ASNSP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication checkpoint (GO:0000076)4.93101895
2tRNA aminoacylation for protein translation (GO:0006418)4.33532021
3amino acid activation (GO:0043038)4.27635040
4tRNA aminoacylation (GO:0043039)4.27635040
5L-serine metabolic process (GO:0006563)4.23784424
6respiratory chain complex IV assembly (GO:0008535)3.93440990
7regulation of meiosis I (GO:0060631)3.76536368
8negative regulation of DNA-dependent DNA replication (GO:2000104)3.72291155
9rRNA modification (GO:0000154)3.66125684
10chromatin remodeling at centromere (GO:0031055)3.63870046
11CENP-A containing nucleosome assembly (GO:0034080)3.62032986
12DNA double-strand break processing (GO:0000729)3.61867382
13replication fork processing (GO:0031297)3.59750679
14cytochrome complex assembly (GO:0017004)3.55903794
15proteasome assembly (GO:0043248)3.53199627
16telomere maintenance via telomerase (GO:0007004)3.49832563
17exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.49180196
18water-soluble vitamin biosynthetic process (GO:0042364)3.45076749
19tetrahydrofolate metabolic process (GO:0046653)3.44269359
20DNA deamination (GO:0045006)3.43888079
21DNA strand elongation involved in DNA replication (GO:0006271)3.43375841
22ribosome assembly (GO:0042255)3.39537273
23regulation of nuclear cell cycle DNA replication (GO:0033262)3.39234736
24purine nucleobase biosynthetic process (GO:0009113)3.38692369
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37910182
26aspartate family amino acid biosynthetic process (GO:0009067)3.36595107
27folic acid-containing compound biosynthetic process (GO:0009396)3.34830468
28telomere maintenance via semi-conservative replication (GO:0032201)3.32413367
29nucleobase biosynthetic process (GO:0046112)3.28311756
30IMP biosynthetic process (GO:0006188)3.28267573
31histone exchange (GO:0043486)3.28119179
32regulation of centriole replication (GO:0046599)3.28019017
33meiotic chromosome segregation (GO:0045132)3.26825711
34negative regulation of DNA recombination (GO:0045910)3.26755111
35protein deneddylation (GO:0000338)3.26444930
36cullin deneddylation (GO:0010388)3.25470411
37synapsis (GO:0007129)3.23762192
38DNA strand elongation (GO:0022616)3.22835606
39DNA catabolic process, exonucleolytic (GO:0000738)3.21652339
40rRNA methylation (GO:0031167)3.21165193
41mitochondrial respiratory chain complex assembly (GO:0033108)3.20722115
42protein-cofactor linkage (GO:0018065)3.20346820
43pteridine-containing compound biosynthetic process (GO:0042559)3.14844175
44tRNA metabolic process (GO:0006399)3.13166789
45regulation of mitochondrial translation (GO:0070129)3.11714181
46ribonucleoprotein complex disassembly (GO:0032988)3.10583628
47serine family amino acid biosynthetic process (GO:0009070)3.08318885
48pseudouridine synthesis (GO:0001522)3.07808531
49protein complex biogenesis (GO:0070271)3.07495541
50telomere maintenance via telomere lengthening (GO:0010833)3.06632993
51regulation of mitotic spindle checkpoint (GO:1903504)3.05068034
52regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.05068034
53nuclear pore complex assembly (GO:0051292)3.04334365
54DNA strand renaturation (GO:0000733)3.03862026
55folic acid-containing compound metabolic process (GO:0006760)3.02632861
56DNA damage response, detection of DNA damage (GO:0042769)3.01344949
57centriole replication (GO:0007099)3.00972231
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00856168
59nuclear pore organization (GO:0006999)2.99430988
60maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99386748
61DNA methylation involved in gamete generation (GO:0043046)2.97760078
62mitotic recombination (GO:0006312)2.96043479
63telomere maintenance via recombination (GO:0000722)2.95255010
64negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.95017754
65DNA replication initiation (GO:0006270)2.94852000
66ribosome biogenesis (GO:0042254)2.91174461
67establishment of protein localization to mitochondrial membrane (GO:0090151)2.90257146
68pteridine-containing compound metabolic process (GO:0042558)2.88454709
69protein K6-linked ubiquitination (GO:0085020)2.88434142
70mitochondrial RNA metabolic process (GO:0000959)2.87010475
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86603755
72mitochondrial respiratory chain complex I assembly (GO:0032981)2.86603755
73NADH dehydrogenase complex assembly (GO:0010257)2.86603755
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.86176420
75RNA-dependent DNA replication (GO:0006278)2.85856147
76organelle disassembly (GO:1903008)2.85600611
77nucleotide-excision repair, DNA gap filling (GO:0006297)2.85248023
78regulation of translational fidelity (GO:0006450)2.84753191
79somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83380565
80somatic hypermutation of immunoglobulin genes (GO:0016446)2.83380565
81RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.83168420
82folic acid metabolic process (GO:0046655)2.83045029
83transcription from mitochondrial promoter (GO:0006390)2.82831987
84regulation of double-strand break repair via homologous recombination (GO:0010569)2.80911452
85IMP metabolic process (GO:0046040)2.80863048
86somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.80297451
87somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.80297451
88isotype switching (GO:0045190)2.80297451
89transcription elongation from RNA polymerase III promoter (GO:0006385)2.79994775
90termination of RNA polymerase III transcription (GO:0006386)2.79994775
91glutamine metabolic process (GO:0006541)2.77852790
92double-strand break repair via nonhomologous end joining (GO:0006303)2.77066220
93non-recombinational repair (GO:0000726)2.77066220
94DNA damage induced protein phosphorylation (GO:0006975)2.75013885
95tRNA processing (GO:0008033)2.74838349
96postreplication repair (GO:0006301)2.73372513
97transcription elongation from RNA polymerase I promoter (GO:0006362)2.70697248
98negative regulation of translational initiation (GO:0045947)2.69996591
99negative regulation of ligase activity (GO:0051352)2.69784683
100negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.69784683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.23666767
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.11302187
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.98051360
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.45368453
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.18379670
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.04934862
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.03985197
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95740946
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.91103903
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.86364920
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71645228
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.69289240
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.63072784
14VDR_22108803_ChIP-Seq_LS180_Human2.51955531
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.51438609
16ELK1_19687146_ChIP-ChIP_HELA_Human2.45924790
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.44007928
18VDR_23849224_ChIP-Seq_CD4+_Human2.34050358
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26162516
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23684844
21ZNF274_21170338_ChIP-Seq_K562_Hela2.20954055
22FOXP3_21729870_ChIP-Seq_TREG_Human2.08801287
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08290823
24FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02440080
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.99933227
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98039970
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.98036184
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92251302
29DCP1A_22483619_ChIP-Seq_HELA_Human1.91726142
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90525133
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.87419276
32GABP_19822575_ChIP-Seq_HepG2_Human1.84369439
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80796367
34TTF2_22483619_ChIP-Seq_HELA_Human1.80445941
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.70638371
36EWS_26573619_Chip-Seq_HEK293_Human1.62274625
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61832031
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60485046
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59546380
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58872165
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58780953
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.56929820
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.55456173
44IGF1R_20145208_ChIP-Seq_DFB_Human1.55058024
45MYC_18940864_ChIP-ChIP_HL60_Human1.54171752
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.52186785
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.48629850
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45457376
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41865789
50XRN2_22483619_ChIP-Seq_HELA_Human1.39188419
51FUS_26573619_Chip-Seq_HEK293_Human1.36423606
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33577201
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32632803
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.31112804
55KDM5A_27292631_Chip-Seq_BREAST_Human1.25928801
56IRF1_19129219_ChIP-ChIP_H3396_Human1.23536692
57AR_21909140_ChIP-Seq_LNCAP_Human1.20763461
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.18016099
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16761519
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12877967
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12765554
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12046445
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08123045
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07745816
65P300_19829295_ChIP-Seq_ESCs_Human1.07419582
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.05996945
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04459349
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03258559
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02382354
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02012822
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98486214
72ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98483189
73TP53_22573176_ChIP-Seq_HFKS_Human0.94403043
74PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94291213
75CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91839925
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91096042
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89900874
78ER_23166858_ChIP-Seq_MCF-7_Human0.89732182
79TAF15_26573619_Chip-Seq_HEK293_Human0.89573003
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88805095
81SOX2_19829295_ChIP-Seq_ESCs_Human0.88529204
82NANOG_19829295_ChIP-Seq_ESCs_Human0.88529204
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87761758
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87545407
85HOXB7_26014856_ChIP-Seq_BT474_Human0.87325310
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87312562
87FOXA1_25329375_ChIP-Seq_VCAP_Human0.86171593
88FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86171593
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85298318
90SOX2_16153702_ChIP-ChIP_HESCs_Human0.84751606
91ZFX_18555785_ChIP-Seq_MESCs_Mouse0.84424961
92PHF8_20622853_ChIP-Seq_HELA_Human0.83633069
93CTBP1_25329375_ChIP-Seq_LNCAP_Human0.80524019
94ELK1_22589737_ChIP-Seq_MCF10A_Human0.79845657
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79623243
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.78930097
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.76148717
98RBPJ_21746931_ChIP-Seq_IB4_Human0.74448327
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.73007585
100PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.72356012

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.86572164
2MP0003890_abnormal_embryonic-extraembry3.41745074
3MP0003693_abnormal_embryo_hatching3.17905263
4MP0010094_abnormal_chromosome_stability3.11516417
5MP0002837_dystrophic_cardiac_calcinosis3.07698843
6MP0003111_abnormal_nucleus_morphology2.84526890
7MP0004957_abnormal_blastocyst_morpholog2.84381527
8MP0008932_abnormal_embryonic_tissue2.56051088
9MP0003786_premature_aging2.52776912
10MP0008877_abnormal_DNA_methylation2.49190040
11MP0002102_abnormal_ear_morphology2.38014461
12MP0008995_early_reproductive_senescence2.35658501
13MP0003646_muscle_fatigue2.28983997
14MP0001529_abnormal_vocalization2.27411130
15MP0004147_increased_porphyrin_level2.25325515
16MP0008057_abnormal_DNA_replication2.11975515
17MP0003718_maternal_effect2.03835448
18MP0008007_abnormal_cellular_replicative1.98059086
19MP0006035_abnormal_mitochondrial_morpho1.93391182
20MP0006072_abnormal_retinal_apoptosis1.85967218
21MP0003077_abnormal_cell_cycle1.78434937
22MP0006036_abnormal_mitochondrial_physio1.78209735
23MP0001188_hyperpigmentation1.75174239
24MP0003941_abnormal_skin_development1.69273109
25MP0001661_extended_life_span1.66197173
26MP0006292_abnormal_olfactory_placode1.64300625
27MP0003195_calcinosis1.64057404
28MP0005645_abnormal_hypothalamus_physiol1.63515758
29MP0008872_abnormal_physiological_respon1.62620907
30MP0003136_yellow_coat_color1.54331057
31MP0002938_white_spotting1.53419210
32MP0005171_absent_coat_pigmentation1.41284772
33MP0002160_abnormal_reproductive_system1.39436856
34MP0002736_abnormal_nociception_after1.38575493
35MP0005410_abnormal_fertilization1.38160585
36MP0009697_abnormal_copulation1.34626579
37MP0003121_genomic_imprinting1.34025002
38MP0003119_abnormal_digestive_system1.32894314
39MP0001929_abnormal_gametogenesis1.28828198
40MP0003806_abnormal_nucleotide_metabolis1.27837849
41MP0006276_abnormal_autonomic_nervous1.27764847
42MP0002210_abnormal_sex_determination1.27686801
43MP0000372_irregular_coat_pigmentation1.26094175
44MP0003567_abnormal_fetal_cardiomyocyte1.17319454
45MP0003937_abnormal_limbs/digits/tail_de1.15999576
46MP0003122_maternal_imprinting1.14932821
47MP0009672_abnormal_birth_weight1.14587108
48MP0010307_abnormal_tumor_latency1.14356675
49MP0005389_reproductive_system_phenotype1.14299747
50MP0001730_embryonic_growth_arrest1.13177261
51MP0002751_abnormal_autonomic_nervous1.12125044
52MP0005646_abnormal_pituitary_gland1.11282341
53MP0001764_abnormal_homeostasis1.11184701
54MP0001145_abnormal_male_reproductive1.10280565
55MP0001697_abnormal_embryo_size1.10019219
56MP0000427_abnormal_hair_cycle1.09259351
57MP0000358_abnormal_cell_content/1.08266191
58MP0003787_abnormal_imprinting1.07770136
59MP0000653_abnormal_sex_gland1.06699959
60MP0005636_abnormal_mineral_homeostasis1.04756777
61MP0009046_muscle_twitch1.03335541
62MP0001968_abnormal_touch/_nociception1.02103070
63MP0003698_abnormal_male_reproductive1.02002083
64MP0002653_abnormal_ependyma_morphology1.01939751
65MP0000647_abnormal_sebaceous_gland0.99507136
66MP0001293_anophthalmia0.98738120
67MP0005253_abnormal_eye_physiology0.98635260
68MP0002254_reproductive_system_inflammat0.95088681
69MP0002084_abnormal_developmental_patter0.93597711
70MP0003137_abnormal_impulse_conducting0.91710661
71MP0003186_abnormal_redox_activity0.91509680
72MP0005083_abnormal_biliary_tract0.90700038
73MP0005670_abnormal_white_adipose0.88630021
74MP0002132_abnormal_respiratory_system0.88267551
75MP0000631_abnormal_neuroendocrine_gland0.88061975
76MP0005084_abnormal_gallbladder_morpholo0.87293685
77MP0005332_abnormal_amino_acid0.87204019
78MP0001672_abnormal_embryogenesis/_devel0.85091435
79MP0005380_embryogenesis_phenotype0.85091435
80MP0001984_abnormal_olfaction0.84975491
81MP0002138_abnormal_hepatobiliary_system0.82643332
82MP0000350_abnormal_cell_proliferation0.82569787
83MP0010352_gastrointestinal_tract_polyps0.82535182
84MP0008875_abnormal_xenobiotic_pharmacok0.82380441
85MP0002272_abnormal_nervous_system0.81756134
86MP0001286_abnormal_eye_development0.81622555
87MP0005551_abnormal_eye_electrophysiolog0.81080844
88MP0001919_abnormal_reproductive_system0.78735855
89MP0002085_abnormal_embryonic_tissue0.78067608
90MP0005395_other_phenotype0.76864947
91MP0002080_prenatal_lethality0.76739103
92MP0009703_decreased_birth_body0.76481255
93MP0000749_muscle_degeneration0.75489049
94MP0000313_abnormal_cell_death0.73684539
95MP0001119_abnormal_female_reproductive0.73160033
96MP0004197_abnormal_fetal_growth/weight/0.72497587
97MP0004133_heterotaxia0.69826572
98MP0002234_abnormal_pharynx_morphology0.65806901
99MP0003221_abnormal_cardiomyocyte_apopto0.65661155
100MP0003283_abnormal_digestive_organ0.63075238

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)4.53442502
2Abnormality of the labia minora (HP:0012880)4.32668717
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.02309291
4Chromsome breakage (HP:0040012)3.93660896
5Birth length less than 3rd percentile (HP:0003561)3.51061641
6Acute necrotizing encephalopathy (HP:0006965)3.47312111
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.47273736
8Acute encephalopathy (HP:0006846)3.37859404
9Hypoplasia of the pons (HP:0012110)3.37106286
10Increased CSF lactate (HP:0002490)3.28786600
11Abnormality of the pons (HP:0007361)3.20288535
12Acanthocytosis (HP:0001927)3.09141446
13Increased hepatocellular lipid droplets (HP:0006565)3.07183373
14Abnormal mitochondria in muscle tissue (HP:0008316)3.05344085
15Hepatocellular necrosis (HP:0001404)3.01892486
16Abnormality of glycolysis (HP:0004366)2.97436695
17Increased serum pyruvate (HP:0003542)2.96737376
18Mitochondrial inheritance (HP:0001427)2.96546739
19Colon cancer (HP:0003003)2.96473732
20Long foot (HP:0001833)2.92709467
21Progressive macrocephaly (HP:0004481)2.89803418
22Hepatic necrosis (HP:0002605)2.89566045
23Lipid accumulation in hepatocytes (HP:0006561)2.84730329
24Abnormality of chromosome stability (HP:0003220)2.84397166
25Meckel diverticulum (HP:0002245)2.82602462
26Duodenal stenosis (HP:0100867)2.82132992
27Small intestinal stenosis (HP:0012848)2.82132992
28Abnormality of the ileum (HP:0001549)2.68159496
29Abnormality of the preputium (HP:0100587)2.63781936
30Abnormality of the duodenum (HP:0002246)2.54128529
31Short middle phalanx of the 5th finger (HP:0004220)2.51401907
32Increased serum lactate (HP:0002151)2.50054970
33Cerebral hypomyelination (HP:0006808)2.45007290
34Upper limb muscle weakness (HP:0003484)2.44822038
35Abnormality of homocysteine metabolism (HP:0010919)2.42345204
36Homocystinuria (HP:0002156)2.42345204
37Hyperinsulinemic hypoglycemia (HP:0000825)2.41085904
38Cortical visual impairment (HP:0100704)2.34727678
39Cerebral edema (HP:0002181)2.22193871
40Abnormality of alanine metabolism (HP:0010916)2.21911061
41Hyperalaninemia (HP:0003348)2.21911061
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21911061
43Sloping forehead (HP:0000340)2.21131497
44Horseshoe kidney (HP:0000085)2.15686697
45Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14378564
46Abnormal protein N-linked glycosylation (HP:0012347)2.14378564
47Abnormal protein glycosylation (HP:0012346)2.14378564
48Abnormal glycosylation (HP:0012345)2.14378564
49Type I transferrin isoform profile (HP:0003642)2.13808160
50Duplicated collecting system (HP:0000081)2.12618666
51Aplastic anemia (HP:0001915)2.08452892
52Pendular nystagmus (HP:0012043)2.07241016
53Pancreatic cysts (HP:0001737)2.04233008
54Lactic acidosis (HP:0003128)2.03060499
55Microvesicular hepatic steatosis (HP:0001414)2.02654205
56Amelogenesis imperfecta (HP:0000705)2.02571076
57Prominent metopic ridge (HP:0005487)2.00634402
58Abnormal lung lobation (HP:0002101)1.98726863
59Abnormality of serum amino acid levels (HP:0003112)1.98192056
60Respiratory failure (HP:0002878)1.94825013
61Pancytopenia (HP:0001876)1.93731076
62Small hand (HP:0200055)1.90915773
63CNS demyelination (HP:0007305)1.90146876
64Renal Fanconi syndrome (HP:0001994)1.90047406
65Abnormality of the renal collecting system (HP:0004742)1.89302921
66Hypothermia (HP:0002045)1.88931696
67Abnormal gallbladder physiology (HP:0012438)1.88020966
68Cholecystitis (HP:0001082)1.88020966
69Postnatal microcephaly (HP:0005484)1.85427458
70Hypsarrhythmia (HP:0002521)1.83196022
71Hyperglycinemia (HP:0002154)1.83097112
72Ependymoma (HP:0002888)1.82524462
73Abnormality of the carotid arteries (HP:0005344)1.82229641
74Abnormality of glycine metabolism (HP:0010895)1.80374422
75Abnormality of serine family amino acid metabolism (HP:0010894)1.80374422
76Methylmalonic acidemia (HP:0002912)1.77834279
77Overlapping toe (HP:0001845)1.77624710
78Delayed myelination (HP:0012448)1.74984599
79Abnormality of cochlea (HP:0000375)1.74852051
80Abnormality of the metopic suture (HP:0005556)1.72986770
81Type II lissencephaly (HP:0007260)1.72517423
82Exertional dyspnea (HP:0002875)1.72308961
83Megaloblastic anemia (HP:0001889)1.72033904
84Lethargy (HP:0001254)1.71691830
85Hypomagnesemia (HP:0002917)1.71542633
86Myelodysplasia (HP:0002863)1.71081792
87Abnormal hair whorl (HP:0010721)1.70645392
88Neoplasm of the adrenal gland (HP:0100631)1.70339457
89Hypoglycemic coma (HP:0001325)1.70327576
90EEG with generalized epileptiform discharges (HP:0011198)1.69498836
91Bone marrow hypocellularity (HP:0005528)1.68026277
92Muscular hypotonia of the trunk (HP:0008936)1.65231944
93Multiple enchondromatosis (HP:0005701)1.65103329
94Patellar aplasia (HP:0006443)1.65009115
95Absent thumb (HP:0009777)1.64870432
96Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.64692185
97Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.63992748
98Abnormality of DNA repair (HP:0003254)1.63354483
99Methylmalonic aciduria (HP:0012120)1.62745744
100Ectopic kidney (HP:0000086)1.62192349

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK63.76501063
2ZAK3.26434539
3BUB13.21619802
4MAP4K23.02833885
5TTK2.94202490
6EIF2AK32.72318860
7LATS12.60714553
8TRIM282.60151169
9MST42.50532572
10PLK42.43481910
11STK38L2.22424571
12EIF2AK12.20735356
13PLK32.15121582
14NME12.04224160
15SRPK12.02071034
16NEK11.99628432
17WNK31.93099884
18NUAK11.92423331
19MKNK21.90698603
20BMPR1B1.86179148
21FRK1.85976077
22CDC71.83722430
23TNIK1.61746521
24ACVR1B1.57433070
25BRSK21.54373690
26PDK21.51715351
27BCR1.46693482
28PINK11.45335255
29MKNK11.40216432
30WNK41.38195324
31ADRBK21.35559706
32PLK11.35213455
33MAP3K41.28192387
34WEE11.20848861
35CSNK1G21.20099512
36STK31.17550926
37CSNK1G11.16816978
38PBK1.15902342
39CSNK1G31.14820871
40DYRK21.11426823
41CSNK1A1L1.08302972
42ATR1.07341873
43PLK21.03449682
44GRK10.96786559
45PASK0.95625197
46OXSR10.94660815
47MAP2K70.93149947
48CHEK20.91920897
49LATS20.91267539
50NEK20.91191314
51ALK0.88487665
52CLK10.86466172
53STK160.85621930
54VRK10.85457651
55NLK0.85022544
56CCNB10.78729399
57VRK20.76939411
58BRSK10.76297397
59MAP3K120.74751210
60ATM0.72482949
61TLK10.71981189
62EIF2AK20.70304393
63STK390.69412701
64CHEK10.66727037
65MAP3K20.65693046
66TGFBR10.64711344
67BRAF0.62933775
68CSNK1E0.62785505
69AKT30.62001938
70ERBB30.61502519
71MAPK130.59687635
72INSRR0.56606814
73TAF10.54702770
74MINK10.54558245
75RPS6KA40.53564951
76CDK30.51914998
77BCKDK0.50848462
78PAK30.50617762
79PRKCG0.50560095
80CSNK2A20.48472818
81CSNK2A10.46364605
82RPS6KA50.46122977
83AURKB0.45347527
84DAPK10.44003388
85CSNK1A10.43792588
86MAP3K80.43291149
87STK40.42298651
88KSR20.41908238
89PRKCI0.40753117
90DAPK20.39145710
91FGFR20.39124073
92CDK10.39042796
93CDK20.38836696
94KSR10.36335883
95PHKG10.35901933
96PHKG20.35901933
97PIK3CG0.35468437
98STK380.33988506
99PRKDC0.32779899
100PRKCE0.32102918

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.84660758
2One carbon pool by folate_Homo sapiens_hsa006703.17838902
3Proteasome_Homo sapiens_hsa030503.05910174
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86924086
5Mismatch repair_Homo sapiens_hsa034302.85549088
6DNA replication_Homo sapiens_hsa030302.63409439
7Protein export_Homo sapiens_hsa030602.53357887
8Homologous recombination_Homo sapiens_hsa034402.37756656
9Non-homologous end-joining_Homo sapiens_hsa034502.27564850
10Steroid biosynthesis_Homo sapiens_hsa001002.16137699
11Basal transcription factors_Homo sapiens_hsa030222.15139354
12Fanconi anemia pathway_Homo sapiens_hsa034602.11704526
13RNA polymerase_Homo sapiens_hsa030202.11456303
14RNA transport_Homo sapiens_hsa030132.10295290
15Oxidative phosphorylation_Homo sapiens_hsa001902.04824606
16RNA degradation_Homo sapiens_hsa030181.91924319
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.90998520
18Selenocompound metabolism_Homo sapiens_hsa004501.88664877
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.87678515
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80138946
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68070850
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67027813
23Nucleotide excision repair_Homo sapiens_hsa034201.64399162
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64020677
25Phototransduction_Homo sapiens_hsa047441.63202085
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63017735
27Pyruvate metabolism_Homo sapiens_hsa006201.62718098
28Parkinsons disease_Homo sapiens_hsa050121.62630870
29Vitamin B6 metabolism_Homo sapiens_hsa007501.61517652
30Base excision repair_Homo sapiens_hsa034101.60775656
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.58558904
32Propanoate metabolism_Homo sapiens_hsa006401.54760578
33Spliceosome_Homo sapiens_hsa030401.54474494
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.34665154
35Butanoate metabolism_Homo sapiens_hsa006501.33061580
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32648604
37Cell cycle_Homo sapiens_hsa041101.30439845
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26937518
39Pyrimidine metabolism_Homo sapiens_hsa002401.26814950
40Biosynthesis of amino acids_Homo sapiens_hsa012301.24136732
41Collecting duct acid secretion_Homo sapiens_hsa049661.22014690
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20189990
43Huntingtons disease_Homo sapiens_hsa050161.14641584
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13203498
45Fatty acid elongation_Homo sapiens_hsa000621.08348758
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07710087
47Carbon metabolism_Homo sapiens_hsa012001.02921856
48Nicotine addiction_Homo sapiens_hsa050331.00201869
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99260046
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96206717
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95345704
52Purine metabolism_Homo sapiens_hsa002300.94854900
53Oocyte meiosis_Homo sapiens_hsa041140.87527846
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.84501586
55mRNA surveillance pathway_Homo sapiens_hsa030150.83188762
56Alzheimers disease_Homo sapiens_hsa050100.82486400
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76052287
58Metabolic pathways_Homo sapiens_hsa011000.75372903
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73196262
60N-Glycan biosynthesis_Homo sapiens_hsa005100.71001516
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70239941
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69843310
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67665876
64Fatty acid metabolism_Homo sapiens_hsa012120.67577234
65Vitamin digestion and absorption_Homo sapiens_hsa049770.66545008
66Folate biosynthesis_Homo sapiens_hsa007900.64900407
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63545709
68Glutathione metabolism_Homo sapiens_hsa004800.61430790
69Olfactory transduction_Homo sapiens_hsa047400.58229838
70beta-Alanine metabolism_Homo sapiens_hsa004100.55580296
71Tryptophan metabolism_Homo sapiens_hsa003800.53592641
72Arginine and proline metabolism_Homo sapiens_hsa003300.53242511
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51661393
74p53 signaling pathway_Homo sapiens_hsa041150.50739004
75Ether lipid metabolism_Homo sapiens_hsa005650.49000952
76Sulfur relay system_Homo sapiens_hsa041220.48682463
77Ribosome_Homo sapiens_hsa030100.47037338
78Peroxisome_Homo sapiens_hsa041460.46159079
79Taste transduction_Homo sapiens_hsa047420.45948354
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45248345
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41150065
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41066100
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40924805
84Sphingolipid metabolism_Homo sapiens_hsa006000.38609970
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37496979
86Synaptic vesicle cycle_Homo sapiens_hsa047210.36555738
87Vibrio cholerae infection_Homo sapiens_hsa051100.35241547
88Linoleic acid metabolism_Homo sapiens_hsa005910.34291687
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33208786
90Sulfur metabolism_Homo sapiens_hsa009200.31488051
91Nitrogen metabolism_Homo sapiens_hsa009100.30307095
92Fatty acid degradation_Homo sapiens_hsa000710.28287939
93Fat digestion and absorption_Homo sapiens_hsa049750.28275906
94Arginine biosynthesis_Homo sapiens_hsa002200.26534126
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25895635
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23785065
97GABAergic synapse_Homo sapiens_hsa047270.23678192
98Retinol metabolism_Homo sapiens_hsa008300.22801755
99Regulation of autophagy_Homo sapiens_hsa041400.19461990
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.19385370

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