ASCC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1UTP biosynthetic process (GO:0006228)9.95371867
2UTP metabolic process (GO:0046051)9.12553734
3axonemal dynein complex assembly (GO:0070286)9.12233718
4nucleoside diphosphate phosphorylation (GO:0006165)9.10709473
5epithelial cilium movement (GO:0003351)8.34985686
6cilium or flagellum-dependent cell motility (GO:0001539)8.29574307
7guanosine-containing compound biosynthetic process (GO:1901070)8.21949651
8CTP biosynthetic process (GO:0006241)8.21013321
9CTP metabolic process (GO:0046036)8.21013321
10pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)7.64058776
11pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)7.16402245
12pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)6.86935282
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.51565335
14pyrimidine nucleoside triphosphate metabolic process (GO:0009147)6.38922701
15pyrimidine ribonucleoside biosynthetic process (GO:0046132)5.42891488
16ventricular system development (GO:0021591)5.42464324
17intraciliary transport (GO:0042073)5.22337843
18nucleoside diphosphate metabolic process (GO:0009132)5.19926349
19nucleotide phosphorylation (GO:0046939)5.13708227
20pyrimidine ribonucleotide biosynthetic process (GO:0009220)5.06463373
21left/right axis specification (GO:0070986)4.98487170
22purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.76084282
23ribosomal small subunit assembly (GO:0000028)4.75624672
24purine nucleoside triphosphate biosynthetic process (GO:0009145)4.66567046
25pyrimidine ribonucleotide metabolic process (GO:0009218)4.55918800
26motile cilium assembly (GO:0044458)4.52173918
27pyrimidine nucleotide biosynthetic process (GO:0006221)4.51395399
28pyrimidine nucleoside biosynthetic process (GO:0046134)4.40647105
29ribonucleoside triphosphate biosynthetic process (GO:0009201)4.38045579
30pyrimidine ribonucleoside metabolic process (GO:0046131)4.29581477
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.27018035
32cilium organization (GO:0044782)4.16831964
33nucleoside triphosphate biosynthetic process (GO:0009142)4.13394960
34microtubule bundle formation (GO:0001578)4.01590340
35ATP synthesis coupled proton transport (GO:0015986)3.95097945
36energy coupled proton transport, down electrochemical gradient (GO:0015985)3.95097945
37behavioral response to nicotine (GO:0035095)3.91814946
38regulation of cilium movement (GO:0003352)3.84200155
39pyrimidine-containing compound biosynthetic process (GO:0072528)3.81637925
40viral transcription (GO:0019083)3.80890344
41deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.79658312
42cilium assembly (GO:0042384)3.79007685
43ADP metabolic process (GO:0046031)3.72274908
44purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.70288809
45one-carbon compound transport (GO:0019755)3.68797893
46translational termination (GO:0006415)3.65723580
47aminoglycoside antibiotic metabolic process (GO:0030647)3.58571933
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.58265570
49mitochondrial respiratory chain complex assembly (GO:0033108)3.57255985
50SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.56452432
51cotranslational protein targeting to membrane (GO:0006613)3.56213083
52pyrimidine nucleotide metabolic process (GO:0006220)3.55994519
53deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.52838594
54protein targeting to ER (GO:0045047)3.50835755
55protein-cofactor linkage (GO:0018065)3.39782857
56ribosomal small subunit biogenesis (GO:0042274)3.37458743
57cilium morphogenesis (GO:0060271)3.35313116
58respiratory chain complex IV assembly (GO:0008535)3.34162181
59detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.33949164
60daunorubicin metabolic process (GO:0044597)3.32335138
61polyketide metabolic process (GO:0030638)3.32335138
62doxorubicin metabolic process (GO:0044598)3.32335138
63establishment of protein localization to endoplasmic reticulum (GO:0072599)3.29248019
64translational elongation (GO:0006414)3.29234873
65protein localization to endoplasmic reticulum (GO:0070972)3.28604733
66neural tube formation (GO:0001841)3.25463001
67maturation of SSU-rRNA (GO:0030490)3.23541600
68platelet dense granule organization (GO:0060155)3.22972922
69inner mitochondrial membrane organization (GO:0007007)3.20477558
70pyrimidine nucleoside metabolic process (GO:0006213)3.19581542
71indole-containing compound catabolic process (GO:0042436)3.16602132
72indolalkylamine catabolic process (GO:0046218)3.16602132
73tryptophan catabolic process (GO:0006569)3.16602132
74nonmotile primary cilium assembly (GO:0035058)3.14197207
75cellular component assembly involved in morphogenesis (GO:0010927)3.12110667
76mitochondrial respiratory chain complex I assembly (GO:0032981)3.06802104
77NADH dehydrogenase complex assembly (GO:0010257)3.06802104
78mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.06802104
79indolalkylamine metabolic process (GO:0006586)3.06723334
80mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.05986705
81kynurenine metabolic process (GO:0070189)3.04489599
82regulation of glucose import in response to insulin stimulus (GO:2001273)3.03239907
83positive regulation of respiratory burst (GO:0060267)3.00907524
84cytochrome complex assembly (GO:0017004)2.99522715
85regulation of mitotic spindle checkpoint (GO:1903504)2.98582597
86regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98582597
87DNA replication initiation (GO:0006270)2.98522481
88ATP biosynthetic process (GO:0006754)2.98325637
89intra-S DNA damage checkpoint (GO:0031573)2.92295935
90rRNA modification (GO:0000154)2.91726246
91purine ribonucleoside diphosphate metabolic process (GO:0009179)2.91338343
92purine nucleoside diphosphate metabolic process (GO:0009135)2.91338343
93photoreceptor cell maintenance (GO:0045494)2.91132802
94electron transport chain (GO:0022900)2.90472410
95respiratory electron transport chain (GO:0022904)2.89830437
96chromatin remodeling at centromere (GO:0031055)2.88487988
97proteasome assembly (GO:0043248)2.87144166
98nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85823970
99cellular response to nicotine (GO:0071316)2.85011666
100CENP-A containing nucleosome assembly (GO:0034080)2.84942375
101L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.84716433
102multicellular organismal aging (GO:0010259)2.84267066
103negative regulation of transcription regulatory region DNA binding (GO:2000678)2.83375012
104cellular protein complex disassembly (GO:0043624)2.82694823
105signal peptide processing (GO:0006465)2.81728656
106tryptophan metabolic process (GO:0006568)2.80836265
107protein neddylation (GO:0045116)2.80738523
108viral life cycle (GO:0019058)2.80688083
109resolution of meiotic recombination intermediates (GO:0000712)2.80643786
110anterograde synaptic vesicle transport (GO:0048490)2.80463042
111synapsis (GO:0007129)2.79968150
112water-soluble vitamin biosynthetic process (GO:0042364)2.79671406
113tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79092643
114RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79092643
115microtubule-based movement (GO:0007018)2.78903986
116oxidative phosphorylation (GO:0006119)2.77490768
117AMP metabolic process (GO:0046033)2.77402654
118response to pheromone (GO:0019236)2.76590395
119rRNA methylation (GO:0031167)2.75825897
120oxygen transport (GO:0015671)2.74970320
121nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.74423202
122mannosylation (GO:0097502)2.72308796
123replication fork processing (GO:0031297)2.71643170
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71591817
125recombinational repair (GO:0000725)2.70828718
126cullin deneddylation (GO:0010388)2.70702064
127purine nucleoside biosynthetic process (GO:0042451)2.70507737
128purine ribonucleoside biosynthetic process (GO:0046129)2.70507737
129double-strand break repair via homologous recombination (GO:0000724)2.68968002
130cellular ketone body metabolic process (GO:0046950)2.68791984
131centriole replication (GO:0007099)2.68635375
132pseudouridine synthesis (GO:0001522)2.68374957
133DNA double-strand break processing (GO:0000729)2.66991134
134organelle disassembly (GO:1903008)2.66372482
135purine deoxyribonucleotide metabolic process (GO:0009151)2.65345542
136ribonucleoside diphosphate metabolic process (GO:0009185)2.63780344
137reciprocal DNA recombination (GO:0035825)2.60765957
138reciprocal meiotic recombination (GO:0007131)2.60765957
139binding of sperm to zona pellucida (GO:0007339)2.59432196
140tachykinin receptor signaling pathway (GO:0007217)2.59346300
141cell projection assembly (GO:0030031)2.59233741
142negative regulation of translation, ncRNA-mediated (GO:0040033)2.58720568
143regulation of translation, ncRNA-mediated (GO:0045974)2.58720568
144negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.58720568
145meiotic cell cycle (GO:0051321)2.58458078
146regulation of macrophage chemotaxis (GO:0010758)2.57009275
147preassembly of GPI anchor in ER membrane (GO:0016254)2.56914051
148histone exchange (GO:0043486)2.56092124
149protein complex biogenesis (GO:0070271)2.56027836
150ribosomal large subunit biogenesis (GO:0042273)2.55855551
151transmission of nerve impulse (GO:0019226)2.53886110
152L-methionine salvage (GO:0071267)2.53705884
153L-methionine biosynthetic process (GO:0071265)2.53705884
154amino acid salvage (GO:0043102)2.53705884
155DNA damage response, detection of DNA damage (GO:0042769)2.51520159
156transcription elongation from RNA polymerase III promoter (GO:0006385)2.50967237
157termination of RNA polymerase III transcription (GO:0006386)2.50967237
158negative regulation of DNA-dependent DNA replication (GO:2000104)2.50276902
159DNA deamination (GO:0045006)2.48702197
160G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.48374567
161gamma-aminobutyric acid transport (GO:0015812)2.45540098
162reflex (GO:0060004)2.45158365
163protein deneddylation (GO:0000338)2.43632313
164ketone body metabolic process (GO:1902224)2.39844113
165anterograde axon cargo transport (GO:0008089)2.39004943
166L-fucose catabolic process (GO:0042355)2.38975567
167fucose catabolic process (GO:0019317)2.38975567
168L-fucose metabolic process (GO:0042354)2.38975567
169regulation of posttranscriptional gene silencing (GO:0060147)2.38705230
170regulation of gene silencing by miRNA (GO:0060964)2.38705230
171regulation of gene silencing by RNA (GO:0060966)2.38705230
172regulation of mitochondrial translation (GO:0070129)2.38422283
173protein polyglutamylation (GO:0018095)2.37243792
174piRNA metabolic process (GO:0034587)2.36513476
175detection of light stimulus involved in sensory perception (GO:0050962)2.35911430
176detection of light stimulus involved in visual perception (GO:0050908)2.35911430
177tRNA processing (GO:0008033)2.34944704
178cilium movement (GO:0003341)11.2303571
179GTP biosynthetic process (GO:0006183)10.9823953
180axoneme assembly (GO:0035082)10.2125887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse6.24824689
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human6.19224239
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.09962063
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.59309057
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45890205
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.37668736
7E2F7_22180533_ChIP-Seq_HELA_Human3.29832927
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.25367404
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.18016590
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.16673204
11ZNF274_21170338_ChIP-Seq_K562_Hela3.13256436
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.99358776
13VDR_22108803_ChIP-Seq_LS180_Human2.95991527
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.88675954
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.79864347
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.78623581
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.73949139
18IGF1R_20145208_ChIP-Seq_DFB_Human2.67250110
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65041343
20GBX2_23144817_ChIP-Seq_PC3_Human2.54310388
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.48107412
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.48041170
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47231544
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44984661
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41031204
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36087543
27EWS_26573619_Chip-Seq_HEK293_Human2.34774952
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.33589385
29FUS_26573619_Chip-Seq_HEK293_Human2.32329743
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28475838
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.25897206
32CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24726716
33ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.21868084
34TAF15_26573619_Chip-Seq_HEK293_Human2.18366308
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18034692
36VDR_23849224_ChIP-Seq_CD4+_Human2.17905080
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.16893934
38SALL1_21062744_ChIP-ChIP_HESCs_Human2.16454008
39FLI1_27457419_Chip-Seq_LIVER_Mouse2.08684923
40FOXP3_21729870_ChIP-Seq_TREG_Human2.08395483
41E2F4_17652178_ChIP-ChIP_JURKAT_Human2.05739679
42P300_19829295_ChIP-Seq_ESCs_Human2.05670447
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04477611
44CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04296922
45ELK1_19687146_ChIP-ChIP_HELA_Human1.98131440
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.96123532
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92005856
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89284444
49* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.88001802
50* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81639941
51TTF2_22483619_ChIP-Seq_HELA_Human1.77622624
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75667079
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.72198978
54ER_23166858_ChIP-Seq_MCF-7_Human1.72035384
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69129420
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67206694
57* GABP_19822575_ChIP-Seq_HepG2_Human1.66770452
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.60735030
59* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.60187764
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59839528
61SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.58148687
62EZH2_22144423_ChIP-Seq_EOC_Human1.57817354
63XRN2_22483619_ChIP-Seq_HELA_Human1.55565675
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54463181
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52195505
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49839730
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48298825
68IRF1_19129219_ChIP-ChIP_H3396_Human1.48258505
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45939685
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44987955
71DCP1A_22483619_ChIP-Seq_HELA_Human1.43663901
72CBP_20019798_ChIP-Seq_JUKART_Human1.43661049
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43661049
74AR_21909140_ChIP-Seq_LNCAP_Human1.42678279
75SMAD4_21799915_ChIP-Seq_A2780_Human1.42415801
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42014459
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.41778313
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41627728
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39552095
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39149596
81* TP53_22573176_ChIP-Seq_HFKS_Human1.38781409
82BCAT_22108803_ChIP-Seq_LS180_Human1.37939998
83STAT3_23295773_ChIP-Seq_U87_Human1.36529230
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35907892
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32629431
86AR_25329375_ChIP-Seq_VCAP_Human1.32034166
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29915982
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29861156
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29318638
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29318638
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.28691051
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28673902
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.27816347
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26970325
95* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26258410
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26053001
97GATA1_26923725_Chip-Seq_HPCs_Mouse1.25872637
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.24229711
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24119281
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23569140
101SOX2_19829295_ChIP-Seq_ESCs_Human1.23417406
102NANOG_19829295_ChIP-Seq_ESCs_Human1.23417406
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23236235
104TCF4_23295773_ChIP-Seq_U87_Human1.22842449
105TCF4_22108803_ChIP-Seq_LS180_Human1.21997174
106* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21738763
107RNF2_27304074_Chip-Seq_NSC_Mouse1.18348781
108THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18348627
109YY1_22570637_ChIP-Seq_MALME-3M_Human1.18175926
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17367374
111CBX2_27304074_Chip-Seq_ESCs_Mouse1.16473861
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15890118
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15498731
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15046204
115BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14328947
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.13957504
117KAP1_22055183_ChIP-Seq_ESCs_Mouse1.13229214
118SOX2_22085726_ChIP-Seq_NPCs_Mouse1.11864119
119NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10947216
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10880422
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10627663
122* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10510602
123NOTCH1_21737748_ChIP-Seq_TLL_Human1.09894987
124ELK1_22589737_ChIP-Seq_MCF10A_Human1.08095519
125CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07937578
126CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07691122
127POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07668842
128CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07024548
129AR_21572438_ChIP-Seq_LNCaP_Human1.07019195
130KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05451504
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05105442
132FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03888667
133RUNX2_22187159_ChIP-Seq_PCA_Human1.03339702
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03269105
135RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03037933
136ERG_20517297_ChIP-Seq_VCAP_Human1.02773738
137NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02294447
138P53_22387025_ChIP-Seq_ESCs_Mouse1.01257067
139GATA1_22025678_ChIP-Seq_K562_Human1.01088317
140* CRX_20693478_ChIP-Seq_RETINA_Mouse0.99698679
141* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99498095
142MYC_18940864_ChIP-ChIP_HL60_Human0.99419009
143AR_20517297_ChIP-Seq_VCAP_Human0.98751769
144PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97094143
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96967984
146E2F1_18555785_Chip-Seq_ESCs_Mouse0.96184689
147STAT3_18555785_Chip-Seq_ESCs_Mouse0.93413053
148E2F1_17053090_ChIP-ChIP_MCF-7_Human0.92781248
149LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92513739
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90294986
151EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90162496
152* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.89852354
153GATA3_21867929_ChIP-Seq_CD8_Mouse0.88861475
154STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85844645
155TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85503647
156SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84528874
157NANOG_20526341_ChIP-Seq_ESCs_Human0.83890833
158ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83725496
159CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83454642
160* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82485380
161HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81757343
162SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81110155
163ELF1_20517297_ChIP-Seq_JURKAT_Human0.80363012
164MYCN_18555785_ChIP-Seq_MESCs_Mouse0.79180234
165RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77537443
166SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77061679
167P300_27268052_Chip-Seq_Bcells_Human0.74396730
168FOXA1_25329375_ChIP-Seq_VCAP_Human0.74337618
169FOXA1_27270436_Chip-Seq_PROSTATE_Human0.74337618
170* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.74239943
171RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.69469955
172EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.69039157
173CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.68821668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.76249136
2MP0001986_abnormal_taste_sensitivity4.24261738
3MP0003136_yellow_coat_color4.20005028
4MP0005646_abnormal_pituitary_gland3.15725588
5MP0005075_abnormal_melanosome_morpholog2.97997673
6MP0006292_abnormal_olfactory_placode2.84040384
7MP0000569_abnormal_digit_pigmentation2.81625753
8MP0003186_abnormal_redox_activity2.69450644
9MP0002638_abnormal_pupillary_reflex2.57206921
10MP0002132_abnormal_respiratory_system2.46277856
11MP0004133_heterotaxia2.40250521
12MP0008004_abnormal_stomach_pH2.39489465
13MP0001529_abnormal_vocalization2.30731692
14MP0003693_abnormal_embryo_hatching2.22563587
15MP0001968_abnormal_touch/_nociception2.13635033
16MP0005623_abnormal_meninges_morphology2.06880290
17MP0009046_muscle_twitch2.05582625
18MP0008877_abnormal_DNA_methylation2.04805542
19MP0003880_abnormal_central_pattern2.03682812
20MP0005084_abnormal_gallbladder_morpholo1.98250653
21MP0002736_abnormal_nociception_after1.97980278
22MP0000372_irregular_coat_pigmentation1.91450322
23MP0000049_abnormal_middle_ear1.89476860
24MP0004381_abnormal_hair_follicle1.85694139
25MP0002160_abnormal_reproductive_system1.77001414
26MP0005645_abnormal_hypothalamus_physiol1.71277106
27MP0003724_increased_susceptibility_to1.71075568
28MP0002938_white_spotting1.70880868
29MP0008789_abnormal_olfactory_epithelium1.69267338
30MP0003646_muscle_fatigue1.68482929
31MP0008932_abnormal_embryonic_tissue1.68249203
32MP0009379_abnormal_foot_pigmentation1.64951853
33MP0004957_abnormal_blastocyst_morpholog1.62635970
34MP0001764_abnormal_homeostasis1.62064614
35MP0002272_abnormal_nervous_system1.59416595
36MP0006276_abnormal_autonomic_nervous1.57071734
37MP0003195_calcinosis1.56033002
38MP0009745_abnormal_behavioral_response1.55573960
39MP0001485_abnormal_pinna_reflex1.48198923
40MP0003718_maternal_effect1.47699702
41MP0001270_distended_abdomen1.46250687
42MP0001486_abnormal_startle_reflex1.45810814
43MP0003890_abnormal_embryonic-extraembry1.43786567
44MP0002735_abnormal_chemical_nociception1.43510959
45MP0002282_abnormal_trachea_morphology1.43132555
46MP0002249_abnormal_larynx_morphology1.43080745
47MP0006036_abnormal_mitochondrial_physio1.42955007
48MP0004782_abnormal_surfactant_physiolog1.42014273
49MP0008058_abnormal_DNA_repair1.36851716
50MP0006072_abnormal_retinal_apoptosis1.36129744
51MP0008872_abnormal_physiological_respon1.35684481
52MP0002234_abnormal_pharynx_morphology1.35325891
53MP0002095_abnormal_skin_pigmentation1.34359345
54MP0004147_increased_porphyrin_level1.33864599
55MP0000749_muscle_degeneration1.32445158
56MP0008875_abnormal_xenobiotic_pharmacok1.31998241
57MP0001929_abnormal_gametogenesis1.31121673
58MP0001188_hyperpigmentation1.31018019
59MP0009697_abnormal_copulation1.29771033
60MP0003315_abnormal_perineum_morphology1.28225073
61MP0005636_abnormal_mineral_homeostasis1.27922692
62MP0002396_abnormal_hematopoietic_system1.25012195
63MP0010094_abnormal_chromosome_stability1.24941213
64MP0006054_spinal_hemorrhage1.23779000
65MP0005410_abnormal_fertilization1.23430246
66MP0005389_reproductive_system_phenotype1.22322728
67MP0003786_premature_aging1.21424957
68MP0006035_abnormal_mitochondrial_morpho1.20238039
69MP0000490_abnormal_crypts_of1.19818401
70MP0010386_abnormal_urinary_bladder1.19793882
71MP0002928_abnormal_bile_duct1.19643142
72MP0000427_abnormal_hair_cycle1.19602362
73MP0005423_abnormal_somatic_nervous1.19526481
74MP0003787_abnormal_imprinting1.17130195
75MP0005174_abnormal_tail_pigmentation1.16972623
76MP0003698_abnormal_male_reproductive1.16321908
77MP0003763_abnormal_thymus_physiology1.15705637
78MP0002822_catalepsy1.14998826
79MP0001293_anophthalmia1.14944640
80MP0000428_abnormal_craniofacial_morphol1.13832923
81MP0002405_respiratory_system_inflammati1.13393730
82MP0009643_abnormal_urine_homeostasis1.11560589
83MP0002067_abnormal_sensory_capabilities1.11011142
84MP0005253_abnormal_eye_physiology1.09668043
85MP0002557_abnormal_social/conspecific_i1.09609561
86MP0004145_abnormal_muscle_electrophysio1.09538233
87MP0003938_abnormal_ear_development1.09209256
88MP0004885_abnormal_endolymph1.08132901
89MP0005499_abnormal_olfactory_system1.06686579
90MP0005394_taste/olfaction_phenotype1.06686579
91MP0000778_abnormal_nervous_system1.06544176
92MP0002064_seizures1.06505482
93MP0005551_abnormal_eye_electrophysiolog1.06157126
94MP0004924_abnormal_behavior1.05984764
95MP0005386_behavior/neurological_phenoty1.05984764
96MP0004742_abnormal_vestibular_system1.05907264
97MP0003077_abnormal_cell_cycle1.03912775
98MP0003123_paternal_imprinting1.03881742
99MP0002210_abnormal_sex_determination1.02947786
100MP0000647_abnormal_sebaceous_gland1.01955934
101MP0000383_abnormal_hair_follicle1.01425269
102MP0002572_abnormal_emotion/affect_behav1.01409507
103MP0001765_abnormal_ion_homeostasis1.01183449
104MP0000470_abnormal_stomach_morphology1.00821571
105MP0004043_abnormal_pH_regulation0.98886150
106MP0003121_genomic_imprinting0.98830810
107MP0002837_dystrophic_cardiac_calcinosis0.98697803
108MP0008057_abnormal_DNA_replication0.97971945
109MP0001501_abnormal_sleep_pattern0.97715016
110MP0002163_abnormal_gland_morphology0.97346452
111MP0003942_abnormal_urinary_system0.95732705
112MP0000631_abnormal_neuroendocrine_gland0.95018827
113MP0003011_delayed_dark_adaptation0.94794109
114MP0005195_abnormal_posterior_eye0.94485388
115MP0003937_abnormal_limbs/digits/tail_de0.94331404
116MP0002751_abnormal_autonomic_nervous0.93485027
117MP0004215_abnormal_myocardial_fiber0.92928817
118MP0005391_vision/eye_phenotype0.92843272
119MP0001324_abnormal_eye_pigmentation0.91289195
120MP0002734_abnormal_mechanical_nocicepti0.90393158
121MP0005332_abnormal_amino_acid0.90336485
122MP0004019_abnormal_vitamin_homeostasis0.89526679
123MP0001970_abnormal_pain_threshold0.88864137
124MP0003567_abnormal_fetal_cardiomyocyte0.88067794
125MP0002277_abnormal_respiratory_mucosa0.87483778
126MP0001286_abnormal_eye_development0.87468645
127MP0002184_abnormal_innervation0.87071985
128MP0002752_abnormal_somatic_nervous0.84882078
129MP0003656_abnormal_erythrocyte_physiolo0.84085235
130MP0004142_abnormal_muscle_tone0.83338436
131MP0002102_abnormal_ear_morphology0.82654961
132MP0003635_abnormal_synaptic_transmissio0.81668251
133MP0008995_early_reproductive_senescence0.80800995
134MP0001849_ear_inflammation0.78684184
135MP0009250_abnormal_appendicular_skeleto0.78440765
136MP0005395_other_phenotype0.78394375
137MP0002177_abnormal_outer_ear0.78108767
138MP0001663_abnormal_digestive_system0.77837988
139MP0001145_abnormal_male_reproductive0.77386350
140MP0001756_abnormal_urination0.77304905
141MP0001853_heart_inflammation0.76404811
142MP0002233_abnormal_nose_morphology0.76389699
143MP0001727_abnormal_embryo_implantation0.74980139
144MP0000653_abnormal_sex_gland0.73291727
145MP0002876_abnormal_thyroid_physiology0.73038476
146MP0008007_abnormal_cellular_replicative0.72789479
147MP0001984_abnormal_olfaction0.70976145
148MP0001944_abnormal_pancreas_morphology0.70820621
149MP0005266_abnormal_metabolism0.68567483
150MP0010030_abnormal_orbit_morphology0.67684313
151MP0000358_abnormal_cell_content/0.67398226
152MP0003866_abnormal_defecation0.66978476
153MP0005319_abnormal_enzyme/_coenzyme0.66978083
154MP0001905_abnormal_dopamine_level0.65619959

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.76945594
2Rhinitis (HP:0012384)9.44991383
3Abnormal respiratory motile cilium morphology (HP:0005938)9.01101860
4Abnormal respiratory epithelium morphology (HP:0012253)9.01101860
5Absent/shortened dynein arms (HP:0200106)5.84742664
6Dynein arm defect of respiratory motile cilia (HP:0012255)5.84742664
7Chronic bronchitis (HP:0004469)5.42022365
8Bronchiectasis (HP:0002110)5.30762011
9Pancreatic fibrosis (HP:0100732)4.99027856
10Chronic sinusitis (HP:0011109)4.59049202
11True hermaphroditism (HP:0010459)4.43380631
12Recurrent sinusitis (HP:0011108)3.97978122
13Nasal polyposis (HP:0100582)3.60136848
14Bronchitis (HP:0012387)3.38306882
15Pancreatic cysts (HP:0001737)3.10652391
16Median cleft lip (HP:0000161)3.08414333
17Abnormality of the nasal mucosa (HP:0000433)2.97913790
18Nephronophthisis (HP:0000090)2.94789031
19Abnormality of midbrain morphology (HP:0002418)2.91706227
20Molar tooth sign on MRI (HP:0002419)2.91706227
21Medial flaring of the eyebrow (HP:0010747)2.85217324
22Lipid accumulation in hepatocytes (HP:0006561)2.82661752
23Increased hepatocellular lipid droplets (HP:0006565)2.82539447
24Congenital primary aphakia (HP:0007707)2.80854756
25Gait imbalance (HP:0002141)2.73665421
26Abnormality of the renal cortex (HP:0011035)2.67293108
27Facial cleft (HP:0002006)2.67189694
28Supernumerary spleens (HP:0009799)2.63669618
29Nephrogenic diabetes insipidus (HP:0009806)2.63383496
30Congenital hepatic fibrosis (HP:0002612)2.59215281
31Occipital encephalocele (HP:0002085)2.51808103
32Type II lissencephaly (HP:0007260)2.51689936
33Postaxial foot polydactyly (HP:0001830)2.49938809
343-Methylglutaconic aciduria (HP:0003535)2.49708372
35Cystic liver disease (HP:0006706)2.46357726
36Congenital, generalized hypertrichosis (HP:0004540)2.45866362
37Abnormality of dentin (HP:0010299)2.42581304
38Abnormality of cells of the erythroid lineage (HP:0012130)2.42129049
39Abnormality of the labia minora (HP:0012880)2.39298310
40Genital tract atresia (HP:0001827)2.37082929
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34661549
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34661549
43Attenuation of retinal blood vessels (HP:0007843)2.33843009
44Abnormality of the renal medulla (HP:0100957)2.33239476
45Tubulointerstitial nephritis (HP:0001970)2.29466050
46Aplasia/Hypoplasia of the tongue (HP:0010295)2.29138545
47Pendular nystagmus (HP:0012043)2.28952830
48Intestinal atresia (HP:0011100)2.28699549
49Colon cancer (HP:0003003)2.27994116
50Concave nail (HP:0001598)2.27651004
5111 pairs of ribs (HP:0000878)2.26972016
52Acute necrotizing encephalopathy (HP:0006965)2.26717566
53Hypothermia (HP:0002045)2.26532905
54Congenital stationary night blindness (HP:0007642)2.25591132
55Preaxial hand polydactyly (HP:0001177)2.22808758
56Hyperventilation (HP:0002883)2.20713700
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.18243967
58Abolished electroretinogram (ERG) (HP:0000550)2.17860584
59Abnormal number of erythroid precursors (HP:0012131)2.16901972
60Abnormal mitochondria in muscle tissue (HP:0008316)2.16036425
61Renal cortical cysts (HP:0000803)2.15665591
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.13695867
63Hypoplasia of the pons (HP:0012110)2.13218020
64Abnormality of the pons (HP:0007361)2.12887373
65Exercise intolerance (HP:0003546)2.12692618
66Cerebral edema (HP:0002181)2.11805245
67Gaze-evoked nystagmus (HP:0000640)2.11562855
68Focal motor seizures (HP:0011153)2.11213459
69Renal Fanconi syndrome (HP:0001994)2.10267711
70Mitochondrial inheritance (HP:0001427)2.09704446
71Increased serum lactate (HP:0002151)2.09498621
72Chromsome breakage (HP:0040012)2.08399125
73Vaginal atresia (HP:0000148)2.07726136
74Abnormal biliary tract physiology (HP:0012439)2.07169617
75Bile duct proliferation (HP:0001408)2.07169617
76Abnormality of macular pigmentation (HP:0008002)2.06880840
77Methylmalonic acidemia (HP:0002912)2.05928739
78Abnormal sex determination (HP:0012244)2.05773923
79Sex reversal (HP:0012245)2.05773923
80Abnormality of the ileum (HP:0001549)2.05559831
81Meckel diverticulum (HP:0002245)2.04846614
82Metaphyseal dysplasia (HP:0100255)2.04808048
83Asplenia (HP:0001746)2.04105311
84Lissencephaly (HP:0001339)2.02908009
85Tubular atrophy (HP:0000092)2.02818517
86Recurrent bronchitis (HP:0002837)2.02496559
87Poor coordination (HP:0002370)2.02072876
88Bony spicule pigmentary retinopathy (HP:0007737)2.00860851
89Type I transferrin isoform profile (HP:0003642)2.00283142
90Abnormal ciliary motility (HP:0012262)11.0624370
91Abnormal respiratory motile cilium physiology (HP:0012261)10.7499646
92Acute encephalopathy (HP:0006846)1.97720508
93Cerebellar dysplasia (HP:0007033)1.97293243
94Chronic hepatic failure (HP:0100626)1.97245097
95Volvulus (HP:0002580)1.97200319
96Large for gestational age (HP:0001520)1.95847600
97Abnormal drinking behavior (HP:0030082)1.92345914
98Polydipsia (HP:0001959)1.92345914
99Optic nerve hypoplasia (HP:0000609)1.92083165
100Lactic acidosis (HP:0003128)1.90418222
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89563152
102Abnormality of alanine metabolism (HP:0010916)1.89563152
103Hyperalaninemia (HP:0003348)1.89563152
104Recurrent otitis media (HP:0000403)1.89218439
105Hepatic necrosis (HP:0002605)1.89152994
106Sclerocornea (HP:0000647)1.88913279
107Hepatocellular necrosis (HP:0001404)1.88650240
108Male pseudohermaphroditism (HP:0000037)1.87893187
109Increased CSF lactate (HP:0002490)1.87447689
110Methylmalonic aciduria (HP:0012120)1.87319582
111Anencephaly (HP:0002323)1.87290960
112Abnormality of the dental root (HP:0006486)1.85387125
113Taurodontia (HP:0000679)1.85387125
114Abnormality of permanent molar morphology (HP:0011071)1.85387125
115Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83201230
116Infertility (HP:0000789)1.83080840
117Abnormal rod and cone electroretinograms (HP:0008323)1.82990000
118Postaxial hand polydactyly (HP:0001162)1.82958556
119Aplasia/Hypoplasia of the spleen (HP:0010451)1.82630295
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82055030
121Abnormal protein N-linked glycosylation (HP:0012347)1.82055030
122Abnormal protein glycosylation (HP:0012346)1.82055030
123Abnormal glycosylation (HP:0012345)1.82055030
124Duplicated collecting system (HP:0000081)1.81291086
125Abnormality of chromosome stability (HP:0003220)1.80920339
126Abnormality of the renal collecting system (HP:0004742)1.80159188
127Keratoconus (HP:0000563)1.79930254
128Increased corneal curvature (HP:0100692)1.79930254
129Septo-optic dysplasia (HP:0100842)1.75685204
130Optic nerve coloboma (HP:0000588)1.75515916
131Dandy-Walker malformation (HP:0001305)1.75366398
132Sloping forehead (HP:0000340)1.73628459
133Progressive macrocephaly (HP:0004481)1.73468844
134Stage 5 chronic kidney disease (HP:0003774)1.72610454
135Broad-based gait (HP:0002136)1.71248795
136Polyuria (HP:0000103)1.69778067
137Severe visual impairment (HP:0001141)1.66476930
138Abnormality of the dental pulp (HP:0006479)1.64750632
139Optic disc pallor (HP:0000543)1.63149161
140Abnormality of molar morphology (HP:0011070)1.60905435
141Abnormality of molar (HP:0011077)1.60905435
142Generalized aminoaciduria (HP:0002909)1.60207516
143Aplasia/Hypoplasia of the tibia (HP:0005772)1.59974498
144Abnormality of abdominal situs (HP:0011620)1.59033406
145Abdominal situs inversus (HP:0003363)1.59033406
146Furrowed tongue (HP:0000221)1.58812731
147Aplasia/Hypoplasia of the lens (HP:0008063)1.58238272
148Increased intramyocellular lipid droplets (HP:0012240)1.57934567
149Tubulointerstitial abnormality (HP:0001969)1.56854017
150Bifid tongue (HP:0010297)1.56651887
151Reticulocytopenia (HP:0001896)1.56318684
152Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.55815347
153Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.55793221
154Aplastic anemia (HP:0001915)1.55232317
155Aplasia/Hypoplasia of the sacrum (HP:0008517)1.54648782
156Oculomotor apraxia (HP:0000657)1.53050232
157Abnormal urine output (HP:0012590)1.51418460

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK157.06033619
2FRK4.56147096
3WEE13.87043762
4VRK13.41801134
5NUAK12.78831703
6BMPR1B2.71483005
7ZAK2.65423891
8MST42.62404248
9PNCK2.55328855
10VRK22.51979208
11STK162.49974240
12BRSK22.47884959
13BUB12.13538288
14PASK2.08353235
15MAP4K22.08298859
16MAP3K41.95189141
17PIM21.94181017
18CASK1.92965246
19TNIK1.88228072
20ARAF1.75305267
21INSRR1.67197214
22MKNK11.67106137
23TRIM281.65067463
24TSSK61.64628846
25DYRK31.56323077
26BLK1.54627128
27MAPK131.48237331
28PBK1.44820619
29NME21.44811658
30GRK11.44638002
31AURKA1.42542718
32TLK11.38714234
33BCKDK1.37732627
34TEC1.35800107
35TAOK31.34548025
36RPS6KB21.29623392
37MAPKAPK31.29205607
38MKNK21.29144914
39FLT31.26269991
40ACVR1B1.25270541
41MYLK1.24146532
42MARK11.21571369
43RPS6KA41.19918820
44CDK81.17866455
45STK38L1.14083355
46PDK31.13978956
47PDK41.13978956
48BRSK11.13612867
49MAP3K121.09153599
50PAK31.08131832
51OXSR11.06044024
52BTK1.01933817
53TAF11.01818265
54DYRK21.01403538
55BCR0.99866043
56CCNB10.99599257
57MAP2K20.98344400
58LRRK20.97741115
59PLK20.97702893
60PLK30.95963074
61STK100.92841739
62NTRK30.89861479
63PRKCG0.89646274
64PLK10.88142939
65MAP4K10.86816044
66ITK0.85302530
67PLK40.85032569
68TESK10.84160131
69TRPM70.84137362
70PRKCE0.83502108
71MAP2K70.83370489
72MAPKAPK50.83249128
73STK240.83219397
74WNK40.82124235
75RPS6KC10.82040970
76RPS6KL10.82040970
77NME10.82015030
78TGFBR10.81163633
79TESK20.80445521
80RPS6KA20.78465031
81STK390.77884229
82PRKCI0.77661376
83GRK70.77395056
84RPS6KA60.75966611
85CAMKK20.74871350
86TTK0.74286467
87BRAF0.70998881
88KIT0.70900047
89CDC70.68080625
90ADRBK20.67643117
91EPHA40.67400972
92CSNK2A10.67074285
93LMTK20.66667913
94PAK20.65221947
95AURKB0.64698665
96MAPKAPK20.64668795
97NLK0.64191078
98STK30.63837688
99PHKG20.63610904
100PHKG10.63610904
101EIF2AK10.63446196
102CDK30.63107336
103CSNK1G10.61793616
104RPS6KA50.61140187
105CSNK1G20.60291049
106HIPK20.58639025
107KDR0.57915705
108CDK190.57263198
109MATK0.56799289
110FGFR20.55674201
111PDK20.53190686
112CSNK2A20.52451703
113CDK70.52231292
114ZAP700.51417886
115CAMK10.50460027
116YES10.50090815
117GRK60.50035489
118TIE10.49533519
119ATR0.49279557
120CSNK1G30.48800016
121CAMK2A0.46067764
122WNK30.45515229
123ERBB30.45042317
124ADRBK10.44790603
125MUSK0.43095687
126EEF2K0.41526835
127ATM0.41282282
128EIF2AK30.40762682
129PIK3CA0.39672974
130MINK10.39584048
131SRPK10.39306976
132CSNK1A1L0.38048828
133PRKCQ0.37656150
134PKN10.37284646
135EIF2AK20.36838214
136PRKG10.36811783
137CHEK20.36763098
138PRKACB0.35931932
139ROCK20.35493130
140PINK10.35420140
141SIK30.35314329
142PRKACA0.35149215
143OBSCN0.35078135
144TXK0.34803226
145PIK3CG0.33923233
146TNK20.33756838
147NEK90.33491338
148MAPK30.31215759
149AKT20.31189623
150IRAK30.30842156
151NEK10.29928214

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.38794492
2Huntingtons disease_Homo sapiens_hsa050163.45414986
3Oxidative phosphorylation_Homo sapiens_hsa001903.45047775
4Parkinsons disease_Homo sapiens_hsa050123.11174878
5Proteasome_Homo sapiens_hsa030503.10637136
6Protein export_Homo sapiens_hsa030603.06129880
7DNA replication_Homo sapiens_hsa030302.99635954
8Mismatch repair_Homo sapiens_hsa034302.74535693
9Pyrimidine metabolism_Homo sapiens_hsa002402.71769274
10Homologous recombination_Homo sapiens_hsa034402.45719212
11RNA polymerase_Homo sapiens_hsa030202.36475884
12Nucleotide excision repair_Homo sapiens_hsa034202.33989756
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30357965
14Alzheimers disease_Homo sapiens_hsa050102.13647584
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.02922377
16Base excision repair_Homo sapiens_hsa034102.02574202
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.92646131
18Purine metabolism_Homo sapiens_hsa002301.88323562
19Spliceosome_Homo sapiens_hsa030401.76071010
20Nicotine addiction_Homo sapiens_hsa050331.75691813
21Phototransduction_Homo sapiens_hsa047441.67542899
22Glutathione metabolism_Homo sapiens_hsa004801.59739743
23Selenocompound metabolism_Homo sapiens_hsa004501.58886449
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51626152
25Pyruvate metabolism_Homo sapiens_hsa006201.50556891
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50308717
27Nitrogen metabolism_Homo sapiens_hsa009101.48079033
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.41808555
29Non-homologous end-joining_Homo sapiens_hsa034501.37495787
30Basal transcription factors_Homo sapiens_hsa030221.35750698
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31481268
32Propanoate metabolism_Homo sapiens_hsa006401.28526610
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.25244391
34Galactose metabolism_Homo sapiens_hsa000521.22003411
35Vitamin B6 metabolism_Homo sapiens_hsa007501.14450094
36Butanoate metabolism_Homo sapiens_hsa006501.13660182
37RNA degradation_Homo sapiens_hsa030181.13394084
38Cardiac muscle contraction_Homo sapiens_hsa042601.13097354
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12756950
40Arachidonic acid metabolism_Homo sapiens_hsa005901.12631329
41RNA transport_Homo sapiens_hsa030131.08795661
42Peroxisome_Homo sapiens_hsa041461.08699139
43Caffeine metabolism_Homo sapiens_hsa002321.05254940
44Fanconi anemia pathway_Homo sapiens_hsa034601.02816003
45Fatty acid elongation_Homo sapiens_hsa000621.02004792
46Cell cycle_Homo sapiens_hsa041100.98669246
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98464942
48Metabolic pathways_Homo sapiens_hsa011000.96645200
49Fructose and mannose metabolism_Homo sapiens_hsa000510.95111484
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95090884
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94051445
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93867068
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92366028
54Folate biosynthesis_Homo sapiens_hsa007900.90738969
55Regulation of autophagy_Homo sapiens_hsa041400.90230485
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90200085
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90185119
58One carbon pool by folate_Homo sapiens_hsa006700.89217654
59Carbon metabolism_Homo sapiens_hsa012000.89094345
60Sulfur metabolism_Homo sapiens_hsa009200.88675000
61Olfactory transduction_Homo sapiens_hsa047400.87763360
62Steroid biosynthesis_Homo sapiens_hsa001000.86085243
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86029370
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85587685
65Histidine metabolism_Homo sapiens_hsa003400.84879513
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83954514
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83763984
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.83410096
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81568855
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.81298736
71Linoleic acid metabolism_Homo sapiens_hsa005910.80296006
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76004772
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75091702
74Morphine addiction_Homo sapiens_hsa050320.74690033
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.74261184
76GABAergic synapse_Homo sapiens_hsa047270.72869590
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71215007
78Other glycan degradation_Homo sapiens_hsa005110.70321439
79Antigen processing and presentation_Homo sapiens_hsa046120.69622664
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68674774
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68514103
82Serotonergic synapse_Homo sapiens_hsa047260.62870041
83Glutamatergic synapse_Homo sapiens_hsa047240.60996104
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60085604
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.59661803
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59183314
87Arginine and proline metabolism_Homo sapiens_hsa003300.59042101
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56296806
89Biosynthesis of amino acids_Homo sapiens_hsa012300.55925723
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55429153
91Chemical carcinogenesis_Homo sapiens_hsa052040.55286863
92Pentose phosphate pathway_Homo sapiens_hsa000300.55248926
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55242577
94ABC transporters_Homo sapiens_hsa020100.54175077
95Phenylalanine metabolism_Homo sapiens_hsa003600.53446915
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52787619
97Circadian entrainment_Homo sapiens_hsa047130.52123320
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51923256
99Fatty acid degradation_Homo sapiens_hsa000710.51153562
100N-Glycan biosynthesis_Homo sapiens_hsa005100.49478325
101Oocyte meiosis_Homo sapiens_hsa041140.49332216
102Tryptophan metabolism_Homo sapiens_hsa003800.48406154
103Fatty acid metabolism_Homo sapiens_hsa012120.48076553
104Glycerolipid metabolism_Homo sapiens_hsa005610.43526359
105beta-Alanine metabolism_Homo sapiens_hsa004100.43051543
106Tyrosine metabolism_Homo sapiens_hsa003500.41681132
107Insulin secretion_Homo sapiens_hsa049110.40050596
108Collecting duct acid secretion_Homo sapiens_hsa049660.39779175
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39558418
110Ether lipid metabolism_Homo sapiens_hsa005650.36095035
111Sphingolipid metabolism_Homo sapiens_hsa006000.35192044
112Hedgehog signaling pathway_Homo sapiens_hsa043400.32814539
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32739502
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.32293859
115Basal cell carcinoma_Homo sapiens_hsa052170.31069892
116Sulfur relay system_Homo sapiens_hsa041220.30799986
117p53 signaling pathway_Homo sapiens_hsa041150.30515591
118Circadian rhythm_Homo sapiens_hsa047100.30328225
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29976038
120Starch and sucrose metabolism_Homo sapiens_hsa005000.28934843
121Taste transduction_Homo sapiens_hsa047420.28570109
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28284094
123Dopaminergic synapse_Homo sapiens_hsa047280.27984267
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26874479
125Alcoholism_Homo sapiens_hsa050340.25983039
126Ovarian steroidogenesis_Homo sapiens_hsa049130.24875491
127Epstein-Barr virus infection_Homo sapiens_hsa051690.23590078
128Retinol metabolism_Homo sapiens_hsa008300.17818858
129PPAR signaling pathway_Homo sapiens_hsa033200.17479736
130Vibrio cholerae infection_Homo sapiens_hsa051100.16858524
131Primary immunodeficiency_Homo sapiens_hsa053400.13940765

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