ASB6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. Alternatively spliced transcript variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GDP-mannose metabolic process (GO:0019673)5.32386114
2cell migration in hindbrain (GO:0021535)5.28186856
3behavioral response to nicotine (GO:0035095)5.27607383
4cellular response to ATP (GO:0071318)5.12292070
5viral transcription (GO:0019083)4.99914252
6regulation of synapse structural plasticity (GO:0051823)4.71037416
7DNA deamination (GO:0045006)4.68660099
8translational termination (GO:0006415)4.68605886
9positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.09563740
10translational elongation (GO:0006414)4.06210651
11ribosomal small subunit assembly (GO:0000028)4.02372053
12pattern specification involved in kidney development (GO:0061004)3.93595335
13opioid receptor signaling pathway (GO:0038003)3.92381696
14viral life cycle (GO:0019058)3.91837885
15negative regulation of cell aging (GO:0090344)3.89466741
16telomere maintenance via semi-conservative replication (GO:0032201)3.85162096
17adenosine receptor signaling pathway (GO:0001973)3.84441537
18protein insertion into membrane (GO:0051205)3.78100800
19cellular protein complex disassembly (GO:0043624)3.75224029
20DNA strand elongation involved in DNA replication (GO:0006271)3.69894850
21DNA strand elongation (GO:0022616)3.68630387
22purinergic nucleotide receptor signaling pathway (GO:0035590)3.65992598
23mannose metabolic process (GO:0006013)3.61806811
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.60385286
25DNA replication initiation (GO:0006270)3.58312850
26establishment of protein localization to mitochondrial membrane (GO:0090151)3.52185261
27ribosome biogenesis (GO:0042254)3.49737822
28folic acid metabolic process (GO:0046655)3.46964172
29maturation of SSU-rRNA (GO:0030490)3.46014453
30meiotic chromosome segregation (GO:0045132)3.43124113
31DNA replication checkpoint (GO:0000076)3.42862567
32telomere maintenance via recombination (GO:0000722)3.41992431
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.38654944
34protein complex disassembly (GO:0043241)3.37750423
35protein targeting to ER (GO:0045047)3.34947683
36telomere maintenance via telomere lengthening (GO:0010833)3.34743182
37regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.34427043
38sequestering of actin monomers (GO:0042989)3.34362194
39cotranslational protein targeting to membrane (GO:0006613)3.33408884
40nucleobase biosynthetic process (GO:0046112)3.25048204
41viral protein processing (GO:0019082)3.23443371
42rRNA modification (GO:0000154)3.23221654
43startle response (GO:0001964)3.22447701
44segment specification (GO:0007379)3.19577763
45positive regulation of action potential (GO:0045760)3.17899906
46UV protection (GO:0009650)3.15549048
47establishment of protein localization to endoplasmic reticulum (GO:0072599)3.13477871
48IMP biosynthetic process (GO:0006188)3.13346218
49spinal cord motor neuron differentiation (GO:0021522)3.13335700
50ribonucleoprotein complex biogenesis (GO:0022613)3.13050624
51macromolecular complex disassembly (GO:0032984)3.09992560
52formation of translation preinitiation complex (GO:0001731)3.09600412
53regulation of nuclear cell cycle DNA replication (GO:0033262)3.07575678
54tRNA methylation (GO:0030488)3.06278104
55regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.05143381
56termination of RNA polymerase III transcription (GO:0006386)3.04989421
57transcription elongation from RNA polymerase III promoter (GO:0006385)3.04989421
58protein localization to endoplasmic reticulum (GO:0070972)3.04027705
59proteasome assembly (GO:0043248)3.02967903
60maturation of 5.8S rRNA (GO:0000460)3.02621350
61mitotic recombination (GO:0006312)3.02386686
62sensory perception of taste (GO:0050909)3.02174318
63deoxyribonucleotide biosynthetic process (GO:0009263)3.02014851
64positive regulation of protein kinase C signaling (GO:0090037)2.99709687
65pseudouridine synthesis (GO:0001522)2.96587764
66purinergic receptor signaling pathway (GO:0035587)2.94636748
67translational initiation (GO:0006413)2.92811569
68rRNA processing (GO:0006364)2.92674532
69transcription-coupled nucleotide-excision repair (GO:0006283)2.90756855
70ribosomal large subunit biogenesis (GO:0042273)2.90522860
71G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.90468829
727-methylguanosine mRNA capping (GO:0006370)2.88877920
73purine nucleobase biosynthetic process (GO:0009113)2.87634520
74peptidyl-histidine modification (GO:0018202)2.87312356
75lens fiber cell differentiation (GO:0070306)2.87211549
76rRNA metabolic process (GO:0016072)2.84947158
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.84731411
78positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.83912545
79ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.81932549
80spliceosomal snRNP assembly (GO:0000387)2.80579046
81regulation of respiratory gaseous exchange (GO:0043576)2.80139613
82RNA capping (GO:0036260)2.78875773
837-methylguanosine RNA capping (GO:0009452)2.78875773
84cell-cell junction maintenance (GO:0045217)2.78742534
85sympathetic nervous system development (GO:0048485)2.76909505
86negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.76280830
87mitotic metaphase plate congression (GO:0007080)2.76188586
88nucleotide-excision repair, DNA gap filling (GO:0006297)2.75662170
89ribosome assembly (GO:0042255)2.75198661
90tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.75182622
91RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.75182622
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.74840815
93neuronal stem cell maintenance (GO:0097150)2.72706538
94CENP-A containing nucleosome assembly (GO:0034080)2.72473573
95positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.71729554
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70335717
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69423511
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.69244060
99mitochondrial respiratory chain complex I assembly (GO:0032981)2.69244060
100NADH dehydrogenase complex assembly (GO:0010257)2.69244060
101nucleoside transmembrane transport (GO:1901642)2.68447945
102ribosomal small subunit biogenesis (GO:0042274)2.68160059
103substrate-independent telencephalic tangential migration (GO:0021826)2.68092156
104substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.68092156
105rRNA methylation (GO:0031167)2.68018818
106regulation of translation in response to stress (GO:0043555)2.67907642
107regulation of double-strand break repair via homologous recombination (GO:0010569)2.64674187
108phosphatidylglycerol biosynthetic process (GO:0006655)2.64160932
109negative regulation of ligase activity (GO:0051352)2.63307965
110negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.63307965
111telomere organization (GO:0032200)2.62392661
112chromatin remodeling at centromere (GO:0031055)2.61808848
113telomere maintenance (GO:0000723)2.61693108
114neuron fate specification (GO:0048665)2.61066992
115antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.60431535
116response to ATP (GO:0033198)2.59761404
117kinetochore assembly (GO:0051382)2.59751099
118regulation of protein kinase A signaling (GO:0010738)2.59459375
119mismatch repair (GO:0006298)2.59243416
120cullin deneddylation (GO:0010388)2.59214312
121retinal ganglion cell axon guidance (GO:0031290)2.58959365
122DNA strand renaturation (GO:0000733)2.58800547
123signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.58678223
124signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.58678223
125signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.58678223
126CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.57955306
127DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.57409003
128negative regulation of macroautophagy (GO:0016242)2.57402159
129synaptic transmission, cholinergic (GO:0007271)2.57336801
130antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.57201038
131mitochondrion morphogenesis (GO:0070584)2.57049970
132cell cycle G1/S phase transition (GO:0044843)2.56691464
133G1/S transition of mitotic cell cycle (GO:0000082)2.56691464
134DNA unwinding involved in DNA replication (GO:0006268)2.55451937
135heart valve formation (GO:0003188)2.54194712
136intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.53714344
137signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.53714344
138mitotic nuclear envelope disassembly (GO:0007077)2.53684787
139neuromuscular synaptic transmission (GO:0007274)2.53535108
140mitotic cell cycle arrest (GO:0071850)2.53264224
141transcription from RNA polymerase I promoter (GO:0006360)2.52765049
142protein K6-linked ubiquitination (GO:0085020)2.52673735
143prepulse inhibition (GO:0060134)2.52319254
144cellular component biogenesis (GO:0044085)2.52265787
145protein deneddylation (GO:0000338)2.50948837
146cranial nerve development (GO:0021545)2.50862301
147atrial septum morphogenesis (GO:0060413)2.50119038
148ncRNA processing (GO:0034470)2.49899942
149termination of RNA polymerase I transcription (GO:0006363)2.49506229
150base-excision repair, AP site formation (GO:0006285)2.49406049
151peristalsis (GO:0030432)2.49393064
152signal transduction involved in cell cycle checkpoint (GO:0072395)2.49327997
153signal transduction involved in DNA damage checkpoint (GO:0072422)2.48717841
154signal transduction involved in DNA integrity checkpoint (GO:0072401)2.48717841
155dopaminergic neuron differentiation (GO:0071542)2.47960766
156transcription elongation from RNA polymerase I promoter (GO:0006362)2.46910099
157virion assembly (GO:0019068)2.46375599
158tRNA modification (GO:0006400)2.46177781
159sex determination (GO:0007530)2.46113322
160negative regulation of mast cell activation (GO:0033004)2.45015286
161viral mRNA export from host cell nucleus (GO:0046784)2.44494078
162urogenital system development (GO:0001655)2.43552290
163negative regulation of telomere maintenance (GO:0032205)2.43293116
164gamma-aminobutyric acid transport (GO:0015812)2.43170997
165folic acid-containing compound biosynthetic process (GO:0009396)2.43086472
166spliceosomal complex assembly (GO:0000245)2.43057917
167deoxyribose phosphate biosynthetic process (GO:0046385)2.42656159
1682-deoxyribonucleotide biosynthetic process (GO:0009265)2.42656159
169ncRNA metabolic process (GO:0034660)2.42482085
170urinary tract smooth muscle contraction (GO:0014848)2.42426736
171kinetochore organization (GO:0051383)2.41972639
172negative regulation of Notch signaling pathway (GO:0045746)2.41413781
173metallo-sulfur cluster assembly (GO:0031163)2.41311161
174iron-sulfur cluster assembly (GO:0016226)2.41311161
175mRNA catabolic process (GO:0006402)2.41198569
176negative regulation of interleukin-1 beta production (GO:0032691)2.40460183
177protein targeting to membrane (GO:0006612)2.40247841
178regulation of synaptic transmission, dopaminergic (GO:0032225)2.40179481
179RNA methylation (GO:0001510)2.39352029
180tRNA aminoacylation for protein translation (GO:0006418)2.39124562
181exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.39033010
182regulation of protein heterodimerization activity (GO:0043497)2.38179850
183positive regulation of gamma-delta T cell activation (GO:0046645)2.37626437
184intra-S DNA damage checkpoint (GO:0031573)2.37313533
185DNA catabolic process, exonucleolytic (GO:0000738)2.36331697
186leukocyte aggregation (GO:0070486)2.36248110
187amino acid activation (GO:0043038)2.36011108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.29960492
2* MYC_18555785_ChIP-Seq_MESCs_Mouse3.66363700
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49546210
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.37667060
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.20292751
6* GABP_17652178_ChIP-ChIP_JURKAT_Human3.14190704
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.12608328
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.07592913
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.89453494
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.82738798
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.72379831
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70333468
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.68992613
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.67270516
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67059639
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58407594
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57750031
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55050634
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.54923816
20* P68_20966046_ChIP-Seq_HELA_Human2.47048622
21EZH2_22144423_ChIP-Seq_EOC_Human2.44649621
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.41862488
23* LXR_22292898_ChIP-Seq_THP-1_Human2.41372077
24CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.38696611
25TET1_21451524_ChIP-Seq_MESCs_Mouse2.33472016
26VDR_23849224_ChIP-Seq_CD4+_Human2.29682138
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.29474245
28* ERG_21242973_ChIP-ChIP_JURKAT_Human2.17147773
29XRN2_22483619_ChIP-Seq_HELA_Human2.15870086
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13077696
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13008979
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12185541
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01952442
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98389190
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.97969957
36FOXP3_21729870_ChIP-Seq_TREG_Human1.97580298
37* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96597620
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.93682009
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.93633517
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.93007945
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.92969152
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92254766
43BCL6_27268052_Chip-Seq_Bcells_Human1.90024881
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.88774916
45CTCF_27219007_Chip-Seq_Bcells_Human1.87811954
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85305543
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84096965
48DCP1A_22483619_ChIP-Seq_HELA_Human1.83553062
49* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83314993
50CIITA_25753668_ChIP-Seq_RAJI_Human1.83268643
51BCOR_27268052_Chip-Seq_Bcells_Human1.82550109
52* GABP_19822575_ChIP-Seq_HepG2_Human1.82293207
53* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82280630
54MAF_26560356_Chip-Seq_TH2_Human1.80089993
55RACK7_27058665_Chip-Seq_MCF-7_Human1.79719744
56PHF8_20622854_ChIP-Seq_HELA_Human1.79136218
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78814037
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.76733382
59E2F1_20622854_ChIP-Seq_HELA_Human1.75624480
60MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.74476248
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.74048152
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73834995
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73107633
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.72885534
65ELK1_19687146_ChIP-ChIP_HELA_Human1.70061463
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70043732
67MYC_22102868_ChIP-Seq_BL_Human1.69571559
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.69088045
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68937638
70* SMC4_20622854_ChIP-Seq_HELA_Human1.68830038
71TTF2_22483619_ChIP-Seq_HELA_Human1.68588270
72FOXP1_21924763_ChIP-Seq_HESCs_Human1.68152900
73KDM2B_26808549_Chip-Seq_DND41_Human1.67490546
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66939524
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65214848
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64816378
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.60757095
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56293587
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.56154814
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54202553
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53366343
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51269333
83RARB_24833708_ChIP-Seq_LIVER_Mouse1.50079763
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.48369382
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47441159
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47271570
87IRF8_22096565_ChIP-ChIP_GC-B_Human1.46567547
88* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44926502
89SPI1_23547873_ChIP-Seq_NB4_Human1.44725701
90MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.43501645
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42204315
92KDM2B_26808549_Chip-Seq_K562_Human1.41934773
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.41405123
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41286881
95RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40200642
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.40181951
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39701834
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39678987
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39301802
100RARA_24833708_ChIP-Seq_LIVER_Mouse1.39262719
101CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37985685
102EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.37039922
103TP53_22127205_ChIP-Seq_IMR90_Human1.36402247
104EZH2_27294783_Chip-Seq_ESCs_Mouse1.35721567
105TP63_19390658_ChIP-ChIP_HaCaT_Human1.35440426
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34606123
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33529470
108SA1_27219007_Chip-Seq_Bcells_Human1.33489162
109CREB1_26743006_Chip-Seq_LNCaP_Human1.33436882
110TFEB_21752829_ChIP-Seq_HELA_Human1.33232989
111SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31111358
112VDR_21846776_ChIP-Seq_THP-1_Human1.30981088
113VDR_24763502_ChIP-Seq_THP-1_Human1.29951783
114* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29217954
115STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29108866
116CTCF_20526341_ChIP-Seq_ESCs_Human1.29078305
117CTCF_21964334_Chip-Seq_Bcells_Human1.28673957
118TP53_20018659_ChIP-ChIP_R1E_Mouse1.28276977
119YY1_22570637_ChIP-Seq_MALME-3M_Human1.28194893
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.28131929
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27941836
122KDM5A_27292631_Chip-Seq_BREAST_Human1.27092151
123E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27079263
124SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.26949369
125* CTCF_26484167_Chip-Seq_Bcells_Mouse1.26578917
126MAF_26560356_Chip-Seq_TH1_Human1.26504487
127ERA_21632823_ChIP-Seq_H3396_Human1.24005300
128SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23888261
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23748876
130OCT4_19829295_ChIP-Seq_ESCs_Human1.23140955
131TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.21625485
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21226333
133RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.19261547
134MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16961090
135JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14144928
136ETS1_21867929_ChIP-Seq_TH2_Mouse1.14092803
137* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12609415
138* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10771362
139KDM2B_26808549_Chip-Seq_JURKAT_Human1.10389351
140CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09954321
141PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09818852
142EZH2_27304074_Chip-Seq_ESCs_Mouse1.09197019
143RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09065695
144* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07176581
145FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07060794
146TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06952287
147GATA1_22025678_ChIP-Seq_K562_Human1.06428267
148* TP63_22573176_ChIP-Seq_HFKS_Human1.04456605
149ELK1_22589737_ChIP-Seq_MCF10A_Human1.03687980
150SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03602207
151CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03483536
152POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02543329
153CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02503053
154* RUNX1_22412390_ChIP-Seq_EML_Mouse1.01168754
155MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99422743
156KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98484687
157BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97698541
158CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94764433
159KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94197558
160DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93529176
161AR_21909140_ChIP-Seq_LNCAP_Human0.92333814
162PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91974599
163* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91652198
164E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91145604
165HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89713276
166SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89219007
167STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88896836
168SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87308140
169* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87291552
170MYB_26560356_Chip-Seq_TH1_Human0.86745951
171ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85171799
172MYB_26560356_Chip-Seq_TH2_Human0.85124124
173GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84827891

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous4.86954939
2MP0003693_abnormal_embryo_hatching3.84746917
3MP0000569_abnormal_digit_pigmentation3.80881308
4MP0003111_abnormal_nucleus_morphology3.57291106
5MP0005171_absent_coat_pigmentation3.34887589
6MP0010094_abnormal_chromosome_stability3.14026147
7MP0003077_abnormal_cell_cycle2.88033241
8MP0008058_abnormal_DNA_repair2.82850535
9MP0001835_abnormal_antigen_presentation2.73488964
10MP0002638_abnormal_pupillary_reflex2.72588820
11MP0008007_abnormal_cellular_replicative2.60379192
12MP0004957_abnormal_blastocyst_morpholog2.57921217
13MP0008057_abnormal_DNA_replication2.51541901
14MP0002396_abnormal_hematopoietic_system2.42565428
15MP0009333_abnormal_splenocyte_physiolog2.23736279
16MP0001502_abnormal_circadian_rhythm2.23077943
17MP0005671_abnormal_response_to2.22614249
18MP0001968_abnormal_touch/_nociception2.22328170
19MP0001986_abnormal_taste_sensitivity2.08185026
20MP0009785_altered_susceptibility_to2.08071412
21MP0002653_abnormal_ependyma_morphology1.99079728
22MP0002132_abnormal_respiratory_system1.98253108
23MP0000685_abnormal_immune_system1.97315661
24MP0009379_abnormal_foot_pigmentation1.95861280
25MP0002148_abnormal_hypersensitivity_rea1.93734901
26MP0003763_abnormal_thymus_physiology1.91527613
27MP0002398_abnormal_bone_marrow1.90660837
28MP0005397_hematopoietic_system_phenotyp1.89150299
29MP0001545_abnormal_hematopoietic_system1.89150299
30MP0001800_abnormal_humoral_immune1.84296563
31MP0000778_abnormal_nervous_system1.83684257
32MP0003786_premature_aging1.81451710
33MP0003436_decreased_susceptibility_to1.81174356
34MP0002452_abnormal_antigen_presenting1.79448448
35MP0000490_abnormal_crypts_of1.77633148
36MP0005000_abnormal_immune_tolerance1.76873582
37MP0000858_altered_metastatic_potential1.75831013
38MP0002723_abnormal_immune_serum1.74276178
39MP0001819_abnormal_immune_cell1.73897826
40MP0002420_abnormal_adaptive_immunity1.73706126
41MP0005025_abnormal_response_to1.70728946
42MP0005083_abnormal_biliary_tract1.67674625
43MP0008932_abnormal_embryonic_tissue1.63450634
44MP0000538_abnormal_urinary_bladder1.62364775
45MP0000750_abnormal_muscle_regeneration1.62237748
46MP0004808_abnormal_hematopoietic_stem1.62087913
47MP0002735_abnormal_chemical_nociception1.60080972
48MP0002419_abnormal_innate_immunity1.57815826
49MP0002722_abnormal_immune_system1.57157031
50MP0000689_abnormal_spleen_morphology1.56983468
51MP0002405_respiratory_system_inflammati1.56529903
52MP0000703_abnormal_thymus_morphology1.56059098
53MP0000716_abnormal_immune_system1.54340440
54MP0003941_abnormal_skin_development1.51651028
55MP0005387_immune_system_phenotype1.50885952
56MP0001790_abnormal_immune_system1.50885952
57MP0009745_abnormal_behavioral_response1.49924510
58MP0002429_abnormal_blood_cell1.49686623
59MP0000015_abnormal_ear_pigmentation1.49335555
60MP0002249_abnormal_larynx_morphology1.48264668
61MP0009278_abnormal_bone_marrow1.41366391
62MP0010307_abnormal_tumor_latency1.40790228
63MP0000350_abnormal_cell_proliferation1.38094432
64MP0002277_abnormal_respiratory_mucosa1.37995255
65MP0001905_abnormal_dopamine_level1.37704523
66MP0004142_abnormal_muscle_tone1.37004228
67MP0003635_abnormal_synaptic_transmissio1.36916323
68MP0005409_darkened_coat_color1.36838464
69MP0006292_abnormal_olfactory_placode1.36555421
70MP0001970_abnormal_pain_threshold1.33993901
71MP0004859_abnormal_synaptic_plasticity1.32594062
72MP0000313_abnormal_cell_death1.31524558
73MP0002064_seizures1.30984486
74MP0001853_heart_inflammation1.29300047
75MP0004381_abnormal_hair_follicle1.29201089
76MP0002063_abnormal_learning/memory/cond1.27012381
77MP0003656_abnormal_erythrocyte_physiolo1.26016565
78MP0008877_abnormal_DNA_methylation1.25988970
79MP0003315_abnormal_perineum_morphology1.23984852
80MP0002019_abnormal_tumor_incidence1.21887499
81MP0001529_abnormal_vocalization1.21019314
82MP0002160_abnormal_reproductive_system1.19749710
83MP0005464_abnormal_platelet_physiology1.19674240
84MP0005084_abnormal_gallbladder_morpholo1.19209911
85MP0002272_abnormal_nervous_system1.18346025
86MP0002572_abnormal_emotion/affect_behav1.17894336
87MP0010030_abnormal_orbit_morphology1.17018838
88MP0002928_abnormal_bile_duct1.13248612
89MP0001664_abnormal_digestion1.12313169
90MP0005075_abnormal_melanosome_morpholog1.11178184
91MP0002822_catalepsy1.10719256
92MP0002163_abnormal_gland_morphology1.09966068
93MP0003123_paternal_imprinting1.09122934
94MP0008961_abnormal_basal_metabolism1.07816138
95MP0005076_abnormal_cell_differentiation1.05658055
96MP0003448_altered_tumor_morphology1.04805023
97MP0002736_abnormal_nociception_after1.04591316
98MP0002751_abnormal_autonomic_nervous1.03888027
99MP0010155_abnormal_intestine_physiology1.03269715
100MP0001188_hyperpigmentation1.03192719
101MP0001730_embryonic_growth_arrest1.02977959
102MP0005174_abnormal_tail_pigmentation1.00397658
103MP0002067_abnormal_sensory_capabilities1.00041527
104MP0010352_gastrointestinal_tract_polyps0.99356462
105MP0003329_amyloid_beta_deposits0.99062635
106MP0008260_abnormal_autophagy0.97925309
107MP0009046_muscle_twitch0.97199979
108MP0001845_abnormal_inflammatory_respons0.96938963
109MP0005389_reproductive_system_phenotype0.94790887
110MP0008789_abnormal_olfactory_epithelium0.92971676
111MP0004947_skin_inflammation0.92226388
112MP0003172_abnormal_lysosome_physiology0.91456115
113MP0006054_spinal_hemorrhage0.90804352
114MP0002095_abnormal_skin_pigmentation0.90658280
115MP0000955_abnormal_spinal_cord0.90487520
116MP0001486_abnormal_startle_reflex0.90016182
117MP0003724_increased_susceptibility_to0.89940655
118MP0004510_myositis0.89308025
119MP0003705_abnormal_hypodermis_morpholog0.88264872
120MP0002557_abnormal_social/conspecific_i0.86372038
121MP0003186_abnormal_redox_activity0.85728720
122MP0000049_abnormal_middle_ear0.85651920
123MP0002080_prenatal_lethality0.85174957
124MP0004130_abnormal_muscle_cell0.84651811
125MP0002075_abnormal_coat/hair_pigmentati0.83905268
126MP0004858_abnormal_nervous_system0.83392882
127MP0001958_emphysema0.83027594
128MP0000371_diluted_coat_color0.82629192
129MP0003718_maternal_effect0.82538552
130MP0000681_abnormal_thyroid_gland0.80644690
131MP0005621_abnormal_cell_physiology0.79807338
132MP0001873_stomach_inflammation0.79773750
133MP0002882_abnormal_neuron_morphology0.77542027
134MP0003303_peritoneal_inflammation0.77258825
135MP0001663_abnormal_digestive_system0.77172237
136MP0005499_abnormal_olfactory_system0.77034831
137MP0005394_taste/olfaction_phenotype0.77034831
138MP0001533_abnormal_skeleton_physiology0.77004419
139MP0006082_CNS_inflammation0.75975138
140MP0005310_abnormal_salivary_gland0.75965304
141MP0002152_abnormal_brain_morphology0.75687219
142MP0001293_anophthalmia0.75656352
143MP0004782_abnormal_surfactant_physiolog0.75424733
144MP0004133_heterotaxia0.74315854
145MP0005551_abnormal_eye_electrophysiolog0.74063344
146MP0004811_abnormal_neuron_physiology0.73952143
147MP0003453_abnormal_keratinocyte_physiol0.73807672
148MP0000026_abnormal_inner_ear0.73689716
149MP0005384_cellular_phenotype0.73183578
150MP0001697_abnormal_embryo_size0.72766538
151MP0003137_abnormal_impulse_conducting0.72240273
152MP0001672_abnormal_embryogenesis/_devel0.71731791
153MP0005380_embryogenesis_phenotype0.71731791
154MP0001944_abnormal_pancreas_morphology0.71230635
155MP0000678_abnormal_parathyroid_gland0.71032601
156MP0003136_yellow_coat_color0.70296514
157MP0000465_gastrointestinal_hemorrhage0.70265167
158MP0005386_behavior/neurological_phenoty0.70190342
159MP0004924_abnormal_behavior0.70190342
160MP0003866_abnormal_defecation0.69241888
161MP0001186_pigmentation_phenotype0.69202109
162MP0002234_abnormal_pharynx_morphology0.68946864
163MP0000631_abnormal_neuroendocrine_gland0.68708931
164MP0000470_abnormal_stomach_morphology0.68633898
165MP0003879_abnormal_hair_cell0.68159224
166MP0001346_abnormal_lacrimal_gland0.67469792
167MP0002752_abnormal_somatic_nervous0.67175258
168MP0005379_endocrine/exocrine_gland_phen0.66816629
169MP0002733_abnormal_thermal_nociception0.66432156
170MP0001756_abnormal_urination0.66431460
171MP0001119_abnormal_female_reproductive0.66318791
172MP0005377_hearing/vestibular/ear_phenot0.65398768
173MP0003878_abnormal_ear_physiology0.65398768
174MP0003880_abnormal_central_pattern0.65199950
175MP0002734_abnormal_mechanical_nocicepti0.61625516
176MP0006276_abnormal_autonomic_nervous0.61414911
177MP0003119_abnormal_digestive_system0.61260440
178MP0003959_abnormal_lean_body0.60771050
179MP0002184_abnormal_innervation0.59916311
180MP0003861_abnormal_nervous_system0.59766684
181MP0003942_abnormal_urinary_system0.59473174
182MP0004043_abnormal_pH_regulation0.59084027
183MP0003806_abnormal_nucleotide_metabolis0.58810566
184MP0000003_abnormal_adipose_tissue0.57124730

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.36653108
2Birth length less than 3rd percentile (HP:0003561)5.08373243
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.65992329
4Hypoplasia of the pons (HP:0012110)4.65944151
5Abnormality of the pons (HP:0007361)4.41611162
6Chromsome breakage (HP:0040012)4.30023870
7Testicular atrophy (HP:0000029)4.27423257
8Annular pancreas (HP:0001734)4.13971095
9Congenital stationary night blindness (HP:0007642)3.99180882
10Type II lissencephaly (HP:0007260)3.50900573
11Reticulocytopenia (HP:0001896)3.41880821
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.41879252
13Degeneration of anterior horn cells (HP:0002398)3.27589135
14Abnormality of the anterior horn cell (HP:0006802)3.27589135
15Squamous cell carcinoma (HP:0002860)3.25850214
16Rectovaginal fistula (HP:0000143)3.16285182
17Rectal fistula (HP:0100590)3.16285182
18Ulnar bowing (HP:0003031)3.15826005
19Abnormal number of erythroid precursors (HP:0012131)3.15180281
20Intestinal fistula (HP:0100819)3.04577935
21Breast hypoplasia (HP:0003187)2.99555445
22Rough bone trabeculation (HP:0100670)2.95361167
23Abnormality of cells of the erythroid lineage (HP:0012130)2.95152624
24Amblyopia (HP:0000646)2.92691614
25Cerebellar dysplasia (HP:0007033)2.92287980
26Recurrent abscess formation (HP:0002722)2.91855519
27Duplicated collecting system (HP:0000081)2.88996864
28Agnosia (HP:0010524)2.88724476
29Chorioretinal atrophy (HP:0000533)2.87438495
30Aplastic anemia (HP:0001915)2.86686568
31Abnormal drinking behavior (HP:0030082)2.86215320
32Polydipsia (HP:0001959)2.86215320
33Broad distal phalanx of finger (HP:0009836)2.85205525
34Patellar aplasia (HP:0006443)2.82972342
35Poikiloderma (HP:0001029)2.78559033
36Abnormality of the renal collecting system (HP:0004742)2.77429539
37Vaginal fistula (HP:0004320)2.75047716
38Abnormality of the preputium (HP:0100587)2.74546948
39Turricephaly (HP:0000262)2.72344626
40Severe muscular hypotonia (HP:0006829)2.69350715
41Meckel diverticulum (HP:0002245)2.68210130
42Facial hemangioma (HP:0000329)2.67914688
43Mediastinal lymphadenopathy (HP:0100721)2.67796967
44Elevated erythrocyte sedimentation rate (HP:0003565)2.66373872
45Thin bony cortex (HP:0002753)2.65948667
46Renal Fanconi syndrome (HP:0001994)2.65689964
47Bone marrow hypocellularity (HP:0005528)2.65534105
48Coronal craniosynostosis (HP:0004440)2.61541246
49Pendular nystagmus (HP:0012043)2.61343184
50Attenuation of retinal blood vessels (HP:0007843)2.57964093
51Abnormality of the ileum (HP:0001549)2.57236860
52Premature graying of hair (HP:0002216)2.57186138
53Concave nail (HP:0001598)2.55932727
54Type I transferrin isoform profile (HP:0003642)2.55756048
55Aplasia/Hypoplasia of the patella (HP:0006498)2.54373967
56Eczematoid dermatitis (HP:0000976)2.53184016
57Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.49396343
58IgM deficiency (HP:0002850)2.48602228
59Bony spicule pigmentary retinopathy (HP:0007737)2.48244663
60Petechiae (HP:0000967)2.47089538
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.46007861
62Bowing of the arm (HP:0006488)2.45595541
63Bowed forearm bones (HP:0003956)2.45595541
64Ulnar claw (HP:0001178)2.43225275
65Oral leukoplakia (HP:0002745)2.43121837
66Joint stiffness (HP:0001387)2.42267759
67Epileptic encephalopathy (HP:0200134)2.42059080
68Gastrointestinal infarctions (HP:0005244)2.41580433
69Thrombocytosis (HP:0001894)2.41488457
70Cheilitis (HP:0100825)2.37857028
71Recurrent bacterial skin infections (HP:0005406)2.37630542
72Short chin (HP:0000331)2.35680114
73Prostate neoplasm (HP:0100787)2.33523926
74Retinal dysplasia (HP:0007973)2.31429536
75Akinesia (HP:0002304)2.31027262
76Tubular atrophy (HP:0000092)2.30639994
77Increased hepatocellular lipid droplets (HP:0006565)2.30017744
78Clubbing of toes (HP:0100760)2.28832995
79Cleft eyelid (HP:0000625)2.28115479
80Recurrent fungal infections (HP:0002841)2.27315440
8111 pairs of ribs (HP:0000878)2.26277825
82Cerebral hypomyelination (HP:0006808)2.26163890
83Abnormal trabecular bone morphology (HP:0100671)2.25811901
84Hypoplasia of the radius (HP:0002984)2.25141271
85Type 2 muscle fiber atrophy (HP:0003554)2.24835672
86Absent thumb (HP:0009777)2.24682531
87Pallor (HP:0000980)2.23582094
88Myelodysplasia (HP:0002863)2.22134542
89Aplasia of the musculature (HP:0100854)2.21554870
90Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20691358
91Slender long bone (HP:0003100)2.19658748
92Anterior segment dysgenesis (HP:0007700)2.18570596
93Abnormality of chromosome stability (HP:0003220)2.17814594
94Short thumb (HP:0009778)2.17405717
95Non-midline cleft lip (HP:0100335)2.17170669
96Cellular immunodeficiency (HP:0005374)2.15768737
97Selective tooth agenesis (HP:0001592)2.14024717
98Abnormality of the heme biosynthetic pathway (HP:0010472)2.10706339
99Nephronophthisis (HP:0000090)2.08569229
100IgG deficiency (HP:0004315)2.08359108
101Abnormal protein glycosylation (HP:0012346)2.08108244
102Abnormal glycosylation (HP:0012345)2.08108244
103Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08108244
104Abnormal protein N-linked glycosylation (HP:0012347)2.08108244
105Lymphoma (HP:0002665)2.07156791
106Lipid accumulation in hepatocytes (HP:0006561)2.06843714
107Microvesicular hepatic steatosis (HP:0001414)2.06271918
108Recurrent viral infections (HP:0004429)2.06190157
109Hypoplastic nipples (HP:0002557)2.04614251
110Duodenal stenosis (HP:0100867)2.04460527
111Small intestinal stenosis (HP:0012848)2.04460527
112Spinal cord lesions (HP:0100561)2.02571335
113Syringomyelia (HP:0003396)2.02571335
114Myositis (HP:0100614)2.02120964
115Abnormality of alanine metabolism (HP:0010916)2.01925305
116Hyperalaninemia (HP:0003348)2.01925305
117Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01925305
118Stomatitis (HP:0010280)1.99539596
119Muscle fiber atrophy (HP:0100295)1.99399696
120Mesangial abnormality (HP:0001966)1.99072722
121Molar tooth sign on MRI (HP:0002419)1.97498929
122Abnormality of midbrain morphology (HP:0002418)1.97498929
123Fetal akinesia sequence (HP:0001989)1.97230198
124Tracheoesophageal fistula (HP:0002575)1.96948134
125Absent radius (HP:0003974)1.95633098
126Abnormality of DNA repair (HP:0003254)1.95587948
127Ectopic kidney (HP:0000086)1.95187057
128Poor head control (HP:0002421)1.94816488
129Carpal bone hypoplasia (HP:0001498)1.93169531
130Atrophy/Degeneration involving motor neurons (HP:0007373)1.92051450
131Pustule (HP:0200039)1.90644995
132Spinal muscular atrophy (HP:0007269)1.90278316
133Chronic otitis media (HP:0000389)1.90070628
134Optic neuritis (HP:0100653)1.88876088
135Retrobulbar optic neuritis (HP:0100654)1.88876088
136Microretrognathia (HP:0000308)1.87758383
137Spina bifida occulta (HP:0003298)1.87577542
138Decreased circulating renin level (HP:0003351)1.87424884
139Lissencephaly (HP:0001339)1.87358526
140Pancytopenia (HP:0001876)1.87222512
141Pulmonary fibrosis (HP:0002206)1.85146933
142Hypoplasia of the capital femoral epiphysis (HP:0003090)1.85120217
143Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84415277
144Granulocytopenia (HP:0001913)1.83891751
145Cortical visual impairment (HP:0100704)1.83118242
146Polyuria (HP:0000103)1.82654323
147Absent forearm bone (HP:0003953)1.80620488
148Aplasia involving forearm bones (HP:0009822)1.80620488
1493-Methylglutaconic aciduria (HP:0003535)1.80588584
150Triphalangeal thumb (HP:0001199)1.79791127
151Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78608117
152Hypochromic anemia (HP:0001931)1.78512139
153Trismus (HP:0000211)1.78507676
154Macrocytic anemia (HP:0001972)1.77126997
155Recurrent cutaneous fungal infections (HP:0011370)1.76073520
156Chronic mucocutaneous candidiasis (HP:0002728)1.76073520
157Increased intramyocellular lipid droplets (HP:0012240)1.75582745
158Hyperacusis (HP:0010780)1.75505704
159Ureteral duplication (HP:0000073)1.75229186
160Delayed epiphyseal ossification (HP:0002663)1.75109511
161Obstructive lung disease (HP:0006536)1.74268672
162Chronic obstructive pulmonary disease (HP:0006510)1.74268672
163Abnormality of T cells (HP:0002843)1.73150300
164Flat occiput (HP:0005469)1.72967639
165Optic nerve coloboma (HP:0000588)1.71886981
166Mitochondrial inheritance (HP:0001427)1.71695888
167Abnormal hair whorl (HP:0010721)1.71516633
168Progressive microcephaly (HP:0000253)1.71489955
169Abnormality of T cell physiology (HP:0011840)1.70715103
170Aplasia/Hypoplasia of the spleen (HP:0010451)1.70097743
171Gingivitis (HP:0000230)1.69334532
172Capillary hemangiomas (HP:0005306)1.69314919
173Asplenia (HP:0001746)1.68516978
174Rectal prolapse (HP:0002035)1.63804173
175Flat capital femoral epiphysis (HP:0003370)1.63344973
176Narrow nasal bridge (HP:0000446)1.62910752
177Meningocele (HP:0002435)1.61979127
178Arthropathy (HP:0003040)1.61792031
179Increased muscle lipid content (HP:0009058)1.61177362
180Respiratory difficulties (HP:0002880)1.59522439
181Abnormality of the costochondral junction (HP:0000919)1.55993079
182Aplasia/Hypoplasia involving the musculature (HP:0001460)1.55816018
183Abnormal number of incisors (HP:0011064)1.55210549

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.79917104
2BUB13.59398595
3EIF2AK13.25050582
4IRAK33.01373654
5ADRBK22.73270977
6NME22.69737884
7TSSK62.54110724
8IRAK42.50989538
9EPHA22.50740915
10SIK32.29192515
11MAP3K92.27545384
12PNCK2.25153287
13MAP4K12.10672761
14VRK12.09906289
15PLK42.02735043
16TRIB32.02690581
17SIK22.01813463
18TAOK11.99601502
19PIM21.97615692
20WEE11.94960702
21JAK31.92998983
22RPS6KA41.92793813
23WNK41.90794400
24SIK11.90417171
25EIF2AK31.89347429
26ZAK1.81207392
27BRSK21.78077784
28TXK1.76666498
29TESK21.74737849
30MAP3K141.70103834
31GRK71.68900560
32SRPK11.67297755
33STK161.64417259
34TLK11.57642530
35AKT31.56428616
36CAMK1D1.55822227
37GRK61.50408864
38BRAF1.49863796
39STK101.47698023
40ICK1.46869565
41SMG11.44714986
42PRKD21.40967566
43MAP3K111.37868197
44BRSK11.37321768
45TYK21.35272449
46CCNB11.34271322
47ATR1.33933976
48DYRK1B1.33891965
49CDC71.30091866
50BMPR1B1.28376599
51DYRK31.28364900
52PINK11.23897719
53MARK31.22727367
54IKBKB1.22568395
55PLK31.22085458
56PLK11.16676856
57MAPKAPK31.11983360
58KSR21.11698676
59TAOK21.11318653
60CLK11.10026824
61MAP2K71.05342330
62ADRBK11.04188263
63EPHB21.03978376
64KIT1.03402128
65YES11.03166265
66ABL21.02762915
67PASK1.02576257
68EIF2AK21.02495314
69BTK1.02279620
70MAP3K81.02129709
71PIM11.02115432
72CAMKK11.01105258
73MAPK131.00246631
74STK110.99953969
75KSR10.99591158
76TTK0.97046943
77DAPK20.96760269
78TYRO30.96651737
79RPS6KB20.95793570
80BRD40.95580404
81BLK0.94536376
82PRPF4B0.93554278
83ZAP700.93500136
84PAK60.93483830
85CAMK1G0.92577549
86CAMKK20.92079064
87IKBKE0.90328945
88TESK10.90108521
89NTRK30.89681330
90MAP2K20.86575867
91MAPK120.84891569
92MKNK20.83682606
93CDK70.82942843
94AURKB0.82762864
95IRAK20.79925591
96TGFBR10.78879940
97MARK10.77611575
98CHUK0.77190823
99AURKA0.76929294
100RPS6KA50.76892087
101CHEK20.76591207
102MKNK10.76490848
103PDPK10.75593058
104CDK80.75571813
105TEC0.75556184
106EPHB10.75265031
107SYK0.74927085
108RIPK40.74208669
109RAF10.73779759
110MAP2K40.73562839
111FLT30.73393158
112NEK20.72133165
113TBK10.71834945
114MAP2K60.71588223
115ARAF0.70041151
116STK40.69374326
117KDR0.68659863
118MARK20.65951611
119CHEK10.64708604
120CAMK40.61253060
121EEF2K0.58955818
122PRKCI0.57374786
123NTRK20.57173402
124PAK10.57066190
125HIPK20.56553823
126MAP3K100.56371222
127TNK20.55271435
128EPHA40.55063296
129MAP2K30.53898303
130RPS6KA60.53878204
131LYN0.53736114
132RPS6KC10.53142452
133RPS6KL10.53142452
134LRRK20.51478224
135MAPK110.51268399
136ERN10.50815132
137MAPKAPK20.50790852
138RPS6KA10.49895910
139STK38L0.49548253
140MAP3K30.48829969
141DAPK10.48541456
142CAMK10.46669071
143DYRK20.45957691
144MAP3K120.44598088
145CDK40.44158962
146UHMK10.44033932
147LCK0.43863227
148MTOR0.43733860
149MST40.43551082
150CSNK2A10.43470642
151PRKCZ0.42706563
152ATM0.42536325
153PAK40.42096553
154GRK10.41927570
155PRKCG0.41381577
156MUSK0.41303180
157CDK20.40550191
158MOS0.39154760
159CDK30.38945423
160RPS6KA20.38628520
161BMX0.38344333
162CDK11A0.37571031
163BCKDK0.37114389
164PRKCD0.36820342
165DAPK30.35572591

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006044.91188921
2DNA replication_Homo sapiens_hsa030303.90743301
3Mismatch repair_Homo sapiens_hsa034303.10599232
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.05514886
5RNA polymerase_Homo sapiens_hsa030203.01588086
6Proteasome_Homo sapiens_hsa030502.98605235
7Ribosome_Homo sapiens_hsa030102.65056427
8Spliceosome_Homo sapiens_hsa030402.50688763
9Base excision repair_Homo sapiens_hsa034102.49768632
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.40593238
11Oxidative phosphorylation_Homo sapiens_hsa001902.36776106
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.28351994
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21711642
14Homologous recombination_Homo sapiens_hsa034402.20987600
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.12543793
16Nucleotide excision repair_Homo sapiens_hsa034202.10849474
17Parkinsons disease_Homo sapiens_hsa050122.08221414
18Pyrimidine metabolism_Homo sapiens_hsa002402.07037502
19Fanconi anemia pathway_Homo sapiens_hsa034601.98375194
20RNA transport_Homo sapiens_hsa030131.96357882
21Cell cycle_Homo sapiens_hsa041101.89787295
22One carbon pool by folate_Homo sapiens_hsa006701.82131431
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.65403289
24Basal transcription factors_Homo sapiens_hsa030221.62322997
25p53 signaling pathway_Homo sapiens_hsa041151.54025604
26Primary immunodeficiency_Homo sapiens_hsa053401.50296507
27Non-homologous end-joining_Homo sapiens_hsa034501.44534044
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43458853
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.42469873
30RNA degradation_Homo sapiens_hsa030181.39805430
31Epstein-Barr virus infection_Homo sapiens_hsa051691.39034338
32Bladder cancer_Homo sapiens_hsa052191.36498859
33Herpes simplex infection_Homo sapiens_hsa051681.35046437
34Cardiac muscle contraction_Homo sapiens_hsa042601.34239400
35Nicotine addiction_Homo sapiens_hsa050331.31905277
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.29419517
37Measles_Homo sapiens_hsa051621.28686129
38Fructose and mannose metabolism_Homo sapiens_hsa000511.28506937
39Legionellosis_Homo sapiens_hsa051341.27262232
40Alzheimers disease_Homo sapiens_hsa050101.25227197
41Antigen processing and presentation_Homo sapiens_hsa046121.19167905
42Synaptic vesicle cycle_Homo sapiens_hsa047211.15073853
43Purine metabolism_Homo sapiens_hsa002301.13530263
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12038187
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.11757707
46Sulfur relay system_Homo sapiens_hsa041221.10830051
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.06306530
48Leishmaniasis_Homo sapiens_hsa051401.04142668
49Allograft rejection_Homo sapiens_hsa053301.04123016
50VEGF signaling pathway_Homo sapiens_hsa043701.03783524
51Influenza A_Homo sapiens_hsa051641.02538512
52mRNA surveillance pathway_Homo sapiens_hsa030151.01959954
53Taste transduction_Homo sapiens_hsa047421.00257776
54Axon guidance_Homo sapiens_hsa043601.00153341
55Morphine addiction_Homo sapiens_hsa050321.00086167
56Protein export_Homo sapiens_hsa030600.99644305
57Shigellosis_Homo sapiens_hsa051310.99415909
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98750314
59Graft-versus-host disease_Homo sapiens_hsa053320.95798730
60Apoptosis_Homo sapiens_hsa042100.95660050
61Cocaine addiction_Homo sapiens_hsa050300.94813641
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94605832
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93874520
64Other glycan degradation_Homo sapiens_hsa005110.92228209
65Hedgehog signaling pathway_Homo sapiens_hsa043400.91562285
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88483740
67Viral carcinogenesis_Homo sapiens_hsa052030.87633105
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87225082
69HTLV-I infection_Homo sapiens_hsa051660.86853202
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85233629
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85124969
72Hematopoietic cell lineage_Homo sapiens_hsa046400.83772571
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82309379
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82060145
75Ovarian steroidogenesis_Homo sapiens_hsa049130.81929298
76MAPK signaling pathway_Homo sapiens_hsa040100.81089903
77Hepatitis B_Homo sapiens_hsa051610.79650684
78Cholinergic synapse_Homo sapiens_hsa047250.77427788
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77119920
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75953247
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75307637
82Basal cell carcinoma_Homo sapiens_hsa052170.74941047
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71456397
84Rheumatoid arthritis_Homo sapiens_hsa053230.71060053
85Tuberculosis_Homo sapiens_hsa051520.69283091
86Systemic lupus erythematosus_Homo sapiens_hsa053220.67595266
87Phagosome_Homo sapiens_hsa041450.67180348
88Pertussis_Homo sapiens_hsa051330.65942575
89Hippo signaling pathway_Homo sapiens_hsa043900.65903522
90Calcium signaling pathway_Homo sapiens_hsa040200.65674007
91Osteoclast differentiation_Homo sapiens_hsa043800.65393169
92Phototransduction_Homo sapiens_hsa047440.64672240
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63304974
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62591721
95Type I diabetes mellitus_Homo sapiens_hsa049400.62258192
96Asthma_Homo sapiens_hsa053100.62180923
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61418316
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61033739
99Glutamatergic synapse_Homo sapiens_hsa047240.58967284
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58419215
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.58218546
102Autoimmune thyroid disease_Homo sapiens_hsa053200.58106903
103GABAergic synapse_Homo sapiens_hsa047270.57543844
104Insulin secretion_Homo sapiens_hsa049110.57372266
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55153000
106TNF signaling pathway_Homo sapiens_hsa046680.54915684
107Alcoholism_Homo sapiens_hsa050340.53090039
108Salmonella infection_Homo sapiens_hsa051320.52532078
109Melanogenesis_Homo sapiens_hsa049160.50594203
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48938818
111Viral myocarditis_Homo sapiens_hsa054160.48085804
112Folate biosynthesis_Homo sapiens_hsa007900.47537922
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46564607
114Regulation of autophagy_Homo sapiens_hsa041400.45214004
115N-Glycan biosynthesis_Homo sapiens_hsa005100.44002698
116Toxoplasmosis_Homo sapiens_hsa051450.43980271
117Notch signaling pathway_Homo sapiens_hsa043300.43790533
118T cell receptor signaling pathway_Homo sapiens_hsa046600.43283987
119ErbB signaling pathway_Homo sapiens_hsa040120.43101404
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43043076
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42806881
122Malaria_Homo sapiens_hsa051440.42688168
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.41443703
124Pentose phosphate pathway_Homo sapiens_hsa000300.40528667
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39979285
126GnRH signaling pathway_Homo sapiens_hsa049120.39581448
127Lysosome_Homo sapiens_hsa041420.39097339
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39063713
129B cell receptor signaling pathway_Homo sapiens_hsa046620.38823524
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38592684
131Huntingtons disease_Homo sapiens_hsa050160.38376458
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38372261
133Estrogen signaling pathway_Homo sapiens_hsa049150.38191744
134Oocyte meiosis_Homo sapiens_hsa041140.37971667
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.37659672
136Acute myeloid leukemia_Homo sapiens_hsa052210.37535884
137Prion diseases_Homo sapiens_hsa050200.37174174
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36733307
139Gap junction_Homo sapiens_hsa045400.36590084
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36309772
141Hepatitis C_Homo sapiens_hsa051600.35669478
142Maturity onset diabetes of the young_Homo sapiens_hsa049500.35510238
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35436979
144Chronic myeloid leukemia_Homo sapiens_hsa052200.34139766
145Dopaminergic synapse_Homo sapiens_hsa047280.33312040
146Collecting duct acid secretion_Homo sapiens_hsa049660.33185307
147Renal cell carcinoma_Homo sapiens_hsa052110.32944111
148Endocytosis_Homo sapiens_hsa041440.32584573
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31383193
150Sphingolipid metabolism_Homo sapiens_hsa006000.31034062
151FoxO signaling pathway_Homo sapiens_hsa040680.30781199
152Chemokine signaling pathway_Homo sapiens_hsa040620.30570909
153Melanoma_Homo sapiens_hsa052180.30537951
154Prolactin signaling pathway_Homo sapiens_hsa049170.30441686
155Vibrio cholerae infection_Homo sapiens_hsa051100.29723807
156Inositol phosphate metabolism_Homo sapiens_hsa005620.27591406
157Small cell lung cancer_Homo sapiens_hsa052220.27528337
158cAMP signaling pathway_Homo sapiens_hsa040240.27424394
159Dorso-ventral axis formation_Homo sapiens_hsa043200.26456701
160Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25973881
161Circadian rhythm_Homo sapiens_hsa047100.25393270
162Oxytocin signaling pathway_Homo sapiens_hsa049210.25195333
163Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25177020
164Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25121372
165HIF-1 signaling pathway_Homo sapiens_hsa040660.24013954

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