ASCC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.15649469
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.15649469
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.64857595
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.63469845
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.63469845
6modulation by symbiont of host immune response (GO:0052553)4.63469845
7positive regulation by symbiont of host defense response (GO:0052509)4.63469845
8modulation by symbiont of host defense response (GO:0052031)4.63469845
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.63469845
10neutrophil activation involved in immune response (GO:0002283)4.22570301
11regulation of B cell receptor signaling pathway (GO:0050855)4.04953326
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.02732577
13detection of other organism (GO:0098543)3.91240353
14detection of bacterium (GO:0016045)3.89765669
15positive thymic T cell selection (GO:0045059)3.78949137
16macrophage activation involved in immune response (GO:0002281)3.72624578
17immunoglobulin mediated immune response (GO:0016064)3.67312973
18response to peptidoglycan (GO:0032494)3.66359848
19regulation of interferon-beta biosynthetic process (GO:0045357)3.63824631
20folic acid-containing compound biosynthetic process (GO:0009396)3.60663235
21nuclear pore complex assembly (GO:0051292)3.56491796
22negative thymic T cell selection (GO:0045060)3.53619273
23negative regulation of erythrocyte differentiation (GO:0045647)3.52416355
24leukocyte aggregation (GO:0070486)3.50115065
25protein localization to kinetochore (GO:0034501)3.48507260
26negative T cell selection (GO:0043383)3.45226684
27nuclear pore organization (GO:0006999)3.40733602
28negative regulation of interleukin-12 production (GO:0032695)3.38220756
29positive regulation of granulocyte differentiation (GO:0030854)3.37787172
30negative regulation of lymphocyte mediated immunity (GO:0002707)3.36865500
31detection of external biotic stimulus (GO:0098581)3.34433533
32DNA unwinding involved in DNA replication (GO:0006268)3.31060484
33mitotic nuclear envelope disassembly (GO:0007077)3.29004727
34dosage compensation (GO:0007549)3.28391095
35response to host immune response (GO:0052572)3.24039131
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.24039131
37regulation of necroptotic process (GO:0060544)3.21016506
38respiratory burst (GO:0045730)3.19439468
39hemoglobin metabolic process (GO:0020027)3.19373904
40thymic T cell selection (GO:0045061)3.17877202
41NIK/NF-kappaB signaling (GO:0038061)3.15568760
42B cell receptor signaling pathway (GO:0050853)3.15265821
43negative regulation of leukocyte mediated immunity (GO:0002704)3.15027748
44neutrophil activation (GO:0042119)3.14967451
45response to interleukin-15 (GO:0070672)3.12799040
46cellular extravasation (GO:0045123)3.12311979
47Arp2/3 complex-mediated actin nucleation (GO:0034314)3.11967636
48positive regulation of B cell differentiation (GO:0045579)3.10567883
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.09849419
50response to host (GO:0075136)3.09849419
51response to host defenses (GO:0052200)3.09849419
52IMP biosynthetic process (GO:0006188)3.09722212
53regulation of mast cell degranulation (GO:0043304)3.09183953
54protein localization to chromosome, centromeric region (GO:0071459)3.08041985
55positive T cell selection (GO:0043368)3.06206248
56oxygen transport (GO:0015671)3.04858479
57protoporphyrinogen IX metabolic process (GO:0046501)3.03976766
58modulation by virus of host process (GO:0019054)3.03796203
59regulation of B cell differentiation (GO:0045577)3.03318486
60membrane disassembly (GO:0030397)3.03190993
61nuclear envelope disassembly (GO:0051081)3.03190993
62T cell selection (GO:0045058)3.00346251
63myeloid cell activation involved in immune response (GO:0002275)2.97539367
64detection of molecule of bacterial origin (GO:0032490)2.97156595
65regulation of myeloid leukocyte mediated immunity (GO:0002886)2.94883809
66granulocyte activation (GO:0036230)2.94423735
67regulation of translational fidelity (GO:0006450)2.93655533
68response to muramyl dipeptide (GO:0032495)2.92711129
69negative regulation of phagocytosis (GO:0050765)2.92001004
70positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.91169740
71heterochromatin organization (GO:0070828)2.89938712
72cellular response to type I interferon (GO:0071357)2.88901253
73type I interferon signaling pathway (GO:0060337)2.88901253
74nucleobase biosynthetic process (GO:0046112)2.88822654
75negative regulation of innate immune response (GO:0045824)2.88796072
76microglial cell activation (GO:0001774)2.88298202
77cellular response to virus (GO:0098586)2.88196621
78response to type I interferon (GO:0034340)2.88172905
79regulation of leukocyte degranulation (GO:0043300)2.87683352
80regulation of platelet aggregation (GO:0090330)2.87288502
81mitotic sister chromatid cohesion (GO:0007064)2.84794142
82negative regulation of T cell mediated immunity (GO:0002710)2.82888266
83pore complex assembly (GO:0046931)2.81698515
84cellular response to interleukin-15 (GO:0071350)2.81534274
85detection of biotic stimulus (GO:0009595)2.81384067
86B cell mediated immunity (GO:0019724)2.80541438
87modulation by symbiont of host cellular process (GO:0044068)2.79415424
88T cell migration (GO:0072678)2.78818460
89positive regulation of Cdc42 GTPase activity (GO:0043089)2.75742170
90regulation of mast cell activation involved in immune response (GO:0033006)2.75696896
91negative regulation of necroptotic process (GO:0060546)2.75411462
92tolerance induction (GO:0002507)2.74915280
93DNA duplex unwinding (GO:0032508)2.74645102
94DNA geometric change (GO:0032392)2.74138635
95macrophage activation (GO:0042116)2.72349185
96regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.71247026
97regulation of granulocyte differentiation (GO:0030852)2.70716812
98negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.70418603
99regulation of translational termination (GO:0006449)2.69691986
100purine nucleobase biosynthetic process (GO:0009113)2.69638336
101neutrophil mediated immunity (GO:0002446)2.69162290
102mRNA stabilization (GO:0048255)2.67761284
103RNA stabilization (GO:0043489)2.67761284
104IMP metabolic process (GO:0046040)2.67526136
105positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.67140682
106antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.65339646
107antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.65339646
108leukocyte degranulation (GO:0043299)2.65045560
109tetrahydrofolate metabolic process (GO:0046653)2.62646019
110lipopolysaccharide-mediated signaling pathway (GO:0031663)2.60619217
111positive regulation of protein import into nucleus, translocation (GO:0033160)2.59263487
112regulation of necrotic cell death (GO:0010939)2.59038725
113positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.59025602
114negative regulation of interleukin-6 production (GO:0032715)2.58719373
115regulation of RNA export from nucleus (GO:0046831)2.57862846
1163-UTR-mediated mRNA stabilization (GO:0070935)2.57621482
117formation of translation preinitiation complex (GO:0001731)2.57620072
118regulation of spindle organization (GO:0090224)2.55947357
119germinal center formation (GO:0002467)2.55061623
120pinocytosis (GO:0006907)2.54309796
121chromosome condensation (GO:0030261)2.53478727
122regulation of dendritic cell antigen processing and presentation (GO:0002604)2.53413229
123mitotic chromosome condensation (GO:0007076)2.51898414
124defense response to protozoan (GO:0042832)2.51734556
125DNA strand elongation involved in DNA replication (GO:0006271)2.50452800
126nuclear envelope organization (GO:0006998)2.49709693
127folic acid metabolic process (GO:0046655)2.48924985
128regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.41751075
129mitotic sister chromatid segregation (GO:0000070)2.41521450
130DNA strand elongation (GO:0022616)2.40002338
131translesion synthesis (GO:0019985)2.39339053
132DNA conformation change (GO:0071103)2.38892251
133sister chromatid segregation (GO:0000819)2.38282091
134negative regulation of fatty acid transport (GO:2000192)2.38263462
135glycine metabolic process (GO:0006544)2.35626331
136maternal placenta development (GO:0001893)2.34327734
137regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.34293310
138regulation of mitotic spindle organization (GO:0060236)2.33977732
139gene silencing by RNA (GO:0031047)2.31332363
140response to UV-C (GO:0010225)2.31291737
141antigen processing and presentation of endogenous antigen (GO:0019883)2.30428394
142DNA packaging (GO:0006323)2.30120326
143DNA replication initiation (GO:0006270)2.29109159
144negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.28610991
145NLS-bearing protein import into nucleus (GO:0006607)2.27209992
146mitotic metaphase plate congression (GO:0007080)2.27163367
147mitotic G1 DNA damage checkpoint (GO:0031571)2.24812927
148positive regulation of histone deacetylation (GO:0031065)2.23650687
149COPI coating of Golgi vesicle (GO:0048205)2.22286701
150Golgi transport vesicle coating (GO:0048200)2.22286701
151regulation of gamma-delta T cell differentiation (GO:0045586)2.22173481
152T cell apoptotic process (GO:0070231)2.20545002
153regulation of histone H3-K9 methylation (GO:0051570)2.19817375
154negative regulation of histone methylation (GO:0031061)2.19657461
155monoubiquitinated protein deubiquitination (GO:0035520)2.19159989
156histone-serine phosphorylation (GO:0035404)2.17629840
157positive regulation of gamma-delta T cell activation (GO:0046645)2.17543519
158spliceosomal tri-snRNP complex assembly (GO:0000244)2.17127400
159gene silencing (GO:0016458)2.16997408
160epithelial cell differentiation involved in prostate gland development (GO:0060742)2.13925827
161endothelial tube morphogenesis (GO:0061154)2.13639391
162morphogenesis of an endothelium (GO:0003159)2.13639391
163DNA replication-dependent nucleosome organization (GO:0034723)2.13603099
164DNA replication-dependent nucleosome assembly (GO:0006335)2.13603099
165regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.13129308
166folic acid-containing compound metabolic process (GO:0006760)2.12803310
167telomere maintenance via semi-conservative replication (GO:0032201)2.12635360
168cellular hyperosmotic response (GO:0071474)2.10280991
169L-alpha-amino acid transmembrane transport (GO:1902475)2.10022128
170hippo signaling (GO:0035329)2.08109846
171antigen processing and presentation via MHC class Ib (GO:0002475)2.08012448
172regulation of cholesterol homeostasis (GO:2000188)2.07443619
173protein localization to chromosome (GO:0034502)2.06507012
174regulation of mRNA stability (GO:0043488)2.06400843
175positive regulation of nuclease activity (GO:0032075)2.06110952
176activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.05602348
177mitotic recombination (GO:0006312)2.05503542
178regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.05121612
179trophectodermal cell differentiation (GO:0001829)2.04258274
180regulation of hippo signaling (GO:0035330)2.03310228
181telomere maintenance via recombination (GO:0000722)2.02982846
182regulation of protein import into nucleus, translocation (GO:0033158)2.02889521
183positive regulation of SMAD protein import into nucleus (GO:0060391)2.02652866
184DNA replication checkpoint (GO:0000076)2.02418374
185positive regulation of chromosome segregation (GO:0051984)2.02091055
186apoptotic cell clearance (GO:0043277)2.01463863
187hepatocyte apoptotic process (GO:0097284)2.01183037
188chromatin assembly (GO:0031497)2.01182949
189regulation of gamma-delta T cell activation (GO:0046643)2.00563274
190regulation of RNA stability (GO:0043487)2.00510454
191nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)1.99973539

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.32894613
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.60751884
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.51921397
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.83845017
5MYC_22102868_ChIP-Seq_BL_Human2.60272584
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.57586766
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46675763
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22156322
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07174239
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.06344595
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98523702
12VDR_21846776_ChIP-Seq_THP-1_Human1.97789658
13TP63_17297297_ChIP-ChIP_HaCaT_Human1.96581890
14MYC_18555785_ChIP-Seq_MESCs_Mouse1.92915599
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.92562920
16KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89412610
17SPI1_23127762_ChIP-Seq_K562_Human1.87462790
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.82696686
19* AR_21909140_ChIP-Seq_LNCAP_Human1.82019980
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81911713
21STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79207562
22GATA1_19941827_ChIP-Seq_MEL_Mouse1.78030525
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77781844
24* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76452858
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64951336
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.64401761
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.63474580
28RUNX_20019798_ChIP-Seq_JUKART_Human1.62293277
29GATA1_19941826_ChIP-Seq_K562_Human1.60162527
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59728713
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57487735
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57354583
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55642175
34TCF7_22412390_ChIP-Seq_EML_Mouse1.55065253
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54967520
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51844365
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.51162655
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47687699
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47423190
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.46274779
41MAF_26560356_Chip-Seq_TH1_Human1.45857480
42GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45576564
43CLOCK_20551151_ChIP-Seq_293T_Human1.44604617
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.42588070
45BCL6_27268052_Chip-Seq_Bcells_Human1.39791256
46* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38514387
47RXR_22158963_ChIP-Seq_LIVER_Mouse1.38436174
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38353754
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38139529
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.37566100
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36233920
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35682883
53UTX_26944678_Chip-Seq_JUKART_Human1.35179504
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34647787
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33819845
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33709522
57BCOR_27268052_Chip-Seq_Bcells_Human1.32994356
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32252426
59CIITA_25753668_ChIP-Seq_RAJI_Human1.30914248
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30779397
61MYB_26560356_Chip-Seq_TH1_Human1.29942928
62GATA1_22025678_ChIP-Seq_K562_Human1.29635138
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29473270
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28160315
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26987159
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26978401
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24824227
68NCOR1_26117541_ChIP-Seq_K562_Human1.24241850
69TFEB_21752829_ChIP-Seq_HELA_Human1.23602007
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23598148
71GATA3_27048872_Chip-Seq_THYMUS_Human1.23394338
72P68_20966046_ChIP-Seq_HELA_Human1.23357216
73* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23096211
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21913556
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21630187
76KDM5A_27292631_Chip-Seq_BREAST_Human1.21515772
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19894697
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19668741
79* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19044446
80MYB_26560356_Chip-Seq_TH2_Human1.19008668
81MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18717087
82ATF3_27146783_Chip-Seq_COLON_Human1.18367560
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18291967
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18205517
85* XRN2_22483619_ChIP-Seq_HELA_Human1.17893236
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17037081
87KDM2B_26808549_Chip-Seq_DND41_Human1.15960472
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15870553
89STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15663587
90VDR_24763502_ChIP-Seq_THP-1_Human1.15469391
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.14369547
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14214998
93* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13259825
94RUNX1_22412390_ChIP-Seq_EML_Mouse1.12803651
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12190054
96NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10582194
97RACK7_27058665_Chip-Seq_MCF-7_Human1.09747771
98ZNF263_19887448_ChIP-Seq_K562_Human1.09672234
99* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09581860
100HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09186877
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08844039
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08821932
103MAF_26560356_Chip-Seq_TH2_Human1.08183698
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07781200
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07334704
106CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06587073
107* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06109496
108NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05454963
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05376592
110SMC4_20622854_ChIP-Seq_HELA_Human1.05309934
111* GATA2_19941826_ChIP-Seq_K562_Human1.05207461
112GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04927239
113SCL_19346495_ChIP-Seq_HPC-7_Human1.04592042
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04553806
115KDM2B_26808549_Chip-Seq_JURKAT_Human1.03057186
116LXR_22158963_ChIP-Seq_LIVER_Mouse1.02917835
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02436579
118* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99817630
119E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99263651
120GATA6_25053715_ChIP-Seq_YYC3_Human0.99189423
121* SPI1_23547873_ChIP-Seq_NB4_Human0.98839966
122* TET1_21451524_ChIP-Seq_MESCs_Mouse0.98031176
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97657052
124RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97316277
125ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97115898
126* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97045016
127TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96678030
128ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96469713
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95396081
130GABP_19822575_ChIP-Seq_HepG2_Human0.95075821
131RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95064469
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94447307
133CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94414409
134IRF8_21731497_ChIP-ChIP_J774_Mouse0.93800264
135STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93647789
136POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93326925
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92942002
138KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92547833
139CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91572001
140TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90916649
141P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90739538
142TP63_19390658_ChIP-ChIP_HaCaT_Human0.90003354
143LXR_22292898_ChIP-Seq_THP-1_Human0.89666975
144RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89069624
145CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89022680
146SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88594645

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.17596183
2MP0008260_abnormal_autophagy3.00581824
3MP0003724_increased_susceptibility_to2.89045470
4MP0005451_abnormal_body_composition2.56976654
5MP0010352_gastrointestinal_tract_polyps2.53399158
6MP0002419_abnormal_innate_immunity2.50568663
7MP0005025_abnormal_response_to2.49329730
8MP0005671_abnormal_response_to2.35908394
9MP0005000_abnormal_immune_tolerance2.33266489
10MP0003656_abnormal_erythrocyte_physiolo2.28977325
11MP0003111_abnormal_nucleus_morphology2.26619336
12MP0005387_immune_system_phenotype2.23677490
13MP0001790_abnormal_immune_system2.23677490
14MP0009785_altered_susceptibility_to2.21221591
15MP0002420_abnormal_adaptive_immunity2.20202412
16MP0003172_abnormal_lysosome_physiology2.18368567
17MP0001819_abnormal_immune_cell2.17703212
18MP0003693_abnormal_embryo_hatching2.16299463
19MP0002723_abnormal_immune_serum2.15894022
20MP0003566_abnormal_cell_adhesion1.98946405
21MP0010094_abnormal_chromosome_stability1.98171608
22MP0010307_abnormal_tumor_latency1.96634911
23MP0008057_abnormal_DNA_replication1.92458663
24MP0005076_abnormal_cell_differentiation1.86820589
25MP0002148_abnormal_hypersensitivity_rea1.86317466
26MP0003077_abnormal_cell_cycle1.84390053
27MP0002396_abnormal_hematopoietic_system1.77364296
28MP0006082_CNS_inflammation1.76173344
29MP0008007_abnormal_cellular_replicative1.69964509
30MP0002139_abnormal_hepatobiliary_system1.67327553
31MP0001533_abnormal_skeleton_physiology1.65188795
32MP0008438_abnormal_cutaneous_collagen1.65084121
33MP0003300_gastrointestinal_ulcer1.63718924
34MP0009840_abnormal_foam_cell1.61720319
35MP0002132_abnormal_respiratory_system1.59968409
36MP0004808_abnormal_hematopoietic_stem1.59135577
37MP0004957_abnormal_blastocyst_morpholog1.57641737
38MP0001545_abnormal_hematopoietic_system1.57576083
39MP0005397_hematopoietic_system_phenotyp1.57576083
40MP0009278_abnormal_bone_marrow1.53602132
41MP0001730_embryonic_growth_arrest1.53564721
42MP0005023_abnormal_wound_healing1.50098548
43MP0001845_abnormal_inflammatory_respons1.49228329
44MP0003866_abnormal_defecation1.49191766
45MP0004381_abnormal_hair_follicle1.44060429
46MP0000350_abnormal_cell_proliferation1.39813829
47MP0005075_abnormal_melanosome_morpholog1.39025418
48MP0000490_abnormal_crypts_of1.34218038
49MP0004947_skin_inflammation1.33194568
50MP0003984_embryonic_growth_retardation1.32347982
51MP0008469_abnormal_protein_level1.32059891
52MP0003828_pulmonary_edema1.30299276
53MP0005360_urolithiasis1.30163559
54MP0002088_abnormal_embryonic_growth/wei1.29077436
55MP0005380_embryogenesis_phenotype1.27989813
56MP0001672_abnormal_embryogenesis/_devel1.27989813
57MP0005310_abnormal_salivary_gland1.27989101
58MP0003436_decreased_susceptibility_to1.24880338
59MP0001873_stomach_inflammation1.24352632
60MP0003183_abnormal_peptide_metabolism1.21546392
61MP0006054_spinal_hemorrhage1.20190348
62MP0000015_abnormal_ear_pigmentation1.20031518
63MP0005365_abnormal_bile_salt1.19291792
64MP0008058_abnormal_DNA_repair1.17894492
65MP0005275_abnormal_skin_tensile1.17828036
66MP0003303_peritoneal_inflammation1.16974162
67MP0009764_decreased_sensitivity_to1.16805326
68MP0001849_ear_inflammation1.13267814
69MP0002086_abnormal_extraembryonic_tissu1.12522781
70MP0002877_abnormal_melanocyte_morpholog1.12409243
71MP0002138_abnormal_hepatobiliary_system1.10501720
72MP0004197_abnormal_fetal_growth/weight/1.09601360
73MP0000685_abnormal_immune_system1.09347821
74MP0000733_abnormal_muscle_development1.07569950
75MP0003252_abnormal_bile_duct1.07111906
76MP0003191_abnormal_cellular_cholesterol1.06274682
77MP0001915_intracranial_hemorrhage1.05654787
78MP0001853_heart_inflammation1.04922087
79MP0009333_abnormal_splenocyte_physiolog1.04530110
80MP0001958_emphysema1.03337310
81MP0002080_prenatal_lethality1.03108621
82MP0001697_abnormal_embryo_size1.03007810
83MP0002019_abnormal_tumor_incidence1.00858177
84MP0002060_abnormal_skin_morphology0.99372700
85MP0004264_abnormal_extraembryonic_tissu0.97590735
86MP0003567_abnormal_fetal_cardiomyocyte0.97528425
87MP0002398_abnormal_bone_marrow0.95818349
88MP0003763_abnormal_thymus_physiology0.95665265
89MP0004883_abnormal_blood_vessel0.95438559
90MP0002998_abnormal_bone_remodeling0.95387289
91MP0000858_altered_metastatic_potential0.95153869
92MP0002722_abnormal_immune_system0.95029824
93MP0010155_abnormal_intestine_physiology0.93826522
94MP0004185_abnormal_adipocyte_glucose0.93589390
95MP0003075_altered_response_to0.93213927
96MP0010234_abnormal_vibrissa_follicle0.92910128
97MP0000689_abnormal_spleen_morphology0.92834054
98MP0000609_abnormal_liver_physiology0.92404773
99MP0001851_eye_inflammation0.92268872
100MP0000313_abnormal_cell_death0.91977769
101MP0009053_abnormal_anal_canal0.91923880
102MP0000598_abnormal_liver_morphology0.91917939
103MP0010368_abnormal_lymphatic_system0.91014875
104MP0002166_altered_tumor_susceptibility0.89973095
105MP0002405_respiratory_system_inflammati0.88796773
106MP0003091_abnormal_cell_migration0.88344342
107MP0003115_abnormal_respiratory_system0.87819106
108MP0000703_abnormal_thymus_morphology0.87640463
109MP0003453_abnormal_keratinocyte_physiol0.87136697
110MP0003279_aneurysm0.86675667
111MP0005464_abnormal_platelet_physiology0.85692530
112MP0002332_abnormal_exercise_endurance0.85274324
113MP0005164_abnormal_response_to0.84083538
114MP0009763_increased_sensitivity_to0.83726977
115MP0003448_altered_tumor_morphology0.83483732
116MP0001243_abnormal_dermal_layer0.83367003
117MP0008961_abnormal_basal_metabolism0.83073620
118MP0000569_abnormal_digit_pigmentation0.82882844
119MP0010630_abnormal_cardiac_muscle0.82815620
120MP0000604_amyloidosis0.82229657
121MP0003806_abnormal_nucleotide_metabolis0.81904737
122MP0001800_abnormal_humoral_immune0.81812229
123MP0005621_abnormal_cell_physiology0.80941346
124MP0001663_abnormal_digestive_system0.80433086
125MP0002085_abnormal_embryonic_tissue0.80360795
126MP0001835_abnormal_antigen_presentation0.79694992
127MP0003786_premature_aging0.79663905
128MP0010030_abnormal_orbit_morphology0.78976077
129MP0002084_abnormal_developmental_patter0.78539341
130MP0002452_abnormal_antigen_presenting0.77737295
131MP0002429_abnormal_blood_cell0.77715294
132MP0008932_abnormal_embryonic_tissue0.77529737
133MP0005085_abnormal_gallbladder_physiolo0.77447510
134MP0005319_abnormal_enzyme/_coenzyme0.75802988
135MP0004858_abnormal_nervous_system0.73797275
136MP0005058_abnormal_lysosome_morphology0.72860620
137MP0000477_abnormal_intestine_morphology0.72815358
138MP0005083_abnormal_biliary_tract0.72251825
139MP0005390_skeleton_phenotype0.71950309
140MP0009672_abnormal_birth_weight0.71826174
141MP0000465_gastrointestinal_hemorrhage0.71622514
142MP0000716_abnormal_immune_system0.71080054
143MP0009931_abnormal_skin_appearance0.70998919
144MP0005257_abnormal_intraocular_pressure0.70764528
145MP0002933_joint_inflammation0.69295266
146MP0005166_decreased_susceptibility_to0.68334745
147MP0003795_abnormal_bone_structure0.67799191
148MP0003221_abnormal_cardiomyocyte_apopto0.67597392
149MP0005501_abnormal_skin_physiology0.64712618
150MP0002006_tumorigenesis0.64484635
151MP0009765_abnormal_xenobiotic_induced0.64343908
152MP0000343_altered_response_to0.63587766
153MP0000249_abnormal_blood_vessel0.62790948
154MP0002970_abnormal_white_adipose0.60954417
155MP0005584_abnormal_enzyme/coenzyme_acti0.60389019

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)5.60170879
2Recurrent abscess formation (HP:0002722)4.82230062
3Recurrent bacterial skin infections (HP:0005406)4.80353354
4Abnormality of macrophages (HP:0004311)4.15903976
5Myositis (HP:0100614)4.11221022
6Abnormality of the heme biosynthetic pathway (HP:0010472)4.10705578
7Hypochromic anemia (HP:0001931)4.06233215
8Elevated erythrocyte sedimentation rate (HP:0003565)3.94709987
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.69753270
10Chronic obstructive pulmonary disease (HP:0006510)3.60452262
11Obstructive lung disease (HP:0006536)3.60452262
12Recurrent fungal infections (HP:0002841)3.58547875
13Orchitis (HP:0100796)3.45994482
14Recurrent gram-negative bacterial infections (HP:0005420)3.44008992
15Stomatitis (HP:0010280)3.38167870
16Urticaria (HP:0001025)3.33801358
17Cerebral aneurysm (HP:0004944)3.27996897
18Mediastinal lymphadenopathy (HP:0100721)3.25451981
19Increased IgE level (HP:0003212)3.19626512
20Prolonged bleeding time (HP:0003010)3.19348982
21Meningitis (HP:0001287)3.18522252
22Microcytic anemia (HP:0001935)3.16866881
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.10556434
24Gastrointestinal infarctions (HP:0005244)3.10311085
25Recurrent skin infections (HP:0001581)3.09949812
26Gastrointestinal inflammation (HP:0004386)3.04757382
27Protrusio acetabuli (HP:0003179)3.01612624
28Cellulitis (HP:0100658)2.99815991
29Inflammation of the large intestine (HP:0002037)2.94991157
30Retrobulbar optic neuritis (HP:0100654)2.89996255
31Optic neuritis (HP:0100653)2.89996255
32Gingivitis (HP:0000230)2.89932324
33Epistaxis (HP:0000421)2.80311997
34Recurrent cutaneous fungal infections (HP:0011370)2.75827901
35Chronic mucocutaneous candidiasis (HP:0002728)2.75827901
36Abnormality of liposaccharide metabolism (HP:0010968)2.71147440
37Abnormality of glycosphingolipid metabolism (HP:0004343)2.71147440
38Abnormality of glycolipid metabolism (HP:0010969)2.71147440
39Vasculitis (HP:0002633)2.67613330
40Spontaneous hematomas (HP:0007420)2.64707842
41Encephalitis (HP:0002383)2.63670210
42T lymphocytopenia (HP:0005403)2.63530471
43Abnormality of the fingertips (HP:0001211)2.60510660
44Premature rupture of membranes (HP:0001788)2.58122786
45Colitis (HP:0002583)2.56678884
46Chest pain (HP:0100749)2.55246198
47Panhypogammaglobulinemia (HP:0003139)2.54486010
48Selective tooth agenesis (HP:0001592)2.52402825
49Increased serum ferritin (HP:0003281)2.51734843
50High pitched voice (HP:0001620)2.49382888
51Ulnar bowing (HP:0003031)2.44822928
52Abnormality of T cell number (HP:0011839)2.42267675
53Slow saccadic eye movements (HP:0000514)2.39986331
54Increased connective tissue (HP:0009025)2.39073713
55Degeneration of anterior horn cells (HP:0002398)2.38514187
56Abnormality of the anterior horn cell (HP:0006802)2.38514187
57Hyperacusis (HP:0010780)2.38315337
58Granulocytopenia (HP:0001913)2.37671395
59Autoimmune thrombocytopenia (HP:0001973)2.36543272
60Osteolytic defects of the hand bones (HP:0009699)2.35271221
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.35271221
62Abnormality of T cells (HP:0002843)2.33573047
63Increased cerebral lipofuscin (HP:0011813)2.30750195
64Purpura (HP:0000979)2.30218309
65Cholelithiasis (HP:0001081)2.26146186
66Abnormality of iron homeostasis (HP:0011031)2.25894495
67Amyloidosis (HP:0011034)2.23179087
68Agammaglobulinemia (HP:0004432)2.22542543
69Polycythemia (HP:0001901)2.22289593
70Thin bony cortex (HP:0002753)2.19517547
71Leukocytosis (HP:0001974)2.16944961
72Abnormality of the nasal mucosa (HP:0000433)2.16641388
73Episodic fever (HP:0001954)2.13992052
74Keratoconjunctivitis sicca (HP:0001097)2.13760223
75Increased IgM level (HP:0003496)2.11668641
76Shallow orbits (HP:0000586)2.11065591
77Increased neuronal autofluorescent lipopigment (HP:0002074)2.11031388
78Hypertriglyceridemia (HP:0002155)2.10581740
79Increased density of long bones (HP:0006392)2.10459544
80Pulmonary infiltrates (HP:0002113)2.10455735
81Osteomyelitis (HP:0002754)2.08100932
82Cervical subluxation (HP:0003308)2.08066589
83Thrombocytosis (HP:0001894)2.08057107
84Nasal polyposis (HP:0100582)2.07975054
85Loss of speech (HP:0002371)2.07685712
86Lymphopenia (HP:0001888)2.05320414
87Hypertensive crisis (HP:0100735)2.04944234
88Increased mean platelet volume (HP:0011877)2.03989730
89Aortic aneurysm (HP:0004942)2.03795975
90Aneurysm (HP:0002617)2.03564230
91Dysostosis multiplex (HP:0000943)2.02549619
92Abnormality of T cell physiology (HP:0011840)2.01140626
93Deep venous thrombosis (HP:0002625)2.00810237
94Verrucae (HP:0200043)1.99913922
95Papilloma (HP:0012740)1.99913922
96Autoimmune hemolytic anemia (HP:0001890)1.98857997
97Abnormal platelet volume (HP:0011876)1.98275281
98Myocardial infarction (HP:0001658)1.97651100
99Peritonitis (HP:0002586)1.97222347
100Interstitial pulmonary disease (HP:0006530)1.96362079
101Hypergammaglobulinemia (HP:0010702)1.96230388
102Arterial thrombosis (HP:0004420)1.95783430
103Abnormality of polysaccharide metabolism (HP:0011012)1.95180890
104Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95180890
105Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95180890
106Recurrent viral infections (HP:0004429)1.95165054
107Ragged-red muscle fibers (HP:0003200)1.94695274
108Abnormality of cells of the lymphoid lineage (HP:0012140)1.93558380
109Difficulty climbing stairs (HP:0003551)1.92864002
110Abnormality of monocarboxylic acid metabolism (HP:0010996)1.92070197
111Skin ulcer (HP:0200042)1.92063907
112Hepatosplenomegaly (HP:0001433)1.91759162
113Hemoptysis (HP:0002105)1.91547817
114Toxemia of pregnancy (HP:0100603)1.91268516
115Abnormal gallbladder morphology (HP:0012437)1.91000190
116Keratoconjunctivitis (HP:0001096)1.90803237
117Eczematoid dermatitis (HP:0000976)1.89612202
118Pustule (HP:0200039)1.89088138
119Genu recurvatum (HP:0002816)1.86742974
120Upper limb amyotrophy (HP:0009129)1.86512965
121Distal upper limb amyotrophy (HP:0007149)1.86512965
122Sepsis (HP:0100806)1.86290716
123Vertebral compression fractures (HP:0002953)1.86169459
124Cholecystitis (HP:0001082)1.86031078
125Abnormal gallbladder physiology (HP:0012438)1.86031078
126Ankle contracture (HP:0006466)1.85776894
127Hand muscle atrophy (HP:0009130)1.85005564
128Anorexia (HP:0002039)1.84759038
129Abnormality of the peritoneum (HP:0002585)1.84279720
130Prominent nose (HP:0000448)1.83815458
131Long toe (HP:0010511)1.83746658
132Abnormality of transition element cation homeostasis (HP:0011030)1.83707774
133Ependymoma (HP:0002888)1.83339921
134Abnormal hemoglobin (HP:0011902)1.82912679
135Increased nuchal translucency (HP:0010880)1.82667615
136Gastrointestinal stroma tumor (HP:0100723)1.82587406
137Urethral obstruction (HP:0000796)1.81184720
138Broad palm (HP:0001169)1.78950985
139Reticulocytosis (HP:0001923)1.76438722
140Dilatation of the ascending aorta (HP:0005111)1.74914886
141Renovascular hypertension (HP:0100817)1.74333409
142Subacute progressive viral hepatitis (HP:0006572)1.73015187
143Impulsivity (HP:0100710)1.72816830
144Esophageal varix (HP:0002040)1.72384371
145Lip pit (HP:0100267)1.72264321
146Nonimmune hydrops fetalis (HP:0001790)1.70205326
147Renal duplication (HP:0000075)1.69551794
148Long eyelashes (HP:0000527)1.68751949
149Bicuspid aortic valve (HP:0001647)1.68489982
150Bladder diverticulum (HP:0000015)1.63307059
151Disproportionate tall stature (HP:0001519)1.62642034
152Mitral valve prolapse (HP:0001634)1.60250777
153Short nail (HP:0001799)1.58784880
154Bowel diverticulosis (HP:0005222)1.57644869
155Bowed forearm bones (HP:0003956)1.56309322
156Bowing of the arm (HP:0006488)1.56309322
157Hematochezia (HP:0002573)1.55846446
158Flat acetabular roof (HP:0003180)1.55711149
159Periodontitis (HP:0000704)1.55674614
160Spastic diplegia (HP:0001264)1.55378800
161Radial bowing (HP:0002986)1.55246376
162Deviation of the thumb (HP:0009603)1.54705733
163Hallux valgus (HP:0001822)1.53176499
164Abnormality of the acetabulum (HP:0003170)1.52695778
165Right ventricular cardiomyopathy (HP:0011663)1.52523072
166Abnormality of the lower motor neuron (HP:0002366)1.52381644
167Ulnar deviation of the wrist (HP:0003049)1.52045837
168Heterotopia (HP:0002282)1.49871715
169Deviation of the hallux (HP:0010051)1.49635789
170Gingival bleeding (HP:0000225)1.49142612
171Conjunctival telangiectasia (HP:0000524)1.48630911
172Squamous cell carcinoma (HP:0002860)1.47956397
173Abnormality of pyrimidine metabolism (HP:0004353)1.47871514
174Gastrointestinal carcinoma (HP:0002672)1.47249280
175Malignant gastrointestinal tract tumors (HP:0006749)1.47249280
176Multiple enchondromatosis (HP:0005701)1.47238498
177Abnormality of the gastric mucosa (HP:0004295)1.45358358
178Biconcave vertebral bodies (HP:0004586)1.45355069
179Abnormality of the calcaneus (HP:0008364)1.44492557
180Slender long bone (HP:0003100)1.43095973
181Distal lower limb amyotrophy (HP:0008944)1.42614733
182Abnormal platelet function (HP:0011869)1.40683466
183Impaired platelet aggregation (HP:0003540)1.40683466
184Skin tags (HP:0010609)1.40063501
185Proximal placement of thumb (HP:0009623)1.39895392
186Elfin facies (HP:0004428)1.39661721
187Metaphyseal cupping (HP:0003021)1.39427461
188Persistence of primary teeth (HP:0006335)1.38139298
189Petechiae (HP:0000967)1.38119868
190Cutaneous melanoma (HP:0012056)1.37713026
191Entropion (HP:0000621)1.37623300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.84247292
2PKN23.13246360
3RIPK43.12033675
4CDK123.02269068
5ERN12.78779096
6EEF2K2.52503421
7NEK22.37014661
8MAP3K102.29425620
9IRAK42.26922505
10MAP4K12.25592722
11PRPF4B2.09658123
12STK31.92203224
13STK101.86853855
14CDC71.85554283
15TNK21.85020909
16TTN1.84800669
17PTK61.75680750
18FES1.70462531
19IKBKE1.65163376
20SMG11.64700894
21FGR1.58127871
22TTK1.56683287
23LRRK21.53666977
24MAP2K31.50484512
25TESK11.46251053
26TXK1.45174795
27RPS6KA41.43891664
28FGFR41.43559401
29MAP3K131.41772312
30BUB11.40833541
31ZAP701.38667124
32SCYL21.38447325
33SIK31.37079108
34PAK41.36746277
35SYK1.35597628
36MAP3K11.34891863
37CDK41.34730302
38HCK1.30035958
39MTOR1.27760424
40NEK91.25793267
41SIK11.25367636
42ICK1.21563152
43MAP3K81.20538022
44STK41.20318724
45TAOK21.20159356
46WEE11.19958147
47CDK61.17274562
48JAK31.16240872
49PRKD21.14199666
50TBK11.12494505
51TYK21.10990341
52TESK21.09025740
53PASK1.07963896
54RPS6KB21.00648269
55MARK21.00147562
56LYN0.99610062
57ATR0.97185998
58IKBKB0.97156773
59LATS10.97110924
60PIM20.97048448
61PIM10.96741012
62MARK30.96289974
63PTK2B0.93613703
64KSR20.92193581
65EPHA20.91751925
66PAK20.91042594
67LCK0.90996210
68PDK40.89149965
69PDK30.89149965
70ALK0.88516037
71EIF2AK10.86750554
72RIPK10.86550322
73PDGFRA0.86288533
74PLK10.86145500
75CHEK10.86062053
76AURKB0.85824520
77NEK10.85656337
78CHUK0.84828500
79CDK70.83943436
80BRD40.82300076
81BMX0.80234022
82CDC42BPA0.80189278
83FLT30.79213670
84SIK20.77744239
85CLK10.75284046
86EPHB10.74016823
87TSSK60.70904862
88TGFBR20.70177925
89TAOK10.68715830
90MAP3K30.68048113
91FGFR10.66496520
92MATK0.66267955
93PDK10.66167584
94HIPK20.65633177
95PDPK10.65284076
96NME20.64538675
97TGFBR10.63928185
98KIT0.63658734
99CSF1R0.62598974
100DYRK1B0.62312319
101PIK3CG0.62031061
102BTK0.61789123
103PTK20.60891774
104MAP3K70.59715251
105DDR20.57807876
106JAK10.57760059
107MAPKAPK20.57372769
108BRSK20.56084395
109TRPM70.55436935
110FGFR30.55363947
111MAP3K110.54786019
112PDGFRB0.53538431
113MAPKAPK30.53187349
114CDK20.52584734
115IRAK10.51857164
116CSK0.51066570
117STK380.51040690
118MAPK110.51039628
119BCKDK0.50737648
120TAOK30.50329366
121MAP3K60.50216664
122IRAK30.49630393
123MAP2K20.49234001
124KDR0.49156283
125MAP3K140.48855848
126RPS6KC10.48744979
127RPS6KL10.48744979
128ATM0.48624693
129DYRK30.48622687
130BLK0.48611869
131ITK0.48307908
132GRK60.47493330
133STK240.47284513
134CHEK20.47239081
135JAK20.46755012
136MAP3K50.46518047
137RAF10.45651497
138MAPK120.45596129
139PAK10.44686288
140IRAK20.44598936
141CAMK1D0.43507506
142MAP3K20.39616807
143RPS6KA60.36872805
144ARAF0.35006041
145TEC0.34423675
146YES10.34007336
147GRK50.33707580

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006702.53893140
2DNA replication_Homo sapiens_hsa030302.51202066
3Other glycan degradation_Homo sapiens_hsa005112.37494587
4Selenocompound metabolism_Homo sapiens_hsa004502.24836526
5Allograft rejection_Homo sapiens_hsa053302.04332567
6Graft-versus-host disease_Homo sapiens_hsa053322.03095252
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.02597740
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.98077722
9Malaria_Homo sapiens_hsa051441.97156121
10Autoimmune thyroid disease_Homo sapiens_hsa053201.93183950
11Tuberculosis_Homo sapiens_hsa051521.76993702
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71989249
13T cell receptor signaling pathway_Homo sapiens_hsa046601.71353801
14Base excision repair_Homo sapiens_hsa034101.68508127
15RNA transport_Homo sapiens_hsa030131.64436657
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62040998
17Hematopoietic cell lineage_Homo sapiens_hsa046401.59611705
18Cell cycle_Homo sapiens_hsa041101.59522875
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56962452
20Mismatch repair_Homo sapiens_hsa034301.44471717
21Small cell lung cancer_Homo sapiens_hsa052221.43560003
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41645689
23Antigen processing and presentation_Homo sapiens_hsa046121.41329360
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.40807945
25Lysine degradation_Homo sapiens_hsa003101.40697542
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40376392
27Pentose phosphate pathway_Homo sapiens_hsa000301.36780787
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36584827
29Spliceosome_Homo sapiens_hsa030401.33820286
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32539251
31Chronic myeloid leukemia_Homo sapiens_hsa052201.31043083
32p53 signaling pathway_Homo sapiens_hsa041151.30984299
33Type I diabetes mellitus_Homo sapiens_hsa049401.28830480
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.26584353
35Hepatitis C_Homo sapiens_hsa051601.26402763
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26176942
37Biosynthesis of amino acids_Homo sapiens_hsa012301.21806490
38Chemokine signaling pathway_Homo sapiens_hsa040621.20296668
39Asthma_Homo sapiens_hsa053101.18559086
40Legionellosis_Homo sapiens_hsa051341.16372987
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.16208423
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13614264
43Lysosome_Homo sapiens_hsa041421.11827044
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.10709872
45VEGF signaling pathway_Homo sapiens_hsa043701.10244169
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10118249
47Herpes simplex infection_Homo sapiens_hsa051681.07902286
48Galactose metabolism_Homo sapiens_hsa000521.04789281
49Homologous recombination_Homo sapiens_hsa034401.04681893
50Phagosome_Homo sapiens_hsa041451.01393193
51Apoptosis_Homo sapiens_hsa042101.01343132
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00519030
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00220540
54African trypanosomiasis_Homo sapiens_hsa051431.00119399
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.99467425
56Toxoplasmosis_Homo sapiens_hsa051450.99212692
57Viral carcinogenesis_Homo sapiens_hsa052030.98981362
58Leishmaniasis_Homo sapiens_hsa051400.97480577
59Caffeine metabolism_Homo sapiens_hsa002320.97062426
60Acute myeloid leukemia_Homo sapiens_hsa052210.96894022
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96431004
62Measles_Homo sapiens_hsa051620.96084747
63Sulfur relay system_Homo sapiens_hsa041220.95940275
64Carbon metabolism_Homo sapiens_hsa012000.95614464
65Platelet activation_Homo sapiens_hsa046110.95095775
66HTLV-I infection_Homo sapiens_hsa051660.94837233
67MicroRNAs in cancer_Homo sapiens_hsa052060.94164761
68Non-homologous end-joining_Homo sapiens_hsa034500.93312980
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93277790
70Salmonella infection_Homo sapiens_hsa051320.92531188
71mRNA surveillance pathway_Homo sapiens_hsa030150.91516431
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.90440982
73Fatty acid degradation_Homo sapiens_hsa000710.87650377
74Bladder cancer_Homo sapiens_hsa052190.87127559
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87070781
76Adherens junction_Homo sapiens_hsa045200.86983972
77Epstein-Barr virus infection_Homo sapiens_hsa051690.86070838
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.85520245
79Prolactin signaling pathway_Homo sapiens_hsa049170.84040755
80Nucleotide excision repair_Homo sapiens_hsa034200.82279526
81Viral myocarditis_Homo sapiens_hsa054160.82151041
82Pertussis_Homo sapiens_hsa051330.81843779
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80872456
84Influenza A_Homo sapiens_hsa051640.80197961
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79946079
86Fructose and mannose metabolism_Homo sapiens_hsa000510.79549343
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.77728466
88Endocytosis_Homo sapiens_hsa041440.77717985
89Proteoglycans in cancer_Homo sapiens_hsa052050.76218109
90Fanconi anemia pathway_Homo sapiens_hsa034600.75665093
91Complement and coagulation cascades_Homo sapiens_hsa046100.75613901
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.74769744
93B cell receptor signaling pathway_Homo sapiens_hsa046620.74536002
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.74194879
95Hepatitis B_Homo sapiens_hsa051610.72770414
96Staphylococcus aureus infection_Homo sapiens_hsa051500.71581578
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70813852
98ABC transporters_Homo sapiens_hsa020100.70514746
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70444469
100Renal cell carcinoma_Homo sapiens_hsa052110.70443161
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.70421509
102Shigellosis_Homo sapiens_hsa051310.70299089
103Endometrial cancer_Homo sapiens_hsa052130.70078747
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68467910
105Insulin resistance_Homo sapiens_hsa049310.68137128
106Vitamin B6 metabolism_Homo sapiens_hsa007500.67722961
107Thyroid cancer_Homo sapiens_hsa052160.67663610
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67320753
109Rheumatoid arthritis_Homo sapiens_hsa053230.66065836
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.65526407
111HIF-1 signaling pathway_Homo sapiens_hsa040660.65522118
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64758946
113Osteoclast differentiation_Homo sapiens_hsa043800.64625884
114mTOR signaling pathway_Homo sapiens_hsa041500.64378579
115Renin-angiotensin system_Homo sapiens_hsa046140.63937128
116Pancreatic cancer_Homo sapiens_hsa052120.63677223
117Tryptophan metabolism_Homo sapiens_hsa003800.62712772
118Pyrimidine metabolism_Homo sapiens_hsa002400.62234298
119TNF signaling pathway_Homo sapiens_hsa046680.61275990
120PPAR signaling pathway_Homo sapiens_hsa033200.60335622
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.60254499
122Inositol phosphate metabolism_Homo sapiens_hsa005620.60008806
123Notch signaling pathway_Homo sapiens_hsa043300.59646121
124Focal adhesion_Homo sapiens_hsa045100.59611941
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59194031
126Non-small cell lung cancer_Homo sapiens_hsa052230.58691894
127FoxO signaling pathway_Homo sapiens_hsa040680.58369519
128Fat digestion and absorption_Homo sapiens_hsa049750.57819284
129ECM-receptor interaction_Homo sapiens_hsa045120.57570746
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56512539
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56281752
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56038689
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.55487953
134Glutathione metabolism_Homo sapiens_hsa004800.55381546
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.55118074
136Starch and sucrose metabolism_Homo sapiens_hsa005000.54903839
137Folate biosynthesis_Homo sapiens_hsa007900.51864998
138Insulin signaling pathway_Homo sapiens_hsa049100.51701580
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51556751
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51031454
141Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50294491
142Choline metabolism in cancer_Homo sapiens_hsa052310.50159750
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49002766
144Amoebiasis_Homo sapiens_hsa051460.48878657
145Primary immunodeficiency_Homo sapiens_hsa053400.48693997
146Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48312432
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47745748
148Intestinal immune network for IgA production_Homo sapiens_hsa046720.47503248
149Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45161725
150Regulation of autophagy_Homo sapiens_hsa041400.41836994
151Phospholipase D signaling pathway_Homo sapiens_hsa040720.41176499
152Prostate cancer_Homo sapiens_hsa052150.40980433
153Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39806439

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