ASCC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.82536164
2nuclear pore complex assembly (GO:0051292)4.81838451
3Golgi transport vesicle coating (GO:0048200)4.71683195
4COPI coating of Golgi vesicle (GO:0048205)4.71683195
5negative regulation of DNA repair (GO:0045738)4.41421712
6nuclear pore organization (GO:0006999)4.19236452
7DNA unwinding involved in DNA replication (GO:0006268)4.13952369
8hemidesmosome assembly (GO:0031581)4.11186921
9protein localization to chromosome, centromeric region (GO:0071459)3.93725537
10sister chromatid segregation (GO:0000819)3.77518412
11mitotic chromosome condensation (GO:0007076)3.73486033
12cytoplasmic mRNA processing body assembly (GO:0033962)3.72554820
13pre-miRNA processing (GO:0031054)3.68477663
14protein localization to kinetochore (GO:0034501)3.65717877
15regulation of centriole replication (GO:0046599)3.63493638
16paraxial mesoderm development (GO:0048339)3.58038627
17mitotic sister chromatid segregation (GO:0000070)3.57631313
18COPII vesicle coating (GO:0048208)3.54690071
19mitotic sister chromatid cohesion (GO:0007064)3.51872610
20pore complex assembly (GO:0046931)3.47041592
21* DNA duplex unwinding (GO:0032508)3.42193829
22non-recombinational repair (GO:0000726)3.40423300
23double-strand break repair via nonhomologous end joining (GO:0006303)3.40423300
24mitotic nuclear envelope disassembly (GO:0007077)3.40286481
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.38761440
26positive regulation of RNA splicing (GO:0033120)3.31283996
27* DNA geometric change (GO:0032392)3.31150936
28mitotic metaphase plate congression (GO:0007080)3.29159116
29nuclear envelope disassembly (GO:0051081)3.26789865
30membrane disassembly (GO:0030397)3.26789865
31positive regulation of gamma-delta T cell activation (GO:0046645)3.17422916
32regulation of translational fidelity (GO:0006450)3.15668707
33metaphase plate congression (GO:0051310)3.15384871
34NLS-bearing protein import into nucleus (GO:0006607)3.11365832
35activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.05162235
36heterochromatin organization (GO:0070828)3.04752277
37antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.04366333
38antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.04366333
39ribosome assembly (GO:0042255)3.01731142
40folic acid-containing compound biosynthetic process (GO:0009396)3.00863985
41retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.00324201
42macroautophagy (GO:0016236)2.98702235
43positive regulation of chromosome segregation (GO:0051984)2.98354860
44cellular protein complex localization (GO:0034629)2.96697305
45regulation of chromosome segregation (GO:0051983)2.96520586
46regulation of transforming growth factor beta2 production (GO:0032909)2.96199266
47growth hormone receptor signaling pathway (GO:0060396)2.95482371
48positive regulation of nuclease activity (GO:0032075)2.95233427
49regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94464038
50regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94464038
51monoubiquitinated protein deubiquitination (GO:0035520)2.94040303
52regulation of nucleobase-containing compound transport (GO:0032239)2.92979110
53establishment of chromosome localization (GO:0051303)2.92925384
54regulation of centrosome duplication (GO:0010824)2.90101259
55endoplasmic reticulum unfolded protein response (GO:0030968)2.89240066
56DNA topological change (GO:0006265)2.88440390
57UDP-N-acetylglucosamine metabolic process (GO:0006047)2.87346267
58cell-substrate junction assembly (GO:0007044)2.86875802
59negative regulation of chromosome segregation (GO:0051985)2.86846494
60spindle checkpoint (GO:0031577)2.86392081
61regulation of centrosome cycle (GO:0046605)2.86354782
62negative regulation of keratinocyte proliferation (GO:0010839)2.86254865
63regulation of mitotic sister chromatid segregation (GO:0033047)2.85971305
64regulation of sister chromatid segregation (GO:0033045)2.85971305
65regulation of mitotic sister chromatid separation (GO:0010965)2.85971305
66positive regulation of interferon-alpha production (GO:0032727)2.85631351
67cellular response to unfolded protein (GO:0034620)2.84347147
68maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.84289365
69protein complex localization (GO:0031503)2.83250988
70cellular response to interferon-alpha (GO:0035457)2.83034347
71regulation of nuclease activity (GO:0032069)2.82172571
72regulation of DNA endoreduplication (GO:0032875)2.82153355
73negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.80157989
74negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.80157989
75negative regulation of mitotic sister chromatid segregation (GO:0033048)2.80157989
76negative regulation of mitotic sister chromatid separation (GO:2000816)2.80157989
77negative regulation of sister chromatid segregation (GO:0033046)2.80157989
78cell adhesion mediated by integrin (GO:0033627)2.79930992
79regulation of protein polyubiquitination (GO:1902914)2.79321422
80DNA strand elongation involved in DNA replication (GO:0006271)2.79279658
81modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.78806882
82positive regulation by organism of defense response of other organism involved in symbiotic interact2.78806882
83modulation by symbiont of host immune response (GO:0052553)2.78806882
84positive regulation by symbiont of host defense response (GO:0052509)2.78806882
85modulation by symbiont of host defense response (GO:0052031)2.78806882
86modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.78806882
87DNA replication initiation (GO:0006270)2.78565666
88mitotic spindle checkpoint (GO:0071174)2.78063413
89response to interferon-alpha (GO:0035455)2.77563235
90positive regulation of SMAD protein import into nucleus (GO:0060391)2.76389052
91gonadal mesoderm development (GO:0007506)2.75641097
92L-alpha-amino acid transmembrane transport (GO:1902475)2.74659772
93hippo signaling (GO:0035329)2.74569519
94regulation of interferon-alpha production (GO:0032647)2.73775545
95antigen processing and presentation of endogenous antigen (GO:0019883)2.73746209
96DNA strand elongation (GO:0022616)2.73495343
97mitotic cytokinesis (GO:0000281)2.73295191
98mitotic spindle assembly checkpoint (GO:0007094)2.72962922
99intestinal epithelial cell development (GO:0060576)2.71957694
100* DNA conformation change (GO:0071103)2.71613627
101establishment of integrated proviral latency (GO:0075713)2.70703458
102mitochondrial DNA metabolic process (GO:0032042)2.70598781
103spindle assembly checkpoint (GO:0071173)2.69923672
104negative regulation of B cell proliferation (GO:0030889)2.69152983
105DNA synthesis involved in DNA repair (GO:0000731)2.66548489
106response to X-ray (GO:0010165)2.65105708
107regulation of spindle organization (GO:0090224)2.64991114
108regulation of histone H3-K9 methylation (GO:0051570)2.64568811
109nuclear envelope organization (GO:0006998)2.63088406
110exocrine pancreas development (GO:0031017)2.62345429
111histone mRNA catabolic process (GO:0071044)2.62324380
112negative regulation of fibroblast apoptotic process (GO:2000270)2.61812243
113endodermal cell differentiation (GO:0035987)2.60710829
114protein export from nucleus (GO:0006611)2.60182382
115JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.59829286
116ER-nucleus signaling pathway (GO:0006984)2.59737774
117cellular response to topologically incorrect protein (GO:0035967)2.58787087
118positive regulation of interferon-beta production (GO:0032728)2.57212450
119regulation of RNA export from nucleus (GO:0046831)2.57097270
120bundle of His cell to Purkinje myocyte communication (GO:0086069)2.55868275
121positive regulation of p38MAPK cascade (GO:1900745)2.55810470
122histone-serine phosphorylation (GO:0035404)2.55354314
123natural killer cell mediated immunity (GO:0002228)2.55333386
124natural killer cell mediated cytotoxicity (GO:0042267)2.55333386
125desmosome organization (GO:0002934)2.55149729
126sequestering of metal ion (GO:0051238)2.52255198
127antigen processing and presentation via MHC class Ib (GO:0002475)2.51538070
128sister chromatid cohesion (GO:0007062)2.50674087
129cytoskeleton-dependent cytokinesis (GO:0061640)2.50151756
130positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.49902806
131CENP-A containing nucleosome assembly (GO:0034080)2.49867207
132positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.49859233
133positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.49859233
134positive regulation of mitotic sister chromatid separation (GO:1901970)2.49859233
135regulation of double-strand break repair (GO:2000779)2.49460507
136chromatin assembly (GO:0031497)2.48991828
137type B pancreatic cell development (GO:0003323)2.48856643
138mitotic G2/M transition checkpoint (GO:0044818)2.48828662
139notochord development (GO:0030903)2.48429954
140regulation of interleukin-12 biosynthetic process (GO:0045075)2.48117827
141cellular response to growth hormone stimulus (GO:0071378)2.46249924
142positive regulation of cell cycle checkpoint (GO:1901978)2.45447147
143positive regulation of histone deacetylation (GO:0031065)2.45199621
144chromosome condensation (GO:0030261)2.44877086
145regulation of mitotic spindle organization (GO:0060236)2.44424104
146gap junction assembly (GO:0016264)2.43882362
147positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.43170519
148I-kappaB phosphorylation (GO:0007252)2.43072728
149iron ion import (GO:0097286)2.37241092
150histone H3-K36 demethylation (GO:0070544)2.35784476
151apoptotic cell clearance (GO:0043277)2.35507488
152tetrahydrofolate metabolic process (GO:0046653)2.33346001
153histone H3-K9 demethylation (GO:0033169)2.33033659
154dosage compensation (GO:0007549)2.32751620
155regulation of sister chromatid cohesion (GO:0007063)2.31899734
156regulation of interferon-beta biosynthetic process (GO:0045357)2.31539727
157regulation of gamma-delta T cell activation (GO:0046643)2.31184177
158intestinal cholesterol absorption (GO:0030299)2.28268691
159response to endoplasmic reticulum stress (GO:0034976)2.27887730
160early endosome to late endosome transport (GO:0045022)2.27434491
161vesicle coating (GO:0006901)2.26769563
162positive regulation of mRNA metabolic process (GO:1903313)2.24814857
163regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.23512669
164insulin-like growth factor receptor signaling pathway (GO:0048009)2.23509197
165stress granule assembly (GO:0034063)2.21859567
166regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.21670009
167regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.20826463
168keratan sulfate catabolic process (GO:0042340)2.20323544
169positive regulation of mRNA processing (GO:0050685)2.20269277
170protein retention in ER lumen (GO:0006621)2.19947056
171columnar/cuboidal epithelial cell development (GO:0002066)2.19726708
172lung vasculature development (GO:0060426)2.19501365
173Golgi organization (GO:0007030)2.18889234
174response to type I interferon (GO:0034340)2.18618291
175positive regulation of DNA-templated transcription, initiation (GO:2000144)2.17992319
176endocrine pancreas development (GO:0031018)2.17317391
177positive regulation of natural killer cell differentiation (GO:0032825)2.16855129
178signal peptide processing (GO:0006465)2.14708534
179positive regulation of hormone biosynthetic process (GO:0046886)2.14496230
180glandular epithelial cell development (GO:0002068)2.12963503
181cellular response to vitamin D (GO:0071305)2.12740733
182positive regulation of catenin import into nucleus (GO:0035413)2.11997936
183positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.11787306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.96733791
2E2F7_22180533_ChIP-Seq_HELA_Human4.67793764
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.38273566
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.27296456
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.52413686
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.40906541
7GATA1_22025678_ChIP-Seq_K562_Human3.17819760
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.07054672
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.71115323
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.54573433
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.52950723
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.37668358
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.34659381
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.33621563
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31926937
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18992083
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.16003596
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15174584
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.12648851
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.03460958
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01644603
22* IRF8_27001747_Chip-Seq_BMDM_Mouse1.97289383
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.87802762
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.87657928
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.84658155
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.80918109
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75260178
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68392934
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.68077963
30BRD4_25478319_ChIP-Seq_HGPS_Human1.62439250
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61503090
32CLOCK_20551151_ChIP-Seq_293T_Human1.60909182
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58431720
34FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.57987027
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57169158
36SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54437221
37ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53453818
38MYB_26560356_Chip-Seq_TH2_Human1.52489597
39* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52463154
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.52309071
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.51561308
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50224069
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47396216
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46017729
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45223411
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42155356
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40072306
48MYB_26560356_Chip-Seq_TH1_Human1.39939195
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.38782637
50RXR_22158963_ChIP-Seq_LIVER_Mouse1.37309302
51TFEB_21752829_ChIP-Seq_HELA_Human1.37028195
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36695179
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36209710
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36209710
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32981855
56CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32848550
57AR_21909140_ChIP-Seq_LNCAP_Human1.29547042
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.29272208
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29083627
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.27939537
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.27548572
62* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27218813
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25832096
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25811206
65SOX17_20123909_ChIP-Seq_XEN_Mouse1.25703086
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25335273
67GATA6_25053715_ChIP-Seq_YYC3_Human1.24878215
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.23502710
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23460760
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.22751544
71ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.22349280
72* PU_27001747_Chip-Seq_BMDM_Mouse1.22272188
73FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21859344
74MYC_22102868_ChIP-Seq_BL_Human1.20488078
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19571866
76FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.16170783
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16168980
78ELK1_19687146_ChIP-ChIP_HELA_Human1.15384232
79PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15338795
80EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.13864681
81CHD1_26751641_Chip-Seq_LNCaP_Human1.12851536
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12036612
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12009444
84DCP1A_22483619_ChIP-Seq_HELA_Human1.11997108
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.11956487
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11518374
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11081255
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10683447
89EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10060749
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08877570
91FUS_26573619_Chip-Seq_HEK293_Human1.08805596
92FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.08682105
93GATA3_27048872_Chip-Seq_THYMUS_Human1.08112800
94SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07833518
95GATA4_25053715_ChIP-Seq_YYC3_Human1.07146581
96CJUN_26792858_Chip-Seq_BT549_Human1.06095514
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05972121
98SCL_19346495_ChIP-Seq_HPC-7_Human1.05747503
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05627599
100* EWS_26573619_Chip-Seq_HEK293_Human1.04461775
101STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04333232
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02542945
103CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01498504
104FOXA2_19822575_ChIP-Seq_HepG2_Human1.01348973
105MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00708517
106TP53_16413492_ChIP-PET_HCT116_Human1.00253911
107SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00092763
108RUNX_20019798_ChIP-Seq_JUKART_Human0.99615273
109NANOG_16153702_ChIP-ChIP_HESCs_Human0.98920057
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97084996
111E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96627488
112* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95849611
113* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95191245
114CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95137164
115PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94166153
116HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93356169
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92721292
118FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92639986
119GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92585279
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92395261
121* TP53_18474530_ChIP-ChIP_U2OS_Human0.90755528
122EP300_21415370_ChIP-Seq_HL-1_Mouse0.89791726
123CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89488044
124* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89230934
125WT1_19549856_ChIP-ChIP_CCG9911_Human0.89130523
126NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88703125
127TCF7_22412390_ChIP-Seq_EML_Mouse0.88548874
128KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88473183
129KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88155911
130ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.87358932
131NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86582665
132DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86560344
133NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85966851
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85966851
135* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85965542
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85950541
137MYC_18358816_ChIP-ChIP_MESCs_Mouse0.85829194
138* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85745564
139SOX2_20726797_ChIP-Seq_SW620_Human0.85698068
140SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84591011
141E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84581810
142NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84401694
143HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83978529
144NOTCH1_21737748_ChIP-Seq_TLL_Human0.83282016
145FOXA1_25552417_ChIP-Seq_VCAP_Human0.83202952
146TBX3_20139965_ChIP-Seq_ESCs_Mouse0.82537495
147GATA4_21415370_ChIP-Seq_HL-1_Mouse0.82114772
148HIF1A_21447827_ChIP-Seq_MCF-7_Human0.81993764
149RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81733520
150TBX3_20139965_ChIP-Seq_MESCs_Mouse0.81513712
151* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80662747
152CDX2_22108803_ChIP-Seq_LS180_Human0.80234294
153GATA3_26560356_Chip-Seq_TH2_Human0.80146856
154FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.80097986
155UBF1/2_26484160_Chip-Seq_HMECs_Human0.80048287
156TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79275559
157POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78956472
158SPI1_23547873_ChIP-Seq_NB4_Human0.78115154

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.10278111
2MP0003300_gastrointestinal_ulcer2.99284076
3MP0004272_abnormal_basement_membrane2.97606820
4MP0002877_abnormal_melanocyte_morpholog2.75156170
5MP0010094_abnormal_chromosome_stability2.74782300
6MP0008438_abnormal_cutaneous_collagen2.69821989
7MP0010352_gastrointestinal_tract_polyps2.63380830
8MP0004957_abnormal_blastocyst_morpholog2.52943291
9MP0003705_abnormal_hypodermis_morpholog2.51776214
10MP0005076_abnormal_cell_differentiation2.48588404
11MP0010307_abnormal_tumor_latency2.37873634
12MP0009697_abnormal_copulation2.09385427
13MP0005275_abnormal_skin_tensile2.06953351
14MP0003183_abnormal_peptide_metabolism2.04725534
15MP0005623_abnormal_meninges_morphology1.89678387
16MP0008932_abnormal_embryonic_tissue1.87904131
17MP0003950_abnormal_plasma_membrane1.77609356
18MP0002166_altered_tumor_susceptibility1.76859615
19MP0004264_abnormal_extraembryonic_tissu1.74746234
20MP0001661_extended_life_span1.66971649
21MP0003172_abnormal_lysosome_physiology1.66184185
22MP0010234_abnormal_vibrissa_follicle1.63577021
23MP0003566_abnormal_cell_adhesion1.63418597
24MP0001730_embryonic_growth_arrest1.63219302
25MP0003252_abnormal_bile_duct1.61943351
26MP0001835_abnormal_antigen_presentation1.61368683
27MP0004233_abnormal_muscle_weight1.57649927
28MP0003984_embryonic_growth_retardation1.56452138
29MP0004947_skin_inflammation1.55750979
30MP0000537_abnormal_urethra_morphology1.55499516
31MP0006054_spinal_hemorrhage1.53900958
32MP0002084_abnormal_developmental_patter1.52682333
33MP0002088_abnormal_embryonic_growth/wei1.50474905
34MP0005220_abnormal_exocrine_pancreas1.49169792
35MP0002006_tumorigenesis1.48023480
36MP0002697_abnormal_eye_size1.47908110
37MP0008058_abnormal_DNA_repair1.45295553
38MP0003937_abnormal_limbs/digits/tail_de1.41116517
39MP0003890_abnormal_embryonic-extraembry1.37656066
40MP0000685_abnormal_immune_system1.35864547
41MP0002693_abnormal_pancreas_physiology1.35556110
42MP0010368_abnormal_lymphatic_system1.35046382
43MP0003436_decreased_susceptibility_to1.34979442
44MP0003045_fibrosis1.34435313
45MP0001697_abnormal_embryo_size1.33067616
46MP0000428_abnormal_craniofacial_morphol1.31268860
47MP0005365_abnormal_bile_salt1.29405631
48MP0001299_abnormal_eye_distance/1.28363167
49MP0002085_abnormal_embryonic_tissue1.27169969
50MP0003091_abnormal_cell_migration1.26258169
51MP0005023_abnormal_wound_healing1.23405229
52MP0003385_abnormal_body_wall1.23199062
53MP0004808_abnormal_hematopoietic_stem1.23104360
54MP0002139_abnormal_hepatobiliary_system1.19312440
55MP0005387_immune_system_phenotype1.18899606
56MP0001790_abnormal_immune_system1.18899606
57MP0009053_abnormal_anal_canal1.17906881
58MP0002138_abnormal_hepatobiliary_system1.16685800
59MP0002080_prenatal_lethality1.14609113
60MP0005058_abnormal_lysosome_morphology1.11878426
61MP0001944_abnormal_pancreas_morphology1.11581564
62MP0000371_diluted_coat_color1.10994664
63MP0005501_abnormal_skin_physiology1.10777842
64MP0002396_abnormal_hematopoietic_system1.09827147
65MP0002060_abnormal_skin_morphology1.09785351
66MP0005503_abnormal_tendon_morphology1.08444553
67MP0002928_abnormal_bile_duct1.06483005
68MP0001666_abnormal_nutrient_absorption1.06338242
69MP0000579_abnormal_nail_morphology1.06077379
70MP0001800_abnormal_humoral_immune1.05456869
71MP0000762_abnormal_tongue_morphology1.05143624
72MP0009672_abnormal_birth_weight1.04729483
73MP0008057_abnormal_DNA_replication1.04372434
74MP0003195_calcinosis1.02569662
75MP0002896_abnormal_bone_mineralization1.02113355
76MP0002796_impaired_skin_barrier1.01769599
77MP0002092_abnormal_eye_morphology1.01721048
78MP0000432_abnormal_head_morphology1.01536464
79MP0001849_ear_inflammation1.01109578
80MP0002086_abnormal_extraembryonic_tissu1.00650598
81MP0001243_abnormal_dermal_layer0.99464498
82MP0003763_abnormal_thymus_physiology0.98059780
83MP0001915_intracranial_hemorrhage0.97382760
84MP0003935_abnormal_craniofacial_develop0.97182083
85MP0001879_abnormal_lymphatic_vessel0.96763790
86MP0005187_abnormal_penis_morphology0.96011318
87MP0004185_abnormal_adipocyte_glucose0.95800388
88MP0002254_reproductive_system_inflammat0.95760409
89MP0002452_abnormal_antigen_presenting0.95629555
90MP0005310_abnormal_salivary_gland0.94516089
91MP0010155_abnormal_intestine_physiology0.93312313
92MP0000427_abnormal_hair_cycle0.92384330
93MP0003693_abnormal_embryo_hatching0.92060013
94MP0003868_abnormal_feces_composition0.91709946
95MP0003941_abnormal_skin_development0.91624993
96MP0001845_abnormal_inflammatory_respons0.91441409
97MP0009703_decreased_birth_body0.90656951
98MP0005409_darkened_coat_color0.90092089
99MP0005000_abnormal_immune_tolerance0.89474038
100MP0001216_abnormal_epidermal_layer0.88686692
101MP0005257_abnormal_intraocular_pressure0.88628573
102MP0000733_abnormal_muscle_development0.87915220
103MP0001286_abnormal_eye_development0.87799340
104MP0002998_abnormal_bone_remodeling0.87400555
105MP0000767_abnormal_smooth_muscle0.86699163
106MP0002723_abnormal_immune_serum0.86690293
107MP0002419_abnormal_innate_immunity0.86181314
108MP0001533_abnormal_skeleton_physiology0.85613683
109MP0000627_abnormal_mammary_gland0.85411001
110MP0006082_CNS_inflammation0.85391774
111MP0005384_cellular_phenotype0.85203790
112MP0003795_abnormal_bone_structure0.84872228
113MP0001958_emphysema0.84867830
114MP0002168_other_aberrant_phenotype0.84352562
115MP0000003_abnormal_adipose_tissue0.84287751
116MP0001191_abnormal_skin_condition0.84197330
117MP0003221_abnormal_cardiomyocyte_apopto0.83948009
118MP0005408_hypopigmentation0.83865578
119MP0000609_abnormal_liver_physiology0.83722300
120MP0003111_abnormal_nucleus_morphology0.83520267
121MP0009384_cardiac_valve_regurgitation0.83231765
122MP0001293_anophthalmia0.82882195
123MP0005621_abnormal_cell_physiology0.82545897
124MP0003448_altered_tumor_morphology0.82381299
125MP0003755_abnormal_palate_morphology0.82377711
126MP0003077_abnormal_cell_cycle0.81921875
127MP0002925_abnormal_cardiovascular_devel0.81110019
128MP0008007_abnormal_cellular_replicative0.80737932
129MP0003718_maternal_effect0.80571679
130MP0003303_peritoneal_inflammation0.79455788
131MP0000377_abnormal_hair_follicle0.78609739
132MP0002398_abnormal_bone_marrow0.78174227
133MP0003279_aneurysm0.77574432
134MP0002111_abnormal_tail_morphology0.77567691
135MP0000858_altered_metastatic_potential0.77340234
136MP0002233_abnormal_nose_morphology0.77056356
137MP0010678_abnormal_skin_adnexa0.76772513
138MP0005671_abnormal_response_to0.76600999
139MP0003453_abnormal_keratinocyte_physiol0.76382798
140MP0000598_abnormal_liver_morphology0.76328571
141MP0003315_abnormal_perineum_morphology0.75430882
142MP0002933_joint_inflammation0.75268403
143MP0003786_premature_aging0.75180894
144MP0010030_abnormal_orbit_morphology0.75159735
145MP0002405_respiratory_system_inflammati0.75056813
146MP0004197_abnormal_fetal_growth/weight/0.75051974
147MP0001819_abnormal_immune_cell0.74991069
148MP0005464_abnormal_platelet_physiology0.74837877
149MP0005085_abnormal_gallbladder_physiolo0.74747752
150MP0001672_abnormal_embryogenesis/_devel0.74363713
151MP0005380_embryogenesis_phenotype0.74363713
152MP0002009_preneoplasia0.74295336
153MP0003115_abnormal_respiratory_system0.74261034
154MP0000350_abnormal_cell_proliferation0.74024736
155MP0005197_abnormal_uvea_morphology0.74002922
156MP0002420_abnormal_adaptive_immunity0.73696017

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.31701015
2Premature rupture of membranes (HP:0001788)3.91757353
3Chromsome breakage (HP:0040012)3.49825157
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.41140478
5Abnormality of the nasal septum (HP:0000419)3.32808596
6Atrophic scars (HP:0001075)2.97237269
7Macroorchidism (HP:0000053)2.96112802
8Subacute progressive viral hepatitis (HP:0006572)2.78579711
9Cervical subluxation (HP:0003308)2.76699714
10Hyperglycemia (HP:0003074)2.67447582
11Absent frontal sinuses (HP:0002688)2.61680872
12Global brain atrophy (HP:0002283)2.61530354
13Selective tooth agenesis (HP:0001592)2.61523436
14Aortic dissection (HP:0002647)2.58977550
15Spinal cord lesions (HP:0100561)2.55148913
16Syringomyelia (HP:0003396)2.55148913
17Long eyelashes (HP:0000527)2.54756937
18Arterial tortuosity (HP:0005116)2.53177973
19Volvulus (HP:0002580)2.52519199
20Osteolytic defects of the hand bones (HP:0009699)2.51871535
21Osteolytic defects of the phalanges of the hand (HP:0009771)2.51871535
22Nephroblastoma (Wilms tumor) (HP:0002667)2.51595603
23Overgrowth (HP:0001548)2.49024538
24Vascular tortuosity (HP:0004948)2.45846407
25Periodontitis (HP:0000704)2.45139277
26Embryonal renal neoplasm (HP:0011794)2.42549581
27Eczematoid dermatitis (HP:0000976)2.42493522
28Myocardial infarction (HP:0001658)2.40671426
29Relative macrocephaly (HP:0004482)2.36270978
30Entropion (HP:0000621)2.35542537
31Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.33587307
32Ankyloglossia (HP:0010296)2.29723620
33Abnormality of chromosome stability (HP:0003220)2.27537148
34Autoimmune thrombocytopenia (HP:0001973)2.24325118
35Hematochezia (HP:0002573)2.23117956
36Increased nuchal translucency (HP:0010880)2.21549445
37Abnormality of the intrinsic pathway (HP:0010989)2.20875296
38Asymmetry of the thorax (HP:0001555)2.17813408
39Hypoglycemic seizures (HP:0002173)2.14752002
40Soft skin (HP:0000977)2.13593841
41Deviation of the thumb (HP:0009603)2.13526127
42Hypoplastic labia majora (HP:0000059)2.13359389
43Broad face (HP:0000283)2.13013487
44Hyperinsulinemic hypoglycemia (HP:0000825)2.12522130
45Poikiloderma (HP:0001029)2.12001996
46Abnormality of the frontal sinuses (HP:0002687)2.09047874
47Lip pit (HP:0100267)2.08826370
48Truncal obesity (HP:0001956)2.08745854
49Narrow palate (HP:0000189)2.07456230
50Impulsivity (HP:0100710)2.06362658
51Abnormality of the common coagulation pathway (HP:0010990)2.04432927
52Ulnar bowing (HP:0003031)2.03499173
53Complement deficiency (HP:0004431)2.02812633
54Abnormality of oral frenula (HP:0000190)2.02331709
55Natal tooth (HP:0000695)2.02265231
56Hypoplastic ischia (HP:0003175)2.01285483
57T lymphocytopenia (HP:0005403)2.01236169
58Insulin-resistant diabetes mellitus (HP:0000831)2.01235691
59Aortic aneurysm (HP:0004942)2.01192598
60Persistence of primary teeth (HP:0006335)2.00971657
61Abnormal foot bone ossification (HP:0010675)2.00523228
62Micronodular cirrhosis (HP:0001413)1.98610792
63Overlapping toe (HP:0001845)1.98227704
64Cerebral aneurysm (HP:0004944)1.97813448
65Glomerulonephritis (HP:0000099)1.97772738
66Sandal gap (HP:0001852)1.97603904
67Recurrent bacterial skin infections (HP:0005406)1.97396048
68Abnormality of T cell number (HP:0011839)1.97063081
69Bladder diverticulum (HP:0000015)1.96577837
70Vertebral arch anomaly (HP:0008438)1.96278013
71Recurrent gram-negative bacterial infections (HP:0005420)1.95892405
72Missing ribs (HP:0000921)1.95738834
73Fragile skin (HP:0001030)1.95022625
74Capillary hemangiomas (HP:0005306)1.94861421
75Wormian bones (HP:0002645)1.94516898
76Metaphyseal cupping (HP:0003021)1.93543799
77Malignant gastrointestinal tract tumors (HP:0006749)1.92206795
78Gastrointestinal carcinoma (HP:0002672)1.92206795
79Recurrent viral infections (HP:0004429)1.90447378
80Rhabdomyosarcoma (HP:0002859)1.89525868
81Spastic diplegia (HP:0001264)1.89485097
82Proximal placement of thumb (HP:0009623)1.88113167
83Skull defect (HP:0001362)1.86774676
84Abnormality of the labia majora (HP:0012881)1.86652056
85Acute myeloid leukemia (HP:0004808)1.85387468
86Right ventricular cardiomyopathy (HP:0011663)1.85014595
87Abnormality of the ischium (HP:0003174)1.84901982
88Low anterior hairline (HP:0000294)1.84885860
89Cortical dysplasia (HP:0002539)1.83582152
90Urethral obstruction (HP:0000796)1.82636993
91Deep philtrum (HP:0002002)1.81198685
92Severe short stature (HP:0003510)1.81103325
93Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.80973319
94Abnormality of dentin (HP:0010299)1.78892001
95Advanced eruption of teeth (HP:0006288)1.78813622
96Leiomyosarcoma (HP:0100243)1.78730084
97Uterine leiomyosarcoma (HP:0002891)1.78730084
98Termporal pattern (HP:0011008)1.78561168
99Insidious onset (HP:0003587)1.78561168
100Long foot (HP:0001833)1.78339088
101Thoracolumbar scoliosis (HP:0002944)1.78063577
102Orthostatic hypotension (HP:0001278)1.77572568
103Dislocated radial head (HP:0003083)1.77283307
104Short humerus (HP:0005792)1.76569658
105Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75958877
106Neoplasm of the tracheobronchial system (HP:0100552)1.74872983
107Bowel diverticulosis (HP:0005222)1.74490861
108Broad thumb (HP:0011304)1.74324971
109Arterial thrombosis (HP:0004420)1.74217065
110Biliary tract neoplasm (HP:0100574)1.74068677
111Abnormality of incisor morphology (HP:0011063)1.73658807
112Abnormality of nail color (HP:0100643)1.72799487
113Ankle contracture (HP:0006466)1.72330833
114Mitral valve prolapse (HP:0001634)1.72146743
115Aneurysm (HP:0002617)1.71893972
116Gingivitis (HP:0000230)1.70966792
117Recurrent abscess formation (HP:0002722)1.70884634
118Transitional cell carcinoma of the bladder (HP:0006740)1.69772443
119Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69490590
120Shallow orbits (HP:0000586)1.69106783
121Abnormality of complement system (HP:0005339)1.68984340
122Recurrent fungal infections (HP:0002841)1.68514205
123Hypopigmentation of the fundus (HP:0007894)1.68355553
124Hypoglycemic coma (HP:0001325)1.67996139
125Dysmetric saccades (HP:0000641)1.67937512
126Mesomelia (HP:0003027)1.67865645
127Prominent nose (HP:0000448)1.67370122
128Bladder neoplasm (HP:0009725)1.66727350
129Bladder carcinoma (HP:0002862)1.66727350
130Thick nail (HP:0001805)1.66525025
131Chronic diarrhea (HP:0002028)1.66225317
132Symptomatic seizures (HP:0011145)1.66114433
133Medulloblastoma (HP:0002885)1.65827273
134Progressive external ophthalmoplegia (HP:0000590)1.64770302
135Heterotopia (HP:0002282)1.64485343
136Hypochromic microcytic anemia (HP:0004840)1.64349753
137Dilatation of the ascending aorta (HP:0005111)1.63427024
138Increased CSF protein (HP:0002922)1.61648660
139Abnormality of the radial head (HP:0003995)1.61170107
140Renovascular hypertension (HP:0100817)1.60866119
141Abnormality of the distal phalanx of the thumb (HP:0009617)1.60532472
142Papillary thyroid carcinoma (HP:0002895)1.59777011
143Increased mean platelet volume (HP:0011877)1.58491087
144Abnormality of the vasculature of the conjunctiva (HP:0008054)1.58163054
145Cutaneous melanoma (HP:0012056)1.57897681
146Squamous cell carcinoma (HP:0002860)1.57697682
147Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.57390233
148Abnormality of the preputium (HP:0100587)1.56804576
149Abnormal biliary tract morphology (HP:0012440)1.56708122
150Joint laxity (HP:0001388)1.55899156
151IgA deficiency (HP:0002720)1.55861363
152Alveolar cell carcinoma (HP:0006519)1.55686572
153Protrusio acetabuli (HP:0003179)1.55586009
154Abnormality of the acetabulum (HP:0003170)1.55497622
155Follicular hyperkeratosis (HP:0007502)1.55338582
156Small intestinal stenosis (HP:0012848)1.55288640
157Duodenal stenosis (HP:0100867)1.55288640
158Milia (HP:0001056)1.54754115
159Acanthocytosis (HP:0001927)1.54536441
160Aplasia/Hypoplasia of the uvula (HP:0010293)1.54156625
161Hepatoblastoma (HP:0002884)1.54128256
162Retinal atrophy (HP:0001105)1.53851470
163Aplasia/hypoplasia of the humerus (HP:0006507)1.53777141
164Mucopolysacchariduria (HP:0008155)1.53698723
165Urinary glycosaminoglycan excretion (HP:0003541)1.53698723
166Nephritis (HP:0000123)1.52767856
167Abnormality of the pancreatic islet cells (HP:0006476)1.52371319
168Abnormality of endocrine pancreas physiology (HP:0012093)1.52371319
169Hepatocellular carcinoma (HP:0001402)1.51724323
170Increased density of long bones (HP:0006392)1.51529778
171Esophageal varix (HP:0002040)1.51274239
172Pulmonic stenosis (HP:0001642)1.51256163
173Flat acetabular roof (HP:0003180)1.51147710
174Thyroid carcinoma (HP:0002890)1.51087458
175Renal duplication (HP:0000075)1.50842044
176Depressed nasal tip (HP:0000437)1.50507472
177Spondylolisthesis (HP:0003302)1.50408675
178Coarse hair (HP:0002208)1.49379099
179Intrahepatic cholestasis (HP:0001406)1.48959957
180Conjunctival telangiectasia (HP:0000524)1.48485452

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.34608104
2LATS12.69077483
3FRK2.61454005
4CDK122.50580838
5SRPK12.21828906
6FGFR32.21697229
7JAK32.20504873
8NEK12.19858340
9FLT32.09418867
10ZAK2.09412206
11ACVR1B2.03644500
12BUB12.02967161
13RIPK11.96759029
14PDGFRA1.94702817
15PBK1.94144727
16PKN21.89469846
17MAP3K141.89171651
18TSSK61.84022952
19FGFR41.83673510
20JAK11.80305268
21CAMK1D1.70243594
22TYK21.68951715
23EPHA31.66733243
24STK31.63960420
25SCYL21.62380773
26MST1R1.62018188
27CHUK1.60979414
28INSRR1.60487569
29NEK21.57658319
30PASK1.55982227
31PTK61.55900615
32MKNK21.45899984
33STK38L1.42988924
34TTN1.42164595
35MKNK11.41983874
36NUAK11.41326507
37TAF11.39955687
38PDGFRB1.39644227
39LATS21.35495171
40IKBKE1.35308126
41CHEK21.31657818
42PLK41.29459039
43NEK91.28426376
44SIK11.27253153
45ICK1.26405279
46EIF2AK11.24350187
47PLK31.23275337
48RPS6KA41.23008900
49TBK11.18854599
50MTOR1.16029937
51STK241.14301638
52TXK1.14273384
53CDC71.14075037
54PLK11.12801680
55CDK61.12650833
56CAMK1G1.11684157
57ERBB31.11264974
58SMG11.09920614
59STK101.09770097
60MAP3K31.09657116
61ERN11.09538318
62BRD41.07653981
63MAP4K11.06807219
64BCR1.06466464
65MAP3K101.06049391
66TRPM71.04503019
67CDK70.99803324
68HIPK20.98165426
69PAK40.94889937
70IKBKB0.92091384
71KIT0.91655888
72NTRK10.91301615
73EPHA20.91111787
74WEE10.89956653
75FER0.89036850
76BRSK20.86630901
77JAK20.84848978
78ATR0.83939355
79EEF2K0.82219053
80ZAP700.81380325
81PNCK0.80613632
82PTK20.79612139
83TEC0.77871243
84AKT30.77418726
85STK40.77252750
86ERBB40.75864786
87EIF2AK20.75211771
88IRAK30.75209437
89SGK30.73934686
90ITK0.73824229
91MAP3K20.71370922
92TRIB30.69939897
93CDK40.68881827
94ATM0.68540452
95TGFBR20.67151921
96MELK0.64894304
97CSF1R0.64011203
98PIK3CG0.63816755
99MST40.63567837
100PIK3CA0.63238643
101SGK20.62896214
102PIM10.62587191
103CSK0.62117551
104MAP3K130.60680655
105STK390.60210561
106MET0.60077922
107AURKB0.59938363
108TGFBR10.59592831
109EGFR0.59425277
110NLK0.58827109
111WNK10.58558969
112CHEK10.57612950
113EIF2AK30.57046897
114FGFR10.56446877
115DDR20.53914579
116CAMK40.53501444
117IRAK40.53133709
118TTK0.51863828
119DYRK30.51744783
120BRAF0.51374149
121RPS6KB20.51225672
122ERBB20.51056420
123CDK10.50966333
124GSK3A0.49819374
125PAK20.48541611
126CLK10.48528904
127EPHB10.47397477
128CDK80.46311838
129MAP2K30.45746563
130CDK20.45334825
131IGF1R0.45318601
132MAP3K80.44730935
133LCK0.44115860
134TRIM280.43949025
135AKT10.43183166
136RPS6KB10.42474558
137CDK90.41803183
138HCK0.41315862
139NEK60.40018495
140TIE10.39635511
141PRKDC0.39405224
142CSNK1A1L0.39219300
143PLK20.36079512
144YES10.34877469
145BRSK10.34052691
146AKT20.33029060
147AURKA0.32782484
148ALK0.32562040
149CSNK1E0.31605447
150MYLK0.30850659

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.49226144
2Non-homologous end-joining_Homo sapiens_hsa034503.26404704
3DNA replication_Homo sapiens_hsa030302.48367395
4Mismatch repair_Homo sapiens_hsa034302.25834014
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.20418009
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.07586266
7Nucleotide excision repair_Homo sapiens_hsa034202.00928573
8One carbon pool by folate_Homo sapiens_hsa006701.97977618
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.89101986
10Selenocompound metabolism_Homo sapiens_hsa004501.82816278
11Staphylococcus aureus infection_Homo sapiens_hsa051501.80530000
12Thyroid cancer_Homo sapiens_hsa052161.74559105
13Fanconi anemia pathway_Homo sapiens_hsa034601.68937335
14Legionellosis_Homo sapiens_hsa051341.59654451
15Antigen processing and presentation_Homo sapiens_hsa046121.52747681
16mRNA surveillance pathway_Homo sapiens_hsa030151.50817499
17Adherens junction_Homo sapiens_hsa045201.49426406
18Herpes simplex infection_Homo sapiens_hsa051681.46251286
19Measles_Homo sapiens_hsa051621.45763140
20Influenza A_Homo sapiens_hsa051641.43323126
21TNF signaling pathway_Homo sapiens_hsa046681.42474517
22Leishmaniasis_Homo sapiens_hsa051401.40640741
23Hippo signaling pathway_Homo sapiens_hsa043901.38926164
24Homologous recombination_Homo sapiens_hsa034401.38269655
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36938638
26Viral carcinogenesis_Homo sapiens_hsa052031.36768044
27Small cell lung cancer_Homo sapiens_hsa052221.35473847
28Systemic lupus erythematosus_Homo sapiens_hsa053221.35153484
29Lysine degradation_Homo sapiens_hsa003101.34280504
30Spliceosome_Homo sapiens_hsa030401.31398598
31Osteoclast differentiation_Homo sapiens_hsa043801.27136201
32Toxoplasmosis_Homo sapiens_hsa051451.25108594
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25038881
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24962076
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24493508
36TGF-beta signaling pathway_Homo sapiens_hsa043501.23826176
37MicroRNAs in cancer_Homo sapiens_hsa052061.23657801
38Hepatitis B_Homo sapiens_hsa051611.23561152
39Prostate cancer_Homo sapiens_hsa052151.22295958
40Type II diabetes mellitus_Homo sapiens_hsa049301.16846171
41Alcoholism_Homo sapiens_hsa050341.16746953
42Apoptosis_Homo sapiens_hsa042101.15987437
43Colorectal cancer_Homo sapiens_hsa052101.15877301
44Complement and coagulation cascades_Homo sapiens_hsa046101.15443479
45Caffeine metabolism_Homo sapiens_hsa002321.14780972
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12421243
47Chronic myeloid leukemia_Homo sapiens_hsa052201.12082868
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10897872
49p53 signaling pathway_Homo sapiens_hsa041151.10355361
50Basal transcription factors_Homo sapiens_hsa030221.10210586
51Insulin resistance_Homo sapiens_hsa049311.09997660
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.09134026
53Type I diabetes mellitus_Homo sapiens_hsa049401.08920442
54Vitamin B6 metabolism_Homo sapiens_hsa007501.06958533
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.04821565
56Melanoma_Homo sapiens_hsa052181.02733105
57Protein export_Homo sapiens_hsa030601.02583845
58Malaria_Homo sapiens_hsa051441.02499589
59Cyanoamino acid metabolism_Homo sapiens_hsa004601.01857246
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01085842
61Intestinal immune network for IgA production_Homo sapiens_hsa046721.00270912
62Steroid biosynthesis_Homo sapiens_hsa001000.99476549
63ECM-receptor interaction_Homo sapiens_hsa045120.98082036
64Pancreatic cancer_Homo sapiens_hsa052120.97203320
65Tight junction_Homo sapiens_hsa045300.94899209
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94691793
67Lysosome_Homo sapiens_hsa041420.93910482
68mTOR signaling pathway_Homo sapiens_hsa041500.93543799
69RNA degradation_Homo sapiens_hsa030180.93095334
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93022877
71Proteoglycans in cancer_Homo sapiens_hsa052050.92341777
72Sulfur metabolism_Homo sapiens_hsa009200.91454180
73Biosynthesis of amino acids_Homo sapiens_hsa012300.91374803
74Non-small cell lung cancer_Homo sapiens_hsa052230.90924343
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89975382
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89828677
77ABC transporters_Homo sapiens_hsa020100.89122017
78N-Glycan biosynthesis_Homo sapiens_hsa005100.89026624
79Tuberculosis_Homo sapiens_hsa051520.88995055
80Glioma_Homo sapiens_hsa052140.88677666
81Focal adhesion_Homo sapiens_hsa045100.88029049
82B cell receptor signaling pathway_Homo sapiens_hsa046620.86956218
83Pathways in cancer_Homo sapiens_hsa052000.86413603
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86027480
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85768741
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85284725
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.85151196
88HTLV-I infection_Homo sapiens_hsa051660.83865280
89Prolactin signaling pathway_Homo sapiens_hsa049170.83298351
90Hematopoietic cell lineage_Homo sapiens_hsa046400.82822627
91Oocyte meiosis_Homo sapiens_hsa041140.81712856
92Amoebiasis_Homo sapiens_hsa051460.81571048
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80975432
94Graft-versus-host disease_Homo sapiens_hsa053320.80072269
95Basal cell carcinoma_Homo sapiens_hsa052170.79602221
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.79480272
97FoxO signaling pathway_Homo sapiens_hsa040680.78971134
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78964449
99Base excision repair_Homo sapiens_hsa034100.78778640
100Renal cell carcinoma_Homo sapiens_hsa052110.76800785
101Hepatitis C_Homo sapiens_hsa051600.76637299
102Inositol phosphate metabolism_Homo sapiens_hsa005620.75558547
103Protein digestion and absorption_Homo sapiens_hsa049740.73357758
104Acute myeloid leukemia_Homo sapiens_hsa052210.73300907
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71285624
106T cell receptor signaling pathway_Homo sapiens_hsa046600.71152599
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71145540
108Allograft rejection_Homo sapiens_hsa053300.71144542
109Fatty acid biosynthesis_Homo sapiens_hsa000610.70890726
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70247604
111Folate biosynthesis_Homo sapiens_hsa007900.68766582
112Pertussis_Homo sapiens_hsa051330.67968783
113Cell cycle_Homo sapiens_hsa041100.67814578
114Viral myocarditis_Homo sapiens_hsa054160.65864993
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65498753
116Wnt signaling pathway_Homo sapiens_hsa043100.63768077
117Hedgehog signaling pathway_Homo sapiens_hsa043400.63075022
118Notch signaling pathway_Homo sapiens_hsa043300.62581731
119Renin-angiotensin system_Homo sapiens_hsa046140.59281289
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59246522
121ErbB signaling pathway_Homo sapiens_hsa040120.59052560
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58994584
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55583141
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54599282
125Pyrimidine metabolism_Homo sapiens_hsa002400.54173447
126Endometrial cancer_Homo sapiens_hsa052130.53171628
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52537862
128Epstein-Barr virus infection_Homo sapiens_hsa051690.52342869
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51709903
130Fat digestion and absorption_Homo sapiens_hsa049750.51530482
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.50508918
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50193079
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49921104
134RNA transport_Homo sapiens_hsa030130.48656735
135Primary immunodeficiency_Homo sapiens_hsa053400.48539077
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48187814
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47725845
138Platelet activation_Homo sapiens_hsa046110.47678530
139Starch and sucrose metabolism_Homo sapiens_hsa005000.47285923
140Pentose phosphate pathway_Homo sapiens_hsa000300.46859348
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45297627
142Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44360946
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44092081
144Carbon metabolism_Homo sapiens_hsa012000.43490651
145Pyruvate metabolism_Homo sapiens_hsa006200.43190880
146Insulin signaling pathway_Homo sapiens_hsa049100.42952339
147Bladder cancer_Homo sapiens_hsa052190.42828476
148AMPK signaling pathway_Homo sapiens_hsa041520.42765963
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42260837
150Sphingolipid metabolism_Homo sapiens_hsa006000.40117067
151HIF-1 signaling pathway_Homo sapiens_hsa040660.39568568
152Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36221764
153Shigellosis_Homo sapiens_hsa051310.34992645

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