ASB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tryptophan catabolic process (GO:0006569)5.03896574
2indole-containing compound catabolic process (GO:0042436)5.03896574
3indolalkylamine catabolic process (GO:0046218)5.03896574
4kynurenine metabolic process (GO:0070189)5.00832907
5regulation of memory T cell differentiation (GO:0043380)5.00688370
6detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.67752787
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.52132058
8sex differentiation (GO:0007548)4.48322578
9regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.40898879
10indolalkylamine metabolic process (GO:0006586)4.39703454
11protein K11-linked deubiquitination (GO:0035871)4.38818411
12tryptophan metabolic process (GO:0006568)4.26377328
13benzene-containing compound metabolic process (GO:0042537)4.17304763
14regulation of establishment of cell polarity (GO:2000114)4.11955792
15uterus development (GO:0060065)4.04751656
16negative regulation of multicellular organism growth (GO:0040015)4.04540025
17auditory receptor cell stereocilium organization (GO:0060088)4.03757550
18nephron tubule morphogenesis (GO:0072078)3.98608336
19nephron epithelium morphogenesis (GO:0072088)3.98608336
20paraxial mesoderm development (GO:0048339)3.96312395
21androgen biosynthetic process (GO:0006702)3.95524295
22regulation of sarcomere organization (GO:0060297)3.87951334
23endocardial cushion morphogenesis (GO:0003203)3.87399707
24cell proliferation involved in metanephros development (GO:0072203)3.86127809
25lymph vessel development (GO:0001945)3.82462299
26neuronal action potential propagation (GO:0019227)3.82216988
27regulation of skeletal muscle contraction (GO:0014819)3.78485506
28negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.75147641
29cellular ketone body metabolic process (GO:0046950)3.65638211
30estrogen biosynthetic process (GO:0006703)3.63471189
31cytoplasmic mRNA processing body assembly (GO:0033962)3.61098122
32neural tube formation (GO:0001841)3.58850357
33cell proliferation involved in kidney development (GO:0072111)3.57354966
34regulation of cardioblast differentiation (GO:0051890)3.54513586
35body morphogenesis (GO:0010171)3.53156200
36mesenchyme morphogenesis (GO:0072132)3.49195294
37ketone body metabolic process (GO:1902224)3.49096141
38atrial septum morphogenesis (GO:0060413)3.48167858
39regulation of establishment or maintenance of cell polarity (GO:0032878)3.45212266
40dopaminergic neuron differentiation (GO:0071542)3.43341908
41regulation of non-canonical Wnt signaling pathway (GO:2000050)3.43144080
42reflex (GO:0060004)3.42898862
43genetic imprinting (GO:0071514)3.42150715
44regulation of MHC class I biosynthetic process (GO:0045343)3.40294431
45mesenchymal cell proliferation (GO:0010463)3.39694064
46cholesterol catabolic process (GO:0006707)3.38424673
47sterol catabolic process (GO:0016127)3.38424673
48detection of light stimulus involved in sensory perception (GO:0050962)3.35359597
49detection of light stimulus involved in visual perception (GO:0050908)3.35359597
50cellular biogenic amine catabolic process (GO:0042402)3.34286961
51amine catabolic process (GO:0009310)3.34286961
52negative regulation of striated muscle cell apoptotic process (GO:0010664)3.34200161
53inner ear receptor stereocilium organization (GO:0060122)3.33244204
54signal peptide processing (GO:0006465)3.25817417
55cardiac myofibril assembly (GO:0055003)3.23335935
56L-fucose catabolic process (GO:0042355)3.22989502
57fucose catabolic process (GO:0019317)3.22989502
58L-fucose metabolic process (GO:0042354)3.22989502
59photoreceptor cell maintenance (GO:0045494)3.22762360
60righting reflex (GO:0060013)3.21400281
61negative regulation of axon guidance (GO:1902668)3.20911822
62behavioral response to nicotine (GO:0035095)3.20204316
63L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.19318779
64neuron projection extension involved in neuron projection guidance (GO:1902284)3.18506650
65axon extension involved in axon guidance (GO:0048846)3.18506650
66ADP metabolic process (GO:0046031)3.17836318
67synaptic transmission, cholinergic (GO:0007271)3.17194457
68negative regulation of axon extension involved in axon guidance (GO:0048843)3.16716758
69embryonic foregut morphogenesis (GO:0048617)3.14249044
70indole-containing compound metabolic process (GO:0042430)3.12736961
71NAD biosynthetic process (GO:0009435)3.09171829
72aromatic amino acid family catabolic process (GO:0009074)3.09111527
73dopamine transport (GO:0015872)3.09044113
74regulation of glucokinase activity (GO:0033131)3.08194551
75regulation of hexokinase activity (GO:1903299)3.08194551
76regulation of action potential (GO:0098900)3.07404932
77protein K63-linked deubiquitination (GO:0070536)3.05091122
78bile acid biosynthetic process (GO:0006699)3.04491638
79regulation of cardioblast proliferation (GO:0003264)3.01393834
80regulation of secondary heart field cardioblast proliferation (GO:0003266)3.01393834
81cilium or flagellum-dependent cell motility (GO:0001539)3.01297283
82renal tubule morphogenesis (GO:0061333)3.00993311
83sulfation (GO:0051923)2.98708381
84organ formation (GO:0048645)2.94980857
85detection of mechanical stimulus involved in sensory perception (GO:0050974)2.93701151
86glomerular filtration (GO:0003094)2.89537220
87negative regulation of calcium ion transport into cytosol (GO:0010523)2.88097293
88lateral sprouting from an epithelium (GO:0060601)2.87812783
89negative regulation of mast cell activation (GO:0033004)2.86784708
90regulation of heart morphogenesis (GO:2000826)2.86532014
91neural crest cell development (GO:0014032)2.84174921
92muscle filament sliding (GO:0030049)2.83975299
93actin-myosin filament sliding (GO:0033275)2.83975299
94axonal fasciculation (GO:0007413)2.82486906
95atrial cardiac muscle cell action potential (GO:0086014)2.82294188
96mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.81883676
97endothelium development (GO:0003158)2.80564874
98cerebral cortex radially oriented cell migration (GO:0021799)2.80279176
99regulation of mesoderm development (GO:2000380)2.79449486
100heart trabecula formation (GO:0060347)2.79048530
101negative regulation of stem cell proliferation (GO:2000647)2.78349218
102negative regulation of cytosolic calcium ion concentration (GO:0051481)2.76483902
103cell migration involved in heart development (GO:0060973)2.76173026
104embryonic heart tube development (GO:0035050)2.75449124
105amino acid salvage (GO:0043102)2.74949488
106L-methionine salvage (GO:0071267)2.74949488
107L-methionine biosynthetic process (GO:0071265)2.74949488
108endocardial cushion development (GO:0003197)2.74234883
109cardiac right ventricle morphogenesis (GO:0003215)2.73867789
110regulation of transforming growth factor beta2 production (GO:0032909)2.72988878
111cellular response to sterol (GO:0036315)2.72871118
112negative regulation of embryonic development (GO:0045992)2.71386586
113behavioral response to ethanol (GO:0048149)2.71378507
114establishment of protein localization to Golgi (GO:0072600)2.71220672
115aromatic amino acid family metabolic process (GO:0009072)2.70983138
116lipid particle organization (GO:0034389)2.70826872
117regulation of endothelial cell differentiation (GO:0045601)2.70061517
118tachykinin receptor signaling pathway (GO:0007217)2.69635306
119proline transport (GO:0015824)2.69496457
120ATP synthesis coupled proton transport (GO:0015986)2.68234596
121energy coupled proton transport, down electrochemical gradient (GO:0015985)2.68234596
122peptidyl-arginine omega-N-methylation (GO:0035247)2.67762065
123notochord development (GO:0030903)2.67425501
124outflow tract septum morphogenesis (GO:0003148)2.66674330
125G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65220614
126exocrine pancreas development (GO:0031017)2.65170604
127peptidyl-arginine methylation (GO:0018216)2.64732807
128peptidyl-arginine N-methylation (GO:0035246)2.64732807
129DNA strand renaturation (GO:0000733)2.64067381
130midgut development (GO:0007494)2.63842786
131regulation of relaxation of muscle (GO:1901077)2.62949329
132mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.62297794
133artery development (GO:0060840)2.61733363
134interkinetic nuclear migration (GO:0022027)2.61530304
135monoubiquitinated protein deubiquitination (GO:0035520)2.61528002
136proximal/distal pattern formation (GO:0009954)2.61483639
137artery smooth muscle contraction (GO:0014824)2.61056495
138positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.59535730
139positive regulation of triglyceride biosynthetic process (GO:0010867)2.59313406
140regulation of organ formation (GO:0003156)2.57796121
141neuronal action potential (GO:0019228)2.57503150
142embryonic forelimb morphogenesis (GO:0035115)2.56899091
143somite development (GO:0061053)2.56862595
144thalamus development (GO:0021794)2.56772327
145dopamine biosynthetic process (GO:0042416)2.56420837
146regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.55398306
147thyroid hormone metabolic process (GO:0042403)2.55179950
148adenosine metabolic process (GO:0046085)2.54113908
149heart contraction (GO:0060047)2.54068552
150heart process (GO:0003015)2.54068552
151regulation of hippo signaling (GO:0035330)2.53937001
152regulation of glucocorticoid secretion (GO:2000849)2.53813417
153head development (GO:0060322)2.53608716
154positive regulation of smoothened signaling pathway (GO:0045880)2.53568697
155mesenchymal cell development (GO:0014031)2.53118343
156aspartate family amino acid catabolic process (GO:0009068)2.52691281
157cardiac chamber morphogenesis (GO:0003206)2.52077066
158establishment of planar polarity (GO:0001736)2.50666113
159establishment of tissue polarity (GO:0007164)2.50666113
160actin-mediated cell contraction (GO:0070252)2.50587109
161positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.50149907
162methionine biosynthetic process (GO:0009086)2.49970373
163branching involved in ureteric bud morphogenesis (GO:0001658)2.49570164
164hindbrain development (GO:0030902)2.49427953
165embryonic skeletal joint morphogenesis (GO:0060272)2.49419979
166primary amino compound metabolic process (GO:1901160)2.49418683
167sarcoplasmic reticulum calcium ion transport (GO:0070296)2.49415755
168positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.48870306
169kinetochore organization (GO:0051383)2.48656351
170glucocorticoid biosynthetic process (GO:0006704)2.48567245
171regulation of transmission of nerve impulse (GO:0051969)2.48455237
172hormone biosynthetic process (GO:0042446)2.48102776
173central nervous system neuron axonogenesis (GO:0021955)2.47900374
174skeletal muscle adaptation (GO:0043501)2.46470704
175genitalia morphogenesis (GO:0035112)2.46427046
176retinal ganglion cell axon guidance (GO:0031290)2.46188775
177positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.44913712
178regulation of smooth muscle cell differentiation (GO:0051150)2.44733918
179acrosome assembly (GO:0001675)2.44410298
180histone arginine methylation (GO:0034969)2.44358962
181phospholipid translocation (GO:0045332)2.44165054
182lipid translocation (GO:0034204)2.44165054
183cardiac muscle tissue morphogenesis (GO:0055008)2.43656460
184trabecula formation (GO:0060343)2.43097844
185left/right axis specification (GO:0070986)2.42647816
186myofibril assembly (GO:0030239)2.41780232
187startle response (GO:0001964)2.41753753
188regulation of collateral sprouting (GO:0048670)2.41530051
189regulation of axon guidance (GO:1902667)2.41328897
190cellular response to toxic substance (GO:0097237)2.40209866
191serotonin metabolic process (GO:0042428)2.39779503
192negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.38753942
193membrane depolarization during action potential (GO:0086010)2.38605690
194mesenchyme development (GO:0060485)2.38592298
195short-term memory (GO:0007614)2.38334277
196centrosome duplication (GO:0051298)2.38256887
197embryonic epithelial tube formation (GO:0001838)2.38252834
198renal filtration (GO:0097205)2.38081776

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.44890905
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.01001668
3GBX2_23144817_ChIP-Seq_PC3_Human3.64662442
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.46436007
5IGF1R_20145208_ChIP-Seq_DFB_Human3.40808894
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.09370211
7BMI1_23680149_ChIP-Seq_NPCS_Mouse2.83714990
8CBX2_27304074_Chip-Seq_ESCs_Mouse2.62360318
9PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.58175431
10EZH2_22144423_ChIP-Seq_EOC_Human2.44586730
11WT1_19549856_ChIP-ChIP_CCG9911_Human2.39304607
12POU5F1_16153702_ChIP-ChIP_HESCs_Human2.37162209
13* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.31893183
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.30564983
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.25491677
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.25487375
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20216093
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.19586079
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.17188591
20DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.15694746
21RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.14155054
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11228688
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.08365500
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02545564
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.99771607
26ZNF274_21170338_ChIP-Seq_K562_Hela1.99573222
27RNF2_27304074_Chip-Seq_NSC_Mouse1.96515566
28BCAT_22108803_ChIP-Seq_LS180_Human1.92761885
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91644791
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90793975
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89457181
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89348148
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88093613
34FUS_26573619_Chip-Seq_HEK293_Human1.85559027
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85280652
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84453442
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.84235656
38E2F7_22180533_ChIP-Seq_HELA_Human1.82820138
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82245183
40TAF15_26573619_Chip-Seq_HEK293_Human1.81257069
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77196507
42* STAT3_23295773_ChIP-Seq_U87_Human1.73463058
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72191944
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72191944
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70207699
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69199293
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68215353
48ISL1_27105846_Chip-Seq_CPCs_Mouse1.66782795
49* TCF4_23295773_ChIP-Seq_U87_Human1.64542891
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63257673
51CBP_20019798_ChIP-Seq_JUKART_Human1.63257673
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.62371718
53AR_25329375_ChIP-Seq_VCAP_Human1.61917649
54SOX2_16153702_ChIP-ChIP_HESCs_Human1.60880062
55P300_19829295_ChIP-Seq_ESCs_Human1.60839145
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.60446270
57EWS_26573619_Chip-Seq_HEK293_Human1.56772949
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56314520
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52429398
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51282399
61JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46490175
62VDR_22108803_ChIP-Seq_LS180_Human1.43312639
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.42004085
64SMAD4_21741376_ChIP-Seq_EPCs_Human1.40184634
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39850408
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.39628161
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.38654574
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.38192216
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.37939829
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.37896612
71HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37510244
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37264839
73TCF4_22108803_ChIP-Seq_LS180_Human1.37063088
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36284852
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.36276276
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.36159909
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36024841
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.34909922
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33924761
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32367844
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32367844
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31634032
83AR_21572438_ChIP-Seq_LNCaP_Human1.31420155
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30368681
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29746656
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28775331
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.28481115
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.28058602
89* CDX2_22108803_ChIP-Seq_LS180_Human1.26696107
90OCT4_21477851_ChIP-Seq_ESCs_Mouse1.25312894
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24993746
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24233675
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23162697
94TP53_22573176_ChIP-Seq_HFKS_Human1.22983419
95NANOG_19829295_ChIP-Seq_ESCs_Human1.21570116
96SOX2_19829295_ChIP-Seq_ESCs_Human1.21570116
97RING1B_27294783_Chip-Seq_NPCs_Mouse1.21349464
98DROSHA_22980978_ChIP-Seq_HELA_Human1.21132659
99* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19617644
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.18193085
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16979804
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16574092
103MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16515836
104P53_22387025_ChIP-Seq_ESCs_Mouse1.16059113
105EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15173695
106RING1B_27294783_Chip-Seq_ESCs_Mouse1.15169445
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.14998321
108FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14215115
109FOXA1_25329375_ChIP-Seq_VCAP_Human1.14215115
110GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13427763
111FOXM1_23109430_ChIP-Seq_U2OS_Human1.13011567
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12172120
113HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.12020212
114SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11937978
115TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11654143
116SOX9_26525672_Chip-Seq_HEART_Mouse1.11363174
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11326584
118SOX2_21211035_ChIP-Seq_LN229_Gbm1.10827598
119FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10571343
120NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10528221
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10313594
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.10248773
123KDM2B_26808549_Chip-Seq_REH_Human1.09407403
124STAT3_18555785_Chip-Seq_ESCs_Mouse1.09253183
125SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09024342
126NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08934129
127GF1B_26923725_Chip-Seq_HPCs_Mouse1.08737167
128RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07907733
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07425865
130ARNT_22903824_ChIP-Seq_MCF-7_Human1.05834884
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05443920
132CJUN_26792858_Chip-Seq_BT549_Human1.05137049
133RUNX2_22187159_ChIP-Seq_PCA_Human1.04452614
134FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03575464
135TAL1_26923725_Chip-Seq_HPCs_Mouse1.03270395
136TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03264470
137REST_21632747_ChIP-Seq_MESCs_Mouse1.02671080
138SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02444890
139CMYC_18555785_Chip-Seq_ESCs_Mouse1.02399975
140NANOG_16153702_ChIP-ChIP_HESCs_Human1.02050071
141NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01462308
142NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01462308
143* SMAD4_21799915_ChIP-Seq_A2780_Human1.01412653
144P300_18555785_Chip-Seq_ESCs_Mouse1.01323769
145TBL1_22424771_ChIP-Seq_293T_Human1.01212801
146* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00716488
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00515700
148KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99397831
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99071960
150KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97688304
151SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96830160
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96728702
153DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96602807
154TP53_20018659_ChIP-ChIP_R1E_Mouse0.96440373
155PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96280722
156E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95421966
157MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94418815
158* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93378941
159* ER_23166858_ChIP-Seq_MCF-7_Human0.92903087
160SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.92835589
161IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92542677
162* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91743005
163* SOX17_20123909_ChIP-Seq_XEN_Mouse0.91446644
164TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88775862
165TTF2_22483619_ChIP-Seq_HELA_Human0.88241814
166MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88134588
167TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87790968

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting7.80125524
2MP0003123_paternal_imprinting5.47118048
3MP0003121_genomic_imprinting5.37495232
4MP0003646_muscle_fatigue4.13626394
5MP0003195_calcinosis2.81815446
6MP0003787_abnormal_imprinting2.73956964
7MP0002837_dystrophic_cardiac_calcinosis2.54768915
8MP0002938_white_spotting2.53918813
9MP0003011_delayed_dark_adaptation2.53736698
10MP0002736_abnormal_nociception_after2.46610458
11MP0005645_abnormal_hypothalamus_physiol2.46286147
12MP0010368_abnormal_lymphatic_system2.39577326
13MP0003252_abnormal_bile_duct2.34787404
14MP0005551_abnormal_eye_electrophysiolog2.33476648
15MP0000372_irregular_coat_pigmentation2.30678616
16MP0004272_abnormal_basement_membrane2.27193710
17MP0003385_abnormal_body_wall2.21227071
18MP0009697_abnormal_copulation2.19832952
19MP0003950_abnormal_plasma_membrane2.19579034
20MP0001501_abnormal_sleep_pattern2.17905661
21MP0005253_abnormal_eye_physiology2.17140107
22MP0000537_abnormal_urethra_morphology2.08334472
23MP0003942_abnormal_urinary_system2.05601837
24MP0000566_synostosis2.05118650
25MP0001879_abnormal_lymphatic_vessel2.05072494
26MP0009046_muscle_twitch2.05052806
27MP0009053_abnormal_anal_canal1.96922514
28MP0003315_abnormal_perineum_morphology1.89059421
29MP0005646_abnormal_pituitary_gland1.85971252
30MP0000049_abnormal_middle_ear1.80357155
31MP0009745_abnormal_behavioral_response1.80208402
32MP0002138_abnormal_hepatobiliary_system1.79716420
33MP0010030_abnormal_orbit_morphology1.78576294
34MP0009250_abnormal_appendicular_skeleto1.72404683
35MP0006072_abnormal_retinal_apoptosis1.69225794
36MP0004036_abnormal_muscle_relaxation1.66506212
37MP0006276_abnormal_autonomic_nervous1.65030340
38MP0004043_abnormal_pH_regulation1.64260678
39MP0001984_abnormal_olfaction1.63275135
40MP0003937_abnormal_limbs/digits/tail_de1.62330954
41MP0003136_yellow_coat_color1.61203277
42MP0002249_abnormal_larynx_morphology1.53159485
43MP0000427_abnormal_hair_cycle1.52842137
44MP0002282_abnormal_trachea_morphology1.49542115
45MP0001486_abnormal_startle_reflex1.47990208
46MP0002163_abnormal_gland_morphology1.40684058
47MP0005503_abnormal_tendon_morphology1.39110984
48MP0000013_abnormal_adipose_tissue1.37435757
49MP0003567_abnormal_fetal_cardiomyocyte1.36565497
50MP0004142_abnormal_muscle_tone1.34508203
51MP0001485_abnormal_pinna_reflex1.33405473
52MP0001986_abnormal_taste_sensitivity1.32863849
53MP0008875_abnormal_xenobiotic_pharmacok1.32434662
54MP0002876_abnormal_thyroid_physiology1.31730224
55MP0004484_altered_response_of1.30700262
56MP0008877_abnormal_DNA_methylation1.28991843
57MP0002106_abnormal_muscle_physiology1.27574633
58MP0003935_abnormal_craniofacial_develop1.26275573
59MP0005084_abnormal_gallbladder_morpholo1.25935012
60MP0002932_abnormal_joint_morphology1.24966129
61MP0005670_abnormal_white_adipose1.23380083
62MP0003137_abnormal_impulse_conducting1.22685884
63MP0002272_abnormal_nervous_system1.21730592
64MP0002234_abnormal_pharynx_morphology1.21166994
65MP0002909_abnormal_adrenal_gland1.21094837
66MP0008872_abnormal_physiological_respon1.19725287
67MP0000631_abnormal_neuroendocrine_gland1.17960093
68MP0000371_diluted_coat_color1.17413613
69MP0002127_abnormal_cardiovascular_syste1.16741895
70MP0002064_seizures1.15733372
71MP0004130_abnormal_muscle_cell1.15228378
72MP0002751_abnormal_autonomic_nervous1.14721117
73MP0006036_abnormal_mitochondrial_physio1.14415183
74MP0003755_abnormal_palate_morphology1.14007889
75MP0002653_abnormal_ependyma_morphology1.13745283
76MP0000639_abnormal_adrenal_gland1.13637475
77MP0005408_hypopigmentation1.13388236
78MP0005085_abnormal_gallbladder_physiolo1.13038637
79MP0005174_abnormal_tail_pigmentation1.13037889
80MP0002332_abnormal_exercise_endurance1.12557065
81MP0003119_abnormal_digestive_system1.11967534
82MP0005386_behavior/neurological_phenoty1.09812814
83MP0004924_abnormal_behavior1.09812814
84MP0005266_abnormal_metabolism1.08458260
85MP0002177_abnormal_outer_ear1.07337240
86MP0005369_muscle_phenotype1.06588763
87MP0002638_abnormal_pupillary_reflex1.06203453
88MP0004084_abnormal_cardiac_muscle1.05971173
89MP0000230_abnormal_systemic_arterial1.04666879
90MP0005187_abnormal_penis_morphology1.03471278
91MP0002269_muscular_atrophy1.02712447
92MP0002067_abnormal_sensory_capabilities1.02456138
93MP0002116_abnormal_craniofacial_bone1.01602463
94MP0009379_abnormal_foot_pigmentation1.00292033
95MP0000751_myopathy0.99866102
96MP0003943_abnormal_hepatobiliary_system0.98261225
97MP0004145_abnormal_muscle_electrophysio0.98239853
98MP0001293_anophthalmia0.97992135
99MP0005075_abnormal_melanosome_morpholog0.97814207
100MP0006292_abnormal_olfactory_placode0.97462495
101MP0005647_abnormal_sex_gland0.97291865
102MP0005623_abnormal_meninges_morphology0.96952946
103MP0003718_maternal_effect0.96800653
104MP0010386_abnormal_urinary_bladder0.95415488
105MP0001905_abnormal_dopamine_level0.95049383
106MP0000383_abnormal_hair_follicle0.94837029
107MP0000778_abnormal_nervous_system0.93980907
108MP0002233_abnormal_nose_morphology0.93950840
109MP0002572_abnormal_emotion/affect_behav0.93893919
110MP0001286_abnormal_eye_development0.92124677
111MP0004885_abnormal_endolymph0.92027230
112MP0000762_abnormal_tongue_morphology0.91694802
113MP0004233_abnormal_muscle_weight0.91590994
114MP0004215_abnormal_myocardial_fiber0.91309239
115MP0005410_abnormal_fertilization0.90026456
116MP0002102_abnormal_ear_morphology0.89308846
117MP0003045_fibrosis0.88947828
118MP0009384_cardiac_valve_regurgitation0.88863942
119MP0003938_abnormal_ear_development0.88307343
120MP0003115_abnormal_respiratory_system0.87761966
121MP0005167_abnormal_blood-brain_barrier0.87532857
122MP0002733_abnormal_thermal_nociception0.86967857
123MP0000534_abnormal_ureter_morphology0.86896558
124MP0009672_abnormal_birth_weight0.86235580
125MP0002229_neurodegeneration0.85911154
126MP0004197_abnormal_fetal_growth/weight/0.85734686
127MP0002972_abnormal_cardiac_muscle0.85402917
128MP0001968_abnormal_touch/_nociception0.85347631
129MP0002084_abnormal_developmental_patter0.85030436
130MP0002928_abnormal_bile_duct0.84115344
131MP0005310_abnormal_salivary_gland0.83523886
132MP0002109_abnormal_limb_morphology0.83348824
133MP0003890_abnormal_embryonic-extraembry0.82938213
134MP0001970_abnormal_pain_threshold0.81843423
135MP0002557_abnormal_social/conspecific_i0.81665493
136MP0002184_abnormal_innervation0.81662503
137MP0008995_early_reproductive_senescence0.81412314
138MP0006054_spinal_hemorrhage0.81399296
139MP0000428_abnormal_craniofacial_morphol0.81246612
140MP0010630_abnormal_cardiac_muscle0.80594561
141MP0002085_abnormal_embryonic_tissue0.80539172
142MP0002925_abnormal_cardiovascular_devel0.80164745
143MP0001270_distended_abdomen0.80021691
144MP0001529_abnormal_vocalization0.79492465
145MP0006035_abnormal_mitochondrial_morpho0.78456890
146MP0001299_abnormal_eye_distance/0.78262570
147MP0000569_abnormal_digit_pigmentation0.77233820
148MP0001324_abnormal_eye_pigmentation0.75465961
149MP0001764_abnormal_homeostasis0.75347625
150MP0005171_absent_coat_pigmentation0.75197366
151MP0001672_abnormal_embryogenesis/_devel0.75182695
152MP0005380_embryogenesis_phenotype0.75182695
153MP0003861_abnormal_nervous_system0.74858983
154MP0005332_abnormal_amino_acid0.74847111
155MP0002088_abnormal_embryonic_growth/wei0.74081636
156MP0005330_cardiomyopathy0.73998103
157MP0003880_abnormal_central_pattern0.73874120
158MP0008932_abnormal_embryonic_tissue0.73667764
159MP0006138_congestive_heart_failure0.73614998
160MP0003984_embryonic_growth_retardation0.73518219
161MP0004147_increased_porphyrin_level0.73294996
162MP0000767_abnormal_smooth_muscle0.73119313
163MP0000749_muscle_degeneration0.72394017
164MP0004742_abnormal_vestibular_system0.72114154
165MP0005620_abnormal_muscle_contractility0.72001318
166MP0005379_endocrine/exocrine_gland_phen0.71739210
167MP0010329_abnormal_lipoprotein_level0.71679716
168MP0003959_abnormal_lean_body0.71661906
169MP0005367_renal/urinary_system_phenotyp0.71031646
170MP0000516_abnormal_urinary_system0.71031646
171MP0004085_abnormal_heartbeat0.70296815
172MP0001346_abnormal_lacrimal_gland0.70250464
173MP0000432_abnormal_head_morphology0.69848029
174MP0000266_abnormal_heart_morphology0.68099962
175MP0001188_hyperpigmentation0.67995440
176MP0005508_abnormal_skeleton_morphology0.66576600
177MP0008057_abnormal_DNA_replication0.65545697

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)5.06913768
2Hepatoblastoma (HP:0002884)4.87617098
3Hypoglycemic seizures (HP:0002173)4.64188730
4Diastasis recti (HP:0001540)4.43339051
5Progressive cerebellar ataxia (HP:0002073)4.22562519
6Gaze-evoked nystagmus (HP:0000640)4.21750061
7Muscle fiber inclusion bodies (HP:0100299)4.05866782
8Nemaline bodies (HP:0003798)3.95838072
9Pancreatic cysts (HP:0001737)3.87056889
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.85093838
11Dysmetric saccades (HP:0000641)3.78926599
12Pancreatic islet-cell hyperplasia (HP:0004510)3.78826654
13Hyperventilation (HP:0002883)3.68133934
14True hermaphroditism (HP:0010459)3.54967908
15Pancreatic fibrosis (HP:0100732)3.44029419
16Nephroblastoma (Wilms tumor) (HP:0002667)3.43458479
17Embryonal renal neoplasm (HP:0011794)3.35228417
18Distal arthrogryposis (HP:0005684)3.33241875
19Renal duplication (HP:0000075)3.29757796
20Short 4th metacarpal (HP:0010044)3.13519657
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.13519657
22Symptomatic seizures (HP:0011145)3.09173897
23Attenuation of retinal blood vessels (HP:0007843)3.06749618
24Congenital stationary night blindness (HP:0007642)3.03158968
25Absence seizures (HP:0002121)2.95752140
26Molar tooth sign on MRI (HP:0002419)2.92996852
27Abnormality of midbrain morphology (HP:0002418)2.92996852
28Dialeptic seizures (HP:0011146)2.87750984
29Pendular nystagmus (HP:0012043)2.84085666
30Asymmetry of the thorax (HP:0001555)2.83463637
31Action tremor (HP:0002345)2.82697118
32Abnormality of the renal cortex (HP:0011035)2.82565378
33Bifid tongue (HP:0010297)2.76606727
34Double outlet right ventricle (HP:0001719)2.75547721
35Congenital malformation of the right heart (HP:0011723)2.75547721
36Nephronophthisis (HP:0000090)2.73314966
37Focal seizures (HP:0007359)2.72025287
38Areflexia of lower limbs (HP:0002522)2.70221288
39Febrile seizures (HP:0002373)2.69603665
40Abnormality of the pancreatic islet cells (HP:0006476)2.65083609
41Abnormality of endocrine pancreas physiology (HP:0012093)2.65083609
42Enlarged kidneys (HP:0000105)2.63008138
43Chronic hepatic failure (HP:0100626)2.61060452
44Calf muscle hypertrophy (HP:0008981)2.59715739
45Abnormal pancreas size (HP:0012094)2.58287758
46Agitation (HP:0000713)2.56223139
47Abolished electroretinogram (ERG) (HP:0000550)2.55071317
48Exercise-induced myalgia (HP:0003738)2.54120074
49Decreased circulating renin level (HP:0003351)2.52432432
50Prostate neoplasm (HP:0100787)2.50047699
51Exercise-induced muscle cramps (HP:0003710)2.46612587
52Microglossia (HP:0000171)2.45604083
53Abnormality of the 4th metacarpal (HP:0010012)2.44810898
54Keratoconus (HP:0000563)2.44399762
55Increased corneal curvature (HP:0100692)2.44399762
56Aplasia of the musculature (HP:0100854)2.42257804
57Abnormality of the renal medulla (HP:0100957)2.42240787
58Short middle phalanx of the 5th finger (HP:0004220)2.41356346
59Facial diplegia (HP:0001349)2.41185242
60Bony spicule pigmentary retinopathy (HP:0007737)2.40621145
61Urinary bladder sphincter dysfunction (HP:0002839)2.37035163
62Cystic liver disease (HP:0006706)2.36007296
63Fair hair (HP:0002286)2.34582376
64Mesomelia (HP:0003027)2.34461651
65Adrenal hypoplasia (HP:0000835)2.33890192
66Medial flaring of the eyebrow (HP:0010747)2.33323040
67Short 5th finger (HP:0009237)2.32460955
68Hypoplastic left heart (HP:0004383)2.31174745
69Supernumerary spleens (HP:0009799)2.30170399
70Abnormality of the hepatic vasculature (HP:0006707)2.30101843
71Focal motor seizures (HP:0011153)2.27965706
72Muscle hypertrophy of the lower extremities (HP:0008968)2.27624434
73Broad thumb (HP:0011304)2.27592122
74Abnormal connection of the cardiac segments (HP:0011545)2.25900446
75Abnormal ventriculo-arterial connection (HP:0011563)2.25900446
76Transposition of the great arteries (HP:0001669)2.25900446
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.23623875
78Limb dystonia (HP:0002451)2.23585539
79Abnormality of macular pigmentation (HP:0008002)2.22201204
80Male pseudohermaphroditism (HP:0000037)2.20809232
81Polydipsia (HP:0001959)2.14814148
82Abnormal drinking behavior (HP:0030082)2.14814148
83Absent speech (HP:0001344)2.14116539
84Broad finger (HP:0001500)2.12743502
85Abnormality of the phalanges of the hallux (HP:0010057)2.12351802
86Abnormality of the labia minora (HP:0012880)2.11838082
87Aplasia/Hypoplasia of the tongue (HP:0010295)2.11714422
88Cutaneous finger syndactyly (HP:0010554)2.11656881
89Type 1 muscle fiber predominance (HP:0003803)2.11251370
90Hemiparesis (HP:0001269)2.10419715
91Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.09651366
92Decreased central vision (HP:0007663)2.08929376
93Postural instability (HP:0002172)2.07876094
94Renal cortical cysts (HP:0000803)2.07298261
95Sclerocornea (HP:0000647)2.06651998
96Broad phalanges of the hand (HP:0009768)2.05154451
97Tubular atrophy (HP:0000092)2.04423771
98Dysdiadochokinesis (HP:0002075)2.04000806
99Type II lissencephaly (HP:0007260)2.03400321
100Round ear (HP:0100830)2.02834363
101Broad toe (HP:0001837)2.00990394
102Lipid accumulation in hepatocytes (HP:0006561)1.98561874
103Retinitis pigmentosa (HP:0000510)1.98400905
104Broad-based gait (HP:0002136)1.97875616
105Patellar aplasia (HP:0006443)1.97672513
106Broad phalanx (HP:0006009)1.97038179
107Absent phalangeal crease (HP:0006109)1.96533370
108Large for gestational age (HP:0001520)1.96332286
109Hypothermia (HP:0002045)1.96172740
110Clumsiness (HP:0002312)1.95611788
111Abnormality of alanine metabolism (HP:0010916)1.94241709
112Hyperalaninemia (HP:0003348)1.94241709
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94241709
114Severe visual impairment (HP:0001141)1.93119825
115Hyperglycinuria (HP:0003108)1.92963733
116Preauricular pit (HP:0004467)1.92138342
117Periauricular skin pits (HP:0100277)1.92138342
118Increased hepatocellular lipid droplets (HP:0006565)1.92072943
119Ketoacidosis (HP:0001993)1.90499133
120Central scotoma (HP:0000603)1.89279914
121Protruding tongue (HP:0010808)1.88773769
122Hypoplastic ischia (HP:0003175)1.87667439
123Absent/shortened dynein arms (HP:0200106)1.87546011
124Dynein arm defect of respiratory motile cilia (HP:0012255)1.87546011
125Heterochromia iridis (HP:0001100)1.87303214
126Abnormality of the fetal cardiovascular system (HP:0010948)1.87166269
127Abnormal umbilical cord blood vessels (HP:0011403)1.87166269
128Single umbilical artery (HP:0001195)1.87166269
129Furrowed tongue (HP:0000221)1.87134505
130Abnormal rod and cone electroretinograms (HP:0008323)1.86761838
131Aplasia/Hypoplasia of the patella (HP:0006498)1.86075491
132Generalized hypopigmentation of hair (HP:0011358)1.86013624
133Myelomeningocele (HP:0002475)1.85695144
134Abnormality of the calf musculature (HP:0001430)1.85487652
135Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.83861179
136Abnormality of dentin (HP:0010299)1.83801507
137Congenital hepatic fibrosis (HP:0002612)1.83650463
138Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.82754187
139Abnormal biliary tract physiology (HP:0012439)1.82689635
140Bile duct proliferation (HP:0001408)1.82689635
141Menstrual irregularities (HP:0000858)1.82465556
142Aplasia/Hypoplasia of the fovea (HP:0008060)1.80874532
143Hypoplasia of the fovea (HP:0007750)1.80874532
144Absent hand (HP:0004050)1.80755933
145Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80383101
146Midline defect of the nose (HP:0004122)1.79747395
147Abnormal finger flexion creases (HP:0006143)1.79432275
148Metaphyseal dysplasia (HP:0100255)1.79249014
149Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78262998
150Hypoplastic heart (HP:0001961)1.77769223
151Genital tract atresia (HP:0001827)1.77469337
152Cutaneous syndactyly (HP:0012725)1.77454970
153Chorioretinal atrophy (HP:0000533)1.77216667
154Aplasia/Hypoplasia involving the musculature (HP:0001460)1.76713811
155Inability to walk (HP:0002540)1.76408970
156Broad long bones (HP:0005622)1.76268051
157Papillary thyroid carcinoma (HP:0002895)1.75953285
158Diaphragmatic weakness (HP:0009113)1.74682776
159Hyperaldosteronism (HP:0000859)1.74673986
160Renal salt wasting (HP:0000127)1.74541331
161Gait imbalance (HP:0002141)1.74140053
162Type 2 muscle fiber atrophy (HP:0003554)1.73848330
163Neoplasm of the adrenal gland (HP:0100631)1.72992339
164Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72458995
165Abnormal number of incisors (HP:0011064)1.72058772
166Papilledema (HP:0001085)1.71915167
167Hyperkalemia (HP:0002153)1.71913764
168Abnormality of the phalanges of the 5th finger (HP:0004213)1.69730099
169Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.69664931
170Rimmed vacuoles (HP:0003805)1.69568986
171Abnormality of the aortic arch (HP:0012303)1.68716996
172Labial hypoplasia (HP:0000066)1.67516566
173Hyperinsulinemic hypoglycemia (HP:0000825)1.66017009
174Vitreoretinal degeneration (HP:0000655)1.65798757
175Downturned corners of mouth (HP:0002714)1.65011222
176Intestinal polyposis (HP:0200008)1.64707274
177Acute necrotizing encephalopathy (HP:0006965)1.64311912
178Growth hormone deficiency (HP:0000824)1.64111862
179Spinal cord lesions (HP:0100561)1.63953590
180Syringomyelia (HP:0003396)1.63953590
181Fibular aplasia (HP:0002990)1.63325649
182Cavernous hemangioma (HP:0001048)1.62062537
183Abnormality of the radial head (HP:0003995)1.61855718
184Absent eyebrow (HP:0002223)1.61759348
185Congenital sensorineural hearing impairment (HP:0008527)1.61262307
186Ectopic anus (HP:0004397)1.60865333
187Ectopic kidney (HP:0000086)1.60579645
188Embryonal neoplasm (HP:0002898)1.60400549
189Hypoplastic female external genitalia (HP:0012815)1.60122333
190Abdominal situs inversus (HP:0003363)1.59718169
191Abnormality of abdominal situs (HP:0011620)1.59718169
192Neoplasm of the liver (HP:0002896)1.59594842
193Broad palm (HP:0001169)1.58780971
194Tracheomalacia (HP:0002779)1.56299643

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.72976463
2WNK35.88801587
3OBSCN3.60572590
4AKT32.99191727
5PINK12.69459887
6CDK192.67538796
7OXSR12.66898449
8STK38L2.65626738
9SRPK12.60497290
10TIE12.59181591
11NUAK12.36576700
12BCR2.35216561
13PNCK2.27392389
14CDC72.27144094
15ACVR1B2.25752371
16KDR2.25489498
17WNK42.23982230
18LATS22.10110752
19PHKG22.06430588
20PHKG12.06430588
21GRK12.01165574
22EPHB21.97979780
23MAP4K21.96048529
24NTRK21.70978230
25PIK3CG1.67723725
26KSR11.66192875
27BUB11.65139696
28ERBB31.58663896
29UHMK11.53188186
30MAPK131.50345987
31MINK11.42755971
32MKNK11.35815995
33SIK31.35813807
34MKNK21.33383266
35TGFBR11.30975788
36MAP3K41.30621254
37PASK1.29973820
38STK241.22138704
39CSNK1G31.21663284
40TRIM281.21417283
41IRAK21.21199275
42BMPR1B1.20608164
43MAP3K101.20034800
44PAK31.19025479
45PRKD31.14477332
46MAPKAPK31.14428606
47MAP3K71.13259597
48NEK61.12855361
49CASK1.10859317
50MUSK1.10607291
51TAOK31.08266817
52BRSK21.04740197
53LATS11.03256721
54TNK21.02080927
55CSNK1G10.99742314
56TXK0.99582458
57PLK30.98887423
58BRSK10.98762777
59MELK0.95140861
60FGFR20.94945273
61CHEK20.94765262
62CDK80.93158152
63FER0.92678276
64ADRBK20.91425160
65YES10.87763835
66DAPK20.86241072
67PLK20.84785398
68WNK10.84036454
69TNIK0.83396461
70PTK2B0.83205610
71EIF2AK30.80150891
72PDGFRA0.79864439
73CLK10.79249361
74DMPK0.79021237
75STK390.78864298
76PLK40.77274279
77PRKCE0.76886841
78MYLK0.76243019
79CSNK1A1L0.75485383
80PDK20.74355488
81BRAF0.73930746
82TLK10.72551792
83FGFR10.71240135
84PRKAA20.69908118
85STK30.69537095
86CAMK1G0.67052234
87MAPK150.66868741
88DYRK30.65985094
89IRAK10.65625251
90EPHA40.63839754
91ZAK0.62639761
92CDK140.62032832
93CSNK1G20.61649277
94TRPM70.61220605
95DYRK20.61017384
96CDC42BPA0.60825985
97PRKCG0.59757109
98LIMK10.58477306
99GRK50.58149853
100MARK10.56892245
101PIK3CA0.56333652
102INSRR0.56102509
103NTRK30.55932151
104PKN10.53846534
105NEK20.52640355
106WEE10.52031448
107CDK30.51481287
108MAPKAPK50.50934230
109CDK180.49960684
110PLK10.48905860
111ERBB40.45541437
112PRKG10.44840701
113PRKACA0.44635574
114NME10.43990801
115NEK10.43522291
116PRKAA10.43355385
117PTK20.42944335
118BCKDK0.42289715
119MAP2K10.42118356
120MARK30.41476728
121ILK0.41314178
122TYRO30.40752848
123MTOR0.40706446
124TEC0.40317097
125CCNB10.40314472
126PRKG20.40059978
127CSNK2A10.39870248
128STK110.39061806
129ATM0.38731141
130CSNK1D0.37827826
131CDK10.36989444
132VRK10.36761867
133ADRBK10.36147188
134RPS6KA40.35033094
135CDK150.34012368
136MAP2K40.33915762
137MAP2K60.33685762
138PRKACB0.33056553
139MST40.33041589
140CAMK2D0.32217050
141CSNK1A10.31911811
142ROCK10.31463492
143MAP2K70.31439512
144ICK0.31376384
145STK380.30641814
146BRD40.30640974
147AURKB0.30292053
148CHEK10.30215155
149NLK0.30206580
150MAP3K120.29769995
151RPS6KB10.29125535
152CAMK2A0.28625370
153BLK0.28135248
154MAPK120.27850596
155EIF2AK20.25091782
156PDK10.24420868
157ERBB20.24112298
158PRKCA0.23864861
159DYRK1A0.22514459

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.69956598
2Butanoate metabolism_Homo sapiens_hsa006503.23939430
3Parkinsons disease_Homo sapiens_hsa050122.81219513
4Hedgehog signaling pathway_Homo sapiens_hsa043402.75323650
5Oxidative phosphorylation_Homo sapiens_hsa001902.71698669
6Cardiac muscle contraction_Homo sapiens_hsa042602.63111180
7Tryptophan metabolism_Homo sapiens_hsa003802.57720542
8Propanoate metabolism_Homo sapiens_hsa006402.54978426
9Basal cell carcinoma_Homo sapiens_hsa052172.53072525
10Huntingtons disease_Homo sapiens_hsa050162.42994121
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.35486835
12Phototransduction_Homo sapiens_hsa047442.30394860
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.28751432
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.25098706
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12295933
16Linoleic acid metabolism_Homo sapiens_hsa005912.07487688
17Nitrogen metabolism_Homo sapiens_hsa009102.05868114
18Protein export_Homo sapiens_hsa030601.97601599
19Hippo signaling pathway_Homo sapiens_hsa043901.92766808
20Spliceosome_Homo sapiens_hsa030401.92031371
21Cell cycle_Homo sapiens_hsa041101.91148596
22Alzheimers disease_Homo sapiens_hsa050101.88801083
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88377226
24Axon guidance_Homo sapiens_hsa043601.85137605
25Melanogenesis_Homo sapiens_hsa049161.84549741
26Ribosome_Homo sapiens_hsa030101.70759522
27ABC transporters_Homo sapiens_hsa020101.67930090
28Dilated cardiomyopathy_Homo sapiens_hsa054141.66830215
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66727514
30Wnt signaling pathway_Homo sapiens_hsa043101.64563015
31RNA polymerase_Homo sapiens_hsa030201.64344357
32Olfactory transduction_Homo sapiens_hsa047401.64238067
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.64033651
34Oocyte meiosis_Homo sapiens_hsa041141.63126307
35Selenocompound metabolism_Homo sapiens_hsa004501.63090798
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.63055691
37mRNA surveillance pathway_Homo sapiens_hsa030151.55431048
38RNA degradation_Homo sapiens_hsa030181.54416220
39GABAergic synapse_Homo sapiens_hsa047271.51458731
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48114562
41Fatty acid degradation_Homo sapiens_hsa000711.43853450
42Basal transcription factors_Homo sapiens_hsa030221.43232838
43Circadian rhythm_Homo sapiens_hsa047101.42018170
44Cocaine addiction_Homo sapiens_hsa050301.41824462
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40862546
46Retinol metabolism_Homo sapiens_hsa008301.39107380
47TGF-beta signaling pathway_Homo sapiens_hsa043501.38248980
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37644811
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36292517
50Caffeine metabolism_Homo sapiens_hsa002321.36221387
51Serotonergic synapse_Homo sapiens_hsa047261.35690679
52beta-Alanine metabolism_Homo sapiens_hsa004101.35056817
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.33293159
54Nicotine addiction_Homo sapiens_hsa050331.32075815
55Calcium signaling pathway_Homo sapiens_hsa040201.28304500
56Homologous recombination_Homo sapiens_hsa034401.27845449
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27243384
58Chemical carcinogenesis_Homo sapiens_hsa052041.27124073
59Adherens junction_Homo sapiens_hsa045201.25219248
60Long-term depression_Homo sapiens_hsa047301.24937402
61Proteasome_Homo sapiens_hsa030501.23872490
62Histidine metabolism_Homo sapiens_hsa003401.21323475
63RNA transport_Homo sapiens_hsa030131.17050666
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15325265
65Taste transduction_Homo sapiens_hsa047421.15050555
66Maturity onset diabetes of the young_Homo sapiens_hsa049501.14967886
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14346805
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13047185
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10184467
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09535213
71Renal cell carcinoma_Homo sapiens_hsa052111.08420190
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08080763
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07438691
74Tight junction_Homo sapiens_hsa045301.05266473
75Amphetamine addiction_Homo sapiens_hsa050311.04861568
76Salivary secretion_Homo sapiens_hsa049701.04238397
77Peroxisome_Homo sapiens_hsa041461.03714589
78Alcoholism_Homo sapiens_hsa050341.03593748
79Dopaminergic synapse_Homo sapiens_hsa047281.03295317
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02108221
81Glycerolipid metabolism_Homo sapiens_hsa005611.00815307
82Fatty acid metabolism_Homo sapiens_hsa012120.97861058
83MicroRNAs in cancer_Homo sapiens_hsa052060.97327610
84Insulin secretion_Homo sapiens_hsa049110.95714136
85Fanconi anemia pathway_Homo sapiens_hsa034600.95053608
86Proteoglycans in cancer_Homo sapiens_hsa052050.92212240
87Mismatch repair_Homo sapiens_hsa034300.91630237
88Circadian entrainment_Homo sapiens_hsa047130.89720084
89Glucagon signaling pathway_Homo sapiens_hsa049220.85494380
90Lysine degradation_Homo sapiens_hsa003100.85407895
91Non-homologous end-joining_Homo sapiens_hsa034500.85221795
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.83480029
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83362215
94Prostate cancer_Homo sapiens_hsa052150.83226248
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82726852
96Fatty acid biosynthesis_Homo sapiens_hsa000610.82014742
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81886224
98Arachidonic acid metabolism_Homo sapiens_hsa005900.81643186
99Ovarian steroidogenesis_Homo sapiens_hsa049130.80642420
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80611822
101Renin secretion_Homo sapiens_hsa049240.80025104
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.79273691
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78922627
104Morphine addiction_Homo sapiens_hsa050320.78289165
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77114375
106DNA replication_Homo sapiens_hsa030300.77096882
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76922305
108Regulation of autophagy_Homo sapiens_hsa041400.76675390
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75709505
110Pyrimidine metabolism_Homo sapiens_hsa002400.73195663
111Focal adhesion_Homo sapiens_hsa045100.73064301
112Type I diabetes mellitus_Homo sapiens_hsa049400.72834462
113Gap junction_Homo sapiens_hsa045400.71547187
114Fat digestion and absorption_Homo sapiens_hsa049750.70881872
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70172355
116Gastric acid secretion_Homo sapiens_hsa049710.68937654
117Oxytocin signaling pathway_Homo sapiens_hsa049210.68673516
118Colorectal cancer_Homo sapiens_hsa052100.67898452
119Pathways in cancer_Homo sapiens_hsa052000.67468758
120Ether lipid metabolism_Homo sapiens_hsa005650.66041319
121Vibrio cholerae infection_Homo sapiens_hsa051100.65324970
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64986019
123Estrogen signaling pathway_Homo sapiens_hsa049150.62661686
124Metabolic pathways_Homo sapiens_hsa011000.62096721
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61561657
126PPAR signaling pathway_Homo sapiens_hsa033200.59570828
127One carbon pool by folate_Homo sapiens_hsa006700.58633960
128Rap1 signaling pathway_Homo sapiens_hsa040150.57844451
129Purine metabolism_Homo sapiens_hsa002300.57783774
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57722035
131HIF-1 signaling pathway_Homo sapiens_hsa040660.55511929
132Dorso-ventral axis formation_Homo sapiens_hsa043200.55483631
133Arginine and proline metabolism_Homo sapiens_hsa003300.55378621
134Pyruvate metabolism_Homo sapiens_hsa006200.54863165
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54526618
136Starch and sucrose metabolism_Homo sapiens_hsa005000.54524845
137Cyanoamino acid metabolism_Homo sapiens_hsa004600.53366463
138Glutathione metabolism_Homo sapiens_hsa004800.53188493
139Epstein-Barr virus infection_Homo sapiens_hsa051690.52898623
140Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52167755
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51844829
142Bile secretion_Homo sapiens_hsa049760.50863890
143Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50854202
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.50073816
145Sphingolipid metabolism_Homo sapiens_hsa006000.49635876
146Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49410104
147HTLV-I infection_Homo sapiens_hsa051660.48679279
148Cholinergic synapse_Homo sapiens_hsa047250.47086632
149Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46433147
150PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46188674
151Sulfur metabolism_Homo sapiens_hsa009200.45761534
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44316843
153Ras signaling pathway_Homo sapiens_hsa040140.44212142
154N-Glycan biosynthesis_Homo sapiens_hsa005100.43720621
155Long-term potentiation_Homo sapiens_hsa047200.43195010
156Glutamatergic synapse_Homo sapiens_hsa047240.42893512
157Systemic lupus erythematosus_Homo sapiens_hsa053220.42460431
158Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42090285
159Endometrial cancer_Homo sapiens_hsa052130.41554806
160Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41552627
161Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41335008
162Thyroid hormone synthesis_Homo sapiens_hsa049180.36498172
163cAMP signaling pathway_Homo sapiens_hsa040240.35466884
164Bladder cancer_Homo sapiens_hsa052190.34942727
165Thyroid cancer_Homo sapiens_hsa052160.32713134

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