ASIC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)8.42491119
2detection of light stimulus involved in sensory perception (GO:0050962)8.35052976
3detection of light stimulus involved in visual perception (GO:0050908)8.35052976
4negative regulation of cytosolic calcium ion concentration (GO:0051481)7.05924298
5cellular potassium ion homeostasis (GO:0030007)6.75856993
6urinary tract smooth muscle contraction (GO:0014848)6.20683911
7sodium ion export (GO:0071436)5.72998658
8neurofilament cytoskeleton organization (GO:0060052)5.61678962
9relaxation of smooth muscle (GO:0044557)5.56652234
10potassium ion homeostasis (GO:0055075)5.56057595
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.55108911
12synaptic vesicle exocytosis (GO:0016079)5.30072107
13cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.28537414
14* detection of temperature stimulus (GO:0016048)5.27919377
15retinal rod cell development (GO:0046548)5.17357300
16retinal cone cell development (GO:0046549)5.05459364
17G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.78547813
18* detection of temperature stimulus involved in sensory perception (GO:0050961)4.74501734
19* detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.74501734
20innervation (GO:0060384)4.70617444
21regulation of synaptic vesicle exocytosis (GO:2000300)4.57914885
22cell communication by electrical coupling (GO:0010644)4.53572593
23positive regulation of synapse maturation (GO:0090129)4.50436897
24postsynaptic membrane organization (GO:0001941)4.48490510
25membrane depolarization during action potential (GO:0086010)4.44918417
26regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.41895113
27peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.40503735
28neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.35260368
29protein localization to synapse (GO:0035418)4.31330293
30cell migration in hindbrain (GO:0021535)4.30818917
31axon cargo transport (GO:0008088)4.27074517
32synaptic vesicle maturation (GO:0016188)4.20320626
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.18579434
34regulation of synapse structural plasticity (GO:0051823)4.17447093
35cell-cell junction maintenance (GO:0045217)4.12354276
36potassium ion export (GO:0071435)4.06577260
37neuronal ion channel clustering (GO:0045161)4.05451691
38gamma-aminobutyric acid signaling pathway (GO:0007214)4.01693255
39synaptic vesicle endocytosis (GO:0048488)4.00711083
40regulation of short-term neuronal synaptic plasticity (GO:0048172)4.00495878
41establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.86170852
42mitochondrion transport along microtubule (GO:0047497)3.86170852
43cellular sodium ion homeostasis (GO:0006883)3.85715975
44rhodopsin mediated signaling pathway (GO:0016056)3.80539670
45regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.80306890
46regulation of glycogen (starch) synthase activity (GO:2000465)3.79548751
47establishment of mitochondrion localization (GO:0051654)3.77498103
48positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.74635475
49locomotory exploration behavior (GO:0035641)3.72237406
50regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.69457919
51regulation of ARF protein signal transduction (GO:0032012)3.65827644
52regulation of synaptic vesicle transport (GO:1902803)3.63863333
53cell communication involved in cardiac conduction (GO:0086065)3.59899741
54neuronal action potential (GO:0019228)3.59703534
55regulation of ARF GTPase activity (GO:0032312)3.59371677
56regulation of glucocorticoid secretion (GO:2000849)3.59212127
57protein-chromophore linkage (GO:0018298)3.57688352
58membrane hyperpolarization (GO:0060081)3.56247513
59negative regulation of smooth muscle contraction (GO:0045986)3.53595114
60axonal fasciculation (GO:0007413)3.53161730
61glutamate secretion (GO:0014047)3.48787054
62cerebellar granule cell differentiation (GO:0021707)3.47987862
63positive regulation of potassium ion transmembrane transport (GO:1901381)3.45911809
64ionotropic glutamate receptor signaling pathway (GO:0035235)3.42041934
65negative regulation of calcium ion transport into cytosol (GO:0010523)3.41126857
66positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.40286610
67anterograde axon cargo transport (GO:0008089)3.39289118
68gonadal mesoderm development (GO:0007506)3.39111433
69regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.38749509
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.32131537
71positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31838467
72exploration behavior (GO:0035640)3.31821937
73retinal ganglion cell axon guidance (GO:0031290)3.31308569
74photoreceptor cell development (GO:0042461)3.28403679
75membrane repolarization (GO:0086009)3.27804077
76regulation of synapse maturation (GO:0090128)3.26636592
77regulation of rhodopsin mediated signaling pathway (GO:0022400)3.25453596
78histone H3 deacetylation (GO:0070932)3.24179326
79sex determination (GO:0007530)3.23826977
80neuron recognition (GO:0008038)3.23379773
81eye photoreceptor cell development (GO:0042462)3.22340743
82axon ensheathment in central nervous system (GO:0032291)3.21231897
83central nervous system myelination (GO:0022010)3.21231897
84mating behavior (GO:0007617)3.20776471
85regulation of voltage-gated calcium channel activity (GO:1901385)3.19556165
86neuromuscular process controlling posture (GO:0050884)3.18994207
87tachykinin receptor signaling pathway (GO:0007217)3.18972030
88cell junction maintenance (GO:0034331)3.18418009
89neuron cell-cell adhesion (GO:0007158)3.17527654
90neuronal action potential propagation (GO:0019227)3.17504314
91respiratory system process (GO:0003016)3.14962791
92cytoplasmic sequestering of transcription factor (GO:0042994)3.13039250
93regulation of neuronal synaptic plasticity (GO:0048168)3.12672857
94ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.12259687
95negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11646387
96regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.11578844
97regulation of corticosteroid hormone secretion (GO:2000846)3.10196691
98regulation of membrane repolarization (GO:0060306)3.07585349
99cellular potassium ion transport (GO:0071804)3.07458029
100potassium ion transmembrane transport (GO:0071805)3.07458029
101synaptic vesicle transport (GO:0048489)3.06604179
102establishment of synaptic vesicle localization (GO:0097480)3.06604179
103positive regulation of TOR signaling (GO:0032008)3.05842480
104regulation of respiratory system process (GO:0044065)3.04147697
105synaptic transmission, glutamatergic (GO:0035249)3.03475348
106neurotransmitter catabolic process (GO:0042135)3.02694357
107axon extension (GO:0048675)3.02160349
108GMP metabolic process (GO:0046037)3.00374629
109positive regulation of protein kinase C signaling (GO:0090037)2.98344995
110positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.97579424
111striatum development (GO:0021756)2.97564187
112negative regulation of cation channel activity (GO:2001258)2.97021451
113regulation of glutamate receptor signaling pathway (GO:1900449)2.96098320
114regulation of respiratory gaseous exchange (GO:0043576)2.95677150
115sodium ion homeostasis (GO:0055078)2.95458442
116vocalization behavior (GO:0071625)2.95350673
117peripheral nervous system neuron development (GO:0048935)2.92779890
118synapse assembly (GO:0007416)2.92548775
119behavioral response to ethanol (GO:0048149)2.91917370
120layer formation in cerebral cortex (GO:0021819)2.90734168
121axon development (GO:0061564)2.90563839
122neuromuscular process controlling balance (GO:0050885)2.89845948
123negative regulation of dendrite morphogenesis (GO:0050774)2.89042332
124neurotransmitter secretion (GO:0007269)2.88127164
125histone H4 deacetylation (GO:0070933)2.86690098
126regulation of synaptic transmission, glutamatergic (GO:0051966)2.86170257
127cerebral cortex radially oriented cell migration (GO:0021799)2.85667122
128dopamine receptor signaling pathway (GO:0007212)2.85571056
129regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.83630791
130neuromuscular synaptic transmission (GO:0007274)2.83403385
131positive regulation of dendritic spine development (GO:0060999)2.83078554
132calcium ion import (GO:0070509)2.82255093
133potassium ion transport (GO:0006813)2.81545226
134neuron projection extension (GO:1990138)2.78238881
135cerebellar Purkinje cell differentiation (GO:0021702)2.78178094
136dendritic spine morphogenesis (GO:0060997)2.77329476
137regulation of neurotransmitter secretion (GO:0046928)2.75837556
138pyrimidine nucleobase catabolic process (GO:0006208)2.75459433
139positive regulation of membrane potential (GO:0045838)2.75426792
140action potential (GO:0001508)2.75131087
141regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.74798148
142neurotransmitter transport (GO:0006836)2.74599114
143positive regulation of potassium ion transport (GO:0043268)2.73079272
144microtubule-based transport (GO:0010970)2.71758137
145behavioral response to nicotine (GO:0035095)2.70221078
146G-protein coupled receptor internalization (GO:0002031)2.70124087
147positive regulation of dendrite development (GO:1900006)2.70066926
148positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.69751044
149adult walking behavior (GO:0007628)2.69656278
150negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.68960033
151response to parathyroid hormone (GO:0071107)2.67997848
152regulation of synaptic plasticity (GO:0048167)2.67932965
153peristalsis (GO:0030432)2.67357930
154negative regulation of axonogenesis (GO:0050771)2.65675351
155positive regulation of CREB transcription factor activity (GO:0032793)2.64872772
156positive regulation of neurotransmitter transport (GO:0051590)2.64866645
157negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.64358708
158autophagic vacuole assembly (GO:0000045)2.63669680
159peptidyl-tyrosine autophosphorylation (GO:0038083)2.62001106
160mitochondrion localization (GO:0051646)2.61224088
161calcium ion-dependent exocytosis (GO:0017156)2.60800223
162adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.57843472
163negative regulation of catenin import into nucleus (GO:0035414)2.57095068
164regulation of excitatory postsynaptic membrane potential (GO:0060079)2.56546922
165cell differentiation in hindbrain (GO:0021533)2.56514143
166regulation of postsynaptic membrane potential (GO:0060078)2.56010194
167G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.55788564
168L-amino acid import (GO:0043092)2.52403038
169long-term memory (GO:0007616)2.52109327
170cellular component maintenance (GO:0043954)2.51493262
171male sex determination (GO:0030238)2.50940181

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.44416404
2GBX2_23144817_ChIP-Seq_PC3_Human3.43631149
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.04322504
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.01980821
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84437922
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.81008941
7LXR_22292898_ChIP-Seq_THP-1_Human2.76438131
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76376952
9REST_21632747_ChIP-Seq_MESCs_Mouse2.71502161
10AR_21572438_ChIP-Seq_LNCaP_Human2.71005632
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.67645813
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.60657023
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.59237732
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55969991
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48415121
16ERG_21242973_ChIP-ChIP_JURKAT_Human2.44228935
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43828993
18TAF15_26573619_Chip-Seq_HEK293_Human2.37255834
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.37187294
20P68_20966046_ChIP-Seq_HELA_Human2.36182885
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35837463
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35837463
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31455588
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.25989802
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.24708091
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.22995640
27KDM2B_26808549_Chip-Seq_SUP-B15_Human2.15688620
28EZH2_27304074_Chip-Seq_ESCs_Mouse2.09450165
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.08533217
30ZFP281_18757296_ChIP-ChIP_E14_Mouse2.06062581
31VDR_22108803_ChIP-Seq_LS180_Human2.04572863
32KDM2B_26808549_Chip-Seq_DND41_Human2.02162509
33SMC4_20622854_ChIP-Seq_HELA_Human2.00356305
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00064270
35P53_22127205_ChIP-Seq_FIBROBLAST_Human1.94228452
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93852247
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.92404167
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90892850
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89413326
40IGF1R_20145208_ChIP-Seq_DFB_Human1.88848193
41DROSHA_22980978_ChIP-Seq_HELA_Human1.88716035
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88061849
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85999406
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81282711
45VDR_21846776_ChIP-Seq_THP-1_Human1.80275853
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75135600
47SMAD4_21799915_ChIP-Seq_A2780_Human1.72211791
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71779082
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.70052004
50CREB1_26743006_Chip-Seq_LNCaP_Human1.68051310
51MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.66295172
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63409620
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62088787
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.62017959
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60413540
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.60398824
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.59966674
58SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.59371687
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58563513
60CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.55539700
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50206828
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.50067501
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49402103
64PHF8_20622854_ChIP-Seq_HELA_Human1.49059565
65EZH2_22144423_ChIP-Seq_EOC_Human1.48835326
66RACK7_27058665_Chip-Seq_MCF-7_Human1.48658996
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47967739
68BCL6_27268052_Chip-Seq_Bcells_Human1.47939742
69BCOR_27268052_Chip-Seq_Bcells_Human1.46851375
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46159222
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.45537375
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44646354
73OCT4_19829295_ChIP-Seq_ESCs_Human1.43355883
74AR_25329375_ChIP-Seq_VCAP_Human1.37149955
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36977746
76E2F1_20622854_ChIP-Seq_HELA_Human1.36835144
77TCF7_22412390_ChIP-Seq_EML_Mouse1.36713139
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36209808
79CTCF_27219007_Chip-Seq_Bcells_Human1.35869082
80TET1_21490601_ChIP-Seq_MESCs_Mouse1.35724373
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.33277751
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32644093
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32286247
84RNF2_27304074_Chip-Seq_NSC_Mouse1.30075081
85P300_19829295_ChIP-Seq_ESCs_Human1.28473646
86TP63_22573176_ChIP-Seq_HFKS_Human1.27763751
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.26343965
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25501612
89AR_19668381_ChIP-Seq_PC3_Human1.25118927
90STAT3_23295773_ChIP-Seq_U87_Human1.24221465
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.23314645
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23256303
93CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22655389
94SMAD3_21741376_ChIP-Seq_HESCs_Human1.21378616
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21026100
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21015555
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20421219
98FOXP1_21924763_ChIP-Seq_HESCs_Human1.20185358
99SMAD4_21741376_ChIP-Seq_HESCs_Human1.20168726
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20140977
101SA1_27219007_Chip-Seq_Bcells_Human1.18491522
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18476250
103TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.18350118
104RARB_24833708_ChIP-Seq_LIVER_Mouse1.17843542
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17493269
106OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17468255
107CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16844340
108TP53_23651856_ChIP-Seq_MEFs_Mouse1.15298881
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15202320
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14647490
111RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14356315
112SOX2_21211035_ChIP-Seq_LN229_Gbm1.13507508
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12563626
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11933609
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11806057
116ESR2_21235772_ChIP-Seq_MCF-7_Human1.11569770
117RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10798320
118STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.10736652
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09629292
120CTCF_20526341_ChIP-Seq_ESCs_Human1.09329536
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08844769
122MAF_26560356_Chip-Seq_TH2_Human1.08388408
123CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07736471
124KDM2B_26808549_Chip-Seq_K562_Human1.07665057
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07373702
126SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.06570209
127RARA_24833708_ChIP-Seq_LIVER_Mouse1.06221122
128SMAD3_21741376_ChIP-Seq_EPCs_Human1.04405042
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04381946
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03935121
131SMAD3_21741376_ChIP-Seq_ESCs_Human1.03233048
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02971169
133DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02642197
134SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02388158
135FLI1_21867929_ChIP-Seq_TH2_Mouse1.02185646
136TP53_22127205_ChIP-Seq_IMR90_Human1.01619135
137YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01559920
138SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00905932
139ZNF274_21170338_ChIP-Seq_K562_Hela1.00884452
140MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00779788
141CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00369923
142SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00336097
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99854423
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98672806
145RING1B_27294783_Chip-Seq_NPCs_Mouse0.97616197
146NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.96912167
147ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95967472
148EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94927529
149CBX2_27304074_Chip-Seq_ESCs_Mouse0.94667158
150PRDM14_20953172_ChIP-Seq_ESCs_Human0.93113248
151TCF4_23295773_ChIP-Seq_U87_Human0.92015211
152AHR_22903824_ChIP-Seq_MCF-7_Human0.90685014
153TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88893392
154TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88303022
155TP53_20018659_ChIP-ChIP_R1E_Mouse0.87684090
156SMAD_19615063_ChIP-ChIP_OVARY_Human0.87267042
157SMAD4_21741376_ChIP-Seq_EPCs_Human0.86583940
158BCAT_22108803_ChIP-Seq_LS180_Human0.86086656
159OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85085216
160CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84660612
161ESR1_20079471_ChIP-ChIP_T-47D_Human0.84277665
162ARNT_22903824_ChIP-Seq_MCF-7_Human0.83699565

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception5.73437772
2MP0005551_abnormal_eye_electrophysiolog4.66541507
3MP0001968_abnormal_touch/_nociception3.99303407
4MP0006276_abnormal_autonomic_nervous3.83957763
5MP0004270_analgesia3.50802143
6MP0002736_abnormal_nociception_after3.29688707
7MP0004858_abnormal_nervous_system3.27993777
8MP0002734_abnormal_mechanical_nocicepti3.12952063
9MP0001984_abnormal_olfaction3.08012798
10MP0002090_abnormal_vision3.05402490
11MP0006072_abnormal_retinal_apoptosis2.88423517
12MP0003123_paternal_imprinting2.52320457
13MP0001986_abnormal_taste_sensitivity2.49250734
14MP0001502_abnormal_circadian_rhythm2.44089977
15MP0002272_abnormal_nervous_system2.40196721
16MP0009046_muscle_twitch2.32559181
17MP0002184_abnormal_innervation2.31303876
18MP0003787_abnormal_imprinting2.31028534
19MP0001970_abnormal_pain_threshold2.27202794
20MP0005253_abnormal_eye_physiology2.23398194
21MP0004233_abnormal_muscle_weight2.21468487
22MP0002067_abnormal_sensory_capabilities2.19968895
23MP0003880_abnormal_central_pattern2.18586684
24MP0001188_hyperpigmentation2.16031179
25MP0002733_abnormal_thermal_nociception2.09267302
26MP0000678_abnormal_parathyroid_gland2.00567468
27MP0002638_abnormal_pupillary_reflex1.99328814
28MP0001346_abnormal_lacrimal_gland1.92244447
29MP0003635_abnormal_synaptic_transmissio1.91425439
30MP0004859_abnormal_synaptic_plasticity1.91253684
31MP0010386_abnormal_urinary_bladder1.90015849
32MP0002229_neurodegeneration1.88411640
33MP0005409_darkened_coat_color1.87864372
34MP0003283_abnormal_digestive_organ1.87831297
35MP0002653_abnormal_ependyma_morphology1.85299441
36MP0003122_maternal_imprinting1.84421527
37MP0005195_abnormal_posterior_eye1.75794799
38MP0003879_abnormal_hair_cell1.73080793
39MP0000751_myopathy1.70635837
40MP0002249_abnormal_larynx_morphology1.68880716
41MP0001486_abnormal_startle_reflex1.68172401
42MP0003136_yellow_coat_color1.67942390
43MP0002752_abnormal_somatic_nervous1.67804795
44MP0008775_abnormal_heart_ventricle1.65127695
45MP0004036_abnormal_muscle_relaxation1.64849193
46MP0002751_abnormal_autonomic_nervous1.64299517
47MP0002063_abnormal_learning/memory/cond1.62946054
48MP0005423_abnormal_somatic_nervous1.59840742
49MP0002064_seizures1.58887602
50MP0002882_abnormal_neuron_morphology1.48030640
51MP0009745_abnormal_behavioral_response1.46003683
52MP0009780_abnormal_chondrocyte_physiolo1.42428705
53MP0002909_abnormal_adrenal_gland1.41807834
54MP0003121_genomic_imprinting1.41237717
55MP0000955_abnormal_spinal_cord1.37820387
56MP0004811_abnormal_neuron_physiology1.35552239
57MP0004145_abnormal_muscle_electrophysio1.31630522
58MP0002572_abnormal_emotion/affect_behav1.30974777
59MP0008569_lethality_at_weaning1.29126954
60MP0000534_abnormal_ureter_morphology1.27660600
61MP0003011_delayed_dark_adaptation1.23412519
62MP0003329_amyloid_beta_deposits1.23194189
63MP0004130_abnormal_muscle_cell1.22153223
64MP0004782_abnormal_surfactant_physiolog1.21950149
65MP0004084_abnormal_cardiac_muscle1.20567137
66MP0003950_abnormal_plasma_membrane1.18535255
67MP0004142_abnormal_muscle_tone1.18373628
68MP0000015_abnormal_ear_pigmentation1.17389618
69MP0002152_abnormal_brain_morphology1.15336904
70MP0001348_abnormal_lacrimal_gland1.14523649
71MP0004215_abnormal_myocardial_fiber1.12253909
72MP0003634_abnormal_glial_cell1.11367621
73MP0003172_abnormal_lysosome_physiology1.10543162
74MP0001905_abnormal_dopamine_level1.05953174
75MP0008995_early_reproductive_senescence1.05658180
76MP0005646_abnormal_pituitary_gland1.03496732
77MP0005248_abnormal_Harderian_gland0.99836754
78MP0000372_irregular_coat_pigmentation0.98620364
79MP0003633_abnormal_nervous_system0.96668307
80MP0005174_abnormal_tail_pigmentation0.93971282
81MP0002822_catalepsy0.93826384
82MP0004147_increased_porphyrin_level0.92336519
83MP0008260_abnormal_autophagy0.91549124
84MP0002332_abnormal_exercise_endurance0.90847408
85MP0003690_abnormal_glial_cell0.89495346
86MP0002066_abnormal_motor_capabilities/c0.88902226
87MP0001963_abnormal_hearing_physiology0.88292200
88MP0004085_abnormal_heartbeat0.86739416
89MP0009379_abnormal_foot_pigmentation0.86291629
90MP0001270_distended_abdomen0.85541343
91MP0000749_muscle_degeneration0.85338638
92MP0005386_behavior/neurological_phenoty0.85019498
93MP0004924_abnormal_behavior0.85019498
94MP0005595_abnormal_vascular_smooth0.83306004
95MP0002089_abnormal_postnatal_growth/wei0.82906921
96MP0003137_abnormal_impulse_conducting0.82873333
97MP0005394_taste/olfaction_phenotype0.82267630
98MP0005499_abnormal_olfactory_system0.82267630
99MP0001501_abnormal_sleep_pattern0.82198095
100MP0000604_amyloidosis0.81596049
101MP0004742_abnormal_vestibular_system0.80156216
102MP0005535_abnormal_body_temperature0.80150243
103MP0002557_abnormal_social/conspecific_i0.79897910
104MP0000566_synostosis0.79509572
105MP0003632_abnormal_nervous_system0.77113442
106MP0003861_abnormal_nervous_system0.76451471
107MP0000681_abnormal_thyroid_gland0.75916504
108MP0004133_heterotaxia0.74961422
109MP0001324_abnormal_eye_pigmentation0.74552722
110MP0005670_abnormal_white_adipose0.73669254
111MP0000920_abnormal_myelination0.73564091
112MP0002108_abnormal_muscle_morphology0.72294054
113MP0003868_abnormal_feces_composition0.72086169
114MP0000049_abnormal_middle_ear0.70397283
115MP0000631_abnormal_neuroendocrine_gland0.70189052
116MP0003942_abnormal_urinary_system0.69157637
117MP0001529_abnormal_vocalization0.68947736
118MP0009697_abnormal_copulation0.68631604
119MP0008874_decreased_physiological_sensi0.68556910
120MP0003631_nervous_system_phenotype0.68471453
121MP0005620_abnormal_muscle_contractility0.66120321
122MP0010030_abnormal_orbit_morphology0.65925135
123MP0000003_abnormal_adipose_tissue0.65637174
124MP0002269_muscular_atrophy0.65484132
125MP0005058_abnormal_lysosome_morphology0.64952202
126MP0005391_vision/eye_phenotype0.62259914
127MP0004510_myositis0.61619726
128MP0002116_abnormal_craniofacial_bone0.61024502
129MP0004885_abnormal_endolymph0.59523658
130MP0000013_abnormal_adipose_tissue0.59408256
131MP0010769_abnormal_survival0.59161496
132MP0006292_abnormal_olfactory_placode0.58814119
133MP0000026_abnormal_inner_ear0.57434844
134MP0000230_abnormal_systemic_arterial0.57353946
135MP0000778_abnormal_nervous_system0.57166852
136MP0004134_abnormal_chest_morphology0.56579405
137MP0002234_abnormal_pharynx_morphology0.56343942
138MP0010368_abnormal_lymphatic_system0.54517935
139MP0000747_muscle_weakness0.53120169
140MP0002069_abnormal_eating/drinking_beha0.53027554
141MP0001440_abnormal_grooming_behavior0.52762211

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)6.42861334
2Severe visual impairment (HP:0001141)5.69859374
3Ulnar claw (HP:0001178)5.42311605
4Abnormality of macular pigmentation (HP:0008002)5.41188240
5Febrile seizures (HP:0002373)5.18413748
6Abnormal rod and cone electroretinograms (HP:0008323)5.06212611
7Epileptic encephalopathy (HP:0200134)4.59332428
8Action tremor (HP:0002345)4.37279512
9Absence seizures (HP:0002121)4.34894166
10Keratoconus (HP:0000563)4.29305146
11Increased corneal curvature (HP:0100692)4.29305146
12Myokymia (HP:0002411)4.27394925
13Scotoma (HP:0000575)4.20292268
14Annular pancreas (HP:0001734)4.01287798
15Septo-optic dysplasia (HP:0100842)3.97291019
16Decreased central vision (HP:0007663)3.89029652
17Bony spicule pigmentary retinopathy (HP:0007737)3.70324162
18Dialeptic seizures (HP:0011146)3.56697867
19Abnormal gallbladder physiology (HP:0012438)3.54302444
20Cholecystitis (HP:0001082)3.54302444
21Neurofibrillary tangles (HP:0002185)3.42415142
22Peripheral hypomyelination (HP:0007182)3.32912296
23Obstructive sleep apnea (HP:0002870)3.31847123
24Turricephaly (HP:0000262)3.17505163
25Thin bony cortex (HP:0002753)3.14262926
26Abnormal pupillary function (HP:0007686)3.10679320
27Absent rod-and cone-mediated responses on ERG (HP:0007688)3.10134063
28Sleep apnea (HP:0010535)3.08688432
29Rib fusion (HP:0000902)3.07785909
30Progressive cerebellar ataxia (HP:0002073)3.02634796
31Retinal dysplasia (HP:0007973)2.97416028
32Supranuclear gaze palsy (HP:0000605)2.93178136
33Papilledema (HP:0001085)2.90910751
34Spinal canal stenosis (HP:0003416)2.86664288
35Amblyopia (HP:0000646)2.86295471
36Truncus arteriosus (HP:0001660)2.83253370
37Hyperthyroidism (HP:0000836)2.79942917
38Abnormality of pain sensation (HP:0010832)2.79000664
39Impaired pain sensation (HP:0007328)2.79000664
40Prolonged QT interval (HP:0001657)2.72980942
41Segmental peripheral demyelination/remyelination (HP:0003481)2.70415915
42Hammertoe (HP:0001765)2.68868842
43Akinesia (HP:0002304)2.68789976
44Termporal pattern (HP:0011008)2.68132114
45Insidious onset (HP:0003587)2.68132114
46Broad face (HP:0000283)2.65513826
47Onion bulb formation (HP:0003383)2.65503782
48Steppage gait (HP:0003376)2.62373765
49Focal seizures (HP:0007359)2.61880621
50Atonic seizures (HP:0010819)2.59213474
51J-shaped sella turcica (HP:0002680)2.56231073
52Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.55524840
53Generalized tonic-clonic seizures (HP:0002069)2.52655148
54Cerebral hypomyelination (HP:0006808)2.52594280
55Abnormal number of incisors (HP:0011064)2.51156394
56EEG with generalized epileptiform discharges (HP:0011198)2.47304881
57Foot dorsiflexor weakness (HP:0009027)2.46220388
58Cerebral inclusion bodies (HP:0100314)2.44352815
59Neuronal loss in central nervous system (HP:0002529)2.44200412
60Hypoplasia of the fovea (HP:0007750)2.43912253
61Aplasia/Hypoplasia of the fovea (HP:0008060)2.43912253
62Ventricular fibrillation (HP:0001663)2.43214255
63Pointed chin (HP:0000307)2.40787459
64Abnormality of the corticospinal tract (HP:0002492)2.39432859
65Focal motor seizures (HP:0011153)2.38309400
66Reticulocytosis (HP:0001923)2.37993597
67Epileptiform EEG discharges (HP:0011182)2.34300660
68Diplopia (HP:0000651)2.32910567
69Abnormality of binocular vision (HP:0011514)2.32910567
70Male infertility (HP:0003251)2.32074971
71Dyschromatopsia (HP:0007641)2.31624295
72Hemiparesis (HP:0001269)2.29947396
73Hypoventilation (HP:0002791)2.28206321
74Pheochromocytoma (HP:0002666)2.26672077
75Cone-rod dystrophy (HP:0000548)2.26062902
76Dysautonomia (HP:0002459)2.25304590
77Ankle clonus (HP:0011448)2.23223015
78Decreased motor nerve conduction velocity (HP:0003431)2.23059272
79Optic nerve hypoplasia (HP:0000609)2.22837195
80Abnormality of the foot musculature (HP:0001436)2.20956596
81Hand muscle atrophy (HP:0009130)2.19865596
82Neuroendocrine neoplasm (HP:0100634)2.19501751
83Stereotypic behavior (HP:0000733)2.18339699
84Depression (HP:0000716)2.14698395
85Limb dystonia (HP:0002451)2.13191473
86Spastic gait (HP:0002064)2.12210650
87Degeneration of the lateral corticospinal tracts (HP:0002314)2.09386420
88Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.09386420
89Double outlet right ventricle (HP:0001719)2.06368935
90Congenital malformation of the right heart (HP:0011723)2.06368935
91Abnormal hair whorl (HP:0010721)2.05075050
92Abnormality of the lower motor neuron (HP:0002366)2.03975768
93Iris hypopigmentation (HP:0007730)2.03363491
94Choroideremia (HP:0001139)2.03065021
95Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.02816552
96Absent septum pellucidum (HP:0001331)2.00667694
97Poor eye contact (HP:0000817)2.00594201
98Pendular nystagmus (HP:0012043)2.00468173
99Type II lissencephaly (HP:0007260)2.00300532
100Congenital stationary night blindness (HP:0007642)10.9691879
101Attenuation of retinal blood vessels (HP:0007843)1.99725566
102Torticollis (HP:0000473)1.97509313
103Pigmentary retinal degeneration (HP:0001146)1.97027801
104Fetal akinesia sequence (HP:0001989)1.96425979
105Photophobia (HP:0000613)1.95758335
106Submucous cleft hard palate (HP:0000176)1.94948722
107Status epilepticus (HP:0002133)1.94449064
108Bowel incontinence (HP:0002607)1.93896314
109Polyphagia (HP:0002591)1.91759786
110Intellectual disability, severe (HP:0010864)1.91446485
111Abnormality of the fovea (HP:0000493)1.91284213
112Ulnar bowing (HP:0003031)1.90709808
113Gait imbalance (HP:0002141)1.90480222
114Severe Myopia (HP:0011003)1.88998132
115Visual hallucinations (HP:0002367)1.88969661
116Abolished electroretinogram (ERG) (HP:0000550)1.88745665
117Palpitations (HP:0001962)1.88594930
118Distal sensory impairment (HP:0002936)1.87047183
119Abnormal eating behavior (HP:0100738)1.85839997
120Muscle fiber atrophy (HP:0100295)1.85199271
121Distal upper limb amyotrophy (HP:0007149)1.84779117
122Upper limb amyotrophy (HP:0009129)1.84779117
123Abnormality of the vocal cords (HP:0008777)1.83087726
124Type II diabetes mellitus (HP:0005978)1.82878595
125Partial agenesis of the corpus callosum (HP:0001338)1.82238490
126Scanning speech (HP:0002168)1.81814771
127Easy fatigability (HP:0003388)1.81418458
128Testicular atrophy (HP:0000029)1.81113766
129Joint stiffness (HP:0001387)1.81097028
130Truncal ataxia (HP:0002078)1.81001514
131Aplasia/Hypoplasia affecting the retina (HP:0008061)1.80746528
132Hypercortisolism (HP:0001578)1.80438494
133Abnormal large intestine physiology (HP:0012700)1.79047623
134Arthropathy (HP:0003040)1.78647032
135Ocular albinism (HP:0001107)1.78420605
136Hyperacusis (HP:0010780)1.78014626
137Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76714688
138Narrow nasal bridge (HP:0000446)1.76654143
139Urinary urgency (HP:0000012)1.76643615
140Myotonia (HP:0002486)1.76304815
141Upper limb muscle weakness (HP:0003484)1.74772773
142Nuclear cataract (HP:0100018)1.74585425
143Abnormal social behavior (HP:0012433)1.74575193
144Impaired social interactions (HP:0000735)1.74575193
145Genetic anticipation (HP:0003743)1.74278864
146Dysdiadochokinesis (HP:0002075)1.73208155
147Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.72793878
148Atelectasis (HP:0100750)1.72568531
149Urinary bladder sphincter dysfunction (HP:0002839)1.72319257
150Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71401463
151Morphological abnormality of the pyramidal tract (HP:0002062)1.70590654
152Abnormality of dental color (HP:0011073)1.70225794
153Myopathic facies (HP:0002058)1.69772682
154Postural instability (HP:0002172)1.69706672
155Shawl scrotum (HP:0000049)1.69464022
156Hypsarrhythmia (HP:0002521)1.68817682
157Aplasia/Hypoplasia of the macula (HP:0008059)1.68810445
158Abnormal EKG (HP:0003115)1.68477312
159Failure to thrive in infancy (HP:0001531)1.68233968
160Thin ribs (HP:0000883)1.68080737
161Neoplasm of the heart (HP:0100544)1.67766858
162Autism (HP:0000717)1.66373269
163Dysmetria (HP:0001310)1.66037909
164Hypoplasia of the corpus callosum (HP:0002079)1.65719407
165Type 2 muscle fiber atrophy (HP:0003554)1.64303195
166Abnormality of reticulocytes (HP:0004312)1.63151583
167Abnormality of the aortic arch (HP:0012303)1.62531196
168Mask-like facies (HP:0000298)1.59176340
169Insomnia (HP:0100785)1.58746218
170Poor suck (HP:0002033)1.58232502
171Long palpebral fissure (HP:0000637)1.56935993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK13.86241585
2MINK13.78169365
3LMTK23.75589505
4PHKG23.07703830
5PHKG13.07703830
6TRIB33.07619232
7NTRK33.03026239
8SIK22.95073184
9EPHA32.92163865
10NEK12.89462793
11PAK62.77624346
12MAPK152.52675992
13NTRK22.43782796
14SIK12.36255029
15RIPK12.33955387
16NME12.29350009
17STK38L2.28463935
18MATK2.17279188
19KSR22.17157063
20MAP3K92.08591165
21UHMK12.02779647
22CASK1.96989763
23STK381.94187795
24TYRO31.92759473
25PRPF4B1.92399797
26EPHA41.85386323
27PBK1.83079963
28WNK41.82766928
29PINK11.66474059
30MARK11.63536325
31EEF2K1.60639868
32PRKD21.60317000
33ICK1.55788536
34TNK21.52547573
35MAP3K41.45820529
36MAP3K131.45478370
37DAPK21.42900783
38WNK11.41732682
39DYRK1A1.41284386
40SGK2231.38060746
41SGK4941.38060746
42MAPKAPK31.36022961
43FER1.34542452
44LATS21.32905459
45RPS6KB21.31534756
46ARAF1.26722054
47PKN11.25413609
48CDK191.22975007
49STK111.12430630
50CAMK41.11785217
51CAMK1D1.11220696
52SCYL21.07125732
53MAP2K61.04698685
54PRKG21.04463579
55MAP3K61.04008446
56MAPK131.03860370
57SGK21.01665384
58PRKAA10.98966057
59MAP3K20.98614007
60PRKD30.97450012
61MAP3K70.96834754
62MAPK120.95956842
63CAMKK10.93919964
64NEK90.93116209
65CAMK1G0.92671987
66MAP2K70.92336603
67FES0.90849122
68MAP2K10.87995966
69CDK50.87127234
70PRKCG0.87019102
71TAOK20.86426075
72RPS6KA20.83438085
73SIK30.83325315
74RET0.83254009
75CDK140.83022778
76CAMK2D0.82048758
77MUSK0.80456924
78RPS6KL10.78226864
79RPS6KC10.78226864
80PDPK10.76867594
81GRK50.75001518
82MAP2K40.74865653
83SGK30.74255527
84CAMKK20.72293012
85ERBB20.70206717
86DYRK1B0.69446199
87ROCK20.68653948
88BRD40.67795381
89MAPK100.67360245
90RPS6KA60.65573380
91PAK30.65477116
92SGK10.65320996
93CLK10.64570775
94MTOR0.63864892
95FGFR20.63648921
96DDR20.61824744
97LIMK10.60410585
98PRKCE0.59690368
99DYRK20.59555071
100MAP3K110.56863498
101PDK10.56730285
102PRKD10.55064591
103MAPK110.53133053
104AKT30.53058635
105RIPK40.52898152
106ADRBK10.52809216
107PRKG10.50522653
108CAMK2A0.50397980
109CDK180.48565953
110BRAF0.48129742
111ROCK10.47773760
112PRKACB0.47182474
113INSRR0.45924732
114CDK150.45260581
115PRKCZ0.45177295
116CSNK1E0.44646052
117CDC42BPA0.44325700
118MARK20.44322835
119CAMK2B0.43767249
120GRK10.42624338
121CAMK2G0.42074411
122MAP3K10.41706117
123PRKCA0.41517664
124PRKACA0.41338107
125CAMK10.39310677
126IRAK20.39224541
127PRKCB0.39192143
128ERN10.39040847
129RPS6KA30.38335331
130BRSK10.36725426
131RPS6KA10.36617406
132PRKCH0.36323812
133PKN20.35476851
134MAP2K20.34791555
135MAPK80.34216494
136BMX0.33893082
137AKT20.33661155
138MAP3K140.33628795
139CDK11A0.33326666
140BMPR1B0.32538143
141CDK30.30664363
142GSK3B0.30148220
143PRKACG0.29887175

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.31948035
2Nicotine addiction_Homo sapiens_hsa050333.62617547
3GABAergic synapse_Homo sapiens_hsa047273.21748569
4Phototransduction_Homo sapiens_hsa047443.05014852
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.80069299
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65505511
7Morphine addiction_Homo sapiens_hsa050322.58751664
8Olfactory transduction_Homo sapiens_hsa047402.58081060
9Circadian entrainment_Homo sapiens_hsa047132.37245086
10Circadian rhythm_Homo sapiens_hsa047102.34550675
11Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.29167678
12Insulin secretion_Homo sapiens_hsa049112.23907967
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.06813240
14Cholinergic synapse_Homo sapiens_hsa047251.97718186
15Salivary secretion_Homo sapiens_hsa049701.85885280
16Renin secretion_Homo sapiens_hsa049241.85504110
17Collecting duct acid secretion_Homo sapiens_hsa049661.82862849
18Taste transduction_Homo sapiens_hsa047421.72459969
19Sulfur relay system_Homo sapiens_hsa041221.71679013
20Glutamatergic synapse_Homo sapiens_hsa047241.71402745
21Notch signaling pathway_Homo sapiens_hsa043301.70621547
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70386874
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.67015910
24Fructose and mannose metabolism_Homo sapiens_hsa000511.64109120
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55628961
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.54676663
27Dopaminergic synapse_Homo sapiens_hsa047281.48799737
28Oxytocin signaling pathway_Homo sapiens_hsa049211.46393542
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43521413
30Serotonergic synapse_Homo sapiens_hsa047261.42385182
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38262302
32Cardiac muscle contraction_Homo sapiens_hsa042601.33245333
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29896938
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26629605
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24251028
36Dilated cardiomyopathy_Homo sapiens_hsa054141.16043411
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13855421
38Gap junction_Homo sapiens_hsa045401.13394406
39Calcium signaling pathway_Homo sapiens_hsa040201.13088806
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.11658243
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.07645990
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07225087
43* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04107042
44Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03492362
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01381089
46Hedgehog signaling pathway_Homo sapiens_hsa043401.01055643
47Vibrio cholerae infection_Homo sapiens_hsa051100.99191328
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98952862
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95423017
50Vitamin B6 metabolism_Homo sapiens_hsa007500.91283859
51GnRH signaling pathway_Homo sapiens_hsa049120.91085916
52Biosynthesis of amino acids_Homo sapiens_hsa012300.88221805
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87629870
54Lysine degradation_Homo sapiens_hsa003100.86821946
55Type II diabetes mellitus_Homo sapiens_hsa049300.84158687
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82603292
57Prion diseases_Homo sapiens_hsa050200.82265557
58Gastric acid secretion_Homo sapiens_hsa049710.82250542
59Choline metabolism in cancer_Homo sapiens_hsa052310.80033238
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79979374
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.78283603
62Melanoma_Homo sapiens_hsa052180.75934117
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75289813
64mTOR signaling pathway_Homo sapiens_hsa041500.75237510
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73770301
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73719327
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71384567
68Long-term potentiation_Homo sapiens_hsa047200.69387446
69Galactose metabolism_Homo sapiens_hsa000520.68686783
70cAMP signaling pathway_Homo sapiens_hsa040240.68661349
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67743751
72Pentose phosphate pathway_Homo sapiens_hsa000300.66923543
73Arginine and proline metabolism_Homo sapiens_hsa003300.66666098
74Long-term depression_Homo sapiens_hsa047300.65638605
75Rap1 signaling pathway_Homo sapiens_hsa040150.65500578
76Inositol phosphate metabolism_Homo sapiens_hsa005620.65112837
77MAPK signaling pathway_Homo sapiens_hsa040100.64577799
78Glucagon signaling pathway_Homo sapiens_hsa049220.61554090
79Bile secretion_Homo sapiens_hsa049760.60070061
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59040574
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.58900059
82Mineral absorption_Homo sapiens_hsa049780.58242798
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58170058
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56666114
85Endocytosis_Homo sapiens_hsa041440.56529443
86Dorso-ventral axis formation_Homo sapiens_hsa043200.56287646
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54913769
88Pyruvate metabolism_Homo sapiens_hsa006200.54124154
89Ovarian steroidogenesis_Homo sapiens_hsa049130.54023861
90Pancreatic secretion_Homo sapiens_hsa049720.53874882
91Insulin signaling pathway_Homo sapiens_hsa049100.52342550
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.51827138
93ErbB signaling pathway_Homo sapiens_hsa040120.51160264
94Arginine biosynthesis_Homo sapiens_hsa002200.50308612
95Axon guidance_Homo sapiens_hsa043600.49770993
96Glioma_Homo sapiens_hsa052140.49557692
97Renal cell carcinoma_Homo sapiens_hsa052110.49420790
98Estrogen signaling pathway_Homo sapiens_hsa049150.48110788
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47855986
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47470442
101Chronic myeloid leukemia_Homo sapiens_hsa052200.46149534
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44514066
103Hippo signaling pathway_Homo sapiens_hsa043900.44191734
104Prolactin signaling pathway_Homo sapiens_hsa049170.43593741
105Ras signaling pathway_Homo sapiens_hsa040140.43272939
106Regulation of autophagy_Homo sapiens_hsa041400.43031938
107Melanogenesis_Homo sapiens_hsa049160.42995294
108Phagosome_Homo sapiens_hsa041450.42831698
109Carbon metabolism_Homo sapiens_hsa012000.42455196
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.41414996
111Endometrial cancer_Homo sapiens_hsa052130.40403666
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38965804
113Amphetamine addiction_Homo sapiens_hsa050310.38946796
114Thyroid hormone synthesis_Homo sapiens_hsa049180.37796619
115Salmonella infection_Homo sapiens_hsa051320.37752364
116Alcoholism_Homo sapiens_hsa050340.35003273
117Thyroid cancer_Homo sapiens_hsa052160.34442215
118Oocyte meiosis_Homo sapiens_hsa041140.34244953
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33421999
120Rheumatoid arthritis_Homo sapiens_hsa053230.32672562
121HIF-1 signaling pathway_Homo sapiens_hsa040660.32669164
122VEGF signaling pathway_Homo sapiens_hsa043700.31513181
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30554760
124AMPK signaling pathway_Homo sapiens_hsa041520.29772377
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28693581
126Cocaine addiction_Homo sapiens_hsa050300.26970425
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25560989

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