ASF1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nitric oxide mediated signal transduction (GO:0007263)9.92465162
2regulation of type B pancreatic cell apoptotic process (GO:2000674)9.77891189
3L-alpha-amino acid transmembrane transport (GO:1902475)9.48661455
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)7.82948924
5response to hepatocyte growth factor (GO:0035728)7.52172278
6cellular response to hepatocyte growth factor stimulus (GO:0035729)7.52172278
7nodal signaling pathway (GO:0038092)7.43004012
8plasma membrane repair (GO:0001778)7.00421512
9insulin secretion (GO:0030073)6.93452761
10exocrine pancreas development (GO:0031017)6.71429988
11cellular response to vitamin D (GO:0071305)6.60890081
12glandular epithelial cell differentiation (GO:0002067)6.59748608
13endocrine pancreas development (GO:0031018)6.28423309
14response to lipoprotein particle (GO:0055094)6.02038273
15positive regulation of insulin secretion (GO:0032024)5.86606692
16chemosensory behavior (GO:0007635)5.84241190
17protein localization to kinetochore (GO:0034501)5.61615407
18Golgi transport vesicle coating (GO:0048200)5.59132476
19COPI coating of Golgi vesicle (GO:0048205)5.59132476
20type B pancreatic cell development (GO:0003323)5.55226721
21DNA strand elongation involved in DNA replication (GO:0006271)5.54989086
22telomere maintenance via semi-conservative replication (GO:0032201)5.45902492
23DNA strand elongation (GO:0022616)5.26942325
24attachment of spindle microtubules to kinetochore (GO:0008608)5.26740600
25positive regulation of glycolytic process (GO:0045821)5.25994695
26regulation of insulin secretion (GO:0050796)5.08359596
27CENP-A containing nucleosome assembly (GO:0034080)5.02974680
28detection of calcium ion (GO:0005513)5.02531069
29DNA replication checkpoint (GO:0000076)5.01573938
30telomere maintenance via recombination (GO:0000722)5.01410620
31protein localization to chromosome, centromeric region (GO:0071459)4.99065355
32succinate metabolic process (GO:0006105)4.98418893
33mitotic metaphase plate congression (GO:0007080)4.95905702
34DNA replication initiation (GO:0006270)4.95447115
35peptide hormone processing (GO:0016486)4.93564402
36chromatin remodeling at centromere (GO:0031055)4.92914131
37synaptic vesicle docking involved in exocytosis (GO:0016081)4.92154657
38negative regulation of gluconeogenesis (GO:0045721)4.91681544
39mitotic chromosome condensation (GO:0007076)4.90561355
40mitotic recombination (GO:0006312)4.88044364
41positive regulation of peptide hormone secretion (GO:0090277)4.84392724
42response to glucose (GO:0009749)4.74152234
43peptide hormone secretion (GO:0030072)4.72320706
44protein maturation by protein folding (GO:0022417)4.71527421
45kinetochore organization (GO:0051383)4.66649479
46positive regulation of peptide secretion (GO:0002793)4.66395456
47cellular response to vitamin (GO:0071295)4.62183799
48peptide secretion (GO:0002790)4.59816376
49DNA unwinding involved in DNA replication (GO:0006268)4.59319126
50mitotic sister chromatid segregation (GO:0000070)4.55721895
51regulation of peptide hormone secretion (GO:0090276)4.49227144
52nucleoside diphosphate catabolic process (GO:0009134)4.48930635
53response to hexose (GO:0009746)4.46402085
54cellular zinc ion homeostasis (GO:0006882)4.41514613
55regulation of peptide secretion (GO:0002791)4.40463331
56metaphase plate congression (GO:0051310)4.34666373
57macroautophagy (GO:0016236)4.30003182
58negative regulation of hormone biosynthetic process (GO:0032353)4.29864977
59meiotic chromosome segregation (GO:0045132)4.27496797
60glucose 6-phosphate metabolic process (GO:0051156)4.25694241
61establishment of chromosome localization (GO:0051303)4.24911578
62* DNA replication-independent nucleosome organization (GO:0034724)4.24830368
63* DNA replication-independent nucleosome assembly (GO:0006336)4.24830368
64response to monosaccharide (GO:0034284)4.23686265
65telomere maintenance via telomere lengthening (GO:0010833)4.21750084
66nucleotide-excision repair, DNA gap filling (GO:0006297)4.21367159
67regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.19867726
68kinetochore assembly (GO:0051382)4.17028087
69histone exchange (GO:0043486)4.15077472
70sister chromatid segregation (GO:0000819)4.13876567
71positive regulation of calcium ion import (GO:0090280)4.08392631
72regulation of glucocorticoid metabolic process (GO:0031943)4.07887997
73glandular epithelial cell development (GO:0002068)4.06216809
74positive regulation of macroautophagy (GO:0016239)4.01277086
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.99427577
76mitotic nuclear envelope disassembly (GO:0007077)3.98936958
77response to parathyroid hormone (GO:0071107)3.94289452
78regulation of spindle organization (GO:0090224)3.93898990
79positive regulation of Rap GTPase activity (GO:0032854)3.93690605
80protein retention in ER lumen (GO:0006621)3.83565821
81response to dietary excess (GO:0002021)3.75582323
82maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.73652472
83positive regulation of neurotransmitter secretion (GO:0001956)3.71274521
84regulation of hormone secretion (GO:0046883)3.70510218
85negative regulation of hormone metabolic process (GO:0032351)3.68453132
86toxin transport (GO:1901998)3.68253059
87nuclear envelope disassembly (GO:0051081)3.68022418
88membrane disassembly (GO:0030397)3.68022418
89protein localization to chromosome (GO:0034502)3.65656972
90negative regulation of cytosolic calcium ion concentration (GO:0051481)3.63558891
91regulation of calcium ion-dependent exocytosis (GO:0017158)3.61999224
92regulation of double-strand break repair via homologous recombination (GO:0010569)3.61472797
93chromosome segregation (GO:0007059)3.61255067
94hormone secretion (GO:0046879)3.56087366
95regulation of peptide transport (GO:0090087)3.55820499
96deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.54984543
97adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.54431853
98spindle checkpoint (GO:0031577)3.52446572
99positive regulation of hormone secretion (GO:0046887)3.50259546
100sequestering of metal ion (GO:0051238)3.49408270
101positive regulation of chromosome segregation (GO:0051984)3.44499759
102ribosomal small subunit assembly (GO:0000028)3.43481506
103regulation of chromosome segregation (GO:0051983)3.42885339
104peptide transport (GO:0015833)3.41951015
105response to carbohydrate (GO:0009743)3.41708966
106nucleobase biosynthetic process (GO:0046112)3.41474646
107negative regulation of catecholamine secretion (GO:0033604)3.36824947
108response to ischemia (GO:0002931)3.36495411
109cellular response to glucagon stimulus (GO:0071377)3.36038626
110ER overload response (GO:0006983)3.35955794
111telomere maintenance (GO:0000723)3.34237431
112positive regulation of exocytosis (GO:0045921)3.34056211
113telomere organization (GO:0032200)3.32821919
114calcium ion import (GO:0070509)3.30173833
115* chromatin assembly or disassembly (GO:0006333)3.29420299
116* DNA replication-dependent nucleosome organization (GO:0034723)3.28389791
117* DNA replication-dependent nucleosome assembly (GO:0006335)3.28389791
118protein K6-linked ubiquitination (GO:0085020)3.25499551
119ATP-dependent chromatin remodeling (GO:0043044)3.24229294
120negative regulation of chromosome segregation (GO:0051985)3.23713387
121regulation of Rap GTPase activity (GO:0032317)3.23091728
122activin receptor signaling pathway (GO:0032924)3.22648851
123hormone transport (GO:0009914)3.22492086
124negative regulation of mitotic sister chromatid separation (GO:2000816)3.21657426
125negative regulation of mitotic sister chromatid segregation (GO:0033048)3.21657426
126negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.21657426
127negative regulation of sister chromatid segregation (GO:0033046)3.21657426
128somatic hypermutation of immunoglobulin genes (GO:0016446)3.21050165
129somatic diversification of immune receptors via somatic mutation (GO:0002566)3.21050165
130peptide biosynthetic process (GO:0043043)3.20941659
131spindle assembly checkpoint (GO:0071173)3.20903983
132negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.20331445
133maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.19751555
134chromosome condensation (GO:0030261)3.18529616
135regulation of mitotic metaphase/anaphase transition (GO:0030071)3.18074532
136anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17862084
137mitotic cell cycle (GO:0000278)3.17563651
138regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.17131340
139histone-serine phosphorylation (GO:0035404)3.17061140
140deoxyribonucleotide biosynthetic process (GO:0009263)3.16785936
141production of molecular mediator involved in inflammatory response (GO:0002532)3.14922838
142DNA deamination (GO:0045006)3.14842857
143COPII vesicle coating (GO:0048208)3.14551266
144mismatch repair (GO:0006298)3.13829283
145transcription-coupled nucleotide-excision repair (GO:0006283)3.12717787
146nuclear pore organization (GO:0006999)3.12022982
147purine nucleobase biosynthetic process (GO:0009113)3.10868100
148mitotic spindle assembly checkpoint (GO:0007094)3.09677205
149dicarboxylic acid catabolic process (GO:0043649)3.09348786
150cell cycle G1/S phase transition (GO:0044843)3.09104207
151G1/S transition of mitotic cell cycle (GO:0000082)3.09104207
152regulation of centrosome cycle (GO:0046605)3.08246715
153retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.07023997
154response to leptin (GO:0044321)3.06854227
155folic acid-containing compound biosynthetic process (GO:0009396)3.05973450
156DNA synthesis involved in DNA repair (GO:0000731)3.04081734
157mitotic spindle checkpoint (GO:0071174)3.03404996
158regulation of mitotic spindle organization (GO:0060236)3.02979593
159fatty acid homeostasis (GO:0055089)3.02528440
160cerebellar Purkinje cell layer development (GO:0021680)3.01799620
161regulation of autophagic vacuole assembly (GO:2000785)3.01423900
162regulation of sister chromatid segregation (GO:0033045)3.00646005
163regulation of mitotic sister chromatid separation (GO:0010965)3.00646005
164regulation of mitotic sister chromatid segregation (GO:0033047)3.00646005
165mitotic sister chromatid cohesion (GO:0007064)2.99659716
166protein localization to endosome (GO:0036010)2.98159708
167maturation of SSU-rRNA (GO:0030490)2.98093018
168positive regulation of neurotransmitter transport (GO:0051590)2.97810011
169post-embryonic morphogenesis (GO:0009886)2.97737393
170maturation of 5.8S rRNA (GO:0000460)2.96894898
171formation of translation preinitiation complex (GO:0001731)2.96095067
172nuclear pore complex assembly (GO:0051292)2.95708010
173regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95308009
174positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.94765374
175positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.94765374
176positive regulation of mitotic sister chromatid separation (GO:1901970)2.94765374
177response to gravity (GO:0009629)2.94098989
178DNA topological change (GO:0006265)2.93689708
179DNA packaging (GO:0006323)2.92626035
180regulation of sister chromatid cohesion (GO:0007063)2.92124140
181cellular response to prostaglandin stimulus (GO:0071379)2.91008464
182IMP biosynthetic process (GO:0006188)2.89977706
183translesion synthesis (GO:0019985)2.89270974
184negative regulation of erythrocyte differentiation (GO:0045647)2.88642926
185positive regulation of glycogen biosynthetic process (GO:0045725)2.87797454
186signal release (GO:0023061)2.87656439
187regulation of steroid hormone biosynthetic process (GO:0090030)2.87570991
188protein targeting to vacuole (GO:0006623)2.87441290
189protein targeting to lysosome (GO:0006622)2.87441290
190establishment of protein localization to vacuole (GO:0072666)2.87441290
191amide transport (GO:0042886)2.87184110
192epithelial cell maturation (GO:0002070)2.86408307
193base-excision repair (GO:0006284)2.86136950
194replication fork processing (GO:0031297)2.85676825
195DNA replication (GO:0006260)2.85007580
196nuclear envelope organization (GO:0006998)2.84669186
197regulation of gluconeogenesis (GO:0006111)2.83596465
198positive regulation of response to extracellular stimulus (GO:0032106)2.83129910
199positive regulation of response to nutrient levels (GO:0032109)2.83129910
200regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:190223511.2481951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.89925475
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.84139068
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.33998552
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.93312846
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.46937746
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.46780101
7* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18319232
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.57900552
9AR_21909140_ChIP-Seq_LNCAP_Human2.57310462
10ZNF263_19887448_ChIP-Seq_K562_Human2.52625596
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.49918108
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44148662
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43794242
14* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.43417156
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41166108
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40356906
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36092751
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.33544434
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.31016160
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.30411704
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.22444582
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19099336
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12647581
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10583986
25VDR_23849224_ChIP-Seq_CD4+_Human2.09031416
26HTT_18923047_ChIP-ChIP_STHdh_Human2.05190916
27XRN2_22483619_ChIP-Seq_HELA_Human2.04269025
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.04179959
29E2F7_22180533_ChIP-Seq_HELA_Human10.1845603
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97122461
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97121367
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96262600
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93833675
34DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.93451905
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.93177641
36FOXP3_21729870_ChIP-Seq_TREG_Human1.88902185
37* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87605722
38DCP1A_22483619_ChIP-Seq_HELA_Human1.84287414
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81669760
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.78113365
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.75251256
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.74320017
43* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73575009
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72002603
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69872406
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.69112629
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.68416324
48TET1_21490601_ChIP-Seq_MESCs_Mouse1.68289092
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66825670
50GABP_19822575_ChIP-Seq_HepG2_Human1.66197769
51RACK7_27058665_Chip-Seq_MCF-7_Human1.64219957
52SMC4_20622854_ChIP-Seq_HELA_Human1.63782229
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63698501
54MYC_22102868_ChIP-Seq_BL_Human1.63216673
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.62119163
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60571126
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.58208937
58* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57549470
59TTF2_22483619_ChIP-Seq_HELA_Human1.55448213
60SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.54360217
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53274698
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52680926
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50820828
64LXR_22292898_ChIP-Seq_THP-1_Human1.50093549
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.49964857
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.48818993
67CIITA_25753668_ChIP-Seq_RAJI_Human1.48566979
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47586245
69* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47456956
70ELK1_19687146_ChIP-ChIP_HELA_Human1.47111631
71SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.46054009
72* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44803159
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44717876
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44247270
75SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.44224158
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42211607
77* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41965550
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40654689
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38402540
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37262737
81* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.35765352
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35019586
83DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33716337
84TRIM28_21343339_ChIP-Seq_HEK293_Human1.32206627
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31519898
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30309140
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.29120226
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28569773
89* KDM5A_27292631_Chip-Seq_BREAST_Human1.27917556
90REST_19997604_ChIP-ChIP_NEURONS_Mouse1.27851112
91SRF_21415370_ChIP-Seq_HL-1_Mouse1.27640746
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.27487646
93* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27217088
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26978450
95CLOCK_20551151_ChIP-Seq_293T_Human1.26564148
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25906256
97* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25495061
98YY1_21170310_ChIP-Seq_MESCs_Mouse1.25251767
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24839828
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23857072
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23701465
102* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23448103
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21320324
104RARB_27405468_Chip-Seq_BRAIN_Mouse1.20583235
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20440412
106* VDR_21846776_ChIP-Seq_THP-1_Human1.20348284
107E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19973282
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19680145
109SPI1_23547873_ChIP-Seq_NB4_Human1.17095107
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13391075
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12959554
112IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10523979
113KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08661402
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06741755
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06037632
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06011577
117* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05592988
118IRF8_21731497_ChIP-ChIP_J774_Mouse1.04795271
119PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04324386
120NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03758833
121KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03212772
122MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02916994
123RNF2_27304074_Chip-Seq_ESCs_Mouse1.00252192
124CBX2_27304074_Chip-Seq_ESCs_Mouse0.99260254
125MYC_18940864_ChIP-ChIP_HL60_Human0.98906068
126WT1_19549856_ChIP-ChIP_CCG9911_Human0.98537128
127CHD1_26751641_Chip-Seq_LNCaP_Human0.98096533
128SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98079394
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97825973
130TFEB_21752829_ChIP-Seq_HELA_Human0.96222430
131TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95956024
132RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95912073
133POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95698548
134SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95537414
135* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94842327
136MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94069782
137NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94053429
138* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93669374
139SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92006226
140* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91778940
141* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91197770
142NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91088948
143CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90701933
144SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90032169
145TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.89061655
146MYB_26560356_Chip-Seq_TH2_Human0.87772854
147* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86773902
148BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86570311
149* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86338791
150STAT4_19710469_ChIP-ChIP_TH1__Mouse0.85685181
151POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84719511
152CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84437278
153TP63_19390658_ChIP-ChIP_HaCaT_Human0.84116280
154UTX_26944678_Chip-Seq_JUKART_Human0.81652958
155GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79579035
156ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79195439
157TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78798341
158HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.78796287
159MYB_26560356_Chip-Seq_TH1_Human0.77914094
160IRF8_22096565_ChIP-ChIP_GC-B_Human0.77883568
161CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75747409
162NOTCH1_21737748_ChIP-Seq_TLL_Human0.75305113
163SOX2_18555785_ChIP-Seq_MESCs_Mouse0.74779254
164GATA2_22383799_ChIP-Seq_G1ME_Mouse0.73113017
165HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.72797052
166SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.72368672
167RUNX1_22412390_ChIP-Seq_EML_Mouse0.72211814
168* MAF_26560356_Chip-Seq_TH1_Human0.72166835

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ9.24918731
2MP0003693_abnormal_embryo_hatching6.19965587
3MP0003195_calcinosis5.98239806
4MP0002909_abnormal_adrenal_gland5.46178010
5MP0010094_abnormal_chromosome_stability5.23338396
6MP0004510_myositis5.13442428
7MP0003111_abnormal_nucleus_morphology4.88621944
8MP0008057_abnormal_DNA_replication4.30683837
9MP0002693_abnormal_pancreas_physiology4.26689074
10MP0003077_abnormal_cell_cycle4.23768767
11MP0004957_abnormal_blastocyst_morpholog4.23706160
12MP0003787_abnormal_imprinting3.93606294
13MP0001944_abnormal_pancreas_morphology3.20335498
14MP0008058_abnormal_DNA_repair3.19304660
15MP0003122_maternal_imprinting2.94824786
16MP0000462_abnormal_digestive_system2.79800221
17MP0008007_abnormal_cellular_replicative2.77371028
18MP0000678_abnormal_parathyroid_gland2.75699573
19MP0002396_abnormal_hematopoietic_system2.64081226
20MP0003045_fibrosis2.58551377
21MP0008932_abnormal_embryonic_tissue2.54084034
22MP0008877_abnormal_DNA_methylation2.52854664
23MP0005379_endocrine/exocrine_gland_phen2.31263954
24MP0009780_abnormal_chondrocyte_physiolo2.26344657
25MP0005220_abnormal_exocrine_pancreas2.08639822
26MP0003172_abnormal_lysosome_physiology2.08598194
27MP0005058_abnormal_lysosome_morphology2.08097854
28MP0000350_abnormal_cell_proliferation2.05863296
29MP0001730_embryonic_growth_arrest2.05357004
30MP0002078_abnormal_glucose_homeostasis2.01219489
31MP0000490_abnormal_crypts_of1.94802206
32MP0010307_abnormal_tumor_latency1.91808049
33MP0003786_premature_aging1.91718197
34MP0003123_paternal_imprinting1.89239005
35MP0003763_abnormal_thymus_physiology1.88923968
36MP0010352_gastrointestinal_tract_polyps1.86458778
37MP0002822_catalepsy1.84746079
38MP0003718_maternal_effect1.78326423
39MP0002928_abnormal_bile_duct1.74199224
40MP0002019_abnormal_tumor_incidence1.73946839
41MP0004808_abnormal_hematopoietic_stem1.71584933
42MP0002398_abnormal_bone_marrow1.69653668
43MP0002168_other_aberrant_phenotype1.65063865
44MP0003300_gastrointestinal_ulcer1.63447004
45MP0001835_abnormal_antigen_presentation1.62502030
46MP0004270_analgesia1.62416223
47MP0009333_abnormal_splenocyte_physiolog1.60643999
48MP0005397_hematopoietic_system_phenotyp1.56858131
49MP0001545_abnormal_hematopoietic_system1.56858131
50MP0000313_abnormal_cell_death1.50506843
51MP0000689_abnormal_spleen_morphology1.48290036
52MP0003656_abnormal_erythrocyte_physiolo1.46973425
53MP0002722_abnormal_immune_system1.46036227
54MP0001697_abnormal_embryo_size1.41747665
55MP0000703_abnormal_thymus_morphology1.40866079
56MP0000003_abnormal_adipose_tissue1.37555181
57MP0001800_abnormal_humoral_immune1.36487988
58MP0005380_embryogenesis_phenotype1.32394516
59MP0001672_abnormal_embryogenesis/_devel1.32394516
60MP0002080_prenatal_lethality1.31941078
61MP0002210_abnormal_sex_determination1.31479887
62MP0000516_abnormal_urinary_system1.31381185
63MP0005367_renal/urinary_system_phenotyp1.31381185
64MP0002877_abnormal_melanocyte_morpholog1.30036233
65MP0002429_abnormal_blood_cell1.28333600
66MP0005671_abnormal_response_to1.27562032
67MP0008004_abnormal_stomach_pH1.25861023
68MP0002420_abnormal_adaptive_immunity1.23316116
69MP0000716_abnormal_immune_system1.22123556
70MP0010386_abnormal_urinary_bladder1.21972641
71MP0001929_abnormal_gametogenesis1.21873940
72MP0003953_abnormal_hormone_level1.21525703
73MP0001819_abnormal_immune_cell1.20780017
74MP0002452_abnormal_antigen_presenting1.20303349
75MP0003866_abnormal_defecation1.19441965
76MP0003984_embryonic_growth_retardation1.17566793
77MP0005448_abnormal_energy_balance1.16732256
78MP0005257_abnormal_intraocular_pressure1.12578374
79MP0004147_increased_porphyrin_level1.12547945
80MP0002088_abnormal_embryonic_growth/wei1.12537588
81MP0001145_abnormal_male_reproductive1.11642831
82MP0000858_altered_metastatic_potential1.11488070
83MP0001119_abnormal_female_reproductive1.09529843
84MP0002090_abnormal_vision1.09471802
85MP0003186_abnormal_redox_activity1.09409975
86MP0002085_abnormal_embryonic_tissue1.08515059
87MP0009643_abnormal_urine_homeostasis1.06129841
88MP0000653_abnormal_sex_gland1.05426350
89MP0010234_abnormal_vibrissa_follicle1.04403938
90MP0002405_respiratory_system_inflammati1.04155613
91MP0009785_altered_susceptibility_to1.04018548
92MP0002086_abnormal_extraembryonic_tissu1.03838279
93MP0000013_abnormal_adipose_tissue1.03045997
94MP0002723_abnormal_immune_serum1.03016799
95MP0002163_abnormal_gland_morphology1.01956771
96MP0000685_abnormal_immune_system1.01468234
97MP0005000_abnormal_immune_tolerance0.98855805
98MP0001853_heart_inflammation0.98395266
99MP0003436_decreased_susceptibility_to0.97387060
100MP0006054_spinal_hemorrhage0.97341519
101MP0005645_abnormal_hypothalamus_physiol0.97079717
102MP0009046_muscle_twitch0.93980099
103MP0002132_abnormal_respiratory_system0.93319447
104MP0005025_abnormal_response_to0.92568504
105MP0005076_abnormal_cell_differentiation0.90170259
106MP0000470_abnormal_stomach_morphology0.89738194
107MP0003806_abnormal_nucleotide_metabolis0.89038954
108MP0002970_abnormal_white_adipose0.89009090
109MP0005248_abnormal_Harderian_gland0.87997646
110MP0003121_genomic_imprinting0.86511415
111MP0002006_tumorigenesis0.86313208
112MP0003567_abnormal_fetal_cardiomyocyte0.83514410
113MP0005464_abnormal_platelet_physiology0.82652851
114MP0003315_abnormal_perineum_morphology0.81288882
115MP0005451_abnormal_body_composition0.80865248
116MP0002084_abnormal_developmental_patter0.80620787
117MP0009672_abnormal_birth_weight0.80517543
118MP0002419_abnormal_innate_immunity0.79961994
119MP0004197_abnormal_fetal_growth/weight/0.78925785
120MP0003943_abnormal_hepatobiliary_system0.78603126
121MP0005621_abnormal_cell_physiology0.78363903
122MP0003879_abnormal_hair_cell0.77919878
123MP0002177_abnormal_outer_ear0.77793257
124MP0005384_cellular_phenotype0.75673925
125MP0002896_abnormal_bone_mineralization0.75571809
126MP0003183_abnormal_peptide_metabolism0.75348428
127MP0002108_abnormal_muscle_morphology0.75130878
128MP0010155_abnormal_intestine_physiology0.74564988
129MP0002139_abnormal_hepatobiliary_system0.73950654
130MP0000465_gastrointestinal_hemorrhage0.73876380
131MP0000569_abnormal_digit_pigmentation0.73588021
132MP0005075_abnormal_melanosome_morpholog0.73508572
133MP0001873_stomach_inflammation0.73090806
134MP0001790_abnormal_immune_system0.72393694
135MP0005387_immune_system_phenotype0.72393694
136MP0003119_abnormal_digestive_system0.71912627
137MP0001727_abnormal_embryo_implantation0.71729463
138MP0005395_other_phenotype0.71449078
139MP0003448_altered_tumor_morphology0.70137973
140MP0005389_reproductive_system_phenotype0.69612559
141MP0005023_abnormal_wound_healing0.69229455
142MP0001765_abnormal_ion_homeostasis0.68944899
143MP0003699_abnormal_female_reproductive0.68169053
144MP0002166_altered_tumor_susceptibility0.67880491
145MP0004133_heterotaxia0.67630328
146MP0001756_abnormal_urination0.67213299
147MP0006036_abnormal_mitochondrial_physio0.66924290
148MP0006292_abnormal_olfactory_placode0.66676319
149MP0000358_abnormal_cell_content/0.66450578
150MP0002148_abnormal_hypersensitivity_rea0.66166131
151MP0002160_abnormal_reproductive_system0.64683148
152MP0001915_intracranial_hemorrhage0.63814957
153MP0001919_abnormal_reproductive_system0.63168708
154MP0000015_abnormal_ear_pigmentation0.62553343
155MP0001845_abnormal_inflammatory_respons0.61646052
156MP0005408_hypopigmentation0.61248652
157MP0009278_abnormal_bone_marrow0.59939120
158MP0003566_abnormal_cell_adhesion0.59142798
159MP0002095_abnormal_skin_pigmentation0.58883280
160MP0003221_abnormal_cardiomyocyte_apopto0.58716777
161MP0004036_abnormal_muscle_relaxation0.58641370
162MP0001731_abnormal_postnatal_growth0.58442259
163MP0004859_abnormal_synaptic_plasticity0.58416815
164MP0003959_abnormal_lean_body0.57140437
165MP0001270_distended_abdomen0.56571259
166MP0002277_abnormal_respiratory_mucosa0.56534246
167MP0005452_abnormal_adipose_tissue0.55871661
168MP0001986_abnormal_taste_sensitivity0.53208331
169MP0005334_abnormal_fat_pad0.50394217
170MP0002060_abnormal_skin_morphology0.50118337
171MP0002971_abnormal_brown_adipose0.49418409
172MP0005332_abnormal_amino_acid0.49286851
173MP0009840_abnormal_foam_cell0.49247321
174MP0005266_abnormal_metabolism0.48913202
175MP0005636_abnormal_mineral_homeostasis0.48593550
176MP0003868_abnormal_feces_composition0.46771972
177MP0009642_abnormal_blood_homeostasis0.45613706
178MP0005375_adipose_tissue_phenotype0.44258820
179MP0005369_muscle_phenotype0.43868537
180MP0000759_abnormal_skeletal_muscle0.37980999
181MP0002118_abnormal_lipid_homeostasis0.37418865
182MP0005646_abnormal_pituitary_gland0.36492544
183MP0002069_abnormal_eating/drinking_beha0.36477631
184MP0005165_increased_susceptibility_to0.36441029
185MP0008438_abnormal_cutaneous_collagen0.36362635
186MP0003329_amyloid_beta_deposits0.34973633
187MP0001502_abnormal_circadian_rhythm0.33629903
188MP0002876_abnormal_thyroid_physiology0.33057574

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)8.79313703
2Symptomatic seizures (HP:0011145)7.91499086
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.79774026
4Abnormality of the pancreatic islet cells (HP:0006476)7.43218541
5Abnormality of endocrine pancreas physiology (HP:0012093)7.43218541
6Insulin-resistant diabetes mellitus (HP:0000831)7.24856627
7Late onset (HP:0003584)6.35188939
8Pancreatic islet-cell hyperplasia (HP:0004510)6.14062041
9Ketoacidosis (HP:0001993)6.06748827
10Hyperglycemia (HP:0003074)5.87452367
11Birth length less than 3rd percentile (HP:0003561)5.78792645
12Large for gestational age (HP:0001520)5.61001978
13Prominent metopic ridge (HP:0005487)5.41296808
14Insulin resistance (HP:0000855)4.84738244
15Increased circulating renin level (HP:0000848)4.82186737
16Chromsome breakage (HP:0040012)4.80389751
17Abnormality of the metopic suture (HP:0005556)4.68983813
18Hyperphosphatemia (HP:0002905)4.58918182
19Abnormal pancreas size (HP:0012094)4.45377349
20Chromosomal breakage induced by crosslinking agents (HP:0003221)4.39742338
21Congenital malformation of the right heart (HP:0011723)4.36527598
22Double outlet right ventricle (HP:0001719)4.36527598
23Abnormality of calcium-phosphate metabolism (HP:0100530)4.25974858
24Breast hypoplasia (HP:0003187)4.25049694
25Villous atrophy (HP:0011473)3.98637648
26Abnormality of small intestinal villus morphology (HP:0011472)3.98637648
27Hyperparathyroidism (HP:0000843)3.96033605
28Reticulocytopenia (HP:0001896)3.82040306
29Abnormality of chromosome stability (HP:0003220)3.70838139
30Truncus arteriosus (HP:0001660)3.70322633
31Patellar aplasia (HP:0006443)3.64848157
32Hyperthyroidism (HP:0000836)3.58250802
33EEG with generalized epileptiform discharges (HP:0011198)3.55144161
34Epileptiform EEG discharges (HP:0011182)3.49374511
35Hypsarrhythmia (HP:0002521)3.39970664
36Aplasia/Hypoplasia of the patella (HP:0006498)3.37735115
37Abnormal number of erythroid precursors (HP:0012131)3.34844771
38Ketosis (HP:0001946)3.34349561
39Menstrual irregularities (HP:0000858)3.33326232
40Abnormality of the preputium (HP:0100587)3.27211562
41Abnormality of cells of the erythroid lineage (HP:0012130)3.26037456
42Meckel diverticulum (HP:0002245)3.21688903
43Aplastic anemia (HP:0001915)3.21382891
44Carpal bone hypoplasia (HP:0001498)3.18082188
45Abnormality of the ileum (HP:0001549)3.03732753
46Basal ganglia calcification (HP:0002135)3.02565530
47Aplasia/Hypoplasia of the uvula (HP:0010293)3.01079067
48Oral leukoplakia (HP:0002745)2.92205228
49Duodenal stenosis (HP:0100867)2.89557851
50Small intestinal stenosis (HP:0012848)2.89557851
51J-shaped sella turcica (HP:0002680)2.88665800
52Myelodysplasia (HP:0002863)2.84639323
53Tetany (HP:0001281)2.79963100
54Abnormality of the heme biosynthetic pathway (HP:0010472)2.76270107
55Selective tooth agenesis (HP:0001592)2.75441961
56Hypoplasia of the capital femoral epiphysis (HP:0003090)2.75395657
57Abdominal situs inversus (HP:0003363)2.74966218
58Abnormality of abdominal situs (HP:0011620)2.74966218
59Bone marrow hypocellularity (HP:0005528)2.74509805
6011 pairs of ribs (HP:0000878)2.71063333
61Impulsivity (HP:0100710)2.68046593
62Degeneration of anterior horn cells (HP:0002398)2.67381565
63Abnormality of the anterior horn cell (HP:0006802)2.67381565
64Exocrine pancreatic insufficiency (HP:0001738)2.66268332
65Type I diabetes mellitus (HP:0100651)2.65692400
66Hypercortisolism (HP:0001578)2.58336227
67Nuclear cataract (HP:0100018)2.55882690
68Abnormal lung lobation (HP:0002101)2.54266384
69Unilateral renal agenesis (HP:0000122)2.53805466
70Absent thumb (HP:0009777)2.52786066
71Thrombocytosis (HP:0001894)2.51175881
72Ectopic kidney (HP:0000086)2.51014377
73Agnosia (HP:0010524)2.49249615
74Hypomagnesemia (HP:0002917)2.45194608
75IgM deficiency (HP:0002850)2.45092363
76Microretrognathia (HP:0000308)2.43502068
77Medulloblastoma (HP:0002885)2.42181487
78Sloping forehead (HP:0000340)2.42099300
79Rough bone trabeculation (HP:0100670)2.37758405
80Agitation (HP:0000713)2.37085442
81Abnormality of magnesium homeostasis (HP:0004921)2.34551671
82Duplicated collecting system (HP:0000081)2.34412553
83Clubbing of toes (HP:0100760)2.33970942
84Mitral stenosis (HP:0001718)2.31891077
85Combined immunodeficiency (HP:0005387)2.31873359
86Secondary amenorrhea (HP:0000869)2.31089719
87High pitched voice (HP:0001620)2.30137846
88Colon cancer (HP:0003003)2.30065306
89Lymphoma (HP:0002665)2.29257686
90Recurrent abscess formation (HP:0002722)2.27558664
91Absent radius (HP:0003974)2.26803888
92Enlarged penis (HP:0000040)2.26644985
93Abnormal spermatogenesis (HP:0008669)2.26289721
94Progressive sensorineural hearing impairment (HP:0000408)2.25318859
95Abnormality of the duodenum (HP:0002246)2.21203096
96Premature graying of hair (HP:0002216)2.20815876
97Hypokinesia (HP:0002375)2.20395946
98Abnormality of the carotid arteries (HP:0005344)2.19346802
99Pallor (HP:0000980)2.15881541
100Maternal diabetes (HP:0009800)2.14981174
101Cellular immunodeficiency (HP:0005374)2.13858803
102Petechiae (HP:0000967)2.13216000
103Increased nuchal translucency (HP:0010880)2.11776904
104Cafe-au-lait spot (HP:0000957)2.11654019
105IgG deficiency (HP:0004315)2.11559911
106Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.11349365
107Aplasia/Hypoplasia of the sacrum (HP:0008517)2.10093228
108Multiple enchondromatosis (HP:0005701)2.09968705
109Cleft eyelid (HP:0000625)2.09277144
110Tracheoesophageal fistula (HP:0002575)2.09030538
111Absent forearm bone (HP:0003953)2.08598403
112Aplasia involving forearm bones (HP:0009822)2.08598403
113Cellulitis (HP:0100658)2.08535190
114Growth hormone excess (HP:0000845)2.08408605
115B lymphocytopenia (HP:0010976)2.08285473
116Abnormality of B cell number (HP:0010975)2.08285473
117Slender long bone (HP:0003100)2.08166672
118Premature ovarian failure (HP:0008209)2.08054891
119Horseshoe kidney (HP:0000085)2.07130942
120Abnormality of the renal collecting system (HP:0004742)2.05999325
121Basal cell carcinoma (HP:0002671)2.05495750
122Recurrent viral infections (HP:0004429)2.04052638
123Absent epiphyses (HP:0010577)2.04027120
124Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.04027120
125Progressive hearing impairment (HP:0001730)2.01011861
126Hypoglycemic seizures (HP:0002173)11.4051000
127Hyperinsulinemic hypoglycemia (HP:0000825)10.2943175
128Testicular neoplasm (HP:0010788)1.98702713
129Cerebral hypomyelination (HP:0006808)1.98586885
130Downturned corners of mouth (HP:0002714)1.97967484
131Squamous cell carcinoma (HP:0002860)1.97662427
132Macrocytic anemia (HP:0001972)1.97633579
133Hypocalcemia (HP:0002901)1.97274973
134Abnormality of T cells (HP:0002843)1.97161332
135Short thumb (HP:0009778)1.96944966
136Rhabdomyosarcoma (HP:0002859)1.95649914
137Abnormality of the labia minora (HP:0012880)1.95479971
138Pulmonary fibrosis (HP:0002206)1.94740433
139Pancytopenia (HP:0001876)1.93368860
140Neoplasm of the pancreas (HP:0002894)1.93295520
141Abnormality of T cell physiology (HP:0011840)1.92907225
142Abnormality of reticulocytes (HP:0004312)1.91981397
143Recurrent bronchitis (HP:0002837)1.91653955
144Nephroblastoma (Wilms tumor) (HP:0002667)1.90609501
145Prominent nose (HP:0000448)1.90160210
146Hypercalciuria (HP:0002150)1.90146017
147Small for gestational age (HP:0001518)1.90055890
148Abnormality of the calcaneus (HP:0008364)1.89561100
149Abnormality of DNA repair (HP:0003254)1.88386774
150Muscular hypotonia of the trunk (HP:0008936)1.87927094
151Abnormality of the tricuspid valve (HP:0001702)1.87366772
152Abnormality of renin-angiotensin system (HP:0000847)1.86030157
153Hyperphosphaturia (HP:0003109)1.84131010
154Atresia of the external auditory canal (HP:0000413)1.83544578
155Severe combined immunodeficiency (HP:0004430)1.82179912
156Abnormality of pyrimidine metabolism (HP:0004353)1.81733155
157Hypophosphatemia (HP:0002148)1.81565959
158Agammaglobulinemia (HP:0004432)1.80932216
159Abnormality of the prostate (HP:0008775)1.80783026
160Retinal atrophy (HP:0001105)1.79977642
161Recurrent bacterial skin infections (HP:0005406)1.79734990
162Triphalangeal thumb (HP:0001199)1.79551210
163Aplasia/Hypoplasia of the sternum (HP:0006714)1.79134094
164Metaphyseal irregularity (HP:0003025)1.77368984
165Abnormal sex determination (HP:0012244)1.77024378
166Sex reversal (HP:0012245)1.77024378
167Hypercalcemia (HP:0003072)1.76548032
168Abnormality of the basal ganglia (HP:0002134)1.74593665
169Hypogonadotrophic hypogonadism (HP:0000044)1.68192298
170Wrist flexion contracture (HP:0001239)1.62455748
171Hypokalemia (HP:0002900)1.61990475
172Round ear (HP:0100830)1.61249122
173Tachypnea (HP:0002789)1.57848089
174Diminished movement (HP:0002374)1.57305224
175Testicular atrophy (HP:0000029)1.55450204
176Abnormal urine phosphate concentration (HP:0012599)1.55222451
177Abnormal drinking behavior (HP:0030082)1.54482897
178Polydipsia (HP:0001959)1.54482897
179Periodontitis (HP:0000704)1.49603612
180Transposition of the great arteries (HP:0001669)1.47872093
181Abnormal connection of the cardiac segments (HP:0011545)1.47872093
182Abnormal ventriculo-arterial connection (HP:0011563)1.47872093
183Macroorchidism (HP:0000053)1.45668384
184Atrioventricular canal defect (HP:0006695)1.44323718
185Zonular cataract (HP:0010920)1.43347845
186Abnormality of polysaccharide metabolism (HP:0011012)1.42630194
187Abnormality of glycosaminoglycan metabolism (HP:0004371)1.42630194
188Abnormality of mucopolysaccharide metabolism (HP:0011020)1.42630194
189Striae distensae (HP:0001065)1.41692283
190Progressive neurologic deterioration (HP:0002344)1.41419361
191Urinary glycosaminoglycan excretion (HP:0003541)1.40989157
192Mucopolysacchariduria (HP:0008155)1.40989157
193Postural tremor (HP:0002174)1.38274761
194Fetal akinesia sequence (HP:0001989)1.37326557
195Deformed sella turcica (HP:0002681)1.35560489
196Restlessness (HP:0000711)1.34584635
197Atelectasis (HP:0100750)1.29265256
198Mildly elevated creatine phosphokinase (HP:0008180)1.28834704
199Myoglobinuria (HP:0002913)1.28053031

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.93396413
2BUB14.79775685
3MAP3K14.54978856
4WEE14.14029726
5DAPK23.36259246
6EIF2AK13.29812686
7NTRK33.12891757
8NEK23.09383416
9HIPK23.00946869
10PLK42.70712085
11TTK2.51861568
12BRSK22.44953199
13ACVR1B2.37287618
14TESK22.35240820
15LMTK22.21735846
16NEK12.21539507
17BRSK12.16621078
18PLK12.13290324
19CCNB12.08554672
20SMG12.00085107
21UHMK11.97077171
22MAP4K11.96260103
23EIF2AK31.95229230
24STK101.93052660
25DAPK11.84749711
26SRPK11.83435712
27VRK11.83123323
28AURKB1.82606893
29ATR1.61982706
30STK41.58532234
31NME21.56896796
32STK161.53288535
33MAP3K81.53130466
34CDK71.38994592
35CHEK21.37258388
36DAPK31.35923476
37RPS6KA41.35561198
38AURKA1.34304378
39EPHA31.33880235
40CDK41.32688977
41PLK31.30740542
42IRAK21.29959892
43MAP2K61.29300080
44TLK11.24711481
45EEF2K1.24439605
46SIK11.22573094
47CLK11.20708581
48ERN11.17810879
49ICK1.11969785
50TSSK61.11750890
51CHEK11.07444645
52TESK11.06716746
53BLK1.02386943
54MKNK11.01687021
55RPS6KB21.00279903
56MAP3K90.99366163
57PASK0.99268730
58EPHB10.96887075
59DYRK1B0.96483427
60EIF2AK20.95633575
61ZAK0.90768616
62DYRK30.90149641
63CDK80.89842580
64PIM10.88736039
65ALK0.87587708
66PDGFRA0.86805432
67IRAK40.86450523
68BRAF0.85663350
69PBK0.84516109
70IRAK30.81689440
71MELK0.80965489
72CDK120.80110597
73FGFR40.79658956
74ATM0.78944158
75SCYL20.77599299
76PRPF4B0.77363805
77PRKCG0.76741096
78PIM20.76195877
79ZAP700.73719863
80LRRK20.70935892
81TXK0.70859919
82TRIB30.70712646
83PAK40.68561498
84CDK20.68548057
85KDR0.68500538
86NEK60.66303248
87MAP3K100.65206891
88TEC0.64090102
89CSF1R0.63894391
90PRKCH0.63811729
91BTK0.61752970
92MKNK20.61400308
93IRAK10.60785656
94SYK0.59795474
95MAP3K110.59772299
96PAK10.58642859
97NLK0.57584586
98TGFBR10.56810245
99CSNK2A10.55866129
100KIT0.55199553
101CDK10.54972133
102PRKD20.53019967
103TYK20.50481320
104STK30.50010535
105FGFR30.49433805
106CDK60.47346955
107GRK60.47085294
108FLT30.46989910
109LYN0.46649185
110PRKDC0.46356404
111MAP2K30.46135161
112LATS20.44495944
113NEK90.44276911
114PTK20.43988587
115PRKCI0.43952822
116CDK90.43553228
117MAP3K20.42826425
118ABL20.41375233
119JAK30.40548260
120RPS6KA50.40446349
121AKT20.39789423
122MAPK140.39231347
123CSNK2A20.38352678
124BRD40.37431584
125NTRK10.36641613
126ERBB30.36587112
127RAF10.36050138
128CAMK2D0.35683880
129MAP3K60.35463644
130MST40.35117763
131MAPKAPK30.34983509
132PTK60.34026900
133MOS0.33996940
134CDK50.31283009
135CDK140.30947505
136ARAF0.30408779
137CSNK1G30.29839039
138MAPK110.28384033
139CSNK1G10.26863006
140TAOK10.25618694
141MAPK90.25245958
142PKN20.24963051
143PRKAA10.24891910
144MAP3K50.24529127
145CDK11A0.24346444
146CDK30.24243341
147JAK10.24197717
148MAPK10.23931280
149MAPKAPK20.23817595
150CSNK1E0.23195793
151BMPR20.23195320
152FER0.23194016
153CDK150.22860336
154LIMK10.22725022
155RPS6KA60.22701559
156CDK180.22166931
157GSK3B0.22162823
158TRPM70.22053570
159MTOR0.20760972
160ROCK20.20265618
161PRKD30.19684577
162BCR0.15373855
163EPHA20.14963017

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.81148104
2Type II diabetes mellitus_Homo sapiens_hsa049304.95103943
3Mismatch repair_Homo sapiens_hsa034304.72286176
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.60506494
5Insulin secretion_Homo sapiens_hsa049113.59826053
6Base excision repair_Homo sapiens_hsa034103.57641924
7Homologous recombination_Homo sapiens_hsa034403.49519158
8Cell cycle_Homo sapiens_hsa041103.25078290
9Nucleotide excision repair_Homo sapiens_hsa034203.07209387
10Proteasome_Homo sapiens_hsa030502.96003986
11Type I diabetes mellitus_Homo sapiens_hsa049402.84997492
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82951677
13Spliceosome_Homo sapiens_hsa030402.72786973
14RNA transport_Homo sapiens_hsa030132.61214783
15RNA polymerase_Homo sapiens_hsa030202.60590042
16Ribosome_Homo sapiens_hsa030102.58141915
17Pyrimidine metabolism_Homo sapiens_hsa002402.47838393
18Fanconi anemia pathway_Homo sapiens_hsa034602.45507668
19Non-homologous end-joining_Homo sapiens_hsa034502.43406384
20Butanoate metabolism_Homo sapiens_hsa006502.33878576
21One carbon pool by folate_Homo sapiens_hsa006702.20955691
22Maturity onset diabetes of the young_Homo sapiens_hsa0495010.6865314
23RNA degradation_Homo sapiens_hsa030181.89976281
24Basal transcription factors_Homo sapiens_hsa030221.87852065
25p53 signaling pathway_Homo sapiens_hsa041151.87099228
26Vibrio cholerae infection_Homo sapiens_hsa051101.79090728
27Galactose metabolism_Homo sapiens_hsa000521.64919281
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62189788
29Primary immunodeficiency_Homo sapiens_hsa053401.40899989
30mRNA surveillance pathway_Homo sapiens_hsa030151.38632626
31Systemic lupus erythematosus_Homo sapiens_hsa053221.34426454
32Antigen processing and presentation_Homo sapiens_hsa046121.26405207
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25340268
34Purine metabolism_Homo sapiens_hsa002301.24500641
35Sphingolipid metabolism_Homo sapiens_hsa006001.24441291
36Synaptic vesicle cycle_Homo sapiens_hsa047211.24382147
37Fatty acid elongation_Homo sapiens_hsa000621.23417431
38Glucagon signaling pathway_Homo sapiens_hsa049221.22230653
39Oocyte meiosis_Homo sapiens_hsa041141.19601345
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15234020
41Herpes simplex infection_Homo sapiens_hsa051681.11750703
42Epstein-Barr virus infection_Homo sapiens_hsa051691.11487519
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01901968
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01229857
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98167499
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97559577
47Viral carcinogenesis_Homo sapiens_hsa052030.97061336
48beta-Alanine metabolism_Homo sapiens_hsa004100.96996489
49Lysosome_Homo sapiens_hsa041420.93095101
50Pentose phosphate pathway_Homo sapiens_hsa000300.90954593
51Sulfur metabolism_Homo sapiens_hsa009200.90432852
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87630397
53ABC transporters_Homo sapiens_hsa020100.86459351
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.85990744
55Circadian rhythm_Homo sapiens_hsa047100.80376673
56Vitamin B6 metabolism_Homo sapiens_hsa007500.78555733
57HTLV-I infection_Homo sapiens_hsa051660.78064244
58Amphetamine addiction_Homo sapiens_hsa050310.71282992
59Graft-versus-host disease_Homo sapiens_hsa053320.70404257
60Renin secretion_Homo sapiens_hsa049240.68632221
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.65751194
62Measles_Homo sapiens_hsa051620.65001534
63Legionellosis_Homo sapiens_hsa051340.64514097
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.64180375
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63507829
66Apoptosis_Homo sapiens_hsa042100.63356756
67Shigellosis_Homo sapiens_hsa051310.63068881
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62237626
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.61904377
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59145552
71Protein export_Homo sapiens_hsa030600.58381728
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56873932
73Small cell lung cancer_Homo sapiens_hsa052220.56752283
74Hematopoietic cell lineage_Homo sapiens_hsa046400.56205297
75Hepatitis B_Homo sapiens_hsa051610.55942620
76Fatty acid metabolism_Homo sapiens_hsa012120.54064251
77Folate biosynthesis_Homo sapiens_hsa007900.54029284
78Leishmaniasis_Homo sapiens_hsa051400.53138870
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.52034049
80MicroRNAs in cancer_Homo sapiens_hsa052060.51524214
81Cocaine addiction_Homo sapiens_hsa050300.50154985
82Biosynthesis of amino acids_Homo sapiens_hsa012300.49422608
83Glutathione metabolism_Homo sapiens_hsa004800.48369971
84Collecting duct acid secretion_Homo sapiens_hsa049660.47939861
85Allograft rejection_Homo sapiens_hsa053300.47048407
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.47011787
87B cell receptor signaling pathway_Homo sapiens_hsa046620.45592696
88Viral myocarditis_Homo sapiens_hsa054160.44807583
89Thyroid cancer_Homo sapiens_hsa052160.44175371
90Prolactin signaling pathway_Homo sapiens_hsa049170.44025412
91Circadian entrainment_Homo sapiens_hsa047130.43914163
92Selenocompound metabolism_Homo sapiens_hsa004500.43749064
93Huntingtons disease_Homo sapiens_hsa050160.43430288
94Influenza A_Homo sapiens_hsa051640.42591129
95Pancreatic cancer_Homo sapiens_hsa052120.42298269
96Long-term depression_Homo sapiens_hsa047300.39875479
97Alcoholism_Homo sapiens_hsa050340.39583898
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39194317
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37905819
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37853820
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.36995613
102Thyroid hormone synthesis_Homo sapiens_hsa049180.36634304
103Insulin signaling pathway_Homo sapiens_hsa049100.36592241
104Colorectal cancer_Homo sapiens_hsa052100.36067324
105Starch and sucrose metabolism_Homo sapiens_hsa005000.34094495
106Gap junction_Homo sapiens_hsa045400.33997417
107N-Glycan biosynthesis_Homo sapiens_hsa005100.33512915
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32996348
109GABAergic synapse_Homo sapiens_hsa047270.32648254
110AMPK signaling pathway_Homo sapiens_hsa041520.32392134
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31681073
112Inositol phosphate metabolism_Homo sapiens_hsa005620.30927249
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29438317
114Chronic myeloid leukemia_Homo sapiens_hsa052200.28150309
115Dopaminergic synapse_Homo sapiens_hsa047280.27359331
116Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26718728
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26468723
118Insulin resistance_Homo sapiens_hsa049310.26102688
119Carbon metabolism_Homo sapiens_hsa012000.26079384
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26071039
121Melanogenesis_Homo sapiens_hsa049160.25758261
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24783504
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23243213
124Regulation of autophagy_Homo sapiens_hsa041400.23181001
125Asthma_Homo sapiens_hsa053100.23165641
126Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23157876
127Parkinsons disease_Homo sapiens_hsa050120.23121834
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22841007
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22417403
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.21426912
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21298375
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21177158
133Long-term potentiation_Homo sapiens_hsa047200.20738634
134mTOR signaling pathway_Homo sapiens_hsa041500.20021516
135TGF-beta signaling pathway_Homo sapiens_hsa043500.19455616
136Pancreatic secretion_Homo sapiens_hsa049720.19249831
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19075562
138T cell receptor signaling pathway_Homo sapiens_hsa046600.18179999
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17884260
140Ovarian steroidogenesis_Homo sapiens_hsa049130.17608757
141Prostate cancer_Homo sapiens_hsa052150.17309182
142Dilated cardiomyopathy_Homo sapiens_hsa054140.17268166
143Non-small cell lung cancer_Homo sapiens_hsa052230.16363289
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16212021
145Gastric acid secretion_Homo sapiens_hsa049710.15856362
146Protein digestion and absorption_Homo sapiens_hsa049740.15394733
147Renin-angiotensin system_Homo sapiens_hsa046140.14802853
148GnRH signaling pathway_Homo sapiens_hsa049120.14801331
149Bladder cancer_Homo sapiens_hsa052190.14449143
150Estrogen signaling pathway_Homo sapiens_hsa049150.14349023
151cGMP-PKG signaling pathway_Homo sapiens_hsa040220.14259004
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.14116285
153Other glycan degradation_Homo sapiens_hsa005110.13647150
154SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13345467
155Jak-STAT signaling pathway_Homo sapiens_hsa046300.13312419
156Toxoplasmosis_Homo sapiens_hsa051450.12887762
157Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12737701
158Arachidonic acid metabolism_Homo sapiens_hsa005900.11340804
159Sulfur relay system_Homo sapiens_hsa041220.10961280
160Metabolic pathways_Homo sapiens_hsa011000.10702353
161Autoimmune thyroid disease_Homo sapiens_hsa053200.10408079
162Salmonella infection_Homo sapiens_hsa051320.09994123
163Tuberculosis_Homo sapiens_hsa051520.09908324
164cAMP signaling pathway_Homo sapiens_hsa040240.09581942
165Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.09115208

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