ASB7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K36 demethylation (GO:0070544)5.73929923
2presynaptic membrane assembly (GO:0097105)5.52389957
3nuclear pore complex assembly (GO:0051292)5.22195574
4presynaptic membrane organization (GO:0097090)4.89394919
5histone H3-K4 trimethylation (GO:0080182)4.28766885
6neural tube formation (GO:0001841)4.28563915
7nuclear pore organization (GO:0006999)4.28484475
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.26989426
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.26989426
10modulation by symbiont of host immune response (GO:0052553)4.26989426
11positive regulation by symbiont of host defense response (GO:0052509)4.26989426
12modulation by symbiont of host defense response (GO:0052031)4.26989426
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.26989426
14positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.87576141
15pore complex assembly (GO:0046931)3.86010586
16cerebral cortex radially oriented cell migration (GO:0021799)3.83746538
17regulation of interferon-beta biosynthetic process (GO:0045357)3.83611381
18positive regulation of gamma-delta T cell activation (GO:0046645)3.82322368
19cytoplasmic mRNA processing body assembly (GO:0033962)3.81774442
20interkinetic nuclear migration (GO:0022027)3.78984066
21negative regulation of neurotransmitter secretion (GO:0046929)3.76600338
22response to peptidoglycan (GO:0032494)3.64091338
23protein localization to Golgi apparatus (GO:0034067)3.63188652
24mitotic sister chromatid cohesion (GO:0007064)3.58281126
25embryonic process involved in female pregnancy (GO:0060136)3.57504964
26embryonic camera-type eye morphogenesis (GO:0048596)3.53269262
27dosage compensation (GO:0007549)3.49278309
28positive regulation of histone H3-K4 methylation (GO:0051571)3.47847126
29response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.41623906
30response to host immune response (GO:0052572)3.41623906
31asymmetric protein localization (GO:0008105)3.39365104
32regulation of DNA endoreduplication (GO:0032875)3.38782625
33central nervous system myelination (GO:0022010)3.36597339
34axon ensheathment in central nervous system (GO:0032291)3.36597339
35response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.32582367
36response to host (GO:0075136)3.32582367
37response to host defenses (GO:0052200)3.32582367
38antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.29214243
39negative regulation of neurotransmitter transport (GO:0051589)3.27288038
40photoreceptor cell differentiation (GO:0046530)3.25779806
41eye photoreceptor cell differentiation (GO:0001754)3.25779806
42detection of other organism (GO:0098543)3.22323781
43olfactory bulb development (GO:0021772)3.21655669
44cellular extravasation (GO:0045123)3.17544046
45histone lysine demethylation (GO:0070076)3.17235248
46ER overload response (GO:0006983)3.16878775
47germinal center formation (GO:0002467)3.15322010
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.14119662
49negative regulation of oligodendrocyte differentiation (GO:0048715)3.13727750
50detection of molecule of bacterial origin (GO:0032490)3.13662767
51macrophage activation involved in immune response (GO:0002281)3.13484667
52production of molecular mediator involved in inflammatory response (GO:0002532)3.11841755
53negative regulation of stem cell proliferation (GO:2000647)3.09642860
54response to laminar fluid shear stress (GO:0034616)3.08681812
55positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.07858851
56regulation of B cell receptor signaling pathway (GO:0050855)3.06618195
57regulation of oligodendrocyte differentiation (GO:0048713)3.05124380
58hepatocyte apoptotic process (GO:0097284)3.05023389
59B cell receptor signaling pathway (GO:0050853)3.01762667
60antigen processing and presentation of endogenous antigen (GO:0019883)3.00880807
61negative regulation of myoblast differentiation (GO:0045662)2.99766369
62granulocyte differentiation (GO:0030851)2.98382728
63germ cell migration (GO:0008354)2.98110537
64regulation of histone H3-K4 methylation (GO:0051569)2.90764412
65B cell homeostasis (GO:0001782)2.88030600
66neuron cell-cell adhesion (GO:0007158)2.87368377
67response to muramyl dipeptide (GO:0032495)2.86677354
68mannosylation (GO:0097502)2.86362299
69response to interleukin-15 (GO:0070672)2.85557969
70regulation of T-helper 2 cell differentiation (GO:0045628)2.85224550
71regulation of gamma-delta T cell activation (GO:0046643)2.84471778
723-UTR-mediated mRNA stabilization (GO:0070935)2.84246751
73histone demethylation (GO:0016577)2.83700666
74detection of bacterium (GO:0016045)2.82910380
75neutrophil activation involved in immune response (GO:0002283)2.80421219
76detection of external biotic stimulus (GO:0098581)2.79741381
77negative regulation of erythrocyte differentiation (GO:0045647)2.78705826
78histone H3-K9 demethylation (GO:0033169)2.77894835
79cerebral cortex cell migration (GO:0021795)2.77530498
80positive regulation of oligodendrocyte differentiation (GO:0048714)2.77270607
81central nervous system projection neuron axonogenesis (GO:0021952)2.76208078
82regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.76113674
83negative regulation of interleukin-12 production (GO:0032695)2.75292422
84positive regulation of interferon-alpha production (GO:0032727)2.73714749
85protein localization to endosome (GO:0036010)2.72325338
86negative regulation of cell killing (GO:0031342)2.72321352
87negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.72321352
88intraciliary transport (GO:0042073)2.72075248
89apical protein localization (GO:0045176)2.71018920
90negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.70187588
91limb bud formation (GO:0060174)2.70079982
92negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.69080948
93negative regulation of translation, ncRNA-mediated (GO:0040033)2.69080948
94regulation of translation, ncRNA-mediated (GO:0045974)2.69080948
95antigen processing and presentation via MHC class Ib (GO:0002475)2.69077305
96leukocyte aggregation (GO:0070486)2.68294045
97neutrophil mediated immunity (GO:0002446)2.68153398
98cranial nerve morphogenesis (GO:0021602)2.66645582
99myeloid leukocyte mediated immunity (GO:0002444)2.66486880
100peptidyl-lysine trimethylation (GO:0018023)2.65448624
101megakaryocyte development (GO:0035855)2.65309671
102positive regulation of interferon-beta production (GO:0032728)2.64098116
103alternative mRNA splicing, via spliceosome (GO:0000380)2.62541247
104regulation of RNA export from nucleus (GO:0046831)2.62087828
105DNA integration (GO:0015074)2.60880326
106positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.60155592
107spliceosomal tri-snRNP complex assembly (GO:0000244)2.59103360
108negative regulation of glycogen biosynthetic process (GO:0045719)2.58999349
109COPII vesicle coating (GO:0048208)2.58639345
110retina layer formation (GO:0010842)2.58618884
111embryonic retina morphogenesis in camera-type eye (GO:0060059)2.58492454
112negative regulation of T-helper cell differentiation (GO:0045623)2.56312735
113negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.56312735
114antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.55993691
115positive regulation of granulocyte differentiation (GO:0030854)2.55354070
116regulation of gamma-delta T cell differentiation (GO:0045586)2.55169244
117regulation of protein polyubiquitination (GO:1902914)2.52006991
118positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.51366540
119dentate gyrus development (GO:0021542)2.50789551
120developmental pigmentation (GO:0048066)2.50140621
121protein localization to microtubule cytoskeleton (GO:0072698)2.50075671
122positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.49355391
123CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.49281755
124T-helper cell differentiation (GO:0042093)2.49281755
125regulation of type I interferon-mediated signaling pathway (GO:0060338)2.48795088
126anatomical structure arrangement (GO:0048532)2.48529983
127T cell migration (GO:0072678)2.48357955
128regulation of histone H3-K9 methylation (GO:0051570)2.47287854
129substrate-independent telencephalic tangential migration (GO:0021826)2.47145475
130substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.47145475
131regulation of interferon-alpha production (GO:0032647)2.47066233
132neutrophil activation (GO:0042119)2.45980941
133sympathetic nervous system development (GO:0048485)2.43669072
134central nervous system neuron axonogenesis (GO:0021955)2.43075951
135granulocyte activation (GO:0036230)2.42950672
136positive regulation by host of viral transcription (GO:0043923)2.42268093
137prostate gland growth (GO:0060736)2.41765298
138stress granule assembly (GO:0034063)2.41592673
139ether lipid metabolic process (GO:0046485)2.40222094
140B cell proliferation (GO:0042100)2.40062914
141regulation of histone H3-K27 methylation (GO:0061085)2.39714069
142positive regulation of B cell differentiation (GO:0045579)2.39117348
143embryonic eye morphogenesis (GO:0048048)2.38996255
144COPI coating of Golgi vesicle (GO:0048205)2.38847430
145Golgi transport vesicle coating (GO:0048200)2.38847430
146protein dealkylation (GO:0008214)2.38731856
147protein demethylation (GO:0006482)2.38731856
148detection of biotic stimulus (GO:0009595)2.38637551
149regulation of necroptotic process (GO:0060544)2.38300032
150negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.38189161
151phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.37663583
152nonmotile primary cilium assembly (GO:0035058)2.37535933
153respiratory burst (GO:0045730)2.37338637
154negative chemotaxis (GO:0050919)2.36917891
155histone H3-K4 methylation (GO:0051568)2.36462049
156positive regulation of interleukin-2 production (GO:0032743)2.36045666
157facial nerve structural organization (GO:0021612)2.35937858
158axonal fasciculation (GO:0007413)2.35097746
159positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.34331465
160telencephalon cell migration (GO:0022029)2.33391165
161regulation of telomere maintenance (GO:0032204)2.32792645
162positive regulation of histone methylation (GO:0031062)2.32715161
163regulation of NFAT protein import into nucleus (GO:0051532)2.31148154
164poly(A)+ mRNA export from nucleus (GO:0016973)2.31087933
165T cell homeostasis (GO:0043029)2.30806806
166cellular response to ethanol (GO:0071361)2.30310694
167pigmentation (GO:0043473)2.30054394
168protein localization to cytoskeleton (GO:0044380)2.29716235
169response to X-ray (GO:0010165)2.29320323
170MyD88-dependent toll-like receptor signaling pathway (GO:0002755)2.29242423
171L-amino acid import (GO:0043092)2.27987539
172definitive hemopoiesis (GO:0060216)2.27863490
173neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.27795376
174postsynaptic membrane organization (GO:0001941)2.26363498
175regulation of histone methylation (GO:0031060)2.25939321
176activated T cell proliferation (GO:0050798)2.24477745
177epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.24469353
178corticosteroid receptor signaling pathway (GO:0031958)2.23678736
179diterpenoid biosynthetic process (GO:0016102)2.23670677
180regulation of nucleobase-containing compound transport (GO:0032239)2.23486123
181negative regulation of glycogen metabolic process (GO:0070874)2.23334057

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.76126727
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.12120958
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.92664291
4EZH2_22144423_ChIP-Seq_EOC_Human3.42131832
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.21170689
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.98902733
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.94018675
8GBX2_23144817_ChIP-Seq_PC3_Human2.93322102
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.84693358
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.73997862
11ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.73355555
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.67831314
13TAF15_26573619_Chip-Seq_HEK293_Human2.66775635
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60449670
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52589613
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.51362202
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42929910
18FUS_26573619_Chip-Seq_HEK293_Human2.38854930
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.33922217
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.30954505
21MYC_22102868_ChIP-Seq_BL_Human2.30479577
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16056460
23TFEB_21752829_ChIP-Seq_HELA_Human2.15247976
24* SPI1_23547873_ChIP-Seq_NB4_Human2.13747554
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.11985556
26IRF8_27001747_Chip-Seq_BMDM_Mouse2.11577142
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.10653769
28PIAS1_25552417_ChIP-Seq_VCAP_Human2.08673581
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.07209423
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04448499
31ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03683661
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.01424155
33IRF8_21731497_ChIP-ChIP_J774_Mouse2.00274000
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.99614655
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.99202500
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97705234
37MYB_26560356_Chip-Seq_TH1_Human1.90114393
38MYB_26560356_Chip-Seq_TH2_Human1.88200034
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87379745
40EWS_26573619_Chip-Seq_HEK293_Human1.86127219
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.85352666
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82098531
43P300_19829295_ChIP-Seq_ESCs_Human1.81394552
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.81252759
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.80920065
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79882688
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.78943779
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.75185327
49* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.73203708
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.72420541
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.69269543
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67608672
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67171508
54SMAD4_21799915_ChIP-Seq_A2780_Human1.65465151
55IGF1R_20145208_ChIP-Seq_DFB_Human1.64792559
56TCF7_22412390_ChIP-Seq_EML_Mouse1.64309172
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62474691
58* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60619192
59ER_23166858_ChIP-Seq_MCF-7_Human1.57383908
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.55103062
61MAF_26560356_Chip-Seq_TH1_Human1.52364664
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.50713670
63* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50210846
64* ARNT_22903824_ChIP-Seq_MCF-7_Human1.49525160
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.47879602
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47527954
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47495289
68TCF4_23295773_ChIP-Seq_U87_Human1.47041013
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46640399
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46617871
71AR_21572438_ChIP-Seq_LNCaP_Human1.46322078
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45466319
73* TP53_16413492_ChIP-PET_HCT116_Human1.45092849
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44870875
75E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44730521
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43799783
77PU_27001747_Chip-Seq_BMDM_Mouse1.43536448
78* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42670096
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42610105
80STAT3_23295773_ChIP-Seq_U87_Human1.42519450
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42428789
82* RUNX1_22412390_ChIP-Seq_EML_Mouse1.42388423
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.41812401
84ELK1_19687146_ChIP-ChIP_HELA_Human1.41127694
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40519410
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40045831
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.39788351
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39252553
89GATA1_22025678_ChIP-Seq_K562_Human1.39126491
90* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.37734746
91CIITA_25753668_ChIP-Seq_RAJI_Human1.37635481
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.37360597
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36253826
94STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35909590
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34337849
96TP53_18474530_ChIP-ChIP_U2OS_Human1.33827692
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32772094
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.32721448
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32632978
100PKCTHETA_26484144_Chip-Seq_BREAST_Human1.32335139
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32085237
102ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30442183
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.29576971
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.29525927
105E2F7_22180533_ChIP-Seq_HELA_Human1.27859333
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27402673
107P53_22387025_ChIP-Seq_ESCs_Mouse1.26377278
108JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26111899
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25926782
110* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25815839
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.25491583
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24784740
113VDR_24787735_ChIP-Seq_THP-1_Human1.24712078
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.23007731
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22922247
116TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.22805919
117VDR_21846776_ChIP-Seq_THP-1_Human1.22584302
118VDR_24763502_ChIP-Seq_THP-1_Human1.22226132
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22050280
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22050280
121* CHD1_26751641_Chip-Seq_LNCaP_Human1.21746551
122FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20739754
123ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19995909
124RNF2_27304074_Chip-Seq_NSC_Mouse1.19846106
125CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19532263
126SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19392790
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18781239
128CLOCK_20551151_ChIP-Seq_293T_Human1.18674681
129FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18547982
130CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18386498
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18317220
132PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17282884
133ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17099578
134* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16418373
135BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15985993
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15878520
137KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15781334
138SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15772700
139CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14624744
140POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14598158
141CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14329402
142DCP1A_22483619_ChIP-Seq_HELA_Human1.14142063
143* AHR_22903824_ChIP-Seq_MCF-7_Human1.13199750
144P300_18555785_Chip-Seq_ESCs_Mouse1.11410148
145RUNX_20019798_ChIP-Seq_JUKART_Human1.11316508
146* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10526205
147NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09964630
148UTX_26944678_Chip-Seq_JUKART_Human1.09784351
149STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09298468
150NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09065701
151TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09065076
152SPI1_23127762_ChIP-Seq_K562_Human1.08444630
153ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08278741
154SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08258990
155AR_25329375_ChIP-Seq_VCAP_Human1.08074144
156HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07755433
157YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07667885
158RUNX2_22187159_ChIP-Seq_PCA_Human1.07551132
159GATA3_27048872_Chip-Seq_THYMUS_Human1.07337217
160CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07114242
161EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07021161
162SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06994324
163STAT3_18555785_Chip-Seq_ESCs_Mouse1.06894065
164GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06510049
165RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05236656
166CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05097906
167STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05029061
168SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05013489
169SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05013489
170TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04783744
171CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04557659
172P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04197763
173PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03880158
174* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03123265
175OCT4_18555785_Chip-Seq_ESCs_Mouse1.00432927
176ESR1_20079471_ChIP-ChIP_T-47D_Human0.99934700
177KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99324668
178KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99195532
179NMYC_18555785_Chip-Seq_ESCs_Mouse0.98764488
180VDR_23849224_ChIP-Seq_CD4+_Human0.98297437
181KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97945646
182FOXO3_23340844_ChIP-Seq_DLD1_Human0.97280331
183FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95963700
184GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94303028
185DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94253161
186E2F1_21310950_ChIP-Seq_MCF-7_Human0.94120602
187NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92351641

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.41197745
2MP0005451_abnormal_body_composition3.16499126
3MP0008260_abnormal_autophagy2.81644348
4MP0002009_preneoplasia2.75565562
5MP0005171_absent_coat_pigmentation2.72522176
6MP0001188_hyperpigmentation2.69373127
7MP0006292_abnormal_olfactory_placode2.60730439
8MP0001835_abnormal_antigen_presentation2.55139941
9MP0005367_renal/urinary_system_phenotyp2.54591075
10MP0000516_abnormal_urinary_system2.54591075
11MP0001293_anophthalmia2.40372350
12MP0003787_abnormal_imprinting2.39912421
13MP0009278_abnormal_bone_marrow2.39632738
14MP0003763_abnormal_thymus_physiology2.36790871
15MP0003724_increased_susceptibility_to2.30557789
16MP0008057_abnormal_DNA_replication2.26858161
17MP0003436_decreased_susceptibility_to2.26754969
18MP0005645_abnormal_hypothalamus_physiol2.25298361
19MP0003303_peritoneal_inflammation2.24561942
20MP0005409_darkened_coat_color2.23562711
21MP0003191_abnormal_cellular_cholesterol2.23157881
22MP0002166_altered_tumor_susceptibility2.14423162
23MP0005174_abnormal_tail_pigmentation2.14382884
24MP0000778_abnormal_nervous_system2.14136755
25MP0010234_abnormal_vibrissa_follicle2.11518236
26MP0003221_abnormal_cardiomyocyte_apopto2.09689859
27MP0000015_abnormal_ear_pigmentation2.01469639
28MP0003937_abnormal_limbs/digits/tail_de1.90655030
29MP0001800_abnormal_humoral_immune1.89364658
30MP0003183_abnormal_peptide_metabolism1.85572250
31MP0000920_abnormal_myelination1.82909156
32MP0003091_abnormal_cell_migration1.82262840
33MP0003656_abnormal_erythrocyte_physiolo1.80762587
34MP0003890_abnormal_embryonic-extraembry1.77530225
35MP0002396_abnormal_hematopoietic_system1.77264979
36MP0001346_abnormal_lacrimal_gland1.76160844
37MP0002419_abnormal_innate_immunity1.74517030
38MP0008789_abnormal_olfactory_epithelium1.66920693
39MP0002398_abnormal_bone_marrow1.66475507
40MP0005000_abnormal_immune_tolerance1.66309028
41MP0003121_genomic_imprinting1.64929390
42MP0002452_abnormal_antigen_presenting1.64611538
43MP0009785_altered_susceptibility_to1.61948537
44MP0000685_abnormal_immune_system1.60665401
45MP0000631_abnormal_neuroendocrine_gland1.60587702
46MP0002723_abnormal_immune_serum1.60295115
47MP0002938_white_spotting1.60213893
48MP0003828_pulmonary_edema1.58120623
49MP0003950_abnormal_plasma_membrane1.56376237
50MP0000703_abnormal_thymus_morphology1.55936542
51MP0002420_abnormal_adaptive_immunity1.55500718
52MP0000678_abnormal_parathyroid_gland1.55386812
53MP0002006_tumorigenesis1.54441157
54MP0001819_abnormal_immune_cell1.54191072
55MP0002277_abnormal_respiratory_mucosa1.53942544
56MP0002405_respiratory_system_inflammati1.53735902
57MP0004947_skin_inflammation1.53602825
58MP0002095_abnormal_skin_pigmentation1.51558412
59MP0005671_abnormal_response_to1.44417957
60MP0004808_abnormal_hematopoietic_stem1.42551834
61MP0009697_abnormal_copulation1.40630379
62MP0005025_abnormal_response_to1.40552691
63MP0002132_abnormal_respiratory_system1.40166224
64MP0002722_abnormal_immune_system1.39013888
65MP0008877_abnormal_DNA_methylation1.38832028
66MP0000689_abnormal_spleen_morphology1.38526844
67MP0005387_immune_system_phenotype1.38178073
68MP0001790_abnormal_immune_system1.38178073
69MP0003122_maternal_imprinting1.37859492
70MP0000716_abnormal_immune_system1.36630313
71MP0003077_abnormal_cell_cycle1.36129487
72MP0002233_abnormal_nose_morphology1.34394465
73MP0001286_abnormal_eye_development1.34143805
74MP0002177_abnormal_outer_ear1.34041600
75MP0005464_abnormal_platelet_physiology1.33336294
76MP0005623_abnormal_meninges_morphology1.33166832
77MP0002877_abnormal_melanocyte_morpholog1.32912865
78MP0003566_abnormal_cell_adhesion1.32482652
79MP0002163_abnormal_gland_morphology1.31635322
80MP0000049_abnormal_middle_ear1.30752095
81MP0004185_abnormal_adipocyte_glucose1.28536358
82MP0004134_abnormal_chest_morphology1.27364366
83MP0010155_abnormal_intestine_physiology1.27034309
84MP0003935_abnormal_craniofacial_develop1.26459553
85MP0000490_abnormal_crypts_of1.25229309
86MP0000681_abnormal_thyroid_gland1.25097868
87MP0004883_abnormal_blood_vessel1.24744070
88MP0004885_abnormal_endolymph1.24650253
89MP0000858_altered_metastatic_potential1.23201694
90MP0003453_abnormal_keratinocyte_physiol1.21685450
91MP0002249_abnormal_larynx_morphology1.21346661
92MP0005397_hematopoietic_system_phenotyp1.20888053
93MP0001545_abnormal_hematopoietic_system1.20888053
94MP0003300_gastrointestinal_ulcer1.19678996
95MP0005621_abnormal_cell_physiology1.19020288
96MP0004381_abnormal_hair_follicle1.18890439
97MP0002429_abnormal_blood_cell1.17623065
98MP0001915_intracranial_hemorrhage1.17186563
99MP0004264_abnormal_extraembryonic_tissu1.17102032
100MP0005310_abnormal_salivary_gland1.16929108
101MP0000350_abnormal_cell_proliferation1.16593147
102MP0009703_decreased_birth_body1.16352999
103MP0001486_abnormal_startle_reflex1.15327171
104MP0005076_abnormal_cell_differentiation1.15254511
105MP0001270_distended_abdomen1.14709992
106MP0001853_heart_inflammation1.14183625
107MP0003136_yellow_coat_color1.13560233
108MP0003943_abnormal_hepatobiliary_system1.12555594
109MP0002160_abnormal_reproductive_system1.11998877
110MP0002332_abnormal_exercise_endurance1.10568937
111MP0006072_abnormal_retinal_apoptosis1.08676413
112MP0002998_abnormal_bone_remodeling1.08674952
113MP0005187_abnormal_penis_morphology1.08535836
114MP0006054_spinal_hemorrhage1.06952562
115MP0002092_abnormal_eye_morphology1.05758048
116MP0005391_vision/eye_phenotype1.05745697
117MP0003172_abnormal_lysosome_physiology1.05406778
118MP0000566_synostosis1.04394246
119MP0003385_abnormal_body_wall1.04380071
120MP0003861_abnormal_nervous_system1.02386914
121MP0003705_abnormal_hypodermis_morpholog1.02108807
122MP0002928_abnormal_bile_duct1.01701793
123MP0005058_abnormal_lysosome_morphology1.01639206
124MP0005253_abnormal_eye_physiology1.01026113
125MP0009333_abnormal_splenocyte_physiolog1.00405563
126MP0001177_atelectasis0.99450574
127MP0000371_diluted_coat_color0.98766033
128MP0001845_abnormal_inflammatory_respons0.98047263
129MP0000465_gastrointestinal_hemorrhage0.97704083
130MP0002086_abnormal_extraembryonic_tissu0.96925858
131MP0005384_cellular_phenotype0.96302905
132MP0003448_altered_tumor_morphology0.96059613
133MP0010678_abnormal_skin_adnexa0.94526673
134MP0005394_taste/olfaction_phenotype0.93849491
135MP0005499_abnormal_olfactory_system0.93849491
136MP0005646_abnormal_pituitary_gland0.93389420
137MP0004957_abnormal_blastocyst_morpholog0.93023202
138MP0003632_abnormal_nervous_system0.92388003
139MP0002697_abnormal_eye_size0.92103678
140MP0002148_abnormal_hypersensitivity_rea0.91785884
141MP0003984_embryonic_growth_retardation0.91779861
142MP0001324_abnormal_eye_pigmentation0.91443675
143MP0002088_abnormal_embryonic_growth/wei0.91114139
144MP0002796_impaired_skin_barrier0.91087943
145MP0004742_abnormal_vestibular_system0.91002414
146MP0001730_embryonic_growth_arrest0.90042795
147MP0005551_abnormal_eye_electrophysiolog0.89790928
148MP0000537_abnormal_urethra_morphology0.89448978
149MP0003755_abnormal_palate_morphology0.89355588
150MP0005379_endocrine/exocrine_gland_phen0.87978896
151MP0010307_abnormal_tumor_latency0.87118301
152MP0000955_abnormal_spinal_cord0.86825356
153MP0009250_abnormal_appendicular_skeleto0.86588408
154MP0005248_abnormal_Harderian_gland0.86461928
155MP0003634_abnormal_glial_cell0.86208116
156MP0005380_embryogenesis_phenotype0.85438000
157MP0001672_abnormal_embryogenesis/_devel0.85438000
158MP0002019_abnormal_tumor_incidence0.85210446
159MP0009384_cardiac_valve_regurgitation0.84073624
160MP0002882_abnormal_neuron_morphology0.83971188
161MP0001851_eye_inflammation0.83493029
162MP0005195_abnormal_posterior_eye0.82618637
163MP0001984_abnormal_olfaction0.82097685
164MP0000427_abnormal_hair_cycle0.81824316
165MP0003111_abnormal_nucleus_morphology0.81817169
166MP0002152_abnormal_brain_morphology0.80891648
167MP0000432_abnormal_head_morphology0.80640455
168MP0001533_abnormal_skeleton_physiology0.80542106
169MP0010094_abnormal_chromosome_stability0.80073990
170MP0001216_abnormal_epidermal_layer0.79924293
171MP0008961_abnormal_basal_metabolism0.79918439
172MP0001986_abnormal_taste_sensitivity0.78792395
173MP0000534_abnormal_ureter_morphology0.78341113
174MP0000613_abnormal_salivary_gland0.78297550
175MP0003567_abnormal_fetal_cardiomyocyte0.77878862
176MP0000003_abnormal_adipose_tissue0.77745737
177MP0005075_abnormal_melanosome_morpholog0.77505640
178MP0010352_gastrointestinal_tract_polyps0.76782694
179MP0002557_abnormal_social/conspecific_i0.76732482
180MP0001697_abnormal_embryo_size0.76565993
181MP0002638_abnormal_pupillary_reflex0.76251408
182MP0008058_abnormal_DNA_repair0.76059461
183MP0005164_abnormal_response_to0.74970904
184MP0002752_abnormal_somatic_nervous0.74446436
185MP0003942_abnormal_urinary_system0.73661813
186MP0002116_abnormal_craniofacial_bone0.72853306

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.74759741
2Volvulus (HP:0002580)3.37870167
3Subacute progressive viral hepatitis (HP:0006572)3.36989203
4Termporal pattern (HP:0011008)3.22486982
5Insidious onset (HP:0003587)3.22486982
6T lymphocytopenia (HP:0005403)3.21299717
7Recurrent bacterial skin infections (HP:0005406)3.14249710
8Recurrent abscess formation (HP:0002722)3.02328316
9Curly hair (HP:0002212)2.91922540
10Chromsome breakage (HP:0040012)2.87605083
11Abnormal hair whorl (HP:0010721)2.84466406
12Recurrent viral infections (HP:0004429)2.81191559
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.80594238
14Thyroid carcinoma (HP:0002890)2.80244273
15Tetraparesis (HP:0002273)2.67678236
16Tubulointerstitial nephritis (HP:0001970)2.66415962
17Abnormality of T cell number (HP:0011839)2.66309333
18Viral hepatitis (HP:0006562)2.65596473
19Macroorchidism (HP:0000053)2.60484357
20Bladder neoplasm (HP:0009725)2.59841308
21Bladder carcinoma (HP:0002862)2.59841308
22Hip dysplasia (HP:0001385)2.58643768
23Retrobulbar optic neuritis (HP:0100654)2.58600188
24Optic neuritis (HP:0100653)2.58600188
25Lip pit (HP:0100267)2.54102671
26Abnormality of the fingertips (HP:0001211)2.52464595
27Transitional cell carcinoma of the bladder (HP:0006740)2.52035211
28Keratoconjunctivitis sicca (HP:0001097)2.50393150
29Spontaneous hematomas (HP:0007420)2.48825785
30Panhypogammaglobulinemia (HP:0003139)2.47961385
31Abnormal foot bone ossification (HP:0010675)2.47823258
32Hypothermia (HP:0002045)2.47488391
33Cupped ear (HP:0000378)2.47389119
34Mediastinal lymphadenopathy (HP:0100721)2.43953311
35Orchitis (HP:0100796)2.43572167
36Micronodular cirrhosis (HP:0001413)2.41670850
37Abnormality of macrophages (HP:0004311)2.41046736
38Type I transferrin isoform profile (HP:0003642)2.40968398
39Sensory axonal neuropathy (HP:0003390)2.40106323
40Hyperventilation (HP:0002883)2.39551871
41White forelock (HP:0002211)2.38324278
42Asymmetry of the thorax (HP:0001555)2.36588072
43Abnormality of the renal collecting system (HP:0004742)2.36172313
44Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.35174315
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.31626583
46Degeneration of the lateral corticospinal tracts (HP:0002314)2.31626583
47Recurrent fungal infections (HP:0002841)2.31140416
48Fair hair (HP:0002286)2.31094662
49Abnormality of DNA repair (HP:0003254)2.30370006
50Renal cell carcinoma (HP:0005584)2.28268793
51Leiomyosarcoma (HP:0100243)2.25610951
52Uterine leiomyosarcoma (HP:0002891)2.25610951
53Rectal prolapse (HP:0002035)2.24588155
54Gastrointestinal carcinoma (HP:0002672)2.21641266
55Malignant gastrointestinal tract tumors (HP:0006749)2.21641266
56Parakeratosis (HP:0001036)2.18414878
57Cellulitis (HP:0100658)2.17523555
58Osteomyelitis (HP:0002754)2.15983198
59Meningitis (HP:0001287)2.14568772
60Recurrent gram-negative bacterial infections (HP:0005420)2.14345278
61Tapered finger (HP:0001182)2.13778879
62Ectopic kidney (HP:0000086)2.13264198
63Abnormality of the nasal septum (HP:0000419)2.12333318
64B lymphocytopenia (HP:0010976)2.12297262
65Recurrent skin infections (HP:0001581)2.10601998
66Ankyloglossia (HP:0010296)2.10582470
67Abnormal tarsal ossification (HP:0008369)2.10115514
68Aplasia cutis congenita (HP:0001057)2.09183666
69Urticaria (HP:0001025)2.09169336
70Spinal cord lesions (HP:0100561)2.07505649
71Syringomyelia (HP:0003396)2.07505649
72Patchy hypopigmentation of hair (HP:0011365)2.06533232
73Excessive salivation (HP:0003781)2.06005902
74Drooling (HP:0002307)2.06005902
75Periodontitis (HP:0000704)2.05622155
76Open mouth (HP:0000194)2.04626498
77Reduced antithrombin III activity (HP:0001976)2.04509819
78Keratoconjunctivitis (HP:0001096)2.03574826
79Disinhibition (HP:0000734)2.03141901
80Myositis (HP:0100614)2.02854688
81Gingivitis (HP:0000230)2.02192569
82Gingival bleeding (HP:0000225)2.01541334
83Molar tooth sign on MRI (HP:0002419)2.01141985
84Abnormality of midbrain morphology (HP:0002418)2.01141985
85Aqueductal stenosis (HP:0002410)1.98441300
86Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97278548
87Papillary thyroid carcinoma (HP:0002895)1.97190502
88Medulloblastoma (HP:0002885)1.97046467
89Absent frontal sinuses (HP:0002688)1.96856722
90Widely spaced teeth (HP:0000687)1.96483687
91Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.95381692
92Acute hepatic failure (HP:0006554)1.95172895
93Fatigue (HP:0012378)1.93522391
94Basal cell carcinoma (HP:0002671)1.92981544
95Febrile seizures (HP:0002373)1.92147659
96Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91850217
97Abnormal delayed hypersensitivity skin test (HP:0002963)1.91651908
98Coarse hair (HP:0002208)1.91106271
99Thyroiditis (HP:0100646)1.89578440
100Duplicated collecting system (HP:0000081)1.89264687
101Abnormality of oral frenula (HP:0000190)1.88236587
102Inflammation of the large intestine (HP:0002037)1.87825497
103Low anterior hairline (HP:0000294)1.87595351
104Atonic seizures (HP:0010819)1.87577627
105Colitis (HP:0002583)1.87336908
106Increased number of teeth (HP:0011069)1.87208284
107Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.85770182
108Colon cancer (HP:0003003)1.84924729
109Decreased lacrimation (HP:0000633)1.84784989
110Gastrointestinal inflammation (HP:0004386)1.84686953
111Recurrent cutaneous fungal infections (HP:0011370)1.84560409
112Chronic mucocutaneous candidiasis (HP:0002728)1.84560409
113Duplication of thumb phalanx (HP:0009942)1.84020223
114Prominent nose (HP:0000448)1.83521065
115Aplasia/Hypoplasia of the uvula (HP:0010293)1.83486600
116Smooth philtrum (HP:0000319)1.83397168
117Dyschromatopsia (HP:0007641)1.83372386
118Congenital sensorineural hearing impairment (HP:0008527)1.82654530
119Bony spicule pigmentary retinopathy (HP:0007737)1.81391399
120Slow saccadic eye movements (HP:0000514)1.81066949
121Autoamputation (HP:0001218)1.80654792
122Anteriorly placed anus (HP:0001545)1.80485319
123Heterotopia (HP:0002282)1.80409546
124Intestinal fistula (HP:0100819)1.79996528
125Vasculitis (HP:0002633)1.78931178
126Deviation of the thumb (HP:0009603)1.78821606
127Delayed closure of the anterior fontanelle (HP:0001476)1.78300061
128Pelvic girdle muscle weakness (HP:0003749)1.77234640
129Chronic hepatic failure (HP:0100626)1.77131200
130Narrow palate (HP:0000189)1.76998393
131Leukocytosis (HP:0001974)1.76634309
132Broad distal phalanx of finger (HP:0009836)1.75995597
133Weak cry (HP:0001612)1.75549405
134Gastrointestinal infarctions (HP:0005244)1.74968808
135Abnormality of the parietal bone (HP:0002696)1.73993867
136Generalized hypopigmentation of hair (HP:0011358)1.73377081
137Hypoplastic labia majora (HP:0000059)1.72722397
138Severe combined immunodeficiency (HP:0004430)1.71994231
139Esophageal atresia (HP:0002032)1.71785510
140Focal motor seizures (HP:0011153)1.71735476
141Flat face (HP:0012368)1.71435059
142Rhabdomyosarcoma (HP:0002859)1.71295788
143Anhidrosis (HP:0000970)1.70190930
144Eosinophilia (HP:0001880)1.69936199
145Granulocytopenia (HP:0001913)1.69782870
146Osteolytic defects of the phalanges of the hand (HP:0009771)1.69582487
147Osteolytic defects of the hand bones (HP:0009699)1.69582487
148Abnormality of the preputium (HP:0100587)1.69345072
149Blue irides (HP:0000635)1.68152076
150Proximal placement of thumb (HP:0009623)1.67611817
151Spondylolisthesis (HP:0003302)1.67253394
152True hermaphroditism (HP:0010459)1.67041605
153Protruding tongue (HP:0010808)1.66901832
154Hematochezia (HP:0002573)1.66850620
155Abnormal protein glycosylation (HP:0012346)1.66681300
156Abnormal glycosylation (HP:0012345)1.66681300
157Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.66681300
158Abnormal protein N-linked glycosylation (HP:0012347)1.66681300
159Thickened calvaria (HP:0002684)1.66268555
160Myocardial infarction (HP:0001658)1.66070629
161Decreased central vision (HP:0007663)1.64632950
162Acute myeloid leukemia (HP:0004808)1.64277620
163Abnormality of the carotid arteries (HP:0005344)1.63853668
164Gastrointestinal stroma tumor (HP:0100723)1.63487905
165Abnormality of B cell number (HP:0010975)1.63339716
166Nephronophthisis (HP:0000090)1.63096525
167Buphthalmos (HP:0000557)1.62747734
168Peritonitis (HP:0002586)1.62610315
169Long eyelashes (HP:0000527)1.61627202
170Severe visual impairment (HP:0001141)1.61541255
171Abnormality of incisor morphology (HP:0011063)1.60850328
172Abnormality of the right ventricle (HP:0001707)1.60366385
173Abnormality of the columella (HP:0009929)1.59655694
174Deep philtrum (HP:0002002)1.59474038
175Gastroesophageal reflux (HP:0002020)1.59226197
176Stomach cancer (HP:0012126)1.58756716
177Cutaneous finger syndactyly (HP:0010554)1.58633268
178Heterochromia iridis (HP:0001100)1.57276228
179Urethral obstruction (HP:0000796)1.56589342
180Clubbing of toes (HP:0100760)1.56372053
181Abnormality of the labia majora (HP:0012881)1.55480031
182Bell-shaped thorax (HP:0001591)1.53742140
183Ectropion (HP:0000656)1.53711793
184Abnormality of the renal medulla (HP:0100957)1.53190055
185Absent eyebrow (HP:0002223)1.53183367
186Central scotoma (HP:0000603)1.51695716
187Highly arched eyebrow (HP:0002553)1.51578057
188Microtia (HP:0008551)1.50912124
189Hypoplasia of the iris (HP:0007676)1.50787258
190Astigmatism (HP:0000483)1.50598505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.22825193
2FRK2.74241993
3PRPF4B2.70164708
4MAP3K102.70138591
5YES12.48718316
6MKNK22.44697488
7EIF2AK32.38991452
8MKNK12.33406095
9CDK82.19190136
10INSRR2.16237752
11TYK22.14925529
12BRD42.06873484
13TNIK1.98434365
14IKBKE1.92541802
15MAP2K71.91139148
16FGFR21.89057103
17KSR21.88866418
18IRAK41.86422136
19KSR11.84517041
20PIK3CG1.78542464
21EPHB11.74297359
22ERBB31.71075035
23MAP3K131.69904403
24SCYL21.69366042
25RPS6KA41.68313394
26MAP4K11.65523884
27CDK121.60410155
28STK391.56592533
29MAPK131.54057470
30CDK61.46016883
31MAP2K31.43249664
32AKT31.41148536
33SGK2231.39908347
34SGK4941.39908347
35NLK1.36017058
36MAP3K31.35319662
37CSNK1A1L1.33760505
38SGK21.30749061
39BLK1.29033878
40CSNK1G11.27390825
41RAF11.27214434
42TRPM71.26823389
43MUSK1.24647586
44STK31.23728671
45MAP3K41.23130904
46ZAK1.23026790
47DYRK31.22188954
48TRIM281.20961574
49NEK91.20699823
50CDK41.18122865
51CLK11.17624145
52PASK1.16580129
53TRIB31.16384363
54FLT31.15575271
55TXK1.15429311
56TBK11.14364151
57ACVR1B1.14162372
58ICK1.13644449
59MAP3K121.12794275
60MELK1.12348388
61JAK31.11849372
62MAP3K141.11724504
63GRK61.11144749
64FGFR41.09697475
65CAMK1G1.09055949
66BMPR21.08972003
67PRKCQ1.07807201
68HCK1.07518870
69SGK31.02865519
70IRAK31.02369283
71MAP3K11.01126471
72PNCK0.97935184
73PAK30.96763805
74CSNK1G20.96019983
75FGR0.95021918
76EPHA30.92884097
77RPS6KB10.92465552
78CSNK1G30.91347485
79OXSR10.91037016
80MAP3K50.89824756
81JAK20.88881959
82FGFR30.87648468
83STK100.87226597
84CAMKK20.86156035
85MARK20.84303816
86ITK0.83802778
87MATK0.82686677
88PKN10.82022750
89MAPK70.81703679
90PIM10.81375888
91CDK30.80273315
92SIK30.78840412
93PRKD30.77289182
94TAOK10.76635063
95CHUK0.76297737
96NTRK20.76063151
97TEC0.75258238
98UHMK10.74849363
99PIK3CA0.73970028
100PKN20.73720608
101SIK10.73055728
102LMTK20.71551321
103BTK0.71100501
104PLK20.71013257
105PRKD20.70951290
106ZAP700.70901918
107IRAK10.70883175
108LATS10.69763865
109MAP2K40.69317177
110MAP3K60.69240751
111MARK30.66919374
112SGK10.65949689
113IKBKB0.65638125
114PRKCH0.64547493
115WNK10.63680658
116DMPK0.62764042
117PBK0.60773142
118RET0.60646846
119SRPK10.60401753
120GRK10.59926124
121NEK60.58601155
122FES0.58412023
123PDGFRB0.57092994
124BCR0.56205034
125MAPK150.56127449
126DYRK1B0.55489645
127SYK0.55283509
128LYN0.55078170
129IRAK20.54537339
130ATM0.54430098
131MAPKAPK50.54225934
132CAMK1D0.53238588
133EIF2AK10.50691118
134CSK0.49512804
135CSF1R0.49511367
136STK40.49369894
137FYN0.48646593
138MAP3K90.47287788
139RPS6KA20.47277974
140LCK0.47257116
141TAOK30.47031865
142KIT0.46586073
143RIPK40.46192122
144ADRBK10.45303989
145PDK10.45132500
146ROCK20.44814198
147CDC70.44747451
148GRK70.44742742
149RPS6KA50.44708416
150JAK10.44227155
151CAMK40.44036902
152STK110.42984263
153EGFR0.42645732
154STK240.42190915
155MAP3K20.41058363
156CHEK10.37694477
157TAOK20.34849965
158FGFR10.33726490
159LRRK20.33346105

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009202.18911442
2Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.03468158
3Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82968418
4Axon guidance_Homo sapiens_hsa043601.64273731
5Legionellosis_Homo sapiens_hsa051341.59464391
6Thyroid cancer_Homo sapiens_hsa052161.58289804
7Prostate cancer_Homo sapiens_hsa052151.49366572
8Herpes simplex infection_Homo sapiens_hsa051681.48870779
9Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.48042759
10Hepatitis C_Homo sapiens_hsa051601.47302944
11Influenza A_Homo sapiens_hsa051641.47215676
12Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.47168521
13Tuberculosis_Homo sapiens_hsa051521.46685771
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.46252227
15Transcriptional misregulation in cancer_Homo sapiens_hsa052021.45591625
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45277676
17Non-homologous end-joining_Homo sapiens_hsa034501.44431939
18Shigellosis_Homo sapiens_hsa051311.44013559
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42797281
20Colorectal cancer_Homo sapiens_hsa052101.41273893
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.40246653
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.39347507
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37833400
24Phototransduction_Homo sapiens_hsa047441.36507462
25Pancreatic cancer_Homo sapiens_hsa052121.33701336
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.31646482
27Fanconi anemia pathway_Homo sapiens_hsa034601.31320193
28MicroRNAs in cancer_Homo sapiens_hsa052061.29020390
29Serotonergic synapse_Homo sapiens_hsa047261.27706961
30Taste transduction_Homo sapiens_hsa047421.27638323
31Dorso-ventral axis formation_Homo sapiens_hsa043201.25490507
32Histidine metabolism_Homo sapiens_hsa003401.24013013
33mTOR signaling pathway_Homo sapiens_hsa041501.22463348
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21340666
35Autoimmune thyroid disease_Homo sapiens_hsa053201.20350737
36TNF signaling pathway_Homo sapiens_hsa046681.19786626
37Apoptosis_Homo sapiens_hsa042101.17610190
38Protein export_Homo sapiens_hsa030601.16686010
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13072520
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12128123
41Asthma_Homo sapiens_hsa053101.11892468
42Adherens junction_Homo sapiens_hsa045201.11221328
43Wnt signaling pathway_Homo sapiens_hsa043101.10916585
44ErbB signaling pathway_Homo sapiens_hsa040121.10585020
45Endometrial cancer_Homo sapiens_hsa052131.09145966
46Epstein-Barr virus infection_Homo sapiens_hsa051691.08801734
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.08743605
48Non-small cell lung cancer_Homo sapiens_hsa052231.08495300
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08058745
50FoxO signaling pathway_Homo sapiens_hsa040681.08036163
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07399341
52Sphingolipid metabolism_Homo sapiens_hsa006001.06290085
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.05997067
54Small cell lung cancer_Homo sapiens_hsa052221.05173027
55Long-term depression_Homo sapiens_hsa047301.04587187
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02997075
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01503888
58Type II diabetes mellitus_Homo sapiens_hsa049301.01240489
59Ether lipid metabolism_Homo sapiens_hsa005651.00377239
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00266813
61Renal cell carcinoma_Homo sapiens_hsa052110.99935656
62Olfactory transduction_Homo sapiens_hsa047400.99331254
63Glioma_Homo sapiens_hsa052140.97616180
64Inositol phosphate metabolism_Homo sapiens_hsa005620.97444788
65T cell receptor signaling pathway_Homo sapiens_hsa046600.96755278
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96464710
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.94832869
68Steroid biosynthesis_Homo sapiens_hsa001000.94513417
69Cholinergic synapse_Homo sapiens_hsa047250.94261985
70Systemic lupus erythematosus_Homo sapiens_hsa053220.94199457
71Alcoholism_Homo sapiens_hsa050340.93311613
72Melanoma_Homo sapiens_hsa052180.92998833
73Glutamatergic synapse_Homo sapiens_hsa047240.92279051
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91611569
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.91269805
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90554631
77HIF-1 signaling pathway_Homo sapiens_hsa040660.89800976
78Leishmaniasis_Homo sapiens_hsa051400.89625707
79Chronic myeloid leukemia_Homo sapiens_hsa052200.89515051
80Hematopoietic cell lineage_Homo sapiens_hsa046400.89276652
81Malaria_Homo sapiens_hsa051440.88843877
82Pathways in cancer_Homo sapiens_hsa052000.88124710
83Other glycan degradation_Homo sapiens_hsa005110.87210095
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87037636
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85515304
86Hippo signaling pathway_Homo sapiens_hsa043900.84740191
87Proteoglycans in cancer_Homo sapiens_hsa052050.84447887
88Viral myocarditis_Homo sapiens_hsa054160.83849396
89Chemokine signaling pathway_Homo sapiens_hsa040620.83800654
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83497405
91HTLV-I infection_Homo sapiens_hsa051660.82576115
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.82265521
93Salmonella infection_Homo sapiens_hsa051320.82247160
94Primary immunodeficiency_Homo sapiens_hsa053400.81987473
95B cell receptor signaling pathway_Homo sapiens_hsa046620.81980013
96VEGF signaling pathway_Homo sapiens_hsa043700.80723597
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79980360
98Circadian rhythm_Homo sapiens_hsa047100.79899153
99Morphine addiction_Homo sapiens_hsa050320.79854631
100Platelet activation_Homo sapiens_hsa046110.79600252
101p53 signaling pathway_Homo sapiens_hsa041150.79482019
102Endocytosis_Homo sapiens_hsa041440.78771024
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78605959
104Insulin signaling pathway_Homo sapiens_hsa049100.77882529
105Cell cycle_Homo sapiens_hsa041100.77245516
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76598808
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76161017
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.75970337
109TGF-beta signaling pathway_Homo sapiens_hsa043500.75853046
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.75720915
111Bladder cancer_Homo sapiens_hsa052190.75370503
112Insulin resistance_Homo sapiens_hsa049310.74916744
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74653140
114Acute myeloid leukemia_Homo sapiens_hsa052210.73801082
115Notch signaling pathway_Homo sapiens_hsa043300.72828568
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72514644
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72366502
118Measles_Homo sapiens_hsa051620.71361452
119Phagosome_Homo sapiens_hsa041450.70139416
120Prolactin signaling pathway_Homo sapiens_hsa049170.69702028
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69560341
122Amoebiasis_Homo sapiens_hsa051460.69219856
123mRNA surveillance pathway_Homo sapiens_hsa030150.69202315
124Osteoclast differentiation_Homo sapiens_hsa043800.69155357
125Rap1 signaling pathway_Homo sapiens_hsa040150.69084521
126Staphylococcus aureus infection_Homo sapiens_hsa051500.68890425
127Long-term potentiation_Homo sapiens_hsa047200.68630034
128Toxoplasmosis_Homo sapiens_hsa051450.67819989
129N-Glycan biosynthesis_Homo sapiens_hsa005100.67806722
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65475556
131Estrogen signaling pathway_Homo sapiens_hsa049150.65170531
132Ovarian steroidogenesis_Homo sapiens_hsa049130.64472992
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.64347223
134Ras signaling pathway_Homo sapiens_hsa040140.63765050
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63361951
136Dopaminergic synapse_Homo sapiens_hsa047280.62944703
137Choline metabolism in cancer_Homo sapiens_hsa052310.62866122
138Pertussis_Homo sapiens_hsa051330.62411347
139Viral carcinogenesis_Homo sapiens_hsa052030.62115272
140Basal cell carcinoma_Homo sapiens_hsa052170.61867371
141Lysine degradation_Homo sapiens_hsa003100.60574610
142Hepatitis B_Homo sapiens_hsa051610.59522216
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58346762
144MAPK signaling pathway_Homo sapiens_hsa040100.57292942
145Focal adhesion_Homo sapiens_hsa045100.56234449
146RNA transport_Homo sapiens_hsa030130.56071202
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55747230
148Circadian entrainment_Homo sapiens_hsa047130.55686659
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.53666781
150Allograft rejection_Homo sapiens_hsa053300.53317986
151African trypanosomiasis_Homo sapiens_hsa051430.49095544
152Spliceosome_Homo sapiens_hsa030400.46690889

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