ASCL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal stem cell maintenance (GO:0097150)5.80584998
2protein localization to microtubule (GO:0035372)5.38824581
3pyrimidine nucleobase catabolic process (GO:0006208)5.14642838
4auditory receptor cell differentiation (GO:0042491)4.87532641
5* forebrain neuron differentiation (GO:0021879)4.70655835
6postsynaptic membrane organization (GO:0001941)4.69833276
7negative regulation of oligodendrocyte differentiation (GO:0048715)4.67270279
8glial cell proliferation (GO:0014009)4.33651863
9* positive regulation of Notch signaling pathway (GO:0045747)4.26162777
10gamma-aminobutyric acid transport (GO:0015812)4.25463618
11positive regulation of oligodendrocyte differentiation (GO:0048714)4.24960921
12presynaptic membrane assembly (GO:0097105)4.23038214
13cardiac right ventricle morphogenesis (GO:0003215)4.20851537
14* neuron fate specification (GO:0048665)4.17856265
15spinal cord development (GO:0021510)4.16115299
16regulation of cardioblast proliferation (GO:0003264)4.15353214
17regulation of secondary heart field cardioblast proliferation (GO:0003266)4.15353214
18endocardial cushion morphogenesis (GO:0003203)4.01068307
19negative regulation of epidermal cell differentiation (GO:0045605)3.99092961
20regulation of transcription involved in cell fate commitment (GO:0060850)3.96891296
21positive regulation of gastrulation (GO:2000543)3.93855989
22dendritic spine morphogenesis (GO:0060997)3.87437600
23nucleobase catabolic process (GO:0046113)3.87175324
24regulation of glycogen (starch) synthase activity (GO:2000465)3.81103426
25* spinal cord association neuron differentiation (GO:0021527)3.79398536
26nonmotile primary cilium assembly (GO:0035058)3.77526955
27heart valve formation (GO:0003188)3.72235481
28limb bud formation (GO:0060174)3.67324010
29lens morphogenesis in camera-type eye (GO:0002089)3.66388504
30regulation of NFAT protein import into nucleus (GO:0051532)3.62909745
31transmission of nerve impulse (GO:0019226)3.61867287
32left/right axis specification (GO:0070986)3.58618126
33presynaptic membrane organization (GO:0097090)3.58075785
34axonal fasciculation (GO:0007413)3.54395667
35membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.52739920
36sequestering of actin monomers (GO:0042989)3.52405041
37regulation of growth hormone secretion (GO:0060123)3.48659173
38nephron tubule development (GO:0072080)3.48261229
39vocalization behavior (GO:0071625)3.47766703
40retinal ganglion cell axon guidance (GO:0031290)3.47124119
41coronary vasculature morphogenesis (GO:0060977)3.43992801
42negative regulation of gliogenesis (GO:0014014)3.42787278
43regulation of somitogenesis (GO:0014807)3.41320067
44cerebral cortex radially oriented cell migration (GO:0021799)3.36089858
45epithelial cell differentiation involved in prostate gland development (GO:0060742)3.35700688
46renal tubule development (GO:0061326)3.34657682
47auditory behavior (GO:0031223)3.32429235
48neural tube formation (GO:0001841)3.31189562
49negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.30638392
50neuron fate determination (GO:0048664)3.27993501
51suckling behavior (GO:0001967)3.27972442
52growth hormone secretion (GO:0030252)3.26766708
53synapse assembly (GO:0007416)3.26451364
54mesenchyme morphogenesis (GO:0072132)3.25541955
55appendage development (GO:0048736)3.24663934
56limb development (GO:0060173)3.24663934
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.23422552
58eye photoreceptor cell differentiation (GO:0001754)3.23004021
59photoreceptor cell differentiation (GO:0046530)3.23004021
60establishment of mitochondrion localization (GO:0051654)3.22619036
61cranial nerve morphogenesis (GO:0021602)3.22586058
62* cell differentiation in spinal cord (GO:0021515)3.22478528
63hippocampus development (GO:0021766)3.22345356
64negative regulation of interleukin-10 production (GO:0032693)3.20831819
65protein localization to microtubule cytoskeleton (GO:0072698)3.19984359
66* cerebral cortex neuron differentiation (GO:0021895)3.19909888
67astrocyte differentiation (GO:0048708)3.19172910
68negative regulation of cardiac muscle hypertrophy (GO:0010614)3.18555635
69positive regulation of growth hormone secretion (GO:0060124)3.18501123
70synaptic vesicle exocytosis (GO:0016079)3.18203089
71regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.17412622
72regulation of heart rate by cardiac conduction (GO:0086091)3.16008223
73synaptic vesicle endocytosis (GO:0048488)3.15948189
74segment specification (GO:0007379)3.15520060
75neuron projection extension involved in neuron projection guidance (GO:1902284)3.14581137
76axon extension involved in axon guidance (GO:0048846)3.14581137
77membrane repolarization during action potential (GO:0086011)3.13465859
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.13079590
79negative regulation of Notch signaling pathway (GO:0045746)3.12758413
80regulation of sarcomere organization (GO:0060297)3.11611513
81cardiac ventricle formation (GO:0003211)3.11590033
82negative regulation of glycogen biosynthetic process (GO:0045719)3.10913663
83epithelial cell fate commitment (GO:0072148)3.10801211
84cerebral cortex cell migration (GO:0021795)3.10692700
85Notch signaling involved in heart development (GO:0061314)3.10356004
86myoblast migration (GO:0051451)3.09919657
87positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.07875581
88* regulation of Notch signaling pathway (GO:0008593)3.06218562
89negative regulation of transcription regulatory region DNA binding (GO:2000678)3.04122818
90microtubule depolymerization (GO:0007019)3.03823494
91negative regulation of epidermis development (GO:0045683)3.03797167
92metanephric mesenchyme development (GO:0072075)3.01905197
93substrate-independent telencephalic tangential migration (GO:0021826)3.01278086
94substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.01278086
95ovulation cycle (GO:0042698)3.01133057
96proximal/distal pattern formation (GO:0009954)2.99086761
97regulation of glial cell differentiation (GO:0045685)2.98449513
98establishment of nucleus localization (GO:0040023)2.97881016
99epithelial tube branching involved in lung morphogenesis (GO:0060441)2.97573862
100hair cell differentiation (GO:0035315)2.94718724
101embryonic foregut morphogenesis (GO:0048617)2.92778085
102nephron tubule formation (GO:0072079)2.91957367
103spinal cord motor neuron differentiation (GO:0021522)2.91576072
104neuron recognition (GO:0008038)2.91120476
105central nervous system projection neuron axonogenesis (GO:0021952)2.90905995
106kidney mesenchyme development (GO:0072074)2.90661361
107heart valve morphogenesis (GO:0003179)2.90539951
108Notch receptor processing (GO:0007220)2.90188144
109glycosphingolipid biosynthetic process (GO:0006688)2.90087647
110DNA damage response, detection of DNA damage (GO:0042769)2.89168582
111negative regulation of muscle hypertrophy (GO:0014741)2.88512530
112response to auditory stimulus (GO:0010996)2.88459830
113regulation of skeletal muscle cell differentiation (GO:2001014)2.88442037
114protein localization to synapse (GO:0035418)2.87590427
115somite development (GO:0061053)2.87422909
116olfactory bulb development (GO:0021772)2.87173592
117regulation of respiratory system process (GO:0044065)2.86983328
118positive regulation of synapse assembly (GO:0051965)2.85749737
119behavioral response to nicotine (GO:0035095)2.84308773
120mechanosensory behavior (GO:0007638)2.84120968
121regulation of oligodendrocyte differentiation (GO:0048713)2.83906842
122layer formation in cerebral cortex (GO:0021819)2.83472943
123cerebellar granule cell differentiation (GO:0021707)2.80036018
124cochlea morphogenesis (GO:0090103)2.78716277
125* cell fate determination (GO:0001709)2.78481025
126glycerophospholipid catabolic process (GO:0046475)2.78267924
127DNA integration (GO:0015074)2.78253112
128calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.74065177
129atrial cardiac muscle cell action potential (GO:0086014)2.73950155
130ventricular cardiac muscle cell action potential (GO:0086005)2.73948509
131collecting duct development (GO:0072044)2.73031973
132negative regulation of glycogen metabolic process (GO:0070874)2.71339649
133cardiac chamber formation (GO:0003207)2.70748765
134outer ear morphogenesis (GO:0042473)2.70231271
135epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.69663866
136protein localization to cytoskeleton (GO:0044380)2.68821312
137positive regulation of circadian rhythm (GO:0042753)2.67827105
138positive regulation of mitochondrial fission (GO:0090141)2.67000252
139oligodendrocyte differentiation (GO:0048709)2.66944910
140regulation of heart morphogenesis (GO:2000826)2.66621913
141* central nervous system neuron differentiation (GO:0021953)2.66484848
142multicellular organismal aging (GO:0010259)2.65654443
143ionotropic glutamate receptor signaling pathway (GO:0035235)2.65449288
144epithelial cilium movement (GO:0003351)2.65397289
145establishment of integrated proviral latency (GO:0075713)2.65302615
146negative regulation of glial cell differentiation (GO:0045686)2.64072177
147neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.63781225
148* cell fate specification (GO:0001708)2.63557357
149neuron cell-cell adhesion (GO:0007158)2.63402830
150positive regulation of nitric-oxide synthase activity (GO:0051000)2.62943626
151cranial nerve development (GO:0021545)2.62689923
152cardiac muscle hypertrophy (GO:0003300)2.61923154
153locomotory exploration behavior (GO:0035641)2.61146638
154regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.60488248
155pituitary gland development (GO:0021983)2.60212232
156negative regulation of potassium ion transmembrane transport (GO:1901380)2.59967680
157positive regulation of embryonic development (GO:0040019)2.59912427
158regulation of protein export from nucleus (GO:0046825)2.59894513
159cell migration in hindbrain (GO:0021535)2.59825093
160nephron epithelium development (GO:0072009)2.59718318
161inner ear receptor cell differentiation (GO:0060113)2.59702482
162proline transport (GO:0015824)2.59446490
163intraciliary transport (GO:0042073)2.59238485
164* neuron fate commitment (GO:0048663)2.58242836
165regulation of synaptic vesicle exocytosis (GO:2000300)2.57218533
166regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.55342232
167atrial septum morphogenesis (GO:0060413)2.55159763
168positive regulation of actin filament depolymerization (GO:0030836)2.54645698
169cardiac conduction (GO:0061337)2.54377711
170regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.54207490
171positive regulation of mesonephros development (GO:0061213)2.54029768
172apical protein localization (GO:0045176)2.53936324
173positive regulation of neuroblast proliferation (GO:0002052)2.53184494
174midgut development (GO:0007494)2.52169383

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.60615962
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.27920302
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.21131972
4EZH2_27304074_Chip-Seq_ESCs_Mouse3.11033149
5* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78274019
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78274019
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.77153593
8* EED_16625203_ChIP-ChIP_MESCs_Mouse2.73097769
9* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71231572
10* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.54628948
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48400147
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43592598
13* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.38955863
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.34780323
15* RNF2_27304074_Chip-Seq_ESCs_Mouse2.34360998
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28896788
17* EZH2_27294783_Chip-Seq_ESCs_Mouse2.27422002
18* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.25677442
19* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24855471
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22147514
21* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.16682172
22* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11847851
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.10093156
24* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.07613607
25GBX2_23144817_ChIP-Seq_PC3_Human2.07393275
26EZH2_22144423_ChIP-Seq_EOC_Human2.04987094
27* RING1B_27294783_Chip-Seq_NPCs_Mouse2.04322794
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00868736
29RNF2_27304074_Chip-Seq_NSC_Mouse2.00775017
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.98477619
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97767949
32* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.88141339
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87721799
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87398122
35IGF1R_20145208_ChIP-Seq_DFB_Human1.87268765
36* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87081360
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.83297095
38* TP53_20018659_ChIP-ChIP_R1E_Mouse1.79405592
39* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78482805
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77296269
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75734854
42FUS_26573619_Chip-Seq_HEK293_Human1.74873640
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72684142
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.72167646
45* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.69252570
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.67629152
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67366596
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62035410
49ZNF274_21170338_ChIP-Seq_K562_Hela1.59931700
50AR_21572438_ChIP-Seq_LNCaP_Human1.55524820
51TAF15_26573619_Chip-Seq_HEK293_Human1.53940685
52* RING1B_27294783_Chip-Seq_ESCs_Mouse1.52707860
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52168813
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49756786
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49740315
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44361930
57* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.42960779
58* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42898901
59VDR_22108803_ChIP-Seq_LS180_Human1.42356538
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.39824678
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35848950
62DROSHA_22980978_ChIP-Seq_HELA_Human1.35019331
63* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33305056
64* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33305056
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33211294
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32536408
67REST_21632747_ChIP-Seq_MESCs_Mouse1.32486350
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.32398368
69* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30644033
70TCF4_18268006_ChIP-ChIP_LS174T_Human1.29973276
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29220862
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28351056
73* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25226764
74* SMAD3_21741376_ChIP-Seq_EPCs_Human1.24659289
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24435528
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21812627
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21337910
78EWS_26573619_Chip-Seq_HEK293_Human1.20745790
79TP53_18474530_ChIP-ChIP_U2OS_Human1.19491658
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19176020
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17597027
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17009226
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16605903
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15872032
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14457340
86IRF1_19129219_ChIP-ChIP_H3396_Human1.11682835
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11658408
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10951548
89P300_19829295_ChIP-Seq_ESCs_Human1.10673790
90* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10566102
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10471224
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10135464
93ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09838647
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09734306
95* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09410671
96SMAD4_21799915_ChIP-Seq_A2780_Human1.09389882
97* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09325391
98AHR_22903824_ChIP-Seq_MCF-7_Human1.09159497
99* KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08587384
100* KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08587384
101* KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08587384
102CDX2_20551321_ChIP-Seq_CACO-2_Human1.07553735
103SOX2_16153702_ChIP-ChIP_HESCs_Human1.06429738
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05139295
105AR_25329375_ChIP-Seq_VCAP_Human1.05125928
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03039216
107FOXM1_23109430_ChIP-Seq_U2OS_Human1.02788536
108SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01888744
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01831368
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00339201
111* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00258114
112RUNX2_22187159_ChIP-Seq_PCA_Human0.99767201
113REST_18959480_ChIP-ChIP_MESCs_Mouse0.99638643
114STAT3_23295773_ChIP-Seq_U87_Human0.99075142
115WDR5_24793694_ChIP-Seq_LNCAP_Human0.98876654
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.98802085
117* AR_19668381_ChIP-Seq_PC3_Human0.98308965
118RARB_27405468_Chip-Seq_BRAIN_Mouse0.97052016
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96493827
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95699281
121NANOG_18555785_Chip-Seq_ESCs_Mouse0.95664239
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94874836
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94586645
124FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92886238
125PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92704091
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91086617
127SOX2_21211035_ChIP-Seq_LN229_Gbm0.91080978
128TAL1_26923725_Chip-Seq_HPCs_Mouse0.91019750
129TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89451358
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88799315
131* RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88449962
132* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87658217
133TCF4_23295773_ChIP-Seq_U87_Human0.85935601
134CBP_20019798_ChIP-Seq_JUKART_Human0.83927580

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis5.23876938
2MP0010030_abnormal_orbit_morphology4.01040667
3MP0002822_catalepsy3.73427651
4MP0009780_abnormal_chondrocyte_physiolo3.08978375
5MP0002234_abnormal_pharynx_morphology3.02356486
6MP0005171_absent_coat_pigmentation2.99014185
7MP0003880_abnormal_central_pattern2.93667867
8MP0000537_abnormal_urethra_morphology2.61997652
9MP0003787_abnormal_imprinting2.49417775
10MP0001529_abnormal_vocalization2.45071229
11MP0001299_abnormal_eye_distance/2.37601021
12MP0000778_abnormal_nervous_system2.33611430
13MP0008995_early_reproductive_senescence2.26653713
14MP0002277_abnormal_respiratory_mucosa2.23777205
15MP0009250_abnormal_appendicular_skeleto2.22378548
16MP0002837_dystrophic_cardiac_calcinosis2.18717374
17MP0002877_abnormal_melanocyte_morpholog2.01909308
18MP0002638_abnormal_pupillary_reflex1.99338400
19MP0001986_abnormal_taste_sensitivity1.99319297
20MP0010234_abnormal_vibrissa_follicle1.96294172
21MP0001346_abnormal_lacrimal_gland1.95376889
22MP0004270_analgesia1.95044546
23MP0000049_abnormal_middle_ear1.94812000
24MP0005248_abnormal_Harderian_gland1.93712192
25MP0000631_abnormal_neuroendocrine_gland1.92176834
26MP0002282_abnormal_trachea_morphology1.92017499
27MP0004859_abnormal_synaptic_plasticity1.87444090
28MP0001984_abnormal_olfaction1.85611002
29MP0004858_abnormal_nervous_system1.83919830
30MP0003119_abnormal_digestive_system1.81391994
31MP0001188_hyperpigmentation1.76852133
32MP0003755_abnormal_palate_morphology1.75379759
33MP0003122_maternal_imprinting1.74960668
34MP0003385_abnormal_body_wall1.74481245
35MP0003136_yellow_coat_color1.72823761
36MP0001486_abnormal_startle_reflex1.71845376
37MP0005645_abnormal_hypothalamus_physiol1.71280686
38MP0005187_abnormal_penis_morphology1.69865388
39MP0002102_abnormal_ear_morphology1.69184910
40MP0002249_abnormal_larynx_morphology1.68740593
41* MP0008789_abnormal_olfactory_epithelium1.67045254
42MP0005503_abnormal_tendon_morphology1.66596683
43* MP0005253_abnormal_eye_physiology1.61074878
44MP0002572_abnormal_emotion/affect_behav1.60883599
45MP0002928_abnormal_bile_duct1.57424441
46MP0004142_abnormal_muscle_tone1.57067771
47MP0006276_abnormal_autonomic_nervous1.56928875
48MP0002735_abnormal_chemical_nociception1.56772238
49MP0009745_abnormal_behavioral_response1.55093151
50MP0001270_distended_abdomen1.54668414
51MP0004133_heterotaxia1.52091556
52MP0003879_abnormal_hair_cell1.50090447
53* MP0002751_abnormal_autonomic_nervous1.50071027
54MP0005623_abnormal_meninges_morphology1.44826173
55MP0002254_reproductive_system_inflammat1.44388708
56MP0002876_abnormal_thyroid_physiology1.43070332
57MP0009046_muscle_twitch1.43015727
58MP0002938_white_spotting1.42628749
59MP0002653_abnormal_ependyma_morphology1.41974909
60MP0003937_abnormal_limbs/digits/tail_de1.38897032
61MP0002932_abnormal_joint_morphology1.34740078
62MP0002272_abnormal_nervous_system1.32341495
63* MP0003861_abnormal_nervous_system1.30826373
64MP0005423_abnormal_somatic_nervous1.28531288
65MP0003938_abnormal_ear_development1.25803512
66MP0005367_renal/urinary_system_phenotyp1.23689588
67MP0000516_abnormal_urinary_system1.23689588
68MP0003635_abnormal_synaptic_transmissio1.22025868
69* MP0002233_abnormal_nose_morphology1.21533473
70MP0002116_abnormal_craniofacial_bone1.21045903
71* MP0000955_abnormal_spinal_cord1.18453005
72* MP0005391_vision/eye_phenotype1.18301692
73MP0003115_abnormal_respiratory_system1.18183933
74MP0002063_abnormal_learning/memory/cond1.17826665
75MP0006292_abnormal_olfactory_placode1.17009170
76MP0002184_abnormal_innervation1.16300635
77MP0004134_abnormal_chest_morphology1.14687789
78MP0003183_abnormal_peptide_metabolism1.14280864
79MP0008961_abnormal_basal_metabolism1.13690170
80MP0004885_abnormal_endolymph1.09295310
81* MP0006072_abnormal_retinal_apoptosis1.07254838
82MP0002067_abnormal_sensory_capabilities1.06857561
83MP0003121_genomic_imprinting1.06719442
84MP0004924_abnormal_behavior1.06064302
85MP0005386_behavior/neurological_phenoty1.06064302
86MP0005646_abnormal_pituitary_gland1.04731016
87MP0001286_abnormal_eye_development1.04379112
88MP0003942_abnormal_urinary_system1.02624564
89MP0002177_abnormal_outer_ear1.02074048
90MP0002098_abnormal_vibrissa_morphology1.01852509
91* MP0002882_abnormal_neuron_morphology1.01520242
92MP0002733_abnormal_thermal_nociception1.01335768
93MP0000026_abnormal_inner_ear0.99766810
94MP0003935_abnormal_craniofacial_develop0.99604226
95MP0002089_abnormal_postnatal_growth/wei0.99437817
96MP0002114_abnormal_axial_skeleton0.99195526
97MP0003890_abnormal_embryonic-extraembry0.99166338
98MP0001968_abnormal_touch/_nociception0.98205711
99* MP0004811_abnormal_neuron_physiology0.97974113
100MP0000647_abnormal_sebaceous_gland0.97892495
101* MP0002152_abnormal_brain_morphology0.96552777
102MP0009053_abnormal_anal_canal0.96502781
103MP0004742_abnormal_vestibular_system0.95991939
104MP0000538_abnormal_urinary_bladder0.95381305
105MP0002557_abnormal_social/conspecific_i0.95318454
106MP0000428_abnormal_craniofacial_morphol0.94885658
107MP0000467_abnormal_esophagus_morphology0.93641478
108MP0002736_abnormal_nociception_after0.93565187
109MP0001502_abnormal_circadian_rhythm0.93239710
110MP0002066_abnormal_motor_capabilities/c0.93125621
111MP0002064_seizures0.93053508
112MP0000639_abnormal_adrenal_gland0.93026328
113* MP0002069_abnormal_eating/drinking_beha0.92406121
114MP0001970_abnormal_pain_threshold0.91108663
115MP0005551_abnormal_eye_electrophysiolog0.89577017
116MP0000681_abnormal_thyroid_gland0.89386000
117* MP0002081_perinatal_lethality0.87746861
118MP0003315_abnormal_perineum_morphology0.87675446
119* MP0005195_abnormal_posterior_eye0.87014416
120MP0000733_abnormal_muscle_development0.85938045
121MP0003252_abnormal_bile_duct0.85582841
122MP0002734_abnormal_mechanical_nocicepti0.84727114
123MP0001485_abnormal_pinna_reflex0.84612891
124MP0003137_abnormal_impulse_conducting0.84194060
125MP0001963_abnormal_hearing_physiology0.83983683
126* MP0001943_abnormal_respiration0.83667689
127* MP0005394_taste/olfaction_phenotype0.83309879
128* MP0005499_abnormal_olfactory_system0.83309879
129MP0004272_abnormal_basement_membrane0.82804343
130* MP0002752_abnormal_somatic_nervous0.82502663
131MP0000762_abnormal_tongue_morphology0.82044867
132MP0002697_abnormal_eye_size0.79671207
133MP0001879_abnormal_lymphatic_vessel0.77676275
134MP0003948_abnormal_gas_homeostasis0.77489133
135MP0005085_abnormal_gallbladder_physiolo0.77204557
136MP0002909_abnormal_adrenal_gland0.75955617
137MP0008872_abnormal_physiological_respon0.74265929
138MP0010678_abnormal_skin_adnexa0.74007768
139MP0002092_abnormal_eye_morphology0.73111739
140MP0001293_anophthalmia0.71102597
141MP0000678_abnormal_parathyroid_gland0.70066751
142MP0008007_abnormal_cellular_replicative0.69387126
143MP0002108_abnormal_muscle_morphology0.69232034

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the extremities (HP:0009825)4.90590016
2Aplasia involving bones of the upper limbs (HP:0009823)4.90590016
3Aplasia of the phalanges of the hand (HP:0009802)4.90590016
4Thyroid-stimulating hormone excess (HP:0002925)4.52701825
5Chorioretinal atrophy (HP:0000533)4.42556105
6Oligodactyly (hands) (HP:0001180)4.10609586
7Tongue fasciculations (HP:0001308)3.63066007
8Megalencephaly (HP:0001355)3.44286163
9Back pain (HP:0003418)3.40562641
10Intestinal atresia (HP:0011100)3.34247059
11Coronal craniosynostosis (HP:0004440)3.31514343
12Hemivertebrae (HP:0002937)3.20693972
13Anterior segment dysgenesis (HP:0007700)3.17675923
14Split foot (HP:0001839)3.14091706
15Pendular nystagmus (HP:0012043)3.09858367
16Muscle fibrillation (HP:0010546)3.06977541
17Vertebral arch anomaly (HP:0008438)3.06268646
18Medial flaring of the eyebrow (HP:0010747)3.04341656
19Germ cell neoplasia (HP:0100728)3.04040707
20Hypothermia (HP:0002045)3.03366078
21Oligodactyly (HP:0012165)3.01174403
22Hepatoblastoma (HP:0002884)2.99879636
23Adactyly (HP:0009776)2.97666647
24Hypercortisolism (HP:0001578)2.90002509
25Congenital primary aphakia (HP:0007707)2.89847326
26Specific learning disability (HP:0001328)2.86650890
27Fibular aplasia (HP:0002990)2.79464364
28Abnormality of the parathyroid morphology (HP:0011766)2.78864889
29Degeneration of anterior horn cells (HP:0002398)2.77664876
30Abnormality of the anterior horn cell (HP:0006802)2.77664876
31Progressive cerebellar ataxia (HP:0002073)2.76765963
32Aplasia/Hypoplasia of the sternum (HP:0006714)2.70305571
33Abnormality of the renal medulla (HP:0100957)2.69162043
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.68931258
35Right ventricular cardiomyopathy (HP:0011663)2.68896627
36Neonatal respiratory distress (HP:0002643)2.68835781
37Abnormality of the intervertebral disk (HP:0005108)2.68669892
38Genetic anticipation (HP:0003743)2.66692468
39True hermaphroditism (HP:0010459)2.64806644
40Abnormality of the labia minora (HP:0012880)2.61514732
41Nephrogenic diabetes insipidus (HP:0009806)2.60955622
42Hyperventilation (HP:0002883)2.60648048
43Pulmonary artery stenosis (HP:0004415)2.60138432
44Vitreoretinal degeneration (HP:0000655)2.59412435
45Renal hypoplasia (HP:0000089)2.57014463
46Abnormality of the middle phalanges of the toes (HP:0010183)2.56020677
47Tented upper lip vermilion (HP:0010804)2.53951159
48Renal dysplasia (HP:0000110)2.53544584
49Hyperthyroidism (HP:0000836)2.53032432
50Abnormality of the aortic arch (HP:0012303)2.49966801
51Drooling (HP:0002307)2.49010077
52Spinal muscular atrophy (HP:0007269)2.46059148
53Exotropia (HP:0000577)2.45123017
54Retinal dysplasia (HP:0007973)2.42581739
55Rib fusion (HP:0000902)2.40163225
56Alacrima (HP:0000522)2.38517723
57Vaginal atresia (HP:0000148)2.38408675
58Subacute progressive viral hepatitis (HP:0006572)2.37948243
59Genital tract atresia (HP:0001827)2.37265423
60Visual hallucinations (HP:0002367)2.36514737
61Meningocele (HP:0002435)2.36333429
62Increased number of teeth (HP:0011069)2.36184256
63Lissencephaly (HP:0001339)2.35924546
64Abnormality of the phalanges of the 2nd finger (HP:0009541)2.33671188
65Deviation of the hallux (HP:0010051)2.32751100
66Nephronophthisis (HP:0000090)2.29669129
67Hallux valgus (HP:0001822)2.29489857
68Thickened helices (HP:0000391)2.29268176
69Pancreatic cysts (HP:0001737)2.28356006
70Esophageal atresia (HP:0002032)2.26987554
71Excessive salivation (HP:0003781)2.26211981
72Cortical dysplasia (HP:0002539)2.25466781
73Septo-optic dysplasia (HP:0100842)2.25396218
74Molar tooth sign on MRI (HP:0002419)2.23462454
75Abnormality of midbrain morphology (HP:0002418)2.23462454
76Pancreatic fibrosis (HP:0100732)2.23244509
77Optic nerve hypoplasia (HP:0000609)2.22228246
78Thyroid carcinoma (HP:0002890)2.20079941
79Volvulus (HP:0002580)2.18746825
80Poor coordination (HP:0002370)2.17981967
81Anophthalmia (HP:0000528)2.15397098
82Type II lissencephaly (HP:0007260)2.15116474
83Overgrowth (HP:0001548)2.13582087
84Down-sloping shoulders (HP:0200021)2.13148725
85Long nose (HP:0003189)2.10660204
86Bifid scrotum (HP:0000048)2.08383978
87Curly hair (HP:0002212)2.07731064
88Anomalous pulmonary venous return (HP:0010772)2.07493776
89Pheochromocytoma (HP:0002666)2.07389222
90Abnormality of the gastric mucosa (HP:0004295)2.06668694
91Transitional cell carcinoma of the bladder (HP:0006740)2.06108574
92Gastrointestinal atresia (HP:0002589)2.06035699
93Congenital malformation of the right heart (HP:0011723)2.05593393
94Double outlet right ventricle (HP:0001719)2.05593393
95Multiple lipomas (HP:0001012)2.05424628
96Cerebellar dysplasia (HP:0007033)2.05302114
97Abnormality of the musculature of the pelvis (HP:0001469)2.04265462
98Abnormality of the hip-girdle musculature (HP:0001445)2.04265462
99Bronchomalacia (HP:0002780)2.04230786
100Esotropia (HP:0000565)2.04176157
101Pachygyria (HP:0001302)2.04124997
102Myokymia (HP:0002411)2.03530256
103Obsessive-compulsive behavior (HP:0000722)2.02021002
104Congenital sensorineural hearing impairment (HP:0008527)2.01489465
105Patellar aplasia (HP:0006443)2.00558301
106Hyperacusis (HP:0010780)1.99374054
107Bladder neoplasm (HP:0009725)1.98768822
108Bladder carcinoma (HP:0002862)1.98768822
109Broad hallux (HP:0010055)1.97660471
110Cutaneous finger syndactyly (HP:0010554)1.96774928
111Bony spicule pigmentary retinopathy (HP:0007737)1.96615850
112Tubulointerstitial nephritis (HP:0001970)1.95791939
113Absent speech (HP:0001344)1.95630443
114Limb dystonia (HP:0002451)1.95117641
115Maternal diabetes (HP:0009800)1.94919509
116Abnormality of the 2nd finger (HP:0004100)1.92720571
117Supernumerary ribs (HP:0005815)1.91251698
118Increased corneal curvature (HP:0100692)1.89477638
119Keratoconus (HP:0000563)1.89477638
120Neonatal short-limb short stature (HP:0008921)1.88372832
121Abolished electroretinogram (ERG) (HP:0000550)1.87720593
122Uterine leiomyosarcoma (HP:0002891)1.87696304
123Leiomyosarcoma (HP:0100243)1.87696304
124High anterior hairline (HP:0009890)1.86589697
125Agitation (HP:0000713)1.86570452
126Postaxial hand polydactyly (HP:0001162)1.86241330
127Abnormality of the metopic suture (HP:0005556)1.84910642
128Abnormality of the proximal phalanges of the hand (HP:0009834)1.84513625
129Broad-based gait (HP:0002136)1.84460787
130Lip pit (HP:0100267)1.84199244
131Atrophy/Degeneration involving motor neurons (HP:0007373)1.83994137
132Aplasia/Hypoplasia of the patella (HP:0006498)1.83756858
133Supernumerary bones of the axial skeleton (HP:0009144)1.83486612
134Micronodular cirrhosis (HP:0001413)1.82988643
135Large earlobe (HP:0009748)1.82900059
136Shoulder girdle muscle weakness (HP:0003547)1.82446976
137Bell-shaped thorax (HP:0001591)1.82079807
138Abnormality of the pulmonary veins (HP:0011718)1.81806040
139Tarsal synostosis (HP:0008368)1.81775109
140Neoplasm of the adrenal cortex (HP:0100641)1.81619447
141Hypsarrhythmia (HP:0002521)1.80908782
142Neoplasm of the adrenal gland (HP:0100631)1.79832721
143Natal tooth (HP:0000695)1.79401857
144Gaze-evoked nystagmus (HP:0000640)1.79249572
145Heterochromia iridis (HP:0001100)1.78834149
146Polyphagia (HP:0002591)1.78827228
147Hemiparesis (HP:0001269)1.78477441
148Asymmetry of the thorax (HP:0001555)1.77872789
149Elfin facies (HP:0004428)1.77841046
150Abnormality of the pubic bones (HP:0003172)1.77366128
151Gait imbalance (HP:0002141)1.77042759
152Preaxial hand polydactyly (HP:0001177)1.77021964
153Cutaneous syndactyly (HP:0012725)1.76911949
154Microglossia (HP:0000171)1.76506329
155Broad toe (HP:0001837)1.76482337
156Papillary thyroid carcinoma (HP:0002895)1.76230167
157Infantile muscular hypotonia (HP:0008947)1.76163115
158Increased nuchal translucency (HP:0010880)1.75917420
159Synostosis of carpal bones (HP:0005048)1.75501792
160Pterygium (HP:0001059)1.75363128
161Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75325983
162Hypoplasia of the brainstem (HP:0002365)1.75325983
163Mixed hearing impairment (HP:0000410)1.75146300
164Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74967120
165Hamartoma (HP:0010566)1.74940983
166Arnold-Chiari malformation (HP:0002308)1.73789209
167Chronic hepatic failure (HP:0100626)1.73612657
168Macroorchidism (HP:0000053)1.73389219
169Bowel incontinence (HP:0002607)1.72830997
170Aplasia/Hypoplasia of the hallux (HP:0008362)1.72570273
171Anencephaly (HP:0002323)1.72015096
172Hypoplasia of the uterus (HP:0000013)1.71489259
173Short hallux (HP:0010109)1.70874196
174Renovascular hypertension (HP:0100817)1.70321309
175Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.68407459
176Synostosis involving bones of the lower limbs (HP:0009138)1.67952818
177Synostosis involving bones of the feet (HP:0009140)1.67952818
178Decreased lacrimation (HP:0000633)1.67600747
179Symphalangism affecting the phalanges of the hand (HP:0009773)1.66966493
180Spina bifida occulta (HP:0003298)1.66088215
181Aplasia/Hypoplasia of the fibula (HP:0006492)1.65612442
182Astrocytoma (HP:0009592)1.65316166
183Abnormality of the astrocytes (HP:0100707)1.65316166
184Aqueductal stenosis (HP:0002410)1.64802249
185Cavernous hemangioma (HP:0001048)1.64406614
186Renal duplication (HP:0000075)1.64255841
187Deep philtrum (HP:0002002)1.64131270
188Absent phalangeal crease (HP:0006109)1.61774331
189Labial hypoplasia (HP:0000066)1.61489033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK196.22741347
2ERBB34.72226691
3ZAK2.97719709
4CDC72.91793258
5MAP3K42.82973338
6SRPK12.68385333
7EPHB22.65077549
8WNK32.60416757
9LIMK12.35212356
10MAP3K102.33307577
11BCR2.32670024
12CASK2.29886277
13STK38L2.19926015
14MAP4K22.11629275
15PNCK2.05032443
16SGK22.05025491
17SGK2232.02625953
18SGK4942.02625953
19NEK11.89265854
20SIK21.75064687
21INSRR1.70364568
22YES11.61275728
23DYRK21.58232601
24TRIM281.56718092
25PLK21.55398556
26BMPR21.47949009
27KSR11.43733781
28CDK81.41729898
29MAPK151.39860053
30AKT31.37735258
31SGK31.36506378
32FER1.35177425
33DYRK31.34165503
34PAK31.34052934
35CDC42BPA1.32189068
36GRK11.26377531
37BRSK11.26164619
38SCYL21.25666522
39EPHA31.25433962
40BUB11.24875558
41PRKCH1.23151931
42MELK1.21029465
43CCNB11.14773790
44LMTK21.13354178
45MINK11.11832130
46GRK51.11281278
47PRKD31.09453730
48TLK11.09190605
49TESK11.08470149
50ADRBK21.07118619
51SIK31.06668015
52FGFR31.03608194
53FRK1.03566826
54PINK11.03028455
55MKNK21.02191945
56MAP2K11.01842698
57BMPR1B1.00947458
58CSNK1G30.98167912
59MUSK0.96664668
60MARK10.95520697
61IRAK10.94765954
62DAPK20.92863228
63WEE10.92101752
64CSNK1A1L0.91752418
65CSNK1G20.90804204
66CDK30.87787886
67PAK60.87724243
68FGFR20.87209391
69NTRK20.86774838
70UHMK10.86471119
71ROCK20.85122311
72TSSK60.84298003
73MAPK130.82681051
74EPHA40.82200796
75MAP2K70.80477133
76ADRBK10.76685649
77PLK30.76372215
78DYRK1B0.76085283
79ERBB20.76051850
80PHKG20.73420019
81PHKG10.73420019
82VRK10.73287514
83RPS6KA40.71955472
84RPS6KA20.70177413
85PRKCE0.68324649
86AURKA0.67442071
87CAMK40.67161723
88TGFBR10.66725981
89CAMKK10.65864577
90CSNK1G10.65368113
91PRKCG0.62999613
92PTK20.61912769
93ROCK10.61112193
94FGFR10.59084705
95CDK11A0.58697646
96DYRK1A0.56823707
97NEK20.55787325
98MKNK10.54215209
99PAK40.53105591
100CDK90.52928350
101CHUK0.52624008
102PRKAA10.51688428
103RPS6KB10.51033153
104ICK0.50931735
105MAP2K60.50006385
106STK240.49840344
107ILK0.49431914
108DDR20.48240573
109CSNK1A10.47586911
110TNIK0.46206040
111TRIB30.45928558
112CAMK2A0.45377259
113CSNK1D0.45185263
114ATR0.43255706
115GSK3A0.42190982
116CDK60.41983835
117SGK10.41115114
118CDK180.40472558
119BRD40.40457289
120PTK60.40402830
121CDK50.39114933
122IRAK20.39089056
123PRKCZ0.38528302
124EPHB10.38303980
125TYRO30.38171227
126MAP2K40.38157380
127CSNK1E0.37740486
128CAMK2B0.37684161
129CDK140.36938103
130NTRK30.36852686
131FGFR40.36847742
132PLK10.33903343
133NUAK10.33827974
134MAPK90.33796006
135CDK150.32986324
136STK110.32587343
137TAOK10.32565192
138PRKACA0.32187008
139PKN10.32140098
140NME10.31839610
141PRKD20.31326417
142GSK3B0.30539819

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.86278908
2Axon guidance_Homo sapiens_hsa043602.79886943
3Synaptic vesicle cycle_Homo sapiens_hsa047212.59563258
4Notch signaling pathway_Homo sapiens_hsa043302.31140282
5Protein export_Homo sapiens_hsa030602.30927409
6Basal cell carcinoma_Homo sapiens_hsa052172.11394746
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.04782467
8Hippo signaling pathway_Homo sapiens_hsa043902.00943405
9Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.96881357
10Hedgehog signaling pathway_Homo sapiens_hsa043401.95011067
11Spliceosome_Homo sapiens_hsa030401.92007005
12Bladder cancer_Homo sapiens_hsa052191.87092789
13Endometrial cancer_Homo sapiens_hsa052131.84120588
14Phototransduction_Homo sapiens_hsa047441.81225261
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80081543
16Dopaminergic synapse_Homo sapiens_hsa047281.78448040
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76704019
18Dorso-ventral axis formation_Homo sapiens_hsa043201.75462267
19GABAergic synapse_Homo sapiens_hsa047271.66177269
20Melanogenesis_Homo sapiens_hsa049161.65370439
21Circadian entrainment_Homo sapiens_hsa047131.61124442
22Morphine addiction_Homo sapiens_hsa050321.59620555
23Colorectal cancer_Homo sapiens_hsa052101.57530036
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.55212467
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47088080
26Renin-angiotensin system_Homo sapiens_hsa046141.45153870
27Glutamatergic synapse_Homo sapiens_hsa047241.44495288
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44257754
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.43283629
30MicroRNAs in cancer_Homo sapiens_hsa052061.42379250
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41557357
32Oxidative phosphorylation_Homo sapiens_hsa001901.41448246
33TGF-beta signaling pathway_Homo sapiens_hsa043501.40608638
34Cholinergic synapse_Homo sapiens_hsa047251.39602645
35ErbB signaling pathway_Homo sapiens_hsa040121.39385193
36Parkinsons disease_Homo sapiens_hsa050121.38827430
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38312269
38Wnt signaling pathway_Homo sapiens_hsa043101.36876963
39Basal transcription factors_Homo sapiens_hsa030221.36318524
40Nicotine addiction_Homo sapiens_hsa050331.33799417
41Collecting duct acid secretion_Homo sapiens_hsa049661.32900237
42Cell cycle_Homo sapiens_hsa041101.31274334
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30902097
44Glioma_Homo sapiens_hsa052141.29881107
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29669745
46Sulfur metabolism_Homo sapiens_hsa009201.28264908
47Circadian rhythm_Homo sapiens_hsa047101.25553700
48Fanconi anemia pathway_Homo sapiens_hsa034601.24998401
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.22263116
50Serotonergic synapse_Homo sapiens_hsa047261.18099877
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17497959
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17492368
53Olfactory transduction_Homo sapiens_hsa047401.15645036
54Gap junction_Homo sapiens_hsa045401.15438892
55Oocyte meiosis_Homo sapiens_hsa041141.13804342
56Cocaine addiction_Homo sapiens_hsa050301.11321145
57Long-term potentiation_Homo sapiens_hsa047201.10780111
58Vibrio cholerae infection_Homo sapiens_hsa051101.10658788
59Butanoate metabolism_Homo sapiens_hsa006501.06783187
60Pancreatic cancer_Homo sapiens_hsa052121.06635641
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05552853
62Adherens junction_Homo sapiens_hsa045201.03414601
63Huntingtons disease_Homo sapiens_hsa050161.03131100
64beta-Alanine metabolism_Homo sapiens_hsa004100.99937232
65Long-term depression_Homo sapiens_hsa047300.97744278
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96361448
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96136797
68Renal cell carcinoma_Homo sapiens_hsa052110.96017301
69Alcoholism_Homo sapiens_hsa050340.95955524
70Lysine degradation_Homo sapiens_hsa003100.95415937
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94592835
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93715805
73Amphetamine addiction_Homo sapiens_hsa050310.93334968
74Melanoma_Homo sapiens_hsa052180.93032509
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92038162
76Linoleic acid metabolism_Homo sapiens_hsa005910.91321166
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.89775227
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.89363579
79mRNA surveillance pathway_Homo sapiens_hsa030150.88156385
80Cardiac muscle contraction_Homo sapiens_hsa042600.87529398
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87266148
82Tight junction_Homo sapiens_hsa045300.84320055
83Steroid biosynthesis_Homo sapiens_hsa001000.84256530
84Thyroid cancer_Homo sapiens_hsa052160.84070994
85Propanoate metabolism_Homo sapiens_hsa006400.83337070
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.82830978
87Chronic myeloid leukemia_Homo sapiens_hsa052200.82776044
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81740791
89Regulation of autophagy_Homo sapiens_hsa041400.80436720
90Non-small cell lung cancer_Homo sapiens_hsa052230.78180402
91Prostate cancer_Homo sapiens_hsa052150.77155413
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76195964
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76169033
94Fatty acid metabolism_Homo sapiens_hsa012120.75642108
95RNA polymerase_Homo sapiens_hsa030200.73525916
96Prion diseases_Homo sapiens_hsa050200.73244021
97African trypanosomiasis_Homo sapiens_hsa051430.72225725
98RNA degradation_Homo sapiens_hsa030180.72085861
99Pathways in cancer_Homo sapiens_hsa052000.69224313
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69165602
101Sulfur relay system_Homo sapiens_hsa041220.69082141
102Arginine and proline metabolism_Homo sapiens_hsa003300.68818617
103HTLV-I infection_Homo sapiens_hsa051660.68804034
104Insulin secretion_Homo sapiens_hsa049110.67853905
105GnRH signaling pathway_Homo sapiens_hsa049120.67586725
106Gastric acid secretion_Homo sapiens_hsa049710.65372545
107Proteoglycans in cancer_Homo sapiens_hsa052050.65283168
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63501292
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63350558
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.62200617
111Nitrogen metabolism_Homo sapiens_hsa009100.61276449
112MAPK signaling pathway_Homo sapiens_hsa040100.60749188
113Alzheimers disease_Homo sapiens_hsa050100.60216207
114Chemokine signaling pathway_Homo sapiens_hsa040620.59998557
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59529391
116Estrogen signaling pathway_Homo sapiens_hsa049150.59313960
117Peroxisome_Homo sapiens_hsa041460.58962433
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58517884
119Focal adhesion_Homo sapiens_hsa045100.57738493
120Ether lipid metabolism_Homo sapiens_hsa005650.57642898
121Prolactin signaling pathway_Homo sapiens_hsa049170.57205129
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56576457
123Dilated cardiomyopathy_Homo sapiens_hsa054140.55480539
124RNA transport_Homo sapiens_hsa030130.55417042
125Rap1 signaling pathway_Homo sapiens_hsa040150.55285239
126Tryptophan metabolism_Homo sapiens_hsa003800.53231795
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52652186
128Renin secretion_Homo sapiens_hsa049240.52201704
129Insulin signaling pathway_Homo sapiens_hsa049100.48743400
130Base excision repair_Homo sapiens_hsa034100.48240536
131ABC transporters_Homo sapiens_hsa020100.46341674
132FoxO signaling pathway_Homo sapiens_hsa040680.45559051
133AMPK signaling pathway_Homo sapiens_hsa041520.44227646
134Taste transduction_Homo sapiens_hsa047420.44046280
135Fatty acid degradation_Homo sapiens_hsa000710.43105907
136Ras signaling pathway_Homo sapiens_hsa040140.43096221
137Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42094072
138Oxytocin signaling pathway_Homo sapiens_hsa049210.41903101
139cAMP signaling pathway_Homo sapiens_hsa040240.40440257
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39952166
141Salivary secretion_Homo sapiens_hsa049700.39778707
142Phagosome_Homo sapiens_hsa041450.39390775
143Fat digestion and absorption_Homo sapiens_hsa049750.35639835
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35631785
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34308177
146Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33026907
147p53 signaling pathway_Homo sapiens_hsa041150.31822524

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