ASF1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.00092977
2DNA double-strand break processing (GO:0000729)4.90997996
3DNA strand elongation involved in DNA replication (GO:0006271)4.78590065
4telomere maintenance via semi-conservative replication (GO:0032201)4.71102736
5DNA replication initiation (GO:0006270)4.55990068
6DNA strand elongation (GO:0022616)4.55480533
7CENP-A containing nucleosome assembly (GO:0034080)4.47094226
8chromatin remodeling at centromere (GO:0031055)4.40762133
9viral transcription (GO:0019083)4.38861247
10translational termination (GO:0006415)4.34432507
11ribosomal small subunit assembly (GO:0000028)4.31068393
12DNA replication checkpoint (GO:0000076)4.26340067
13maturation of SSU-rRNA (GO:0030490)4.25917369
14telomere maintenance via recombination (GO:0000722)4.25531899
15cullin deneddylation (GO:0010388)4.22841800
16kinetochore organization (GO:0051383)4.17868236
17ribosomal small subunit biogenesis (GO:0042274)4.05512825
18regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.03104392
19regulation of mitotic spindle checkpoint (GO:1903504)4.03104392
20protein deneddylation (GO:0000338)4.02197000
21mitotic recombination (GO:0006312)3.99575439
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.96238187
23* DNA replication-independent nucleosome organization (GO:0034724)3.93459068
24* DNA replication-independent nucleosome assembly (GO:0006336)3.93459068
25kinetochore assembly (GO:0051382)3.90169977
26DNA unwinding involved in DNA replication (GO:0006268)3.88785676
27translational elongation (GO:0006414)3.86159802
28mitotic metaphase plate congression (GO:0007080)3.81368519
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.80388167
30cotranslational protein targeting to membrane (GO:0006613)3.72385435
31translational initiation (GO:0006413)3.72192944
32protein targeting to ER (GO:0045047)3.69762112
33negative regulation of DNA-dependent DNA replication (GO:2000104)3.65852946
34telomere maintenance via telomere lengthening (GO:0010833)3.65167791
35DNA catabolic process, exonucleolytic (GO:0000738)3.64361137
36histone exchange (GO:0043486)3.63775470
37regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.63251995
38protein neddylation (GO:0045116)3.61552564
39proteasome assembly (GO:0043248)3.61344095
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.58615590
41nucleotide-excision repair, DNA gap filling (GO:0006297)3.56335270
42ribosomal large subunit biogenesis (GO:0042273)3.54999054
43meiotic chromosome segregation (GO:0045132)3.52713882
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.52049052
45metaphase plate congression (GO:0051310)3.49451735
46protein localization to endoplasmic reticulum (GO:0070972)3.49410494
47postreplication repair (GO:0006301)3.47624601
48RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.46919906
49establishment of integrated proviral latency (GO:0075713)3.46821812
50synapsis (GO:0007129)3.43267513
51ribosome assembly (GO:0042255)3.43149251
52mitotic nuclear envelope disassembly (GO:0007077)3.42461057
53protein localization to kinetochore (GO:0034501)3.40353359
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.39339357
55viral life cycle (GO:0019058)3.38873061
56cellular protein complex disassembly (GO:0043624)3.36231259
57replication fork processing (GO:0031297)3.35278834
58ribonucleoprotein complex biogenesis (GO:0022613)3.33453810
59centriole replication (GO:0007099)3.31902566
60formation of translation preinitiation complex (GO:0001731)3.28797603
61protein localization to chromosome, centromeric region (GO:0071459)3.28553523
62nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.27234791
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.26952052
64regulation of mitotic metaphase/anaphase transition (GO:0030071)3.26952052
65spliceosomal snRNP assembly (GO:0000387)3.25786070
66nucleobase biosynthetic process (GO:0046112)3.25064930
67mitotic chromosome condensation (GO:0007076)3.23389383
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20629860
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.20449538
70attachment of spindle microtubules to kinetochore (GO:0008608)3.19338264
71* DNA replication-dependent nucleosome assembly (GO:0006335)3.18688256
72* DNA replication-dependent nucleosome organization (GO:0034723)3.18688256
73DNA damage response, detection of DNA damage (GO:0042769)3.18554969
74rRNA processing (GO:0006364)3.18101411
75regulation of meiosis I (GO:0060631)3.17679969
76rRNA modification (GO:0000154)3.17510424
77regulation of mitotic sister chromatid separation (GO:0010965)3.16933321
78regulation of mitotic sister chromatid segregation (GO:0033047)3.16933321
79regulation of sister chromatid segregation (GO:0033045)3.16933321
80DNA ligation (GO:0006266)3.15391466
81transcription-coupled nucleotide-excision repair (GO:0006283)3.14425175
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14388894
83deoxyribonucleotide biosynthetic process (GO:0009263)3.13986787
84positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.13608324
85nuclear envelope disassembly (GO:0051081)3.13349832
86membrane disassembly (GO:0030397)3.13349832
87establishment of chromosome localization (GO:0051303)3.11286952
88translation (GO:0006412)3.09770682
89pseudouridine synthesis (GO:0001522)3.09297551
90purine nucleobase biosynthetic process (GO:0009113)3.06936236
91negative regulation of DNA recombination (GO:0045910)3.06206151
92rRNA metabolic process (GO:0016072)3.06186440
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.06096871
94negative regulation of mitotic sister chromatid separation (GO:2000816)3.06060162
95negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06060162
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06060162
97negative regulation of sister chromatid segregation (GO:0033046)3.06060162
98regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05202269
99nuclear-transcribed mRNA catabolic process (GO:0000956)3.03688175
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.03252451
101signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.03252451
102signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.03252451
103negative regulation of chromosome segregation (GO:0051985)3.03123041
104DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.02754169
105negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02550318
106spliceosomal complex assembly (GO:0000245)3.02386479
107regulation of cellular amino acid metabolic process (GO:0006521)3.01946476
108spindle checkpoint (GO:0031577)3.01946221
109ribosome biogenesis (GO:0042254)3.00903818
110chaperone-mediated protein transport (GO:0072321)3.00489703
111spindle assembly checkpoint (GO:0071173)3.00173908
112protein complex disassembly (GO:0043241)3.00083180
113folic acid-containing compound biosynthetic process (GO:0009396)2.99772773
114positive regulation of ligase activity (GO:0051351)2.98643036
115somatic hypermutation of immunoglobulin genes (GO:0016446)2.98642171
116somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98642171
117histone mRNA metabolic process (GO:0008334)2.98534722
118mitotic spindle assembly checkpoint (GO:0007094)2.98218109
119intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.98015434
120signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.98015434
121regulation of double-strand break repair via homologous recombination (GO:0010569)2.97642594
122non-recombinational repair (GO:0000726)2.97507368
123double-strand break repair via nonhomologous end joining (GO:0006303)2.97507368
124regulation of helicase activity (GO:0051095)2.96296875
125* chromatin assembly or disassembly (GO:0006333)2.94742720
126piRNA metabolic process (GO:0034587)2.94418193
127pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.93862342
128pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.92633427
129cell cycle G1/S phase transition (GO:0044843)2.92521709
130G1/S transition of mitotic cell cycle (GO:0000082)2.92521709
131signal transduction involved in cell cycle checkpoint (GO:0072395)2.92375295
132negative regulation of ligase activity (GO:0051352)2.92025956
133negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92025956
134tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.91258863
135RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.91258863
136regulation of chromosome segregation (GO:0051983)2.91103155
137establishment of protein localization to mitochondrial membrane (GO:0090151)2.90952903
138signal transduction involved in DNA integrity checkpoint (GO:0072401)2.90811575
139signal transduction involved in DNA damage checkpoint (GO:0072422)2.90811575
140mRNA catabolic process (GO:0006402)2.89855555
141regulation of ubiquitin-protein transferase activity (GO:0051438)2.89758514
142mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.89617324
143regulation of spindle organization (GO:0090224)2.88660816
144negative regulation of RNA splicing (GO:0033119)2.88308427
145regulation of centriole replication (GO:0046599)2.87830438
146maturation of 5.8S rRNA (GO:0000460)2.87231758
147maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.86813527
148mitotic spindle checkpoint (GO:0071174)2.85709852
149protein K6-linked ubiquitination (GO:0085020)2.85315522

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.31683161
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.37230062
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82258192
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.79768936
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.74592440
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.44516555
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.30062222
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.28719327
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.16396741
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.93090353
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.92655544
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84631161
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82253628
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79220382
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.75198541
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.74147898
17VDR_23849224_ChIP-Seq_CD4+_Human2.50150570
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49707071
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.48233982
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42502964
21XRN2_22483619_ChIP-Seq_HELA_Human2.37155462
22AR_21909140_ChIP-Seq_LNCAP_Human2.34537250
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.31158828
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.27810760
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21282520
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13453021
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11307302
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07415733
29EWS_26573619_Chip-Seq_HEK293_Human2.06739728
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04710727
31E2F1_21310950_ChIP-Seq_MCF-7_Human2.03200334
32FUS_26573619_Chip-Seq_HEK293_Human2.02504027
33FOXP3_21729870_ChIP-Seq_TREG_Human2.02320249
34DCP1A_22483619_ChIP-Seq_HELA_Human2.01535824
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99957204
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98513090
37GABP_19822575_ChIP-Seq_HepG2_Human1.97333260
38ZNF274_21170338_ChIP-Seq_K562_Hela1.94418880
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94209023
40TTF2_22483619_ChIP-Seq_HELA_Human1.89798750
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87980875
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83889421
43VDR_22108803_ChIP-Seq_LS180_Human1.83210759
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82509735
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.82219204
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80550675
47ELK1_19687146_ChIP-ChIP_HELA_Human1.80333470
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.78254484
49* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77270029
50IGF1R_20145208_ChIP-Seq_DFB_Human1.76947722
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71382400
52* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69720140
53TAF15_26573619_Chip-Seq_HEK293_Human1.67416872
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59937923
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55990242
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55731277
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.53145785
58CIITA_25753668_ChIP-Seq_RAJI_Human1.53031920
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52782031
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49837402
61* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46549519
62* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41476617
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.41474568
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41080560
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39874561
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38822838
67P300_19829295_ChIP-Seq_ESCs_Human1.38782123
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38375916
69KDM5A_27292631_Chip-Seq_BREAST_Human1.38002963
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35696721
71EZH2_22144423_ChIP-Seq_EOC_Human1.34783387
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32679252
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30715021
74CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.27067898
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27023899
76MYC_18940864_ChIP-ChIP_HL60_Human1.27019412
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26431506
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24795928
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23596384
80MYC_22102868_ChIP-Seq_BL_Human1.23452446
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21450232
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.21393937
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17077973
84NANOG_16153702_ChIP-ChIP_HESCs_Human1.14960729
85IRF1_19129219_ChIP-ChIP_H3396_Human1.14685691
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.12318803
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10060735
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09562163
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09379064
90* EZH2_27294783_Chip-Seq_NPCs_Mouse1.08624654
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08072375
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.07172334
93SPI1_23547873_ChIP-Seq_NB4_Human1.05941548
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05368266
95SOX2_16153702_ChIP-ChIP_HESCs_Human1.01822652
96* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01705620
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00572091
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00263619
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00047668
100GBX2_23144817_ChIP-Seq_PC3_Human0.99976012
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99645165
102ELK1_22589737_ChIP-Seq_MCF10A_Human0.99317270
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99040022
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98444613
105TFEB_21752829_ChIP-Seq_HELA_Human0.97992178
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97003327
107CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96812894
108* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96658414
109SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94382888
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94279976
111TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94275938
112CBP_20019798_ChIP-Seq_JUKART_Human0.93812944
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93812944
114CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93700642
115SALL4_22934838_ChIP-ChIP_CD34+_Human0.92913646
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92286732
117TP53_22573176_ChIP-Seq_HFKS_Human0.91647073
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91620331
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91419558
120NFE2_27457419_Chip-Seq_LIVER_Mouse0.91161212
121VDR_21846776_ChIP-Seq_THP-1_Human0.90515374
122ER_23166858_ChIP-Seq_MCF-7_Human0.90216083
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89886508
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88669794
125NANOG_19829295_ChIP-Seq_ESCs_Human0.88232570
126SOX2_19829295_ChIP-Seq_ESCs_Human0.88232570
127SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87603991
128PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86679331
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84437755
130CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84213933
131IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.83000993
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81572516
133SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.79518778
134* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74849444
135* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73973032
136NANOG_21062744_ChIP-ChIP_HESCs_Human0.71619330
137STAT3_1855785_ChIP-Seq_MESCs_Mouse0.71161934
138* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71137524
139FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.70676773
140SOX17_20123909_ChIP-Seq_XEN_Mouse0.70486654
141CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.69682580
142TBX5_21415370_ChIP-Seq_HL-1_Mouse0.67997533

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.49837102
2MP0010094_abnormal_chromosome_stability4.60468649
3MP0004957_abnormal_blastocyst_morpholog4.33831694
4MP0003111_abnormal_nucleus_morphology4.08104979
5MP0003077_abnormal_cell_cycle3.98820697
6MP0008057_abnormal_DNA_replication3.40139263
7MP0008058_abnormal_DNA_repair3.11693689
8MP0008007_abnormal_cellular_replicative2.89375839
9MP0008789_abnormal_olfactory_epithelium2.83583231
10MP0008932_abnormal_embryonic_tissue2.80626397
11MP0009697_abnormal_copulation2.39401671
12MP0005394_taste/olfaction_phenotype2.30659863
13MP0005499_abnormal_olfactory_system2.30659863
14MP0002396_abnormal_hematopoietic_system2.29089452
15MP0008877_abnormal_DNA_methylation2.26737501
16MP0003718_maternal_effect2.16790103
17MP0000490_abnormal_crypts_of2.14248323
18MP0000350_abnormal_cell_proliferation2.09268262
19MP0003123_paternal_imprinting2.09004574
20MP0001730_embryonic_growth_arrest1.93525887
21MP0003941_abnormal_skin_development1.84575946
22MP0003786_premature_aging1.73198947
23MP0002102_abnormal_ear_morphology1.68121926
24MP0000372_irregular_coat_pigmentation1.67835239
25MP0006054_spinal_hemorrhage1.64842928
26MP0001984_abnormal_olfaction1.63604458
27MP0009333_abnormal_splenocyte_physiolog1.61655435
28MP0002234_abnormal_pharynx_morphology1.60625664
29MP0006072_abnormal_retinal_apoptosis1.60524190
30MP0001697_abnormal_embryo_size1.59907217
31MP0003656_abnormal_erythrocyte_physiolo1.55811015
32MP0000313_abnormal_cell_death1.52590232
33MP0003315_abnormal_perineum_morphology1.51287489
34MP0010307_abnormal_tumor_latency1.50151534
35MP0003787_abnormal_imprinting1.50010013
36MP0003763_abnormal_thymus_physiology1.45990262
37MP0002210_abnormal_sex_determination1.45978952
38MP0003567_abnormal_fetal_cardiomyocyte1.45547293
39MP0002019_abnormal_tumor_incidence1.45076594
40MP0002085_abnormal_embryonic_tissue1.43405379
41MP0005395_other_phenotype1.43010991
42MP0006292_abnormal_olfactory_placode1.42202865
43MP0008995_early_reproductive_senescence1.42065788
44MP0004808_abnormal_hematopoietic_stem1.41756398
45MP0002080_prenatal_lethality1.41456543
46MP0005380_embryogenesis_phenotype1.39621669
47MP0001672_abnormal_embryogenesis/_devel1.39621669
48MP0001145_abnormal_male_reproductive1.30193222
49MP0002751_abnormal_autonomic_nervous1.29504726
50MP0003186_abnormal_redox_activity1.29359932
51MP0006035_abnormal_mitochondrial_morpho1.28601614
52MP0004147_increased_porphyrin_level1.28141901
53MP0009379_abnormal_foot_pigmentation1.27799967
54MP0001545_abnormal_hematopoietic_system1.27599339
55MP0005397_hematopoietic_system_phenotyp1.27599339
56MP0001929_abnormal_gametogenesis1.27042823
57MP0003880_abnormal_central_pattern1.25420943
58MP0005253_abnormal_eye_physiology1.23722979
59MP0000703_abnormal_thymus_morphology1.23554527
60MP0003984_embryonic_growth_retardation1.22157899
61MP0002398_abnormal_bone_marrow1.21889928
62MP0003806_abnormal_nucleotide_metabolis1.21878741
63MP0000653_abnormal_sex_gland1.20587158
64MP0002084_abnormal_developmental_patter1.20305786
65MP0002088_abnormal_embryonic_growth/wei1.18503556
66MP0002736_abnormal_nociception_after1.17532225
67MP0001188_hyperpigmentation1.13782571
68MP0001293_anophthalmia1.13709990
69MP0002132_abnormal_respiratory_system1.12861723
70MP0004215_abnormal_myocardial_fiber1.10015469
71MP0000631_abnormal_neuroendocrine_gland1.09080945
72MP0002722_abnormal_immune_system1.08654958
73MP0002233_abnormal_nose_morphology1.07632651
74MP0003121_genomic_imprinting1.07462296
75MP0003937_abnormal_limbs/digits/tail_de1.05816941
76MP0000689_abnormal_spleen_morphology1.05380074
77MP0001119_abnormal_female_reproductive1.05363661
78MP0002086_abnormal_extraembryonic_tissu1.05028499
79MP0001764_abnormal_homeostasis1.04576974
80MP0010030_abnormal_orbit_morphology1.04426244
81MP0010352_gastrointestinal_tract_polyps1.03865383
82MP0003119_abnormal_digestive_system1.03124197
83MP0002429_abnormal_blood_cell0.98762223
84MP0000537_abnormal_urethra_morphology0.96444041
85MP0000647_abnormal_sebaceous_gland0.94813760
86MP0004197_abnormal_fetal_growth/weight/0.90232190
87MP0005646_abnormal_pituitary_gland0.89896587
88MP0005551_abnormal_eye_electrophysiolog0.89605199
89MP0002938_white_spotting0.89341497
90MP0003890_abnormal_embryonic-extraembry0.88780778
91MP0005671_abnormal_response_to0.87924168
92MP0000716_abnormal_immune_system0.86974193
93MP0000427_abnormal_hair_cycle0.86852683
94MP0005645_abnormal_hypothalamus_physiol0.86655726
95MP0005084_abnormal_gallbladder_morpholo0.85536712
96MP0008260_abnormal_autophagy0.85170471
97MP0005075_abnormal_melanosome_morpholog0.84831740
98MP0002095_abnormal_skin_pigmentation0.84791785
99MP0003136_yellow_coat_color0.84039779
100MP0003646_muscle_fatigue0.82212836
101MP0001529_abnormal_vocalization0.81262127
102MP0005389_reproductive_system_phenotype0.80979080
103MP0005410_abnormal_fertilization0.80615854
104MP0003011_delayed_dark_adaptation0.80095895
105MP0006276_abnormal_autonomic_nervous0.79476459
106MP0005408_hypopigmentation0.79363815
107MP0003195_calcinosis0.79324292
108MP0002653_abnormal_ependyma_morphology0.78149602
109MP0002160_abnormal_reproductive_system0.77468614
110MP0000358_abnormal_cell_content/0.77377260
111MP0000049_abnormal_middle_ear0.77228371
112MP0001915_intracranial_hemorrhage0.76875710
113MP0000858_altered_metastatic_potential0.74032319
114MP0001853_heart_inflammation0.73781083
115MP0003699_abnormal_female_reproductive0.73105045
116MP0006036_abnormal_mitochondrial_physio0.71513856
117MP0001177_atelectasis0.71117496
118MP0005647_abnormal_sex_gland0.70576558
119MP0003221_abnormal_cardiomyocyte_apopto0.70234833
120MP0003137_abnormal_impulse_conducting0.70066554
121MP0002638_abnormal_pupillary_reflex0.69486190
122MP0008872_abnormal_physiological_respon0.69429156
123MP0000477_abnormal_intestine_morphology0.69370335
124MP0000685_abnormal_immune_system0.69030212
125MP0005384_cellular_phenotype0.68739074
126MP0001286_abnormal_eye_development0.66795214
127MP0004142_abnormal_muscle_tone0.66463007
128MP0000516_abnormal_urinary_system0.64833168
129MP0005367_renal/urinary_system_phenotyp0.64833168
130MP0005187_abnormal_penis_morphology0.64498637
131MP0002420_abnormal_adaptive_immunity0.63197112
132MP0002090_abnormal_vision0.63002139
133MP0001919_abnormal_reproductive_system0.62989928
134MP0002249_abnormal_larynx_morphology0.62232649
135MP0001819_abnormal_immune_cell0.61455377
136MP0001800_abnormal_humoral_immune0.60772102
137MP0002405_respiratory_system_inflammati0.60435618
138MP0003698_abnormal_male_reproductive0.60190474
139MP0001835_abnormal_antigen_presentation0.60080344
140MP0005621_abnormal_cell_physiology0.59583650
141MP0002161_abnormal_fertility/fecundity0.59136097
142MP0003938_abnormal_ear_development0.59100993
143MP0002932_abnormal_joint_morphology0.58533906
144MP0002111_abnormal_tail_morphology0.58055876
145MP0002006_tumorigenesis0.57256302

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.38408648
2Abnormal number of erythroid precursors (HP:0012131)5.32692120
3Birth length less than 3rd percentile (HP:0003561)5.20433058
4Reticulocytopenia (HP:0001896)4.46965917
5Aplastic anemia (HP:0001915)3.80279219
6Breast hypoplasia (HP:0003187)3.72850233
7Abnormality of the labia minora (HP:0012880)3.54305023
8Oral leukoplakia (HP:0002745)3.53989664
9Pallor (HP:0000980)3.42609915
10Macrocytic anemia (HP:0001972)3.32896941
11Colon cancer (HP:0003003)3.32733090
12Abnormality of the heme biosynthetic pathway (HP:0010472)3.26471450
13Patellar aplasia (HP:0006443)3.24999887
14Acute encephalopathy (HP:0006846)3.12852825
15Aplasia/Hypoplasia of the patella (HP:0006498)3.11605950
16Chromsome breakage (HP:0040012)2.94719467
17Abnormality of the preputium (HP:0100587)2.91460572
18Abnormality of chromosome stability (HP:0003220)2.86934589
19Medulloblastoma (HP:0002885)2.84103569
20Decreased activity of mitochondrial respiratory chain (HP:0008972)2.83264598
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.83264598
22Progressive macrocephaly (HP:0004481)2.82790223
23Microretrognathia (HP:0000308)2.81352784
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.79930297
25Volvulus (HP:0002580)2.76591860
26Meckel diverticulum (HP:0002245)2.75075326
27Methylmalonic acidemia (HP:0002912)2.74778002
28Carpal bone hypoplasia (HP:0001498)2.71835962
29Short tibia (HP:0005736)2.69206835
30Cerebral hypomyelination (HP:0006808)2.68561183
31Rough bone trabeculation (HP:0100670)2.68029934
32Abnormality of the ileum (HP:0001549)2.67192433
33Selective tooth agenesis (HP:0001592)2.64375369
34Hyperglycinemia (HP:0002154)2.58514962
35Premature graying of hair (HP:0002216)2.55966634
36Oligodactyly (hands) (HP:0001180)2.53647264
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.49011287
38Myelodysplasia (HP:0002863)2.46078856
39Aplasia/Hypoplasia of the tibia (HP:0005772)2.44653888
40Abnormality of the anterior horn cell (HP:0006802)2.44103831
41Degeneration of anterior horn cells (HP:0002398)2.44103831
42Increased hepatocellular lipid droplets (HP:0006565)2.43579239
43Secondary amenorrhea (HP:0000869)2.41202126
44Gonadotropin excess (HP:0000837)2.33616340
45Cerebral edema (HP:0002181)2.32400590
46Pancreatic cysts (HP:0001737)2.32293553
47Neoplasm of the pancreas (HP:0002894)2.29849349
48Poor head control (HP:0002421)2.27354536
49Cellular immunodeficiency (HP:0005374)2.26440279
503-Methylglutaconic aciduria (HP:0003535)2.26026836
51Triphalangeal thumb (HP:0001199)2.25800546
52Absent thumb (HP:0009777)2.25511542
53Bone marrow hypocellularity (HP:0005528)2.25143078
54Duodenal stenosis (HP:0100867)2.25046198
55Small intestinal stenosis (HP:0012848)2.25046198
56Absent radius (HP:0003974)2.24733751
57Lipid accumulation in hepatocytes (HP:0006561)2.20334208
5811 pairs of ribs (HP:0000878)2.19149374
59Abnormality of serum amino acid levels (HP:0003112)2.18556038
60Abnormality of aspartate family amino acid metabolism (HP:0010899)2.18269105
61Premature ovarian failure (HP:0008209)2.18141480
62Hepatic necrosis (HP:0002605)2.16393327
63Methylmalonic aciduria (HP:0012120)2.15941755
64Abnormality of methionine metabolism (HP:0010901)2.15745854
65Supernumerary spleens (HP:0009799)2.15009169
66Median cleft lip (HP:0000161)2.15001603
67Medial flaring of the eyebrow (HP:0010747)2.14584938
68Type I transferrin isoform profile (HP:0003642)2.14245487
69Exertional dyspnea (HP:0002875)2.13777234
70Absent forearm bone (HP:0003953)2.13615892
71Aplasia involving forearm bones (HP:0009822)2.13615892
72Aplasia/Hypoplasia of the thymus (HP:0010515)2.13275380
73Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12902358
74Renal Fanconi syndrome (HP:0001994)2.12334616
75Poikiloderma (HP:0001029)2.11804758
76IgM deficiency (HP:0002850)2.11406898
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10522950
78Abnormality of alanine metabolism (HP:0010916)2.10206883
79Hyperalaninemia (HP:0003348)2.10206883
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10206883
81Nephroblastoma (Wilms tumor) (HP:0002667)2.10001844
82Muscle fiber atrophy (HP:0100295)2.09444538
83Rhabdomyosarcoma (HP:0002859)2.09360867
84Bifid tongue (HP:0010297)2.08060877
85Cleft eyelid (HP:0000625)2.07688843
86Abnormal number of incisors (HP:0011064)2.07561240
87Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06226820
88Abnormal lung lobation (HP:0002101)2.06071357
89Sloping forehead (HP:0000340)2.05799631
90Pancytopenia (HP:0001876)2.05762091
91B lymphocytopenia (HP:0010976)2.05538043
92Abnormality of B cell number (HP:0010975)2.05538043
93Trismus (HP:0000211)2.04433369
94Lactic acidosis (HP:0003128)2.03820810
95Pulmonary fibrosis (HP:0002206)2.03648017
96Embryonal renal neoplasm (HP:0011794)2.03118709
97Pancreatic fibrosis (HP:0100732)2.03113372
98Agnosia (HP:0010524)2.02931954
99Increased serum lactate (HP:0002151)2.02516873
100True hermaphroditism (HP:0010459)2.02498742
101Type 2 muscle fiber atrophy (HP:0003554)2.02365662
102Lymphoma (HP:0002665)2.01240613
103Tracheoesophageal fistula (HP:0002575)2.00908159
104Aplasia/Hypoplasia of the tongue (HP:0010295)1.98618287
105Hypoplastic pelvis (HP:0008839)1.97599357
106Horseshoe kidney (HP:0000085)1.96854935
107Abnormality of glycine metabolism (HP:0010895)1.96416885
108Abnormality of serine family amino acid metabolism (HP:0010894)1.96416885
109Abnormal hair whorl (HP:0010721)1.95693477
110Hepatocellular necrosis (HP:0001404)1.95129631
111Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.95020753
112Facial hemangioma (HP:0000329)1.94901559
113Molar tooth sign on MRI (HP:0002419)1.94435407
114Abnormality of midbrain morphology (HP:0002418)1.94435407
115Thrombocytosis (HP:0001894)1.93110410
116Abnormal spermatogenesis (HP:0008669)1.92894991
117Abnormal trabecular bone morphology (HP:0100671)1.92893592
118Atresia of the external auditory canal (HP:0000413)1.92777356
119Clubbing of toes (HP:0100760)1.91629982
120Abnormality of the duodenum (HP:0002246)1.90746945
121Acute necrotizing encephalopathy (HP:0006965)1.90724642
122Septo-optic dysplasia (HP:0100842)1.90667460
123Overlapping toe (HP:0001845)1.90213351
124Congenital primary aphakia (HP:0007707)1.90175699
125Mitochondrial inheritance (HP:0001427)1.87081029
126Atrophy/Degeneration involving motor neurons (HP:0007373)1.86010223
127Oligodactyly (HP:0012165)1.85112079
128Absent septum pellucidum (HP:0001331)1.85072608
129Multiple enchondromatosis (HP:0005701)1.84544348
130Progressive inability to walk (HP:0002505)1.84413802
131Increased CSF lactate (HP:0002490)1.83122317
132Basal cell carcinoma (HP:0002671)1.82353557
133Abnormal mitochondria in muscle tissue (HP:0008316)1.81654880
134Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80801692
135Short thumb (HP:0009778)1.80575646
136Hypoplasia of the radius (HP:0002984)1.79257048
137Abnormality of the carotid arteries (HP:0005344)1.78138746
138Hyperglycinuria (HP:0003108)1.77959606
139Impulsivity (HP:0100710)1.77663583
140Gait imbalance (HP:0002141)1.77022916
141Abnormality of the septum pellucidum (HP:0007375)1.77014603
142Pendular nystagmus (HP:0012043)1.76149153
143CNS hypomyelination (HP:0003429)1.75355622
144Sparse eyelashes (HP:0000653)1.75080037
145Genital tract atresia (HP:0001827)1.74208047
146Nephrogenic diabetes insipidus (HP:0009806)1.73539837
147Leukodystrophy (HP:0002415)1.72700684
148Abnormal protein glycosylation (HP:0012346)1.71713427
149Abnormal glycosylation (HP:0012345)1.71713427
150Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71713427
151Abnormal protein N-linked glycosylation (HP:0012347)1.71713427
152Intestinal atresia (HP:0011100)1.71631382
153Glioma (HP:0009733)1.69812532
154Abnormality of the vitamin B12 metabolism (HP:0004341)1.67773021
155Megaloblastic anemia (HP:0001889)1.66940188
156Abnormality of the fovea (HP:0000493)1.66282176

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.08361930
2BUB13.94505187
3CDC73.73692419
4STK163.71864982
5EIF2AK13.59827446
6TRIM283.55527402
7PLK42.98767376
8ACVR1B2.73598605
9MAP4K22.60091819
10NUAK12.56933432
11VRK12.52723934
12NME22.52411819
13SRPK12.47996623
14NEK22.46981340
15DYRK32.42450749
16EIF2AK32.29690003
17TTK2.15792906
18RPS6KA42.10971208
19BCR1.94796978
20TLK11.93599059
21BRSK21.90849774
22ERBB31.85317270
23MKNK11.80082435
24PLK11.78737113
25TESK21.74865373
26VRK21.67547395
27RPS6KB21.66645751
28AURKB1.65151099
29WNK31.63560977
30MAP3K41.53328427
31CDK71.51444875
32PASK1.48258399
33ATR1.47156572
34PBK1.42967096
35EEF2K1.42488141
36CHEK21.40181056
37TNIK1.40180604
38MUSK1.33480961
39KDR1.31456413
40MAP3K81.25455117
41MAP2K71.23759235
42MKNK21.23163462
43CDK81.17498097
44BRSK11.15743100
45STK101.14246087
46DYRK21.13495834
47AURKA1.11803833
48RPS6KA51.10074143
49SCYL21.09101193
50MAPKAPK31.08549229
51STK391.08296746
52TGFBR11.07041588
53CSNK1G21.03186840
54PLK21.02038044
55PAK40.99689780
56BRAF0.98844963
57PLK30.98595251
58FLT30.96510751
59CHEK10.95544554
60PIM20.93863986
61NEK10.92863128
62STK40.90263200
63LRRK20.89090199
64MAP4K10.88224575
65SIK30.88181469
66CDK40.87605619
67CCNB10.85540711
68FRK0.83511626
69PIM10.78203511
70MAP3K120.78118816
71TSSK60.77579358
72OXSR10.76417315
73MAPK130.75795776
74ZAK0.75181994
75BCKDK0.75113725
76TEC0.74437144
77EIF2AK20.73589635
78IRAK40.72861124
79ATM0.72020210
80STK38L0.71987642
81INSRR0.70032081
82BRD40.68655113
83CASK0.67731879
84NME10.67508890
85GRK10.67179839
86CDK190.66967767
87CSNK2A10.64593039
88TXK0.63122723
89RAF10.62881155
90TAF10.59872573
91CDK20.59569965
92MELK0.59215841
93ABL20.57654264
94MAPKAPK50.57532443
95BTK0.56338353
96PAK10.54994408
97CSNK2A20.53483432
98STK30.52259989
99DAPK10.50906844
100MAP3K60.49732745
101YES10.49301932
102KIT0.49124532
103CSNK1G30.48579381
104LIMK10.47446311
105CDK10.46906833
106MAP3K100.46322112
107MINK10.44227709
108NEK60.44102135
109ILK0.43648376
110ADRBK20.43103540
111ARAF0.39985930
112EPHA20.38930219
113PINK10.37011237
114MAPK110.36813969
115PDK20.36713171
116MAP3K110.34789650
117TIE10.34375365
118CLK10.34349105
119DYRK1B0.34047905
120PRKCE0.33539456
121WNK40.33316933
122LYN0.33207580
123CSNK1G10.32462087
124OBSCN0.32029135
125TESK10.31942312
126MST40.30594457
127PRKCG0.28580790
128NEK90.28495562
129ZAP700.28296117
130TAOK30.28054743
131NLK0.27793673
132CDK60.27625152
133CSF1R0.27127610
134BMPR1B0.26472920
135PRKCI0.24601803
136CDK90.24438348
137CSNK1A1L0.23611394
138ERBB40.22009810

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.02782177
2Ribosome_Homo sapiens_hsa030104.15052373
3Mismatch repair_Homo sapiens_hsa034304.02875893
4RNA polymerase_Homo sapiens_hsa030203.32153161
5Proteasome_Homo sapiens_hsa030503.29472895
6Spliceosome_Homo sapiens_hsa030403.20717622
7Homologous recombination_Homo sapiens_hsa034403.18735895
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03809351
9Base excision repair_Homo sapiens_hsa034103.03580454
10Nucleotide excision repair_Homo sapiens_hsa034202.81101671
11Cell cycle_Homo sapiens_hsa041102.80423843
12RNA transport_Homo sapiens_hsa030132.72908063
13Pyrimidine metabolism_Homo sapiens_hsa002402.66869783
14Fanconi anemia pathway_Homo sapiens_hsa034602.25417290
15RNA degradation_Homo sapiens_hsa030182.14805094
16Basal transcription factors_Homo sapiens_hsa030222.13394154
17One carbon pool by folate_Homo sapiens_hsa006702.12825178
18Non-homologous end-joining_Homo sapiens_hsa034502.04525669
19Protein export_Homo sapiens_hsa030601.97147159
20Propanoate metabolism_Homo sapiens_hsa006401.85714172
21Fatty acid elongation_Homo sapiens_hsa000621.72360176
22p53 signaling pathway_Homo sapiens_hsa041151.60452683
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57877605
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57796904
25Systemic lupus erythematosus_Homo sapiens_hsa053221.51310454
26Steroid biosynthesis_Homo sapiens_hsa001001.48533639
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45704245
28Purine metabolism_Homo sapiens_hsa002301.41419039
29mRNA surveillance pathway_Homo sapiens_hsa030151.39259722
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34528413
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29992675
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18741505
33Pyruvate metabolism_Homo sapiens_hsa006201.16255983
34Folate biosynthesis_Homo sapiens_hsa007901.15964812
35Epstein-Barr virus infection_Homo sapiens_hsa051691.10187507
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00799590
37Herpes simplex infection_Homo sapiens_hsa051680.97296334
38Parkinsons disease_Homo sapiens_hsa050120.97200282
39Butanoate metabolism_Homo sapiens_hsa006500.96354305
40Huntingtons disease_Homo sapiens_hsa050160.94590193
41Peroxisome_Homo sapiens_hsa041460.90061142
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87493132
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87416021
44Viral carcinogenesis_Homo sapiens_hsa052030.86894470
45Oocyte meiosis_Homo sapiens_hsa041140.85230998
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85104646
47Sulfur relay system_Homo sapiens_hsa041220.83067530
48Pentose phosphate pathway_Homo sapiens_hsa000300.82995468
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.80888386
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76689198
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76515981
52Oxidative phosphorylation_Homo sapiens_hsa001900.74841862
53Phototransduction_Homo sapiens_hsa047440.74187046
54Primary immunodeficiency_Homo sapiens_hsa053400.72533949
55Antigen processing and presentation_Homo sapiens_hsa046120.66622224
56HTLV-I infection_Homo sapiens_hsa051660.64500657
57Selenocompound metabolism_Homo sapiens_hsa004500.64319090
58Fatty acid metabolism_Homo sapiens_hsa012120.64191077
59Olfactory transduction_Homo sapiens_hsa047400.62498379
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61906673
61Vitamin B6 metabolism_Homo sapiens_hsa007500.58087958
62Small cell lung cancer_Homo sapiens_hsa052220.57299244
63MicroRNAs in cancer_Homo sapiens_hsa052060.56602444
64Glutathione metabolism_Homo sapiens_hsa004800.56560729
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56375839
66Alcoholism_Homo sapiens_hsa050340.56335380
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.53435162
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52810461
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52526176
70Thyroid cancer_Homo sapiens_hsa052160.52069656
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50653443
72Shigellosis_Homo sapiens_hsa051310.49688527
73Nicotine addiction_Homo sapiens_hsa050330.49562886
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48938628
75Legionellosis_Homo sapiens_hsa051340.45787561
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45656576
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45515362
78Nitrogen metabolism_Homo sapiens_hsa009100.44260460
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43518374
80Sulfur metabolism_Homo sapiens_hsa009200.43169269
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42639649
82Cardiac muscle contraction_Homo sapiens_hsa042600.40894984
83Hepatitis B_Homo sapiens_hsa051610.39922803
84Alzheimers disease_Homo sapiens_hsa050100.37688667
85Colorectal cancer_Homo sapiens_hsa052100.37321612
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36092192
87Notch signaling pathway_Homo sapiens_hsa043300.35632066
88Collecting duct acid secretion_Homo sapiens_hsa049660.35201012
89Measles_Homo sapiens_hsa051620.34820151
90beta-Alanine metabolism_Homo sapiens_hsa004100.34657912
91N-Glycan biosynthesis_Homo sapiens_hsa005100.34330599
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34084074
93TGF-beta signaling pathway_Homo sapiens_hsa043500.34019731
94Hematopoietic cell lineage_Homo sapiens_hsa046400.33847437
95Apoptosis_Homo sapiens_hsa042100.33641159
96Retinol metabolism_Homo sapiens_hsa008300.33182118
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31974091
98Linoleic acid metabolism_Homo sapiens_hsa005910.31149510
99Metabolic pathways_Homo sapiens_hsa011000.30983252
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.29874705
101Biosynthesis of amino acids_Homo sapiens_hsa012300.29405827
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29405493
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28640953
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.26916091
105Fatty acid degradation_Homo sapiens_hsa000710.25638190
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24091538
107Chronic myeloid leukemia_Homo sapiens_hsa052200.23500866
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23366532
109Circadian rhythm_Homo sapiens_hsa047100.22861870
110Taste transduction_Homo sapiens_hsa047420.22678410
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22424311
112Asthma_Homo sapiens_hsa053100.22249604
113Vitamin digestion and absorption_Homo sapiens_hsa049770.20439551
114Caffeine metabolism_Homo sapiens_hsa002320.19663284
115Tryptophan metabolism_Homo sapiens_hsa003800.19606577
116Hippo signaling pathway_Homo sapiens_hsa043900.19382469
117Regulation of autophagy_Homo sapiens_hsa041400.19100644
118Pancreatic cancer_Homo sapiens_hsa052120.18955203
119Pathways in cancer_Homo sapiens_hsa052000.18513213
120Arachidonic acid metabolism_Homo sapiens_hsa005900.17852429
121Ether lipid metabolism_Homo sapiens_hsa005650.17364180
122Bladder cancer_Homo sapiens_hsa052190.17136565
123Influenza A_Homo sapiens_hsa051640.17111577
124Basal cell carcinoma_Homo sapiens_hsa052170.17088441
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.16297802
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15363244
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.14423086
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14417850
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14365254
130Allograft rejection_Homo sapiens_hsa053300.14248656
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14234765
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13412850
133Wnt signaling pathway_Homo sapiens_hsa043100.13278652
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10768272
135Carbon metabolism_Homo sapiens_hsa012000.10628201
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.10426481
137Leishmaniasis_Homo sapiens_hsa051400.10177384
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.09577265
139Hedgehog signaling pathway_Homo sapiens_hsa043400.09443792

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