FLT30.55452297
99PLK10.55443402
100ITK0.54429119
101ADRBK10.53367577
102CAMK2A0.53313764
103BRSK20.52190306
104MAP4K10.51995986
105LYN0.49700463
106NEK60.49212417
107MST40.49043088
108NTRK20.48312859
109CAMK1D0.47133499
110CSNK1A1L0.46897608
111CHUK0.45722233
112SYK0.45494002
113DYRK20.44847706
114IRAK10.44537622
115PRKAA10.44489550
116TYK20.44177900
117ERBB20.44113420
118LCK0.43935012
119SGK2230.43759624
120SGK4940.43759624
121EIF2AK30.43611453
122CAMK10.42939235
123STK110.42920026
124CAMKK20.42743933
125MAPKAPK50.41751382
126CDC70.41155254
127BLK0.40947502
128MELK0.40735288
129CSNK1D0.40014020
130DYRK1A0.39920107
131MAP3K70.39101562
132FES0.38613937
133WEE10.37910218
134RIPK40.37892953
135SIK20.37871820
136MAP3K110.37177788
137MUSK0.36886502
138STK38L0.36754935
139STK380.36083660
140PRKACA0.35928859
141CSNK1G10.35774465
142TNK20.34967836
143CSK0.34600385
144RPS6KB10.33919703
145CDK140.33363766
146CHEK20.33297319
147ATM0.33215177
148RPS6KA50.32895118
149MAP3K50.31597296
150CSNK1A10.31236698
151OXSR10.30976262
152CAMK40.30897216
153CDK180.30365349
154PRKG10.29410197
155MAPKAPK20.29256796
156MAPK40.28751919
157CSNK2A10.28063675

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.43009550
2DNA replication_Homo sapiens_hsa030303.03059684
3Phototransduction_Homo sapiens_hsa047442.68327614
4Butanoate metabolism_Homo sapiens_hsa006502.53039799
5Base excision repair_Homo sapiens_hsa034102.48931082
6Basal transcription factors_Homo sapiens_hsa030222.39301736
7Nitrogen metabolism_Homo sapiens_hsa009102.36713053
8Allograft rejection_Homo sapiens_hsa053302.32299172
9Protein export_Homo sapiens_hsa030602.30370480
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.27876389
11Linoleic acid metabolism_Homo sapiens_hsa005912.25277242
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.17237682
13Homologous recombination_Homo sapiens_hsa034402.17188162
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16410926
15ABC transporters_Homo sapiens_hsa020102.09327313
16Taste transduction_Homo sapiens_hsa047422.08633344
17SNARE interactions in vesicular transport_Homo sapiens_hsa041302.06630005
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04040179
19Selenocompound metabolism_Homo sapiens_hsa004502.02564775
20Tryptophan metabolism_Homo sapiens_hsa003802.01862738
21Proteasome_Homo sapiens_hsa030502.00248089
22Primary immunodeficiency_Homo sapiens_hsa053401.90027496
23Mismatch repair_Homo sapiens_hsa034301.83262757
24RNA polymerase_Homo sapiens_hsa030201.81664745
25Non-homologous end-joining_Homo sapiens_hsa034501.79656250
26Type I diabetes mellitus_Homo sapiens_hsa049401.75020256
27Olfactory transduction_Homo sapiens_hsa047401.70867668
28Graft-versus-host disease_Homo sapiens_hsa053321.70458480
29Ether lipid metabolism_Homo sapiens_hsa005651.69631149
30Legionellosis_Homo sapiens_hsa051341.68068703
31Rheumatoid arthritis_Homo sapiens_hsa053231.67443420
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63608119
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63340524
34Measles_Homo sapiens_hsa051621.62103184
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.60729775
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.59236047
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.58580480
38Autoimmune thyroid disease_Homo sapiens_hsa053201.56687705
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.54429178
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.52768332
41Glutamatergic synapse_Homo sapiens_hsa047241.51727551
42Cell cycle_Homo sapiens_hsa041101.48737057
43Nucleotide excision repair_Homo sapiens_hsa034201.47913222
44Propanoate metabolism_Homo sapiens_hsa006401.45852924
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.41864384
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39735734
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38726276
48Herpes simplex infection_Homo sapiens_hsa051681.36223364
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35169068
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33678285
51Nicotine addiction_Homo sapiens_hsa050331.26203628
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24903860
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21639727
54Epstein-Barr virus infection_Homo sapiens_hsa051691.21303445
55Fanconi anemia pathway_Homo sapiens_hsa034601.21045043
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20398198
57Spliceosome_Homo sapiens_hsa030401.19863364
58Calcium signaling pathway_Homo sapiens_hsa040201.19591052
59RNA degradation_Homo sapiens_hsa030181.18790881
60Insulin secretion_Homo sapiens_hsa049111.17557261
61Salivary secretion_Homo sapiens_hsa049701.17094927
62Retinol metabolism_Homo sapiens_hsa008301.13519491
63Chemical carcinogenesis_Homo sapiens_hsa052041.09033692
64Morphine addiction_Homo sapiens_hsa050321.08376732
65Collecting duct acid secretion_Homo sapiens_hsa049661.08328564
66Ovarian steroidogenesis_Homo sapiens_hsa049131.07368255
67Glycerolipid metabolism_Homo sapiens_hsa005611.06561397
68Histidine metabolism_Homo sapiens_hsa003401.05816538
69Dorso-ventral axis formation_Homo sapiens_hsa043201.04691900
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04498645
71Pyrimidine metabolism_Homo sapiens_hsa002401.04446524
72Leishmaniasis_Homo sapiens_hsa051401.04276660
73Synaptic vesicle cycle_Homo sapiens_hsa047211.04100449
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03073596
75Oxidative phosphorylation_Homo sapiens_hsa001901.02947495
76Phagosome_Homo sapiens_hsa041451.02059970
77NF-kappa B signaling pathway_Homo sapiens_hsa040641.01838336
78Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01454471
79Purine metabolism_Homo sapiens_hsa002300.98589681
80Lysine degradation_Homo sapiens_hsa003100.96981227
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96183389
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94585169
83Vibrio cholerae infection_Homo sapiens_hsa051100.93386438
84Antigen processing and presentation_Homo sapiens_hsa046120.93084527
85Hepatitis B_Homo sapiens_hsa051610.91321066
86Parkinsons disease_Homo sapiens_hsa050120.91196595
87Influenza A_Homo sapiens_hsa051640.91041703
88Malaria_Homo sapiens_hsa051440.90688067
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88176613
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.87020212
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84772680
92Cholinergic synapse_Homo sapiens_hsa047250.83952875
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82503241
94Tuberculosis_Homo sapiens_hsa051520.80691987
95Shigellosis_Homo sapiens_hsa051310.79954514
96beta-Alanine metabolism_Homo sapiens_hsa004100.78189579
97cAMP signaling pathway_Homo sapiens_hsa040240.77953098
98Peroxisome_Homo sapiens_hsa041460.77658556
99Arachidonic acid metabolism_Homo sapiens_hsa005900.77403712
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75300537
101Pertussis_Homo sapiens_hsa051330.75056088
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74922171
103Circadian rhythm_Homo sapiens_hsa047100.74558011
104Chemokine signaling pathway_Homo sapiens_hsa040620.73904112
105GABAergic synapse_Homo sapiens_hsa047270.72027853
106TNF signaling pathway_Homo sapiens_hsa046680.70308254
107Gastric acid secretion_Homo sapiens_hsa049710.69337195
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.69148853
109Serotonergic synapse_Homo sapiens_hsa047260.68991164
110p53 signaling pathway_Homo sapiens_hsa041150.67672037
111Oxytocin signaling pathway_Homo sapiens_hsa049210.66274842
112Circadian entrainment_Homo sapiens_hsa047130.65297158
113Hematopoietic cell lineage_Homo sapiens_hsa046400.64766715
114Huntingtons disease_Homo sapiens_hsa050160.64579685
115Renin secretion_Homo sapiens_hsa049240.63566525
116Fatty acid biosynthesis_Homo sapiens_hsa000610.63302132
117Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62148993
118One carbon pool by folate_Homo sapiens_hsa006700.61940652
119Oocyte meiosis_Homo sapiens_hsa041140.60024660
120T cell receptor signaling pathway_Homo sapiens_hsa046600.59881333
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58756935
122Pancreatic cancer_Homo sapiens_hsa052120.58245220
123Toxoplasmosis_Homo sapiens_hsa051450.56092225
124Dopaminergic synapse_Homo sapiens_hsa047280.55977604
125Viral carcinogenesis_Homo sapiens_hsa052030.55545658
126Hedgehog signaling pathway_Homo sapiens_hsa043400.54289114
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52687383
128Cocaine addiction_Homo sapiens_hsa050300.52470911
129Type II diabetes mellitus_Homo sapiens_hsa049300.52160182
130Osteoclast differentiation_Homo sapiens_hsa043800.50934429
131Amphetamine addiction_Homo sapiens_hsa050310.50169760
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49218554
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48742915
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48242845
135Regulation of autophagy_Homo sapiens_hsa041400.48156871
136Alzheimers disease_Homo sapiens_hsa050100.47732956
137Hepatitis C_Homo sapiens_hsa051600.47372537
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46587016
139TGF-beta signaling pathway_Homo sapiens_hsa043500.45513250
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44697660
141Salmonella infection_Homo sapiens_hsa051320.44421022
142Basal cell carcinoma_Homo sapiens_hsa052170.43506254
143HTLV-I infection_Homo sapiens_hsa051660.42612714
144Systemic lupus erythematosus_Homo sapiens_hsa053220.41306252
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40179593
146Long-term depression_Homo sapiens_hsa047300.40095587
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38983326
148Asthma_Homo sapiens_hsa053100.38374602
149Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38264585
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.38220472
151B cell receptor signaling pathway_Homo sapiens_hsa046620.38184846
152Pancreatic secretion_Homo sapiens_hsa049720.37995422
153cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37252181
154Alcoholism_Homo sapiens_hsa050340.36880451
155Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35620473
156Sphingolipid metabolism_Homo sapiens_hsa006000.35484856
157N-Glycan biosynthesis_Homo sapiens_hsa005100.35128712
158Apoptosis_Homo sapiens_hsa042100.34896550
159Fatty acid degradation_Homo sapiens_hsa000710.34556176
160Hippo signaling pathway_Homo sapiens_hsa043900.34214783
161Vitamin digestion and absorption_Homo sapiens_hsa049770.33805697
162Fat digestion and absorption_Homo sapiens_hsa049750.33205493
163Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31635821
164Ribosome_Homo sapiens_hsa030100.31635536
165Metabolic pathways_Homo sapiens_hsa011000.30925668
166Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30438320
167Axon guidance_Homo sapiens_hsa043600.29841777
168Melanoma_Homo sapiens_hsa052180.28561756
169Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27846720
170Ras signaling pathway_Homo sapiens_hsa040140.26801442
171Cysteine and methionine metabolism_Homo sapiens_hsa002700.26691621

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