ASMTL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.54162627
2viral transcription (GO:0019083)4.68945529
3modulation by virus of host process (GO:0019054)4.64356103
4L-serine metabolic process (GO:0006563)4.49276141
5modulation by symbiont of host cellular process (GO:0044068)4.34809516
6ribosomal small subunit assembly (GO:0000028)4.31590431
7translational termination (GO:0006415)4.28263655
8translational elongation (GO:0006414)4.01403413
9nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.89389945
10Arp2/3 complex-mediated actin nucleation (GO:0034314)3.77953463
11viral life cycle (GO:0019058)3.77109761
12pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.70264334
13pentose-phosphate shunt (GO:0006098)3.68121467
14NIK/NF-kappaB signaling (GO:0038061)3.67976601
15peptidyl-arginine omega-N-methylation (GO:0035247)3.66621303
16pyrimidine nucleotide catabolic process (GO:0006244)3.62515694
17ncRNA 3-end processing (GO:0043628)3.59563682
18modulation by symbiont of host immune response (GO:0052553)3.58564512
19positive regulation by symbiont of host defense response (GO:0052509)3.58564512
20modulation by symbiont of host defense response (GO:0052031)3.58564512
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.58564512
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.58564512
23positive regulation by organism of defense response of other organism involved in symbiotic interact3.58564512
24activation of MAPKKK activity (GO:0000185)3.45155760
25histone arginine methylation (GO:0034969)3.44010827
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.39913476
27NADPH regeneration (GO:0006740)3.30064684
28adenine nucleotide transport (GO:0051503)3.28663138
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.26865638
30positive regulation of release of cytochrome c from mitochondria (GO:0090200)3.25493531
31cellular protein complex disassembly (GO:0043624)3.25486667
32deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.25364152
33protein targeting to ER (GO:0045047)3.22453378
34phosphatidylglycerol biosynthetic process (GO:0006655)3.19210856
353-UTR-mediated mRNA stabilization (GO:0070935)3.18622906
36protein complex disassembly (GO:0043241)3.18111304
37immunoglobulin mediated immune response (GO:0016064)3.14915859
38cotranslational protein targeting to membrane (GO:0006613)3.11837104
39pentose metabolic process (GO:0019321)3.10253126
40positive regulation of protein homooligomerization (GO:0032464)3.06461320
41protein localization to endoplasmic reticulum (GO:0070972)3.05751738
42maturation of SSU-rRNA (GO:0030490)3.05331593
43serine family amino acid biosynthetic process (GO:0009070)3.05210349
44peptidyl-arginine N-methylation (GO:0035246)3.04417323
45peptidyl-arginine methylation (GO:0018216)3.04417323
46establishment of protein localization to endoplasmic reticulum (GO:0072599)3.04097552
47negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02598810
48positive thymic T cell selection (GO:0045059)2.98139509
49purine ribonucleotide transport (GO:0015868)2.96593225
50negative regulation of interleukin-12 production (GO:0032695)2.93970659
51purine deoxyribonucleotide catabolic process (GO:0009155)2.92541448
52negative regulation of phagocytosis (GO:0050765)2.88734690
53cellular response to virus (GO:0098586)2.87364221
54post-embryonic morphogenesis (GO:0009886)2.87181552
55positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.86595749
56deoxyribonucleotide catabolic process (GO:0009264)2.84819264
57negative regulation of B cell apoptotic process (GO:0002903)2.84415100
58thymic T cell selection (GO:0045061)2.83996431
59macromolecular complex disassembly (GO:0032984)2.82626559
60positive regulation of gamma-delta T cell activation (GO:0046645)2.81016215
61translational initiation (GO:0006413)2.80090062
62response to protozoan (GO:0001562)2.79445301
63positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.76217127
64pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.75248865
65nucleosome disassembly (GO:0006337)2.74091103
66protein-DNA complex disassembly (GO:0032986)2.74091103
67regulation of interleukin-2 biosynthetic process (GO:0045076)2.73271640
68negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.73016736
69glucose catabolic process (GO:0006007)2.69775119
70B cell mediated immunity (GO:0019724)2.67038669
71positive regulation of protein oligomerization (GO:0032461)2.65865035
72deoxyribose phosphate catabolic process (GO:0046386)2.65629496
73response to muramyl dipeptide (GO:0032495)2.60931894
74negative regulation of amino acid transport (GO:0051956)2.59024827
75modulation by virus of host morphology or physiology (GO:0019048)2.58264602
76regulation of podosome assembly (GO:0071801)2.57714796
77regulation of type I interferon-mediated signaling pathway (GO:0060338)2.56170227
78regulation of B cell apoptotic process (GO:0002902)2.55693618
79cellular response to interleukin-4 (GO:0071353)2.55235389
80response to peptidoglycan (GO:0032494)2.54968186
81negative regulation of granulocyte differentiation (GO:0030853)2.54592211
82cellular hyperosmotic response (GO:0071474)2.53230178
83intracellular estrogen receptor signaling pathway (GO:0030520)2.53160814
84regulation of release of cytochrome c from mitochondria (GO:0090199)2.51215643
85mitochondrial fusion (GO:0008053)2.51204472
86negative regulation of erythrocyte differentiation (GO:0045647)2.50291210
87response to interleukin-4 (GO:0070670)2.49627630
88ribonucleoprotein complex biogenesis (GO:0022613)2.49143329
89UV protection (GO:0009650)2.48665155
90histone H3-K36 demethylation (GO:0070544)2.48503948
91spliceosomal tri-snRNP complex assembly (GO:0000244)2.47215765
92type I interferon signaling pathway (GO:0060337)2.45737993
93cellular response to type I interferon (GO:0071357)2.45737993
94negative regulation of RNA splicing (GO:0033119)2.45455736
95nuclear-transcribed mRNA catabolic process (GO:0000956)2.44923302
96heterochromatin organization (GO:0070828)2.44798554
97regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.43781138
98establishment of mitochondrion localization (GO:0051654)2.43641417
99regulation of mitochondrial membrane permeability (GO:0046902)2.43345917
100regulation of protein heterodimerization activity (GO:0043497)2.42781069

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.11107099
2MYC_22102868_ChIP-Seq_BL_Human3.02270729
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.80434563
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.58763551
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.56114919
6LXR_22292898_ChIP-Seq_THP-1_Human2.31320321
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29760570
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.20296525
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19389467
10CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.02264168
11MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89008556
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83246965
13XRN2_22483619_ChIP-Seq_HELA_Human1.77899867
14SRY_22984422_ChIP-ChIP_TESTIS_Rat1.77771902
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77466979
16ELK3_25401928_ChIP-Seq_HUVEC_Human1.74537004
17KDM2B_26808549_Chip-Seq_DND41_Human1.73525788
18CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.72294600
19KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69903039
20P68_20966046_ChIP-Seq_HELA_Human1.69398792
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68514228
22UTX_26944678_Chip-Seq_JUKART_Human1.68498268
23MAF_26560356_Chip-Seq_TH2_Human1.65959844
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65717422
25THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65045624
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.64866723
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64065186
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60212581
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.59892020
30TET1_21451524_ChIP-Seq_MESCs_Mouse1.55900960
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54928681
32MAF_26560356_Chip-Seq_TH1_Human1.54354954
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53134341
34VDR_24763502_ChIP-Seq_THP-1_Human1.52664388
35CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51482262
36CIITA_25753668_ChIP-Seq_RAJI_Human1.50306072
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47980164
38BCL6_27268052_Chip-Seq_Bcells_Human1.46383840
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45930394
40SA1_27219007_Chip-Seq_ERYTHROID_Human1.45723553
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.44573347
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44394986
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44093228
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43557231
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41420627
46TCF7_22412390_ChIP-Seq_EML_Mouse1.41057896
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40875688
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39904815
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39342732
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39135574
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37077000
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.36318858
53BCOR_27268052_Chip-Seq_Bcells_Human1.32577884
54GABP_19822575_ChIP-Seq_HepG2_Human1.30284915
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.27729030
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27384379
57RACK7_27058665_Chip-Seq_MCF-7_Human1.27113091
58PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25488948
59* FOXP1_21924763_ChIP-Seq_HESCs_Human1.23425881
60E2F7_22180533_ChIP-Seq_HELA_Human1.22625494
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22614592
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21714380
63CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20416227
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19844712
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19512405
66SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19496771
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.19381909
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19115563
69SMC4_20622854_ChIP-Seq_HELA_Human1.18755208
70SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18170975
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17770265
72CTCF_26484167_Chip-Seq_Bcells_Mouse1.15159733
73CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15000600
74PHF8_20622854_ChIP-Seq_HELA_Human1.14558850
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13773338
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13561910
77SA1_27219007_Chip-Seq_Bcells_Human1.13463321
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13061731
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12684109
80STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11736894
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.11211523
82EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10985039
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10532242
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10427872
85SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10111382
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09961300
87CTCF_21964334_Chip-Seq_Bcells_Human1.09711436
88OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08533456
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07757886
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07270187
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05819901
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04773221
93RUNX1_22412390_ChIP-Seq_EML_Mouse1.04419856
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04299224
95RARA_24833708_ChIP-Seq_LIVER_Mouse1.04173713
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04038095
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03878156
98SPI1_23547873_ChIP-Seq_NB4_Human1.02918976
99YY1_22570637_ChIP-Seq_MALME-3M_Human1.02207907
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02114124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow3.90678884
2MP0002254_reproductive_system_inflammat3.89673822
3MP0003303_peritoneal_inflammation3.60321561
4MP0002138_abnormal_hepatobiliary_system3.07422394
5MP0005058_abnormal_lysosome_morphology2.80687807
6MP0003436_decreased_susceptibility_to2.53751476
7MP0001545_abnormal_hematopoietic_system2.53452064
8MP0005397_hematopoietic_system_phenotyp2.53452064
9MP0006292_abnormal_olfactory_placode2.51729903
10MP0000685_abnormal_immune_system2.34963747
11MP0001849_ear_inflammation2.19641076
12MP0005671_abnormal_response_to2.16561218
13MP0005000_abnormal_immune_tolerance2.15719073
14MP0001800_abnormal_humoral_immune2.12747990
15MP0001790_abnormal_immune_system2.11242139
16MP0005387_immune_system_phenotype2.11242139
17MP0002653_abnormal_ependyma_morphology2.02704573
18MP0005025_abnormal_response_to1.98299075
19MP0002148_abnormal_hypersensitivity_rea1.96826800
20MP0001835_abnormal_antigen_presentation1.95944389
21MP0009785_altered_susceptibility_to1.92779467
22MP0009840_abnormal_foam_cell1.89434186
23MP0002452_abnormal_antigen_presenting1.84823464
24MP0002723_abnormal_immune_serum1.83087269
25MP0002419_abnormal_innate_immunity1.78688100
26MP0002420_abnormal_adaptive_immunity1.78584755
27MP0001819_abnormal_immune_cell1.77305989
28MP0009333_abnormal_splenocyte_physiolog1.72809791
29MP0000490_abnormal_crypts_of1.71181377
30MP0005394_taste/olfaction_phenotype1.69490362
31MP0005499_abnormal_olfactory_system1.69490362
32MP0002398_abnormal_bone_marrow1.67762193
33MP0004858_abnormal_nervous_system1.66467537
34MP0005451_abnormal_body_composition1.65838367
35MP0008260_abnormal_autophagy1.62355547
36MP0004510_myositis1.62171584
37MP0000716_abnormal_immune_system1.55450100
38MP0004947_skin_inflammation1.45505982
39MP0003693_abnormal_embryo_hatching1.41698111
40MP0000689_abnormal_spleen_morphology1.40782937
41MP0002429_abnormal_blood_cell1.39840833
42MP0003787_abnormal_imprinting1.39487720
43MP0005423_abnormal_somatic_nervous1.37407186
44MP0003300_gastrointestinal_ulcer1.36032595
45MP0002722_abnormal_immune_system1.34962800
46MP0010030_abnormal_orbit_morphology1.31633129
47MP0003172_abnormal_lysosome_physiology1.26861225
48MP0002405_respiratory_system_inflammati1.26105815
49MP0002132_abnormal_respiratory_system1.26021895
50MP0005464_abnormal_platelet_physiology1.23306008
51MP0008789_abnormal_olfactory_epithelium1.21919282
52MP0003878_abnormal_ear_physiology1.21069515
53MP0005377_hearing/vestibular/ear_phenot1.21069515
54MP0003111_abnormal_nucleus_morphology1.16515877
55MP0003763_abnormal_thymus_physiology1.15304916
56MP0003123_paternal_imprinting1.14447236
57MP0003075_altered_response_to1.13715952
58MP0009379_abnormal_foot_pigmentation1.13655109
59MP0001845_abnormal_inflammatory_respons1.12177636
60MP0000703_abnormal_thymus_morphology1.11493247
61MP0000750_abnormal_muscle_regeneration1.09205865
62MP0000858_altered_metastatic_potential1.09051319
63MP0000604_amyloidosis1.08224857
64MP0003122_maternal_imprinting1.07659734
65MP0001853_heart_inflammation1.05868821
66MP0002139_abnormal_hepatobiliary_system1.04078894
67MP0009765_abnormal_xenobiotic_induced1.03394931
68MP0010155_abnormal_intestine_physiology1.02886459
69MP0003121_genomic_imprinting1.01587489
70MP0001663_abnormal_digestive_system1.01268485
71MP0003724_increased_susceptibility_to1.00815677
72MP0001348_abnormal_lacrimal_gland0.99219982
73MP0008469_abnormal_protein_level0.96582464
74MP0001533_abnormal_skeleton_physiology0.95965227
75MP0006035_abnormal_mitochondrial_morpho0.95015307
76MP0009764_decreased_sensitivity_to0.91574843
77MP0002163_abnormal_gland_morphology0.89898578
78MP0006082_CNS_inflammation0.88833390
79MP0003329_amyloid_beta_deposits0.87238547
80MP0002089_abnormal_postnatal_growth/wei0.85598856
81MP0000313_abnormal_cell_death0.84715944
82MP0003183_abnormal_peptide_metabolism0.82565809
83MP0000343_altered_response_to0.81922149
84MP0001727_abnormal_embryo_implantation0.77597894
85MP0004859_abnormal_synaptic_plasticity0.74286626
86MP0010094_abnormal_chromosome_stability0.73691878
87MP0009672_abnormal_birth_weight0.73537457
88MP0002019_abnormal_tumor_incidence0.72636501
89MP0003806_abnormal_nucleotide_metabolis0.72146873
90MP0004133_heterotaxia0.71161282
91MP0009763_increased_sensitivity_to0.68043356
92MP0005257_abnormal_intraocular_pressure0.66970824
93MP0004808_abnormal_hematopoietic_stem0.66212210
94MP0002998_abnormal_bone_remodeling0.65896254
95MP0003186_abnormal_redox_activity0.65356987
96MP0005084_abnormal_gallbladder_morpholo0.64829637
97MP0000751_myopathy0.64529284
98MP0001542_abnormal_bone_strength0.60838688
99MP0006036_abnormal_mitochondrial_physio0.60728302
100MP0001730_embryonic_growth_arrest0.59486090

Predicted human phenotypes

RankGene SetZ-score
1Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.46332481
2Panhypogammaglobulinemia (HP:0003139)3.41123884
3Agammaglobulinemia (HP:0004432)3.32599921
4Reticulocytopenia (HP:0001896)3.29652570
5Thoracic kyphosis (HP:0002942)3.23224219
6Increased IgM level (HP:0003496)3.04841094
7Hyperacusis (HP:0010780)2.99336384
8Colitis (HP:0002583)2.93500214
9Multiple enchondromatosis (HP:0005701)2.93390477
10Progressive external ophthalmoplegia (HP:0000590)2.93110566
11Gastrointestinal stroma tumor (HP:0100723)2.90093683
12Cellulitis (HP:0100658)2.85416243
13Ragged-red muscle fibers (HP:0003200)2.83436807
14Abnormality of cells of the erythroid lineage (HP:0012130)2.81387612
15Personality changes (HP:0000751)2.79022021
16Obstructive lung disease (HP:0006536)2.72202181
17Chronic obstructive pulmonary disease (HP:0006510)2.72202181
18Lymphopenia (HP:0001888)2.71502961
19Mediastinal lymphadenopathy (HP:0100721)2.71382876
20Meningitis (HP:0001287)2.70559756
21IgM deficiency (HP:0002850)2.68467573
22Upper motor neuron abnormality (HP:0002127)2.68294604
23Progressive muscle weakness (HP:0003323)2.68255043
24Overriding aorta (HP:0002623)2.63712549
25Long palpebral fissure (HP:0000637)2.52161200
26Gastrointestinal inflammation (HP:0004386)2.46934239
27Myokymia (HP:0002411)2.46779994
28Abnormal number of erythroid precursors (HP:0012131)2.45962562
29Recurrent viral infections (HP:0004429)2.44552250
30Turricephaly (HP:0000262)2.44474249
31Abnormality of the thoracic spine (HP:0100711)2.41259296
32Disinhibition (HP:0000734)2.40358873
33Abnormality of cells of the lymphoid lineage (HP:0012140)2.37951200
34Choanal stenosis (HP:0000452)2.37197865
35Abnormality of macrophages (HP:0004311)2.35208656
36Hypertensive crisis (HP:0100735)2.32380121
37Microvesicular hepatic steatosis (HP:0001414)2.27878517
38Inflammation of the large intestine (HP:0002037)2.25773872
39Cholecystitis (HP:0001082)2.25384101
40Abnormal gallbladder physiology (HP:0012438)2.25384101
41Poikiloderma (HP:0001029)2.24351099
42Polygenic inheritance (HP:0010982)2.24229542
43Abnormality of reticulocytes (HP:0004312)2.23304363
44Petechiae (HP:0000967)2.23275800
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20398550
46Insomnia (HP:0100785)2.18667060
47Centrally nucleated skeletal muscle fibers (HP:0003687)2.17456742
48Increased muscle lipid content (HP:0009058)2.14753506
49Broad distal phalanx of finger (HP:0009836)2.13780212
50Deep palmar crease (HP:0006191)2.13334074
51Pallor (HP:0000980)2.12345623
52Eczematoid dermatitis (HP:0000976)2.11627079
53Increased IgE level (HP:0003212)2.10946520
54Systemic lupus erythematosus (HP:0002725)2.10416517
55Myopathic facies (HP:0002058)2.10123460
56Elfin facies (HP:0004428)2.09813059
57Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08301289
58Recurrent fungal infections (HP:0002841)2.07941345
59Recurrent sinusitis (HP:0011108)2.06619200
60Annular pancreas (HP:0001734)2.06613657
61Segmental peripheral demyelination/remyelination (HP:0003481)2.05230534
62Prolonged neonatal jaundice (HP:0006579)2.05072333
63Recurrent abscess formation (HP:0002722)2.04770254
64Dysphonia (HP:0001618)2.02354496
65Neuronal loss in central nervous system (HP:0002529)2.02201140
66Pointed chin (HP:0000307)2.00979186
67Achilles tendon contracture (HP:0001771)1.99539591
68Abnormality of lateral ventricle (HP:0030047)1.98664295
69Thrombocytosis (HP:0001894)1.98631979
70Trigonocephaly (HP:0000243)1.95905315
71Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95379006
72Vacuolated lymphocytes (HP:0001922)1.95167425
73Increased cerebral lipofuscin (HP:0011813)1.94087985
74Hepatosplenomegaly (HP:0001433)1.94004592
75Abnormal neuron morphology (HP:0012757)1.92119403
76Abnormality of the motor neurons (HP:0002450)1.92119403
77IgG deficiency (HP:0004315)1.91777490
78Impaired proprioception (HP:0010831)1.91201441
79Emphysema (HP:0002097)1.89996650
80Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89493124
81Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89493124
82Aplasia/Hypoplasia of the thymus (HP:0010515)1.89231156
83Recurrent lower respiratory tract infections (HP:0002783)1.88204033
84Encephalitis (HP:0002383)1.87532240
85Recurrent bacterial skin infections (HP:0005406)1.84953266
86IgA deficiency (HP:0002720)1.83664011
87Increased intramyocellular lipid droplets (HP:0012240)1.83611342
88Squamous cell carcinoma (HP:0002860)1.80376853
89Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78941426
90Retinal dysplasia (HP:0007973)1.78306552
91Premature loss of primary teeth (HP:0006323)1.78282503
92Vasculitis (HP:0002633)1.77862286
93Acute hepatic failure (HP:0006554)1.77667223
94Metaphyseal cupping (HP:0003021)1.76785460
95Renal duplication (HP:0000075)1.75655689
96Basal cell carcinoma (HP:0002671)1.74902809
97Aplasia/Hypoplasia of the sacrum (HP:0008517)1.74809983
98Abnormal delayed hypersensitivity skin test (HP:0002963)1.73583994
99Reticulocytosis (HP:0001923)1.72928896
100Spastic diplegia (HP:0001264)1.72206742

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.63943714
2NME23.37832534
3SMG13.35921805
4BCKDK2.95183878
5MAP3K112.75601061
6TESK22.74150025
7VRK22.41488151
8ARAF2.24032561
9PRPF4B2.21028898
10RIPK42.16781549
11MAP3K102.16609105
12CDK192.07716361
13EEF2K1.96169903
14PIM21.79049696
15CDC71.65035749
16TAOK21.62757392
17TBK11.59983954
18STK161.54555736
19TRIB31.48405769
20ERN11.43867798
21FES1.42610682
22KDR1.31878460
23TNK21.27041800
24DYRK21.22942619
25TESK11.16506902
26SIK11.13944726
27RPS6KA41.12413632
28CDK91.11591019
29MATK1.05324715
30PASK1.04985173
31MAP3K131.04232521
32MAP3K141.02183377
33CSF1R1.02116393
34TYRO31.00946836
35DAPK30.99608863
36RPS6KC10.98691117
37RPS6KL10.98691117
38KIT0.98159221
39LRRK20.94392851
40CDK40.94365161
41RPS6KA20.93121805
42PRKD30.91712846
43FGR0.88216265
44MAP2K30.88129427
45BRAF0.87423290
46MAP3K90.87113711
47SIK20.85624689
48BLK0.82656427
49DYRK30.81460162
50TGFBR10.80238217
51BMX0.79503174
52CDK140.77460163
53IKBKE0.76916520
54RPS6KA60.76313824
55FGFR40.75558476
56CDK11A0.75335855
57IKBKB0.75279028
58SYK0.74507450
59VRK10.73602849
60CDK150.70681160
61NME10.70236619
62RPS6KB20.70210723
63CDC42BPA0.70050375
64MAP3K10.70005822
65MARK20.69686313
66AURKA0.69133945
67BTK0.67867842
68MAP3K80.67865696
69PIM10.67523190
70IRAK40.66740301
71TAOK10.66724615
72PKN20.66482525
73CDK80.65545416
74MARK30.65033998
75CSNK1G30.63404826
76TAF10.61745062
77CDK180.61547023
78TYK20.61089229
79ALK0.61084497
80DAPK10.60488640
81DDR20.58372469
82CSK0.55863005
83RPS6KA50.55579100
84IRAK30.53548370
85HIPK20.53254012
86SCYL20.53228583
87ICK0.52105186
88GRK60.51706754
89RPS6KA10.51646321
90LYN0.51185531
91DYRK1B0.48800762
92CDK70.48061891
93MOS0.45612877
94PRKCQ0.43140340
95PAK10.43003761
96LCK0.40646456
97CSNK1A1L0.40616747
98SIK30.39376901
99LIMK10.36240528
100CHEK20.34468255

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.94043428
2Ribosome_Homo sapiens_hsa030103.59052391
3Base excision repair_Homo sapiens_hsa034102.82257418
4Primary immunodeficiency_Homo sapiens_hsa053402.80462399
5DNA replication_Homo sapiens_hsa030302.68031366
6Allograft rejection_Homo sapiens_hsa053302.44317630
7Biosynthesis of amino acids_Homo sapiens_hsa012302.30926934
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.25000135
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.19254711
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.15350049
11Autoimmune thyroid disease_Homo sapiens_hsa053202.13255477
12Graft-versus-host disease_Homo sapiens_hsa053322.11890312
13Pentose phosphate pathway_Homo sapiens_hsa000302.04571549
14Other glycan degradation_Homo sapiens_hsa005112.02227846
15Asthma_Homo sapiens_hsa053101.92063757
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.83827097
17Type I diabetes mellitus_Homo sapiens_hsa049401.63684733
18Leishmaniasis_Homo sapiens_hsa051401.63489701
19Viral myocarditis_Homo sapiens_hsa054161.61624636
20B cell receptor signaling pathway_Homo sapiens_hsa046621.54913266
21Carbon metabolism_Homo sapiens_hsa012001.50697322
22Spliceosome_Homo sapiens_hsa030401.47676667
23Herpes simplex infection_Homo sapiens_hsa051681.47325566
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.46921469
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37219205
26Staphylococcus aureus infection_Homo sapiens_hsa051501.36479691
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32740117
28Epstein-Barr virus infection_Homo sapiens_hsa051691.30801327
29Antigen processing and presentation_Homo sapiens_hsa046121.30268487
30Osteoclast differentiation_Homo sapiens_hsa043801.27353028
31Notch signaling pathway_Homo sapiens_hsa043301.26696237
32Shigellosis_Homo sapiens_hsa051311.26221969
33Galactose metabolism_Homo sapiens_hsa000521.24666765
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20879617
35Systemic lupus erythematosus_Homo sapiens_hsa053221.19771072
36Mismatch repair_Homo sapiens_hsa034301.15796277
37Fructose and mannose metabolism_Homo sapiens_hsa000511.15731972
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15514092
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.12525426
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10903776
41Influenza A_Homo sapiens_hsa051641.09372262
42Acute myeloid leukemia_Homo sapiens_hsa052211.09186848
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.08366646
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07012242
45Tuberculosis_Homo sapiens_hsa051521.03372299
46mRNA surveillance pathway_Homo sapiens_hsa030151.02124678
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99202965
48Apoptosis_Homo sapiens_hsa042100.98714816
49Lysosome_Homo sapiens_hsa041420.91834369
50Rheumatoid arthritis_Homo sapiens_hsa053230.91449871
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.87309460
52Pyrimidine metabolism_Homo sapiens_hsa002400.86463687
53Salmonella infection_Homo sapiens_hsa051320.85770784
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85020803
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83460730
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81069153
57Hematopoietic cell lineage_Homo sapiens_hsa046400.78668643
58Viral carcinogenesis_Homo sapiens_hsa052030.75947169
59Prion diseases_Homo sapiens_hsa050200.74740886
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74606926
61Hepatitis C_Homo sapiens_hsa051600.73528916
62HTLV-I infection_Homo sapiens_hsa051660.72733276
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71042033
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.70254893
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69867519
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69479505
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68873875
68Bladder cancer_Homo sapiens_hsa052190.64897829
69Hepatitis B_Homo sapiens_hsa051610.64432550
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56849603
71Pertussis_Homo sapiens_hsa051330.56742724
72Phagosome_Homo sapiens_hsa041450.53175449
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52979875
74Measles_Homo sapiens_hsa051620.51179645
75Parkinsons disease_Homo sapiens_hsa050120.49027724
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48422240
77Alcoholism_Homo sapiens_hsa050340.48196706
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47781262
79Toxoplasmosis_Homo sapiens_hsa051450.46933491
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44740315
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44526588
82VEGF signaling pathway_Homo sapiens_hsa043700.43991251
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43936411
84TNF signaling pathway_Homo sapiens_hsa046680.43536074
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.42578548
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41859550
87RNA transport_Homo sapiens_hsa030130.41743711
88Glutathione metabolism_Homo sapiens_hsa004800.40624900
89Pyruvate metabolism_Homo sapiens_hsa006200.40536620
90RNA polymerase_Homo sapiens_hsa030200.40464703
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39923479
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.39586626
93Nucleotide excision repair_Homo sapiens_hsa034200.37634642
94T cell receptor signaling pathway_Homo sapiens_hsa046600.36160384
95Legionellosis_Homo sapiens_hsa051340.35103129
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.34283218
97Arginine and proline metabolism_Homo sapiens_hsa003300.34223035
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33059923
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.31810247
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31603434

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