ASIC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1homocysteine metabolic process (GO:0050667)7.81420320
2postsynaptic membrane organization (GO:0001941)6.76004906
3microtubule nucleation (GO:0007020)6.12319079
4regulation of plasminogen activation (GO:0010755)6.06824489
5regulation of synapse structural plasticity (GO:0051823)5.85832974
6folic acid-containing compound biosynthetic process (GO:0009396)5.73172207
7cysteine metabolic process (GO:0006534)5.72365553
8sulfur amino acid catabolic process (GO:0000098)5.70237078
9epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.57857851
10tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.54439961
11RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.54439961
12synaptic vesicle maturation (GO:0016188)5.54180456
13regulation of short-term neuronal synaptic plasticity (GO:0048172)5.47244422
14positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.41915343
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.40154923
16response to pheromone (GO:0019236)5.27096967
17prepulse inhibition (GO:0060134)5.23786021
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.18980979
19auditory behavior (GO:0031223)5.11632509
20vocalization behavior (GO:0071625)5.00801102
21locomotory exploration behavior (GO:0035641)4.99265096
22adenosine metabolic process (GO:0046085)4.98390603
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.85899954
24adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.78322469
25striatum development (GO:0021756)4.73022911
26synaptic transmission, dopaminergic (GO:0001963)4.72498455
27white fat cell differentiation (GO:0050872)4.66508802
28negative regulation of cytosolic calcium ion concentration (GO:0051481)4.66098329
29protein localization to synapse (GO:0035418)4.65104619
30synaptic vesicle exocytosis (GO:0016079)4.64842890
31response to auditory stimulus (GO:0010996)4.58394599
32cochlea development (GO:0090102)4.55309810
33negative regulation of DNA biosynthetic process (GO:2000279)4.55009677
34regulation of glutamate receptor signaling pathway (GO:1900449)4.53811280
35dendritic spine morphogenesis (GO:0060997)4.50301582
36layer formation in cerebral cortex (GO:0021819)4.48869062
37positive regulation of endothelial cell differentiation (GO:0045603)4.47856245
38eye photoreceptor cell differentiation (GO:0001754)4.46752331
39photoreceptor cell differentiation (GO:0046530)4.46752331
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.43711627
41regulation of long-term neuronal synaptic plasticity (GO:0048169)4.40320903
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.37903897
43negative regulation of catenin import into nucleus (GO:0035414)4.36836890
44primary amino compound metabolic process (GO:1901160)4.36208711
45regulation of neuronal synaptic plasticity (GO:0048168)4.36015741
46neurotransmitter-gated ion channel clustering (GO:0072578)4.33976124
47innervation (GO:0060384)4.33453965
48dopamine receptor signaling pathway (GO:0007212)4.31440493
49regulation of synaptic vesicle exocytosis (GO:2000300)4.30594138
50purine nucleotide salvage (GO:0032261)4.27784315
51presynaptic membrane assembly (GO:0097105)4.21073882
52positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.19822756
53positive regulation of synaptic transmission, GABAergic (GO:0032230)4.18527567
54behavioral response to nicotine (GO:0035095)4.05187849
55synaptic vesicle docking involved in exocytosis (GO:0016081)4.00596447
56neurotransmitter secretion (GO:0007269)3.96358983
57protein-chromophore linkage (GO:0018298)3.96111324
58inner ear receptor cell development (GO:0060119)3.92889711
59ionotropic glutamate receptor signaling pathway (GO:0035235)3.91242106
60neuron cell-cell adhesion (GO:0007158)3.88822368
61positive regulation of oligodendrocyte differentiation (GO:0048714)3.88700409
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.86207993
63histone H4-K12 acetylation (GO:0043983)3.85809043
64presynaptic membrane organization (GO:0097090)3.83657875
65alternative mRNA splicing, via spliceosome (GO:0000380)3.82733351
66negative regulation of Ras GTPase activity (GO:0034261)3.82522670
67exploration behavior (GO:0035640)3.81758816
68regulation of synaptic vesicle transport (GO:1902803)3.81352360
69regulation of dendritic spine morphogenesis (GO:0061001)3.78196537
70protein-cofactor linkage (GO:0018065)3.77367330
71L-serine metabolic process (GO:0006563)3.77075612
72neuron-neuron synaptic transmission (GO:0007270)3.75827832
73substrate-independent telencephalic tangential migration (GO:0021826)3.68427735
74substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.68427735
75pteridine-containing compound biosynthetic process (GO:0042559)3.68141484
76regulation of synaptic transmission, glutamatergic (GO:0051966)3.67994409
77glutamate secretion (GO:0014047)3.66561067
78response to amphetamine (GO:0001975)3.63815034
79regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.62017451
80regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.62017451
81neuromuscular process controlling balance (GO:0050885)3.61626053
82synaptic transmission, glutamatergic (GO:0035249)3.61533002
83mechanosensory behavior (GO:0007638)3.60819193
84membrane hyperpolarization (GO:0060081)3.60020482
85behavioral response to cocaine (GO:0048148)3.59358224
86long-term memory (GO:0007616)3.59135861
87positive regulation of neurotransmitter transport (GO:0051590)3.58117148
88visual learning (GO:0008542)3.55565673
89phosphatidylglycerol biosynthetic process (GO:0006655)3.55420882
90glutamate receptor signaling pathway (GO:0007215)3.53187883
91positive regulation of membrane potential (GO:0045838)3.52573770
92mitochondrial RNA metabolic process (GO:0000959)3.52522944
93positive regulation of synapse maturation (GO:0090129)3.52456214
94mating behavior (GO:0007617)3.51091107
95axon ensheathment in central nervous system (GO:0032291)3.48280679
96central nervous system myelination (GO:0022010)3.48280679
97behavioral defense response (GO:0002209)3.45826235
98behavioral fear response (GO:0001662)3.45826235
99neuronal ion channel clustering (GO:0045161)3.45440870
100transmission of nerve impulse (GO:0019226)3.45345467
101gamma-aminobutyric acid signaling pathway (GO:0007214)3.45305905
102cellular potassium ion homeostasis (GO:0030007)3.45052325
103regulation of excitatory postsynaptic membrane potential (GO:0060079)3.44775812
104neuron recognition (GO:0008038)3.42251500
105establishment of mitochondrion localization (GO:0051654)3.41607901
106regulation of postsynaptic membrane potential (GO:0060078)3.40381163
107desmosome organization (GO:0002934)3.40304870
108sodium ion export (GO:0071436)3.40108073
109negative regulation of keratinocyte proliferation (GO:0010839)3.39457108
110regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.39390421
111regulation of synaptic transmission, dopaminergic (GO:0032225)3.38797085
112cerebellar Purkinje cell differentiation (GO:0021702)3.37976811
113axonal fasciculation (GO:0007413)3.37904866
114regulation of female receptivity (GO:0045924)3.36434897
115cell migration involved in heart development (GO:0060973)3.33857322
116visual behavior (GO:0007632)3.31819973
117adenosine receptor signaling pathway (GO:0001973)3.31038880
118rRNA methylation (GO:0031167)3.30494324
119learning (GO:0007612)3.27483073
120dermatan sulfate biosynthetic process (GO:0030208)3.27383288
121regulation of gonadotropin secretion (GO:0032276)3.27005536
122positive regulation of dendritic spine development (GO:0060999)3.26850188
123pyrimidine nucleobase catabolic process (GO:0006208)3.26254967
124acrosome assembly (GO:0001675)3.26217366
125dendrite morphogenesis (GO:0048813)3.25670577
126regulation of synaptic plasticity (GO:0048167)3.25249535
127regulation of endothelial cell differentiation (GO:0045601)3.23045083
128regulation of sequestering of triglyceride (GO:0010889)3.22685584
129cartilage morphogenesis (GO:0060536)3.22219429
130cell migration in hindbrain (GO:0021535)3.17955483
131G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.17021623
132gamma-aminobutyric acid transport (GO:0015812)3.14604488
133regulation of neurotransmitter uptake (GO:0051580)3.14267096
134synaptic vesicle endocytosis (GO:0048488)3.13183369
135serine family amino acid biosynthetic process (GO:0009070)3.11252809
136neuronal action potential propagation (GO:0019227)3.10576015
137regulation of catecholamine metabolic process (GO:0042069)3.09716839
138regulation of dopamine metabolic process (GO:0042053)3.09716839
139positive regulation of neurotransmitter secretion (GO:0001956)3.09421010
140G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.08416824
141activation of protein kinase A activity (GO:0034199)3.07219337
142neurotransmitter transport (GO:0006836)3.07170361
143positive regulation of dendritic spine morphogenesis (GO:0061003)3.05937493
144sulfur amino acid biosynthetic process (GO:0000097)3.05739790
145membrane depolarization during action potential (GO:0086010)3.04040751
146membrane depolarization (GO:0051899)3.03445541
147regulation of dendritic spine development (GO:0060998)3.03373154
148regulation of glutamate secretion (GO:0014048)3.03032227
149fear response (GO:0042596)3.02134836
150regulation of neurotransmitter transport (GO:0051588)3.01935585
151cell communication by electrical coupling (GO:0010644)3.01351017
152cAMP catabolic process (GO:0006198)3.00946770
153negative regulation of telomerase activity (GO:0051974)2.99142648
154organic cation transport (GO:0015695)2.98116669
155response to lipoprotein particle (GO:0055094)2.93016715
156tetrahydrofolate metabolic process (GO:0046653)2.90913779
157dermatan sulfate metabolic process (GO:0030205)2.89272503
158adult feeding behavior (GO:0008343)2.86736762
159galactose catabolic process (GO:0019388)2.85328713
160galactose metabolic process (GO:0006012)2.82434851
161G-protein coupled receptor internalization (GO:0002031)2.82164400
162serine family amino acid catabolic process (GO:0009071)2.81971385
163folic acid-containing compound metabolic process (GO:0006760)2.75059814
164negative regulation of blood vessel endothelial cell migration (GO:0043537)2.71664439
165tRNA modification (GO:0006400)2.69810744
166nucleobase catabolic process (GO:0046113)2.67853662
167regulation of vitamin D biosynthetic process (GO:0060556)2.67221173
168rRNA modification (GO:0000154)2.66966643
169nucleoside transmembrane transport (GO:1901642)2.66410729
170growth hormone secretion (GO:0030252)2.66410024
171platelet dense granule organization (GO:0060155)2.65872182
172regulation of oligodendrocyte differentiation (GO:0048713)2.61700334
173adaptation of signaling pathway (GO:0023058)2.59665215
174negative regulation of astrocyte differentiation (GO:0048712)2.57775039
175regulation of neuron projection regeneration (GO:0070570)2.51670596
176regulation of axon regeneration (GO:0048679)2.51670596
177neural crest cell development (GO:0014032)2.48589078

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.84076490
2EZH2_22144423_ChIP-Seq_EOC_Human5.83635397
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.34167766
4GBX2_23144817_ChIP-Seq_PC3_Human3.14403483
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11922863
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09620713
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01706669
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.95492786
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.86253077
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83580071
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83580071
12REST_21632747_ChIP-Seq_MESCs_Mouse2.83399642
13VDR_22108803_ChIP-Seq_LS180_Human2.72166982
14SUZ12_27294783_Chip-Seq_ESCs_Mouse2.65907448
15DROSHA_22980978_ChIP-Seq_HELA_Human2.65808955
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.64939091
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.62043706
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.59101499
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.55339086
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55307864
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50127717
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46521565
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.46482724
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44590652
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.41702135
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.38638573
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.35430141
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.26634831
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.17558744
30AR_21572438_ChIP-Seq_LNCaP_Human1.99658178
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.96587903
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94362343
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88487681
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.74957717
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65307636
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.61622523
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61133818
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.58952890
39KDM2B_26808549_Chip-Seq_K562_Human1.53123439
40P53_22127205_ChIP-Seq_FIBROBLAST_Human1.47943058
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46656238
42TAF15_26573619_Chip-Seq_HEK293_Human1.45170745
43RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43417608
44RING1B_27294783_Chip-Seq_NPCs_Mouse1.41620777
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41383330
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.40094373
47FUS_26573619_Chip-Seq_HEK293_Human1.39078736
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36367988
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34797801
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34310251
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33051830
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29611403
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25372965
54SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.25272821
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24698091
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23210816
57IGF1R_20145208_ChIP-Seq_DFB_Human1.23136849
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21683306
59TP53_22573176_ChIP-Seq_HFKS_Human1.21551245
60OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.21285846
61* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21122603
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21094495
63RNF2_27304074_Chip-Seq_NSC_Mouse1.20621070
64CTCF_27219007_Chip-Seq_Bcells_Human1.19906899
65AR_19668381_ChIP-Seq_PC3_Human1.19826774
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.19272761
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18561939
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17512847
69RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16896109
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16491010
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16139134
72SMAD4_21799915_ChIP-Seq_A2780_Human1.15099217
73ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14935901
74ZNF274_21170338_ChIP-Seq_K562_Hela1.14741834
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12429115
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10119634
77NCOR_22424771_ChIP-Seq_293T_Human1.10052995
78OCT1_27270436_Chip-Seq_PROSTATE_Human1.09243975
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09165813
80BCAT_22108803_ChIP-Seq_LS180_Human1.08015829
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07327738
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06917096
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05863212
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05025415
85CDX2_22108803_ChIP-Seq_LS180_Human1.03886193
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03090566
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02680624
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.02281539
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01932241
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01695133
91GATA1_26923725_Chip-Seq_HPCs_Mouse1.01326926
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00430931
93CBP_20019798_ChIP-Seq_JUKART_Human1.00430931
94KDM2B_26808549_Chip-Seq_REH_Human0.99708133
95TET1_21490601_ChIP-Seq_MESCs_Mouse0.98955715
96ER_23166858_ChIP-Seq_MCF-7_Human0.98674110
97SMAD4_21741376_ChIP-Seq_HESCs_Human0.98474332
98ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97940861
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97601452
100CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97452373
101SMAD4_21741376_ChIP-Seq_EPCs_Human0.97053492
102TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96698340
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96312155
104TP53_20018659_ChIP-ChIP_R1E_Mouse0.95157753
105AHR_22903824_ChIP-Seq_MCF-7_Human0.93911691
106SMAD3_21741376_ChIP-Seq_HESCs_Human0.93540224
107YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93472743
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92703112
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91554145
110STAT3_23295773_ChIP-Seq_U87_Human0.91106508
111JUN_21703547_ChIP-Seq_K562_Human0.91071073
112EWS_26573619_Chip-Seq_HEK293_Human0.90930376
113ARNT_22903824_ChIP-Seq_MCF-7_Human0.90738600
114TCF4_22108803_ChIP-Seq_LS180_Human0.90396684
115AR_25329375_ChIP-Seq_VCAP_Human0.90195589
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.89711143
117FLI1_21867929_ChIP-Seq_TH2_Mouse0.89562544
118KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89512692
119P300_19829295_ChIP-Seq_ESCs_Human0.88842043
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87794568
121TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87732528
122SMAD3_21741376_ChIP-Seq_ESCs_Human0.87540130
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87227313
124ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86697177
125TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86373500
126KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85483150
127ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83066106
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82424222
129RUNX2_22187159_ChIP-Seq_PCA_Human0.81185153
130KLF4_19829295_ChIP-Seq_ESCs_Human0.80921737
131EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.80855447
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.79876273
133TCF4_23295773_ChIP-Seq_U87_Human0.79390249
134LXR_22292898_ChIP-Seq_THP-1_Human0.79077991
135TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.78135238
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.76367714
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75787349
138ZNF217_24962896_ChIP-Seq_MCF-7_Human0.75786316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy6.07774829
2MP0004859_abnormal_synaptic_plasticity5.99341401
3MP0003880_abnormal_central_pattern3.90419928
4MP0003635_abnormal_synaptic_transmissio3.89841369
5MP0002063_abnormal_learning/memory/cond3.45203513
6MP0005670_abnormal_white_adipose3.29438561
7MP0009745_abnormal_behavioral_response3.16862931
8MP0004270_analgesia3.07019622
9MP0003183_abnormal_peptide_metabolism3.06228036
10MP0004147_increased_porphyrin_level3.00437275
11MP0005423_abnormal_somatic_nervous2.94896776
12MP0001529_abnormal_vocalization2.87905247
13MP0002064_seizures2.75804075
14MP0002572_abnormal_emotion/affect_behav2.62317794
15MP0001486_abnormal_startle_reflex2.60847918
16MP0009046_muscle_twitch2.44055795
17MP0001984_abnormal_olfaction2.35408541
18MP0002272_abnormal_nervous_system2.21342943
19MP0006276_abnormal_autonomic_nervous2.21114141
20MP0002909_abnormal_adrenal_gland2.20654514
21MP0001968_abnormal_touch/_nociception2.20430300
22MP0005360_urolithiasis2.16445654
23MP0005646_abnormal_pituitary_gland2.12745766
24MP0002734_abnormal_mechanical_nocicepti2.10411167
25MP0000778_abnormal_nervous_system2.04746716
26MP0002938_white_spotting1.96377616
27MP0003122_maternal_imprinting1.93556518
28MP0002557_abnormal_social/conspecific_i1.90575660
29MP0004811_abnormal_neuron_physiology1.87151862
30MP0002733_abnormal_thermal_nociception1.83406529
31MP0001970_abnormal_pain_threshold1.81262700
32MP0002184_abnormal_innervation1.80140363
33MP0004924_abnormal_behavior1.79171291
34MP0005386_behavior/neurological_phenoty1.79171291
35MP0003705_abnormal_hypodermis_morpholog1.78454523
36MP0000569_abnormal_digit_pigmentation1.77675271
37MP0005551_abnormal_eye_electrophysiolog1.75305107
38MP0001440_abnormal_grooming_behavior1.73741099
39MP0003136_yellow_coat_color1.72652718
40MP0005171_absent_coat_pigmentation1.69552482
41MP0005645_abnormal_hypothalamus_physiol1.63587189
42MP0008569_lethality_at_weaning1.63355579
43MP0008961_abnormal_basal_metabolism1.62511288
44MP0001501_abnormal_sleep_pattern1.56681740
45MP0004043_abnormal_pH_regulation1.53828900
46MP0002095_abnormal_skin_pigmentation1.53262565
47MP0001502_abnormal_circadian_rhythm1.52642406
48MP0002067_abnormal_sensory_capabilities1.51968987
49MP0000955_abnormal_spinal_cord1.49588996
50MP0002638_abnormal_pupillary_reflex1.47903327
51MP0004133_heterotaxia1.47505507
52MP0002882_abnormal_neuron_morphology1.46875067
53MP0010386_abnormal_urinary_bladder1.37405774
54MP0005367_renal/urinary_system_phenotyp1.37162188
55MP0000516_abnormal_urinary_system1.37162188
56MP0004885_abnormal_endolymph1.36614392
57MP0001986_abnormal_taste_sensitivity1.34596191
58MP0002090_abnormal_vision1.33264288
59MP0003879_abnormal_hair_cell1.31499854
60MP0002066_abnormal_motor_capabilities/c1.29604437
61MP0002736_abnormal_nociception_after1.27184669
62MP0000631_abnormal_neuroendocrine_gland1.25893481
63MP0002735_abnormal_chemical_nociception1.25699510
64MP0001188_hyperpigmentation1.24271226
65MP0003329_amyloid_beta_deposits1.23579296
66MP0000026_abnormal_inner_ear1.23503228
67MP0004130_abnormal_muscle_cell1.16961232
68MP0004858_abnormal_nervous_system1.16772247
69MP0002152_abnormal_brain_morphology1.14842495
70MP0005394_taste/olfaction_phenotype1.13091089
71MP0005499_abnormal_olfactory_system1.13091089
72MP0010030_abnormal_orbit_morphology1.12470957
73MP0005409_darkened_coat_color1.12028274
74MP0002653_abnormal_ependyma_morphology1.11565115
75MP0001905_abnormal_dopamine_level1.09743472
76MP0003137_abnormal_impulse_conducting1.08279352
77MP0006072_abnormal_retinal_apoptosis1.07166287
78MP0002069_abnormal_eating/drinking_beha1.02693604
79MP0005253_abnormal_eye_physiology1.02040471
80MP0009780_abnormal_chondrocyte_physiolo1.01886767
81MP0001485_abnormal_pinna_reflex1.01739645
82MP0000647_abnormal_sebaceous_gland1.00868051
83MP0001177_atelectasis1.00332807
84MP0004142_abnormal_muscle_tone0.98809162
85MP0003633_abnormal_nervous_system0.98113114
86MP0004085_abnormal_heartbeat0.97386403
87MP0000751_myopathy0.96455921
88MP0005332_abnormal_amino_acid0.93938174
89MP0002752_abnormal_somatic_nervous0.93176936
90MP0002229_neurodegeneration0.92913210
91MP0006292_abnormal_olfactory_placode0.87325284
92MP0000013_abnormal_adipose_tissue0.87271023
93MP0008872_abnormal_physiological_respon0.85727021
94MP0003787_abnormal_imprinting0.84601890
95MP0003890_abnormal_embryonic-extraembry0.83803053
96MP0003631_nervous_system_phenotype0.83079392
97MP0001764_abnormal_homeostasis0.82651369
98MP0003075_altered_response_to0.82001677
99MP0002876_abnormal_thyroid_physiology0.79306803
100MP0003698_abnormal_male_reproductive0.79251417
101MP0008995_early_reproductive_senescence0.78934467
102MP0003121_genomic_imprinting0.78450303
103MP0003283_abnormal_digestive_organ0.77442057
104MP0003634_abnormal_glial_cell0.77352804
105MP0004742_abnormal_vestibular_system0.76402580
106MP0001944_abnormal_pancreas_morphology0.75964595
107MP0000534_abnormal_ureter_morphology0.75667577
108MP0003942_abnormal_urinary_system0.75637561
109MP0008874_decreased_physiological_sensi0.75566882
110MP0004233_abnormal_muscle_weight0.75109993
111MP0000920_abnormal_myelination0.74997913
112MP0002837_dystrophic_cardiac_calcinosis0.73516215
113MP0003861_abnormal_nervous_system0.71503833
114MP0001270_distended_abdomen0.68535230
115MP0002396_abnormal_hematopoietic_system0.67498309
116MP0005248_abnormal_Harderian_gland0.67352673
117MP0008775_abnormal_heart_ventricle0.67158690
118MP0001756_abnormal_urination0.65641574
119MP0005535_abnormal_body_temperature0.65502285
120MP0004145_abnormal_muscle_electrophysio0.64838206
121MP0002210_abnormal_sex_determination0.64776475
122MP0001664_abnormal_digestion0.63540130
123MP0003690_abnormal_glial_cell0.60499257
124MP0005167_abnormal_blood-brain_barrier0.59886654
125MP0005195_abnormal_posterior_eye0.59724576
126MP0001661_extended_life_span0.58985090
127MP0005410_abnormal_fertilization0.57296624
128MP0002234_abnormal_pharynx_morphology0.56893410
129MP0003632_abnormal_nervous_system0.56201557
130MP0001963_abnormal_hearing_physiology0.55914102
131MP0001943_abnormal_respiration0.55740864
132MP0002089_abnormal_postnatal_growth/wei0.55323299
133MP0002102_abnormal_ear_morphology0.54038355
134MP0002751_abnormal_autonomic_nervous0.53552951

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)7.57083143
2Abnormality of alanine metabolism (HP:0010916)7.57083143
3Hyperalaninemia (HP:0003348)7.57083143
4Myokymia (HP:0002411)7.27693047
5Focal motor seizures (HP:0011153)6.02460985
6Congenital sensorineural hearing impairment (HP:0008527)5.97049198
7Constricted visual fields (HP:0001133)5.55462493
8Focal seizures (HP:0007359)5.02115417
9White forelock (HP:0002211)4.86822138
10Patchy hypopigmentation of hair (HP:0011365)4.32522066
11Birth length less than 3rd percentile (HP:0003561)4.29935911
12Homocystinuria (HP:0002156)4.28627283
13Abnormality of homocysteine metabolism (HP:0010919)4.28627283
14Esophageal varix (HP:0002040)4.27306830
15Ankle clonus (HP:0011448)4.21652796
16Decreased electroretinogram (ERG) amplitude (HP:0000654)4.17472310
17Epileptic encephalopathy (HP:0200134)4.04017946
18Poor eye contact (HP:0000817)3.82964683
19Spontaneous hematomas (HP:0007420)3.80051843
20Visual hallucinations (HP:0002367)3.62624597
21Torticollis (HP:0000473)3.60421958
22Polyphagia (HP:0002591)3.59850978
23Congenital stationary night blindness (HP:0007642)3.58406826
24Attenuation of retinal blood vessels (HP:0007843)3.52876898
25Abnormal eating behavior (HP:0100738)3.52680842
26Failure to thrive in infancy (HP:0001531)3.49680862
27Abnormal social behavior (HP:0012433)3.39986620
28Impaired social interactions (HP:0000735)3.39986620
29Febrile seizures (HP:0002373)3.38428008
30Broad-based gait (HP:0002136)3.36984301
31Impaired vibration sensation in the lower limbs (HP:0002166)3.34781269
32Depression (HP:0000716)3.32051242
33Absence seizures (HP:0002121)3.18294377
34Focal dystonia (HP:0004373)3.05125090
35Supranuclear gaze palsy (HP:0000605)3.04758792
36Generalized tonic-clonic seizures (HP:0002069)3.04752028
37Heterochromia iridis (HP:0001100)3.04294755
38Anxiety (HP:0000739)3.04282663
39Agitation (HP:0000713)3.03511814
40Craniofacial dystonia (HP:0012179)3.03304161
41Urinary urgency (HP:0000012)3.01132686
42Action tremor (HP:0002345)2.97123538
43Central scotoma (HP:0000603)2.96366537
44Chronic hepatic failure (HP:0100626)2.95837258
45Abnormal umbilical cord blood vessels (HP:0011403)2.95743878
46Single umbilical artery (HP:0001195)2.95743878
47Abnormality of the fetal cardiovascular system (HP:0010948)2.95743878
48Papilledema (HP:0001085)2.93195190
49Annular pancreas (HP:0001734)2.92046229
50Pointed chin (HP:0000307)2.91782129
51Progressive cerebellar ataxia (HP:0002073)2.90853382
52Abnormality of serum amino acid levels (HP:0003112)2.89741961
53Abnormality of the lower motor neuron (HP:0002366)2.89228429
54Dialeptic seizures (HP:0011146)2.88861678
55Spastic gait (HP:0002064)2.86290402
56Hemiparesis (HP:0001269)2.85159115
57Dysdiadochokinesis (HP:0002075)2.83546731
58Truncal ataxia (HP:0002078)2.83052606
59Ankyloglossia (HP:0010296)2.81866918
60Urinary bladder sphincter dysfunction (HP:0002839)2.79437295
61Mutism (HP:0002300)2.79077022
62Abnormality of sulfur amino acid metabolism (HP:0004339)2.77933854
63Abnormal EKG (HP:0003115)2.75252208
64Abnormality of cochlea (HP:0000375)2.63477084
65Poor speech (HP:0002465)2.61645706
66Morphological abnormality of the inner ear (HP:0011390)2.60108240
67Excessive salivation (HP:0003781)2.59464805
68Drooling (HP:0002307)2.59464805
69Chorioretinal atrophy (HP:0000533)2.59031579
70Prolonged QT interval (HP:0001657)2.58810768
71Insomnia (HP:0100785)2.56792810
72Visceral angiomatosis (HP:0100761)2.55912728
73Pendular nystagmus (HP:0012043)2.54728735
74Stereotypic behavior (HP:0000733)2.53468585
75Clonus (HP:0002169)2.48253161
76Pigmentary retinal degeneration (HP:0001146)2.44246891
77Conjunctival telangiectasia (HP:0000524)2.43799836
78Obsessive-compulsive behavior (HP:0000722)2.43612839
79Lower limb muscle weakness (HP:0007340)2.42024702
80Conjugated hyperbilirubinemia (HP:0002908)2.41661730
81Sleep apnea (HP:0010535)2.40720729
82Neoplasm of the heart (HP:0100544)2.39435113
83Amblyopia (HP:0000646)2.39420107
84Gaze-evoked nystagmus (HP:0000640)2.39412347
85Tubulointerstitial nephritis (HP:0001970)2.38536005
86Dysmetria (HP:0001310)2.36878959
87Anorexia (HP:0002039)2.34879736
88Limb dystonia (HP:0002451)2.33501349
89Resting tremor (HP:0002322)2.32942504
90Atonic seizures (HP:0010819)2.27732821
91Maternal diabetes (HP:0009800)2.24556890
92EEG with generalized epileptiform discharges (HP:0011198)2.21868797
93Postural instability (HP:0002172)2.21714838
94Exotropia (HP:0000577)2.18526709
95Intention tremor (HP:0002080)2.17627876
96Epileptiform EEG discharges (HP:0011182)2.17071185
97Hemangiomatosis (HP:0007461)2.16903338
98Progressive inability to walk (HP:0002505)2.16300432
99Myocardial infarction (HP:0001658)2.16026837
100Hemiplegia (HP:0002301)2.15148762
101Impaired smooth pursuit (HP:0007772)2.11974702
102Abnormal respiratory epithelium morphology (HP:0012253)2.11443504
103Abnormal respiratory motile cilium morphology (HP:0005938)2.11443504
104Lower limb amyotrophy (HP:0007210)2.10670216
105Abnormality of macular pigmentation (HP:0008002)2.10420494
106Ileus (HP:0002595)2.10031328
107Scanning speech (HP:0002168)2.09562401
108Hypopigmentation of the fundus (HP:0007894)2.08834547
109Specific learning disability (HP:0001328)2.08617317
110Hyperventilation (HP:0002883)2.08594853
111Incomplete penetrance (HP:0003829)2.08042781
112Anencephaly (HP:0002323)2.07117796
113Esotropia (HP:0000565)2.06781840
114Hypsarrhythmia (HP:0002521)2.05012602
115Supernumerary spleens (HP:0009799)2.02686027
116Hypoventilation (HP:0002791)2.02626802
117Chronic otitis media (HP:0000389)2.02507329
118Truncus arteriosus (HP:0001660)2.02167356
119Abnormality of oral frenula (HP:0000190)2.02159103
120Type II diabetes mellitus (HP:0005978)2.01629205
121Oligomenorrhea (HP:0000876)2.00474431
122Elfin facies (HP:0004428)1.99985704
123Pulmonary embolism (HP:0002204)1.99631439
124Scotoma (HP:0000575)1.98656933
125Megalencephaly (HP:0001355)1.97877039
126Hyperacusis (HP:0010780)1.97798923
127Ventricular fibrillation (HP:0001663)1.97575191
128True hermaphroditism (HP:0010459)1.97294857
129Genetic anticipation (HP:0003743)1.95747613
130Hypoplastic left heart (HP:0004383)1.95412720
131Abnormality of the labia minora (HP:0012880)1.95209072
132Distal upper limb amyotrophy (HP:0007149)1.94693154
133Upper limb amyotrophy (HP:0009129)1.94693154
134Hypomagnesemia (HP:0002917)1.94126814
135Oligodactyly (hands) (HP:0001180)1.93920309
136Status epilepticus (HP:0002133)1.93276085
137Abnormality of ocular smooth pursuit (HP:0000617)1.92844088
138Impaired vibratory sensation (HP:0002495)1.92079010
139Bradykinesia (HP:0002067)1.92012293
140Pancreatic fibrosis (HP:0100732)1.91971613
141Abolished electroretinogram (ERG) (HP:0000550)1.91404108
142Bony spicule pigmentary retinopathy (HP:0007737)1.90668504
143Absent speech (HP:0001344)1.90626258
144Polygenic inheritance (HP:0010982)1.88575992
145Hypoalphalipoproteinemia (HP:0003233)1.88399544
146Generalized hypotonia (HP:0001290)1.88061606
147Dysmetric saccades (HP:0000641)1.87943103
148Cortical visual impairment (HP:0100704)1.87410290
149Dyskinesia (HP:0100660)1.83444827
150Severe visual impairment (HP:0001141)1.82637774
151Postural tremor (HP:0002174)1.81059395
152Abnormality of the vasculature of the conjunctiva (HP:0008054)1.80477390
153Arteriovenous malformation (HP:0100026)1.80159183
154Hypoplasia of the brainstem (HP:0002365)1.79741136
155Aplasia/Hypoplasia of the brainstem (HP:0007362)1.79741136
156Bowel incontinence (HP:0002607)1.79535602
157Hyperglycinemia (HP:0002154)1.79502704
158Epidermoid cyst (HP:0200040)1.79233795
159Abnormal rod and cone electroretinograms (HP:0008323)1.77101836
160Complete atrioventricular canal defect (HP:0001674)1.76998167
161Keratoconus (HP:0000563)1.76699876
162Increased corneal curvature (HP:0100692)1.76699876
163Inability to walk (HP:0002540)1.76666923
164Insulin-resistant diabetes mellitus (HP:0000831)1.72311716
165Generalized aminoaciduria (HP:0002909)1.72083958
166Toxemia of pregnancy (HP:0100603)1.70827349
167Abnormality of the carotid arteries (HP:0005344)1.69766932
168Abnormality of the heme biosynthetic pathway (HP:0010472)1.68690007
169Aplasia/Hypoplasia of the tibia (HP:0005772)1.67955331
170Pancreatic cysts (HP:0001737)1.67209517
171Myopathic facies (HP:0002058)1.66105673
172Abnormality of midbrain morphology (HP:0002418)1.65907312
173Molar tooth sign on MRI (HP:0002419)1.65907312
174Portal hypertension (HP:0001409)1.65504779
175Cone-rod dystrophy (HP:0000548)1.59794504
176Hypoplastic heart (HP:0001961)1.59358286
177Abnormality of the renal collecting system (HP:0004742)1.58982419
178Cavernous hemangioma (HP:0001048)1.58361407
179Cutaneous finger syndactyly (HP:0010554)1.58316504

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.53123688
2MAP3K94.19476914
3NTRK33.54143478
4MARK13.23162711
5WNK33.20412533
6NTRK22.79787715
7MINK12.63053085
8KSR12.56377749
9SIK32.47970620
10MAP3K32.39997597
11MAP2K32.27648270
12PAK62.19087081
13ACVR1B2.10454007
14KSR22.06198830
15PRPF4B2.04486602
16DAPK22.02636339
17CDK92.01470407
18MAP3K42.01404507
19PRKD31.95800709
20FGR1.91210023
21SIK21.88051795
22TYRO31.86854831
23PKN11.73363571
24UHMK11.73131795
25CAMKK11.65615458
26CDK51.63953424
27JAK31.63834149
28CCNB11.55796355
29FRK1.53361960
30NEK61.52800722
31FES1.46628151
32MAP2K71.41169963
33NTRK11.38746576
34BCR1.27495491
35FGFR21.25343049
36TNIK1.24523566
37ADRBK11.18758788
38TAOK11.17803510
39CDK181.16563825
40MAP3K131.14775136
41DAPK11.13740314
42CDK191.12392505
43PNCK1.11080592
44EPHB21.09935831
45MAP2K41.09889479
46ARAF1.08384152
47MAPK131.08060783
48RIPK41.07669690
49ICK1.06125341
50CDK151.04307799
51STK381.03534633
52NEK11.03179459
53CDK141.00775951
54RPS6KB21.00345612
55SGK4940.98759506
56SGK2230.98759506
57CAMK2D0.97509136
58CSNK1A10.95624074
59CAMK2G0.93428527
60MAP3K120.92677528
61MARK20.92454975
62CDK11A0.91648185
63MAPKAPK50.90696710
64PHKG20.89601650
65PHKG10.89601650
66MAP4K20.89248309
67PRKCG0.82948734
68PRKCZ0.82051783
69PINK10.81502745
70ERBB20.81089380
71ADRBK20.79722705
72PDGFRA0.78890083
73MAPK150.77876528
74INSRR0.77125010
75RET0.73661431
76CAMKK20.72735442
77LMTK20.72273754
78ERBB40.71452629
79RIPK10.71406812
80DYRK1A0.69582267
81PRKCH0.68433520
82ERBB30.68357184
83CAMK10.68262119
84PLK20.66968427
85TAOK20.66587173
86MAP3K20.66194168
87CSNK1G30.65933525
88STK110.65032064
89RPS6KB10.64941567
90DYRK20.64860757
91RAF10.64024811
92GRK10.63795036
93CAMK2A0.62301188
94WNK40.61553323
95JAK20.61293554
96CSNK1G10.59818974
97FYN0.58354266
98SGK10.57749748
99PRKCI0.57428219
100TRIM280.55693860
101MAPK100.52962189
102PAK30.52588373
103CAMK1D0.52542036
104CSNK1A1L0.52432097
105CSNK1G20.51723161
106PDK20.50256265
107BRSK10.49323128
108PRKAA10.48586951
109RPS6KA30.47992784
110TAOK30.47343580
111CAMK40.47302509
112FER0.47116527
113TNK20.46365077
114ALK0.46348980
115RPS6KA20.45285214
116PRKACA0.45271411
117PRKCE0.45023843
118CAMK2B0.44229279
119MKNK20.44195842
120GRK50.44012142
121SGK20.43830325
122DYRK1B0.43650961
123PIK3CA0.43011459
124PRKCA0.42494992
125RPS6KA10.42063310
126CAMK1G0.40531858
127CASK0.38853009
128ROCK10.38763448
129PDPK10.38494461
130SGK30.38256695
131CDC42BPA0.38247383
132OXSR10.37616173
133IRAK20.36783332
134MAP3K70.36369360
135MAPK90.36323060
136PRKCB0.35197221
137PRKD10.34431558
138MAP2K10.34325803
139STK38L0.34311786
140PRKACG0.31998332
141FGFR10.31812666
142LATS20.31531700
143PDK10.30789667
144MAPK80.30539558
145DDR20.30441169
146NUAK10.29957685
147CSNK1D0.29756582
148GSK3B0.29058329
149PRKCD0.28352579
150PLK40.27109409
151PRKCQ0.27042123

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.41991022
2One carbon pool by folate_Homo sapiens_hsa006703.29353741
3Olfactory transduction_Homo sapiens_hsa047403.22451846
4Synaptic vesicle cycle_Homo sapiens_hsa047213.19357547
5GABAergic synapse_Homo sapiens_hsa047273.06040368
6Morphine addiction_Homo sapiens_hsa050322.88216556
7Arginine biosynthesis_Homo sapiens_hsa002202.71691007
8Circadian entrainment_Homo sapiens_hsa047132.66286749
9Cocaine addiction_Homo sapiens_hsa050302.50942372
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.48772618
11Glutamatergic synapse_Homo sapiens_hsa047242.48242213
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.46929743
13Dopaminergic synapse_Homo sapiens_hsa047282.36775162
14Sulfur relay system_Homo sapiens_hsa041222.27556156
15Cholinergic synapse_Homo sapiens_hsa047252.26134019
16Amphetamine addiction_Homo sapiens_hsa050312.21475172
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98273358
18Phototransduction_Homo sapiens_hsa047441.98154456
19Long-term potentiation_Homo sapiens_hsa047201.96670633
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85261097
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.84808683
22Salivary secretion_Homo sapiens_hsa049701.82196646
23Insulin secretion_Homo sapiens_hsa049111.81566462
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76197570
25Renin secretion_Homo sapiens_hsa049241.74524912
26Oxytocin signaling pathway_Homo sapiens_hsa049211.71332524
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65828853
28Gap junction_Homo sapiens_hsa045401.63465257
29Selenocompound metabolism_Homo sapiens_hsa004501.62677546
30Serotonergic synapse_Homo sapiens_hsa047261.60872284
31Sulfur metabolism_Homo sapiens_hsa009201.60005880
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54268563
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52934373
34Gastric acid secretion_Homo sapiens_hsa049711.47213891
35Taste transduction_Homo sapiens_hsa047421.44027352
36Calcium signaling pathway_Homo sapiens_hsa040201.42760196
37Axon guidance_Homo sapiens_hsa043601.31427594
38GnRH signaling pathway_Homo sapiens_hsa049121.28388094
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27300332
40Long-term depression_Homo sapiens_hsa047301.25212828
41cAMP signaling pathway_Homo sapiens_hsa040241.24759294
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23986026
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.19470676
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.16203991
45Nitrogen metabolism_Homo sapiens_hsa009101.16136254
46* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14923473
47Ether lipid metabolism_Homo sapiens_hsa005651.06651764
48Regulation of autophagy_Homo sapiens_hsa041401.06575307
49Glioma_Homo sapiens_hsa052141.05598754
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02733250
51Type II diabetes mellitus_Homo sapiens_hsa049301.01035065
52ErbB signaling pathway_Homo sapiens_hsa040121.00473719
53Cardiac muscle contraction_Homo sapiens_hsa042601.00028486
54Alcoholism_Homo sapiens_hsa050340.98407873
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97915548
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.96579421
57Fatty acid biosynthesis_Homo sapiens_hsa000610.96256631
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96241497
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95346336
60Oocyte meiosis_Homo sapiens_hsa041140.94345984
61Collecting duct acid secretion_Homo sapiens_hsa049660.93743810
62Linoleic acid metabolism_Homo sapiens_hsa005910.93680264
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93610668
64Dilated cardiomyopathy_Homo sapiens_hsa054140.92014432
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90112754
66Estrogen signaling pathway_Homo sapiens_hsa049150.87104201
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86557732
68Melanogenesis_Homo sapiens_hsa049160.84587098
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.82933262
70Biosynthesis of amino acids_Homo sapiens_hsa012300.82467718
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80961393
72ABC transporters_Homo sapiens_hsa020100.78875475
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.78344429
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76041684
75Choline metabolism in cancer_Homo sapiens_hsa052310.75539734
76Arginine and proline metabolism_Homo sapiens_hsa003300.74599347
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73083925
78mTOR signaling pathway_Homo sapiens_hsa041500.71744311
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70879307
80Circadian rhythm_Homo sapiens_hsa047100.70740694
81MAPK signaling pathway_Homo sapiens_hsa040100.68804015
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.68550047
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68519976
84Non-small cell lung cancer_Homo sapiens_hsa052230.67703918
85Vibrio cholerae infection_Homo sapiens_hsa051100.67637432
86Galactose metabolism_Homo sapiens_hsa000520.66321806
87Propanoate metabolism_Homo sapiens_hsa006400.65631166
88VEGF signaling pathway_Homo sapiens_hsa043700.65248302
89Endometrial cancer_Homo sapiens_hsa052130.65212788
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63883234
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63144914
92Rap1 signaling pathway_Homo sapiens_hsa040150.63003034
93Retinol metabolism_Homo sapiens_hsa008300.61222312
94mRNA surveillance pathway_Homo sapiens_hsa030150.61201408
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60912499
96Pancreatic secretion_Homo sapiens_hsa049720.60691463
97Endocytosis_Homo sapiens_hsa041440.59491177
98Renal cell carcinoma_Homo sapiens_hsa052110.59304526
99Type I diabetes mellitus_Homo sapiens_hsa049400.59120774
100Ras signaling pathway_Homo sapiens_hsa040140.57854414
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57541013
102Dorso-ventral axis formation_Homo sapiens_hsa043200.57490003
103Vitamin digestion and absorption_Homo sapiens_hsa049770.56959074
104Peroxisome_Homo sapiens_hsa041460.54284355
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52612597
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51717530
107Thyroid hormone synthesis_Homo sapiens_hsa049180.50864761
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.50747760
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50540311
110Butanoate metabolism_Homo sapiens_hsa006500.50063362
111Inositol phosphate metabolism_Homo sapiens_hsa005620.49447918
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49309514
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49142935
114Chemokine signaling pathway_Homo sapiens_hsa040620.48409928
115Prion diseases_Homo sapiens_hsa050200.48339532
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48319626
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47287012
118Basal transcription factors_Homo sapiens_hsa030220.46894556
119Sphingolipid metabolism_Homo sapiens_hsa006000.46781631
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45395819
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43032166
122Bile secretion_Homo sapiens_hsa049760.42892720
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42650986
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42175865
125Fanconi anemia pathway_Homo sapiens_hsa034600.41386864
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41204695
127Mineral absorption_Homo sapiens_hsa049780.41003399
128Fatty acid metabolism_Homo sapiens_hsa012120.40051684
129Insulin signaling pathway_Homo sapiens_hsa049100.38779492
130Glucagon signaling pathway_Homo sapiens_hsa049220.37971167
131Wnt signaling pathway_Homo sapiens_hsa043100.37681918
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36801838
133Tryptophan metabolism_Homo sapiens_hsa003800.36258076
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35508361
135Colorectal cancer_Homo sapiens_hsa052100.34557847
136Oxidative phosphorylation_Homo sapiens_hsa001900.33931832
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.33854960
138Ovarian steroidogenesis_Homo sapiens_hsa049130.32900206
139Fat digestion and absorption_Homo sapiens_hsa049750.31642935
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31596086
141Metabolic pathways_Homo sapiens_hsa011000.29803586
142Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28812926
143AMPK signaling pathway_Homo sapiens_hsa041520.27673068
144PPAR signaling pathway_Homo sapiens_hsa033200.27541755
145Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25144096
146Folate biosynthesis_Homo sapiens_hsa007900.23577040

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