ASB8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.36041818
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.65877498
3maintenance of protein location in nucleus (GO:0051457)6.56947721
4negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.55501067
5cytidine deamination (GO:0009972)6.43140127
6cytidine metabolic process (GO:0046087)6.43140127
7cytidine catabolic process (GO:0006216)6.43140127
8negative regulation of cell cycle G2/M phase transition (GO:1902750)6.00333174
9somite rostral/caudal axis specification (GO:0032525)5.84005631
10regulation of cilium movement (GO:0003352)5.82117260
11regulation of mammary gland epithelial cell proliferation (GO:0033599)5.81634165
12regulation of response to osmotic stress (GO:0047484)5.67685206
13regulation of skeletal muscle contraction (GO:0014819)5.63436440
14coenzyme catabolic process (GO:0009109)5.53785786
15negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.50164639
16actin-myosin filament sliding (GO:0033275)5.38440078
17muscle filament sliding (GO:0030049)5.38440078
18negative regulation of potassium ion transmembrane transport (GO:1901380)5.37046072
19quinone metabolic process (GO:1901661)5.28483081
20negative regulation of epidermis development (GO:0045683)5.26412294
21cullin deneddylation (GO:0010388)5.25585151
22regulation of nuclear cell cycle DNA replication (GO:0033262)5.15119329
23pyrimidine ribonucleoside catabolic process (GO:0046133)5.14783665
24histone H4-K5 acetylation (GO:0043981)5.11192658
25histone H4-K8 acetylation (GO:0043982)5.11192658
26sarcoplasmic reticulum calcium ion transport (GO:0070296)5.05634811
27protein deneddylation (GO:0000338)5.01372070
28regulation of telomere maintenance via telomerase (GO:0032210)4.97175314
29regulation of MHC class I biosynthetic process (GO:0045343)4.91946599
30muscle organ morphogenesis (GO:0048644)4.91932980
31rRNA transcription (GO:0009303)4.82564281
32rRNA methylation (GO:0031167)4.76285195
33negative regulation of telomerase activity (GO:0051974)4.72773687
34histone H4-K12 acetylation (GO:0043983)4.66818475
35mitotic sister chromatid segregation (GO:0000070)4.59681903
36protein localization to kinetochore (GO:0034501)4.56352924
37phenol-containing compound catabolic process (GO:0019336)4.46162268
38behavioral response to nicotine (GO:0035095)4.39381187
39actin-mediated cell contraction (GO:0070252)4.36229758
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.35026730
41regulation of relaxation of muscle (GO:1901077)4.33564039
42interferon-gamma production (GO:0032609)4.29603799
43microtubule severing (GO:0051013)4.27416554
44positive regulation of DNA-dependent DNA replication (GO:2000105)4.25920923
45protein polyglutamylation (GO:0018095)4.17647999
46negative regulation of telomere maintenance (GO:0032205)4.15225397
47hormone catabolic process (GO:0042447)4.15100097
48nucleoside transmembrane transport (GO:1901642)4.13964188
49notochord development (GO:0030903)4.12861214
50mitochondrion distribution (GO:0048311)4.12299641
51rRNA modification (GO:0000154)4.10784853
52negative regulation of epidermal cell differentiation (GO:0045605)4.07268427
53skeletal muscle contraction (GO:0003009)4.05921707
54response to dietary excess (GO:0002021)4.01553781
55histone H4-K16 acetylation (GO:0043984)3.74850341
56cellular modified amino acid catabolic process (GO:0042219)3.74038632
57calcium-mediated signaling using intracellular calcium source (GO:0035584)3.73060260
58tricarboxylic acid cycle (GO:0006099)3.66758651
59response to pheromone (GO:0019236)3.59322944
60regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.58676313
61regulation of microtubule-based movement (GO:0060632)3.56154757
62maintenance of protein localization in organelle (GO:0072595)3.55516478
63DNA replication checkpoint (GO:0000076)3.48616886
64sister chromatid segregation (GO:0000819)3.47892871
65response to inactivity (GO:0014854)3.43436977
66transcription from mitochondrial promoter (GO:0006390)3.42664178
67regulation of apoptotic process involved in morphogenesis (GO:1902337)3.38795223
68primitive streak formation (GO:0090009)3.38762097
69regulation of membrane repolarization (GO:0060306)3.35481551
70regulation of G0 to G1 transition (GO:0070316)3.34474392
71biotin metabolic process (GO:0006768)3.33029329
72pyrimidine nucleobase catabolic process (GO:0006208)3.32674299
73nucleoside transport (GO:0015858)3.31447604
74epoxygenase P450 pathway (GO:0019373)3.30028608
75protein localization to chromosome, centromeric region (GO:0071459)3.29379446
76GDP-mannose metabolic process (GO:0019673)3.27322919
77negative regulation of systemic arterial blood pressure (GO:0003085)3.27208456
78synaptic transmission, cholinergic (GO:0007271)3.26947769
79neuronal action potential propagation (GO:0019227)3.26319435
80positive regulation of protein deacetylation (GO:0090312)3.23435358
81regulation of translation in response to stress (GO:0043555)3.22300327
82positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.20181426
83detection of temperature stimulus (GO:0016048)3.17527347
84regulation of telomerase activity (GO:0051972)3.16937790
85striated muscle contraction (GO:0006941)3.16907734
86myofibril assembly (GO:0030239)3.16821518
87regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.13209927
88DNA replication-dependent nucleosome organization (GO:0034723)3.12592413
89DNA replication-dependent nucleosome assembly (GO:0006335)3.12592413
90arachidonic acid secretion (GO:0050482)3.12171096
91icosanoid secretion (GO:0032309)3.12171096
92glycolytic process (GO:0006096)3.10087722
93branching involved in mammary gland duct morphogenesis (GO:0060444)3.10023504
94cardiovascular system development (GO:0072358)3.06457889
95sarcomere organization (GO:0045214)3.06229462
96proline transport (GO:0015824)3.05558246
97response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.05012938
98membrane depolarization during action potential (GO:0086010)3.02023730
99cell fate commitment involved in formation of primary germ layer (GO:0060795)3.01511948
100protein neddylation (GO:0045116)3.01147123
101neuromuscular synaptic transmission (GO:0007274)2.99117007
102negative regulation of calcium ion transmembrane transport (GO:1903170)2.98015474
103negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.98015474
104intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.96884694
105regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.96635993
106ubiquinone biosynthetic process (GO:0006744)2.96632971
107regulation of cell communication by electrical coupling (GO:0010649)2.96181071
108cofactor catabolic process (GO:0051187)2.96172692
109regulation of telomere maintenance (GO:0032204)2.96062164
110cofactor transport (GO:0051181)2.95754066
111thyroid hormone generation (GO:0006590)2.94991711
112melanosome transport (GO:0032402)2.93338275
113mitochondrion localization (GO:0051646)2.92405441
114phagocytosis, recognition (GO:0006910)2.91399927
115apoptotic DNA fragmentation (GO:0006309)2.91250593
116bone trabecula formation (GO:0060346)2.91147088
117pseudouridine synthesis (GO:0001522)2.90688805
118mitochondrial respiratory chain complex I assembly (GO:0032981)2.89375441
119NADH dehydrogenase complex assembly (GO:0010257)2.89375441
120mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89375441
121creatine metabolic process (GO:0006600)2.87928795
122retinoic acid receptor signaling pathway (GO:0048384)2.86364080
123nucleobase catabolic process (GO:0046113)2.86228977
124regulation of cardiac muscle cell apoptotic process (GO:0010665)2.86051561
125receptor recycling (GO:0001881)2.84930207
126protein complex biogenesis (GO:0070271)2.84576262
127positive regulation of protein homodimerization activity (GO:0090073)2.83607696
128establishment of melanosome localization (GO:0032401)2.81181406
129actin filament-based movement (GO:0030048)2.80772301
130heterochromatin organization (GO:0070828)2.79729536
131positive regulation of defense response to virus by host (GO:0002230)2.79219060
132intestinal epithelial cell development (GO:0060576)2.79047458
133DNA deamination (GO:0045006)2.78090452
134adenosine metabolic process (GO:0046085)2.77709296
135negative regulation of response to food (GO:0032096)2.76590275
136negative regulation of appetite (GO:0032099)2.76590275
137myotube cell development (GO:0014904)2.73400755
138inositol phosphate catabolic process (GO:0071545)2.72892801
139regulation of action potential (GO:0098900)2.72854717
140calcium ion import (GO:0070509)2.70978935
141positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.68255358
142neuronal action potential (GO:0019228)2.67849748
143negative regulation of protein localization to cell surface (GO:2000009)2.66288346
144gamma-aminobutyric acid transport (GO:0015812)2.66156734
145epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.65333766
146skeletal muscle fiber development (GO:0048741)2.64457998
147positive regulation of potassium ion transmembrane transport (GO:1901381)2.64139759
148ubiquinone metabolic process (GO:0006743)2.62023896
149nitric oxide mediated signal transduction (GO:0007263)2.59585919
150response to muscle activity (GO:0014850)2.59461560
151mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.59312478
152water-soluble vitamin biosynthetic process (GO:0042364)2.59087184
153regulation of female receptivity (GO:0045924)2.58730022
154muscle fiber development (GO:0048747)2.58569321
155negative regulation of heart rate (GO:0010459)2.58318127
156detection of light stimulus involved in visual perception (GO:0050908)2.55760604
157detection of light stimulus involved in sensory perception (GO:0050962)2.55760604
158regulation of actin filament-based movement (GO:1903115)2.55159387
159regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.54023849
160postsynaptic membrane organization (GO:0001941)2.53814554
161negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50726811
162pyrimidine nucleoside catabolic process (GO:0046135)2.50634691
163regulation of glucokinase activity (GO:0033131)2.50423163
164regulation of hexokinase activity (GO:1903299)2.50423163
165muscle contraction (GO:0006936)2.50072081
166pyrimidine-containing compound catabolic process (GO:0072529)2.49768491
167regulation of striated muscle contraction (GO:0006942)2.47800006
168somite development (GO:0061053)2.44934258
169regulation of sarcomere organization (GO:0060297)2.44270527
170positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.43293208
171mitochondrial respiratory chain complex assembly (GO:0033108)2.42452294
172negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.42077773
173regulation of potassium ion transmembrane transporter activity (GO:1901016)2.40090602
174C4-dicarboxylate transport (GO:0015740)2.38857323
175regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.38313634
176action potential (GO:0001508)2.37072418
177quinone biosynthetic process (GO:1901663)2.36818718
178activated T cell proliferation (GO:0050798)2.35346727
179regulation of sodium ion transmembrane transporter activity (GO:2000649)2.35153499
180positive regulation of sodium ion transmembrane transport (GO:1902307)2.33560839
181cellular ketone body metabolic process (GO:0046950)2.33141278
182muscle system process (GO:0003012)2.33012934
183adaptation of signaling pathway (GO:0023058)2.31362361
184regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.31338969
185positive regulation of mitochondrial fission (GO:0090141)2.30851091
186regulation of potassium ion transmembrane transport (GO:1901379)2.30404387
187regulation of calcium ion transmembrane transporter activity (GO:1901019)2.27129021
188regulation of calcium ion transmembrane transport (GO:1903169)2.27129021
189platelet dense granule organization (GO:0060155)2.26669151
190skeletal muscle tissue regeneration (GO:0043403)2.26261835
191negative regulation of muscle contraction (GO:0045932)2.25987501
192establishment of protein localization to mitochondrial membrane (GO:0090151)2.25779501
193daunorubicin metabolic process (GO:0044597)11.5976202
194polyketide metabolic process (GO:0030638)11.5976202
195doxorubicin metabolic process (GO:0044598)11.5976202

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.97602200
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human6.00377953
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.78026865
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.78026865
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.78026865
6EZH2_22144423_ChIP-Seq_EOC_Human5.22065841
7NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.18909829
8ZNF274_21170338_ChIP-Seq_K562_Hela2.94624006
9GBX2_23144817_ChIP-Seq_PC3_Human2.80980634
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.73754549
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.73333228
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.73273141
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69705784
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.67043706
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.62648193
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.58629721
17SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.30009889
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29220881
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.24866514
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21300884
21IRF1_19129219_ChIP-ChIP_H3396_Human2.20226493
22NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.08574998
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.08566190
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04873051
25TCF3_18692474_ChIP-Seq_MESCs_Mouse2.04135297
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.92789165
27NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.89895002
28VDR_22108803_ChIP-Seq_LS180_Human1.88622556
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80232194
30NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.79267613
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77990332
32TCF3_18692474_ChIP-Seq_MEFs_Mouse1.72977662
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71298348
34ER_23166858_ChIP-Seq_MCF-7_Human1.67322252
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.67082965
36E2F1_17053090_ChIP-ChIP_MCF-7_Human1.66501468
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64925832
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64031652
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59628628
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56598852
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54594929
42REST_21632747_ChIP-Seq_MESCs_Mouse1.54192484
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.53313718
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52528786
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50676023
46TAF15_26573619_Chip-Seq_HEK293_Human1.49310248
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48954134
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48937582
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48092422
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46851619
51P300_19829295_ChIP-Seq_ESCs_Human1.46677038
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46235478
53SMAD4_21799915_ChIP-Seq_A2780_Human1.41314234
54KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41298219
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39033847
56CBP_20019798_ChIP-Seq_JUKART_Human1.39033847
57TP53_22573176_ChIP-Seq_HFKS_Human1.37782067
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37549018
59BCAT_22108803_ChIP-Seq_LS180_Human1.36894747
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36809490
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.36351189
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36187362
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.35907187
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35071117
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35030349
66POU5F1_16518401_ChIP-PET_MESCs_Mouse1.34926184
67POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.34725132
68PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.33280984
69* REST_18959480_ChIP-ChIP_MESCs_Mouse1.32448435
70NANOG_18692474_ChIP-Seq_MESCs_Mouse1.32360790
71FUS_26573619_Chip-Seq_HEK293_Human1.32268136
72NANOG_18692474_ChIP-Seq_MEFs_Mouse1.31321529
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31231856
74* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30975266
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30685711
76* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.29687478
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27640589
78AR_25329375_ChIP-Seq_VCAP_Human1.27587888
79SOX2_19829295_ChIP-Seq_ESCs_Human1.25293883
80NANOG_19829295_ChIP-Seq_ESCs_Human1.25293883
81EWS_26573619_Chip-Seq_HEK293_Human1.24825610
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.24033452
83* HTT_18923047_ChIP-ChIP_STHdh_Human1.22643586
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.22307812
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21860348
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21666138
87SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21518339
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.21345316
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20232909
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19906541
91TCF4_23295773_ChIP-Seq_U87_Human1.19417491
92STAT3_23295773_ChIP-Seq_U87_Human1.17337923
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15238957
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14851672
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14846836
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14677509
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13309886
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12312022
99BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11390939
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10766143
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.09827967
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09662948
103KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08069467
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07947993
105* GATA3_21878914_ChIP-Seq_MCF-7_Human1.07695149
106OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07573561
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.06854729
108NCOR_22424771_ChIP-Seq_293T_Human1.06815170
109PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06800781
110ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06420661
111NANOG_16518401_ChIP-PET_MESCs_Mouse1.06081023
112SMC4_20622854_ChIP-Seq_HELA_Human1.05963216
113JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05727151
114EZH2_27294783_Chip-Seq_ESCs_Mouse1.04031987
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03766378
116JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03708827
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03621141
118PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03093996
119NANOG_20526341_ChIP-Seq_ESCs_Human1.02776928
120SMAD4_21741376_ChIP-Seq_EPCs_Human1.02468990
121NANOG_21062744_ChIP-ChIP_HESCs_Human1.02377779
122TAL1_26923725_Chip-Seq_HPCs_Mouse1.02114981
123EZH2_27304074_Chip-Seq_ESCs_Mouse1.01150112
124EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01005515
125PRDM14_20953172_ChIP-Seq_ESCs_Human1.00646685
126FOXA1_25329375_ChIP-Seq_VCAP_Human1.00358590
127FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00358590
128CRX_20693478_ChIP-Seq_RETINA_Mouse1.00254392
129EST1_17652178_ChIP-ChIP_JURKAT_Human0.99888763
130BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99759319
131NFE2_27457419_Chip-Seq_LIVER_Mouse0.99194588
132SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98982356
133AR_20517297_ChIP-Seq_VCAP_Human0.98276244
134P53_22387025_ChIP-Seq_ESCs_Mouse0.98033648
135CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96989772
136SOX2_18692474_ChIP-Seq_MESCs_Mouse0.96627824
137EOMES_21245162_ChIP-Seq_HESCs_Human0.96390266
138SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96122333
139FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95702997
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95129485
141POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95129485
142PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94988958
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94606318
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94534933
145PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94459729
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94427436
147CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93886350
148POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93597372
149DROSHA_22980978_ChIP-Seq_HELA_Human0.93282895
150EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92140591
151TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91949292
152AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91874049
153SOX2_21211035_ChIP-Seq_LN229_Gbm0.91687157
154NANOG_16153702_ChIP-ChIP_HESCs_Human0.91609337
155MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90567643
156SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89561766
157ELF1_20517297_ChIP-Seq_JURKAT_Human0.89499261
158MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89253735
159JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88474286
160SMAD3_21741376_ChIP-Seq_EPCs_Human0.88277182
161YY1_22570637_ChIP-Seq_MALME-3M_Human0.88053248
162MYC_19030024_ChIP-ChIP_MESCs_Mouse0.87826567
163* CDX2_22108803_ChIP-Seq_LS180_Human0.87500416
164SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87473144
165RNF2_27304074_Chip-Seq_NSC_Mouse0.87314869
166RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87116116
167SCL_19346495_ChIP-Seq_HPC-7_Human0.86545242
168SRF_21415370_ChIP-Seq_HL-1_Mouse0.85929213
169STAT3_18555785_ChIP-Seq_MESCs_Mouse0.84276411
170ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84031969
171PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83406326
172TP53_22127205_ChIP-Seq_IMR90_Human0.82740938
173ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.81514182
174CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80432691
175FOXP3_21729870_ChIP-Seq_TREG_Human0.79998390
176SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.77726348
177* SPI1_26923725_Chip-Seq_HPCs_Mouse0.77378717
178CTCF_21964334_Chip-Seq_Bcells_Human0.76618392
179E2F1_18555785_ChIP-Seq_MESCs_Mouse0.76157089
180* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.74131756
181TBX3_20139965_ChIP-Seq_ESCs_Mouse0.73120983
182TBX3_20139965_ChIP-Seq_MESCs_Mouse0.71931327
183POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.71847033
184THAP11_20581084_ChIP-Seq_MESCs_Mouse0.71632684
185SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70368422
186CSB_26484114_Chip-Seq_FIBROBLAST_Human0.70242745
187BCOR_27268052_Chip-Seq_Bcells_Human0.70207366
188ESET_19884257_ChIP-Seq_ESCs_Mouse0.70126572
189* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.69697830
190RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.69263262
191IGF1R_20145208_ChIP-Seq_DFB_Human0.68760482
192HOXB7_26014856_ChIP-Seq_BT474_Human0.68682146
193SOX3_22085726_ChIP-Seq_NPCs_Mouse0.68267149
194CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.68246935

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.52699164
2MP0006292_abnormal_olfactory_placode3.85767408
3MP0002332_abnormal_exercise_endurance3.69699436
4MP0004264_abnormal_extraembryonic_tissu3.56718926
5MP0000749_muscle_degeneration3.41281500
6MP0003646_muscle_fatigue3.35444858
7MP0004858_abnormal_nervous_system3.31860073
8MP0003122_maternal_imprinting3.19070533
9MP0006035_abnormal_mitochondrial_morpho3.13510012
10MP0005394_taste/olfaction_phenotype3.02909656
11MP0005499_abnormal_olfactory_system3.02909656
12MP0005075_abnormal_melanosome_morpholog2.93861571
13MP0003183_abnormal_peptide_metabolism2.62880254
14MP0002254_reproductive_system_inflammat2.56160274
15MP0002837_dystrophic_cardiac_calcinosis2.36498542
16MP0004084_abnormal_cardiac_muscle2.35197947
17MP0002127_abnormal_cardiovascular_syste2.33971502
18MP0003890_abnormal_embryonic-extraembry2.24470006
19MP0002653_abnormal_ependyma_morphology2.23603484
20MP0008057_abnormal_DNA_replication2.20057862
21MP0003121_genomic_imprinting2.17961537
22MP0004215_abnormal_myocardial_fiber2.15280922
23MP0000750_abnormal_muscle_regeneration2.15179119
24MP0006036_abnormal_mitochondrial_physio2.14903338
25MP0003137_abnormal_impulse_conducting2.08443482
26MP0002269_muscular_atrophy2.02806642
27MP0004036_abnormal_muscle_relaxation2.01120643
28MP0001986_abnormal_taste_sensitivity1.99541436
29MP0005266_abnormal_metabolism1.90835874
30MP0005330_cardiomyopathy1.80259654
31MP0002102_abnormal_ear_morphology1.79459528
32MP0000751_myopathy1.78079915
33MP0002638_abnormal_pupillary_reflex1.74461094
34MP0004957_abnormal_blastocyst_morpholog1.74033615
35MP0002822_catalepsy1.72798437
36MP0006276_abnormal_autonomic_nervous1.63841810
37MP0004087_abnormal_muscle_fiber1.62208173
38MP0005646_abnormal_pituitary_gland1.60463992
39MP0004147_increased_porphyrin_level1.59611025
40MP0002106_abnormal_muscle_physiology1.57068303
41MP0004043_abnormal_pH_regulation1.55465844
42MP0001968_abnormal_touch/_nociception1.53445962
43MP0000759_abnormal_skeletal_muscle1.52517736
44MP0005620_abnormal_muscle_contractility1.50660130
45MP0004145_abnormal_muscle_electrophysio1.49063468
46MP0005257_abnormal_intraocular_pressure1.48628819
47MP0002972_abnormal_cardiac_muscle1.47637572
48MP0000678_abnormal_parathyroid_gland1.44160027
49MP0008877_abnormal_DNA_methylation1.42976430
50MP0005645_abnormal_hypothalamus_physiol1.42338065
51MP0002272_abnormal_nervous_system1.42028986
52MP0005423_abnormal_somatic_nervous1.39443770
53MP0005551_abnormal_eye_electrophysiolog1.38222473
54MP0009745_abnormal_behavioral_response1.36997035
55MP0008872_abnormal_physiological_respon1.35769946
56MP0002876_abnormal_thyroid_physiology1.35053635
57MP0005084_abnormal_gallbladder_morpholo1.33495348
58MP0006082_CNS_inflammation1.32211954
59MP0001984_abnormal_olfaction1.31761206
60MP0005369_muscle_phenotype1.31335868
61MP0000372_irregular_coat_pigmentation1.30462551
62MP0002088_abnormal_embryonic_growth/wei1.29431283
63MP0003984_embryonic_growth_retardation1.28603723
64MP0003879_abnormal_hair_cell1.28026173
65MP0005380_embryogenesis_phenotype1.27766348
66MP0001672_abnormal_embryogenesis/_devel1.27766348
67MP0000230_abnormal_systemic_arterial1.24380301
68MP0002733_abnormal_thermal_nociception1.24299054
69MP0003938_abnormal_ear_development1.24295702
70MP0003724_increased_susceptibility_to1.22381805
71MP0004085_abnormal_heartbeat1.21450550
72MP0002277_abnormal_respiratory_mucosa1.20708641
73MP0002736_abnormal_nociception_after1.19490532
74MP0000343_altered_response_to1.18386449
75MP0001970_abnormal_pain_threshold1.17802164
76MP0001529_abnormal_vocalization1.16860296
77MP0003880_abnormal_central_pattern1.16845212
78MP0008789_abnormal_olfactory_epithelium1.16298167
79MP0002734_abnormal_mechanical_nocicepti1.15477178
80MP0003635_abnormal_synaptic_transmissio1.13537088
81MP0001905_abnormal_dopamine_level1.12084270
82MP0003221_abnormal_cardiomyocyte_apopto1.11770079
83MP0003705_abnormal_hypodermis_morpholog1.11592478
84MP0002970_abnormal_white_adipose1.09847036
85MP0010630_abnormal_cardiac_muscle1.09176166
86MP0002064_seizures1.09150609
87MP0008775_abnormal_heart_ventricle1.09028270
88MP0002735_abnormal_chemical_nociception1.06352358
89MP0005253_abnormal_eye_physiology1.04870811
90MP0004885_abnormal_endolymph1.04313694
91MP0008961_abnormal_basal_metabolism1.04105775
92MP0002067_abnormal_sensory_capabilities1.03328533
93MP0005167_abnormal_blood-brain_barrier1.03091178
94MP0001485_abnormal_pinna_reflex1.00516269
95MP0009780_abnormal_chondrocyte_physiolo1.00460697
96MP0005386_behavior/neurological_phenoty1.00436597
97MP0004924_abnormal_behavior1.00436597
98MP0000631_abnormal_neuroendocrine_gland0.99180999
99MP0003787_abnormal_imprinting0.99152629
100MP0001486_abnormal_startle_reflex0.98104235
101MP0005464_abnormal_platelet_physiology0.97136928
102MP0003123_paternal_imprinting0.95698775
103MP0002063_abnormal_learning/memory/cond0.94521242
104MP0002572_abnormal_emotion/affect_behav0.94437304
105MP0002932_abnormal_joint_morphology0.93233671
106MP0005535_abnormal_body_temperature0.92648951
107MP0001544_abnormal_cardiovascular_syste0.90861413
108MP0005385_cardiovascular_system_phenoty0.90861413
109MP0001348_abnormal_lacrimal_gland0.89517847
110MP0004484_altered_response_of0.88394564
111MP0003828_pulmonary_edema0.88337215
112MP0010386_abnormal_urinary_bladder0.87694587
113MP0006138_congestive_heart_failure0.87399671
114MP0000013_abnormal_adipose_tissue0.87352540
115MP0002163_abnormal_gland_morphology0.86599067
116MP0004510_myositis0.85828688
117MP0000358_abnormal_cell_content/0.85421871
118MP0010030_abnormal_orbit_morphology0.82893848
119MP0003950_abnormal_plasma_membrane0.82518953
120MP0005083_abnormal_biliary_tract0.82336273
121MP0002396_abnormal_hematopoietic_system0.81583754
122MP0002078_abnormal_glucose_homeostasis0.80919495
123MP0003195_calcinosis0.79895515
124MP0000762_abnormal_tongue_morphology0.78427025
125MP0002138_abnormal_hepatobiliary_system0.77321146
126MP0004859_abnormal_synaptic_plasticity0.75544701
127MP0005379_endocrine/exocrine_gland_phen0.74548873
128MP0005410_abnormal_fertilization0.73186148
129MP0001849_ear_inflammation0.73180810
130MP0000049_abnormal_middle_ear0.73101649
131MP0002114_abnormal_axial_skeleton0.72920936
132MP0002557_abnormal_social/conspecific_i0.72654593
133MP0005319_abnormal_enzyme/_coenzyme0.72212702
134MP0005376_homeostasis/metabolism_phenot0.70799734
135MP0006072_abnormal_retinal_apoptosis0.70421868
136MP0003806_abnormal_nucleotide_metabolis0.70033852
137MP0000747_muscle_weakness0.69413506
138MP0000350_abnormal_cell_proliferation0.69092541
139MP0002693_abnormal_pancreas_physiology0.67209244
140MP0001293_anophthalmia0.65748317
141MP0009046_muscle_twitch0.64073859
142MP0002085_abnormal_embryonic_tissue0.64046198
143MP0002132_abnormal_respiratory_system0.62975671
144MP0004130_abnormal_muscle_cell0.61987832
145MP0000266_abnormal_heart_morphology0.61853275
146MP0008770_decreased_survivor_rate0.58873320
147MP0002086_abnormal_extraembryonic_tissu0.58527530
148MP0002233_abnormal_nose_morphology0.57910260
149MP0005452_abnormal_adipose_tissue0.57598975
150MP0004142_abnormal_muscle_tone0.55261216
151MP0003077_abnormal_cell_cycle0.55206863
152MP0004270_analgesia0.54965146
153MP0000313_abnormal_cell_death0.54023721
154MP0009115_abnormal_fat_cell0.51251036
155MP0002909_abnormal_adrenal_gland0.50120689
156MP0002925_abnormal_cardiovascular_devel0.49337592
157MP0003186_abnormal_redox_activity0.48627001
158MP0002752_abnormal_somatic_nervous0.47763418
159MP0000428_abnormal_craniofacial_morphol0.46085962

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.58715515
2Nemaline bodies (HP:0003798)6.53651220
3Bilateral microphthalmos (HP:0007633)6.53526346
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.24513415
5Hypochromic microcytic anemia (HP:0004840)5.76583072
6Multiple enchondromatosis (HP:0005701)5.22015532
7Exercise-induced muscle cramps (HP:0003710)4.75721730
8Hepatoblastoma (HP:0002884)4.74267869
9Abnormality of the lower motor neuron (HP:0002366)4.29967044
10Ragged-red muscle fibers (HP:0003200)4.27885971
11Type 1 muscle fiber predominance (HP:0003803)4.16566941
12Increased serum pyruvate (HP:0003542)3.97495307
13Abnormality of glycolysis (HP:0004366)3.97495307
14Hyperventilation (HP:0002883)3.84144699
15Rib fusion (HP:0000902)3.69456520
16Hypoplasia of the fovea (HP:0007750)3.67664911
17Aplasia/Hypoplasia of the fovea (HP:0008060)3.67664911
18Difficulty running (HP:0009046)3.62246851
19Testicular atrophy (HP:0000029)3.51175800
20Distal arthrogryposis (HP:0005684)3.47251573
21Ventricular tachycardia (HP:0004756)3.47051405
22Increased connective tissue (HP:0009025)3.23875627
23Hyperinsulinemic hypoglycemia (HP:0000825)3.22066060
24Ependymoma (HP:0002888)3.05596475
25Rimmed vacuoles (HP:0003805)3.04993340
26Nephroblastoma (Wilms tumor) (HP:0002667)2.99354338
27Abnormality of the fovea (HP:0000493)2.99139352
283-Methylglutaconic aciduria (HP:0003535)2.96575741
29Exercise-induced myalgia (HP:0003738)2.86456427
30Fetal akinesia sequence (HP:0001989)2.85794266
31Progressive muscle weakness (HP:0003323)2.84364248
32Neoplasm of striated muscle (HP:0009728)2.83170674
33Embryonal renal neoplasm (HP:0011794)2.81452145
34Bifid tongue (HP:0010297)2.81258207
35Abnormality of the salivary glands (HP:0010286)2.78838690
36Myopathic facies (HP:0002058)2.78713766
37Myoglobinuria (HP:0002913)2.74575833
38Absent phalangeal crease (HP:0006109)2.70395731
39EMG: myopathic abnormalities (HP:0003458)2.67461456
40Rhabdomyosarcoma (HP:0002859)2.67027384
41Acute necrotizing encephalopathy (HP:0006965)2.63437576
42Horizontal nystagmus (HP:0000666)2.63397505
43Rectovaginal fistula (HP:0000143)2.55820120
44Rectal fistula (HP:0100590)2.55820120
45Ulnar deviation of the wrist (HP:0003049)2.55242165
46Generalized hypotonia (HP:0001290)2.55240193
47Anomalous pulmonary venous return (HP:0010772)2.54031030
48Type 2 muscle fiber atrophy (HP:0003554)2.53122827
49Amyotrophic lateral sclerosis (HP:0007354)2.52900741
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.50207005
51Frequent falls (HP:0002359)2.49050882
52Bundle branch block (HP:0011710)2.48849629
53Partial duplication of thumb phalanx (HP:0009944)2.46213860
54Abnormal cartilage morphology (HP:0002763)2.46200929
55Progressive macrocephaly (HP:0004481)2.46129538
56Reduced antithrombin III activity (HP:0001976)2.44627090
57Abnormality of chromosome segregation (HP:0002916)2.42551293
58Abnormal lung lobation (HP:0002101)2.41650586
59Pancreatic cysts (HP:0001737)2.40705590
60Hyporeflexia of lower limbs (HP:0002600)2.40590756
61Mitochondrial inheritance (HP:0001427)2.40129522
62Periauricular skin pits (HP:0100277)2.39591255
63Preauricular pit (HP:0004467)2.39591255
64Abnormal mitochondria in muscle tissue (HP:0008316)2.38322995
65Atrial fibrillation (HP:0005110)2.37763439
66Muscle fibrillation (HP:0010546)2.35966645
67Abnormal finger flexion creases (HP:0006143)2.34607842
68Neck muscle weakness (HP:0000467)2.34443801
69Subaortic stenosis (HP:0001682)2.34338005
70Abnormality of the left ventricular outflow tract (HP:0011103)2.34338005
71Progressive external ophthalmoplegia (HP:0000590)2.33063821
72Congenital stationary night blindness (HP:0007642)2.31670059
73Tongue fasciculations (HP:0001308)2.30809431
74Intestinal fistula (HP:0100819)2.29688154
75Abnormality of glycosphingolipid metabolism (HP:0004343)2.29594716
76Abnormality of glycolipid metabolism (HP:0010969)2.29594716
77Abnormality of liposaccharide metabolism (HP:0010968)2.29594716
78Primary atrial arrhythmia (HP:0001692)2.28499985
79Microvesicular hepatic steatosis (HP:0001414)2.28133038
80Hepatic necrosis (HP:0002605)2.27948529
81Medial flaring of the eyebrow (HP:0010747)2.27718236
82Sudden death (HP:0001699)2.27660562
83Round ear (HP:0100830)2.27059811
84Febrile seizures (HP:0002373)2.26081971
85Ketoacidosis (HP:0001993)2.25893616
86Failure to thrive in infancy (HP:0001531)2.23239724
87Supraventricular tachycardia (HP:0004755)2.22845780
88Sensory axonal neuropathy (HP:0003390)2.21886671
89Molar tooth sign on MRI (HP:0002419)2.21350910
90Abnormality of midbrain morphology (HP:0002418)2.21350910
91Gout (HP:0001997)2.21265475
92Nasolacrimal duct obstruction (HP:0000579)2.19829055
93Nephronophthisis (HP:0000090)2.19267557
94Fused cervical vertebrae (HP:0002949)2.19125652
95Tetraplegia (HP:0002445)2.18988087
96EMG: neuropathic changes (HP:0003445)2.18817686
97Pancreatic fibrosis (HP:0100732)2.18139434
98Muscle hypertrophy of the lower extremities (HP:0008968)2.16297902
99Fatigable weakness (HP:0003473)2.15995990
100Abnormality of the neuromuscular junction (HP:0003398)2.15995990
101Aplasia/Hypoplasia of the macula (HP:0008059)2.15749844
102Acute encephalopathy (HP:0006846)2.15739387
103Type II lissencephaly (HP:0007260)2.15141127
104Abnormality of the renal cortex (HP:0011035)2.15013830
105Vaginal fistula (HP:0004320)2.14762685
106Calf muscle hypertrophy (HP:0008981)2.14037918
107Renal cortical cysts (HP:0000803)2.13611362
108Chromsome breakage (HP:0040012)2.12745836
109Supraventricular arrhythmia (HP:0005115)2.11855544
110Increased CSF lactate (HP:0002490)2.11426785
111Hepatocellular necrosis (HP:0001404)2.11267646
112Combined immunodeficiency (HP:0005387)2.10735757
113Abnormality of the pubic bones (HP:0003172)2.10254692
114Abnormality of the pulmonary veins (HP:0011718)2.07382150
115Myotonia (HP:0002486)2.05680110
116Hypochromic anemia (HP:0001931)2.04277042
117Epileptic encephalopathy (HP:0200134)2.02785687
118Ketosis (HP:0001946)2.02293769
119Muscle fiber atrophy (HP:0100295)2.02175535
120True hermaphroditism (HP:0010459)2.02137050
121Partial duplication of the phalanx of hand (HP:0009999)2.01539854
122Rhabdomyolysis (HP:0003201)2.00426250
123Weak cry (HP:0001612)2.00118776
124Neoplasm of the heart (HP:0100544)1.99697899
125Muscle fiber splitting (HP:0003555)1.99567859
126Trismus (HP:0000211)1.99223047
127Methylmalonic acidemia (HP:0002912)1.97960107
128Hemiparesis (HP:0001269)1.97802972
129Aplasia/Hypoplasia affecting the retina (HP:0008061)1.97733483
130Inability to walk (HP:0002540)1.97417301
131Increased variability in muscle fiber diameter (HP:0003557)1.96399445
132Muscle stiffness (HP:0003552)1.96381940
133Skin nodule (HP:0200036)1.95610957
134Absent speech (HP:0001344)1.94946229
135Polyphagia (HP:0002591)1.94628577
136Abnormality of the phalanges of the hallux (HP:0010057)1.94173169
137Mildly elevated creatine phosphokinase (HP:0008180)1.94114426
138Generalized muscle weakness (HP:0003324)1.93504604
139Astrocytoma (HP:0009592)1.92932486
140Abnormality of the astrocytes (HP:0100707)1.92932486
141Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92827064
142Syncope (HP:0001279)1.92671803
143Left ventricular hypertrophy (HP:0001712)1.91594117
144Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91427911
145Abnormality of alanine metabolism (HP:0010916)1.91427911
146Hyperalaninemia (HP:0003348)1.91427911
147Malignant hyperthermia (HP:0002047)1.88090712
148Gait imbalance (HP:0002141)1.87379714
149Agitation (HP:0000713)1.87144039
150Pachygyria (HP:0001302)1.86518276
151Abnormal EKG (HP:0003115)1.86349200
152Exercise intolerance (HP:0003546)1.86340362
153Angiofibromas (HP:0010615)1.86071853
154Adenoma sebaceum (HP:0009720)1.86071853
155Dyschromatopsia (HP:0007641)1.85845224
156Amblyopia (HP:0000646)1.84197441
157Increased intramyocellular lipid droplets (HP:0012240)1.83426556
158Stomatitis (HP:0010280)1.83028572
159Abnormality of skeletal muscle fiber size (HP:0012084)1.82495354
160Webbed neck (HP:0000465)1.82272169
161Optic disc pallor (HP:0000543)1.81836027
162Abnormality of the renal medulla (HP:0100957)1.81749812
163Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81058422
164Abnormality of the calf musculature (HP:0001430)1.80911590
165Shawl scrotum (HP:0000049)1.80727106
166Attenuation of retinal blood vessels (HP:0007843)1.80596106
167Gowers sign (HP:0003391)1.79917004
168Methylmalonic aciduria (HP:0012120)1.75448827
169Ventricular fibrillation (HP:0001663)1.74862367
170Prolonged QT interval (HP:0001657)1.74423815
171Progressive cerebellar ataxia (HP:0002073)1.73593116
172Oligomenorrhea (HP:0000876)1.72614627
173Paralysis (HP:0003470)1.71161201
174Broad-based gait (HP:0002136)1.69879871
175Lactic acidosis (HP:0003128)1.69479289
176Abnormal rod and cone electroretinograms (HP:0008323)1.68737239
177Congenital primary aphakia (HP:0007707)1.68272731
178Increased muscle lipid content (HP:0009058)1.68227594
179Poor eye contact (HP:0000817)1.65962677
180Congenital sensorineural hearing impairment (HP:0008527)1.63022860
181Areflexia of lower limbs (HP:0002522)1.62553643
182Absent rod-and cone-mediated responses on ERG (HP:0007688)1.60236467

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.75847076
2GRK55.61918131
3ERN14.14083383
4GRK64.02331729
5ADRBK23.36035364
6FRK3.17776844
7GRK73.16453862
8GRK13.10651786
9CSF1R2.96877998
10TGFBR22.63791166
11BMPR1B2.49456291
12MAPK72.37740388
13MARK12.32127501
14MOS2.31485071
15TYRO32.18036252
16MAP4K22.06159068
17MATK2.05795166
18MAPK132.04415315
19PIK3CG1.96509586
20TTK1.93915858
21NEK11.93602183
22TAOK31.86121982
23MAP2K41.83613209
24WNK31.80795159
25WNK11.76346020
26OBSCN1.67986484
27CAMK41.66772825
28STK101.65191705
29PDK31.63809259
30PDK41.63809259
31DAPK21.58889918
32PRKG21.57526965
33PHKG11.44686685
34PHKG21.44686685
35ADRBK11.39119878
36TXK1.34613953
37MAPK121.31891470
38MARK21.25390307
39AKT31.22132806
40TTN1.15564605
41NTRK11.09305272
42PTK2B1.09288028
43ACVR1B1.08388349
44TRIM281.05949232
45EPHA31.00204744
46MAP3K70.97458837
47CAMKK20.93321110
48RIPK40.91800649
49PRPF4B0.91351647
50MST40.90423699
51CDK80.89609084
52MAP2K60.89596853
53LATS20.85861603
54NUAK10.85313955
55CSNK1G20.85118006
56CHEK20.83257314
57TNK20.82909634
58CDK70.82865644
59PDK20.81211082
60CAMK10.80918144
61OXSR10.80448786
62SYK0.78402954
63FGFR30.76739536
64PAK40.76535192
65PINK10.76516951
66CSNK1G30.74509785
67PLK20.74303340
68PKN10.72139791
69ERBB30.71879312
70HIPK20.70020205
71CAMK2A0.69866483
72SGK20.68624809
73AKT20.67318665
74TEC0.67252550
75CSNK1G10.67055655
76PLK10.66675341
77WNK40.62326083
78CAMK2D0.61560913
79TRPM70.60879041
80SGK4940.60735923
81SGK2230.60735923
82INSRR0.60379298
83PIK3CA0.58083702
84PRKAA10.57878803
85PRKCE0.57694065
86MUSK0.57637838
87PRKG10.57611252
88PAK30.56674423
89TLK10.54691573
90MAPKAPK30.54454183
91CAMK2G0.53852013
92MAP2K70.52479085
93MYLK0.51674459
94SGK30.51519362
95LMTK20.50151482
96SIK30.49534205
97CSNK1A1L0.49532185
98STK380.49353132
99TNIK0.48313741
100KIT0.47860742
101PRKCQ0.47417200
102DYRK1B0.46722731
103ZAK0.46230428
104CDK50.46093761
105BTK0.45720296
106BCKDK0.45626477
107CCNB10.45200909
108TAOK10.44820678
109PRKCZ0.44503370
110NTRK20.44194851
111CASK0.42316377
112MARK30.41844961
113STK38L0.40934407
114LIMK10.40716685
115FES0.40354673
116NTRK30.38995712
117CAMK2B0.38727825
118STK110.38586293
119STK390.37862564
120SGK10.37371916
121PRKCD0.37024079
122MAP2K30.36434372
123DYRK20.36273584
124CDC70.36092554
125MAP3K110.35516456
126CDK190.34774570
127LYN0.34704178
128IRAK10.34404934
129TAOK20.34321600
130CHEK10.33728994
131MAP3K90.33024934
132PRKACB0.32355724
133MAP3K40.32273847
134IGF1R0.31079979
135CDK180.30933266
136CDK150.29814786
137PRKCG0.28901316
138PAK60.28777615
139ITK0.28564372
140RIPK10.26769499
141MAP3K60.26356926
142PRKACA0.25962447
143CSK0.24397353
144EIF2AK20.23301364
145STK160.22972584
146CDK140.22097386
147PRKACG0.22083794
148CDK11A0.21929644
149PRKD20.20785262
150TRIB30.20414103
151STK240.20354132
152AURKA0.18540269
153ARAF0.18512193
154MAPK40.18080719
155MAP3K120.17186947
156PAK10.16864496
157NME10.15636123
158BRAF0.12052589
159ERBB40.11881815
160MAPK100.11457975
161CDK20.09679267
162PDK10.09586523
163PRKAA20.09572196
164RPS6KA30.08003350

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.34281680
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.15275905
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.45209658
4Fructose and mannose metabolism_Homo sapiens_hsa000514.04290899
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.23745223
6Galactose metabolism_Homo sapiens_hsa000522.81687497
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32221002
8Carbon metabolism_Homo sapiens_hsa012002.25624814
9Arachidonic acid metabolism_Homo sapiens_hsa005902.22791100
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.19835956
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.17673008
12Cardiac muscle contraction_Homo sapiens_hsa042602.16987144
13Phototransduction_Homo sapiens_hsa047442.13058710
14Circadian rhythm_Homo sapiens_hsa047101.99217564
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93065160
16Linoleic acid metabolism_Homo sapiens_hsa005911.89775403
17Nitrogen metabolism_Homo sapiens_hsa009101.89051757
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.83167694
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.75494236
20Nicotine addiction_Homo sapiens_hsa050331.74153714
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71641782
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.67714515
23Circadian entrainment_Homo sapiens_hsa047131.64969593
24Morphine addiction_Homo sapiens_hsa050321.57923881
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56229873
26Parkinsons disease_Homo sapiens_hsa050121.55102521
27Dilated cardiomyopathy_Homo sapiens_hsa054141.54521460
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52355049
29Biosynthesis of amino acids_Homo sapiens_hsa012301.49825924
30Insulin secretion_Homo sapiens_hsa049111.49694312
31Oxidative phosphorylation_Homo sapiens_hsa001901.48087438
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.46926014
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45489190
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45442009
35Pyruvate metabolism_Homo sapiens_hsa006201.44707253
36Propanoate metabolism_Homo sapiens_hsa006401.42616612
37Peroxisome_Homo sapiens_hsa041461.41337790
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36246222
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33777215
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31397035
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28000662
42Protein export_Homo sapiens_hsa030601.26963898
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23201824
44Sulfur metabolism_Homo sapiens_hsa009201.21732553
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17140085
46Pentose phosphate pathway_Homo sapiens_hsa000301.15971795
47Dopaminergic synapse_Homo sapiens_hsa047281.15181095
48Thyroid cancer_Homo sapiens_hsa052161.14219174
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07962456
50Renin secretion_Homo sapiens_hsa049241.05012580
51Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04354469
52Other glycan degradation_Homo sapiens_hsa005111.04157143
53Ovarian steroidogenesis_Homo sapiens_hsa049131.03407066
54Olfactory transduction_Homo sapiens_hsa047401.02089116
55mTOR signaling pathway_Homo sapiens_hsa041500.99125706
56RNA degradation_Homo sapiens_hsa030180.96413779
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95861057
58Cholinergic synapse_Homo sapiens_hsa047250.94683933
59Regulation of autophagy_Homo sapiens_hsa041400.93001176
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92746049
61Huntingtons disease_Homo sapiens_hsa050160.92161155
62Alzheimers disease_Homo sapiens_hsa050100.90537311
63Salivary secretion_Homo sapiens_hsa049700.89435792
64Gastric acid secretion_Homo sapiens_hsa049710.86232044
65Amphetamine addiction_Homo sapiens_hsa050310.86144837
66Ether lipid metabolism_Homo sapiens_hsa005650.85485917
67Long-term depression_Homo sapiens_hsa047300.83511459
68Fatty acid degradation_Homo sapiens_hsa000710.82857213
69beta-Alanine metabolism_Homo sapiens_hsa004100.81867771
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.81537605
71Platelet activation_Homo sapiens_hsa046110.79536614
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78464357
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76968389
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76372395
75Inositol phosphate metabolism_Homo sapiens_hsa005620.74814369
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74806671
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74136501
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73647454
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.73634044
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72787242
81Taste transduction_Homo sapiens_hsa047420.72665932
82Tryptophan metabolism_Homo sapiens_hsa003800.72614392
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71819779
84Arginine and proline metabolism_Homo sapiens_hsa003300.70525372
85Cell cycle_Homo sapiens_hsa041100.69958806
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69908606
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68677515
88Caffeine metabolism_Homo sapiens_hsa002320.67670939
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66180214
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.64255410
91AMPK signaling pathway_Homo sapiens_hsa041520.62270419
92Starch and sucrose metabolism_Homo sapiens_hsa005000.61878286
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61403486
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.61327370
95Fatty acid elongation_Homo sapiens_hsa000620.60602619
96Type II diabetes mellitus_Homo sapiens_hsa049300.59254756
97Serotonergic synapse_Homo sapiens_hsa047260.58815269
98Calcium signaling pathway_Homo sapiens_hsa040200.57740066
99Fatty acid metabolism_Homo sapiens_hsa012120.57399193
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57195012
101RNA transport_Homo sapiens_hsa030130.55950713
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55490603
103Metabolic pathways_Homo sapiens_hsa011000.53260471
104GABAergic synapse_Homo sapiens_hsa047270.52856678
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52787935
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.52779551
107Cocaine addiction_Homo sapiens_hsa050300.52718228
108Pancreatic secretion_Homo sapiens_hsa049720.51775480
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48432776
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.45146887
111Primary immunodeficiency_Homo sapiens_hsa053400.44914966
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44733929
113Type I diabetes mellitus_Homo sapiens_hsa049400.44456431
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43192881
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.42354685
116Purine metabolism_Homo sapiens_hsa002300.40743608
117Synaptic vesicle cycle_Homo sapiens_hsa047210.39205537
118Choline metabolism in cancer_Homo sapiens_hsa052310.38487051
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37209720
120ABC transporters_Homo sapiens_hsa020100.36082769
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35361013
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.34938839
123Sulfur relay system_Homo sapiens_hsa041220.33519211
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.32343981
125Oxytocin signaling pathway_Homo sapiens_hsa049210.30934111
126Chemical carcinogenesis_Homo sapiens_hsa052040.30495767
127Butanoate metabolism_Homo sapiens_hsa006500.30464984
128mRNA surveillance pathway_Homo sapiens_hsa030150.30358785
129Ras signaling pathway_Homo sapiens_hsa040140.30232620
130Glutamatergic synapse_Homo sapiens_hsa047240.29634169
131Acute myeloid leukemia_Homo sapiens_hsa052210.28500753
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28432854
133Folate biosynthesis_Homo sapiens_hsa007900.27796628
134Glycerolipid metabolism_Homo sapiens_hsa005610.24302869
135Collecting duct acid secretion_Homo sapiens_hsa049660.23885121
136Rap1 signaling pathway_Homo sapiens_hsa040150.23875523
137PPAR signaling pathway_Homo sapiens_hsa033200.22513231
138GnRH signaling pathway_Homo sapiens_hsa049120.22315399
139Non-small cell lung cancer_Homo sapiens_hsa052230.21014818
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20497932
141Fanconi anemia pathway_Homo sapiens_hsa034600.19262388
142Insulin resistance_Homo sapiens_hsa049310.18415868
143Glucagon signaling pathway_Homo sapiens_hsa049220.18269910
144Pathways in cancer_Homo sapiens_hsa052000.17903220
145Basal transcription factors_Homo sapiens_hsa030220.17406749
146cAMP signaling pathway_Homo sapiens_hsa040240.17239019
147VEGF signaling pathway_Homo sapiens_hsa043700.16053001
148Glycosaminoglycan degradation_Homo sapiens_hsa005310.15948185
149Insulin signaling pathway_Homo sapiens_hsa049100.15755496

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