Rank | Gene Set | Z-score |
---|---|---|
1 | muscle filament sliding (GO:0030049) | 9.55961627 |
2 | actin-myosin filament sliding (GO:0033275) | 9.55961627 |
3 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 9.18368740 |
4 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 7.86425030 |
5 | actin-mediated cell contraction (GO:0070252) | 7.68428665 |
6 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 7.67483725 |
7 | striated muscle atrophy (GO:0014891) | 7.67054103 |
8 | sarcomere organization (GO:0045214) | 7.45389443 |
9 | muscle atrophy (GO:0014889) | 7.36783471 |
10 | potassium ion export (GO:0071435) | 7.31101977 |
11 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 7.26482106 |
12 | cardiac muscle contraction (GO:0060048) | 7.15842392 |
13 | cardiac myofibril assembly (GO:0055003) | 6.91528513 |
14 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 6.73935664 |
15 | skeletal muscle adaptation (GO:0043501) | 6.72409345 |
16 | negative regulation of protein localization to cell surface (GO:2000009) | 6.63177718 |
17 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 6.55703951 |
18 | cardiac muscle tissue morphogenesis (GO:0055008) | 6.50227726 |
19 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 6.32209065 |
20 | detection of calcium ion (GO:0005513) | 6.07898482 |
21 | positive regulation of ATPase activity (GO:0032781) | 6.00764971 |
22 | positive regulation of ATP catabolic process (GO:1903291) | 6.00764971 |
23 | pinocytosis (GO:0006907) | 5.96410218 |
24 | regulation of actin filament-based movement (GO:1903115) | 5.77039683 |
25 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 5.75878069 |
26 | actin filament-based movement (GO:0030048) | 5.74310932 |
27 | muscle tissue morphogenesis (GO:0060415) | 5.70089227 |
28 | actomyosin structure organization (GO:0031032) | 5.49219389 |
29 | myofibril assembly (GO:0030239) | 5.34023318 |
30 | response to redox state (GO:0051775) | 5.19359740 |
31 | regulation of striated muscle contraction (GO:0006942) | 4.86491437 |
32 | cellular response to epinephrine stimulus (GO:0071872) | 4.86476964 |
33 | regulation of ATPase activity (GO:0043462) | 4.85065342 |
34 | regulation of ATP catabolic process (GO:1903289) | 4.85065342 |
35 | ventricular cardiac muscle cell action potential (GO:0086005) | 4.84530450 |
36 | negative regulation of potassium ion transport (GO:0043267) | 4.64055435 |
37 | striated muscle contraction (GO:0006941) | 4.63437521 |
38 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 4.56272224 |
39 | response to epinephrine (GO:0071871) | 4.50756985 |
40 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 4.50750453 |
41 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 4.45571036 |
42 | calcium-mediated signaling using intracellular calcium source (GO:0035584) | 4.18269213 |
43 | response to caffeine (GO:0031000) | 4.11998545 |
44 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 4.04438558 |
45 | negative regulation of fatty acid biosynthetic process (GO:0045717) | 3.99041912 |
46 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 3.86139072 |
47 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.64473143 |
48 | regulation of membrane repolarization (GO:0060306) | 3.61929721 |
49 | adenosine receptor signaling pathway (GO:0001973) | 3.60868500 |
50 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 3.60602852 |
51 | cardiac muscle cell action potential (GO:0086001) | 3.51125797 |
52 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.48041648 |
53 | negative regulation of myeloid cell apoptotic process (GO:0033033) | 3.44168635 |
54 | atrial cardiac muscle cell action potential (GO:0086014) | 3.38291395 |
55 | protein neddylation (GO:0045116) | 3.36801218 |
56 | cell communication by electrical coupling (GO:0010644) | 3.35534503 |
57 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 3.33663012 |
58 | regulation of cell communication by electrical coupling (GO:0010649) | 3.28867498 |
59 | toxin metabolic process (GO:0009404) | 3.27984846 |
60 | virion attachment to host cell (GO:0019062) | 3.16562727 |
61 | adhesion of symbiont to host cell (GO:0044650) | 3.16562727 |
62 | fatty acid beta-oxidation (GO:0006635) | 3.13078979 |
63 | regulation of muscle contraction (GO:0006937) | 3.12211446 |
64 | regulation of type B pancreatic cell apoptotic process (GO:2000674) | 3.11927044 |
65 | base-excision repair, AP site formation (GO:0006285) | 3.09958841 |
66 | muscle contraction (GO:0006936) | 3.06677590 |
67 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.03807216 |
68 | muscle adaptation (GO:0043500) | 3.03667085 |
69 | cellular response to dexamethasone stimulus (GO:0071549) | 3.02858954 |
70 | immunoglobulin mediated immune response (GO:0016064) | 3.01767901 |
71 | positive regulation of potassium ion transport (GO:0043268) | 3.01547177 |
72 | mitochondrial fusion (GO:0008053) | 3.01337164 |
73 | regulation of heart contraction (GO:0008016) | 2.98880214 |
74 | cardiac muscle hypertrophy (GO:0003300) | 2.97367582 |
75 | hydrogen peroxide biosynthetic process (GO:0050665) | 2.92061159 |
76 | muscle hypertrophy (GO:0014896) | 2.90793595 |
77 | regulation of heart rate (GO:0002027) | 2.85520369 |
78 | positive regulation of ion transmembrane transporter activity (GO:0032414) | 2.85517334 |
79 | response to dexamethasone (GO:0071548) | 2.84195462 |
80 | adrenergic receptor signaling pathway (GO:0071875) | 2.82716560 |
81 | adhesion of symbiont to host (GO:0044406) | 2.81446607 |
82 | regulation of protein localization to cell surface (GO:2000008) | 2.79806893 |
83 | positive regulation of heart rate (GO:0010460) | 2.77740253 |
84 | striated muscle hypertrophy (GO:0014897) | 2.77423163 |
85 | nerve growth factor signaling pathway (GO:0038180) | 2.71192584 |
86 | striated muscle adaptation (GO:0014888) | 2.70204719 |
87 | muscle system process (GO:0003012) | 2.69345159 |
88 | cell communication involved in cardiac conduction (GO:0086065) | 2.65978289 |
89 | 3-UTR-mediated mRNA stabilization (GO:0070935) | 2.65563499 |
90 | regulation of synapse structural plasticity (GO:0051823) | 2.65510878 |
91 | regulation of muscle system process (GO:0090257) | 2.61834072 |
92 | focal adhesion assembly (GO:0048041) | 2.60157050 |
93 | cell-substrate adherens junction assembly (GO:0007045) | 2.60157050 |
94 | cellular response to virus (GO:0098586) | 2.58254883 |
95 | short-term memory (GO:0007614) | 2.51095888 |
96 | reactive oxygen species biosynthetic process (GO:1903409) | 2.50992673 |
97 | positive regulation of transporter activity (GO:0032411) | 2.50751865 |
98 | positive regulation of cation channel activity (GO:2001259) | 2.46201816 |
99 | heart process (GO:0003015) | 12.8846526 |
100 | heart contraction (GO:0060047) | 12.8846526 |
Rank | Gene Set | Z-score |
---|---|---|
1 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 5.91665367 |
2 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 5.19130798 |
3 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 4.56481288 |
4 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.09961437 |
5 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.58771235 |
6 | HTT_18923047_ChIP-ChIP_STHdh_Human | 2.51701536 |
7 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.50184414 |
8 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.49025354 |
9 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.40427420 |
10 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 2.38533454 |
11 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 2.35851152 |
12 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 2.35851152 |
13 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.23266567 |
14 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 2.22206073 |
15 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.15805215 |
16 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 2.14979440 |
17 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 2.13200497 |
18 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 2.12091262 |
19 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.06841429 |
20 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.06835216 |
21 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 2.06701862 |
22 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.02341223 |
23 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.93230686 |
24 | GATA1_22025678_ChIP-Seq_K562_Human | 1.91728096 |
25 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.85195161 |
26 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.85157375 |
27 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.73247070 |
28 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.72152474 |
29 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.67194868 |
30 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.64478471 |
31 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.64038012 |
32 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.61298502 |
33 | SPI1_23127762_ChIP-Seq_K562_Human | 1.60295330 |
34 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.60075736 |
35 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.59659029 |
36 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.57117789 |
37 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.56592757 |
38 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.56589983 |
39 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.55189378 |
40 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.54603582 |
41 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.54565429 |
42 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.53806813 |
43 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.52100907 |
44 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.48755757 |
45 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.48661539 |
46 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.46181837 |
47 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.44390474 |
48 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.42796520 |
49 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.38584186 |
50 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.36022196 |
51 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.35999614 |
52 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.34844078 |
53 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.34740272 |
54 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.33646655 |
55 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.32642919 |
56 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.30736248 |
57 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.30425057 |
58 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.28668346 |
59 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.25605976 |
60 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.24681663 |
61 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.23309674 |
62 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.21778525 |
63 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.21220030 |
64 | ATF3_27146783_Chip-Seq_COLON_Human | 1.20926575 |
65 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.13346947 |
66 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.13244920 |
67 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.12420269 |
68 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.12254269 |
69 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.09192825 |
70 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.08391799 |
71 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.08071522 |
72 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.07868791 |
73 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.07483060 |
74 | CTCF_21964334_Chip-Seq_Bcells_Human | 1.05486718 |
75 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.03634553 |
76 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.03157162 |
77 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.02298644 |
78 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 1.01166753 |
79 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.01114084 |
80 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.99997118 |
81 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.98870165 |
82 | * E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.98257172 |
83 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.98239063 |
84 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.97589138 |
85 | MAF_26560356_Chip-Seq_TH1_Human | 0.97224819 |
86 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.95613685 |
87 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.94681975 |
88 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.94016466 |
89 | SOX2_21211035_ChIP-Seq_LN229_Human | 0.93141683 |
90 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.93015316 |
91 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.92811577 |
92 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.91914407 |
93 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.90362528 |
94 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.88756160 |
95 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.88457229 |
96 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.86879271 |
97 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.85509781 |
98 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 0.85204302 |
99 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.84972142 |
100 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.83269242 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002837_dystrophic_cardiac_calcinosis | 9.58688545 |
2 | MP0004084_abnormal_cardiac_muscle | 7.31744139 |
3 | MP0004215_abnormal_myocardial_fiber | 5.71258425 |
4 | MP0004036_abnormal_muscle_relaxation | 4.76089143 |
5 | MP0003646_muscle_fatigue | 4.36510000 |
6 | MP0005330_cardiomyopathy | 3.66909877 |
7 | MP0003828_pulmonary_edema | 3.48810816 |
8 | MP0003137_abnormal_impulse_conducting | 3.43255224 |
9 | MP0004510_myositis | 3.12576612 |
10 | MP0000751_myopathy | 2.64328003 |
11 | MP0009840_abnormal_foam_cell | 2.53766115 |
12 | MP0006138_congestive_heart_failure | 2.40633601 |
13 | MP0008004_abnormal_stomach_pH | 2.33505115 |
14 | MP0002972_abnormal_cardiac_muscle | 2.31651841 |
15 | MP0005451_abnormal_body_composition | 2.29275972 |
16 | MP0008775_abnormal_heart_ventricle | 2.17549398 |
17 | MP0002254_reproductive_system_inflammat | 2.02253786 |
18 | MP0004087_abnormal_muscle_fiber | 1.98463186 |
19 | MP0002269_muscular_atrophy | 1.94668215 |
20 | MP0005666_abnormal_adipose_tissue | 1.90758432 |
21 | MP0002127_abnormal_cardiovascular_syste | 1.83910722 |
22 | MP0000343_altered_response_to | 1.71368757 |
23 | MP0005620_abnormal_muscle_contractility | 1.69007085 |
24 | MP0005385_cardiovascular_system_phenoty | 1.67266811 |
25 | MP0001544_abnormal_cardiovascular_syste | 1.67266811 |
26 | MP0000749_muscle_degeneration | 1.64831344 |
27 | MP0010630_abnormal_cardiac_muscle | 1.61879556 |
28 | MP0004085_abnormal_heartbeat | 1.54156737 |
29 | MP0005670_abnormal_white_adipose | 1.49511657 |
30 | MP0006036_abnormal_mitochondrial_physio | 1.36116107 |
31 | MP0002332_abnormal_exercise_endurance | 1.31368105 |
32 | MP0005058_abnormal_lysosome_morphology | 1.21608921 |
33 | MP0008438_abnormal_cutaneous_collagen | 1.20796404 |
34 | MP0003195_calcinosis | 1.17802129 |
35 | MP0005375_adipose_tissue_phenotype | 1.14885813 |
36 | MP0005167_abnormal_blood-brain_barrier | 1.00810730 |
37 | MP0003136_yellow_coat_color | 0.96499172 |
38 | MP0004185_abnormal_adipocyte_glucose | 0.95777491 |
39 | MP0004145_abnormal_muscle_electrophysio | 0.95357451 |
40 | MP0003221_abnormal_cardiomyocyte_apopto | 0.95065775 |
41 | MP0000372_irregular_coat_pigmentation | 0.92601824 |
42 | MP0005165_increased_susceptibility_to | 0.90806543 |
43 | MP0003303_peritoneal_inflammation | 0.88517444 |
44 | MP0002148_abnormal_hypersensitivity_rea | 0.88231731 |
45 | MP0000759_abnormal_skeletal_muscle | 0.88040468 |
46 | MP0000747_muscle_weakness | 0.87442215 |
47 | MP0001727_abnormal_embryo_implantation | 0.86809926 |
48 | MP0004484_altered_response_of | 0.86709632 |
49 | MP0004130_abnormal_muscle_cell | 0.84015847 |
50 | MP0002106_abnormal_muscle_physiology | 0.83663446 |
51 | MP0005266_abnormal_metabolism | 0.75975130 |
52 | MP0005275_abnormal_skin_tensile | 0.71780726 |
53 | MP0008961_abnormal_basal_metabolism | 0.71594747 |
54 | MP0005647_abnormal_sex_gland | 0.70652221 |
55 | MP0003806_abnormal_nucleotide_metabolis | 0.69012077 |
56 | MP0000003_abnormal_adipose_tissue | 0.67211946 |
57 | MP0003186_abnormal_redox_activity | 0.65176060 |
58 | MP0003693_abnormal_embryo_hatching | 0.63338248 |
59 | MP0003075_altered_response_to | 0.63024351 |
60 | MP0008260_abnormal_autophagy | 0.62953085 |
61 | MP0006082_CNS_inflammation | 0.62754944 |
62 | MP0002090_abnormal_vision | 0.61683262 |
63 | MP0002998_abnormal_bone_remodeling | 0.61363724 |
64 | MP0003329_amyloid_beta_deposits | 0.59615906 |
65 | MP0005369_muscle_phenotype | 0.59322140 |
66 | MP0000685_abnormal_immune_system | 0.57643210 |
67 | MP0000604_amyloidosis | 0.57231308 |
68 | MP0003634_abnormal_glial_cell | 0.53595546 |
69 | MP0009785_altered_susceptibility_to | 0.52910535 |
70 | MP0000266_abnormal_heart_morphology | 0.50854045 |
71 | MP0005025_abnormal_response_to | 0.48789976 |
72 | MP0005408_hypopigmentation | 0.47713124 |
73 | MP0006035_abnormal_mitochondrial_morpho | 0.46325331 |
74 | MP0005535_abnormal_body_temperature | 0.44469005 |
75 | MP0000013_abnormal_adipose_tissue | 0.43994710 |
76 | MP0000750_abnormal_muscle_regeneration | 0.41548601 |
77 | MP0001790_abnormal_immune_system | 0.38258301 |
78 | MP0005387_immune_system_phenotype | 0.38258301 |
79 | MP0006072_abnormal_retinal_apoptosis | 0.38114181 |
80 | MP0002139_abnormal_hepatobiliary_system | 0.35637073 |
81 | MP0000358_abnormal_cell_content/ | 0.35526621 |
82 | MP0002419_abnormal_innate_immunity | 0.34888064 |
83 | MP0005166_decreased_susceptibility_to | 0.33139933 |
84 | MP0005410_abnormal_fertilization | 0.32576561 |
85 | MP0001873_stomach_inflammation | 0.32544118 |
86 | MP0000858_altered_metastatic_potential | 0.32450449 |
87 | MP0000249_abnormal_blood_vessel | 0.32058511 |
88 | MP0002128_abnormal_blood_circulation | 0.31859946 |
89 | MP0002088_abnormal_embryonic_growth/wei | 0.29923764 |
90 | MP0009278_abnormal_bone_marrow | 0.29703643 |
91 | MP0008874_decreased_physiological_sensi | 0.29453583 |
92 | MP0003984_embryonic_growth_retardation | 0.29098098 |
93 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.27585596 |
94 | MP0001784_abnormal_fluid_regulation | 0.26369944 |
95 | MP0002452_abnormal_antigen_presenting | 0.26144792 |
96 | MP0009764_decreased_sensitivity_to | 0.25551322 |
97 | MP0000767_abnormal_smooth_muscle | 0.24330931 |
98 | MP0002723_abnormal_immune_serum | 0.23534464 |
99 | MP0002876_abnormal_thyroid_physiology | 0.23165247 |
100 | MP0005253_abnormal_eye_physiology | 0.22899032 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Sudden death (HP:0001699) | 9.40972520 |
2 | Ventricular tachycardia (HP:0004756) | 8.99221926 |
3 | Right ventricular cardiomyopathy (HP:0011663) | 7.60013442 |
4 | Atrial fibrillation (HP:0005110) | 6.48686848 |
5 | Supraventricular tachycardia (HP:0004755) | 5.86257101 |
6 | Generalized aminoaciduria (HP:0002909) | 5.86208514 |
7 | Primary atrial arrhythmia (HP:0001692) | 5.84186870 |
8 | Lipoatrophy (HP:0100578) | 5.72959896 |
9 | Supraventricular arrhythmia (HP:0005115) | 5.67794423 |
10 | Nausea (HP:0002018) | 5.48839407 |
11 | Exercise-induced myalgia (HP:0003738) | 5.38503052 |
12 | Syncope (HP:0001279) | 5.23604115 |
13 | Dilated cardiomyopathy (HP:0001644) | 5.03108616 |
14 | Ventricular arrhythmia (HP:0004308) | 3.90723871 |
15 | Hyporeflexia of lower limbs (HP:0002600) | 3.87790875 |
16 | Proximal tubulopathy (HP:0000114) | 3.82424113 |
17 | Hypoglycemic coma (HP:0001325) | 3.81112164 |
18 | Limb-girdle muscle atrophy (HP:0003797) | 3.71717682 |
19 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.66558496 |
20 | Renal cortical cysts (HP:0000803) | 3.60504277 |
21 | Prolonged QT interval (HP:0001657) | 3.59092320 |
22 | Bundle branch block (HP:0011710) | 3.53511408 |
23 | Myoglobinuria (HP:0002913) | 3.36608178 |
24 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 3.28044191 |
25 | Dicarboxylic aciduria (HP:0003215) | 3.28044191 |
26 | EMG: myopathic abnormalities (HP:0003458) | 3.06443519 |
27 | Abnormality of the calf musculature (HP:0001430) | 3.03317680 |
28 | Frequent falls (HP:0002359) | 3.01798066 |
29 | Abnormality of glycolipid metabolism (HP:0010969) | 3.00209995 |
30 | Abnormality of liposaccharide metabolism (HP:0010968) | 3.00209995 |
31 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 3.00209995 |
32 | Resting tremor (HP:0002322) | 2.95317343 |
33 | Atrioventricular block (HP:0001678) | 2.92649425 |
34 | Muscle fiber splitting (HP:0003555) | 2.91094156 |
35 | Tongue fasciculations (HP:0001308) | 2.88657727 |
36 | Hepatic necrosis (HP:0002605) | 2.87259051 |
37 | Exercise-induced muscle cramps (HP:0003710) | 2.75018842 |
38 | Neonatal death (HP:0003811) | 2.73960944 |
39 | Abnormal EKG (HP:0003115) | 2.67805005 |
40 | Muscle fibrillation (HP:0010546) | 2.65564478 |
41 | Rhabdomyolysis (HP:0003201) | 2.60773703 |
42 | Agnosia (HP:0010524) | 2.52377476 |
43 | Left ventricular hypertrophy (HP:0001712) | 2.51797876 |
44 | Asymmetric septal hypertrophy (HP:0001670) | 2.51185725 |
45 | Hypokinesia (HP:0002375) | 2.48962395 |
46 | Palpitations (HP:0001962) | 2.47251900 |
47 | Multiple enchondromatosis (HP:0005701) | 2.47040426 |
48 | Progressive muscle weakness (HP:0003323) | 2.43998610 |
49 | Neck muscle weakness (HP:0000467) | 2.38156900 |
50 | Palmoplantar keratoderma (HP:0000982) | 2.33960494 |
51 | Ragged-red muscle fibers (HP:0003200) | 2.31515497 |
52 | Abnormality of the foot musculature (HP:0001436) | 2.27353841 |
53 | Abnormal atrioventricular conduction (HP:0005150) | 2.25419818 |
54 | Heart block (HP:0012722) | 2.24531052 |
55 | Foot dorsiflexor weakness (HP:0009027) | 2.23332977 |
56 | Fasciculations (HP:0002380) | 2.18872038 |
57 | Abnormality of the vocal cords (HP:0008777) | 2.17985446 |
58 | Skin nodule (HP:0200036) | 2.16469622 |
59 | Increased variability in muscle fiber diameter (HP:0003557) | 2.15983268 |
60 | Distal upper limb amyotrophy (HP:0007149) | 2.14910595 |
61 | Upper limb amyotrophy (HP:0009129) | 2.14910595 |
62 | Glycosuria (HP:0003076) | 2.10387238 |
63 | Abnormality of urine glucose concentration (HP:0011016) | 2.10387238 |
64 | Sudden cardiac death (HP:0001645) | 2.10079094 |
65 | Increased cerebral lipofuscin (HP:0011813) | 2.04889036 |
66 | Scapular winging (HP:0003691) | 2.04314458 |
67 | Axonal loss (HP:0003447) | 2.00724211 |
68 | Increased connective tissue (HP:0009025) | 1.98414356 |
69 | Reduced antithrombin III activity (HP:0001976) | 1.97724601 |
70 | Cerebral edema (HP:0002181) | 1.96935579 |
71 | Hand muscle atrophy (HP:0009130) | 1.95729287 |
72 | Papilledema (HP:0001085) | 1.92468312 |
73 | Disinhibition (HP:0000734) | 1.90647544 |
74 | Abnormality of skeletal muscle fiber size (HP:0012084) | 1.88223021 |
75 | Biliary tract neoplasm (HP:0100574) | 1.87243243 |
76 | Recurrent gram-negative bacterial infections (HP:0005420) | 1.84629181 |
77 | Tinnitus (HP:0000360) | 1.81682544 |
78 | Pulmonary fibrosis (HP:0002206) | 1.76773859 |
79 | Global brain atrophy (HP:0002283) | 1.73729840 |
80 | Bulbar palsy (HP:0001283) | 1.73336694 |
81 | Renal Fanconi syndrome (HP:0001994) | 1.72872482 |
82 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 1.71069440 |
83 | Distal lower limb muscle weakness (HP:0009053) | 1.70721151 |
84 | Athetosis (HP:0002305) | 1.70491209 |
85 | Increased serum pyruvate (HP:0003542) | 1.70200479 |
86 | Acute necrotizing encephalopathy (HP:0006965) | 1.69806450 |
87 | Ventricular fibrillation (HP:0001663) | 1.65939892 |
88 | Abnormality of the left ventricular outflow tract (HP:0011103) | 1.64080296 |
89 | Subaortic stenosis (HP:0001682) | 1.64080296 |
90 | Lymphangioma (HP:0100764) | 1.62674436 |
91 | Impaired proprioception (HP:0010831) | 1.61862918 |
92 | Upper motor neuron abnormality (HP:0002127) | 1.61324011 |
93 | Gastrointestinal stroma tumor (HP:0100723) | 1.61020845 |
94 | Exercise intolerance (HP:0003546) | 1.58983361 |
95 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.56957382 |
96 | Congestive heart failure (HP:0001635) | 1.56072787 |
97 | Metaphyseal cupping (HP:0003021) | 1.54841953 |
98 | Respiratory distress (HP:0002098) | 1.53509570 |
99 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.53186989 |
100 | Impaired pain sensation (HP:0007328) | 1.53057086 |
Rank | Gene Set | Z-score |
---|---|---|
1 | CDC42BPA | 6.14579150 |
2 | STK16 | 4.94478834 |
3 | DAPK3 | 4.88529437 |
4 | MAP3K5 | 4.02163131 |
5 | TAOK1 | 3.30584875 |
6 | DMPK | 2.93256937 |
7 | TBK1 | 2.73802120 |
8 | ROCK1 | 2.63584791 |
9 | NEK9 | 2.44749405 |
10 | PLK4 | 2.18676587 |
11 | ERN1 | 2.08022676 |
12 | PINK1 | 2.01341438 |
13 | PIM2 | 1.97092524 |
14 | VRK2 | 1.75358298 |
15 | IRAK3 | 1.70066349 |
16 | ARAF | 1.68995027 |
17 | MAPK12 | 1.67674110 |
18 | TGFBR2 | 1.63575638 |
19 | MAPKAPK3 | 1.61060743 |
20 | MUSK | 1.58697684 |
21 | PRKD1 | 1.43366393 |
22 | IKBKE | 1.43278448 |
23 | TIE1 | 1.38559169 |
24 | PRKAA2 | 1.33308340 |
25 | CAMK2D | 1.33123764 |
26 | UHMK1 | 1.27491902 |
27 | KDR | 1.23101870 |
28 | CAMKK2 | 1.22119031 |
29 | MAP3K11 | 1.21550487 |
30 | PRKG2 | 1.13179839 |
31 | PRKCE | 1.07751006 |
32 | ACVR1B | 1.02328483 |
33 | MAP3K3 | 1.01772086 |
34 | ABL2 | 1.00883146 |
35 | BCKDK | 0.99924821 |
36 | TTN | 0.99442725 |
37 | RAF1 | 0.99389248 |
38 | LMTK2 | 0.94269224 |
39 | MYLK | 0.86248929 |
40 | BRSK2 | 0.84242540 |
41 | TTK | 0.83740609 |
42 | BLK | 0.79617383 |
43 | RPS6KA1 | 0.77862755 |
44 | PRKCH | 0.76660068 |
45 | CDK12 | 0.76418015 |
46 | RPS6KC1 | 0.76099046 |
47 | RPS6KL1 | 0.76099046 |
48 | RPS6KA2 | 0.75653597 |
49 | NME2 | 0.73889287 |
50 | IRAK2 | 0.71743332 |
51 | RIPK4 | 0.71112930 |
52 | BRAF | 0.67078295 |
53 | CAMK2A | 0.66692338 |
54 | EEF2K | 0.66397336 |
55 | MAPK4 | 0.66209092 |
56 | TYRO3 | 0.65828856 |
57 | GRK7 | 0.62057664 |
58 | RPS6KA6 | 0.61717824 |
59 | MAP4K2 | 0.61419726 |
60 | SMG1 | 0.60928153 |
61 | PRKACG | 0.60214288 |
62 | DDR2 | 0.58799463 |
63 | TAOK2 | 0.55775027 |
64 | OBSCN | 0.55208991 |
65 | CAMK1G | 0.54465662 |
66 | SCYL2 | 0.53918877 |
67 | PAK6 | 0.52427004 |
68 | ROCK2 | 0.51994967 |
69 | ERBB3 | 0.51573125 |
70 | MAP2K3 | 0.49006448 |
71 | AKT2 | 0.48804478 |
72 | PRKG1 | 0.48538740 |
73 | PRKAA1 | 0.47730588 |
74 | KSR2 | 0.42308313 |
75 | MTOR | 0.42179094 |
76 | MAP2K1 | 0.40670505 |
77 | CCNB1 | 0.39676320 |
78 | MAPKAPK2 | 0.35934880 |
79 | MST1R | 0.35457618 |
80 | CAMK1D | 0.33163426 |
81 | BRSK1 | 0.33005810 |
82 | PRKACA | 0.31502375 |
83 | PAK3 | 0.31154420 |
84 | SGK2 | 0.29757729 |
85 | CSF1R | 0.29308149 |
86 | PRKACB | 0.29099926 |
87 | PRKD2 | 0.28019686 |
88 | PDGFRA | 0.27869609 |
89 | STK4 | 0.25587236 |
90 | RIPK1 | 0.22855480 |
91 | WEE1 | 0.20716796 |
92 | AKT1 | 0.19658409 |
93 | PRKCD | 0.19063244 |
94 | SGK3 | 0.18883666 |
95 | MAPK10 | 0.17783159 |
96 | DAPK2 | 0.17654739 |
97 | STK11 | 0.17173940 |
98 | PIK3CA | 0.16567406 |
99 | CHUK | 0.16107466 |
100 | RPS6KA3 | 0.15106788 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 6.50606844 |
2 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 5.92357471 |
3 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 5.85402171 |
4 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 3.42333434 |
5 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.83915874 |
6 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.45189515 |
7 | Lysosome_Homo sapiens_hsa04142 | 2.16661224 |
8 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.91188969 |
9 | Parkinsons disease_Homo sapiens_hsa05012 | 1.72737868 |
10 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.68336226 |
11 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.63433129 |
12 | Carbon metabolism_Homo sapiens_hsa01200 | 1.57142749 |
13 | Other glycan degradation_Homo sapiens_hsa00511 | 1.43764355 |
14 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.33551998 |
15 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.30564485 |
16 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.29091804 |
17 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.24608843 |
18 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.19064169 |
19 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.15901322 |
20 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.15158715 |
21 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.14405113 |
22 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.12951513 |
23 | Sulfur relay system_Homo sapiens_hsa04122 | 1.10533448 |
24 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.09556472 |
25 | Asthma_Homo sapiens_hsa05310 | 1.07381695 |
26 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.02475486 |
27 | Focal adhesion_Homo sapiens_hsa04510 | 0.98192980 |
28 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.93253493 |
29 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.91129541 |
30 | Alzheimers disease_Homo sapiens_hsa05010 | 0.90611425 |
31 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.88869433 |
32 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.84458085 |
33 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.84335826 |
34 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.83355817 |
35 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.83097183 |
36 | Amoebiasis_Homo sapiens_hsa05146 | 0.81926696 |
37 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.81230786 |
38 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.80005389 |
39 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.79971047 |
40 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.78540549 |
41 | Base excision repair_Homo sapiens_hsa03410 | 0.78496478 |
42 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.75740145 |
43 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.74189765 |
44 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.73642584 |
45 | Renin secretion_Homo sapiens_hsa04924 | 0.73402011 |
46 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.71771217 |
47 | Huntingtons disease_Homo sapiens_hsa05016 | 0.70696801 |
48 | Tuberculosis_Homo sapiens_hsa05152 | 0.70030679 |
49 | Leishmaniasis_Homo sapiens_hsa05140 | 0.66460819 |
50 | Insulin resistance_Homo sapiens_hsa04931 | 0.65495898 |
51 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.63406330 |
52 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.62752615 |
53 | Malaria_Homo sapiens_hsa05144 | 0.60428015 |
54 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.58640740 |
55 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.58042877 |
56 | Allograft rejection_Homo sapiens_hsa05330 | 0.56255103 |
57 | Tight junction_Homo sapiens_hsa04530 | 0.52511184 |
58 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.52395470 |
59 | Viral myocarditis_Homo sapiens_hsa05416 | 0.51087193 |
60 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.49849344 |
61 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.49840041 |
62 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.49733838 |
63 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.48668252 |
64 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.46680685 |
65 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.46225728 |
66 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.45758436 |
67 | Hepatitis C_Homo sapiens_hsa05160 | 0.45316835 |
68 | Peroxisome_Homo sapiens_hsa04146 | 0.44551355 |
69 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.44378431 |
70 | Pertussis_Homo sapiens_hsa05133 | 0.44348920 |
71 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.43987538 |
72 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.42124681 |
73 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.42063840 |
74 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.42057555 |
75 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.40003792 |
76 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.39560595 |
77 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.39436272 |
78 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.37314301 |
79 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.37138766 |
80 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.36755765 |
81 | Prion diseases_Homo sapiens_hsa05020 | 0.36611325 |
82 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.36336567 |
83 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.33829402 |
84 | Purine metabolism_Homo sapiens_hsa00230 | 0.32487365 |
85 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.31111412 |
86 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.30687018 |
87 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.30557588 |
88 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.29098108 |
89 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.28880147 |
90 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.28720408 |
91 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.27873387 |
92 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.27124306 |
93 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.25610412 |
94 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.25445201 |
95 | Adherens junction_Homo sapiens_hsa04520 | 0.22681766 |
96 | Insulin secretion_Homo sapiens_hsa04911 | 0.22515123 |
97 | Platelet activation_Homo sapiens_hsa04611 | 0.20495943 |
98 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.20087501 |
99 | Apoptosis_Homo sapiens_hsa04210 | 0.18889879 |
100 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.18836629 |