ASL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.66311075
2L-phenylalanine catabolic process (GO:0006559)7.66311075
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.42937277
4L-phenylalanine metabolic process (GO:0006558)7.42937277
5aromatic amino acid family catabolic process (GO:0009074)6.96538841
6tryptophan catabolic process (GO:0006569)6.35123048
7indole-containing compound catabolic process (GO:0042436)6.35123048
8indolalkylamine catabolic process (GO:0046218)6.35123048
9epoxygenase P450 pathway (GO:0019373)6.13541608
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.09820402
11kynurenine metabolic process (GO:0070189)6.01388455
12tryptophan metabolic process (GO:0006568)5.99316188
13bile acid biosynthetic process (GO:0006699)5.81219158
14glyoxylate metabolic process (GO:0046487)5.79037945
15* urea cycle (GO:0000050)5.59483218
16* urea metabolic process (GO:0019627)5.59483218
17high-density lipoprotein particle remodeling (GO:0034375)5.43834803
18serine family amino acid catabolic process (GO:0009071)5.38774562
19sulfur amino acid catabolic process (GO:0000098)5.34189352
20negative regulation of fibrinolysis (GO:0051918)5.33982457
21cysteine metabolic process (GO:0006534)5.24576349
22omega-hydroxylase P450 pathway (GO:0097267)5.19633989
23regulation of fibrinolysis (GO:0051917)5.17485740
24protein carboxylation (GO:0018214)5.16225917
25peptidyl-glutamic acid carboxylation (GO:0017187)5.16225917
26aromatic amino acid family metabolic process (GO:0009072)5.12556478
27alpha-linolenic acid metabolic process (GO:0036109)5.12417414
28* nitrogen cycle metabolic process (GO:0071941)5.11620864
29complement activation, alternative pathway (GO:0006957)5.07213259
30regulation of protein activation cascade (GO:2000257)5.01473302
31tyrosine metabolic process (GO:0006570)4.95809744
32regulation of cholesterol esterification (GO:0010872)4.90368679
33homocysteine metabolic process (GO:0050667)4.89646998
34bile acid metabolic process (GO:0008206)4.89156871
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.88383092
36regulation of plasminogen activation (GO:0010755)4.84520113
37regulation of triglyceride catabolic process (GO:0010896)4.74872095
38reverse cholesterol transport (GO:0043691)4.71186646
39* alpha-amino acid catabolic process (GO:1901606)4.69666552
40regulation of complement activation (GO:0030449)4.66775323
41plasma lipoprotein particle remodeling (GO:0034369)4.65788787
42protein-lipid complex remodeling (GO:0034368)4.65788787
43macromolecular complex remodeling (GO:0034367)4.65788787
44amino-acid betaine metabolic process (GO:0006577)4.65302261
45drug metabolic process (GO:0017144)4.61154792
46glycine metabolic process (GO:0006544)4.59544146
47lysine metabolic process (GO:0006553)4.56712843
48lysine catabolic process (GO:0006554)4.56712843
49phospholipid efflux (GO:0033700)4.54597583
50indolalkylamine metabolic process (GO:0006586)4.54043807
51cellular biogenic amine catabolic process (GO:0042402)4.49109196
52amine catabolic process (GO:0009310)4.49109196
53aldehyde catabolic process (GO:0046185)4.48192660
54triglyceride homeostasis (GO:0070328)4.43731185
55acylglycerol homeostasis (GO:0055090)4.43731185
56ethanol metabolic process (GO:0006067)4.43586269
57negative regulation of cholesterol transport (GO:0032375)4.42616312
58negative regulation of sterol transport (GO:0032372)4.42616312
59coenzyme catabolic process (GO:0009109)4.36456929
60imidazole-containing compound metabolic process (GO:0052803)4.35999889
61serine family amino acid metabolic process (GO:0009069)4.33964057
62* cellular amino acid catabolic process (GO:0009063)4.31819869
63drug catabolic process (GO:0042737)4.27995843
64plasma lipoprotein particle clearance (GO:0034381)4.22270132
65bile acid and bile salt transport (GO:0015721)4.18997367
66benzene-containing compound metabolic process (GO:0042537)4.17418300
67cellular glucuronidation (GO:0052695)4.16083742
68cellular ketone body metabolic process (GO:0046950)4.14949734
69cellular modified amino acid catabolic process (GO:0042219)4.12118570
70glutamate metabolic process (GO:0006536)4.09419179
71serine family amino acid biosynthetic process (GO:0009070)4.09243290
72negative regulation of hemostasis (GO:1900047)4.08526290
73negative regulation of blood coagulation (GO:0030195)4.08526290
74cholesterol efflux (GO:0033344)4.06490565
75* arginine metabolic process (GO:0006525)4.05536293
76phenylpropanoid metabolic process (GO:0009698)3.97917887
77exogenous drug catabolic process (GO:0042738)3.96517679
78fibrinolysis (GO:0042730)3.93448512
79NAD biosynthetic process (GO:0009435)3.91082750
80cofactor catabolic process (GO:0051187)3.89825639
81plasma lipoprotein particle assembly (GO:0034377)3.89703190
82low-density lipoprotein particle remodeling (GO:0034374)3.89379467
83glucuronate metabolic process (GO:0019585)3.87079946
84uronic acid metabolic process (GO:0006063)3.87079946
85blood coagulation, intrinsic pathway (GO:0007597)3.86460594
86positive regulation of lipoprotein lipase activity (GO:0051006)3.85903671
87positive regulation of triglyceride lipase activity (GO:0061365)3.85903671
88ethanol oxidation (GO:0006069)3.84670615
89negative regulation of coagulation (GO:0050819)3.83224832
90dicarboxylic acid biosynthetic process (GO:0043650)3.79206826
91* organic acid catabolic process (GO:0016054)3.78639219
92* carboxylic acid catabolic process (GO:0046395)3.78639219
93nicotinamide nucleotide biosynthetic process (GO:0019359)3.75275994
94pyridine nucleotide biosynthetic process (GO:0019363)3.75275994
95proline metabolic process (GO:0006560)3.71227173
96positive regulation of fatty acid biosynthetic process (GO:0045723)3.69431053
97negative regulation of lipase activity (GO:0060192)3.67247289
98negative regulation of wound healing (GO:0061045)3.63368238
99cholesterol homeostasis (GO:0042632)3.62216569
100ketone body metabolic process (GO:1902224)3.59766077
101acute-phase response (GO:0006953)3.59588151
102protein activation cascade (GO:0072376)3.59072534
103positive regulation of lipid catabolic process (GO:0050996)3.58856537
104very-low-density lipoprotein particle assembly (GO:0034379)3.58855565
105sterol homeostasis (GO:0055092)3.56043118
106flavonoid metabolic process (GO:0009812)3.55656275
107complement activation, classical pathway (GO:0006958)3.55461208
108regulation of bile acid biosynthetic process (GO:0070857)3.55096720
109urate metabolic process (GO:0046415)3.55012695
110plasma lipoprotein particle organization (GO:0071827)3.53881720
111acetyl-CoA metabolic process (GO:0006084)3.53665737
112complement activation (GO:0006956)3.52466941
113intestinal cholesterol absorption (GO:0030299)3.50883987
114regulation of humoral immune response (GO:0002920)3.50076926
115oxidative demethylation (GO:0070989)3.42314762
116positive regulation of blood coagulation (GO:0030194)3.41923702
117positive regulation of hemostasis (GO:1900048)3.41923702
118protein-lipid complex assembly (GO:0065005)3.38804454
119regulation of apoptotic cell clearance (GO:2000425)3.35378468
120fat-soluble vitamin biosynthetic process (GO:0042362)3.27181174
121primary alcohol catabolic process (GO:0034310)3.26176555
122protein-lipid complex subunit organization (GO:0071825)3.25074899
123positive regulation of coagulation (GO:0050820)3.23883614
124alkaloid metabolic process (GO:0009820)3.21361678
125negative regulation of protein activation cascade (GO:2000258)3.20985098
126NADH metabolic process (GO:0006734)3.19411375
127negative regulation of fatty acid biosynthetic process (GO:0045717)3.18494227
128hormone catabolic process (GO:0042447)3.16004048
129lipoprotein metabolic process (GO:0042157)3.15372664
130intestinal absorption (GO:0050892)3.14809922
131positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.10996359
132acute inflammatory response (GO:0002526)3.06852541
133polyketide metabolic process (GO:0030638)3.03985903
134doxorubicin metabolic process (GO:0044598)3.03985903
135daunorubicin metabolic process (GO:0044597)3.03985903
136regulation of cholesterol metabolic process (GO:0090181)3.03391487
137oxaloacetate metabolic process (GO:0006107)3.02278133
138cytolysis (GO:0019835)2.99764043

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.28781265
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.18172363
3PPARA_22158963_ChIP-Seq_LIVER_Mouse7.10050025
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.24771791
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.40283718
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.27972270
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.84412144
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.23024047
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.73840971
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.54981476
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.38185458
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.18612833
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07452984
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8882758
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90544298
16ELK3_25401928_ChIP-Seq_HUVEC_Human1.82475772
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.80208976
18RACK7_27058665_Chip-Seq_MCF-7_Human1.75995279
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.56543868
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.53830600
21VDR_21846776_ChIP-Seq_THP-1_Human1.49875188
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49734501
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45858205
24SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43548918
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40522983
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40249264
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39712621
28HTT_18923047_ChIP-ChIP_STHdh_Human1.33254357
29* HNF4A_19822575_ChIP-Seq_HepG2_Human1.32287396
30GATA1_22025678_ChIP-Seq_K562_Human1.31784939
31ELF1_20517297_ChIP-Seq_JURKAT_Human1.31637700
32FOXA2_19822575_ChIP-Seq_HepG2_Human1.31260932
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27735017
34SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27290763
35BCOR_27268052_Chip-Seq_Bcells_Human1.25931327
36KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21296102
37RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21279911
38CLOCK_20551151_ChIP-Seq_293T_Human1.21198804
39P68_20966046_ChIP-Seq_HELA_Human1.21025093
40GATA6_25053715_ChIP-Seq_YYC3_Human1.20969380
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20362270
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19903980
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11923802
44ATF3_27146783_Chip-Seq_COLON_Human1.09716222
45SMC4_20622854_ChIP-Seq_HELA_Human1.07435971
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.07058353
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06744211
48PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04504732
49E2F1_20622854_ChIP-Seq_HELA_Human1.04334902
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04110874
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01717332
52* SOX2_20726797_ChIP-Seq_SW620_Human1.01575136
53UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01408187
54P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00503962
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00301726
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98234121
57SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97442517
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96290196
59RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95926276
60SA1_27219007_Chip-Seq_Bcells_Human0.95019364
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94614821
62TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94525768
63PHF8_20622854_ChIP-Seq_HELA_Human0.94400133
64ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93272663
65VDR_24763502_ChIP-Seq_THP-1_Human0.93111471
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92870464
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92616994
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92311528
69NCOR1_26117541_ChIP-Seq_K562_Human0.91849018
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91546076
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90780285
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90603595
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89581160
74KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89224281
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88732475
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88615517
77TCF7_22412390_ChIP-Seq_EML_Mouse0.88393648
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87312980
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87171405
80PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87010549
81Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83333839
82SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80999526
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78527936
84SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76321130
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76044319
86RARA_24833708_ChIP-Seq_LIVER_Mouse0.74340599
87SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72980427
88RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72640729
89BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72626756
90GATA4_25053715_ChIP-Seq_YYC3_Human0.71394970
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69707396
92RARB_24833708_ChIP-Seq_LIVER_Mouse0.66751503
93* AR_20517297_ChIP-Seq_VCAP_Human0.66529488
94STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66469053
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.65709116
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64069598
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.63448692
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.63092056
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.60890954
100CDX2_20551321_ChIP-Seq_CACO-2_Human0.58794080
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.58633360
102EGR1_19032775_ChIP-ChIP_M12_Human0.58452498
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.57629544
104* CEBPB_22108803_ChIP-Seq_LS180_Human0.56814005
105LXR_22292898_ChIP-Seq_THP-1_Human0.55491203
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54965789
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.54441933
108STAT1_17558387_ChIP-Seq_HELA_Human0.53996107
109ELF1_17652178_ChIP-ChIP_JURKAT_Human0.53279974
110SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.50683946
111GATA1_19941827_ChIP-Seq_MEL_Mouse0.50596323
112IRF1_19129219_ChIP-ChIP_H3396_Human0.50470708
113STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.50401631
114SRF_21415370_ChIP-Seq_HL-1_Mouse0.50184262
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.49918363
116ESET_19884257_ChIP-Seq_ESCs_Mouse0.49863213
117SALL4_18804426_ChIP-ChIP_XEN_Mouse0.49394991
118NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.48986006
119* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.48384664
120P53_21459846_ChIP-Seq_SAOS-2_Human0.47714149
121PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47284741
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.46735936
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.46735936
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.46692578
125ERG_20517297_ChIP-Seq_VCAP_Human0.46488179
126TAF2_19829295_ChIP-Seq_ESCs_Human0.46317249
127MYC_19915707_ChIP-ChIP_AK7_Human0.45806758
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45752880
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45644073
130TET1_21451524_ChIP-Seq_MESCs_Mouse0.45042969
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.44972417
132IRF8_27001747_Chip-Seq_BMDM_Mouse0.44578561
133FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.43982953
134CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.43654478
135ZNF263_19887448_ChIP-Seq_K562_Human0.43179727
136BRD4_27068464_Chip-Seq_AML-cells_Mouse0.41233539
137CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.40876685
138ESR1_21235772_ChIP-Seq_MCF-7_Human0.40511144
139IRF8_21731497_ChIP-ChIP_J774_Mouse0.40294844
140PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.39583907
141FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.38919681
142SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.38416708
143FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.38288388
144CBP_21632823_ChIP-Seq_H3396_Human0.38232398
145GATA2_22383799_ChIP-Seq_G1ME_Mouse0.38154634
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.37343852
147LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.36951463
148GATA1_22383799_ChIP-Seq_G1ME_Mouse0.36742396
149BCL6_27268052_Chip-Seq_Bcells_Human0.36697902

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.12354131
2MP0005360_urolithiasis7.41069836
3MP0005085_abnormal_gallbladder_physiolo6.25471021
4MP0005365_abnormal_bile_salt5.99002906
5MP0008875_abnormal_xenobiotic_pharmacok4.95461179
6MP0003806_abnormal_nucleotide_metabolis4.16866387
7MP0003252_abnormal_bile_duct3.73825344
8MP0010329_abnormal_lipoprotein_level3.40864900
9MP0009840_abnormal_foam_cell3.23188480
10MP0005083_abnormal_biliary_tract2.94604135
11MP0003195_calcinosis2.90122171
12* MP0005332_abnormal_amino_acid2.89452038
13MP0003191_abnormal_cellular_cholesterol2.44861519
14MP0001666_abnormal_nutrient_absorption2.44331391
15MP0004019_abnormal_vitamin_homeostasis2.27239390
16MP0002138_abnormal_hepatobiliary_system2.25973332
17MP0000609_abnormal_liver_physiology2.10257633
18MP0003868_abnormal_feces_composition2.04012925
19MP0002118_abnormal_lipid_homeostasis1.97075062
20MP0001764_abnormal_homeostasis1.93215851
21MP0005319_abnormal_enzyme/_coenzyme1.89598550
22MP0009697_abnormal_copulation1.64851572
23MP0005584_abnormal_enzyme/coenzyme_acti1.57576787
24MP0003186_abnormal_redox_activity1.54006392
25MP0003011_delayed_dark_adaptation1.51892959
26MP0005451_abnormal_body_composition1.51007089
27MP0010234_abnormal_vibrissa_follicle1.46621802
28MP0009643_abnormal_urine_homeostasis1.42295558
29MP0003656_abnormal_erythrocyte_physiolo1.39539662
30MP0009764_decreased_sensitivity_to1.27336490
31MP0000598_abnormal_liver_morphology1.21455799
32MP0008260_abnormal_autophagy1.18639564
33MP0005023_abnormal_wound_healing1.15128446
34MP0004264_abnormal_extraembryonic_tissu1.12727505
35MP0010155_abnormal_intestine_physiology1.11783800
36MP0005636_abnormal_mineral_homeostasis1.09661069
37MP0003303_peritoneal_inflammation1.09254528
38MP0008438_abnormal_cutaneous_collagen1.08738608
39MP0008469_abnormal_protein_level1.08649923
40MP0005647_abnormal_sex_gland1.08611484
41MP0002876_abnormal_thyroid_physiology1.07805735
42MP0005408_hypopigmentation1.07134871
43MP0009763_increased_sensitivity_to1.04227853
44MP0003566_abnormal_cell_adhesion1.01996862
45MP0000858_altered_metastatic_potential1.01190503
46MP0005084_abnormal_gallbladder_morpholo0.99475074
47MP0002254_reproductive_system_inflammat0.92236280
48* MP0009642_abnormal_blood_homeostasis0.91846378
49MP0003172_abnormal_lysosome_physiology0.91023674
50MP0005670_abnormal_white_adipose0.88605295
51MP0004272_abnormal_basement_membrane0.87137058
52MP0006036_abnormal_mitochondrial_physio0.87098725
53MP0001849_ear_inflammation0.86643396
54MP0005376_homeostasis/metabolism_phenot0.84018582
55MP0000604_amyloidosis0.83962182
56MP0001756_abnormal_urination0.82340669
57MP0009765_abnormal_xenobiotic_induced0.81974141
58MP0003724_increased_susceptibility_to0.81880722
59MP0002822_catalepsy0.78082617
60MP0001533_abnormal_skeleton_physiology0.76686635
61MP0003436_decreased_susceptibility_to0.75378107
62MP0000678_abnormal_parathyroid_gland0.75144090
63MP0005220_abnormal_exocrine_pancreas0.74975894
64MP0005464_abnormal_platelet_physiology0.74785045
65MP0000003_abnormal_adipose_tissue0.74690041
66MP0002078_abnormal_glucose_homeostasis0.74276813
67MP0003183_abnormal_peptide_metabolism0.73279017
68MP0000013_abnormal_adipose_tissue0.72756394
69MP0004947_skin_inflammation0.72663826
70MP0010368_abnormal_lymphatic_system0.70971537
71MP0003453_abnormal_keratinocyte_physiol0.70420496
72MP0003329_amyloid_beta_deposits0.70306907
73MP0009333_abnormal_splenocyte_physiolog0.68483972
74MP0001663_abnormal_digestive_system0.67351958
75MP0005334_abnormal_fat_pad0.67089138
76MP0003705_abnormal_hypodermis_morpholog0.67014212
77MP0005257_abnormal_intraocular_pressure0.66166077
78MP0002796_impaired_skin_barrier0.65380907
79MP0003879_abnormal_hair_cell0.64758386
80MP0005266_abnormal_metabolism0.63602556
81MP0000467_abnormal_esophagus_morphology0.63160228
82MP0002136_abnormal_kidney_physiology0.62751058
83MP0003718_maternal_effect0.62665205
84MP0004381_abnormal_hair_follicle0.62581386
85MP0005535_abnormal_body_temperature0.62309360
86MP0001873_stomach_inflammation0.60729718
87MP0001661_extended_life_span0.60580536
88MP0005666_abnormal_adipose_tissue0.59561436
89MP0002971_abnormal_brown_adipose0.59356933
90MP0005165_increased_susceptibility_to0.59300393
91MP0005375_adipose_tissue_phenotype0.59082976
92MP0005501_abnormal_skin_physiology0.58181054
93MP0000639_abnormal_adrenal_gland0.57571197
94MP0001915_intracranial_hemorrhage0.56443513
95MP0002060_abnormal_skin_morphology0.55099219
96MP0005381_digestive/alimentary_phenotyp0.55017746
97MP0000477_abnormal_intestine_morphology0.54163742
98MP0005395_other_phenotype0.53696594
99MP0002148_abnormal_hypersensitivity_rea0.53200066
100MP0003638_abnormal_response/metabolism_0.53030693
101MP0009053_abnormal_anal_canal0.52741546
102MP0003866_abnormal_defecation0.52542710
103MP0009379_abnormal_foot_pigmentation0.52066930
104MP0009785_altered_susceptibility_to0.51221909
105MP0001853_heart_inflammation0.50800415
106MP0006035_abnormal_mitochondrial_morpho0.50294566
107MP0001845_abnormal_inflammatory_respons0.49968548
108MP0008873_increased_physiological_sensi0.49691828
109MP0002928_abnormal_bile_duct0.49659217
110MP0005448_abnormal_energy_balance0.48031557
111MP0004782_abnormal_surfactant_physiolog0.47674844
112MP0004130_abnormal_muscle_cell0.47085882
113MP0005058_abnormal_lysosome_morphology0.47081560
114MP0006082_CNS_inflammation0.44767028
115MP0002132_abnormal_respiratory_system0.44052676
116MP0008874_decreased_physiological_sensi0.41967358
117MP0003075_altered_response_to0.40871708
118MP0003953_abnormal_hormone_level0.40546485
119MP0005075_abnormal_melanosome_morpholog0.40465918
120MP0008872_abnormal_physiological_respon0.39660264
121MP0005025_abnormal_response_to0.39603146
122MP0000249_abnormal_blood_vessel0.38973052
123MP0001835_abnormal_antigen_presentation0.37472673
124MP0002419_abnormal_innate_immunity0.36518080
125MP0004883_abnormal_blood_vessel0.36458433
126MP0005166_decreased_susceptibility_to0.36332548
127MP0003690_abnormal_glial_cell0.36216322
128MP0000538_abnormal_urinary_bladder0.34830030
129MP0000230_abnormal_systemic_arterial0.34561827
130MP0002168_other_aberrant_phenotype0.33098770
131MP0002135_abnormal_kidney_morphology0.32920090
132MP0009115_abnormal_fat_cell0.31504848
133MP0002970_abnormal_white_adipose0.29503186
134MP0001881_abnormal_mammary_gland0.29307139
135MP0000685_abnormal_immune_system0.28967769
136MP0000579_abnormal_nail_morphology0.27173641
137MP0005164_abnormal_response_to0.26685913

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.64673361
2Deep venous thrombosis (HP:0002625)6.74981385
3Intrahepatic cholestasis (HP:0001406)6.74245247
4* Abnormality of monocarboxylic acid metabolism (HP:0010996)6.58564503
5Prolonged partial thromboplastin time (HP:0003645)6.48390554
6Hypobetalipoproteinemia (HP:0003563)6.03253914
7Xanthomatosis (HP:0000991)6.00034843
8Hyperlipoproteinemia (HP:0010980)5.23899519
9Complement deficiency (HP:0004431)4.98959317
10Joint hemorrhage (HP:0005261)4.97961317
11Hyperglycinemia (HP:0002154)4.52382522
12Abnormality of methionine metabolism (HP:0010901)4.51776721
13Hypolipoproteinemia (HP:0010981)4.43908551
14* Hyperammonemia (HP:0001987)4.39225876
15Abnormality of aspartate family amino acid metabolism (HP:0010899)4.38235422
16Abnormality of sulfur amino acid metabolism (HP:0004339)4.33917483
17Epidermoid cyst (HP:0200040)4.25826760
18Abnormality of the common coagulation pathway (HP:0010990)4.25567278
19Hyperglycinuria (HP:0003108)4.19350778
20Ketosis (HP:0001946)4.12791169
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.05667475
22* Abnormality of glutamine family amino acid metabolism (HP:0010902)4.03187612
23Abnormality of serine family amino acid metabolism (HP:0010894)3.95523720
24Abnormality of glycine metabolism (HP:0010895)3.95523720
25Fat malabsorption (HP:0002630)3.88224779
26Hypoalphalipoproteinemia (HP:0003233)3.86416822
27* Abnormality of pyrimidine metabolism (HP:0004353)3.76728683
28Abnormality of complement system (HP:0005339)3.75646713
29Hypoglycemic coma (HP:0001325)3.65814508
30Conjugated hyperbilirubinemia (HP:0002908)3.60389550
31Abnormality of the intrinsic pathway (HP:0010989)3.59307782
32Abnormality of fatty-acid metabolism (HP:0004359)3.45606702
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.40424142
34Hypercholesterolemia (HP:0003124)3.37537386
35Hyperbilirubinemia (HP:0002904)3.33299124
36* Abnormality of nucleobase metabolism (HP:0010932)3.08142222
37Delayed CNS myelination (HP:0002188)3.04381266
38Steatorrhea (HP:0002570)2.99954955
39Hepatocellular carcinoma (HP:0001402)2.92186408
40* Abnormality of serum amino acid levels (HP:0003112)2.91869855
41Spontaneous abortion (HP:0005268)2.84655875
42Systemic lupus erythematosus (HP:0002725)2.83450119
43Metabolic acidosis (HP:0001942)2.82898727
44Ketoacidosis (HP:0001993)2.82359848
45Purpura (HP:0000979)2.81164290
46Myocardial infarction (HP:0001658)2.79267688
47Abnormality of purine metabolism (HP:0004352)2.76966558
48* Lethargy (HP:0001254)2.74201693
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.72840901
50Dicarboxylic aciduria (HP:0003215)2.72840901
51Recurrent gram-negative bacterial infections (HP:0005420)2.66564870
52Vascular calcification (HP:0004934)2.61099824
53Glomerulonephritis (HP:0000099)2.60434702
54Gout (HP:0001997)2.60117309
55Skin nodule (HP:0200036)2.54887404
56Abnormality of the Achilles tendon (HP:0005109)2.53511109
57Increased serum ferritin (HP:0003281)2.51063157
58Hypochromic microcytic anemia (HP:0004840)2.47068235
59Generalized aminoaciduria (HP:0002909)2.40722041
60Urinary glycosaminoglycan excretion (HP:0003541)2.37889423
61Mucopolysacchariduria (HP:0008155)2.37889423
62Spastic diplegia (HP:0001264)2.37035654
63Menorrhagia (HP:0000132)2.35145979
64* Cerebral edema (HP:0002181)2.33836346
65Late onset (HP:0003584)2.33185272
66Hypoglycemic seizures (HP:0002173)2.31630000
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.30797678
68Abnormality of polysaccharide metabolism (HP:0011012)2.30797678
69Abnormality of glycosaminoglycan metabolism (HP:0004371)2.30797678
70Pancreatitis (HP:0001733)2.30520092
71Amyloidosis (HP:0011034)2.30451700
72* Irritability (HP:0000737)2.30128515
73Gingival bleeding (HP:0000225)2.29794300
74Malnutrition (HP:0004395)2.27597185
75Mitral stenosis (HP:0001718)2.26309901
76Cardiovascular calcification (HP:0011915)2.26206927
77Elevated alkaline phosphatase (HP:0003155)2.25584374
78Enlarged kidneys (HP:0000105)2.22594979
79Acanthocytosis (HP:0001927)2.21299071
80Abnormality of alkaline phosphatase activity (HP:0004379)2.21265297
81Abnormal gallbladder morphology (HP:0012437)2.20458614
82Thrombophlebitis (HP:0004418)2.19801189
83Dysostosis multiplex (HP:0000943)2.18337990
84Opisthotonus (HP:0002179)2.17986922
85Vertebral compression fractures (HP:0002953)2.17958970
86Cholelithiasis (HP:0001081)2.15313008
87Abnormal gallbladder physiology (HP:0012438)2.14767179
88Cholecystitis (HP:0001082)2.14767179
89* Vomiting (HP:0002013)2.14028868
90Brushfield spots (HP:0001088)2.13195429
91J-shaped sella turcica (HP:0002680)2.10991623
92Esophageal varix (HP:0002040)2.08142257
93Vacuolated lymphocytes (HP:0001922)2.06270212
94* Neonatal onset (HP:0003623)2.05794565
95Proximal tubulopathy (HP:0000114)2.01587511
96Abnormality of urine glucose concentration (HP:0011016)2.00739380
97Glycosuria (HP:0003076)2.00739380
98Sensorimotor neuropathy (HP:0007141)1.99874337
99Flat acetabular roof (HP:0003180)1.99554145
100Renal cortical cysts (HP:0000803)1.98364730
101Elevated hepatic transaminases (HP:0002910)1.97802386
102Abnormality of proline metabolism (HP:0010907)1.97799184
103Hydroxyprolinuria (HP:0003080)1.97799184
104Abnormality of iron homeostasis (HP:0011031)1.96318446
105Cerebral palsy (HP:0100021)1.95704425
106Rickets (HP:0002748)1.93077218
107Abnormality of transition element cation homeostasis (HP:0011030)1.92616802
108Abnormality of carpal bone ossification (HP:0006257)1.89017966
109Reticulocytosis (HP:0001923)1.87971552
110Hypophosphatemic rickets (HP:0004912)1.87441426
111Impaired platelet aggregation (HP:0003540)1.86985255
112Abnormal platelet function (HP:0011869)1.86985255
113Nephritis (HP:0000123)1.85957249
114Hemorrhage of the eye (HP:0011885)1.85601243
115* Alkalosis (HP:0001948)1.85591017
116Achilles tendon contracture (HP:0001771)1.85485472
117Hypertriglyceridemia (HP:0002155)1.85282549
118Abdominal distention (HP:0003270)1.85173977
119Abnormality of the gallbladder (HP:0005264)1.85007620
120Nausea (HP:0002018)1.84399563
121Poikilocytosis (HP:0004447)1.82463408
122Epistaxis (HP:0000421)1.82025729
123Abnormal enzyme/coenzyme activity (HP:0012379)1.81963875
124Cervical subluxation (HP:0003308)1.79475688
125Reduced antithrombin III activity (HP:0001976)1.79361609
126Abnormality of liposaccharide metabolism (HP:0010968)1.79017208
127Abnormality of glycosphingolipid metabolism (HP:0004343)1.79017208
128Abnormality of glycolipid metabolism (HP:0010969)1.79017208
129Ileus (HP:0002595)1.77836666
130Increased serum pyruvate (HP:0003542)1.77752887
131Prolonged neonatal jaundice (HP:0006579)1.76511422
132Hypophosphatemia (HP:0002148)1.73156152
133Abnormality of glycolysis (HP:0004366)1.73094548
134Abnormal tarsal ossification (HP:0008369)1.71888497

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.22042947
2FGFR44.11086720
3EPHA24.05084392
4ERN14.04827442
5SIK13.53418678
6TAOK32.98331603
7FLT32.68894973
8INSRR2.68764428
9ERBB42.48826035
10RIPK12.32433657
11TESK22.21693515
12TESK12.15949427
13LMTK22.11743661
14IRAK32.11634237
15MAPK112.04874718
16SMG11.84999648
17NME21.84995764
18MST1R1.81975642
19TYK21.81937977
20MAP3K141.77999678
21PRPF4B1.75985182
22MAP3K121.69686522
23NEK91.68975257
24MAP2K41.67571832
25PIK3CG1.67252971
26TBK11.63583740
27PAK41.59858429
28PKN21.52120272
29ABL21.50925573
30PDK21.46069386
31MAP2K31.40138430
32KDR1.40085329
33IKBKE1.23824324
34GRK61.19916902
35MAPKAPK31.19687793
36MAP3K111.18855733
37JAK21.18290058
38STK161.12205117
39PINK11.10975906
40PDPK11.05181225
41MAPK41.04228952
42ARAF1.01676745
43TIE11.01421781
44MAP3K11.00233224
45ICK0.99539949
46SCYL20.99047580
47EPHA30.98927413
48STK38L0.98568664
49PRKAA20.97887388
50MAP2K60.94453470
51PTK60.92379454
52DAPK20.91686388
53JAK10.90808398
54ERBB20.90799775
55IRAK40.90401650
56ZAP700.89455343
57BLK0.88325408
58PDGFRA0.87886576
59TAOK20.87839814
60TLK10.86562254
61CDC42BPA0.85759583
62DDR20.85030585
63FRK0.83936775
64PRKD20.83548719
65MAP3K70.83065725
66LIMK10.82202486
67PIK3CA0.82156200
68IKBKB0.82041698
69CSK0.81287726
70NLK0.80949107
71IRAK10.80652204
72MAP3K30.80525250
73EIF2AK30.79421877
74MAPK120.78584615
75DYRK1B0.77554979
76KIT0.76374502
77TGFBR20.74036037
78ILK0.70879010
79TAOK10.70747791
80PBK0.70252411
81TRIB30.69804846
82MAPK150.67236624
83MAP4K10.67128814
84EPHB20.67088431
85PRKCZ0.67035752
86KSR20.66771941
87IRAK20.66653148
88EEF2K0.63212797
89BTK0.62338585
90CSF1R0.61972274
91JAK30.61058265
92PRKACG0.60770551
93LATS10.58550647
94BMX0.57981209
95TEC0.57853422
96MAP3K60.57671694
97SGK20.57315844
98GSK3A0.57122333
99MAP3K100.56541096
100CSNK1G10.55788892
101CAMK2G0.55440003
102TXK0.54456691
103CAMK40.53914856
104MAP3K80.53614073
105DAPK30.53545582
106PRKCI0.52668740
107PDK10.52585196
108MET0.52443390
109CDK60.51335314
110SGK30.50951836
111EPHB10.50785401
112RPS6KB20.50501225
113GRK10.49028705
114FER0.48919351
115LRRK20.47485086
116CHUK0.46714278
117MAP3K20.46130676
118IGF1R0.44005706
119PTK20.42257750
120LYN0.40900432
121DAPK10.39040570
122PRKAA10.38993210
123PIM10.37698055
124MAPKAPK20.37474023
125FGFR30.35362326
126CDK40.34354416
127MST40.34301867
128NME10.34151989
129EIF2AK20.34143720
130EIF2AK10.33858856
131SRC0.33599483
132RET0.32922823
133MAP3K50.31943831
134NTRK10.30771375
135MAP3K130.30416470
136MAP2K10.30318543
137PIM20.30204829
138MATK0.30063639
139MTOR0.29927233
140PRKCQ0.29681293
141AKT20.28681489
142MAP2K20.28488030
143AKT30.28429289
144SGK2230.28210279
145SGK4940.28210279
146MYLK0.28008838
147SYK0.27823624
148PRKG20.27646347
149FGR0.24316752

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.45172123
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44288078
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35893321
4Nitrogen metabolism_Homo sapiens_hsa009103.17914449
5* Arginine biosynthesis_Homo sapiens_hsa002203.00316180
6Tryptophan metabolism_Homo sapiens_hsa003802.72190421
7Complement and coagulation cascades_Homo sapiens_hsa046102.70151615
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.68418758
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62533569
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58701500
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.42266727
12Fatty acid degradation_Homo sapiens_hsa000712.39546490
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35197709
14Peroxisome_Homo sapiens_hsa041462.16235585
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15786086
16Butanoate metabolism_Homo sapiens_hsa006502.01530908
17Histidine metabolism_Homo sapiens_hsa003401.99288423
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.96930830
19Chemical carcinogenesis_Homo sapiens_hsa052041.94411235
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92981255
21Propanoate metabolism_Homo sapiens_hsa006401.82963544
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.82936551
23Staphylococcus aureus infection_Homo sapiens_hsa051501.78767115
24PPAR signaling pathway_Homo sapiens_hsa033201.76688943
25beta-Alanine metabolism_Homo sapiens_hsa004101.72748485
26Phenylalanine metabolism_Homo sapiens_hsa003601.71675324
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69635620
28Retinol metabolism_Homo sapiens_hsa008301.68343227
29Caffeine metabolism_Homo sapiens_hsa002321.64969315
30Fatty acid metabolism_Homo sapiens_hsa012121.63962677
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63538507
32Selenocompound metabolism_Homo sapiens_hsa004501.62959174
33Tyrosine metabolism_Homo sapiens_hsa003501.54617342
34* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52382927
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51142218
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48479472
37Folate biosynthesis_Homo sapiens_hsa007901.43199472
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.40607559
39Sulfur metabolism_Homo sapiens_hsa009201.37340053
40Bile secretion_Homo sapiens_hsa049761.36389334
41Pyruvate metabolism_Homo sapiens_hsa006201.30784473
42Starch and sucrose metabolism_Homo sapiens_hsa005001.29229519
43Fatty acid elongation_Homo sapiens_hsa000621.25656470
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.19567904
45* Biosynthesis of amino acids_Homo sapiens_hsa012301.18207631
46Steroid biosynthesis_Homo sapiens_hsa001001.17171829
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16713521
48ABC transporters_Homo sapiens_hsa020101.13635095
49Sulfur relay system_Homo sapiens_hsa041221.11960678
50Carbon metabolism_Homo sapiens_hsa012001.11932835
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11323371
52Arginine and proline metabolism_Homo sapiens_hsa003301.07976110
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07804904
54Fat digestion and absorption_Homo sapiens_hsa049751.07709273
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.06916979
56One carbon pool by folate_Homo sapiens_hsa006701.00547363
57Vitamin digestion and absorption_Homo sapiens_hsa049770.96294479
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76021173
59Glutathione metabolism_Homo sapiens_hsa004800.74644899
60Lysine degradation_Homo sapiens_hsa003100.72486918
61Vitamin B6 metabolism_Homo sapiens_hsa007500.72472415
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69767122
63Pentose phosphate pathway_Homo sapiens_hsa000300.67516100
64Glycerolipid metabolism_Homo sapiens_hsa005610.62360164
65* Metabolic pathways_Homo sapiens_hsa011000.52845204
66Mineral absorption_Homo sapiens_hsa049780.51914269
67Lysosome_Homo sapiens_hsa041420.42904956
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39826989
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38676279
70Fructose and mannose metabolism_Homo sapiens_hsa000510.35583080
71Galactose metabolism_Homo sapiens_hsa000520.35136935
72Sphingolipid metabolism_Homo sapiens_hsa006000.31915572
73N-Glycan biosynthesis_Homo sapiens_hsa005100.31272008
74Prion diseases_Homo sapiens_hsa050200.27001782
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25670196
76Fatty acid biosynthesis_Homo sapiens_hsa000610.24961915
77Linoleic acid metabolism_Homo sapiens_hsa005910.21741285
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14721969
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14652235
80Vibrio cholerae infection_Homo sapiens_hsa051100.14272173
81Insulin resistance_Homo sapiens_hsa049310.13992821
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.13954527
83Amoebiasis_Homo sapiens_hsa051460.13107029
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11168257
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.07969376
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.05514638
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05228975
88Arachidonic acid metabolism_Homo sapiens_hsa005900.00298435
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.2068510
90Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1991746
91Legionellosis_Homo sapiens_hsa05134-0.1984266
92Insulin signaling pathway_Homo sapiens_hsa04910-0.1847923
93Protein export_Homo sapiens_hsa03060-0.1818643
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1758244
95Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1709700
96Renin-angiotensin system_Homo sapiens_hsa04614-0.1674544
97Pertussis_Homo sapiens_hsa05133-0.1479481
98Hepatitis C_Homo sapiens_hsa05160-0.1367559
99Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1256244
100Other glycan degradation_Homo sapiens_hsa00511-0.1234358
101African trypanosomiasis_Homo sapiens_hsa05143-0.1171625
102Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1158310
103Pyrimidine metabolism_Homo sapiens_hsa00240-0.1080403
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0741023
105AMPK signaling pathway_Homo sapiens_hsa04152-0.0683651
106Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0581925
107Shigellosis_Homo sapiens_hsa05131-0.0470239
108Bacterial invasion of epithelial cells_Homo sapiens_hsa05100-0.0433708
109Regulation of autophagy_Homo sapiens_hsa04140-0.0288285
110Protein digestion and absorption_Homo sapiens_hsa04974-0.0248237
111Bladder cancer_Homo sapiens_hsa05219-0.0244059
112Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0088394
113Glucagon signaling pathway_Homo sapiens_hsa04922-0.0083697
114Leishmaniasis_Homo sapiens_hsa05140-0.0023102

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