ASCL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Basic helix-loop-helix transcription factors, such as ASCL4, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1serotonin receptor signaling pathway (GO:0007210)9.49082463
2negative regulation of interleukin-8 production (GO:0032717)9.01294734
3positive regulation of hair follicle development (GO:0051798)8.82141911
4positive regulation of hair cycle (GO:0042635)8.82141911
5positive regulation of osteoblast proliferation (GO:0033690)8.78656312
6angiogenesis involved in wound healing (GO:0060055)8.10101297
7regulation of appetite (GO:0032098)7.67897700
8interferon-gamma production (GO:0032609)7.42375806
9negative regulation of circadian rhythm (GO:0042754)7.30991810
10regulation of Cdc42 GTPase activity (GO:0043088)7.24028953
11negative regulation of calcium ion transport into cytosol (GO:0010523)6.91198122
12activated T cell proliferation (GO:0050798)6.81893647
13hematopoietic stem cell proliferation (GO:0071425)6.43253305
14protein K48-linked deubiquitination (GO:0071108)6.34775766
15glycoprotein catabolic process (GO:0006516)6.27013833
16protein K63-linked deubiquitination (GO:0070536)6.14093612
17lymphangiogenesis (GO:0001946)5.99223586
18regulation of hair follicle development (GO:0051797)5.90658562
19cysteine metabolic process (GO:0006534)5.53841028
20killing of cells of other organism (GO:0031640)5.46662295
21disruption of cells of other organism (GO:0044364)5.46662295
22glycerophospholipid catabolic process (GO:0046475)5.38048946
23carnitine transmembrane transport (GO:1902603)5.35454821
24sulfation (GO:0051923)5.34074684
25granulocyte differentiation (GO:0030851)5.30081586
26mucosal immune response (GO:0002385)5.23582249
27carnitine metabolic process (GO:0009437)5.18802607
28thyroid hormone metabolic process (GO:0042403)5.15047573
29carnitine transport (GO:0015879)4.89205213
30amino-acid betaine transport (GO:0015838)4.89205213
31organ or tissue specific immune response (GO:0002251)4.82074487
32phospholipid translocation (GO:0045332)4.78193656
33lipid translocation (GO:0034204)4.78193656
34filopodium assembly (GO:0046847)4.78082021
35paraxial mesoderm development (GO:0048339)4.72263534
36maturation of 5.8S rRNA (GO:0000460)4.65767433
37homocysteine metabolic process (GO:0050667)4.57377930
38negative regulation of metanephros development (GO:0072217)4.39823292
39defense response to fungus (GO:0050832)4.38934810
40organic cation transport (GO:0015695)4.30824141
41regulation of B cell receptor signaling pathway (GO:0050855)4.29560753
42spindle assembly involved in mitosis (GO:0090307)4.24565361
43ribosomal small subunit assembly (GO:0000028)4.15912646
44heparan sulfate proteoglycan metabolic process (GO:0030201)4.07393200
45flavonoid metabolic process (GO:0009812)4.05123200
46protein sumoylation (GO:0016925)4.04503649
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.03114350
48regulation of hair cycle (GO:0042634)4.01979381
49positive regulation of epidermis development (GO:0045684)3.99634826
50negative regulation of hormone biosynthetic process (GO:0032353)3.97108969
51amino-acid betaine metabolic process (GO:0006577)3.93207474
52superoxide anion generation (GO:0042554)3.81620261
53righting reflex (GO:0060013)3.81478501
54quaternary ammonium group transport (GO:0015697)3.77501278
55startle response (GO:0001964)3.76419397
56fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.72862826
57rRNA catabolic process (GO:0016075)3.72514607
58positive regulation of cAMP-mediated signaling (GO:0043950)3.72394475
59DNA deamination (GO:0045006)3.71482440
60regulation of osteoblast proliferation (GO:0033688)3.71070341
61response to peptidoglycan (GO:0032494)3.70785588
62negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.69362655
63central nervous system myelination (GO:0022010)3.68993221
64axon ensheathment in central nervous system (GO:0032291)3.68993221
65negative regulation by host of viral transcription (GO:0043922)3.68732438
663-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.67691370
67purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.67691370
68negative regulation of mast cell activation (GO:0033004)3.67287504
69facial nerve structural organization (GO:0021612)3.66568126
70regulation of sarcomere organization (GO:0060297)3.62451667
71cell killing (GO:0001906)3.59945597
72sex differentiation (GO:0007548)3.58406445
73regulation of steroid hormone biosynthetic process (GO:0090030)3.56046064
74indole-containing compound catabolic process (GO:0042436)3.52962316
75indolalkylamine catabolic process (GO:0046218)3.52962316
76tryptophan catabolic process (GO:0006569)3.52962316
77protein-cofactor linkage (GO:0018065)3.50959662
78reflex (GO:0060004)3.49622232
79negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.47713140
80mature B cell differentiation (GO:0002335)3.44529752
81negative regulation of hormone metabolic process (GO:0032351)3.43927552
82lymphoid progenitor cell differentiation (GO:0002320)3.35758004
83dosage compensation (GO:0007549)3.34645055
84myoblast migration (GO:0051451)3.33522215
85detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.33478103
86positive regulation of oligodendrocyte differentiation (GO:0048714)3.33086196
87triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.33066831
88positive regulation of vasculogenesis (GO:2001214)3.32990098
89microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.30999423
90DNA double-strand break processing (GO:0000729)3.30013618
91sex determination (GO:0007530)3.29933858
92respiratory chain complex IV assembly (GO:0008535)3.29896168
93neuron fate determination (GO:0048664)3.23211031
94cilium or flagellum-dependent cell motility (GO:0001539)3.22832207
95regulation of membrane lipid distribution (GO:0097035)3.19662006
96low-density lipoprotein particle remodeling (GO:0034374)3.19496103
97phosphatidylinositol acyl-chain remodeling (GO:0036149)3.19215509
98cytochrome complex assembly (GO:0017004)3.19053611
99synaptic vesicle docking involved in exocytosis (GO:0016081)3.18065624
100endothelial cell proliferation (GO:0001935)3.17678304
101positive regulation of blood coagulation (GO:0030194)3.16108801
102positive regulation of hemostasis (GO:1900048)3.16108801
103establishment of protein localization to Golgi (GO:0072600)3.14385234
104G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.13963388
105nuclear pore organization (GO:0006999)3.13830146
106detection of bacterium (GO:0016045)3.11974450
107detection of other organism (GO:0098543)3.10139658
108viral transcription (GO:0019083)3.06837157
109amino sugar catabolic process (GO:0046348)3.02682348
110response to fungus (GO:0009620)3.02322307
111diaphragm development (GO:0060539)2.96423352
112regulation of T-helper 1 cell differentiation (GO:0045625)2.93003236
113ribosomal small subunit biogenesis (GO:0042274)2.91677475
114translational termination (GO:0006415)2.84515834
115antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.84144601
116mature B cell differentiation involved in immune response (GO:0002313)2.84098527
117response to folic acid (GO:0051593)2.83856276
118protein heterotetramerization (GO:0051290)2.82382429
119negative regulation of homotypic cell-cell adhesion (GO:0034111)2.81758892
120regulation of pigment cell differentiation (GO:0050932)2.80961225
121positive regulation of T cell mediated cytotoxicity (GO:0001916)2.80628066
122polyketide metabolic process (GO:0030638)2.79676765
123doxorubicin metabolic process (GO:0044598)2.79676765
124daunorubicin metabolic process (GO:0044597)2.79676765
125neutrophil activation involved in immune response (GO:0002283)2.79526096
126SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.79418156
127response to interferon-beta (GO:0035456)2.74393439
128mesonephros development (GO:0001823)2.73846358
129regulation of activation of Janus kinase activity (GO:0010533)2.73734548
130platelet dense granule organization (GO:0060155)2.72097347
131defense response to protozoan (GO:0042832)2.71927304
132cotranslational protein targeting to membrane (GO:0006613)2.71843908
133mannosylation (GO:0097502)2.71019553
134protein targeting to ER (GO:0045047)2.69049423
135presynaptic membrane assembly (GO:0097105)2.67815176
136deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.67633980
137phospholipid scrambling (GO:0017121)2.67024371
138GPI anchor biosynthetic process (GO:0006506)2.65531622
139dendritic cell chemotaxis (GO:0002407)2.64013591
140DNA ligation (GO:0006266)2.63971581
141positive regulation of interleukin-1 beta secretion (GO:0050718)2.63222687
142lipoxygenase pathway (GO:0019372)2.62118522
143purinergic nucleotide receptor signaling pathway (GO:0035590)2.61533362
144cranial nerve structural organization (GO:0021604)2.58349968
145proteasome assembly (GO:0043248)2.58029654
146cellular response to exogenous dsRNA (GO:0071360)2.57500044
147positive regulation of defense response to virus by host (GO:0002230)2.57449305
148CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.54841889
149response to UV-B (GO:0010224)2.54546224
150natural killer cell activation involved in immune response (GO:0002323)2.54188486
151maturation of SSU-rRNA (GO:0030490)2.54017612
152protein localization to endoplasmic reticulum (GO:0070972)2.53667655
153N-acetylneuraminate metabolic process (GO:0006054)2.53410626
154detection of external biotic stimulus (GO:0098581)2.51555146
155regulation of timing of cell differentiation (GO:0048505)2.51381877
156postsynaptic membrane organization (GO:0001941)2.49789545
157establishment of protein localization to endoplasmic reticulum (GO:0072599)2.48114207
158positive regulation of T-helper 1 type immune response (GO:0002827)2.44690122
159tRNA methylation (GO:0030488)2.43065901
160detection of molecule of bacterial origin (GO:0032490)2.41907195
161regulation of interleukin-6 biosynthetic process (GO:0045408)2.41216154
162DNA integration (GO:0015074)2.41189410
163mast cell activation (GO:0045576)2.41085674
164positive regulation of interleukin-1 secretion (GO:0050716)2.40137022
165pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.39968199
166regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.39944044
167negative regulation of viral genome replication (GO:0045071)2.37419310
168C-terminal protein lipidation (GO:0006501)2.37045939
169regulation of T cell mediated cytotoxicity (GO:0001914)2.36883780
170regulation of RIG-I signaling pathway (GO:0039535)2.36676983
171monocyte chemotaxis (GO:0002548)2.34706877
172response to interferon-alpha (GO:0035455)2.33879090
173response to muramyl dipeptide (GO:0032495)2.31982202
174generation of neurons (GO:0048699)2.31910738
175regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.31829060
176sequestering of actin monomers (GO:0042989)2.31213924
177positive regulation of lymphocyte migration (GO:2000403)2.30746750
178negative regulation of nitric oxide biosynthetic process (GO:0045019)2.30468782
179response to protozoan (GO:0001562)2.30082360
180regulation of development, heterochronic (GO:0040034)2.29584446
181androgen biosynthetic process (GO:0006702)2.29448967
182regulation of interleukin-1 beta secretion (GO:0050706)2.28734082
183myeloid dendritic cell activation (GO:0001773)2.28704761
184positive regulation of T-helper cell differentiation (GO:0045624)2.28647782
185ribosomal large subunit biogenesis (GO:0042273)2.27741837
186definitive hemopoiesis (GO:0060216)2.27647804
187cellular response to interferon-beta (GO:0035458)2.27343318
188developmental pigmentation (GO:0048066)2.26877405
189positive regulation of cellular amide metabolic process (GO:0034250)2.26245144
190omega-hydroxylase P450 pathway (GO:0097267)2.24662934
191respiratory burst (GO:0045730)2.24285523
192negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.23983652
193viral life cycle (GO:0019058)2.21557064
194dendritic cell migration (GO:0036336)2.21409078
195positive regulation of interleukin-17 production (GO:0032740)2.21170732
196granulocyte activation (GO:0036230)2.19899966
197mesenchymal cell differentiation involved in kidney development (GO:0072161)2.19207949
198protein K11-linked deubiquitination (GO:0035871)16.3038651

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.85855420
2EZH2_22144423_ChIP-Seq_EOC_Human3.85179316
3ESR1_20079471_ChIP-ChIP_T-47D_Human3.63170248
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.59532977
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.25821475
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.10333667
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.80757065
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.79181039
9DROSHA_22980978_ChIP-Seq_HELA_Human2.78679454
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.68419960
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.67567200
12TP53_16413492_ChIP-PET_HCT116_Human2.60379604
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58229725
14AR_21572438_ChIP-Seq_LNCaP_Human2.44849921
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.43622244
16LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.42262622
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.41876129
18SCL_19346495_ChIP-Seq_HPC-7_Human2.41486621
19GBX2_23144817_ChIP-Seq_PC3_Human2.39140417
20IGF1R_20145208_ChIP-Seq_DFB_Human2.31197230
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28599171
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27023884
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.26113726
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.24966166
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24904835
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12824639
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10177626
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.02932263
29* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01196783
30ER_23166858_ChIP-Seq_MCF-7_Human2.00767461
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99633160
32IRF1_19129219_ChIP-ChIP_H3396_Human1.93677962
33LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88497276
34* AR_25329375_ChIP-Seq_VCAP_Human1.85118287
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82764484
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.73081799
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70940635
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66914962
39OCT4_21477851_ChIP-Seq_ESCs_Mouse1.65968441
40* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63624250
41FOXA1_21572438_ChIP-Seq_LNCaP_Human1.61898040
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61580823
43SMAD4_21799915_ChIP-Seq_A2780_Human1.59736426
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57883614
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56961897
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56838809
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55552879
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.53145070
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53105134
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.52836219
51P53_22387025_ChIP-Seq_ESCs_Mouse1.51389174
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.51174528
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.50233375
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49629004
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.49438708
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.48703861
57STAT3_18555785_Chip-Seq_ESCs_Mouse1.48502724
58SUZ12_18555785_Chip-Seq_ESCs_Mouse1.48194169
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45910968
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44987624
61RUNX1_27457419_Chip-Seq_LIVER_Mouse1.44745915
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.44455176
63NMYC_18555785_Chip-Seq_ESCs_Mouse1.43937531
64EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.43741496
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42930645
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.42549866
67STAT3_23295773_ChIP-Seq_U87_Human1.42354751
68* RNF2_27304074_Chip-Seq_NSC_Mouse1.42332421
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41632928
70TAF15_26573619_Chip-Seq_HEK293_Human1.41112394
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.38596733
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.38592479
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38492686
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37953920
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37306486
76TP53_22573176_ChIP-Seq_HFKS_Human1.37218999
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.36958719
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33732885
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33234695
80KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.33080949
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32543089
82VDR_22108803_ChIP-Seq_LS180_Human1.30694748
83ZNF274_21170338_ChIP-Seq_K562_Hela1.30032624
84TP53_18474530_ChIP-ChIP_U2OS_Human1.29872020
85GATA3_21878914_ChIP-Seq_MCF-7_Human1.29751909
86SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29232746
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27222938
88SPI1_23547873_ChIP-Seq_NB4_Human1.26661590
89SOX3_22085726_ChIP-Seq_MUSCLE_Mouse1.26550652
90P300_19829295_ChIP-Seq_ESCs_Human1.26044125
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.25873857
92P300_18555785_Chip-Seq_ESCs_Mouse1.25863390
93ELK1_19687146_ChIP-ChIP_HELA_Human1.24248794
94* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23692176
95TAL1_26923725_Chip-Seq_HPCs_Mouse1.23545376
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22871385
97TCF4_23295773_ChIP-Seq_U87_Human1.21791478
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.21363878
99SOX2_18555785_Chip-Seq_ESCs_Mouse1.20991982
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20452039
101OCT4_18555785_Chip-Seq_ESCs_Mouse1.20072396
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19596523
103* FLI1_21867929_ChIP-Seq_TH2_Mouse1.19586947
104* SMAD4_21741376_ChIP-Seq_EPCs_Human1.17947402
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17764236
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17070252
107PU1_27457419_Chip-Seq_LIVER_Mouse1.16392626
108KAP1_22055183_ChIP-Seq_ESCs_Mouse1.15863222
109ZFX_18555785_Chip-Seq_ESCs_Mouse1.15207750
110WDR5_24793694_ChIP-Seq_LNCAP_Human1.15203938
111GABP_17652178_ChIP-ChIP_JURKAT_Human1.15062190
112CBP_20019798_ChIP-Seq_JUKART_Human1.14451685
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14451685
114CDX2_22108803_ChIP-Seq_LS180_Human1.14428537
115* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.13908742
116CTCF_18555785_Chip-Seq_ESCs_Mouse1.13051212
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12460961
118EZH2_27304074_Chip-Seq_ESCs_Mouse1.12397077
119HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11833250
120HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11714033
121JUN_21703547_ChIP-Seq_K562_Human1.10828775
122AR_19668381_ChIP-Seq_PC3_Human1.10398823
123SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08931397
124KLF4_18555785_Chip-Seq_ESCs_Mouse1.08703558
125ESRRB_18555785_Chip-Seq_ESCs_Mouse1.08439775
126SMAD1_18555785_Chip-Seq_ESCs_Mouse1.08169551
127SPI1_23127762_ChIP-Seq_K562_Human1.06311623
128PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04839143
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04534798
130SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03858345
131EED_16625203_ChIP-ChIP_MESCs_Mouse1.03758971
132PHF8_20622853_ChIP-Seq_HELA_Human1.03689823
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03535164
134STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03404571
135SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03083921
136EWS_26573619_Chip-Seq_HEK293_Human1.01191354
137CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99926901
138ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99840647
139PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99439934
140* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99172177
141FUS_26573619_Chip-Seq_HEK293_Human0.99096668
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.98751456
143REST_21632747_ChIP-Seq_MESCs_Mouse0.98618138
144IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98567153
145* RUNX2_22187159_ChIP-Seq_PCA_Human0.95748814
146PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95676761
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95282422
148STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.94991667
149HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94971658
150POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94600499
151EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94455367
152EST1_17652178_ChIP-ChIP_JURKAT_Human0.94386037
153TCF4_22108803_ChIP-Seq_LS180_Human0.94308150
154SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93126959
155BRD4_25478319_ChIP-Seq_HGPS_Human0.92811808
156ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92409034
157SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.92116222
158JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91834733
159DCP1A_22483619_ChIP-Seq_HELA_Human0.91774966
160SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91592811
161STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.90196668
162GATA3_21867929_ChIP-Seq_TH1_Mouse0.90084112
163ESET_19884257_ChIP-Seq_ESCs_Mouse0.89299622
164P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87835500
165FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87652531
166FOXA1_25329375_ChIP-Seq_VCAP_Human0.87652531
167ERG_20517297_ChIP-Seq_VCAP_Human0.87563044
168MYC_18940864_ChIP-ChIP_HL60_Human0.87512366
169AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85463933
170STAT1_20625510_ChIP-Seq_HELA_Human0.85221770
171GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85084051
172CTCF_20526341_ChIP-Seq_ESCs_Human0.84325862
173CJUN_26792858_Chip-Seq_BT549_Human0.84266456
174DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84193379
175SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83474880
176* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.83439737
177KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82752167

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism8.54733344
2MP0002138_abnormal_hepatobiliary_system5.18339248
3MP0005670_abnormal_white_adipose4.82123869
4MP0005310_abnormal_salivary_gland4.70870030
5MP0008875_abnormal_xenobiotic_pharmacok4.49312215
6MP0003136_yellow_coat_color4.22837333
7MP0002139_abnormal_hepatobiliary_system4.12116606
8MP0003806_abnormal_nucleotide_metabolis3.96925819
9MP0006292_abnormal_olfactory_placode3.81738901
10MP0009379_abnormal_foot_pigmentation3.77222299
11MP0002254_reproductive_system_inflammat3.57688751
12MP0001188_hyperpigmentation3.38804499
13MP0005174_abnormal_tail_pigmentation3.21258903
14MP0000015_abnormal_ear_pigmentation2.84753967
15MP0002148_abnormal_hypersensitivity_rea2.76958311
16MP0004381_abnormal_hair_follicle2.76818470
17MP0004043_abnormal_pH_regulation2.70013851
18MP0000372_irregular_coat_pigmentation2.61115942
19MP0001986_abnormal_taste_sensitivity2.60743152
20MP0005409_darkened_coat_color2.58947650
21MP0009785_altered_susceptibility_to2.57479092
22MP0001835_abnormal_antigen_presentation2.55126251
23MP0003724_increased_susceptibility_to2.45867447
24MP0005075_abnormal_melanosome_morpholog2.25404054
25MP0002638_abnormal_pupillary_reflex2.20297977
26MP0001879_abnormal_lymphatic_vessel2.07915055
27MP0005671_abnormal_response_to2.02015405
28MP0001873_stomach_inflammation1.97855285
29MP0005389_reproductive_system_phenotype1.95677490
30MP0005647_abnormal_sex_gland1.94784083
31MP0002095_abnormal_skin_pigmentation1.86818328
32MP0002277_abnormal_respiratory_mucosa1.79507958
33MP0002876_abnormal_thyroid_physiology1.79137592
34MP0005025_abnormal_response_to1.76426934
35MP0001348_abnormal_lacrimal_gland1.73992980
36MP0005000_abnormal_immune_tolerance1.67595155
37MP0005171_absent_coat_pigmentation1.64600237
38MP0005551_abnormal_eye_electrophysiolog1.63888776
39MP0002419_abnormal_innate_immunity1.63660351
40MP0002938_white_spotting1.63344007
41MP0002970_abnormal_white_adipose1.63337605
42MP0002064_seizures1.57782520
43MP0003763_abnormal_thymus_physiology1.56074753
44MP0005187_abnormal_penis_morphology1.54085765
45MP0002928_abnormal_bile_duct1.52890861
46MP0000569_abnormal_digit_pigmentation1.49978406
47MP0002452_abnormal_antigen_presenting1.49316362
48MP0001346_abnormal_lacrimal_gland1.49308505
49MP0001800_abnormal_humoral_immune1.46928083
50MP0002723_abnormal_immune_serum1.44535732
51MP0000230_abnormal_systemic_arterial1.41202332
52MP0004858_abnormal_nervous_system1.40076355
53MP0002132_abnormal_respiratory_system1.38942663
54MP0009046_muscle_twitch1.38850346
55MP0001819_abnormal_immune_cell1.38815028
56MP0002420_abnormal_adaptive_immunity1.38441188
57MP0003436_decreased_susceptibility_to1.38394586
58MP0003880_abnormal_central_pattern1.36470631
59MP0003315_abnormal_perineum_morphology1.35657105
60MP0000685_abnormal_immune_system1.35302764
61MP0000681_abnormal_thyroid_gland1.33365813
62MP0002735_abnormal_chemical_nociception1.33161173
63MP0009745_abnormal_behavioral_response1.27736014
64MP0005464_abnormal_platelet_physiology1.27641082
65MP0006276_abnormal_autonomic_nervous1.27014849
66MP0001790_abnormal_immune_system1.26784441
67MP0005387_immune_system_phenotype1.26784441
68MP0002163_abnormal_gland_morphology1.23688767
69MP0002102_abnormal_ear_morphology1.22932525
70MP0001905_abnormal_dopamine_level1.22237137
71MP0005645_abnormal_hypothalamus_physiol1.22081506
72MP0001853_heart_inflammation1.21621219
73MP0008260_abnormal_autophagy1.21456543
74MP0000566_synostosis1.19720182
75MP0008058_abnormal_DNA_repair1.18276950
76MP0005084_abnormal_gallbladder_morpholo1.18203317
77MP0003638_abnormal_response/metabolism_1.17622141
78MP0008961_abnormal_basal_metabolism1.16090835
79MP0004142_abnormal_muscle_tone1.15531225
80MP0000049_abnormal_middle_ear1.12881305
81MP0000490_abnormal_crypts_of1.09420390
82MP0004782_abnormal_surfactant_physiolog1.09041185
83MP0005360_urolithiasis1.08970223
84MP0002751_abnormal_autonomic_nervous1.08557870
85MP0004742_abnormal_vestibular_system1.08055720
86MP0008789_abnormal_olfactory_epithelium1.07280551
87MP0009697_abnormal_copulation1.06774289
88MP0009764_decreased_sensitivity_to1.06209781
89MP0002177_abnormal_outer_ear1.04127428
90MP0001968_abnormal_touch/_nociception1.02278850
91MP0003941_abnormal_skin_development1.02274865
92MP0002127_abnormal_cardiovascular_syste1.02162741
93MP0005167_abnormal_blood-brain_barrier1.01584484
94MP0006082_CNS_inflammation1.00955405
95MP0002396_abnormal_hematopoietic_system1.00175097
96MP0000716_abnormal_immune_system1.00162130
97MP0002398_abnormal_bone_marrow1.00133100
98MP0001984_abnormal_olfaction0.99572822
99MP0010386_abnormal_urinary_bladder0.99546767
100MP0009333_abnormal_splenocyte_physiolog0.99041888
101MP0005379_endocrine/exocrine_gland_phen0.98765154
102MP0002269_muscular_atrophy0.98474349
103MP0008004_abnormal_stomach_pH0.96463551
104MP0001486_abnormal_startle_reflex0.95961511
105MP0003693_abnormal_embryo_hatching0.95630236
106MP0001186_pigmentation_phenotype0.95350810
107MP0004147_increased_porphyrin_level0.94675417
108MP0000026_abnormal_inner_ear0.94248378
109MP0000383_abnormal_hair_follicle0.92565517
110MP0010155_abnormal_intestine_physiology0.92154241
111MP0003879_abnormal_hair_cell0.91785207
112MP0001970_abnormal_pain_threshold0.91127709
113MP0000465_gastrointestinal_hemorrhage0.90072073
114MP0002736_abnormal_nociception_after0.89920717
115MP0010329_abnormal_lipoprotein_level0.88811863
116MP0002971_abnormal_brown_adipose0.88680805
117MP0002075_abnormal_coat/hair_pigmentati0.88113200
118MP0000678_abnormal_parathyroid_gland0.87085712
119MP0005646_abnormal_pituitary_gland0.87063416
120MP0001845_abnormal_inflammatory_respons0.87045650
121MP0002572_abnormal_emotion/affect_behav0.86901925
122MP0003936_abnormal_reproductive_system0.86523495
123MP0001764_abnormal_homeostasis0.84509572
124MP0008995_early_reproductive_senescence0.83064622
125MP0002405_respiratory_system_inflammati0.81752384
126MP0002249_abnormal_larynx_morphology0.81374642
127MP0002160_abnormal_reproductive_system0.80944123
128MP0001963_abnormal_hearing_physiology0.80605224
129MP0001919_abnormal_reproductive_system0.80072477
130MP0002429_abnormal_blood_cell0.78932423
131MP0000639_abnormal_adrenal_gland0.78800310
132MP0008569_lethality_at_weaning0.76716864
133MP0000689_abnormal_spleen_morphology0.75786485
134MP0002234_abnormal_pharynx_morphology0.75042098
135MP0001545_abnormal_hematopoietic_system0.74882164
136MP0005397_hematopoietic_system_phenotyp0.74882164
137MP0003646_muscle_fatigue0.74485893
138MP0003786_premature_aging0.73043333
139MP0005452_abnormal_adipose_tissue0.71254039
140MP0005377_hearing/vestibular/ear_phenot0.71016941
141MP0003878_abnormal_ear_physiology0.71016941
142MP0002006_tumorigenesis0.70492482
143MP0002722_abnormal_immune_system0.69961581
144MP0000613_abnormal_salivary_gland0.69413315
145MP0000371_diluted_coat_color0.69276234
146MP0000858_altered_metastatic_potential0.69223790
147MP0002998_abnormal_bone_remodeling0.69059399
148MP0003011_delayed_dark_adaptation0.68792556
149MP0005595_abnormal_vascular_smooth0.68681263
150MP0010678_abnormal_skin_adnexa0.67875544
151MP0008874_decreased_physiological_sensi0.65836106
152MP0005332_abnormal_amino_acid0.62244654
153MP0003195_calcinosis0.61549699
154MP0002734_abnormal_mechanical_nocicepti0.60631347
155MP0002272_abnormal_nervous_system0.57367322
156MP0000631_abnormal_neuroendocrine_gland0.57356949
157MP0002118_abnormal_lipid_homeostasis0.55434078
158MP0003632_abnormal_nervous_system0.54908232
159MP0009278_abnormal_bone_marrow0.53992344
160MP0001663_abnormal_digestive_system0.51851843
161MP0009643_abnormal_urine_homeostasis0.51725198
162MP0001440_abnormal_grooming_behavior0.51551740
163MP0001299_abnormal_eye_distance/0.49948287
164MP0009642_abnormal_blood_homeostasis0.49704333
165MP0005448_abnormal_energy_balance0.49569270
166MP0002069_abnormal_eating/drinking_beha0.47494717
167MP0003252_abnormal_bile_duct0.46759616
168MP0005253_abnormal_eye_physiology0.46705814
169MP0002229_neurodegeneration0.46208046
170MP0002063_abnormal_learning/memory/cond0.46019228
171MP0008469_abnormal_protein_level0.45631533
172MP0005666_abnormal_adipose_tissue0.45090782
173MP0004085_abnormal_heartbeat0.44754925
174MP0002210_abnormal_sex_determination0.44716669

Predicted human phenotypes

RankGene SetZ-score
1Lower limb hyperreflexia (HP:0002395)6.24568539
2Bilateral sensorineural hearing impairment (HP:0008619)5.61953797
3Keratoconjunctivitis (HP:0001096)5.36511028
4Poikiloderma (HP:0001029)5.04378387
5Type I transferrin isoform profile (HP:0003642)4.79203287
6Decreased circulating renin level (HP:0003351)4.72627760
7Reduced antithrombin III activity (HP:0001976)4.53751434
8Hypothermia (HP:0002045)4.36560728
9Abnormal pancreas size (HP:0012094)4.33178282
10Abnormality of the pericardium (HP:0001697)4.07498835
11Keratoconjunctivitis sicca (HP:0001097)4.06587470
12Enlarged penis (HP:0000040)3.96981936
13Hypoplasia of the uterus (HP:0000013)3.94792068
14Abolished electroretinogram (ERG) (HP:0000550)3.94528262
15Gout (HP:0001997)3.59693119
16Congenital stationary night blindness (HP:0007642)3.50719165
17Unilateral renal agenesis (HP:0000122)3.44412792
18Hyperglycinuria (HP:0003108)3.43320591
19Tinnitus (HP:0000360)3.25329691
20Abnormal glycosylation (HP:0012345)3.15402730
21Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.15402730
22Abnormal protein N-linked glycosylation (HP:0012347)3.15402730
23Abnormal protein glycosylation (HP:0012346)3.15402730
24Recurrent abscess formation (HP:0002722)3.14212326
25Type 2 muscle fiber atrophy (HP:0003554)3.13420770
26Bony spicule pigmentary retinopathy (HP:0007737)3.10579244
27Mediastinal lymphadenopathy (HP:0100721)3.05933482
28True hermaphroditism (HP:0010459)3.00240864
29Abnormality of dentin (HP:0010299)2.97755803
30Nonprogressive disorder (HP:0003680)2.94819855
31Muscle fiber atrophy (HP:0100295)2.92096132
32Abnormality of cells of the erythroid lineage (HP:0012130)2.90049371
33Xanthomatosis (HP:0000991)2.86492007
34Late onset (HP:0003584)2.85467946
35Thyroid-stimulating hormone excess (HP:0002925)2.83501419
36Absent rod-and cone-mediated responses on ERG (HP:0007688)2.82529973
37Hyperventilation (HP:0002883)2.82311159
38Aplasia/hypoplasia of the uterus (HP:0008684)2.79777616
39Abnormal number of erythroid precursors (HP:0012131)2.75902207
40Bicornuate uterus (HP:0000813)2.75017991
41Optic neuritis (HP:0100653)2.73600474
42Retrobulbar optic neuritis (HP:0100654)2.73600474
43Myositis (HP:0100614)2.70829563
44Parakeratosis (HP:0001036)2.68642084
45Gonadotropin excess (HP:0000837)2.68107517
46Mesangial abnormality (HP:0001966)2.66882851
47Anorexia (HP:0002039)2.65890045
48Elevated erythrocyte sedimentation rate (HP:0003565)2.65124978
49Abnormality of secondary sexual hair (HP:0009888)2.64694500
50Abnormality of the axillary hair (HP:0100134)2.64694500
51Basal ganglia calcification (HP:0002135)2.62195298
52Preaxial foot polydactyly (HP:0001841)2.58290265
53Pancreatic fibrosis (HP:0100732)2.57741513
54Recurrent bacterial skin infections (HP:0005406)2.56066092
55Decreased electroretinogram (ERG) amplitude (HP:0000654)2.55478063
56Meningitis (HP:0001287)2.52292253
57Stomatitis (HP:0010280)2.51698854
58Chronic obstructive pulmonary disease (HP:0006510)2.47219419
59Obstructive lung disease (HP:0006536)2.47219419
60Spastic paraplegia (HP:0001258)2.45927747
61Abnormality of the left ventricular outflow tract (HP:0011103)2.44832190
62Subaortic stenosis (HP:0001682)2.44832190
63Abnormality of dental color (HP:0011073)2.44748451
64Polydipsia (HP:0001959)2.43423590
65Abnormal drinking behavior (HP:0030082)2.43423590
66Petechiae (HP:0000967)2.40141550
67Absent speech (HP:0001344)2.38024818
68Bicuspid aortic valve (HP:0001647)2.37588410
693-Methylglutaconic aciduria (HP:0003535)2.37159896
70Gangrene (HP:0100758)2.36558858
71Encephalitis (HP:0002383)2.35892815
72Aplasia/Hypoplasia of the sacrum (HP:0008517)2.35149936
73Spastic tetraparesis (HP:0001285)2.35088513
74Renal Fanconi syndrome (HP:0001994)2.34071571
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33571598
76Chromosomal breakage induced by crosslinking agents (HP:0003221)2.32999334
77Acne (HP:0001061)2.32482946
78Orchitis (HP:0100796)2.31482053
79Aplasia/Hypoplasia of the tibia (HP:0005772)2.31249901
80Chronic mucocutaneous candidiasis (HP:0002728)2.30285828
81Recurrent cutaneous fungal infections (HP:0011370)2.30285828
82Reticulocytopenia (HP:0001896)2.30246500
83Keratitis (HP:0000491)2.30040468
84Exertional dyspnea (HP:0002875)2.29942464
85Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.29604024
86Eczematoid dermatitis (HP:0000976)2.29107788
87Breast carcinoma (HP:0003002)2.28011400
88Craniofacial hyperostosis (HP:0004493)2.27499709
89Pulmonary embolism (HP:0002204)2.26236090
90Hyperaldosteronism (HP:0000859)2.24293837
91White forelock (HP:0002211)2.23167068
92Aplasia/Hypoplasia of the fovea (HP:0008060)2.22733361
93Hypoplasia of the fovea (HP:0007750)2.22733361
94Vertigo (HP:0002321)2.22241660
95Attenuation of retinal blood vessels (HP:0007843)2.21207207
96Patchy hypopigmentation of hair (HP:0011365)2.21148931
97Prolonged bleeding time (HP:0003010)2.20627983
98Frequent falls (HP:0002359)2.19552359
99Anencephaly (HP:0002323)2.19367806
100Clumsiness (HP:0002312)2.19262077
101Abnormality of serine family amino acid metabolism (HP:0010894)2.18863564
102Abnormality of glycine metabolism (HP:0010895)2.18863564
103Arterial thrombosis (HP:0004420)2.17932653
104Abnormality of renin-angiotensin system (HP:0000847)2.17536129
105Anomalous pulmonary venous return (HP:0010772)2.17109760
106Amelogenesis imperfecta (HP:0000705)2.16676715
107Paraplegia (HP:0010550)2.16625121
108Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.16554489
109Germ cell neoplasia (HP:0100728)2.15935471
110Increased hepatocellular lipid droplets (HP:0006565)2.14647660
111Constricted visual fields (HP:0001133)2.13516875
112Pancreatic cysts (HP:0001737)2.12703910
113Loss of speech (HP:0002371)2.12332754
114Increased neuronal autofluorescent lipopigment (HP:0002074)2.11967518
115Agammaglobulinemia (HP:0004432)2.09541393
116Abnormality of proline metabolism (HP:0010907)2.09065716
117Hydroxyprolinuria (HP:0003080)2.09065716
118Chronic hepatic failure (HP:0100626)2.07796491
119Delayed puberty (HP:0000823)2.06997501
120Clubbing of toes (HP:0100760)2.06566035
121Dry hair (HP:0011359)2.06239611
122Abnormality of the prostate (HP:0008775)2.06042313
123Cheilitis (HP:0100825)2.05391377
124Atrioventricular block (HP:0001678)2.04520639
125Stage 5 chronic kidney disease (HP:0003774)2.04088401
126Optic nerve hypoplasia (HP:0000609)2.03446995
127Recurrent skin infections (HP:0001581)2.02865027
128Chromsome breakage (HP:0040012)2.01360765
129Ileus (HP:0002595)2.00920780
130CNS demyelination (HP:0007305)2.00406622
131Abnormal ciliary motility (HP:0012262)1.99752827
132Gonadal dysgenesis (HP:0000133)1.98745107
133Opisthotonus (HP:0002179)1.98588610
134Severe visual impairment (HP:0001141)1.98389051
135Abnormality of the columella (HP:0009929)1.97906376
136Hyperactive renin-angiotensin system (HP:0000841)1.97494568
137Abnormal rod and cone electroretinograms (HP:0008323)1.97160642
138Abnormality of the preputium (HP:0100587)1.97042460
139Glomerulopathy (HP:0100820)1.95989690
140Decreased central vision (HP:0007663)1.95728495
141Hyperkalemia (HP:0002153)1.94702507
142Aplastic anemia (HP:0001915)1.94160626
143Metaphyseal dysplasia (HP:0100255)1.94043277
144Flat occiput (HP:0005469)1.93712155
145Delayed closure of the anterior fontanelle (HP:0001476)1.93427881
146Abnormality of magnesium homeostasis (HP:0004921)1.93143030
147Vasculitis (HP:0002633)1.91357946
148Abnormality of the dental pulp (HP:0006479)1.89978216
149Aplasia/Hypoplasia of the uvula (HP:0010293)1.89970790
150Glucose intolerance (HP:0000833)1.89848207
151Pulmonary infiltrates (HP:0002113)1.89740924
152Abnormal biliary tract physiology (HP:0012439)1.89078431
153Bile duct proliferation (HP:0001408)1.89078431
154Pallor (HP:0000980)1.88499657
155Abnormal respiratory motile cilium morphology (HP:0005938)1.87561898
156Abnormal respiratory epithelium morphology (HP:0012253)1.87561898
157Abnormality of the pulmonary veins (HP:0011718)1.87440728
158Tapered finger (HP:0001182)1.87034194
159Aplasia/Hypoplasia of the spleen (HP:0010451)1.85894169
160Abnormality of glutamine family amino acid metabolism (HP:0010902)1.85596136
161Ureteral stenosis (HP:0000071)1.85261420
162Absent/shortened dynein arms (HP:0200106)1.85186051
163Dynein arm defect of respiratory motile cilia (HP:0012255)1.85186051
164Recurrent fungal infections (HP:0002841)1.84640480
165Abnormal glucose tolerance (HP:0001952)1.83110227
166Abnormality of renal resorption (HP:0011038)1.83088262
167Hemoptysis (HP:0002105)1.82130329
168Febrile seizures (HP:0002373)1.80668984
169Abnormality of macrophages (HP:0004311)1.79694340
170Prostate neoplasm (HP:0100787)1.79626183
171Panhypogammaglobulinemia (HP:0003139)1.78907559
172Abnormality of the fovea (HP:0000493)1.78824647
173Abnormal respiratory motile cilium physiology (HP:0012261)1.78304442
174Sex reversal (HP:0012245)1.78225808
175Abnormal sex determination (HP:0012244)1.78225808
176Recurrent pneumonia (HP:0006532)1.78150588
177Male pseudohermaphroditism (HP:0000037)1.77734564
178Septo-optic dysplasia (HP:0100842)1.77611581
179Absent thumb (HP:0009777)1.74114711
180Congenital sensorineural hearing impairment (HP:0008527)1.73949862
181Albinism (HP:0001022)1.73599753
182Abnormal delayed hypersensitivity skin test (HP:0002963)1.73001154
183Vacuolated lymphocytes (HP:0001922)1.72941446
184Medial flaring of the eyebrow (HP:0010747)1.70319208
185Median cleft lip (HP:0000161)1.68860772
186Abnormality of the ileum (HP:0001549)1.68460472
187Abnormality of DNA repair (HP:0003254)1.67790046
188Mitochondrial inheritance (HP:0001427)1.66476298
189Recurrent gram-negative bacterial infections (HP:0005420)1.65436676

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.27622337
2WNK37.53848210
3TNIK5.11763200
4MUSK3.68773621
5EEF2K3.26793756
6CASK3.23770742
7MKNK22.71134512
8NME22.66472462
9IRAK42.58047899
10MAPKAPK32.45674407
11MAP3K142.36743406
12IRAK32.34981449
13TXK2.06037525
14CDK121.99768313
15BMPR21.99043614
16STK161.98053758
17NLK1.97585677
18YES11.97118328
19PIM21.92901376
20TEC1.88710833
21MAP2K71.83313635
22FER1.82527899
23RIPK41.81610454
24MKNK11.78943458
25BLK1.73604283
26SRPK11.70353701
27ADRBK21.59856995
28MAPK131.58149884
29PRPF4B1.52736294
30SIK31.48621398
31BMPR1B1.47405030
32EIF2AK21.41560260
33EIF2AK31.40714578
34MAP3K121.38771144
35CLK11.37867797
36IKBKB1.37203987
37KIT1.34381287
38PRKCZ1.25139616
39PINK11.23879054
40IRAK21.23517926
41MAP3K131.21953546
42IKBKE1.20427195
43VRK11.19906231
44ACVR1B1.13858338
45CDK31.12955276
46CSK1.12121481
47GRK71.11978960
48IRAK11.11752450
49INSRR1.06659524
50BTK1.03554588
51STK390.97942038
52OXSR10.96690097
53ZAK0.95658957
54TGFBR20.92445780
55TIE10.90389895
56TAOK20.89287585
57MAPKAPK50.86592358
58CHEK20.85366170
59ERBB30.85170909
60SYK0.83031864
61MST40.81706631
62GRK50.81223695
63GRK10.81185909
64MAPK150.80856413
65CSF1R0.80490017
66PLK40.79732380
67CDK80.79205366
68ARAF0.79142725
69LYN0.77018627
70TBK10.75592510
71PIK3CA0.75363603
72TNK20.73101915
73MATK0.71832516
74CAMK10.71829407
75STK240.68456628
76BCKDK0.66552851
77RPS6KC10.65608014
78RPS6KL10.65608014
79RPS6KB20.65204577
80IGF1R0.62687560
81RPS6KA60.62535399
82CAMKK20.62461163
83DYRK30.62375540
84MAP2K60.61276370
85FES0.60800421
86MAP3K60.59932662
87PIM10.59649498
88NEK10.58560339
89JAK30.58235705
90MAPK40.58200650
91STK38L0.57798188
92WNK40.57430690
93PRKCH0.56633930
94HIPK20.56139880
95TGFBR10.55461323
96FLT30.55306472
97PIK3CG0.54725747
98BRAF0.53121332
99TAOK30.52963435
100CDK190.52767075
101MAPK70.50823299
102PRKG20.50730678
103CHUK0.50622398
104AKT30.48486852
105MOS0.46938407
106PRKG10.46808386
107JAK10.46605032
108PRKD20.45731806
109TTK0.44959979
110MAP3K70.44563968
111PRKD30.44125948
112RPS6KA50.43816028
113MAP2K10.43283267
114MAPK110.42872858
115LCK0.41699271
116PRKCB0.41038732
117PRKCA0.41009887
118NTRK30.40886816
119CDK70.39864258
120ADRBK10.39501752
121WEE10.38697331
122RPS6KA40.38580865
123MAP4K10.38232200
124PDK10.37283621
125SGK20.36641539
126ZAP700.35877664
127NEK60.35828457
128TRPM70.34596961
129CCNB10.34371739
130MAPK120.33814577
131TLK10.32696000
132DAPK10.31579747
133MET0.29706069
134TRIB30.29357917
135LIMK10.28423420
136STK30.24688612
137GSK3A0.24530949
138CAMK1D0.24002496
139PRKACA0.23678492
140RPS6KA30.21878333
141CAMK2A0.21168100
142RPS6KA20.21025305
143MAPK100.16825717
144NEK20.16331959
145INSR0.16261920
146GSK3B0.16003701
147CSNK1A10.15912416
148PRKAA20.14580401
149PRKCQ0.14496619
150MAPK140.12853420
151MAPK10.12689784
152CDK60.12640631
153SIK10.12418699
154MAP3K80.12088263
155PRKCG0.10848880
156STK380.09782613
157RPS6KB10.09141147
158STK100.08938614

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004503.85452389
2Ribosome_Homo sapiens_hsa030103.37787145
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.28567484
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.82669276
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53581784
6Histidine metabolism_Homo sapiens_hsa003402.52447210
7Butanoate metabolism_Homo sapiens_hsa006502.43371125
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.18012714
9Homologous recombination_Homo sapiens_hsa034402.17309454
10Graft-versus-host disease_Homo sapiens_hsa053322.14370757
11Propanoate metabolism_Homo sapiens_hsa006402.13926035
12Allograft rejection_Homo sapiens_hsa053302.12296883
13Protein export_Homo sapiens_hsa030602.10321167
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.08659366
15DNA replication_Homo sapiens_hsa030301.94791685
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.88705631
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.86075756
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.77161828
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.77017218
20Fanconi anemia pathway_Homo sapiens_hsa034601.76332677
21Salivary secretion_Homo sapiens_hsa049701.70154782
22Glycerolipid metabolism_Homo sapiens_hsa005611.68237512
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.65333502
24Fat digestion and absorption_Homo sapiens_hsa049751.65268785
25Calcium signaling pathway_Homo sapiens_hsa040201.63103895
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57291660
27Primary immunodeficiency_Homo sapiens_hsa053401.57221616
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.57045249
29Leishmaniasis_Homo sapiens_hsa051401.56262159
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.53558248
31Other glycan degradation_Homo sapiens_hsa005111.49961611
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47881433
33RNA polymerase_Homo sapiens_hsa030201.47520379
34Tryptophan metabolism_Homo sapiens_hsa003801.47358530
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46857889
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46430258
37Rheumatoid arthritis_Homo sapiens_hsa053231.45082507
38Pyrimidine metabolism_Homo sapiens_hsa002401.44118270
39Arachidonic acid metabolism_Homo sapiens_hsa005901.44044125
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.42666279
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41965820
42Hematopoietic cell lineage_Homo sapiens_hsa046401.41474215
43Oxidative phosphorylation_Homo sapiens_hsa001901.40216504
44Asthma_Homo sapiens_hsa053101.39523026
45Autoimmune thyroid disease_Homo sapiens_hsa053201.39430210
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39037678
47Measles_Homo sapiens_hsa051621.38471593
48Base excision repair_Homo sapiens_hsa034101.37302615
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29314319
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28874692
51Non-homologous end-joining_Homo sapiens_hsa034501.26856843
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26580606
53Dorso-ventral axis formation_Homo sapiens_hsa043201.26386020
54Type I diabetes mellitus_Homo sapiens_hsa049401.23985026
55Mismatch repair_Homo sapiens_hsa034301.23529013
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.23133045
57Phototransduction_Homo sapiens_hsa047441.21255162
58Glutathione metabolism_Homo sapiens_hsa004801.20905347
59Fatty acid degradation_Homo sapiens_hsa000711.17707951
60Pertussis_Homo sapiens_hsa051331.15673768
61Vitamin digestion and absorption_Homo sapiens_hsa049771.10888056
62ABC transporters_Homo sapiens_hsa020101.10378956
63Sphingolipid metabolism_Homo sapiens_hsa006001.09263393
64Fatty acid metabolism_Homo sapiens_hsa012121.09186940
65cAMP signaling pathway_Homo sapiens_hsa040241.09153348
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.07362847
67Proteasome_Homo sapiens_hsa030501.07239729
68Ovarian steroidogenesis_Homo sapiens_hsa049131.04501013
69Nucleotide excision repair_Homo sapiens_hsa034201.03495419
70Herpes simplex infection_Homo sapiens_hsa051681.03318333
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03287487
72Basal transcription factors_Homo sapiens_hsa030221.03246276
73Purine metabolism_Homo sapiens_hsa002301.02443908
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.97814726
75African trypanosomiasis_Homo sapiens_hsa051430.94988671
76Malaria_Homo sapiens_hsa051440.94751772
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92438547
78TNF signaling pathway_Homo sapiens_hsa046680.91496957
79Tuberculosis_Homo sapiens_hsa051520.90761708
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90514936
81Lysine degradation_Homo sapiens_hsa003100.89597583
82Oxytocin signaling pathway_Homo sapiens_hsa049210.88609152
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88000755
84Parkinsons disease_Homo sapiens_hsa050120.85882931
85Influenza A_Homo sapiens_hsa051640.85222346
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84989249
87Fatty acid biosynthesis_Homo sapiens_hsa000610.83822380
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.83160381
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.80719571
90Peroxisome_Homo sapiens_hsa041460.80476960
91Legionellosis_Homo sapiens_hsa051340.79177014
92Huntingtons disease_Homo sapiens_hsa050160.78506565
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78336549
94Osteoclast differentiation_Homo sapiens_hsa043800.78151510
95Regulation of autophagy_Homo sapiens_hsa041400.78118954
96N-Glycan biosynthesis_Homo sapiens_hsa005100.77021299
97Salmonella infection_Homo sapiens_hsa051320.75662427
98Spliceosome_Homo sapiens_hsa030400.75538062
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73317565
100Cholinergic synapse_Homo sapiens_hsa047250.70803799
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70364533
102Alzheimers disease_Homo sapiens_hsa050100.70109260
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69056929
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64648581
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64223084
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.62745191
107p53 signaling pathway_Homo sapiens_hsa041150.62312608
108Serotonergic synapse_Homo sapiens_hsa047260.61643636
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61081493
110Phagosome_Homo sapiens_hsa041450.60929952
111Hepatitis B_Homo sapiens_hsa051610.60370287
112Thyroid cancer_Homo sapiens_hsa052160.60287077
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59259260
114RNA degradation_Homo sapiens_hsa030180.58985080
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58665720
116Taste transduction_Homo sapiens_hsa047420.58183886
117Nicotine addiction_Homo sapiens_hsa050330.57881813
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57259446
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55565279
120Ether lipid metabolism_Homo sapiens_hsa005650.55268467
121RNA transport_Homo sapiens_hsa030130.53248218
122Acute myeloid leukemia_Homo sapiens_hsa052210.53214857
123Chemokine signaling pathway_Homo sapiens_hsa040620.52616231
124Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52379672
125Apoptosis_Homo sapiens_hsa042100.51609344
126One carbon pool by folate_Homo sapiens_hsa006700.49900601
127Olfactory transduction_Homo sapiens_hsa047400.49340708
128B cell receptor signaling pathway_Homo sapiens_hsa046620.49251840
129Metabolic pathways_Homo sapiens_hsa011000.49131292
130Gastric acid secretion_Homo sapiens_hsa049710.46952832
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45451405
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45125134
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45093645
134Shigellosis_Homo sapiens_hsa051310.45054686
135Antigen processing and presentation_Homo sapiens_hsa046120.42062641
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41646004
137Staphylococcus aureus infection_Homo sapiens_hsa051500.41260683
138Nitrogen metabolism_Homo sapiens_hsa009100.41061034
139Folate biosynthesis_Homo sapiens_hsa007900.40797125
140Hepatitis C_Homo sapiens_hsa051600.37357996
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36594989
142Morphine addiction_Homo sapiens_hsa050320.36410079
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34536098
144PPAR signaling pathway_Homo sapiens_hsa033200.34288346
145Pancreatic secretion_Homo sapiens_hsa049720.34281150
146Linoleic acid metabolism_Homo sapiens_hsa005910.34263472
147Toxoplasmosis_Homo sapiens_hsa051450.34200267
148Steroid biosynthesis_Homo sapiens_hsa001000.33457399
149Collecting duct acid secretion_Homo sapiens_hsa049660.33263127
150Chemical carcinogenesis_Homo sapiens_hsa052040.32809155
151Platelet activation_Homo sapiens_hsa046110.30346455
152Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27504828
153Retinol metabolism_Homo sapiens_hsa008300.27397162
154Epstein-Barr virus infection_Homo sapiens_hsa051690.27168890
155Pyruvate metabolism_Homo sapiens_hsa006200.25003072
156Arginine biosynthesis_Homo sapiens_hsa002200.19988638
157Protein digestion and absorption_Homo sapiens_hsa049740.19345843
158Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18476433
159Sulfur relay system_Homo sapiens_hsa041220.15766519
160GABAergic synapse_Homo sapiens_hsa047270.15710512
161Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13907562
162Leukocyte transendothelial migration_Homo sapiens_hsa046700.10662532
163Arginine and proline metabolism_Homo sapiens_hsa003300.10390896

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