ASNA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)6.19992589
2negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.51049429
3Golgi transport vesicle coating (GO:0048200)5.24072691
4COPI coating of Golgi vesicle (GO:0048205)5.24072691
5regulation of gene silencing by RNA (GO:0060966)5.18223968
6regulation of posttranscriptional gene silencing (GO:0060147)5.18223968
7regulation of gene silencing by miRNA (GO:0060964)5.18223968
8folic acid-containing compound biosynthetic process (GO:0009396)4.87012839
9formation of translation preinitiation complex (GO:0001731)4.84777086
10regulation of translational fidelity (GO:0006450)4.58933616
11nuclear pore organization (GO:0006999)4.56525093
12regulation of translational termination (GO:0006449)4.49958395
13heterochromatin organization (GO:0070828)4.47423878
14mitotic nuclear envelope disassembly (GO:0007077)4.38386737
15DNA replication-dependent nucleosome organization (GO:0034723)4.38327398
16DNA replication-dependent nucleosome assembly (GO:0006335)4.38327398
17protein localization to kinetochore (GO:0034501)4.38269348
18DNA unwinding involved in DNA replication (GO:0006268)4.24393768
19nuclear envelope disassembly (GO:0051081)4.16065322
20membrane disassembly (GO:0030397)4.16065322
21nuclear pore complex assembly (GO:0051292)4.14752424
22pre-miRNA processing (GO:0031054)4.12290575
23IMP biosynthetic process (GO:0006188)4.06059500
24pentose-phosphate shunt (GO:0006098)3.96571407
25nucleobase biosynthetic process (GO:0046112)3.92425051
26peptidyl-arginine omega-N-methylation (GO:0035247)3.90729231
27mitotic sister chromatid segregation (GO:0000070)3.90688551
28negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.89435066
29mitotic nuclear envelope reassembly (GO:0007084)3.87356387
30nuclear envelope reassembly (GO:0031468)3.87356387
31histone arginine methylation (GO:0034969)3.87268917
32DNA replication initiation (GO:0006270)3.73286404
33deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.67254197
34protein retention in ER lumen (GO:0006621)3.66466362
35positive regulation of SMAD protein import into nucleus (GO:0060391)3.65299096
36GDP-mannose metabolic process (GO:0019673)3.64628379
37nucleobase-containing small molecule interconversion (GO:0015949)3.63776486
38NADPH regeneration (GO:0006740)3.62429120
39paraxial mesoderm development (GO:0048339)3.60739361
40DNA strand elongation involved in DNA replication (GO:0006271)3.60371539
41mitotic metaphase plate congression (GO:0007080)3.60358896
42mitotic G1 DNA damage checkpoint (GO:0031571)3.59310958
43establishment of viral latency (GO:0019043)3.56507721
44protein localization to chromosome, centromeric region (GO:0071459)3.55516273
45sister chromatid segregation (GO:0000819)3.54152974
46protein localization to endosome (GO:0036010)3.51568479
47pinocytosis (GO:0006907)3.49976685
48maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.48520371
49retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.47887828
50purine nucleobase biosynthetic process (GO:0009113)3.47774472
51barbed-end actin filament capping (GO:0051016)3.46964412
52regulation of hippo signaling (GO:0035330)3.46871770
53glucose catabolic process (GO:0006007)3.43861599
54NADH metabolic process (GO:0006734)3.41824680
55ribosome biogenesis (GO:0042254)3.40664997
56establishment of integrated proviral latency (GO:0075713)3.39184011
57IMP metabolic process (GO:0046040)3.39116216
58establishment of apical/basal cell polarity (GO:0035089)3.38792441
59DNA duplex unwinding (GO:0032508)3.36104299
60peptidyl-arginine methylation (GO:0018216)3.35571205
61peptidyl-arginine N-methylation (GO:0035246)3.35571205
62DNA strand elongation (GO:0022616)3.35357266
63DNA geometric change (GO:0032392)3.35348153
64nuclear envelope organization (GO:0006998)3.34755055
65ribosome assembly (GO:0042255)3.34117482
66histone H4-K12 acetylation (GO:0043983)3.33478399
67regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.33185949
68endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.33156339
69pentose metabolic process (GO:0019321)3.31817392
70regulation of mammary gland epithelial cell proliferation (GO:0033599)3.31339010
71pore complex assembly (GO:0046931)3.30512983
72somatic hypermutation of immunoglobulin genes (GO:0016446)3.29822168
73somatic diversification of immune receptors via somatic mutation (GO:0002566)3.29822168
74mitochondrial fusion (GO:0008053)3.28152395
75spliceosomal tri-snRNP complex assembly (GO:0000244)3.27903022
76DNA replication checkpoint (GO:0000076)3.26925508
77folic acid metabolic process (GO:0046655)3.24196295
78regulation of spindle organization (GO:0090224)3.20665478
79positive regulation of chromosome segregation (GO:0051984)3.17896534
80chromatin assembly (GO:0031497)3.17428914
81regulation of SMAD protein import into nucleus (GO:0060390)3.16228728
82regulation of telomere maintenance via telomerase (GO:0032210)3.14491422
83regulation of mitotic spindle organization (GO:0060236)3.14124020
84telomere maintenance via semi-conservative replication (GO:0032201)3.12148068
85proline biosynthetic process (GO:0006561)3.09551343
86mitotic G1/S transition checkpoint (GO:0044819)3.09337127
87apoptotic process involved in morphogenesis (GO:0060561)3.04859722
88positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.04189323
89chaperone-mediated protein complex assembly (GO:0051131)3.00517073
90negative regulation of histone methylation (GO:0031061)3.00348674
91trophectodermal cell differentiation (GO:0001829)2.97488750
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95410437
93dosage compensation (GO:0007549)2.93314671
94regulation of mitochondrial membrane potential (GO:0051881)2.92052179
95mitochondrial DNA metabolic process (GO:0032042)2.90177253
96negative regulation of ligase activity (GO:0051352)2.89692609
97negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89692609
98regulation of sister chromatid cohesion (GO:0007063)2.89253092
99negative regulation of cell size (GO:0045792)2.89237277
100nodal signaling pathway (GO:0038092)2.88800512
101pyrimidine-containing compound salvage (GO:0008655)2.88649486
102pyrimidine nucleoside salvage (GO:0043097)2.88649486
103mitotic chromosome condensation (GO:0007076)2.88499341
104virion assembly (GO:0019068)2.88112650
105regulation of cellular amino acid metabolic process (GO:0006521)2.87010855
106regulation of translational elongation (GO:0006448)2.86330155
107establishment of monopolar cell polarity (GO:0061162)2.86181363
108establishment or maintenance of monopolar cell polarity (GO:0061339)2.86181363
109negative regulation of chromosome segregation (GO:0051985)2.86048905
110UV protection (GO:0009650)2.86014859
111regulation of centrosome cycle (GO:0046605)2.85836957
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.84902462
113metaphase plate congression (GO:0051310)2.84398267
114regulation of gene silencing (GO:0060968)2.83752172
115anterior/posterior axis specification, embryo (GO:0008595)2.83054972
116determination of adult lifespan (GO:0008340)2.82784103
117positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.81666110
118regulation of chromosome segregation (GO:0051983)2.80478820
119regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.80116307
120guanosine-containing compound biosynthetic process (GO:1901070)2.78295876
121regulation of mitochondrial translation (GO:0070129)2.78271187
122maternal placenta development (GO:0001893)2.77749363
123negative regulation of gene silencing (GO:0060969)2.76697533
124antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.75757618
125G1 DNA damage checkpoint (GO:0044783)2.75372741
126positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.74488863
127positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.74488863
128positive regulation of mitotic sister chromatid separation (GO:1901970)2.74488863
129tetrahydrofolate metabolic process (GO:0046653)2.74228522
130positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.72954672
131regulation of early endosome to late endosome transport (GO:2000641)2.72414375
132maturation of SSU-rRNA (GO:0030490)2.72058758
133regulation of superoxide anion generation (GO:0032928)2.70756575
134NIK/NF-kappaB signaling (GO:0038061)2.70633021
135regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.70552269
136pteridine-containing compound biosynthetic process (GO:0042559)2.69398325
137negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.69169205
138regulation of histone H3-K9 methylation (GO:0051570)2.68338597
139mitochondrial calcium ion transport (GO:0006851)2.68221778
140histone H2A monoubiquitination (GO:0035518)2.65898914
141ribonucleoprotein complex biogenesis (GO:0022613)2.64971698
142positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.64341746
143protein complex localization (GO:0031503)2.64266868
144tRNA aminoacylation for protein translation (GO:0006418)2.64172468
145negative regulation of mitotic sister chromatid separation (GO:2000816)2.64144017
146negative regulation of mitotic sister chromatid segregation (GO:0033048)2.64144017
147negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.64144017
148negative regulation of sister chromatid segregation (GO:0033046)2.64144017
149DNA deamination (GO:0045006)2.63304953
150viral protein processing (GO:0019082)2.62918217
151regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.62845507
152heme biosynthetic process (GO:0006783)2.62406989
153anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.60155964
1542-deoxyribonucleotide biosynthetic process (GO:0009265)2.58162817
155deoxyribose phosphate biosynthetic process (GO:0046385)2.58162817
156glycosphingolipid catabolic process (GO:0046479)2.55858547
157positive regulation of Cdc42 GTPase activity (GO:0043089)2.55705721
158protein targeting to mitochondrion (GO:0006626)2.54490540
159negative regulation of mitochondrion organization (GO:0010823)2.53617537
160DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.53449924
161cellular response to arsenic-containing substance (GO:0071243)2.51481686
162monosaccharide biosynthetic process (GO:0046364)2.50825036
163signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.48481680
164intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.48481680
165positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.46272695
166signal transduction involved in DNA integrity checkpoint (GO:0072401)2.45286418
167signal transduction involved in DNA damage checkpoint (GO:0072422)2.45286418
168ribosomal small subunit biogenesis (GO:0042274)2.44642229
169activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.44001937
170amino sugar catabolic process (GO:0046348)2.41743230
171de novo protein folding (GO:0006458)2.41543148
172regulation of release of cytochrome c from mitochondria (GO:0090199)2.40950852
173signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.40658800
174signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.40658800
175signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.40658800
176de novo posttranslational protein folding (GO:0051084)2.40563859
177nucleotide salvage (GO:0043173)2.40560224
178glucose 6-phosphate metabolic process (GO:0051156)2.40058771
179activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.39491786
180rRNA transcription (GO:0009303)2.39276440
181positive regulation of nuclease activity (GO:0032075)2.38661716
182iron-sulfur cluster assembly (GO:0016226)2.38408798
183metallo-sulfur cluster assembly (GO:0031163)2.38408798
184chaperone-mediated protein transport (GO:0072321)2.36851645
185nucleoside salvage (GO:0043174)2.36553781
186positive regulation of ligase activity (GO:0051351)2.36142436
187deoxyribonucleotide biosynthetic process (GO:0009263)2.36133311
188hydrogen peroxide catabolic process (GO:0042744)2.35473088
189proteasome assembly (GO:0043248)2.34404194
190signal transduction involved in cell cycle checkpoint (GO:0072395)2.34256076
191amyloid precursor protein catabolic process (GO:0042987)2.34211526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.09623022
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.81903780
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.55229489
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.46321157
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86945845
6POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.51849183
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.51133470
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48053074
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39368998
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32786506
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30871705
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.25585072
13NANOG_18555785_ChIP-Seq_MESCs_Mouse2.12265934
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10428841
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.09221412
16MYC_22102868_ChIP-Seq_BL_Human2.08826665
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08776568
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.08548621
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.08548621
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.08548621
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06727260
22STAT3_1855785_ChIP-Seq_MESCs_Mouse2.04891726
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04068342
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02278736
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.00072597
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96697733
27XRN2_22483619_ChIP-Seq_HELA_Human1.92147048
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.90972383
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81035874
30KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.80204215
31NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.80186427
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76328450
33* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73127981
34TCF3_18692474_ChIP-Seq_MEFs_Mouse1.71210426
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68748063
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68109363
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66533614
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.66486566
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.65041991
40* EST1_17652178_ChIP-ChIP_JURKAT_Human1.60456997
41AR_21909140_ChIP-Seq_LNCAP_Human1.59789624
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59526287
43KLF4_18555785_ChIP-Seq_MESCs_Mouse1.58709314
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.56518566
45SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56474044
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.55597729
47* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54446196
48* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53405627
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52440900
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50483114
51* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49539098
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49128578
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46982021
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46576220
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46315312
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45721888
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45165854
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44987871
59GABP_19822575_ChIP-Seq_HepG2_Human1.44141697
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44062959
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41714476
62SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.41710531
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41569077
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41139689
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41063435
66HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.39419638
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39213797
68ZNF263_19887448_ChIP-Seq_K562_Human1.38010981
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37054572
70TCF3_18692474_ChIP-Seq_MESCs_Mouse1.37013590
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36550219
72KDM5A_27292631_Chip-Seq_BREAST_Human1.35058166
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.34840514
74TP63_17297297_ChIP-ChIP_HaCaT_Human1.33958464
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33547149
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32036383
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.30865461
78OCT4_18692474_ChIP-Seq_MEFs_Mouse1.30693887
79DCP1A_22483619_ChIP-Seq_HELA_Human1.29603008
80* TFEB_21752829_ChIP-Seq_HELA_Human1.28922996
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28474426
82SOX2_18692474_ChIP-Seq_MEFs_Mouse1.27632059
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.27466176
84GABP_17652178_ChIP-ChIP_JURKAT_Human1.27195767
85P68_20966046_ChIP-Seq_HELA_Human1.26895570
86* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26538695
87CIITA_25753668_ChIP-Seq_RAJI_Human1.23459665
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21928003
89* TTF2_22483619_ChIP-Seq_HELA_Human1.20667125
90VDR_21846776_ChIP-Seq_THP-1_Human1.20073738
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19195841
92CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19114860
93* VDR_23849224_ChIP-Seq_CD4+_Human1.18683190
94NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.17508628
95POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17298241
96SOX2_18692474_ChIP-Seq_MESCs_Mouse1.16848453
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16548793
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16374045
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15687842
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15446191
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15001398
102SRF_21415370_ChIP-Seq_HL-1_Mouse1.14168203
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13647284
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12877973
105ATF3_27146783_Chip-Seq_COLON_Human1.12655580
106CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12077117
107GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11441721
108* FOXP3_21729870_ChIP-Seq_TREG_Human1.11215168
109ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11120686
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10120801
111SA1_27219007_Chip-Seq_ERYTHROID_Human1.09226096
112CLOCK_20551151_ChIP-Seq_293T_Human1.08231436
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08212485
114POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.08111141
115PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07906723
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07836003
117NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.07452466
118TBX5_21415370_ChIP-Seq_HL-1_Mouse1.06827861
119* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05968930
120* BCOR_27268052_Chip-Seq_Bcells_Human1.05834899
121UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05399028
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04075477
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03921739
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03572932
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03306022
126CTCF_26484167_Chip-Seq_Bcells_Mouse1.02820861
127ELK3_25401928_ChIP-Seq_HUVEC_Human1.02782997
128TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02777933
129NANOG_18692474_ChIP-Seq_MEFs_Mouse1.02468699
130KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01909501
131* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00920733
132KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00622615
133HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00413408
134CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00352468
135SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99429893
136BCL6_27268052_Chip-Seq_Bcells_Human0.98624418
137CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98567381
138CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95449863
139BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95002269
140SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94982686
141RACK7_27058665_Chip-Seq_MCF-7_Human0.94898836
142LXR_22292898_ChIP-Seq_THP-1_Human0.92256779
143ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91542416
144NANOG_18692474_ChIP-Seq_MESCs_Mouse0.91041235
145KAP1_27257070_Chip-Seq_ESCs_Mouse0.89413105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.85292631
2MP0004957_abnormal_blastocyst_morpholog3.94934231
3MP0003693_abnormal_embryo_hatching3.94364334
4MP0003111_abnormal_nucleus_morphology3.77490831
5MP0010352_gastrointestinal_tract_polyps3.74767792
6MP0008260_abnormal_autophagy3.32746554
7MP0003705_abnormal_hypodermis_morpholog3.23657575
8MP0010094_abnormal_chromosome_stability3.17750764
9MP0003077_abnormal_cell_cycle3.09882677
10MP0002653_abnormal_ependyma_morphology3.07175014
11MP0005451_abnormal_body_composition3.05595833
12MP0001730_embryonic_growth_arrest2.79949751
13MP0003191_abnormal_cellular_cholesterol2.53195794
14MP0005076_abnormal_cell_differentiation2.44568152
15MP0003806_abnormal_nucleotide_metabolis2.43523824
16MP0010307_abnormal_tumor_latency2.42305935
17MP0003283_abnormal_digestive_organ2.38155510
18MP0003123_paternal_imprinting2.37691805
19MP0008057_abnormal_DNA_replication2.30143344
20MP0003303_peritoneal_inflammation2.29596409
21MP0000350_abnormal_cell_proliferation2.28893563
22MP0005464_abnormal_platelet_physiology2.15495589
23MP0009333_abnormal_splenocyte_physiolog2.11273197
24MP0001672_abnormal_embryogenesis/_devel2.09647186
25MP0005380_embryogenesis_phenotype2.09647186
26MP0008932_abnormal_embryonic_tissue2.04919373
27MP0001697_abnormal_embryo_size2.01542188
28MP0004510_myositis2.01124317
29MP0002084_abnormal_developmental_patter1.99389460
30MP0010030_abnormal_orbit_morphology1.97627182
31MP0002085_abnormal_embryonic_tissue1.95497644
32MP0004233_abnormal_muscle_weight1.95404405
33MP0004197_abnormal_fetal_growth/weight/1.94773886
34MP0003075_altered_response_to1.94342052
35MP0000343_altered_response_to1.93940137
36MP0003984_embryonic_growth_retardation1.89124391
37MP0004133_heterotaxia1.88186918
38MP0003329_amyloid_beta_deposits1.87447635
39MP0002088_abnormal_embryonic_growth/wei1.86462144
40MP0005257_abnormal_intraocular_pressure1.86425270
41MP0002086_abnormal_extraembryonic_tissu1.86162815
42* MP0002080_prenatal_lethality1.82638961
43MP0003566_abnormal_cell_adhesion1.80825527
44MP0002796_impaired_skin_barrier1.79250770
45MP0008007_abnormal_cellular_replicative1.78832663
46MP0003119_abnormal_digestive_system1.77830631
47MP0008058_abnormal_DNA_repair1.76800329
48MP0001849_ear_inflammation1.70062641
49MP0003436_decreased_susceptibility_to1.56706115
50MP0003890_abnormal_embryonic-extraembry1.56169669
51MP0005165_increased_susceptibility_to1.53532216
52MP0008438_abnormal_cutaneous_collagen1.49523309
53MP0000604_amyloidosis1.42386663
54MP0002269_muscular_atrophy1.41523831
55MP0006036_abnormal_mitochondrial_physio1.40909846
56MP0001853_heart_inflammation1.39467381
57MP0001293_anophthalmia1.36771242
58MP0002877_abnormal_melanocyte_morpholog1.36275037
59MP0006035_abnormal_mitochondrial_morpho1.35398780
60MP0002254_reproductive_system_inflammat1.34310911
61MP0002148_abnormal_hypersensitivity_rea1.32108108
62MP0004947_skin_inflammation1.31994627
63MP0005023_abnormal_wound_healing1.31724936
64MP0000750_abnormal_muscle_regeneration1.31097771
65MP0004858_abnormal_nervous_system1.26361856
66MP0000313_abnormal_cell_death1.25857631
67MP0005623_abnormal_meninges_morphology1.25613819
68MP0009053_abnormal_anal_canal1.25302414
69MP0005397_hematopoietic_system_phenotyp1.22044503
70MP0001545_abnormal_hematopoietic_system1.22044503
71MP0000537_abnormal_urethra_morphology1.20502620
72MP0000358_abnormal_cell_content/1.18815866
73MP0003567_abnormal_fetal_cardiomyocyte1.17852337
74MP0009840_abnormal_foam_cell1.16717217
75MP0005330_cardiomyopathy1.16143659
76MP0001542_abnormal_bone_strength1.15778067
77MP0001727_abnormal_embryo_implantation1.13999838
78MP0003786_premature_aging1.12865343
79MP0000749_muscle_degeneration1.12576131
80MP0004264_abnormal_extraembryonic_tissu1.11615784
81MP0002060_abnormal_skin_morphology1.11142675
82MP0009672_abnormal_birth_weight1.11123963
83MP0010234_abnormal_vibrissa_follicle1.06882209
84MP0000490_abnormal_crypts_of1.06663334
85MP0002019_abnormal_tumor_incidence1.06559423
86MP0000003_abnormal_adipose_tissue1.05629135
87MP0000733_abnormal_muscle_development1.04915104
88MP0009278_abnormal_bone_marrow1.03979574
89MP0009703_decreased_birth_body1.02922514
90MP0002111_abnormal_tail_morphology1.02076682
91MP0001661_extended_life_span1.01605309
92MP0001216_abnormal_epidermal_layer1.01191684
93MP0000751_myopathy1.00214509
94MP0000678_abnormal_parathyroid_gland0.99148208
95MP0008877_abnormal_DNA_methylation0.98521819
96MP0001533_abnormal_skeleton_physiology0.96807657
97MP0001243_abnormal_dermal_layer0.93159364
98MP0000428_abnormal_craniofacial_morphol0.92640319
99MP0005384_cellular_phenotype0.92506422
100MP0005621_abnormal_cell_physiology0.92309145
101MP0005083_abnormal_biliary_tract0.91969533
102MP0004185_abnormal_adipocyte_glucose0.91830435
103MP0003221_abnormal_cardiomyocyte_apopto0.91003097
104MP0004808_abnormal_hematopoietic_stem0.90330335
105MP0004084_abnormal_cardiac_muscle0.90267352
106MP0003300_gastrointestinal_ulcer0.89796402
107MP0008770_decreased_survivor_rate0.88394372
108MP0005266_abnormal_metabolism0.88159112
109MP0008874_decreased_physiological_sensi0.87673823
110MP0005025_abnormal_response_to0.86645917
111MP0002419_abnormal_innate_immunity0.85628541
112MP0000371_diluted_coat_color0.85058235
113MP0005377_hearing/vestibular/ear_phenot0.84729500
114MP0003878_abnormal_ear_physiology0.84729500
115MP0001915_intracranial_hemorrhage0.84572400
116MP0003718_maternal_effect0.82826954
117MP0005166_decreased_susceptibility_to0.82763476
118MP0005319_abnormal_enzyme/_coenzyme0.82431207
119MP0001145_abnormal_male_reproductive0.81516287
120MP0005375_adipose_tissue_phenotype0.81324006
121MP0001348_abnormal_lacrimal_gland0.80749134
122MP0003172_abnormal_lysosome_physiology0.80442832
123MP0006082_CNS_inflammation0.80276344
124MP0002697_abnormal_eye_size0.78537223
125MP0009931_abnormal_skin_appearance0.78042899
126MP0005584_abnormal_enzyme/coenzyme_acti0.77349145
127MP0003941_abnormal_skin_development0.77183264
128MP0000681_abnormal_thyroid_gland0.77080072
129MP0002332_abnormal_exercise_endurance0.76793680
130MP0003121_genomic_imprinting0.76771103
131MP0000858_altered_metastatic_potential0.76301046
132MP0004272_abnormal_basement_membrane0.76010347
133MP0002925_abnormal_cardiovascular_devel0.75794927
134MP0003656_abnormal_erythrocyte_physiolo0.75322222
135MP0005000_abnormal_immune_tolerance0.73493852
136MP0000759_abnormal_skeletal_muscle0.73307356
137MP0003634_abnormal_glial_cell0.72778564
138MP0002092_abnormal_eye_morphology0.72614639
139MP0002210_abnormal_sex_determination0.72309077
140MP0010630_abnormal_cardiac_muscle0.71514832
141MP0004087_abnormal_muscle_fiber0.71030980
142MP0000747_muscle_weakness0.70980527
143MP0003115_abnormal_respiratory_system0.69927545
144MP0003861_abnormal_nervous_system0.69772356
145MP0000266_abnormal_heart_morphology0.69451919
146MP0000534_abnormal_ureter_morphology0.69347343
147MP0005501_abnormal_skin_physiology0.65916527
148MP0003453_abnormal_keratinocyte_physiol0.64198888
149MP0003186_abnormal_redox_activity0.63086562
150MP0005367_renal/urinary_system_phenotyp0.61493616
151MP0000516_abnormal_urinary_system0.61493616
152MP0008961_abnormal_basal_metabolism0.59381517
153MP0000432_abnormal_head_morphology0.59097196
154MP0000477_abnormal_intestine_morphology0.58464743
155MP0002089_abnormal_postnatal_growth/wei0.58429544
156MP0003448_altered_tumor_morphology0.58310201
157MP0005666_abnormal_adipose_tissue0.55972536

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.77707422
2Abnormality of liposaccharide metabolism (HP:0010968)4.27908536
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.27908536
4Abnormality of glycolipid metabolism (HP:0010969)4.27908536
5Vertebral compression fractures (HP:0002953)4.09008562
6Abnormality of the astrocytes (HP:0100707)4.07728514
7Astrocytoma (HP:0009592)4.07728514
8Abnormality of the lower motor neuron (HP:0002366)3.62514855
9Selective tooth agenesis (HP:0001592)3.53791035
10Multiple enchondromatosis (HP:0005701)3.51770355
11Ragged-red muscle fibers (HP:0003200)3.31854510
12Abnormality of the labia minora (HP:0012880)3.24599257
13Distal lower limb muscle weakness (HP:0009053)3.14037581
14Glioma (HP:0009733)3.12832394
15Hand muscle atrophy (HP:0009130)3.12274750
16Abnormal gallbladder physiology (HP:0012438)3.05622758
17Cholecystitis (HP:0001082)3.05622758
18Increased cerebral lipofuscin (HP:0011813)3.03458073
19Degeneration of anterior horn cells (HP:0002398)3.02967023
20Abnormality of the anterior horn cell (HP:0006802)3.02967023
21Breast hypoplasia (HP:0003187)3.01600835
22Rhabdomyosarcoma (HP:0002859)2.99219879
23Vacuolated lymphocytes (HP:0001922)2.98230181
24Aplasia/hypoplasia of the humerus (HP:0006507)2.98029741
25Rib fusion (HP:0000902)2.94598151
26Dysostosis multiplex (HP:0000943)2.89675445
27Adenoma sebaceum (HP:0009720)2.87166206
28Angiofibromas (HP:0010615)2.87166206
29Premature rupture of membranes (HP:0001788)2.86682440
30Short humerus (HP:0005792)2.84458402
31Trismus (HP:0000211)2.79430934
32Spinal muscular atrophy (HP:0007269)2.76783393
33Upper limb amyotrophy (HP:0009129)2.75050036
34Distal upper limb amyotrophy (HP:0007149)2.75050036
35Birth length less than 3rd percentile (HP:0003561)2.71128016
36Medulloblastoma (HP:0002885)2.70136594
37Neoplasm of striated muscle (HP:0009728)2.69132152
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.68706045
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.68706045
40Prolonged neonatal jaundice (HP:0006579)2.67224984
41Missing ribs (HP:0000921)2.66495743
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.65495643
43Carpal bone hypoplasia (HP:0001498)2.61307847
44Centrally nucleated skeletal muscle fibers (HP:0003687)2.60938094
45Spastic diplegia (HP:0001264)2.58935724
46Petechiae (HP:0000967)2.57178758
47Loss of speech (HP:0002371)2.55012846
48Abdominal situs inversus (HP:0003363)2.52244685
49Abnormality of abdominal situs (HP:0011620)2.52244685
50Axonal loss (HP:0003447)2.50155010
51Colon cancer (HP:0003003)2.47974631
52Hepatosplenomegaly (HP:0001433)2.47589896
53Abnormal trabecular bone morphology (HP:0100671)2.46032501
54Microvesicular hepatic steatosis (HP:0001414)2.45871755
55Agnosia (HP:0010524)2.44084282
56Absent radius (HP:0003974)2.41766093
57Progressive neurologic deterioration (HP:0002344)2.41481572
58Insomnia (HP:0100785)2.40308258
59Patellar aplasia (HP:0006443)2.40286265
60Hypokinesia (HP:0002375)2.39968565
61Neoplasm of the oral cavity (HP:0100649)2.39481573
62Upper motor neuron abnormality (HP:0002127)2.39162429
63Metaphyseal cupping (HP:0003021)2.34013243
64Abnormality of polysaccharide metabolism (HP:0011012)2.30113661
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.30113661
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.30113661
67J-shaped sella turcica (HP:0002680)2.29258727
68Atrophy/Degeneration involving motor neurons (HP:0007373)2.27003160
69Generalized amyotrophy (HP:0003700)2.26357152
70Shawl scrotum (HP:0000049)2.25769411
71Testicular atrophy (HP:0000029)2.24247168
72Distal lower limb amyotrophy (HP:0008944)2.23957368
73Aplasia involving forearm bones (HP:0009822)2.23722969
74Absent forearm bone (HP:0003953)2.23722969
75Basal cell carcinoma (HP:0002671)2.23470096
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.22163637
77Abnormality of the distal phalanges of the toes (HP:0010182)2.21793108
78Cerebral aneurysm (HP:0004944)2.21650656
79Short nail (HP:0001799)2.21544518
80Cerebral hypomyelination (HP:0006808)2.21263478
81Aplasia/Hypoplasia of the patella (HP:0006498)2.20899070
82Increased connective tissue (HP:0009025)2.20780919
83Aplasia/Hypoplasia of the sacrum (HP:0008517)2.20254020
84Hyperparathyroidism (HP:0000843)2.19521103
85Impulsivity (HP:0100710)2.16193143
86Abnormality of the motor neurons (HP:0002450)2.15963578
87Abnormal neuron morphology (HP:0012757)2.15963578
88Oral leukoplakia (HP:0002745)2.14619577
89Purpura (HP:0000979)2.13516950
90Achilles tendon contracture (HP:0001771)2.13413592
91Abnormality of the umbilical cord (HP:0010881)2.11663914
92Difficulty climbing stairs (HP:0003551)2.11641551
93Increased serum ferritin (HP:0003281)2.08980444
94Nuclear cataract (HP:0100018)2.08778141
95Premature ovarian failure (HP:0008209)2.08507047
96Neoplasm of the pancreas (HP:0002894)2.07591649
97Microretrognathia (HP:0000308)2.06665678
98Progressive muscle weakness (HP:0003323)2.06255513
99Muscle fibrillation (HP:0010546)2.05534998
100Increased nuchal translucency (HP:0010880)2.05141764
101Rough bone trabeculation (HP:0100670)2.03870955
102Vertebral fusion (HP:0002948)2.03397753
103High anterior hairline (HP:0009890)2.02198959
104Fibroma (HP:0010614)2.01658598
105Biliary tract neoplasm (HP:0100574)2.01067191
106Genu recurvatum (HP:0002816)2.01058405
107Malignant gastrointestinal tract tumors (HP:0006749)2.00950013
108Gastrointestinal carcinoma (HP:0002672)2.00950013
109Vertebral hypoplasia (HP:0008417)2.00796683
110Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.00796683
111Mucopolysacchariduria (HP:0008155)2.00676082
112Urinary glycosaminoglycan excretion (HP:0003541)2.00676082
113Rectovaginal fistula (HP:0000143)2.00294642
114Rectal fistula (HP:0100590)2.00294642
115Abnormality of macrophages (HP:0004311)1.98727691
116Fused cervical vertebrae (HP:0002949)1.97743026
117Deviation of the thumb (HP:0009603)1.97559480
118Pseudobulbar signs (HP:0002200)1.97169584
119Osteolytic defects of the hand bones (HP:0009699)1.97054124
120Osteolytic defects of the phalanges of the hand (HP:0009771)1.97054124
121Increased intramyocellular lipid droplets (HP:0012240)1.96665173
122Protrusio acetabuli (HP:0003179)1.96480246
123Tongue fasciculations (HP:0001308)1.95900190
124Renal duplication (HP:0000075)1.95711742
125Absent thumb (HP:0009777)1.95386626
126Abnormality of glycolysis (HP:0004366)1.95020243
127Abnormal number of incisors (HP:0011064)1.94603106
128Proximal placement of thumb (HP:0009623)1.94438709
129Ankle contracture (HP:0006466)1.94233296
130Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.93661203
131Abnormality of the Achilles tendon (HP:0005109)1.93455329
132Hyperacusis (HP:0010780)1.93406024
133Ulnar bowing (HP:0003031)1.92070740
134Neuronal loss in central nervous system (HP:0002529)1.91851152
135Cafe-au-lait spot (HP:0000957)1.89523055
136Cortical dysplasia (HP:0002539)1.88276360
137Myopathic facies (HP:0002058)1.88117994
138Reduced subcutaneous adipose tissue (HP:0003758)1.87772254
139Cholelithiasis (HP:0001081)1.87668815
140Increased muscle lipid content (HP:0009058)1.87135005
141Cervical subluxation (HP:0003308)1.86362791
142Vaginal fistula (HP:0004320)1.84870651
143Fibrous tissue neoplasm (HP:0012316)1.83500226
144Diminished motivation (HP:0000745)1.83367965
145Fasciculations (HP:0002380)1.82614206
146Abnormal mitochondria in muscle tissue (HP:0008316)1.81256019
147Personality changes (HP:0000751)1.81233379
148Back pain (HP:0003418)1.80029271
149Orthostatic hypotension (HP:0001278)1.79537454
150Abnormality of the salivary glands (HP:0010286)1.77100169
151Hypertensive crisis (HP:0100735)1.76958683
152Long palpebral fissure (HP:0000637)1.76726232
153Rhabdomyolysis (HP:0003201)1.76027951
154Atresia of the external auditory canal (HP:0000413)1.75947078
155Intestinal polyp (HP:0005266)1.75853236
156Preauricular skin tag (HP:0000384)1.75301629
157Delayed puberty (HP:0000823)1.75103129
158Elbow flexion contracture (HP:0002987)1.74558356
159Entropion (HP:0000621)1.74520535
160Cerebral inclusion bodies (HP:0100314)1.74335952
161EMG: neuropathic changes (HP:0003445)1.74284556
162Shallow orbits (HP:0000586)1.73939565
163Interstitial pulmonary disease (HP:0006530)1.73557064
164Apathy (HP:0000741)1.73366389
165Skin tags (HP:0010609)1.72809982
166Vertebral clefting (HP:0008428)1.72136974
167Short 1st metacarpal (HP:0010034)1.71720465
168Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.71720465
169Uterine neoplasm (HP:0010784)1.71196484
170Reticulocytopenia (HP:0001896)1.70294660
171Increased serum pyruvate (HP:0003542)1.69526255
172Spinal rigidity (HP:0003306)1.69177892
173Spastic paraparesis (HP:0002313)1.68570836
174Growth hormone excess (HP:0000845)1.64310155
175Abnormal gallbladder morphology (HP:0012437)1.62721214
176Myocardial infarction (HP:0001658)1.62371139
177Abnormalities of placenta or umbilical cord (HP:0001194)1.62273366
178Bulbar palsy (HP:0001283)1.61848319
179Athetosis (HP:0002305)1.61687408
180Dysautonomia (HP:0002459)1.61141225
181Opisthotonus (HP:0002179)1.60964531
182Fatigue (HP:0012378)1.60903799
183Abnormality of aromatic amino acid family metabolism (HP:0004338)1.60428658

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK13.54413095
2CDK123.37740278
3IRAK33.36673133
4VRK23.23626486
5SMG13.07633792
6BUB12.79805907
7EPHA22.75916209
8CDC72.72057219
9TRIB32.63581655
10WEE12.62491949
11PKN22.37220656
12NEK22.35757915
13SCYL22.29162715
14TESK22.21177887
15EEF2K2.07566382
16ICK2.04708095
17TTK2.02179416
18MAP3K101.93915737
19PRPF4B1.86204513
20STK161.80718037
21ALK1.66791952
22PLK11.65129381
23TESK11.63458421
24PAK41.62713118
25LATS21.60348206
26RPS6KB21.50867379
27CDK71.50602635
28SIK11.49342612
29BMX1.48902646
30LMTK21.46034920
31PASK1.40761180
32TSSK61.40674412
33DDR21.38036932
34KDR1.37512650
35MAP3K81.32144666
36MAP3K31.30540402
37PDGFRA1.29353174
38RIPK11.29185952
39TYRO31.28575140
40ABL21.27241326
41ERN11.22908799
42AURKA1.22150213
43PRKD31.17248526
44EIF2AK11.16168437
45MTOR1.15254317
46TBK11.15243534
47MAPKAPK31.14085515
48PBK1.14023196
49MAP3K111.13062074
50PDK41.09916112
51PDK31.09916112
52BRSK11.09075519
53CHEK21.06658373
54BRSK21.05922903
55CDK41.04100624
56AURKB1.03700012
57TLK11.03518764
58CHEK11.03027980
59TTN1.02037326
60MST1R1.01543772
61MAP3K90.99597673
62ATR0.99318409
63LATS10.98592790
64PLK30.96179856
65STK100.92861266
66LRRK20.90771645
67KSR20.88543060
68CDK20.84704178
69BCKDK0.83654802
70FLT30.82910221
71CDK60.79837343
72IRAK20.77430607
73PAK10.76624116
74DYRK30.75521490
75MAP3K10.75413561
76PRKCI0.75131703
77TAOK10.74335950
78PIM10.71861905
79PIM20.71055838
80AKT30.70390424
81NME20.69799898
82MOS0.69363052
83BRAF0.69147529
84MET0.68498331
85DAPK10.66675808
86RPS6KA40.64705471
87PRKD20.64593692
88AKT20.64053660
89MAP3K120.63727726
90SRPK10.61748575
91NTRK10.60199015
92PRKG20.59120208
93DAPK30.57933989
94EPHB20.56252476
95STK38L0.55756539
96PTK20.55572958
97DYRK1B0.55353092
98LIMK10.55125736
99SIK30.54002137
100ATM0.53311001
101CAMK2G0.52750075
102PDK20.52630735
103CSNK1E0.52018450
104PAK60.51845822
105ACVR1B0.51708791
106ARAF0.50683435
107RAF10.50612348
108CDK10.50123829
109TAOK20.49733852
110STK40.49403698
111MAP3K50.48914349
112GRK60.48794927
113MYLK0.48545922
114PTK60.48410210
115MATK0.48221609
116ERBB40.47980692
117BRD40.47903275
118ILK0.47152556
119PDPK10.46615209
120FGFR10.46405174
121RPS6KA10.45711236
122STK380.44453573
123CSNK2A20.43804552
124MAP2K30.43396926
125EPHB10.43144308
126PAK20.43067424
127MAPKAPK20.42897648
128CDC42BPA0.40931080
129CDK140.40523629
130CSNK1G30.40428438
131MAP4K10.39236338
132MAPK110.38943718
133PLK40.38469163
134STK30.38307099
135CDK80.38250800
136MAP2K20.36881035
137IRAK40.36594807
138CDK11A0.36519306
139RPS6KA20.33940351
140CDK150.33432023
141ZAP700.32091053
142CDK180.31127070
143ROCK20.28763853
144GSK3A0.25273646

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.00756676
2Mismatch repair_Homo sapiens_hsa034303.63262646
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.40723203
4RNA transport_Homo sapiens_hsa030133.27020575
5One carbon pool by folate_Homo sapiens_hsa006703.09533234
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.05909476
7Spliceosome_Homo sapiens_hsa030402.74774349
8Other glycan degradation_Homo sapiens_hsa005112.71890192
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.60488999
10Base excision repair_Homo sapiens_hsa034102.56478863
11Cell cycle_Homo sapiens_hsa041102.29030371
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.27192639
13Biosynthesis of amino acids_Homo sapiens_hsa012302.18463420
14Nucleotide excision repair_Homo sapiens_hsa034202.09042917
15Proteasome_Homo sapiens_hsa030501.96983715
16Vibrio cholerae infection_Homo sapiens_hsa051101.95978746
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.91446770
18Fatty acid elongation_Homo sapiens_hsa000621.87494690
19mRNA surveillance pathway_Homo sapiens_hsa030151.86963490
20RNA polymerase_Homo sapiens_hsa030201.77090011
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64880926
22Homologous recombination_Homo sapiens_hsa034401.62793458
23p53 signaling pathway_Homo sapiens_hsa041151.61872554
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.61731670
25Carbon metabolism_Homo sapiens_hsa012001.54771071
26Ribosome_Homo sapiens_hsa030101.53872092
27N-Glycan biosynthesis_Homo sapiens_hsa005101.44703536
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.40232059
29Sulfur metabolism_Homo sapiens_hsa009201.38510974
30Pyrimidine metabolism_Homo sapiens_hsa002401.38381396
31mTOR signaling pathway_Homo sapiens_hsa041501.36813786
32Fructose and mannose metabolism_Homo sapiens_hsa000511.34894784
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.34718322
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.31431631
35Bladder cancer_Homo sapiens_hsa052191.30431868
36Oocyte meiosis_Homo sapiens_hsa041141.30199395
37Selenocompound metabolism_Homo sapiens_hsa004501.28945458
38Oxidative phosphorylation_Homo sapiens_hsa001901.23118608
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.21801441
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.20000485
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.18558575
42Hippo signaling pathway_Homo sapiens_hsa043901.16898427
43Viral carcinogenesis_Homo sapiens_hsa052031.16208695
44Parkinsons disease_Homo sapiens_hsa050121.14137607
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12413511
46Salmonella infection_Homo sapiens_hsa051321.10989960
47Synaptic vesicle cycle_Homo sapiens_hsa047211.10318509
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09889300
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09733833
50Systemic lupus erythematosus_Homo sapiens_hsa053221.09436558
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07980263
52RNA degradation_Homo sapiens_hsa030181.07801989
53Pentose phosphate pathway_Homo sapiens_hsa000301.02276617
54Sulfur relay system_Homo sapiens_hsa041220.99403890
55Collecting duct acid secretion_Homo sapiens_hsa049660.96713446
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95646003
57Thyroid cancer_Homo sapiens_hsa052160.94729509
58Fanconi anemia pathway_Homo sapiens_hsa034600.93731065
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93702288
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85994818
61Epstein-Barr virus infection_Homo sapiens_hsa051690.85976057
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84851907
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84269764
64Endocytosis_Homo sapiens_hsa041440.84225333
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83954818
66Huntingtons disease_Homo sapiens_hsa050160.83894409
67MicroRNAs in cancer_Homo sapiens_hsa052060.83840823
68Nitrogen metabolism_Homo sapiens_hsa009100.83587563
69Notch signaling pathway_Homo sapiens_hsa043300.81219220
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80673534
71Vitamin B6 metabolism_Homo sapiens_hsa007500.79889166
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79748475
73Galactose metabolism_Homo sapiens_hsa000520.77053827
74Basal cell carcinoma_Homo sapiens_hsa052170.76491329
75HTLV-I infection_Homo sapiens_hsa051660.76369710
76Adherens junction_Homo sapiens_hsa045200.76291739
77Chronic myeloid leukemia_Homo sapiens_hsa052200.73978735
78Alzheimers disease_Homo sapiens_hsa050100.73474528
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72107516
80Tight junction_Homo sapiens_hsa045300.70672847
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68900783
82Hedgehog signaling pathway_Homo sapiens_hsa043400.68645116
83Basal transcription factors_Homo sapiens_hsa030220.67404368
84Sphingolipid metabolism_Homo sapiens_hsa006000.66489995
85Colorectal cancer_Homo sapiens_hsa052100.65117832
86HIF-1 signaling pathway_Homo sapiens_hsa040660.64084280
87Pyruvate metabolism_Homo sapiens_hsa006200.62182516
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62005396
89Endometrial cancer_Homo sapiens_hsa052130.61452480
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61033256
91Folate biosynthesis_Homo sapiens_hsa007900.60703792
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60281607
93Arginine biosynthesis_Homo sapiens_hsa002200.60013649
94Small cell lung cancer_Homo sapiens_hsa052220.59580952
95Alcoholism_Homo sapiens_hsa050340.58001519
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57710824
97Lysine degradation_Homo sapiens_hsa003100.56883491
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56753050
99Pancreatic cancer_Homo sapiens_hsa052120.56438477
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55412900
101Hepatitis C_Homo sapiens_hsa051600.55041458
102Legionellosis_Homo sapiens_hsa051340.54912512
103Non-homologous end-joining_Homo sapiens_hsa034500.54322405
104Phagosome_Homo sapiens_hsa041450.53845535
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53602071
106TGF-beta signaling pathway_Homo sapiens_hsa043500.53277777
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52964816
108Proteoglycans in cancer_Homo sapiens_hsa052050.51728990
109Antigen processing and presentation_Homo sapiens_hsa046120.48165258
110Apoptosis_Homo sapiens_hsa042100.47640057
111VEGF signaling pathway_Homo sapiens_hsa043700.47206651
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.45595695
113Phenylalanine metabolism_Homo sapiens_hsa003600.45368879
114Insulin signaling pathway_Homo sapiens_hsa049100.44875167
115Non-small cell lung cancer_Homo sapiens_hsa052230.44819323
116Hepatitis B_Homo sapiens_hsa051610.44412961
117Purine metabolism_Homo sapiens_hsa002300.43911880
118AMPK signaling pathway_Homo sapiens_hsa041520.43716789
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.42502703
120Arginine and proline metabolism_Homo sapiens_hsa003300.42005523
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40764539
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40714927
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.38945506
124Rheumatoid arthritis_Homo sapiens_hsa053230.38267780
125Osteoclast differentiation_Homo sapiens_hsa043800.37975225
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37216113
127Metabolic pathways_Homo sapiens_hsa011000.36600071
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36256673
129Shigellosis_Homo sapiens_hsa051310.35410901
130Pertussis_Homo sapiens_hsa051330.34894108
131Melanoma_Homo sapiens_hsa052180.33924760
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.33899575
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33744784
134Glioma_Homo sapiens_hsa052140.33533819
135Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32781270
136Acute myeloid leukemia_Homo sapiens_hsa052210.32215447
137Glucagon signaling pathway_Homo sapiens_hsa049220.31180291
138Glutathione metabolism_Homo sapiens_hsa004800.29803820
139Pathways in cancer_Homo sapiens_hsa052000.29441432
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28439727
141Prion diseases_Homo sapiens_hsa050200.28096387
142Lysosome_Homo sapiens_hsa041420.25749661
143Herpes simplex infection_Homo sapiens_hsa051680.25693669

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