ASCL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Basic helix-loop-helix transcription factors, such as ASCL3, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of somitogenesis (GO:0014807)9.78855596
2copper ion transport (GO:0006825)9.58593512
3transepithelial transport (GO:0070633)7.14477704
4left/right pattern formation (GO:0060972)6.95325855
5tyrosine metabolic process (GO:0006570)6.31408028
6response to copper ion (GO:0046688)5.98364315
7serotonin metabolic process (GO:0042428)5.93219580
8adenosine metabolic process (GO:0046085)5.88884251
9regulation of oxidative phosphorylation (GO:0002082)5.87264242
10sensory perception of taste (GO:0050909)5.77791945
11sodium ion homeostasis (GO:0055078)5.66297036
12sperm capacitation (GO:0048240)5.20134056
13regulation of metalloenzyme activity (GO:0048552)5.13344543
14sequestering of metal ion (GO:0051238)5.04621419
15primary amino compound metabolic process (GO:1901160)5.02765356
16cellular zinc ion homeostasis (GO:0006882)4.97834112
17tryptophan metabolic process (GO:0006568)4.84343018
18import into cell (GO:0098657)4.67739047
19norepinephrine metabolic process (GO:0042415)4.67398308
20excretion (GO:0007588)4.67352195
21positive regulation of embryonic development (GO:0040019)4.60244244
22zinc ion homeostasis (GO:0055069)4.59502876
23pyrimidine nucleoside catabolic process (GO:0046135)4.59169387
24bicarbonate transport (GO:0015701)4.59064493
25drinking behavior (GO:0042756)4.55967672
26protein localization to endosome (GO:0036010)4.16512920
27multicellular organismal water homeostasis (GO:0050891)4.08928084
28cerebellar Purkinje cell differentiation (GO:0021702)4.01574510
29membrane hyperpolarization (GO:0060081)3.99027374
30forebrain neuron development (GO:0021884)3.95687687
31ethanol oxidation (GO:0006069)3.91892756
32opioid receptor signaling pathway (GO:0038003)3.88860085
33regulation of secondary heart field cardioblast proliferation (GO:0003266)3.85960721
34regulation of cardioblast proliferation (GO:0003264)3.85960721
35ferric iron transport (GO:0015682)3.73601392
36trivalent inorganic cation transport (GO:0072512)3.73601392
37removal of superoxide radicals (GO:0019430)3.63624761
38cellular response to superoxide (GO:0071451)3.63624761
39cellular response to oxygen radical (GO:0071450)3.63624761
40establishment of mitotic spindle orientation (GO:0000132)3.63105518
41negative regulation of synaptic transmission, GABAergic (GO:0032229)3.57401182
42vasodilation (GO:0042311)3.54406810
43lysosome localization (GO:0032418)3.53461636
44negative regulation of protein oligomerization (GO:0032460)3.52784672
45indolalkylamine metabolic process (GO:0006586)3.49421574
46aldehyde catabolic process (GO:0046185)3.42383540
47intraciliary transport (GO:0042073)3.37250787
48bone remodeling (GO:0046849)3.33669187
49transferrin transport (GO:0033572)3.23954508
50sensory perception of chemical stimulus (GO:0007606)3.23143112
51cellular transition metal ion homeostasis (GO:0046916)3.19757851
52ganglion development (GO:0061548)3.19522908
53water homeostasis (GO:0030104)3.19225684
54hepatocyte apoptotic process (GO:0097284)3.17295038
55secretory granule organization (GO:0033363)3.17192548
56pancreas development (GO:0031016)3.17149406
57extracellular matrix assembly (GO:0085029)3.16483620
58indole-containing compound metabolic process (GO:0042430)3.15957663
59AMP metabolic process (GO:0046033)3.13163759
60erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.12017481
61L-phenylalanine catabolic process (GO:0006559)3.12017481
62response to pheromone (GO:0019236)3.09566808
63energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.08055981
64ATP hydrolysis coupled proton transport (GO:0015991)3.08055981
65CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.05643117
66T-helper cell differentiation (GO:0042093)3.05643117
67establishment of mitotic spindle localization (GO:0040001)3.04565041
68protein localization to cilium (GO:0061512)3.03261975
69establishment of spindle orientation (GO:0051294)3.02375796
70outer ear morphogenesis (GO:0042473)2.99770041
71regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.95793831
72regulation of intracellular pH (GO:0051453)2.93827499
73apical protein localization (GO:0045176)2.83673369
74monovalent inorganic cation homeostasis (GO:0055067)2.81865075
75phagosome maturation (GO:0090382)2.78030441
76glucosamine-containing compound catabolic process (GO:1901072)2.76151490
77regulation of cellular pH (GO:0030641)2.73682398
78regulation of female gonad development (GO:2000194)2.69239753
79response to superoxide (GO:0000303)2.69151366
80positive regulation of vasodilation (GO:0045909)2.68937693
81transition metal ion homeostasis (GO:0055076)2.68698546
82transition metal ion transport (GO:0000041)2.67276207
83glial cell proliferation (GO:0014009)2.59884403
84alpha-beta T cell differentiation involved in immune response (GO:0002293)2.59173443
85alpha-beta T cell activation involved in immune response (GO:0002287)2.59173443
86T cell differentiation involved in immune response (GO:0002292)2.59173443
87cell differentiation involved in metanephros development (GO:0072202)2.58577692
88lateral sprouting from an epithelium (GO:0060601)2.58008121
89chloride transmembrane transport (GO:1902476)2.57886686
90ethanol metabolic process (GO:0006067)2.56419981
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.56043393
92central nervous system neuron development (GO:0021954)2.55876741
93omega-hydroxylase P450 pathway (GO:0097267)2.55374222
94erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.54272838
95L-phenylalanine metabolic process (GO:0006558)2.54272838
96urinary tract smooth muscle contraction (GO:0014848)2.53549932
97cytidine deamination (GO:0009972)2.53059785
98cytidine catabolic process (GO:0006216)2.53059785
99cellular copper ion homeostasis (GO:0006878)15.2094071
100copper ion homeostasis (GO:0055070)11.3916906

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse5.48202121
2CHD7_19251738_ChIP-ChIP_MESCs_Mouse4.98578023
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.34638786
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.33219230
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.59037907
6GBX2_23144817_ChIP-Seq_PC3_Human3.18184880
7FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.73750800
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.68694222
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.57916655
10ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.51630142
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.16866088
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.15454823
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12003533
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11305013
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08566637
16TOP2B_26459242_ChIP-Seq_MCF-7_Human1.97875568
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.91751968
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.87372497
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.84260914
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83085669
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79719743
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76077987
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74280752
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74280752
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72244335
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62974218
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60451888
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59124126
29EGR1_19032775_ChIP-ChIP_M12_Human1.58418338
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55440307
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54379070
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54065702
33TP53_16413492_ChIP-PET_HCT116_Human1.53031071
34SMAD4_21799915_ChIP-Seq_A2780_Human1.41887501
35DROSHA_22980978_ChIP-Seq_HELA_Human1.38952139
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37780200
37CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36798222
38FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.36674866
39TAF15_26573619_Chip-Seq_HEK293_Human1.34865220
40P53_22127205_ChIP-Seq_FIBROBLAST_Human1.33941701
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33124126
42FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.30686931
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.27833252
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.27655244
45AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.26103643
46AHR_22903824_ChIP-Seq_MCF-7_Human1.25606389
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24842866
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.19413461
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15666279
50KDM2B_26808549_Chip-Seq_REH_Human1.14293736
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.13497405
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.12759480
53SOX2_20726797_ChIP-Seq_SW620_Human1.12157822
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.11934135
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11218675
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09733168
57FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09533147
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.09226989
59GF1_26923725_Chip-Seq_HPCs_Mouse1.08655559
60TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08654932
61TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08346131
62TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.07952808
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07571824
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06910171
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04508488
66TP53_18474530_ChIP-ChIP_U2OS_Human1.03564634
67AR_21572438_ChIP-Seq_LNCaP_Human1.03330519
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03065075
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03065075
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02823213
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02822953
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.02458872
73BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02123906
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00694315
75RNF2_27304074_Chip-Seq_ESCs_Mouse0.96828549
76SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95587051
77TCF4_23295773_ChIP-Seq_U87_Human0.95570227
78ARNT_22903824_ChIP-Seq_MCF-7_Human0.94275639
79BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94105760
80FUS_26573619_Chip-Seq_HEK293_Human0.92546777
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92087186
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90962848
83SMAD3_21741376_ChIP-Seq_HESCs_Human0.90741719
84EOMES_21245162_ChIP-Seq_HESCs_Human0.88264657
85CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87879520
86SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86814718
87POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84891090
88SMAD3_21741376_ChIP-Seq_ESCs_Human0.84502065
89NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83644498
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82138658
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81963882
92STAT3_23295773_ChIP-Seq_U87_Human0.81020827
93FOXA2_19822575_ChIP-Seq_HepG2_Human0.80969618
94BCAT_22108803_ChIP-Seq_LS180_Human0.79939682
95RUNX2_22187159_ChIP-Seq_PCA_Human0.79865044
96OCT1_27270436_Chip-Seq_PROSTATE_Human0.79727747
97TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.79101210
98SCL_19346495_ChIP-Seq_HPC-7_Human0.79097296
99FOXO3_23340844_ChIP-Seq_DLD1_Human0.78789408
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.77947096

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004885_abnormal_endolymph6.48816407
2MP0002163_abnormal_gland_morphology5.70623722
3MP0002132_abnormal_respiratory_system5.20146110
4MP0005171_absent_coat_pigmentation4.57916069
5MP0003300_gastrointestinal_ulcer4.05730868
6MP0002277_abnormal_respiratory_mucosa3.96839357
7MP0001177_atelectasis3.40129308
8MP0005379_endocrine/exocrine_gland_phen3.31452039
9MP0005408_hypopigmentation3.29884880
10MP0000372_irregular_coat_pigmentation3.23983874
11MP0004742_abnormal_vestibular_system3.05988669
12MP0001485_abnormal_pinna_reflex2.93508066
13MP0009697_abnormal_copulation2.74297095
14MP0008438_abnormal_cutaneous_collagen2.60449415
15MP0001984_abnormal_olfaction2.41314726
16MP0000371_diluted_coat_color2.40953111
17MP0005220_abnormal_exocrine_pancreas2.36369678
18MP0003329_amyloid_beta_deposits2.34027520
19MP0008872_abnormal_physiological_respon2.29498176
20MP0005503_abnormal_tendon_morphology2.28509827
21MP0008789_abnormal_olfactory_epithelium2.06125033
22MP0005499_abnormal_olfactory_system2.00139301
23MP0005394_taste/olfaction_phenotype2.00139301
24MP0000462_abnormal_digestive_system1.93836254
25MP0005377_hearing/vestibular/ear_phenot1.90878400
26MP0003878_abnormal_ear_physiology1.90878400
27MP0005275_abnormal_skin_tensile1.86976927
28MP0002089_abnormal_postnatal_growth/wei1.83358865
29MP0000613_abnormal_salivary_gland1.83035606
30MP0002098_abnormal_vibrissa_morphology1.75852778
31MP0002168_other_aberrant_phenotype1.72606139
32MP0001756_abnormal_urination1.60796259
33MP0002133_abnormal_respiratory_system1.60266796
34MP0005388_respiratory_system_phenotype1.60266796
35MP0001963_abnormal_hearing_physiology1.47426655
36MP0005395_other_phenotype1.44911536
37MP0004133_heterotaxia1.43591831
38MP0006292_abnormal_olfactory_placode1.40081541
39MP0002233_abnormal_nose_morphology1.37822329
40MP0010234_abnormal_vibrissa_follicle1.35138080
41MP0002295_abnormal_pulmonary_circulatio1.34999852
42MP0003806_abnormal_nucleotide_metabolis1.34541414
43MP0003279_aneurysm1.19623309
44MP0005636_abnormal_mineral_homeostasis1.14285735
45MP0000604_amyloidosis1.13836590
46MP0000678_abnormal_parathyroid_gland1.08103502
47MP0005248_abnormal_Harderian_gland1.02777415
48MP0002075_abnormal_coat/hair_pigmentati1.01669421
49MP0003718_maternal_effect1.01590240
50MP0004043_abnormal_pH_regulation0.98128197
51MP0001186_pigmentation_phenotype0.97228599
52MP0000733_abnormal_muscle_development0.96327314
53MP0002933_joint_inflammation0.87538851
54MP0003879_abnormal_hair_cell0.87373399
55MP0003787_abnormal_imprinting0.85914757
56MP0001663_abnormal_digestive_system0.83806953
57MP0000026_abnormal_inner_ear0.81634343
58MP0001765_abnormal_ion_homeostasis0.79257223
59MP0005646_abnormal_pituitary_gland0.79024152
60MP0000569_abnormal_digit_pigmentation0.78675938
61MP0001175_abnormal_lung_morphology0.78136114
62MP0009643_abnormal_urine_homeostasis0.77341597
63MP0000049_abnormal_middle_ear0.73554946
64MP0001270_distended_abdomen0.72464102
65MP0010386_abnormal_urinary_bladder0.71021484
66MP0001849_ear_inflammation0.70301701
67MP0002249_abnormal_larynx_morphology0.69250753
68MP0009250_abnormal_appendicular_skeleto0.67030191
69MP0002102_abnormal_ear_morphology0.61485856
70MP0003690_abnormal_glial_cell0.60911613
71MP0000681_abnormal_thyroid_gland0.60334524
72MP0001664_abnormal_digestion0.59147089
73MP0004134_abnormal_chest_morphology0.57547959
74MP0000003_abnormal_adipose_tissue0.54501196
75MP0002136_abnormal_kidney_physiology0.54233273
76MP0003195_calcinosis0.53138308
77MP0002139_abnormal_hepatobiliary_system0.52410235
78MP0000631_abnormal_neuroendocrine_gland0.51930589
79MP0002932_abnormal_joint_morphology0.51644102
80MP0002938_white_spotting0.51538711
81MP0005174_abnormal_tail_pigmentation0.50630250
82MP0005381_digestive/alimentary_phenotyp0.49948852
83MP0003632_abnormal_nervous_system0.49463469
84MP0008875_abnormal_xenobiotic_pharmacok0.49363869
85MP0001486_abnormal_startle_reflex0.49161133
86MP0008569_lethality_at_weaning0.44921062
87MP0002229_neurodegeneration0.44680318
88MP0009745_abnormal_behavioral_response0.44204806
89MP0003283_abnormal_digestive_organ0.43936006
90MP0000534_abnormal_ureter_morphology0.41819559
91MP0002177_abnormal_outer_ear0.41568015
92MP0004272_abnormal_basement_membrane0.40936425
93MP0005167_abnormal_blood-brain_barrier0.39503304
94MP0002060_abnormal_skin_morphology0.39234359
95MP0005410_abnormal_fertilization0.38641080
96MP0003186_abnormal_redox_activity0.38053526
97MP0005508_abnormal_skeleton_morphology0.37688700
98MP0004782_abnormal_surfactant_physiolog0.37196195
99MP0003938_abnormal_ear_development0.34840704
100MP0010030_abnormal_orbit_morphology0.34466653

Predicted human phenotypes

RankGene SetZ-score
1Hypokalemic alkalosis (HP:0001949)9.85006799
2Hyperactive renin-angiotensin system (HP:0000841)8.34959985
3Abnormality of chloride homeostasis (HP:0011422)8.30975625
4Morphological abnormality of the inner ear (HP:0011390)8.16376381
5Renal salt wasting (HP:0000127)8.07847270
6Hyperaldosteronism (HP:0000859)7.94526257
7Hyperkalemia (HP:0002153)6.73068145
8Decreased circulating renin level (HP:0003351)6.60602627
9Chronic bronchitis (HP:0004469)6.57797909
10Hyponatremia (HP:0002902)6.12581967
11Ileus (HP:0002595)5.84462839
12Abnormality of the right ventricle (HP:0001707)5.81860897
13Alkalosis (HP:0001948)5.44326458
14Metabolic alkalosis (HP:0200114)5.22212103
15Abnormality of sodium homeostasis (HP:0010931)5.09863345
16Conjugated hyperbilirubinemia (HP:0002908)4.84084516
17Male infertility (HP:0003251)4.83200812
18Rectal prolapse (HP:0002035)4.55850953
19Osteomalacia (HP:0002749)4.45520468
20Hypokalemia (HP:0002900)4.40659686
21Abnormality of potassium homeostasis (HP:0011042)4.08262698
22Adrenal overactivity (HP:0002717)4.01983337
23Hypothermia (HP:0002045)3.98118192
24Abnormality of renin-angiotensin system (HP:0000847)3.88286254
25Spinal muscular atrophy (HP:0007269)3.43111127
26Hypercalciuria (HP:0002150)3.15900752
27Broad ribs (HP:0000885)3.03817901
28Azoospermia (HP:0000027)2.95699115
29Tubulointerstitial nephritis (HP:0001970)2.91954631
30Spontaneous hematomas (HP:0007420)2.90133312
31Arterial tortuosity (HP:0005116)2.89206919
32Hypotension (HP:0002615)2.78632483
33Lip pit (HP:0100267)2.77677497
34Vascular calcification (HP:0004934)2.71822326
35Renal cortical cysts (HP:0000803)2.67489422
36Renal tubular dysfunction (HP:0000124)2.65935653
37Bronchitis (HP:0012387)2.64047005
38Exocrine pancreatic insufficiency (HP:0001738)2.60622069
39Polyuria (HP:0000103)2.56201008
40Bronchiectasis (HP:0002110)2.55091186
41Abnormality of the renal cortex (HP:0011035)2.53825016
42Vascular tortuosity (HP:0004948)2.51970785
43Tubulointerstitial abnormality (HP:0001969)2.46451661
44Cardiovascular calcification (HP:0011915)2.43848430
45Abnormality of Sharpey fibers (HP:0100685)2.34875083
46Abnormal urine output (HP:0012590)2.31953804
47Abnormality of the renal medulla (HP:0100957)2.29427487
48Chondrocalcinosis (HP:0000934)2.25667035
49Hyperphosphaturia (HP:0003109)2.25527059
50Dehydration (HP:0001944)2.24086038
51Esophageal varix (HP:0002040)2.22211292
52Tinnitus (HP:0000360)2.20388101
53Abnormality of renal excretion (HP:0011036)2.17458934
54Renal tubular acidosis (HP:0001947)2.12421029
55Tubulointerstitial fibrosis (HP:0005576)2.11263054
56Nephropathy (HP:0000112)2.10412844
57Metabolic acidosis (HP:0001942)2.09206337
58Stenosis of the external auditory canal (HP:0000402)2.05268531
59Abnormal spermatogenesis (HP:0008669)2.03077598
60Hip dysplasia (HP:0001385)2.01514627
61Abnormality of cochlea (HP:0000375)11.4402005
62Abnormal urine phosphate concentration (HP:0012599)1.99414019
63Hyperparathyroidism (HP:0000843)1.89231319
64Ureteral obstruction (HP:0006000)1.80179087
65Vertigo (HP:0002321)1.80099211
66Hepatitis (HP:0012115)1.79223982
67Nephrogenic diabetes insipidus (HP:0009806)1.79204078
68Nasolacrimal duct obstruction (HP:0000579)1.77336757
69Bladder diverticulum (HP:0000015)1.73919975
70Male pseudohermaphroditism (HP:0000037)1.73738337
71Goiter (HP:0000853)1.72270880
72Delayed closure of the anterior fontanelle (HP:0001476)1.70971369
73Gastrointestinal dysmotility (HP:0002579)1.62218992
74Exostoses (HP:0100777)1.58455359
75Glycosuria (HP:0003076)1.56529508
76Abnormality of urine glucose concentration (HP:0011016)1.56529508
77Asymmetry of the thorax (HP:0001555)1.53341151
78Tarsal synostosis (HP:0008368)1.51103270
79Redundant skin (HP:0001582)1.50502813
80Orthostatic hypotension (HP:0001278)1.49008026
81Tracheal stenosis (HP:0002777)1.48553979
82Aplasia involving bones of the upper limbs (HP:0009823)1.46006983
83Aplasia of the phalanges of the hand (HP:0009802)1.46006983
84Aplasia involving bones of the extremities (HP:0009825)1.46006983
85Abnormality of the nasolacrimal system (HP:0000614)1.43256034
86Short humerus (HP:0005792)1.41293453
87Enlarged kidneys (HP:0000105)1.41232896
88Synostosis involving bones of the lower limbs (HP:0009138)1.37459411
89Synostosis involving bones of the feet (HP:0009140)1.37459411
90Limited elbow extension (HP:0001377)1.37458769
91Abnormality of the lacrimal duct (HP:0011481)1.35745602
92Pulmonary fibrosis (HP:0002206)1.35544341
93Aplasia/hypoplasia of the humerus (HP:0006507)1.34031824
94Woolly hair (HP:0002224)1.32204572
95Drooling (HP:0002307)1.30533448
96Excessive salivation (HP:0003781)1.30533448
97Delayed CNS myelination (HP:0002188)1.29952473
98Abnormality of the diencephalon (HP:0010662)1.29203559
99Personality changes (HP:0000751)1.25579369
100Severe visual impairment (HP:0001141)1.23117277

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKG23.62693193
2NEK12.59349491
3LMTK215.2866204
4FRK1.96512241
5MAP3K31.62866403
6STK391.38058444
7PINK11.27069916
8ZAK1.19995241
9TAOK11.15812758
10ERBB31.12905020
11ROCK11.11224126
12BMPR21.06251055
13MAPK151.02972704
14SIK20.94573123
15MAP3K20.91862797
16NTRK30.81718435
17OXSR10.80453970
18MAP2K30.76581221
19LATS10.75190336
20CSNK1G20.68815514
21TAOK20.68381743
22STK100.68192645
23SRPK10.67353604
24WNK40.67060524
25RPS6KB20.63529521
26PAK30.61176450
27MAP3K110.60861430
28ROCK20.58793512
29ADRBK10.58558577
30PTK20.53313175
31UHMK10.52148630
32MST40.51728970
33BCR0.51576187
34IRAK20.50215682
35HIPK20.49739657
36TXK0.48864814
37PRPF4B0.47019363
38CDC42BPA0.46290854
39PRKCE0.44898068
40SIK30.42735710
41NUAK10.41798072
42PRKAA10.41561098
43STK38L0.41123175
44TNIK0.37899208
45FER0.36875130
46CDK60.36468455
47LATS20.33601634
48RIPK40.33562015
49MARK20.32260944
50PNCK0.31753383
51DAPK20.31625966
52BRD40.31317056
53ERBB20.31290061
54FGFR20.31214425
55CSNK1A1L0.31023748
56GRK60.27955083
57PDK20.27945731
58ERN10.27480507
59NEK60.26780720
60CAMK2D0.26562358
61TTK0.24422175
62MARK10.22724072
63DMPK0.22600699
64PRKG10.21496498
65PLK30.20283368
66CASK0.19265001
67PLK40.19187016
68NEK20.18964196
69BLK0.18833194
70CSNK1G30.18308684
71SGK30.17590652
72CAMK2B0.15965058
73PRKD10.15918065
74MINK10.15642526
75PRKCH0.15604148
76TYRO30.14413907
77TRPM70.14025804
78MAP2K10.13894176
79TYK20.13815947
80MARK30.13671756
81PKN10.13294686
82EIF2AK30.12344274
83CAMK10.11422507
84PRKCG0.11103359
85FGFR30.11098956
86CSNK1G10.10611501
87EIF2AK20.10180520
88CAMK2A0.09245121
89SIK10.08945906
90PRKACA0.08940750
91PRKCQ0.08856606
92PRKCA0.08288845
93EPHA40.07222932
94SGK20.06822560
95ATM0.06365427
96PRKCD0.06260944
97PLK20.05554198
98PDGFRB0.05491886
99PRKCB0.04331816
100CHUK0.03612929

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049664.54310623
2Taste transduction_Homo sapiens_hsa047424.52035768
3Vibrio cholerae infection_Homo sapiens_hsa051104.48606230
4Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.86982910
5Olfactory transduction_Homo sapiens_hsa047403.09229329
6Mineral absorption_Homo sapiens_hsa049782.81507611
7ABC transporters_Homo sapiens_hsa020102.64546180
8Synaptic vesicle cycle_Homo sapiens_hsa047212.36587442
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.31883535
10Glycerolipid metabolism_Homo sapiens_hsa005612.26288512
11Gastric acid secretion_Homo sapiens_hsa049712.18683219
12Fatty acid degradation_Homo sapiens_hsa000712.02827886
13Oxidative phosphorylation_Homo sapiens_hsa001902.02431507
14Renin secretion_Homo sapiens_hsa049241.69187982
15Sulfur metabolism_Homo sapiens_hsa009201.64425237
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.63443161
17Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.57238650
18Bile secretion_Homo sapiens_hsa049761.47548123
19Rheumatoid arthritis_Homo sapiens_hsa053231.36451402
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.29321506
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28529832
22Salivary secretion_Homo sapiens_hsa049701.25244022
23Pancreatic secretion_Homo sapiens_hsa049721.16267460
24Tyrosine metabolism_Homo sapiens_hsa003501.09986890
25beta-Alanine metabolism_Homo sapiens_hsa004101.08425673
26cAMP signaling pathway_Homo sapiens_hsa040241.04488057
27Alzheimers disease_Homo sapiens_hsa050101.04042570
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.02303984
29Other glycan degradation_Homo sapiens_hsa005111.01096129
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98901251
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96260065
32Morphine addiction_Homo sapiens_hsa050320.95508732
33Parkinsons disease_Homo sapiens_hsa050120.95349436
34Circadian entrainment_Homo sapiens_hsa047130.95174018
35cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93288920
36Phototransduction_Homo sapiens_hsa047440.89801613
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88122967
38Retinol metabolism_Homo sapiens_hsa008300.86694789
39Peroxisome_Homo sapiens_hsa041460.85425790
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85374494
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82647704
42Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81586464
43Chemical carcinogenesis_Homo sapiens_hsa052040.78259154
44Fatty acid biosynthesis_Homo sapiens_hsa000610.78029301
45Serotonergic synapse_Homo sapiens_hsa047260.75791284
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72514304
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70972311
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69428734
49Axon guidance_Homo sapiens_hsa043600.68912432
50Tryptophan metabolism_Homo sapiens_hsa003800.67706378
51Huntingtons disease_Homo sapiens_hsa050160.62726486
52Regulation of autophagy_Homo sapiens_hsa041400.62447477
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62000043
54Insulin secretion_Homo sapiens_hsa049110.60449728
55Tight junction_Homo sapiens_hsa045300.57106726
56Cholinergic synapse_Homo sapiens_hsa047250.55850349
57GABAergic synapse_Homo sapiens_hsa047270.55584421
58Glycerophospholipid metabolism_Homo sapiens_hsa005640.54515371
59Calcium signaling pathway_Homo sapiens_hsa040200.54487737
60Fatty acid metabolism_Homo sapiens_hsa012120.54390621
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52801836
62Adherens junction_Homo sapiens_hsa045200.52449919
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51798594
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51347000
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.51094340
66Long-term potentiation_Homo sapiens_hsa047200.50558020
67Platelet activation_Homo sapiens_hsa046110.50550670
68Amphetamine addiction_Homo sapiens_hsa050310.50350785
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49693504
70Dopaminergic synapse_Homo sapiens_hsa047280.48882548
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48783195
72Pyruvate metabolism_Homo sapiens_hsa006200.47896181
73Glutamatergic synapse_Homo sapiens_hsa047240.46515739
74Phagosome_Homo sapiens_hsa041450.45275150
75Vitamin B6 metabolism_Homo sapiens_hsa007500.45236336
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.43382203
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.43189174
78Proteoglycans in cancer_Homo sapiens_hsa052050.42276100
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42103311
80Starch and sucrose metabolism_Homo sapiens_hsa005000.41629719
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40548988
82PPAR signaling pathway_Homo sapiens_hsa033200.40462831
83Cardiac muscle contraction_Homo sapiens_hsa042600.38566023
84Fatty acid elongation_Homo sapiens_hsa000620.38319792
85Long-term depression_Homo sapiens_hsa047300.37205539
86Propanoate metabolism_Homo sapiens_hsa006400.36658955
87Gap junction_Homo sapiens_hsa045400.35968718
88Histidine metabolism_Homo sapiens_hsa003400.33191793
89Phenylalanine metabolism_Homo sapiens_hsa003600.31448838
90Focal adhesion_Homo sapiens_hsa045100.29126916
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29018590
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27982113
93Butanoate metabolism_Homo sapiens_hsa006500.27121590
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26671884
95Metabolic pathways_Homo sapiens_hsa011000.25303332
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25119196
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22811869
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.22189135
99Nicotine addiction_Homo sapiens_hsa050330.21988709
100Choline metabolism in cancer_Homo sapiens_hsa052310.21907604

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