ASLP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interleukin-1-mediated signaling pathway (GO:0070498)6.32360289
2positive regulation of prostaglandin secretion (GO:0032308)4.75006688
3regulation of interleukin-12 biosynthetic process (GO:0045075)4.57724565
4amyloid precursor protein catabolic process (GO:0042987)4.56201874
5low-density lipoprotein particle remodeling (GO:0034374)4.46958342
6high-density lipoprotein particle remodeling (GO:0034375)4.39560935
7regulation of cholesterol esterification (GO:0010872)4.34751251
8regulation of B cell receptor signaling pathway (GO:0050855)4.18920205
9phospholipid homeostasis (GO:0055091)4.09883493
10positive regulation of T cell cytokine production (GO:0002726)4.05370025
11T-helper 1 type immune response (GO:0042088)3.98825529
12positive regulation of heat generation (GO:0031652)3.90903517
13regulation of prostaglandin secretion (GO:0032306)3.85749170
14protein-cofactor linkage (GO:0018065)3.81749296
15regulation of mitotic spindle checkpoint (GO:1903504)3.80971490
16regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.80971490
17Arp2/3 complex-mediated actin nucleation (GO:0034314)3.76274303
18cellular response to interleukin-15 (GO:0071350)3.73108316
19positive regulation of bone remodeling (GO:0046852)3.72671323
20positive regulation of bone resorption (GO:0045780)3.72671323
21positive regulation of gamma-delta T cell activation (GO:0046645)3.72355306
22regulation of fever generation (GO:0031620)3.71395444
23toxin transport (GO:1901998)3.70202721
24reverse cholesterol transport (GO:0043691)3.69839110
25negative regulation of cell killing (GO:0031342)3.66314810
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.66314810
27phospholipid efflux (GO:0033700)3.66289032
28activated T cell proliferation (GO:0050798)3.61617663
29regulation of immunoglobulin secretion (GO:0051023)3.61522061
30response to interleukin-15 (GO:0070672)3.61119096
31peptidyl-threonine dephosphorylation (GO:0035970)3.55112409
32neutrophil activation (GO:0042119)3.51987269
33positive regulation of icosanoid secretion (GO:0032305)3.42585213
34cellular ketone body metabolic process (GO:0046950)3.42470404
35regulation of T cell cytokine production (GO:0002724)3.40566163
36negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.37110682
37negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.36965622
38negative regulation of T-helper cell differentiation (GO:0045623)3.36965622
39positive regulation of osteoclast differentiation (GO:0045672)3.34973506
40positive regulation of granulocyte differentiation (GO:0030854)3.33371167
41negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.32300176
42regulation of interleukin-6 biosynthetic process (GO:0045408)3.31994937
43dendritic cell chemotaxis (GO:0002407)3.22746354
44seminiferous tubule development (GO:0072520)3.21530002
45antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.21402135
46positive regulation of fatty acid transport (GO:2000193)3.13105411
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.12394242
48neutrophil activation involved in immune response (GO:0002283)3.11010111
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.09818197
50granulocyte activation (GO:0036230)3.06254521
51leukocyte migration involved in inflammatory response (GO:0002523)3.05532751
52regulation of heat generation (GO:0031650)3.04919538
53antigen processing and presentation of endogenous antigen (GO:0019883)3.03690347
54actin nucleation (GO:0045010)3.03514057
55mast cell activation (GO:0045576)3.03472092
56mucosal-associated lymphoid tissue development (GO:0048537)3.01912992
57Peyers patch development (GO:0048541)3.01912992
58response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.94817467
59response to host (GO:0075136)2.94817467
60response to host defenses (GO:0052200)2.94817467
61monocyte chemotaxis (GO:0002548)2.94466886
62regulation of gamma-delta T cell activation (GO:0046643)2.93588788
63cellular extravasation (GO:0045123)2.90843370
64ketone body metabolic process (GO:1902224)2.89958742
65regulation of icosanoid secretion (GO:0032303)2.89570854
66positive regulation of T cell differentiation in thymus (GO:0033089)2.89518287
67sulfation (GO:0051923)2.86874566
68tumor necrosis factor-mediated signaling pathway (GO:0033209)2.86210731
69response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.85599146
70response to host immune response (GO:0052572)2.85599146
71modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.83386581
72positive regulation by organism of defense response of other organism involved in symbiotic interact2.83386581
73modulation by symbiont of host immune response (GO:0052553)2.83386581
74positive regulation by symbiont of host defense response (GO:0052509)2.83386581
75modulation by symbiont of host defense response (GO:0052031)2.83386581
76modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.83386581
77bone resorption (GO:0045453)2.82365076
78cell wall macromolecule catabolic process (GO:0016998)2.77068199
79germinal center formation (GO:0002467)2.75970348
80protein-lipid complex remodeling (GO:0034368)2.75038059
81macromolecular complex remodeling (GO:0034367)2.75038059
82plasma lipoprotein particle remodeling (GO:0034369)2.75038059
83negative regulation of alpha-beta T cell differentiation (GO:0046639)2.74986302
84regulation of skeletal muscle cell differentiation (GO:2001014)2.74312063
85positive regulation of cholesterol efflux (GO:0010875)2.73848098
86dendritic cell migration (GO:0036336)2.72844222
87negative regulation of meiotic cell cycle (GO:0051447)2.72684293
88regulation of cholesterol biosynthetic process (GO:0045540)2.70586839
89positive regulation of transcription regulatory region DNA binding (GO:2000679)2.70358555
90viral protein processing (GO:0019082)2.69312032
91activation of NF-kappaB-inducing kinase activity (GO:0007250)2.69024381
92neutrophil mediated immunity (GO:0002446)2.65960697
93negative thymic T cell selection (GO:0045060)2.65685996
94regulation of gamma-delta T cell differentiation (GO:0045586)2.65296696
95regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63906244
96response to lipoprotein particle (GO:0055094)2.60240982
97fucose catabolic process (GO:0019317)2.59980852
98L-fucose metabolic process (GO:0042354)2.59980852
99L-fucose catabolic process (GO:0042355)2.59980852
100respiratory burst (GO:0045730)2.59049663

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.10223575
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.79727290
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.60397406
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.21491724
5CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.85670666
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.70731326
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54831257
8ZNF274_21170338_ChIP-Seq_K562_Hela2.46378691
9RUNX_20019798_ChIP-Seq_JUKART_Human2.44147255
10SPI1_23547873_ChIP-Seq_NB4_Human2.39013043
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36162850
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.35101245
13VDR_23849224_ChIP-Seq_CD4+_Human2.23448141
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.22432364
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.22334955
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.21233965
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.14808360
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.13596194
19MYB_26560356_Chip-Seq_TH2_Human2.11345845
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.08115455
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.05698741
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.04180697
23FOXP3_21729870_ChIP-Seq_TREG_Human2.00430355
24GATA3_26560356_Chip-Seq_TH2_Human1.99291094
25UTX_26944678_Chip-Seq_JUKART_Human1.96567802
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96270274
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94116405
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.87213505
29MYB_26560356_Chip-Seq_TH1_Human1.84701612
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82553310
31SPI1_23127762_ChIP-Seq_K562_Human1.82495704
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.77642072
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76723988
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73274590
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.70298332
36MAF_26560356_Chip-Seq_TH1_Human1.64372659
37VDR_24763502_ChIP-Seq_THP-1_Human1.60491883
38VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.57092237
39VDR_21846776_ChIP-Seq_THP-1_Human1.56310134
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55752163
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.49017562
42SCL_19346495_ChIP-Seq_HPC-7_Human1.48519048
43GATA3_27048872_Chip-Seq_THYMUS_Human1.47847220
44KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.47771441
45KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.47771441
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.47771441
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.47547834
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46694194
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45958918
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.45500614
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43050651
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.40679530
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38310351
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38068174
55FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36005912
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35741788
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34537211
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28464724
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27532514
60GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25886886
61BCL6_27268052_Chip-Seq_Bcells_Human1.24165776
62GABP_19822575_ChIP-Seq_HepG2_Human1.23778202
63CIITA_25753668_ChIP-Seq_RAJI_Human1.22338196
64KDM5A_27292631_Chip-Seq_BREAST_Human1.22259801
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22121353
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.18732552
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16654498
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.15682091
69MYC_19829295_ChIP-Seq_ESCs_Human1.15431946
70BCOR_27268052_Chip-Seq_Bcells_Human1.15357095
71VDR_22108803_ChIP-Seq_LS180_Human1.15214986
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14816654
73MAF_26560356_Chip-Seq_TH2_Human1.12430180
74RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11489072
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11093889
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10432030
77P300_27268052_Chip-Seq_Bcells_Human1.06453182
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05714441
79EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05574340
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05273539
81MYC_18940864_ChIP-ChIP_HL60_Human1.04391753
82E2F1_20622854_ChIP-Seq_HELA_Human1.04240188
83VDR_24787735_ChIP-Seq_THP-1_Human1.04137207
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03847445
85SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.03827448
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03561221
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.02922625
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01637372
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01368889
90PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01030547
91CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00841866
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00525230
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98362521
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98240375
95SMRT_27268052_Chip-Seq_Bcells_Human0.97211377
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97084949
97PHF8_20622854_ChIP-Seq_HELA_Human0.96695188
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.96527819
99FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94092343
100FOXA1_25329375_ChIP-Seq_VCAP_Human0.94092343

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.34601762
2MP0003436_decreased_susceptibility_to4.20960576
3MP0000685_abnormal_immune_system3.66495047
4MP0003191_abnormal_cellular_cholesterol3.24269508
5MP0009840_abnormal_foam_cell3.15491436
6MP0002405_respiratory_system_inflammati2.73794475
7MP0005671_abnormal_response_to2.63911016
8MP0001800_abnormal_humoral_immune2.55831976
9MP0002148_abnormal_hypersensitivity_rea2.55507739
10MP0002419_abnormal_innate_immunity2.53405142
11MP0002723_abnormal_immune_serum2.38379016
12MP0001790_abnormal_immune_system2.35790348
13MP0005387_immune_system_phenotype2.35790348
14MP0005000_abnormal_immune_tolerance2.20269971
15MP0008875_abnormal_xenobiotic_pharmacok2.17538313
16MP0001835_abnormal_antigen_presentation2.16903458
17MP0002452_abnormal_antigen_presenting2.07138087
18MP0002420_abnormal_adaptive_immunity2.04974784
19MP0001819_abnormal_immune_cell2.04968992
20MP0005025_abnormal_response_to2.00736987
21MP0005058_abnormal_lysosome_morphology1.99880708
22MP0003195_calcinosis1.98202684
23MP0001533_abnormal_skeleton_physiology1.88683733
24MP0009764_decreased_sensitivity_to1.77238515
25MP0002398_abnormal_bone_marrow1.74206795
26MP0003763_abnormal_thymus_physiology1.69240024
27MP0009785_altered_susceptibility_to1.65079408
28MP0000689_abnormal_spleen_morphology1.64442542
29MP0000716_abnormal_immune_system1.61114881
30MP0002396_abnormal_hematopoietic_system1.59995195
31MP0009278_abnormal_bone_marrow1.58753031
32MP0005187_abnormal_penis_morphology1.57732628
33MP0006292_abnormal_olfactory_placode1.56678258
34MP0003828_pulmonary_edema1.56261500
35MP0001764_abnormal_homeostasis1.49231100
36MP0009765_abnormal_xenobiotic_induced1.49081671
37MP0004947_skin_inflammation1.48659761
38MP0004142_abnormal_muscle_tone1.48483896
39MP0002722_abnormal_immune_system1.46147133
40MP0001986_abnormal_taste_sensitivity1.45663202
41MP0004147_increased_porphyrin_level1.41717258
42MP0000703_abnormal_thymus_morphology1.41367612
43MP0008469_abnormal_protein_level1.40570099
44MP0010155_abnormal_intestine_physiology1.31094357
45MP0004782_abnormal_surfactant_physiolog1.30953136
46MP0005377_hearing/vestibular/ear_phenot1.28263040
47MP0003878_abnormal_ear_physiology1.28263040
48MP0002429_abnormal_blood_cell1.27239503
49MP0001845_abnormal_inflammatory_respons1.26086866
50MP0002132_abnormal_respiratory_system1.25263456
51MP0005379_endocrine/exocrine_gland_phen1.25191860
52MP0003303_peritoneal_inflammation1.25125505
53MP0002277_abnormal_respiratory_mucosa1.22153269
54MP0005464_abnormal_platelet_physiology1.17786423
55MP0005535_abnormal_body_temperature1.13993146
56MP0004133_heterotaxia1.12892790
57MP0002138_abnormal_hepatobiliary_system1.11411404
58MP0002095_abnormal_skin_pigmentation1.10383394
59MP0003172_abnormal_lysosome_physiology1.10129110
60MP0002876_abnormal_thyroid_physiology1.07034110
61MP0005448_abnormal_energy_balance0.98457507
62MP0002163_abnormal_gland_morphology0.96895561
63MP0002998_abnormal_bone_remodeling0.96748279
64MP0003315_abnormal_perineum_morphology0.94232215
65MP0005075_abnormal_melanosome_morpholog0.93164950
66MP0001873_stomach_inflammation0.92985874
67MP0003806_abnormal_nucleotide_metabolis0.88972065
68MP0009763_increased_sensitivity_to0.87952365
69MP0010329_abnormal_lipoprotein_level0.84886907
70MP0008058_abnormal_DNA_repair0.81140042
71MP0000609_abnormal_liver_physiology0.79912401
72MP0002653_abnormal_ependyma_morphology0.79363121
73MP0006082_CNS_inflammation0.78910590
74MP0009333_abnormal_splenocyte_physiolog0.78645159
75MP0008007_abnormal_cellular_replicative0.78540808
76MP0005365_abnormal_bile_salt0.75931785
77MP0003252_abnormal_bile_duct0.75320092
78MP0002127_abnormal_cardiovascular_syste0.73735701
79MP0001919_abnormal_reproductive_system0.73356238
80MP0006035_abnormal_mitochondrial_morpho0.73354503
81MP0002693_abnormal_pancreas_physiology0.72194627
82MP0003866_abnormal_defecation0.67274175
83MP0003183_abnormal_peptide_metabolism0.66791588
84MP0005636_abnormal_mineral_homeostasis0.66649695
85MP0000358_abnormal_cell_content/0.64892613
86MP0005319_abnormal_enzyme/_coenzyme0.64353449
87MP0008872_abnormal_physiological_respon0.63800070
88MP0001501_abnormal_sleep_pattern0.63796136
89MP0008995_early_reproductive_senescence0.63279999
90MP0001968_abnormal_touch/_nociception0.63248098
91MP0000639_abnormal_adrenal_gland0.62951186
92MP0009642_abnormal_blood_homeostasis0.62740599
93MP0000598_abnormal_liver_morphology0.61332162
94MP0005646_abnormal_pituitary_gland0.59868424
95MP0005410_abnormal_fertilization0.59857163
96MP0005376_homeostasis/metabolism_phenot0.56485334
97MP0002736_abnormal_nociception_after0.56444173
98MP0001529_abnormal_vocalization0.56018264
99MP0005310_abnormal_salivary_gland0.55648801
100MP0003786_premature_aging0.55341578

Predicted human phenotypes

RankGene SetZ-score
1Premature loss of primary teeth (HP:0006323)4.81497472
2Increased density of long bones (HP:0006392)4.51312431
3Stomatitis (HP:0010280)3.82593922
4Panhypogammaglobulinemia (HP:0003139)3.56051766
5Abnormal delayed hypersensitivity skin test (HP:0002963)3.52109077
6Recurrent cutaneous fungal infections (HP:0011370)3.47454327
7Chronic mucocutaneous candidiasis (HP:0002728)3.47454327
8Agammaglobulinemia (HP:0004432)3.45635899
9Rib fusion (HP:0000902)3.37149006
10Recurrent fungal infections (HP:0002841)3.35704371
11Mediastinal lymphadenopathy (HP:0100721)3.17300705
12Respiratory difficulties (HP:0002880)3.12141785
13Persistence of primary teeth (HP:0006335)3.08878212
14Cerebellar dysplasia (HP:0007033)3.07436134
15Recurrent abscess formation (HP:0002722)2.97670579
16Myositis (HP:0100614)2.96440194
17Severe combined immunodeficiency (HP:0004430)2.92985365
18Hypochromic microcytic anemia (HP:0004840)2.91777578
19Hepatosplenomegaly (HP:0001433)2.89852382
20Cholecystitis (HP:0001082)2.84211314
21Abnormal gallbladder physiology (HP:0012438)2.84211314
22Type II lissencephaly (HP:0007260)2.82421624
23Pustule (HP:0200039)2.82332702
24Optic neuritis (HP:0100653)2.81410845
25Retrobulbar optic neuritis (HP:0100654)2.81410845
26Urinary glycosaminoglycan excretion (HP:0003541)2.81236735
27Mucopolysacchariduria (HP:0008155)2.81236735
28Dysostosis multiplex (HP:0000943)2.81200996
29Chronic hepatic failure (HP:0100626)2.75691163
30Abnormality of polysaccharide metabolism (HP:0011012)2.74684893
31Abnormality of glycosaminoglycan metabolism (HP:0004371)2.74684893
32Abnormality of mucopolysaccharide metabolism (HP:0011020)2.74684893
33Loss of speech (HP:0002371)2.74287164
34Asymmetric septal hypertrophy (HP:0001670)2.67081945
353-Methylglutaconic aciduria (HP:0003535)2.67031729
36Obstructive lung disease (HP:0006536)2.66740706
37Chronic obstructive pulmonary disease (HP:0006510)2.66740706
38Abnormality of macrophages (HP:0004311)2.66530465
39Encephalitis (HP:0002383)2.62176684
40Hypochromic anemia (HP:0001931)2.60596178
41Abnormality of primary teeth (HP:0006481)2.60352882
42Orchitis (HP:0100796)2.53246717
43Meningitis (HP:0001287)2.51125042
44Retinal dysplasia (HP:0007973)2.49278406
45Increased hepatocellular lipid droplets (HP:0006565)2.46353446
46Recurrent skin infections (HP:0001581)2.45717885
47Recurrent bacterial skin infections (HP:0005406)2.45381553
48Abnormality of T cells (HP:0002843)2.44060482
49Hypoplasia of the thymus (HP:0000778)2.43209286
50Recurrent gram-negative bacterial infections (HP:0005420)2.32928950
51Abnormality of eosinophils (HP:0001879)2.32578724
52Abnormality of T cell number (HP:0011839)2.31488502
53IgG deficiency (HP:0004315)2.29924838
54True hermaphroditism (HP:0010459)2.29295198
55Eczematoid dermatitis (HP:0000976)2.28062379
56Combined immunodeficiency (HP:0005387)2.26019257
57Abnormality of T cell physiology (HP:0011840)2.25257590
58Pulmonary infiltrates (HP:0002113)2.24013259
59Abnormal biliary tract physiology (HP:0012439)2.22466076
60Bile duct proliferation (HP:0001408)2.22466076
61T lymphocytopenia (HP:0005403)2.21511862
62Large for gestational age (HP:0001520)2.17978804
63Lipid accumulation in hepatocytes (HP:0006561)2.13130852
64Granulocytopenia (HP:0001913)2.12154969
65Prolonged bleeding time (HP:0003010)2.07154044
66Leukocytosis (HP:0001974)2.06784703
67Vacuolated lymphocytes (HP:0001922)2.04955310
68Stomach cancer (HP:0012126)2.04089340
69Hemivertebrae (HP:0002937)1.98078919
70Recurrent viral infections (HP:0004429)1.96988223
71Pancreatic cysts (HP:0001737)1.91535975
72Supernumerary spleens (HP:0009799)1.89296120
73Pancreatic fibrosis (HP:0100732)1.89026959
74Eosinophilia (HP:0001880)1.87791024
75Increased neuronal autofluorescent lipopigment (HP:0002074)1.86794140
76Inflammation of the large intestine (HP:0002037)1.85137445
77Colitis (HP:0002583)1.84944669
78Pallor (HP:0000980)1.84851221
79Attenuation of retinal blood vessels (HP:0007843)1.84516088
80Autoimmune hemolytic anemia (HP:0001890)1.83389159
81Abnormality of B cell number (HP:0010975)1.82729717
82Vasculitis (HP:0002633)1.82422900
83IgM deficiency (HP:0002850)1.81062138
84Hyperinsulinemic hypoglycemia (HP:0000825)1.80731540
85Joint stiffness (HP:0001387)1.78273795
86Parakeratosis (HP:0001036)1.78110716
87Autoimmune thrombocytopenia (HP:0001973)1.78028798
88Abnormality of dental color (HP:0011073)1.77758506
89Keratoconjunctivitis sicca (HP:0001097)1.77418264
90Abnormality of DNA repair (HP:0003254)1.75479684
91Thyroid-stimulating hormone excess (HP:0002925)1.74739913
92Nephronophthisis (HP:0000090)1.74611306
93Hemoptysis (HP:0002105)1.74322255
94Increased IgE level (HP:0003212)1.73662946
95Anorexia (HP:0002039)1.73575978
96Supernumerary bones of the axial skeleton (HP:0009144)1.72105404
97Polyneuropathy (HP:0001271)1.71166416
98Severe visual impairment (HP:0001141)1.70752679
99Alveolar cell carcinoma (HP:0006519)1.70569216
100Neutropenia (HP:0001875)1.70252186

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.30166542
2MAP4K13.29751194
3TLK13.08037497
4RIPK42.76095875
5IRAK42.55690985
6TNK22.55433320
7CDC42BPA2.46663379
8MAP3K112.18202017
9TAOK32.18038369
10CDK82.12726111
11MAP2K22.00372672
12BCKDK1.95499865
13MAP3K141.90108157
14MAP4K21.88673138
15MAP3K71.81031548
16TBK11.80082889
17TXK1.74297722
18MAP3K131.73670820
19TYK21.71024110
20GRK61.70941571
21MST41.70849598
22PBK1.62842209
23WNK31.62780014
24FES1.60191595
25IKBKE1.57902400
26EPHA31.49837143
27MATK1.39866622
28BLK1.37140206
29TEC1.36813118
30KIT1.35869181
31ITK1.35328073
32BTK1.33885365
33SYK1.31886421
34ZAP701.30463188
35IKBKB1.23873255
36NEK91.22235296
37MAP2K31.20598689
38LYN1.11637741
39SIK21.09242580
40EIF2AK11.08959795
41HCK1.08557292
42MAP3K121.07023800
43TAOK11.00138961
44LCK0.97295271
45DYRK20.97285970
46IRAK20.96001783
47IRAK10.92176614
48MELK0.90147401
49CSF1R0.87973741
50ACVR1B0.85433385
51PDK20.85339042
52ERN10.83867670
53PAK30.82309736
54CSK0.81197276
55FGR0.78297083
56BMPR20.78187938
57CDK40.77896530
58CDK190.75138974
59MAP3K50.74766468
60JAK30.74109163
61MAP2K60.69519841
62MAP2K10.66066068
63GRK10.61388280
64PRKD20.59620875
65MAP2K40.57656761
66INSRR0.56803880
67STK110.56721580
68DYRK30.54200366
69ALK0.48211226
70GRK70.48137733
71EPHB10.48068681
72PDK10.47927248
73MAP3K30.47755780
74VRK20.46901865
75JAK20.46508201
76DYRK1A0.45709152
77WNK40.44552877
78MAP3K10.44028600
79CHUK0.43619500
80BMX0.42616182
81PIM10.40385554
82MAPK30.40159699
83PASK0.39386913
84BMPR1B0.38166404
85RPS6KA10.37684640
86PLK40.33025154
87PINK10.32853160
88PIK3CG0.32479022
89VRK10.32413323
90FGFR40.32260077
91MARK30.30643156
92MARK20.30612728
93CDK30.29292612
94JAK10.28429978
95CDC70.28159706
96MKNK10.27707918
97MAPK150.26515904
98SRPK10.26355041
99PDPK10.25237334
100SIK30.25064365

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004007.30463733
2Nitrogen metabolism_Homo sapiens_hsa009103.14259037
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.03613885
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.80099881
5Primary immunodeficiency_Homo sapiens_hsa053402.53463914
6Osteoclast differentiation_Homo sapiens_hsa043802.29640945
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25425879
8Caffeine metabolism_Homo sapiens_hsa002322.01852788
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.97629184
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.89395190
11Other glycan degradation_Homo sapiens_hsa005111.78493758
12Hematopoietic cell lineage_Homo sapiens_hsa046401.75523036
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67213707
14RNA polymerase_Homo sapiens_hsa030201.66730108
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.62146285
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61360366
17ABC transporters_Homo sapiens_hsa020101.59838634
18Leishmaniasis_Homo sapiens_hsa051401.59476153
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58610917
20Staphylococcus aureus infection_Homo sapiens_hsa051501.54335090
21Fanconi anemia pathway_Homo sapiens_hsa034601.52419424
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51114524
23Tryptophan metabolism_Homo sapiens_hsa003801.48288615
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48027408
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.30983410
26Phenylalanine metabolism_Homo sapiens_hsa003601.29941729
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.29789080
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29715189
29Homologous recombination_Homo sapiens_hsa034401.25781328
30B cell receptor signaling pathway_Homo sapiens_hsa046621.17858836
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13004650
32Mismatch repair_Homo sapiens_hsa034301.10824593
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09576133
34Butanoate metabolism_Homo sapiens_hsa006501.03555917
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02630741
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99868093
37Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95828930
38Tuberculosis_Homo sapiens_hsa051520.94337889
39Cyanoamino acid metabolism_Homo sapiens_hsa004600.91308659
40Epstein-Barr virus infection_Homo sapiens_hsa051690.86275777
41Oxidative phosphorylation_Homo sapiens_hsa001900.83456243
42Complement and coagulation cascades_Homo sapiens_hsa046100.83275258
43Nucleotide excision repair_Homo sapiens_hsa034200.83094406
44Measles_Homo sapiens_hsa051620.81276879
45T cell receptor signaling pathway_Homo sapiens_hsa046600.80810144
46Rheumatoid arthritis_Homo sapiens_hsa053230.80193781
47Chemokine signaling pathway_Homo sapiens_hsa040620.80062585
48Type I diabetes mellitus_Homo sapiens_hsa049400.79966522
49African trypanosomiasis_Homo sapiens_hsa051430.79947584
50Ribosome_Homo sapiens_hsa030100.79445264
51One carbon pool by folate_Homo sapiens_hsa006700.76599255
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75297297
53Allograft rejection_Homo sapiens_hsa053300.74620032
54TNF signaling pathway_Homo sapiens_hsa046680.74422697
55Arginine biosynthesis_Homo sapiens_hsa002200.71932453
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71868861
57Herpes simplex infection_Homo sapiens_hsa051680.70469774
58Peroxisome_Homo sapiens_hsa041460.68882641
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68648447
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67592054
61Autoimmune thyroid disease_Homo sapiens_hsa053200.67424629
62Acute myeloid leukemia_Homo sapiens_hsa052210.67149194
63Graft-versus-host disease_Homo sapiens_hsa053320.66673212
64Parkinsons disease_Homo sapiens_hsa050120.65831111
65Lysosome_Homo sapiens_hsa041420.64523582
66Pentose phosphate pathway_Homo sapiens_hsa000300.64291629
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.59809884
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58470125
69RNA degradation_Homo sapiens_hsa030180.57324900
70Malaria_Homo sapiens_hsa051440.55947354
71Protein export_Homo sapiens_hsa030600.54301286
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54004332
73Arachidonic acid metabolism_Homo sapiens_hsa005900.52621516
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.52438358
75Linoleic acid metabolism_Homo sapiens_hsa005910.50703963
76Collecting duct acid secretion_Homo sapiens_hsa049660.50540367
77Vitamin digestion and absorption_Homo sapiens_hsa049770.47387143
78Prolactin signaling pathway_Homo sapiens_hsa049170.47104158
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.45719860
80Legionellosis_Homo sapiens_hsa051340.44525989
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.43864636
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43840177
83Phototransduction_Homo sapiens_hsa047440.42965336
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42104488
85Pertussis_Homo sapiens_hsa051330.41596195
86Purine metabolism_Homo sapiens_hsa002300.39627920
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39125522
88Antigen processing and presentation_Homo sapiens_hsa046120.38660834
89Glycerolipid metabolism_Homo sapiens_hsa005610.37621385
90Chemical carcinogenesis_Homo sapiens_hsa052040.36993093
91Base excision repair_Homo sapiens_hsa034100.35997139
92Toxoplasmosis_Homo sapiens_hsa051450.34646846
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34009035
94Hepatitis C_Homo sapiens_hsa051600.32152164
95Asthma_Homo sapiens_hsa053100.31911119
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30879920
97Glutathione metabolism_Homo sapiens_hsa004800.29846412
98Galactose metabolism_Homo sapiens_hsa000520.29819228
99Fructose and mannose metabolism_Homo sapiens_hsa000510.29434678
100Circadian rhythm_Homo sapiens_hsa047100.28772794

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