ASCL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.30830224
2viral transcription (GO:0019083)8.89939979
3translational termination (GO:0006415)8.62671023
4maturation of SSU-rRNA (GO:0030490)8.11679757
5ribosomal small subunit biogenesis (GO:0042274)7.99007753
6ribosomal large subunit biogenesis (GO:0042273)7.64247985
7translational elongation (GO:0006414)7.29990817
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.07037620
9protein targeting to ER (GO:0045047)6.91658879
10cotranslational protein targeting to membrane (GO:0006613)6.91645003
11cellular protein complex disassembly (GO:0043624)6.83667009
12viral life cycle (GO:0019058)6.63635123
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.57597753
14establishment of protein localization to endoplasmic reticulum (GO:0072599)6.56956205
15protein localization to endoplasmic reticulum (GO:0070972)6.46097714
16translational initiation (GO:0006413)6.37023430
17protein complex disassembly (GO:0043241)5.92300957
18regulation of respiratory burst (GO:0060263)5.60196266
19macromolecular complex disassembly (GO:0032984)5.60117958
20ribonucleoprotein complex biogenesis (GO:0022613)4.82119210
21response to peptidoglycan (GO:0032494)4.77821934
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.75268434
23positive regulation by organism of defense response of other organism involved in symbiotic interact4.75268434
24modulation by symbiont of host immune response (GO:0052553)4.75268434
25positive regulation by symbiont of host defense response (GO:0052509)4.75268434
26modulation by symbiont of host defense response (GO:0052031)4.75268434
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.75268434
28positive regulation of gamma-delta T cell activation (GO:0046645)4.69795555
29translation (GO:0006412)4.66190234
30nuclear-transcribed mRNA catabolic process (GO:0000956)4.65212922
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.64721936
32neutrophil activation involved in immune response (GO:0002283)4.58008454
33protein targeting to membrane (GO:0006612)4.56917853
34negative regulation of cell killing (GO:0031342)4.55721268
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.55721268
36mRNA catabolic process (GO:0006402)4.39413848
37DNA deamination (GO:0045006)4.30762272
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.27604497
39macrophage activation involved in immune response (GO:0002281)4.23578388
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.23398054
41negative regulation of interleukin-12 production (GO:0032695)4.20244839
42detection of other organism (GO:0098543)4.19586918
43detection of bacterium (GO:0016045)4.11866281
44positive regulation of chemokine secretion (GO:0090197)4.11219394
45RNA catabolic process (GO:0006401)4.08918341
46rRNA processing (GO:0006364)4.08585076
47regulation of chemokine secretion (GO:0090196)4.07548354
48antigen processing and presentation of endogenous antigen (GO:0019883)4.05018983
49mitotic metaphase plate congression (GO:0007080)4.00789790
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.00702134
51rRNA metabolic process (GO:0016072)3.94874837
52leukocyte aggregation (GO:0070486)3.93844830
53chromatin remodeling at centromere (GO:0031055)3.89034730
54immunoglobulin mediated immune response (GO:0016064)3.82735483
55cellular component biogenesis (GO:0044085)3.82677013
56proline biosynthetic process (GO:0006561)3.76886294
57keratinocyte proliferation (GO:0043616)3.76172416
58regulation of hydrogen peroxide metabolic process (GO:0010310)3.73165834
59DNA strand elongation involved in DNA replication (GO:0006271)3.69431268
60response to type I interferon (GO:0034340)3.69350166
61cellular response to type I interferon (GO:0071357)3.69030761
62type I interferon signaling pathway (GO:0060337)3.69030761
63positive regulation of Cdc42 GTPase activity (GO:0043089)3.67593563
64ATP synthesis coupled proton transport (GO:0015986)3.63556067
65energy coupled proton transport, down electrochemical gradient (GO:0015985)3.63556067
66metaphase plate congression (GO:0051310)3.63341852
67positive regulation of respiratory burst (GO:0060267)3.62752390
68negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.61524355
69regulation of gamma-delta T cell activation (GO:0046643)3.59069569
70DNA unwinding involved in DNA replication (GO:0006268)3.56815326
71respiratory burst (GO:0045730)3.55128492
72pseudouridine synthesis (GO:0001522)3.48743716
73DNA strand elongation (GO:0022616)3.43163587
74telomere maintenance via semi-conservative replication (GO:0032201)3.42380223
75heterochromatin organization (GO:0070828)3.42252948
76regulation of cellular extravasation (GO:0002691)3.40270659
77lipopolysaccharide-mediated signaling pathway (GO:0031663)3.39509000
78primary alcohol catabolic process (GO:0034310)3.38635281
79regulation of dendritic cell antigen processing and presentation (GO:0002604)3.37578225
80formation of translation preinitiation complex (GO:0001731)3.37137394
81neutrophil activation (GO:0042119)3.36901844
82intestinal epithelial cell development (GO:0060576)3.36834806
83granulocyte activation (GO:0036230)3.35387736
84regulation of mitochondrial translation (GO:0070129)3.35074214
85detection of external biotic stimulus (GO:0098581)3.29680985
86regulation of interferon-beta biosynthetic process (GO:0045357)3.28751683
87regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.26743154
88CENP-A containing nucleosome assembly (GO:0034080)3.25170739
89antibacterial humoral response (GO:0019731)3.24658520
90negative regulation of epidermal cell differentiation (GO:0045605)3.21292718
91antimicrobial humoral response (GO:0019730)3.21014685
92positive regulation of type 2 immune response (GO:0002830)3.19243474
93desmosome organization (GO:0002934)3.15755980
94regulation of T cell tolerance induction (GO:0002664)3.14202968
95negative regulation of epidermis development (GO:0045683)3.13678160
96establishment of protein localization to membrane (GO:0090150)3.13320457
97positive regulation of antigen processing and presentation (GO:0002579)3.12463738
98interferon-gamma-mediated signaling pathway (GO:0060333)3.12390480
99response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.08515592
100response to host immune response (GO:0052572)3.08515592
101kinetochore assembly (GO:0051382)3.08493883
102regulation of mast cell degranulation (GO:0043304)3.08040711
103NIK/NF-kappaB signaling (GO:0038061)3.05992428
104negative regulation of myeloid cell apoptotic process (GO:0033033)3.05540212
105kinetochore organization (GO:0051383)3.04955012
106telomere maintenance via telomere lengthening (GO:0010833)3.04123859
107nucleobase biosynthetic process (GO:0046112)3.03452685
108regulation of podosome assembly (GO:0071801)3.03146479
109regulation of leukocyte degranulation (GO:0043300)2.98129407
110DNA replication initiation (GO:0006270)2.97495338
111T-helper 1 type immune response (GO:0042088)2.96110834
112regulation of antigen processing and presentation (GO:0002577)2.95224346
113dendritic cell chemotaxis (GO:0002407)2.95110895
114protein targeting (GO:0006605)2.94801283
115regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.92426323
116detection of molecule of bacterial origin (GO:0032490)2.91434671
117regulation of tolerance induction (GO:0002643)2.90705023
118production of molecular mediator involved in inflammatory response (GO:0002532)2.90434584
119regulation of interferon-alpha production (GO:0032647)2.90070548
120regulation of myeloid leukocyte mediated immunity (GO:0002886)2.89613714
121respiratory electron transport chain (GO:0022904)2.89527568
122myeloid cell activation involved in immune response (GO:0002275)2.88682061
123mitotic recombination (GO:0006312)2.87084917
124macrophage activation (GO:0042116)2.86874989
125mitotic sister chromatid segregation (GO:0000070)2.86106209
126defense response to protozoan (GO:0042832)2.86062276
127purine nucleobase biosynthetic process (GO:0009113)2.85479399
128UTP biosynthetic process (GO:0006228)2.84949611
129regulation of posttranscriptional gene silencing (GO:0060147)2.84301925
130regulation of gene silencing by miRNA (GO:0060964)2.84301925
131regulation of gene silencing by RNA (GO:0060966)2.84301925
132response to muramyl dipeptide (GO:0032495)2.84195560
133establishment of protein localization to organelle (GO:0072594)2.83957480
134response to protozoan (GO:0001562)2.83861708
135positive regulation of interferon-alpha production (GO:0032727)2.82297540
136detection of biotic stimulus (GO:0009595)2.82289686
137electron transport chain (GO:0022900)2.82118891
138meiotic chromosome segregation (GO:0045132)2.81940869
139branching involved in labyrinthine layer morphogenesis (GO:0060670)2.80655155
140regulation of gamma-delta T cell differentiation (GO:0045586)2.80591708
141DNA replication checkpoint (GO:0000076)2.80550439
142trophectodermal cell differentiation (GO:0001829)2.79882211
143calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.79641906
144mitotic chromosome condensation (GO:0007076)2.78934261
145cardiovascular system development (GO:0072358)2.78546403
146interferon-gamma secretion (GO:0072643)2.78480057
147telomere maintenance via recombination (GO:0000722)2.78423322
148rRNA modification (GO:0000154)2.78043397
149negative regulation of lymphocyte mediated immunity (GO:0002707)2.76941824
150response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.76819328
151response to host (GO:0075136)2.76819328
152response to host defenses (GO:0052200)2.76819328
153bundle of His cell to Purkinje myocyte communication (GO:0086069)2.76239177
154folic acid-containing compound biosynthetic process (GO:0009396)2.75983570
155B cell mediated immunity (GO:0019724)2.75195213
156protein localization to kinetochore (GO:0034501)2.74657475
157termination of RNA polymerase III transcription (GO:0006386)2.74594311
158transcription elongation from RNA polymerase III promoter (GO:0006385)2.74594311
159germinal center formation (GO:0002467)2.74591887
160ribosome assembly (GO:0042255)2.73965498
161establishment of chromosome localization (GO:0051303)2.73921544
162negative regulation of erythrocyte differentiation (GO:0045647)2.73486403
163negative regulation of T cell mediated immunity (GO:0002710)2.73464422
164regulation of mast cell activation involved in immune response (GO:0033006)2.72296841
165spliceosomal snRNP assembly (GO:0000387)2.72202775
166ncRNA 3-end processing (GO:0043628)2.71289545
167hydrogen peroxide biosynthetic process (GO:0050665)2.70588770
168GTP biosynthetic process (GO:0006183)2.69816814
169negative regulation of telomerase activity (GO:0051974)2.69801766
170defense response to fungus (GO:0050832)2.68941716
171positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.68042506
172attachment of spindle microtubules to kinetochore (GO:0008608)2.67810791
173negative regulation of cytokine production involved in immune response (GO:0002719)2.65299169
174positive regulation of cellular amide metabolic process (GO:0034250)2.65142895
175negative regulation of leukocyte mediated immunity (GO:0002704)2.64922990
176T cell migration (GO:0072678)2.64918793
177myeloid dendritic cell differentiation (GO:0043011)2.62307246
178regulation of T-helper 2 cell differentiation (GO:0045628)2.60855115
179positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.59934936
180regulation of regulated secretory pathway (GO:1903305)2.59712506
181positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.59559819
182regulation of type 2 immune response (GO:0002828)2.56971724
183microglial cell activation (GO:0001774)2.56494186
184positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.55582167
185positive thymic T cell selection (GO:0045059)2.54915146
186positive regulation of mast cell activation (GO:0033005)2.54531291
187regulation of viral release from host cell (GO:1902186)2.54403516
188regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.54024289
189cellular extravasation (GO:0045123)2.53716623
190regulation of T cell mediated cytotoxicity (GO:0001914)2.53285090
191positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.52157818
192negative regulation of innate immune response (GO:0045824)2.51947867
193cellular response to interferon-gamma (GO:0071346)2.49647247
194positive regulation of mast cell activation involved in immune response (GO:0033008)2.47338249
195positive regulation of mast cell degranulation (GO:0043306)2.47338249
196myeloid dendritic cell activation (GO:0001773)2.47057523
197positive regulation of tolerance induction (GO:0002645)2.45574926
198regulation of T-helper 1 cell differentiation (GO:0045625)2.45230785
199response to interferon-gamma (GO:0034341)2.43822370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.88436311
2E2F7_22180533_ChIP-Seq_HELA_Human6.26016248
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.94350820
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.49991904
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.87906527
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.78407992
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.53384319
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.47758508
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.31001106
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.11609278
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11465395
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.96011283
13VDR_21846776_ChIP-Seq_THP-1_Human2.92873058
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79828768
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70466824
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.69179982
17XRN2_22483619_ChIP-Seq_HELA_Human2.67741976
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.67111744
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.64444103
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.62183993
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59725587
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.46255226
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38128827
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.37459172
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36366738
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33453900
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33199545
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.32547940
29DCP1A_22483619_ChIP-Seq_HELA_Human2.31487035
30VDR_24763502_ChIP-Seq_THP-1_Human2.30997911
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25562787
32GABP_17652178_ChIP-ChIP_JURKAT_Human2.23566298
33ESR2_21235772_ChIP-Seq_MCF-7_Human2.22468188
34LXR_22292898_ChIP-Seq_THP-1_Human2.22060054
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.18809348
36E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09717307
37* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.06901388
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06749156
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05634988
40RACK7_27058665_Chip-Seq_MCF-7_Human2.04434481
41TTF2_22483619_ChIP-Seq_HELA_Human2.02476133
42AR_21909140_ChIP-Seq_LNCAP_Human2.02089486
43SRY_22984422_ChIP-ChIP_TESTIS_Rat2.01685408
44TCF7_22412390_ChIP-Seq_EML_Mouse2.01314368
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00965578
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00026638
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98704654
48MYC_22102868_ChIP-Seq_BL_Human1.95242829
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89032297
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88840706
51SCL_19346495_ChIP-Seq_HPC-7_Human1.86429736
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86013399
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85309787
54* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85076539
55SPI1_23547873_ChIP-Seq_NB4_Human1.84660289
56MAF_26560356_Chip-Seq_TH1_Human1.83887511
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.79645992
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76139312
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.76121418
60SPI1_23127762_ChIP-Seq_K562_Human1.75940159
61* KDM2B_26808549_Chip-Seq_DND41_Human1.75781230
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73735414
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68921182
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.67772305
65* UTX_26944678_Chip-Seq_JUKART_Human1.67671290
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.67379170
67* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.67088200
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66968728
69HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.66245581
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.66026563
71VDR_23849224_ChIP-Seq_CD4+_Human1.65245880
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64867196
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62468159
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62046755
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61366058
76STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58673613
77FOXP3_21729870_ChIP-Seq_TREG_Human1.55383083
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.55159493
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.54242982
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53885602
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51855931
82* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50166573
83CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49740040
84CDX2_20551321_ChIP-Seq_CACO-2_Human1.47788103
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46738693
86RUNX1_27514584_Chip-Seq_MCF-7_Human1.46264715
87MAF_26560356_Chip-Seq_TH2_Human1.46189813
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43332339
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43281985
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42931364
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42290343
92BCL6_27268052_Chip-Seq_Bcells_Human1.42024160
93BCOR_27268052_Chip-Seq_Bcells_Human1.41133320
94* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40457739
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39630369
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37699422
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35802271
98ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35575494
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34510480
100P68_20966046_ChIP-Seq_HELA_Human1.33071340
101ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32797385
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32529627
103GABP_19822575_ChIP-Seq_HepG2_Human1.31428955
104RUNX_20019798_ChIP-Seq_JUKART_Human1.31226339
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30942301
106GATA1_19941827_ChIP-Seq_MEL_Mouse1.30828350
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30458237
108PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29364336
109RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29107182
110* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.28556265
111MYC_18940864_ChIP-ChIP_HL60_Human1.27746968
112CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27357086
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27108035
114NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26344555
115SOX2_18692474_ChIP-Seq_MEFs_Mouse1.26025329
116PPARA_22158963_ChIP-Seq_LIVER_Mouse1.25346602
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25335949
118SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25287888
119FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24912002
120MYB_26560356_Chip-Seq_TH2_Human1.24596259
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24524384
122KDM5A_27292631_Chip-Seq_BREAST_Human1.24112051
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23560829
124ELK1_22589737_ChIP-Seq_MCF10A_Human1.23021879
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22665225
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21545995
127MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21015029
128GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20234879
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19527951
130BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.19384308
131GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19276024
132SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19156808
133EGR1_19374776_ChIP-ChIP_THP-1_Human1.18799201
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17637167
135MYB_26560356_Chip-Seq_TH1_Human1.17611118
136VDR_24787735_ChIP-Seq_THP-1_Human1.17558588
137ESR1_20079471_ChIP-ChIP_T-47D_Human1.16524407
138STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15206107
139CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15176256
140NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14419485
141* SA1_27219007_Chip-Seq_ERYTHROID_Human1.12749765
142GATA6_25053715_ChIP-Seq_YYC3_Human1.12505280
143ZNF263_19887448_ChIP-Seq_K562_Human1.11760745
144* KDM2B_26808549_Chip-Seq_K562_Human1.11745481
145GATA1_19941826_ChIP-Seq_K562_Human1.11581397
146CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10912148
147GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10763203
148SMC4_20622854_ChIP-Seq_HELA_Human1.10725731
149KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10221645
150KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10221645
151KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10221645
152FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10051502
153PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09984109
154RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09961692
155* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06856417
156MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06353930
157TET1_21451524_ChIP-Seq_MESCs_Mouse1.06248879
158SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06048306
159RXR_22158963_ChIP-Seq_LIVER_Mouse1.05574759
160GATA4_25053715_ChIP-Seq_YYC3_Human1.04591835
161KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03633206
162ATF3_27146783_Chip-Seq_COLON_Human1.03575977
163* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03264593
164TCF3_18692474_ChIP-Seq_MESCs_Mouse1.02520388
165NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02208805
166MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02196753
167RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02158221
168CTCF_26484167_Chip-Seq_Bcells_Mouse1.02046061
169SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01658491
170CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01133982
171DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98695591
172ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93983165
173ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93927625
174NANOG_18692474_ChIP-Seq_MEFs_Mouse0.93197751
175NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92081167
176HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91705657
177PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90085086
178CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88646690
179SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87782973
180SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87674503
181PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86577157
182* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.85586121
183CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85343217
184FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84751898
185SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84161664
186TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83441200
187SRF_21415370_ChIP-Seq_HL-1_Mouse0.82621241
188CIITA_25753668_ChIP-Seq_RAJI_Human0.82191039
189ELK1_19687146_ChIP-ChIP_HELA_Human0.81433334
190FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.80723262
191EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.79857652
192HOXB4_20404135_ChIP-ChIP_EML_Mouse0.77034080

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.74667433
2MP0003693_abnormal_embryo_hatching4.79082893
3MP0008004_abnormal_stomach_pH4.61799906
4MP0003724_increased_susceptibility_to3.69575376
5MP0004957_abnormal_blastocyst_morpholog3.66920567
6MP0003303_peritoneal_inflammation3.64722044
7MP0003941_abnormal_skin_development3.62139702
8MP0003436_decreased_susceptibility_to3.31061762
9MP0006082_CNS_inflammation3.16442987
10MP0001835_abnormal_antigen_presentation2.97675987
11MP0009785_altered_susceptibility_to2.82005496
12MP0005671_abnormal_response_to2.78961350
13MP0005058_abnormal_lysosome_morphology2.78005704
14MP0005025_abnormal_response_to2.67124922
15MP0002148_abnormal_hypersensitivity_rea2.67092707
16MP0005451_abnormal_body_composition2.62518605
17MP0003077_abnormal_cell_cycle2.60890053
18MP0003111_abnormal_nucleus_morphology2.55740215
19MP0000462_abnormal_digestive_system2.55672283
20MP0010352_gastrointestinal_tract_polyps2.51427617
21MP0005000_abnormal_immune_tolerance2.50733488
22MP0002419_abnormal_innate_immunity2.50232452
23* MP0000490_abnormal_crypts_of2.45335348
24MP0010094_abnormal_chromosome_stability2.40646712
25MP0005387_immune_system_phenotype2.34128320
26MP0001790_abnormal_immune_system2.34128320
27MP0002796_impaired_skin_barrier2.32789890
28MP0001873_stomach_inflammation2.30935802
29MP0001800_abnormal_humoral_immune2.23042114
30MP0003191_abnormal_cellular_cholesterol2.20692030
31MP0004264_abnormal_extraembryonic_tissu2.20471276
32MP0004510_myositis2.16174712
33MP0002723_abnormal_immune_serum2.11176788
34MP0003315_abnormal_perineum_morphology2.08422254
35MP0002452_abnormal_antigen_presenting2.07378519
36MP0003453_abnormal_keratinocyte_physiol1.98642406
37MP0001819_abnormal_immune_cell1.98420677
38MP0002420_abnormal_adaptive_immunity1.97379235
39MP0000685_abnormal_immune_system1.96270567
40MP0000537_abnormal_urethra_morphology1.90733095
41MP0008932_abnormal_embryonic_tissue1.89412103
42MP0001663_abnormal_digestive_system1.88510084
43MP0002277_abnormal_respiratory_mucosa1.85999921
44MP0001533_abnormal_skeleton_physiology1.83984405
45MP0001845_abnormal_inflammatory_respons1.80148689
46MP0005310_abnormal_salivary_gland1.79540988
47MP0009278_abnormal_bone_marrow1.77497256
48MP0003172_abnormal_lysosome_physiology1.75604683
49MP0008057_abnormal_DNA_replication1.74859777
50MP0008260_abnormal_autophagy1.73702217
51MP0005381_digestive/alimentary_phenotyp1.70895452
52MP0002254_reproductive_system_inflammat1.70810239
53MP0005501_abnormal_skin_physiology1.70430029
54MP0009840_abnormal_foam_cell1.68980166
55MP0008995_early_reproductive_senescence1.67461564
56* MP0010155_abnormal_intestine_physiology1.67081862
57MP0001730_embryonic_growth_arrest1.64974520
58MP0003119_abnormal_digestive_system1.60578195
59MP0002405_respiratory_system_inflammati1.58040863
60MP0003763_abnormal_thymus_physiology1.57796124
61MP0003806_abnormal_nucleotide_metabolis1.57576220
62MP0002139_abnormal_hepatobiliary_system1.56697047
63MP0008469_abnormal_protein_level1.55552473
64MP0003786_premature_aging1.53590590
65MP0009764_decreased_sensitivity_to1.52522485
66MP0000350_abnormal_cell_proliferation1.52483846
67MP0001348_abnormal_lacrimal_gland1.52296993
68MP0003183_abnormal_peptide_metabolism1.52028034
69MP0008058_abnormal_DNA_repair1.51762753
70MP0003718_maternal_effect1.50116552
71MP0003300_gastrointestinal_ulcer1.47824119
72MP0000716_abnormal_immune_system1.46631104
73MP0008007_abnormal_cellular_replicative1.44426148
74MP0008872_abnormal_physiological_respon1.42837218
75MP0001216_abnormal_epidermal_layer1.40171226
76MP0005464_abnormal_platelet_physiology1.39882035
77* MP0003123_paternal_imprinting1.39795365
78MP0000566_synostosis1.39584986
79MP0003075_altered_response_to1.38828636
80MP0002998_abnormal_bone_remodeling1.38013831
81MP0003186_abnormal_redox_activity1.35289420
82MP0002060_abnormal_skin_morphology1.31205870
83MP0002398_abnormal_bone_marrow1.29275809
84MP0001545_abnormal_hematopoietic_system1.28042561
85MP0005397_hematopoietic_system_phenotyp1.28042561
86* MP0000477_abnormal_intestine_morphology1.26078302
87MP0001485_abnormal_pinna_reflex1.24509429
88* MP0002086_abnormal_extraembryonic_tissu1.23582198
89MP0005023_abnormal_wound_healing1.21133801
90MP0002132_abnormal_respiratory_system1.20171793
91MP0003567_abnormal_fetal_cardiomyocyte1.17049070
92MP0001697_abnormal_embryo_size1.16957555
93MP0002396_abnormal_hematopoietic_system1.16948290
94MP0002429_abnormal_blood_cell1.14302707
95MP0001849_ear_inflammation1.13901906
96MP0000613_abnormal_salivary_gland1.13708629
97MP0000470_abnormal_stomach_morphology1.12047011
98MP0010030_abnormal_orbit_morphology1.10554676
99MP0005166_decreased_susceptibility_to1.10019692
100MP0003866_abnormal_defecation1.09499984
101MP0002722_abnormal_immune_system1.09034573
102MP0000343_altered_response_to1.06602490
103MP0004858_abnormal_nervous_system1.06597139
104MP0005380_embryogenesis_phenotype1.05922577
105MP0001672_abnormal_embryogenesis/_devel1.05922577
106MP0000689_abnormal_spleen_morphology1.05686478
107MP0010771_integument_phenotype1.05103387
108MP0002098_abnormal_vibrissa_morphology1.04126202
109MP0001666_abnormal_nutrient_absorption1.04066359
110MP0003566_abnormal_cell_adhesion1.03480305
111MP0010234_abnormal_vibrissa_follicle1.03009890
112MP0000678_abnormal_parathyroid_gland1.02153748
113MP0005174_abnormal_tail_pigmentation1.00586971
114MP0003448_altered_tumor_morphology0.99842035
115MP0000604_amyloidosis0.99483243
116MP0003011_delayed_dark_adaptation0.99309867
117MP0000465_gastrointestinal_hemorrhage0.99005927
118MP0010678_abnormal_skin_adnexa0.95922413
119MP0003984_embryonic_growth_retardation0.95798689
120MP0005076_abnormal_cell_differentiation0.95647648
121MP0002166_altered_tumor_susceptibility0.95510273
122MP0001853_heart_inflammation0.94651421
123MP0002088_abnormal_embryonic_growth/wei0.94324693
124MP0000313_abnormal_cell_death0.92997207
125* MP0002080_prenatal_lethality0.92919750
126MP0003705_abnormal_hypodermis_morpholog0.92896365
127MP0004019_abnormal_vitamin_homeostasis0.91869658
128MP0004272_abnormal_basement_membrane0.91082939
129MP0002210_abnormal_sex_determination0.86209877
130MP0002019_abnormal_tumor_incidence0.85842460
131MP0001851_eye_inflammation0.85705881
132MP0002085_abnormal_embryonic_tissue0.85076184
133MP0004947_skin_inflammation0.84790398
134MP0003879_abnormal_hair_cell0.84490606
135MP0003938_abnormal_ear_development0.84412103
136MP0005390_skeleton_phenotype0.83737802
137MP0001145_abnormal_male_reproductive0.81589746
138MP0003690_abnormal_glial_cell0.77279642
139MP0008877_abnormal_DNA_methylation0.77261602
140MP0000703_abnormal_thymus_morphology0.77229602
141MP0003828_pulmonary_edema0.77138231
142MP0004197_abnormal_fetal_growth/weight/0.76946663
143MP0001664_abnormal_digestion0.76227276
144MP0002653_abnormal_ependyma_morphology0.74602404
145MP0009333_abnormal_splenocyte_physiolog0.72738765
146MP0001191_abnormal_skin_condition0.71912320
147MP0000653_abnormal_sex_gland0.71726948
148MP0002084_abnormal_developmental_patter0.71529246
149MP0003221_abnormal_cardiomyocyte_apopto0.71456276
150MP0004185_abnormal_adipocyte_glucose0.67514717
151MP0004381_abnormal_hair_follicle0.67295471
152MP0009053_abnormal_anal_canal0.67165917
153MP0000858_altered_metastatic_potential0.66296397
154MP0000609_abnormal_liver_physiology0.65991324
155MP0008874_decreased_physiological_sensi0.64943116
156MP0003795_abnormal_bone_structure0.64439425
157MP0005319_abnormal_enzyme/_coenzyme0.64433202
158MP0004883_abnormal_blood_vessel0.63561496
159MP0003878_abnormal_ear_physiology0.63199863
160MP0005377_hearing/vestibular/ear_phenot0.63199863
161MP0000383_abnormal_hair_follicle0.62912110
162MP0006054_spinal_hemorrhage0.61764267
163MP0001929_abnormal_gametogenesis0.59959948
164MP0001764_abnormal_homeostasis0.58890399
165MP0004782_abnormal_surfactant_physiolog0.58240157
166MP0001756_abnormal_urination0.57217060

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.80963195
2Ventricular fibrillation (HP:0001663)6.59146398
3Abnormal hemoglobin (HP:0011902)6.07888668
4Eczematoid dermatitis (HP:0000976)5.90183868
5Abnormality of cells of the erythroid lineage (HP:0012130)5.72965864
6Colon cancer (HP:0003003)5.46330169
7Abnormality of macrophages (HP:0004311)5.25904626
8Abnormal number of erythroid precursors (HP:0012131)5.25526122
9Recurrent abscess formation (HP:0002722)5.19778268
10Recurrent bacterial skin infections (HP:0005406)5.14772639
11Macrocytic anemia (HP:0001972)4.99306904
12Myositis (HP:0100614)4.56421282
13Orchitis (HP:0100796)4.50186812
14Pallor (HP:0000980)4.28495658
15Increased hepatocellular lipid droplets (HP:0006565)4.27874451
16Trismus (HP:0000211)4.26815205
17Increased cerebral lipofuscin (HP:0011813)4.14439163
18Retrobulbar optic neuritis (HP:0100654)4.13622081
19Optic neuritis (HP:0100653)4.13622081
20Abnormality of liposaccharide metabolism (HP:0010968)4.00447399
21Abnormality of glycosphingolipid metabolism (HP:0004343)4.00447399
22Abnormality of glycolipid metabolism (HP:0010969)4.00447399
23Oral leukoplakia (HP:0002745)3.89369315
24Aplasia/Hypoplasia of the sacrum (HP:0008517)3.88380273
25Lipid accumulation in hepatocytes (HP:0006561)3.86775674
26Recurrent gram-negative bacterial infections (HP:0005420)3.82978945
27Vacuolated lymphocytes (HP:0001922)3.76770794
28Increased neuronal autofluorescent lipopigment (HP:0002074)3.72206899
2911 pairs of ribs (HP:0000878)3.64361771
30Ileus (HP:0002595)3.61187197
31Poikiloderma (HP:0001029)3.59558230
32Abnormality of placental membranes (HP:0011409)3.47567832
33Amniotic constriction ring (HP:0009775)3.47567832
34Elevated erythrocyte sedimentation rate (HP:0003565)3.41728146
35Mediastinal lymphadenopathy (HP:0100721)3.38387843
36Systemic lupus erythematosus (HP:0002725)3.37174228
37Congenital sensorineural hearing impairment (HP:0008527)3.33152846
38Hepatocellular necrosis (HP:0001404)3.31770095
39Stomatitis (HP:0010280)3.29151926
40Keratoconjunctivitis sicca (HP:0001097)3.29053012
41Recurrent skin infections (HP:0001581)3.23554564
42Increased intramyocellular lipid droplets (HP:0012240)3.23385212
43Posterior subcapsular cataract (HP:0007787)3.21630919
44Rough bone trabeculation (HP:0100670)3.16554707
45Chronic obstructive pulmonary disease (HP:0006510)3.16141898
46Obstructive lung disease (HP:0006536)3.16141898
47Dysostosis multiplex (HP:0000943)3.11407979
48Mitochondrial inheritance (HP:0001427)3.10160580
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.03409847
50Gingivitis (HP:0000230)3.01627641
51Hepatic necrosis (HP:0002605)3.00695214
52Stenosis of the external auditory canal (HP:0000402)3.00388914
53Exertional dyspnea (HP:0002875)3.00142750
54Abnormality of the preputium (HP:0100587)2.99616312
55Recurrent fungal infections (HP:0002841)2.99599435
56Absent thumb (HP:0009777)2.96636903
57Malnutrition (HP:0004395)2.96193645
58Keratoconjunctivitis (HP:0001096)2.94385755
59Increased IgE level (HP:0003212)2.91365443
60Biliary tract neoplasm (HP:0100574)2.90521874
61Ankyloglossia (HP:0010296)2.89641099
62Increased muscle lipid content (HP:0009058)2.89110638
63Pili torti (HP:0003777)2.88507031
64Meningitis (HP:0001287)2.85716084
65Gastrointestinal infarctions (HP:0005244)2.85628330
66Increased CSF lactate (HP:0002490)2.82247053
67Amyloidosis (HP:0011034)2.81311881
68Renal Fanconi syndrome (HP:0001994)2.77857448
69Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.75380971
70Missing ribs (HP:0000921)2.74042691
71Loss of speech (HP:0002371)2.73019254
72Decreased activity of mitochondrial respiratory chain (HP:0008972)2.71545477
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.71545477
74Urticaria (HP:0001025)2.70625840
75Pustule (HP:0200039)2.69177207
76Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.68546678
77Encephalitis (HP:0002383)2.63834119
78Vasculitis (HP:0002633)2.63558773
79Gastrointestinal inflammation (HP:0004386)2.61056302
80Inflammation of the large intestine (HP:0002037)2.60012658
81Increased serum lactate (HP:0002151)2.59264279
82Increased serum ferritin (HP:0003281)2.57235500
83Disinhibition (HP:0000734)2.54471321
84J-shaped sella turcica (HP:0002680)2.52418386
85Petechiae (HP:0000967)2.49823137
86Spontaneous hematomas (HP:0007420)2.48948795
87Woolly hair (HP:0002224)2.48254340
88Right ventricular cardiomyopathy (HP:0011663)2.47981978
89Respiratory difficulties (HP:0002880)2.46792401
90Abnormal biliary tract morphology (HP:0012440)2.46385105
91Purpura (HP:0000979)2.44944632
92Hemoptysis (HP:0002105)2.44420933
93Thrombocytosis (HP:0001894)2.40465593
94Colitis (HP:0002583)2.38738975
95Abnormal trabecular bone morphology (HP:0100671)2.37602217
96Selective tooth agenesis (HP:0001592)2.37258722
97Multiple enchondromatosis (HP:0005701)2.35664759
98Abnormality of polysaccharide metabolism (HP:0011012)2.34621321
99Abnormality of glycosaminoglycan metabolism (HP:0004371)2.34621321
100Abnormality of mucopolysaccharide metabolism (HP:0011020)2.34621321
101Neoplasm of the colon (HP:0100273)2.32272126
102Rectal prolapse (HP:0002035)2.30940004
103Ridged nail (HP:0001807)2.30328082
104Axonal loss (HP:0003447)2.30277415
105Recurrent cutaneous fungal infections (HP:0011370)2.29726142
106Chronic mucocutaneous candidiasis (HP:0002728)2.29726142
107Thin bony cortex (HP:0002753)2.27970007
108Premature loss of primary teeth (HP:0006323)2.27866988
109Pulmonary infiltrates (HP:0002113)2.27719134
110Recurrent viral infections (HP:0004429)2.26889464
111Fragile nails (HP:0001808)2.26419931
112Abnormality of reticulocytes (HP:0004312)2.25649091
113Aplastic anemia (HP:0001915)2.25458899
114Mucopolysacchariduria (HP:0008155)2.25354564
115Urinary glycosaminoglycan excretion (HP:0003541)2.25354564
116Cellulitis (HP:0100658)2.24589554
117Acute necrotizing encephalopathy (HP:0006965)2.23606530
118T lymphocytopenia (HP:0005403)2.23274712
119Arterial thrombosis (HP:0004420)2.22617702
120Abnormal mitochondria in muscle tissue (HP:0008316)2.20964775
121Anorexia (HP:0002039)2.20138312
122Malignant gastrointestinal tract tumors (HP:0006749)2.19649544
123Gastrointestinal carcinoma (HP:0002672)2.19649544
124Sparse eyelashes (HP:0000653)2.18932165
125Cheilitis (HP:0100825)2.17747871
126Secondary amenorrhea (HP:0000869)2.16414896
127Cerebral hypomyelination (HP:0006808)2.16221044
128Increased IgM level (HP:0003496)2.15002314
129Abnormality of iron homeostasis (HP:0011031)2.14954253
130Xerostomia (HP:0000217)2.14089779
131Glomerulonephritis (HP:0000099)2.11284323
132Partial duplication of thumb phalanx (HP:0009944)2.11004835
133Acute encephalopathy (HP:0006846)2.08809329
134Pulmonary embolism (HP:0002204)2.08552293
135Premature ovarian failure (HP:0008209)2.07659523
136Gangrene (HP:0100758)2.07592013
137Triphalangeal thumb (HP:0001199)2.07204087
138Hypoplasia of the radius (HP:0002984)2.06321660
139Autoimmune thrombocytopenia (HP:0001973)2.05481869
140Neoplasm of the pancreas (HP:0002894)2.05409770
141Gingival bleeding (HP:0000225)2.04518963
142Plantar hyperkeratosis (HP:0007556)2.04163831
143Abnormality of T cell number (HP:0011839)2.03655568
144Hypergammaglobulinemia (HP:0010702)2.03338396
145Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.01836146
146Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01667945
147Abnormal delayed hypersensitivity skin test (HP:0002963)2.01655971
148Prolonged bleeding time (HP:0003010)2.01298431
149Hyperparathyroidism (HP:0000843)2.00286743
150Basal ganglia calcification (HP:0002135)1.99798273
151Progressive macrocephaly (HP:0004481)1.97154826
152Widely patent fontanelles and sutures (HP:0004492)1.97039442
153Ependymoma (HP:0002888)1.96827245
154Glossoptosis (HP:0000162)1.96166849
155Adenoma sebaceum (HP:0009720)1.95206870
156Angiofibromas (HP:0010615)1.95206870
157Hyperphosphaturia (HP:0003109)1.95147398
158Chronic diarrhea (HP:0002028)1.94130097
159Horseshoe kidney (HP:0000085)1.93435269
160Uterine neoplasm (HP:0010784)1.93420104
161Neoplasm of the rectum (HP:0100743)1.92551396
162Emotional lability (HP:0000712)1.92542794
163Neuronal loss in central nervous system (HP:0002529)1.91587126
164Cleft eyelid (HP:0000625)1.90670184
165Bone pain (HP:0002653)1.88923368
166Chromsome breakage (HP:0040012)1.88905416
167Polyneuropathy (HP:0001271)1.88873395
168Joint swelling (HP:0001386)1.88673188
169Acne (HP:0001061)1.88225169
170Abnormality of oral frenula (HP:0000190)1.87897003
171Nausea (HP:0002018)1.87586509
172Abnormality of urine glucose concentration (HP:0011016)1.87367880
173Glycosuria (HP:0003076)1.87367880
174Chest pain (HP:0100749)1.87357707
175Cardiomegaly (HP:0001640)1.86491859
176Tracheoesophageal fistula (HP:0002575)1.85935326
177Hypochromic anemia (HP:0001931)1.85924883
178Breast hypoplasia (HP:0003187)1.85869817
179Pathologic fracture (HP:0002756)1.84285811
180Ventricular arrhythmia (HP:0004308)1.83852716
181Interstitial pulmonary disease (HP:0006530)1.82895185
182Hemorrhage of the eye (HP:0011885)1.82710369
183Respiratory failure (HP:0002878)1.81837012
184CNS demyelination (HP:0007305)1.81704586
185Abnormality of the pleura (HP:0002103)1.81604189
186Pulmonary fibrosis (HP:0002206)1.81114739
187Progressive neurologic deterioration (HP:0002344)1.80981348
188Polygenic inheritance (HP:0010982)1.80667932
189Abnormality of the nasal mucosa (HP:0000433)1.80130651
190Congenital, generalized hypertrichosis (HP:0004540)1.79779488
191Segmental peripheral demyelination/remyelination (HP:0003481)1.79302853
192Abnormality of transition element cation homeostasis (HP:0011030)1.78776085
193Abnormal blistering of the skin (HP:0008066)1.78213057
194Conjunctival hamartoma (HP:0100780)1.77779070

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.30582202
2TRIB33.74293292
3TLK13.61852236
4EIF2AK13.19930450
5RIPK43.14306673
6MST43.07115093
7PBK3.03844073
8MAP3K113.00132498
9ERN12.99996542
10WEE12.78762187
11NME22.77609229
12MST1R2.70873490
13MAP2K62.70130087
14IRAK42.68714147
15IRAK32.68307904
16BUB12.67784534
17TTK2.64682932
18TNK22.51151265
19NME12.49924147
20CDC72.48332457
21RPS6KB22.40853211
22TESK22.32166706
23TYK22.30404443
24PRPF4B2.28595907
25NEK22.24282805
26MAP3K32.07652787
27CSK2.00717173
28VRK11.99603075
29TBK11.94762657
30MAP2K21.93414891
31ACVR1B1.86937635
32CDK121.84175433
33SMG11.82539569
34GRK61.82271870
35EPHA21.76532875
36ZAP701.75412988
37STK101.71703279
38PLK11.70368576
39MATK1.69725454
40SIK11.67414905
41IKBKE1.66014758
42AURKB1.65155821
43MAP3K141.60989111
44PTK61.57750503
45TESK11.46588010
46PRKG21.45644364
47CSF1R1.45340498
48STK391.42315119
49BTK1.36188983
50PIM21.34171047
51CDK71.31986137
52PLK41.23152250
53FGR1.21985723
54FES1.19107832
55MAP2K31.18289470
56GRK71.16751398
57LRRK21.16298862
58AURKA1.16085746
59FGFR41.14009617
60NEK11.13727564
61TGFBR11.12136472
62CDC42BPA1.10862945
63TXK1.09817963
64STK38L1.09341380
65NUAK11.09276510
66PKN21.09064279
67JAK31.08267830
68IRAK21.05949673
69MAP3K81.04261893
70TAOK21.01749114
71SIK30.98357223
72HCK0.97322689
73KIT0.93252007
74MAPKAPK30.92722597
75ITK0.92193351
76LYN0.89556150
77BRSK20.88174790
78SYK0.88099771
79EIF2AK20.85397747
80JAK20.85165725
81PDPK10.85055594
82HIPK20.84608338
83SCYL20.83945538
84FRK0.83536774
85BCKDK0.80382606
86JAK10.79497075
87CHUK0.79195031
88LCK0.77149368
89PRKD20.73559822
90PAK10.73208222
91EPHB10.72819800
92MET0.71716222
93RAF10.70169826
94PDK10.69889319
95CDK190.69436142
96MAP4K10.68640993
97EIF2AK30.67821129
98TAOK10.64612564
99PASK0.64281416
100MKNK10.63081169
101RPS6KC10.62958310
102RPS6KL10.62958310
103IRAK10.62676118
104EPHB20.61376992
105DDR20.60756095
106WNK40.60003223
107TAOK30.59295890
108MAPK110.59234861
109PRKCI0.58467655
110BMPR20.58457883
111MUSK0.58238698
112PDK30.57143193
113PDK40.57143193
114BRAF0.56936051
115SRPK10.55120885
116TSSK60.55031771
117MAP3K120.54191526
118MELK0.53605041
119MAP3K10.53035559
120TEC0.52628491
121ALK0.51654231
122DYRK30.51316988
123PAK40.50987760
124ATR0.50936962
125CHEK20.50651595
126RPS6KA60.50324518
127CSNK2A20.50248906
128MAP3K130.49968970
129RPS6KA40.49959948
130ERBB20.49861260
131CHEK10.48396260
132RPS6KA20.47038226
133MAPK150.46521111
134TGFBR20.46379853
135ILK0.45904244
136LATS20.45876384
137MAPKAPK20.44604038
138DYRK1B0.44440365
139RIPK10.43455844
140ICK0.42992292
141CSNK2A10.42077049
142CLK10.40932516
143ATM0.39988472
144MARK30.39380503
145MAP3K60.38967583
146PTK20.38310149
147CDK60.38094591
148MARK20.37985934
149DAPK20.37383133
150FYN0.37237524
151BMX0.36603148
152PLK30.36530179
153FGFR30.35506528
154CDK40.35088199
155ABL20.34938442
156BMPR1B0.34528375
157RET0.33912055
158CDK20.33817454
159CSNK1E0.33776401
160MAP3K90.33320525
161MAP2K10.33310953
162ARAF0.28920114
163EEF2K0.28480445
164MAPKAPK50.28466790
165GRK10.28200149
166STK40.27162555
167PIM10.27052530
168BLK0.25875741
169MAP3K20.25180339
170IKBKB0.23482964

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.55597397
2Mismatch repair_Homo sapiens_hsa034303.52133342
3DNA replication_Homo sapiens_hsa030303.49418889
4Homologous recombination_Homo sapiens_hsa034403.31616766
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16570740
6Other glycan degradation_Homo sapiens_hsa005112.99098591
7RNA polymerase_Homo sapiens_hsa030202.97496851
8Osteoclast differentiation_Homo sapiens_hsa043802.63906673
9Spliceosome_Homo sapiens_hsa030402.58827816
10Leishmaniasis_Homo sapiens_hsa051402.48640591
11Staphylococcus aureus infection_Homo sapiens_hsa051502.44944013
12Oxidative phosphorylation_Homo sapiens_hsa001902.42315878
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.34796745
14Proteasome_Homo sapiens_hsa030502.31751823
15Parkinsons disease_Homo sapiens_hsa050122.30270385
16Graft-versus-host disease_Homo sapiens_hsa053322.23541688
17Allograft rejection_Homo sapiens_hsa053302.22775035
18Pyrimidine metabolism_Homo sapiens_hsa002402.20220411
19Cyanoamino acid metabolism_Homo sapiens_hsa004602.15124433
20RNA transport_Homo sapiens_hsa030132.11696005
21Tuberculosis_Homo sapiens_hsa051522.01241744
22Nucleotide excision repair_Homo sapiens_hsa034201.96173731
23Huntingtons disease_Homo sapiens_hsa050161.94113843
24Autoimmune thyroid disease_Homo sapiens_hsa053201.90148825
25Lysosome_Homo sapiens_hsa041421.88955009
26Base excision repair_Homo sapiens_hsa034101.87036420
27One carbon pool by folate_Homo sapiens_hsa006701.85253719
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.82329322
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.81179377
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.80704024
31B cell receptor signaling pathway_Homo sapiens_hsa046621.78419595
32Type I diabetes mellitus_Homo sapiens_hsa049401.71822605
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.70972452
34Malaria_Homo sapiens_hsa051441.67313214
35Acute myeloid leukemia_Homo sapiens_hsa052211.67093654
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61345446
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.59677720
38TNF signaling pathway_Homo sapiens_hsa046681.58648688
39Fanconi anemia pathway_Homo sapiens_hsa034601.57872678
40Rheumatoid arthritis_Homo sapiens_hsa053231.55387033
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.52617007
42Alzheimers disease_Homo sapiens_hsa050101.52600956
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.52349104
44Asthma_Homo sapiens_hsa053101.50981746
45Primary immunodeficiency_Homo sapiens_hsa053401.50629778
46Folate biosynthesis_Homo sapiens_hsa007901.46668351
47Toxoplasmosis_Homo sapiens_hsa051451.39252671
48Measles_Homo sapiens_hsa051621.37039525
49Chemokine signaling pathway_Homo sapiens_hsa040621.36785824
50Salmonella infection_Homo sapiens_hsa051321.35472160
51T cell receptor signaling pathway_Homo sapiens_hsa046601.34362863
52Cell cycle_Homo sapiens_hsa041101.33213748
53Hematopoietic cell lineage_Homo sapiens_hsa046401.32701857
54Arachidonic acid metabolism_Homo sapiens_hsa005901.30829607
55Pentose phosphate pathway_Homo sapiens_hsa000301.28008692
56African trypanosomiasis_Homo sapiens_hsa051431.26732145
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25240717
58Glutathione metabolism_Homo sapiens_hsa004801.23574196
59Glycosaminoglycan degradation_Homo sapiens_hsa005311.21809574
60Linoleic acid metabolism_Homo sapiens_hsa005911.20373890
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19121928
62Phagosome_Homo sapiens_hsa041451.13616578
63Viral myocarditis_Homo sapiens_hsa054161.10662842
64Maturity onset diabetes of the young_Homo sapiens_hsa049501.04924538
65RNA degradation_Homo sapiens_hsa030181.03601295
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02982815
67Purine metabolism_Homo sapiens_hsa002301.00424607
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99924739
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.98732896
70Basal transcription factors_Homo sapiens_hsa030220.98706270
71Notch signaling pathway_Homo sapiens_hsa043300.97588126
72Bladder cancer_Homo sapiens_hsa052190.92326855
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92129729
74Shigellosis_Homo sapiens_hsa051310.91470685
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90807012
76Cardiac muscle contraction_Homo sapiens_hsa042600.89204847
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89172810
78Prolactin signaling pathway_Homo sapiens_hsa049170.89155668
79Hepatitis B_Homo sapiens_hsa051610.88044093
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86877240
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86262736
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.84889762
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84580640
84p53 signaling pathway_Homo sapiens_hsa041150.81307694
85Non-homologous end-joining_Homo sapiens_hsa034500.80668301
86Apoptosis_Homo sapiens_hsa042100.80077593
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.79231773
88Histidine metabolism_Homo sapiens_hsa003400.79008662
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.75962613
90Non-small cell lung cancer_Homo sapiens_hsa052230.75405029
91Thyroid cancer_Homo sapiens_hsa052160.75138325
92Arginine and proline metabolism_Homo sapiens_hsa003300.74951734
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73859821
94mRNA surveillance pathway_Homo sapiens_hsa030150.73138186
95Chronic myeloid leukemia_Homo sapiens_hsa052200.72437840
96Amoebiasis_Homo sapiens_hsa051460.72281180
97Fructose and mannose metabolism_Homo sapiens_hsa000510.71378908
98Endocytosis_Homo sapiens_hsa041440.70387547
99Endometrial cancer_Homo sapiens_hsa052130.70019112
100Collecting duct acid secretion_Homo sapiens_hsa049660.69382109
101Pancreatic cancer_Homo sapiens_hsa052120.69048784
102Sulfur metabolism_Homo sapiens_hsa009200.67015209
103Epstein-Barr virus infection_Homo sapiens_hsa051690.66144360
104Insulin resistance_Homo sapiens_hsa049310.62632235
105Protein export_Homo sapiens_hsa030600.62385264
106Systemic lupus erythematosus_Homo sapiens_hsa053220.62148695
107Vibrio cholerae infection_Homo sapiens_hsa051100.61879775
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61457633
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60238371
110Type II diabetes mellitus_Homo sapiens_hsa049300.60196950
111Basal cell carcinoma_Homo sapiens_hsa052170.59982629
112Carbon metabolism_Homo sapiens_hsa012000.59009040
113Fat digestion and absorption_Homo sapiens_hsa049750.58844738
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58492372
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57982198
116Sulfur relay system_Homo sapiens_hsa041220.56960094
117Platelet activation_Homo sapiens_hsa046110.56194564
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.56179379
119Tight junction_Homo sapiens_hsa045300.55507608
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54390869
121Renal cell carcinoma_Homo sapiens_hsa052110.52300199
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52156805
123Hepatitis C_Homo sapiens_hsa051600.48253707
124Sphingolipid metabolism_Homo sapiens_hsa006000.47864553
125Influenza A_Homo sapiens_hsa051640.47292673
126Biosynthesis of amino acids_Homo sapiens_hsa012300.47248334
127Prion diseases_Homo sapiens_hsa050200.47173823
128Metabolic pathways_Homo sapiens_hsa011000.45846144
129Pyruvate metabolism_Homo sapiens_hsa006200.45732632
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44748992
131VEGF signaling pathway_Homo sapiens_hsa043700.43409425
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.43193541
133HIF-1 signaling pathway_Homo sapiens_hsa040660.41441612
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40696978
135Caffeine metabolism_Homo sapiens_hsa002320.40366623
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.37949850
137mTOR signaling pathway_Homo sapiens_hsa041500.37809681
138Hippo signaling pathway_Homo sapiens_hsa043900.36651309
139Adherens junction_Homo sapiens_hsa045200.35063114
140Renin-angiotensin system_Homo sapiens_hsa046140.34989356
141Fatty acid degradation_Homo sapiens_hsa000710.34945976
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34945366
143beta-Alanine metabolism_Homo sapiens_hsa004100.34392437
144Nitrogen metabolism_Homo sapiens_hsa009100.33921476
145HTLV-I infection_Homo sapiens_hsa051660.33776469
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.33658401
147Oocyte meiosis_Homo sapiens_hsa041140.33422728
148Protein digestion and absorption_Homo sapiens_hsa049740.32804715
149GnRH signaling pathway_Homo sapiens_hsa049120.32016557
150Insulin signaling pathway_Homo sapiens_hsa049100.31887352
151Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31814186
152Choline metabolism in cancer_Homo sapiens_hsa052310.31489680
153Legionellosis_Homo sapiens_hsa051340.31470845
154Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31439207
155Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28976325
156Lysine degradation_Homo sapiens_hsa003100.25987816
157Colorectal cancer_Homo sapiens_hsa052100.25363827
158Intestinal immune network for IgA production_Homo sapiens_hsa046720.25138611
159Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25123409
160Ether lipid metabolism_Homo sapiens_hsa005650.24677159
161Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24622808
162Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24349429
163Herpes simplex infection_Homo sapiens_hsa051680.24199930
164Selenocompound metabolism_Homo sapiens_hsa004500.23294099
165Galactose metabolism_Homo sapiens_hsa000520.22539165
166N-Glycan biosynthesis_Homo sapiens_hsa005100.21952438
167Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21593860
168Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20932238
169Retinol metabolism_Homo sapiens_hsa008300.20696460
170Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20071634
171Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19904844
172Mineral absorption_Homo sapiens_hsa049780.18084646
173Pertussis_Homo sapiens_hsa051330.17537357
174Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16879413
175Antigen processing and presentation_Homo sapiens_hsa046120.16124106
176Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15749839
177Glycerolipid metabolism_Homo sapiens_hsa005610.15741772

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