ASNSP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to misfolded protein (GO:0051788)6.12826532
2RNA localization (GO:0006403)4.99023082
3mesenchymal cell differentiation involved in renal system development (GO:2001012)4.80708219
4mesenchymal cell differentiation involved in kidney development (GO:0072161)4.80708219
5regulation of DNA damage checkpoint (GO:2000001)4.64845591
6misfolded or incompletely synthesized protein catabolic process (GO:0006515)4.61514155
7water-soluble vitamin biosynthetic process (GO:0042364)4.30535193
8cell differentiation involved in metanephros development (GO:0072202)4.29957943
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.85672292
10antigen processing and presentation via MHC class Ib (GO:0002475)3.81527662
11protein neddylation (GO:0045116)3.79058495
12DNA replication checkpoint (GO:0000076)3.77880303
13nucleotide-excision repair, DNA gap filling (GO:0006297)3.77505579
14protein targeting to vacuole (GO:0006623)3.75288680
15protein targeting to lysosome (GO:0006622)3.75288680
16establishment of protein localization to vacuole (GO:0072666)3.75288680
17protein-cofactor linkage (GO:0018065)3.70049948
18iron-sulfur cluster assembly (GO:0016226)3.69881448
19metallo-sulfur cluster assembly (GO:0031163)3.69881448
20DNA strand renaturation (GO:0000733)3.69216736
21telomere maintenance via semi-conservative replication (GO:0032201)3.68722164
22nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.67901311
23positive regulation of embryonic development (GO:0040019)3.67768082
24pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.62959755
25UMP biosynthetic process (GO:0006222)3.62959755
26pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.62959755
27UMP metabolic process (GO:0046049)3.62959755
28regulation of hydrogen peroxide metabolic process (GO:0010310)3.54820834
29spermatid nucleus differentiation (GO:0007289)3.52769668
30exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.52493423
31adaptation of signaling pathway (GO:0023058)3.50666621
32positive regulation of T cell cytokine production (GO:0002726)3.50480825
33presynaptic membrane assembly (GO:0097105)3.47860194
34protein K11-linked ubiquitination (GO:0070979)3.44478034
35viral mRNA export from host cell nucleus (GO:0046784)3.44177049
36DNA ligation (GO:0006266)3.38420093
37nephron tubule morphogenesis (GO:0072078)3.32878580
38nephron epithelium morphogenesis (GO:0072088)3.32878580
39pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.31636362
40dopamine transport (GO:0015872)3.29686710
41oxidative demethylation (GO:0070989)3.27334155
42GMP metabolic process (GO:0046037)3.27123788
43GTP biosynthetic process (GO:0006183)3.27027258
44pyrimidine nucleobase catabolic process (GO:0006208)3.24654104
45ATP synthesis coupled proton transport (GO:0015986)3.20689798
46energy coupled proton transport, down electrochemical gradient (GO:0015985)3.20689798
47regulation of male gonad development (GO:2000018)3.20064434
48UTP biosynthetic process (GO:0006228)3.16277254
49translesion synthesis (GO:0019985)3.15154178
50pyrimidine ribonucleotide biosynthetic process (GO:0009220)3.14179402
51phospholipid scrambling (GO:0017121)3.05227515
52protein K11-linked deubiquitination (GO:0035871)3.04610287
53telomere maintenance via recombination (GO:0000722)3.03698738
54DNA double-strand break processing (GO:0000729)3.03592680
55regulation of skeletal muscle contraction (GO:0014819)3.02795577
56positive regulation of meiosis (GO:0045836)3.02325851
57DNA biosynthetic process (GO:0071897)3.01284014
58negative regulation of JUN kinase activity (GO:0043508)2.94370002
59epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92515511
60segment specification (GO:0007379)2.87745249
61transmission of nerve impulse (GO:0019226)2.87593325
62hindbrain development (GO:0030902)2.86551340
63regulation of glutamate secretion (GO:0014048)2.85149340
64regulation of glucocorticoid metabolic process (GO:0031943)2.83700314
65positive regulation of cellular response to oxidative stress (GO:1900409)2.82653675
66positive regulation of response to oxidative stress (GO:1902884)2.82653675
67positive regulation of meiotic cell cycle (GO:0051446)2.80650087
68pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.80262397
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.78241962
70CENP-A containing nucleosome assembly (GO:0034080)2.77997874
71DNA-dependent DNA replication (GO:0006261)2.76971977
72cornea development in camera-type eye (GO:0061303)2.75566566
73oocyte development (GO:0048599)2.74972656
74positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.72397204
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.71817898
76mitotic recombination (GO:0006312)2.71691777
77signal transduction involved in DNA integrity checkpoint (GO:0072401)2.70843603
78signal transduction involved in DNA damage checkpoint (GO:0072422)2.70843603
79regulation of double-strand break repair via homologous recombination (GO:0010569)2.70216226
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69677035
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69677035
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69677035
83signal transduction involved in cell cycle checkpoint (GO:0072395)2.69323301
84regulation of collateral sprouting (GO:0048670)2.68595175
85signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.68452432
86intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.68452432
87presynaptic membrane organization (GO:0097090)2.68197534
88regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.67720595
89regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.67720595
90negative regulation of hormone biosynthetic process (GO:0032353)2.67235515
91establishment of viral latency (GO:0019043)2.62297329
92nucleobase catabolic process (GO:0046113)2.62228388
93telomere maintenance via telomere lengthening (GO:0010833)2.62124620
94neuronal action potential propagation (GO:0019227)2.61304137
95regulation of oxidative phosphorylation (GO:0002082)2.61151760
96negative regulation of ligase activity (GO:0051352)2.61142483
97negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.61142483
98protein localization to lysosome (GO:0061462)2.61024661
99protein localization to vacuole (GO:0072665)2.61024661
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60941326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.88976361
2EZH2_22144423_ChIP-Seq_EOC_Human3.45431274
3IRF1_19129219_ChIP-ChIP_H3396_Human3.40408453
4GATA1_22025678_ChIP-Seq_K562_Human3.29347665
5FUS_26573619_Chip-Seq_HEK293_Human3.16150519
6EWS_26573619_Chip-Seq_HEK293_Human3.03647955
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.81873391
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.56462655
9AR_21572438_ChIP-Seq_LNCaP_Human2.54184659
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38483009
11IGF1R_20145208_ChIP-Seq_DFB_Human2.36246152
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.28101637
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.26504662
14PCGF2_27294783_Chip-Seq_NPCs_Mouse2.18642724
15DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.14755232
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.14603833
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99339266
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99046430
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.92887413
20FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.90346626
21TAF15_26573619_Chip-Seq_HEK293_Human1.87522804
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84712967
23GBX2_23144817_ChIP-Seq_PC3_Human1.84278388
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.81619910
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78026927
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69988487
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67422993
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.67131280
29P300_19829295_ChIP-Seq_ESCs_Human1.57945215
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57783350
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54812198
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52733451
33TP53_22573176_ChIP-Seq_HFKS_Human1.51134715
34BCAT_22108803_ChIP-Seq_LS180_Human1.50693905
35ER_23166858_ChIP-Seq_MCF-7_Human1.46969485
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45837842
37ZNF274_21170338_ChIP-Seq_K562_Hela1.45792935
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43378711
39ELK4_26923725_Chip-Seq_MESODERM_Mouse1.39211275
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35871022
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35683151
42RNF2_27304074_Chip-Seq_NSC_Mouse1.35498003
43RXR_22108803_ChIP-Seq_LS180_Human1.32514526
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.31442831
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.31246143
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27505145
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26922065
48OCT4_20526341_ChIP-Seq_ESCs_Human1.26757898
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26724633
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26613158
51NCOR_22424771_ChIP-Seq_293T_Human1.26396042
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.25295995
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22417549
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21874999
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21742556
56HTT_18923047_ChIP-ChIP_STHdh_Human1.21516007
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20305159
58CIITA_25753668_ChIP-Seq_RAJI_Human1.19179466
59P53_21459846_ChIP-Seq_SAOS-2_Human1.16661003
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.16551242
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14224822
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.14224822
63STAT3_23295773_ChIP-Seq_U87_Human1.13565386
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11466861
65CBP_20019798_ChIP-Seq_JUKART_Human1.11466861
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11407693
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.11051184
68VDR_23849224_ChIP-Seq_CD4+_Human1.09179403
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09117130
70E2F1_17053090_ChIP-ChIP_MCF-7_Human1.07244132
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06270891
72CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06040237
73ELK1_19687146_ChIP-ChIP_HELA_Human1.05867343
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.05664133
75AR_25329375_ChIP-Seq_VCAP_Human1.05090680
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04732951
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03535167
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01256336
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00543563
80RUNX2_22187159_ChIP-Seq_PCA_Human1.00427561
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99565548
82ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99064953
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99039197
84TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97983998
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97146600
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96190105
87SMAD4_21741376_ChIP-Seq_EPCs_Human0.94194947
88SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.94075312
89TAL1_26923725_Chip-Seq_HPCs_Mouse0.93312268
90EZH2_27294783_Chip-Seq_ESCs_Mouse0.92830245
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92550351
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92238990
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91992492
94SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91499875
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.91139523
96TCF4_22108803_ChIP-Seq_LS180_Human0.90828666
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.90813021
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90215701
99ERG_20517297_ChIP-Seq_VCAP_Human0.89459399
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88186936

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.88307150
2MP0002638_abnormal_pupillary_reflex3.67987109
3MP0000569_abnormal_digit_pigmentation3.66216778
4MP0003136_yellow_coat_color3.02936811
5MP0001529_abnormal_vocalization3.02719942
6MP0000751_myopathy2.94365833
7MP0005171_absent_coat_pigmentation2.85838511
8MP0006072_abnormal_retinal_apoptosis2.58136455
9MP0001968_abnormal_touch/_nociception2.48097498
10MP0001986_abnormal_taste_sensitivity2.36667366
11MP0008058_abnormal_DNA_repair2.30461170
12MP0002837_dystrophic_cardiac_calcinosis2.29371641
13MP0004885_abnormal_endolymph2.18324083
14MP0010386_abnormal_urinary_bladder2.18026095
15MP0008875_abnormal_xenobiotic_pharmacok2.13031848
16MP0004084_abnormal_cardiac_muscle1.97066303
17MP0002653_abnormal_ependyma_morphology1.95065621
18MP0005187_abnormal_penis_morphology1.89596573
19MP0005174_abnormal_tail_pigmentation1.88397019
20MP0000778_abnormal_nervous_system1.81559458
21MP0005423_abnormal_somatic_nervous1.80602801
22MP0003880_abnormal_central_pattern1.75158894
23MP0000631_abnormal_neuroendocrine_gland1.68515200
24MP0005551_abnormal_eye_electrophysiolog1.68293841
25MP0002909_abnormal_adrenal_gland1.67564673
26MP0005410_abnormal_fertilization1.66238291
27MP0002736_abnormal_nociception_after1.65119360
28MP0004215_abnormal_myocardial_fiber1.62434422
29MP0005253_abnormal_eye_physiology1.56968871
30MP0002938_white_spotting1.55558744
31MP0005377_hearing/vestibular/ear_phenot1.55222188
32MP0003878_abnormal_ear_physiology1.55222188
33MP0004272_abnormal_basement_membrane1.54033050
34MP0009780_abnormal_chondrocyte_physiolo1.51256157
35MP0002272_abnormal_nervous_system1.50391152
36MP0003936_abnormal_reproductive_system1.46459662
37MP0006276_abnormal_autonomic_nervous1.43884646
38MP0000013_abnormal_adipose_tissue1.43856758
39MP0002160_abnormal_reproductive_system1.36589639
40MP0000566_synostosis1.36321144
41MP0001293_anophthalmia1.36023742
42MP0000538_abnormal_urinary_bladder1.35635151
43MP0008872_abnormal_physiological_respon1.30990728
44MP0000026_abnormal_inner_ear1.23253601
45MP0001756_abnormal_urination1.19170639
46MP0009745_abnormal_behavioral_response1.19161701
47MP0003950_abnormal_plasma_membrane1.16890044
48MP0000750_abnormal_muscle_regeneration1.16267918
49MP0003315_abnormal_perineum_morphology1.07921954
50MP0002210_abnormal_sex_determination1.07769213
51MP0003121_genomic_imprinting1.04422269
52MP0005391_vision/eye_phenotype1.03103677
53MP0005503_abnormal_tendon_morphology1.03061212
54MP0004145_abnormal_muscle_electrophysio1.02677478
55MP0000653_abnormal_sex_gland1.00793135
56MP0004484_altered_response_of0.99094206
57MP0005248_abnormal_Harderian_gland0.98759455
58MP0002067_abnormal_sensory_capabilities0.96896041
59MP0001727_abnormal_embryo_implantation0.95387340
60MP0002876_abnormal_thyroid_physiology0.94953496
61MP0003183_abnormal_peptide_metabolism0.94765353
62MP0001963_abnormal_hearing_physiology0.94681380
63MP0000955_abnormal_spinal_cord0.93171409
64MP0001929_abnormal_gametogenesis0.92817459
65MP0003123_paternal_imprinting0.92394148
66MP0001879_abnormal_lymphatic_vessel0.89774682
67MP0003111_abnormal_nucleus_morphology0.89487775
68MP0005075_abnormal_melanosome_morpholog0.89390412
69MP0001145_abnormal_male_reproductive0.84120310
70MP0001486_abnormal_startle_reflex0.82654555
71MP0008995_early_reproductive_senescence0.82624884
72MP0005195_abnormal_posterior_eye0.81688651
73MP0001502_abnormal_circadian_rhythm0.81517848
74MP0003698_abnormal_male_reproductive0.81154653
75MP0004147_increased_porphyrin_level0.80905270
76MP0003755_abnormal_palate_morphology0.79647991
77MP0002734_abnormal_mechanical_nocicepti0.79564612
78MP0000747_muscle_weakness0.79025550
79MP0002752_abnormal_somatic_nervous0.78813959
80MP0003137_abnormal_impulse_conducting0.78756483
81MP0002697_abnormal_eye_size0.78474032
82MP0001970_abnormal_pain_threshold0.78260800
83MP0004142_abnormal_muscle_tone0.77248518
84MP0005389_reproductive_system_phenotype0.77240757
85MP0000647_abnormal_sebaceous_gland0.75872936
86MP0002184_abnormal_innervation0.75374942
87MP0004858_abnormal_nervous_system0.74901793
88MP0000537_abnormal_urethra_morphology0.71170546
89MP0000639_abnormal_adrenal_gland0.70540807
90MP0009046_muscle_twitch0.70111297
91MP0003938_abnormal_ear_development0.69825518
92MP0000049_abnormal_middle_ear0.69331195
93MP0000015_abnormal_ear_pigmentation0.69261471
94MP0002234_abnormal_pharynx_morphology0.68975129
95MP0001905_abnormal_dopamine_level0.68722981
96MP0005670_abnormal_white_adipose0.67441183
97MP0001501_abnormal_sleep_pattern0.64415568
98MP0001286_abnormal_eye_development0.63540640
99MP0001324_abnormal_eye_pigmentation0.63495522
100MP0000516_abnormal_urinary_system0.63493422

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)4.60112751
2Decreased activity of mitochondrial respiratory chain (HP:0008972)4.16981543
3Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.16981543
4Testicular atrophy (HP:0000029)3.79596816
5Esophageal atresia (HP:0002032)3.71522564
6Nephronophthisis (HP:0000090)3.43605412
7Fair hair (HP:0002286)3.43226440
8Hyperinsulinemic hypoglycemia (HP:0000825)3.42054468
9Abnormal sex determination (HP:0012244)3.41192459
10Sex reversal (HP:0012245)3.41192459
11J-shaped sella turcica (HP:0002680)3.35598471
12Hypoplasia of the ulna (HP:0003022)3.22402961
13Congenital stationary night blindness (HP:0007642)3.07505653
14Bony spicule pigmentary retinopathy (HP:0007737)3.00197513
153-Methylglutaconic aciduria (HP:0003535)2.99173928
16Facial diplegia (HP:0001349)2.97808066
17Abnormal rod and cone electroretinograms (HP:0008323)2.93734964
18Calf muscle hypertrophy (HP:0008981)2.90801037
19Aqueductal stenosis (HP:0002410)2.86614588
20Abnormality of the renal medulla (HP:0100957)2.85227349
21Choroideremia (HP:0001139)2.81570522
22True hermaphroditism (HP:0010459)2.72056014
23Scotoma (HP:0000575)2.71255851
24Spontaneous abortion (HP:0005268)2.70099077
25Cerebral palsy (HP:0100021)2.60200350
26Muscle hypertrophy of the lower extremities (HP:0008968)2.56488117
27Chronic hepatic failure (HP:0100626)2.56216365
28Aplasia/hypoplasia of the uterus (HP:0008684)2.54082666
29Rib fusion (HP:0000902)2.54063506
30Distal lower limb muscle weakness (HP:0009053)2.53495015
31Exertional dyspnea (HP:0002875)2.48808355
32Aplasia/Hypoplasia of the ulna (HP:0006495)2.44573935
33Pancreatic fibrosis (HP:0100732)2.42005751
34Pancreatic cysts (HP:0001737)2.41021086
35Attenuation of retinal blood vessels (HP:0007843)2.38170584
36Generalized hypopigmentation of hair (HP:0011358)2.34781615
37Hemivertebrae (HP:0002937)2.30997395
38Ulnar claw (HP:0001178)2.30455133
39Hypothermia (HP:0002045)2.29753391
40Abnormality of the calf musculature (HP:0001430)2.29528216
41Abnormal mitochondria in muscle tissue (HP:0008316)2.22272224
42Joint hemorrhage (HP:0005261)2.21386188
43Focal motor seizures (HP:0011153)2.21331200
44Round ear (HP:0100830)2.21122534
45Acute necrotizing encephalopathy (HP:0006965)2.20135774
46Abnormal number of erythroid precursors (HP:0012131)2.19007815
47Medial flaring of the eyebrow (HP:0010747)2.18485572
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15988218
49Abnormality of alanine metabolism (HP:0010916)2.15988218
50Hyperalaninemia (HP:0003348)2.15988218
51Deformed sella turcica (HP:0002681)2.15875337
52Abnormal respiratory epithelium morphology (HP:0012253)2.13582151
53Abnormal respiratory motile cilium morphology (HP:0005938)2.13582151
54Increased intramyocellular lipid droplets (HP:0012240)2.13015973
55Myotonia (HP:0002486)2.12619431
56Aplasia cutis congenita (HP:0001057)2.12177011
57Gastrointestinal atresia (HP:0002589)2.10180746
58Abnormality of the parathyroid morphology (HP:0011766)2.08595874
59Oligodactyly (HP:0012165)2.07373124
60Abnormality of dental color (HP:0011073)2.05935625
61Oligodactyly (hands) (HP:0001180)2.05847947
62Type II lissencephaly (HP:0007260)2.05765513
63Ankle clonus (HP:0011448)2.05075021
64Forearm undergrowth (HP:0009821)2.04851585
65Mitral stenosis (HP:0001718)2.02363360
66Abnormality of the fovea (HP:0000493)2.02342477
67Hyperventilation (HP:0002883)2.01915078
68Aplasia/Hypoplasia of the patella (HP:0006498)1.98483858
69Intestinal atresia (HP:0011100)1.98077157
70Chronic sinusitis (HP:0011109)1.97652966
71Progressive macrocephaly (HP:0004481)1.94750543
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91068081
73Aplasia/Hypoplasia of the tongue (HP:0010295)1.90618579
74External ophthalmoplegia (HP:0000544)1.90018943
75Exotropia (HP:0000577)1.88045378
76Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.87466743
77Abnormality of incisor morphology (HP:0011063)1.86731162
78Renovascular hypertension (HP:0100817)1.86593880
79Abnormality of the diencephalon (HP:0010662)1.85506895
80Molar tooth sign on MRI (HP:0002419)1.84008519
81Abnormality of midbrain morphology (HP:0002418)1.84008519
82Patellar aplasia (HP:0006443)1.81610561
83Hyporeflexia of lower limbs (HP:0002600)1.81475231
84Abnormal biliary tract physiology (HP:0012439)1.81006010
85Bile duct proliferation (HP:0001408)1.81006010
86Elfin facies (HP:0004428)1.80780043
87Synostosis involving the elbow (HP:0003938)1.80050609
88Humeroradial synostosis (HP:0003041)1.80050609
89Abnormal ciliary motility (HP:0012262)1.79779735
90Generalized aminoaciduria (HP:0002909)1.79055364
91Abnormality of cells of the erythroid lineage (HP:0012130)1.78517963
92Acute encephalopathy (HP:0006846)1.76716945
93Craniofacial dystonia (HP:0012179)1.76699050
94Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76281230
95Progressive microcephaly (HP:0000253)1.75502323
96Gowers sign (HP:0003391)1.75001153
97Abnormality of the phalanges of the 2nd finger (HP:0009541)1.72980070
98Congenital malformation of the right heart (HP:0011723)1.72806649
99Double outlet right ventricle (HP:0001719)1.72806649
100Occipital encephalocele (HP:0002085)1.72313843

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.66020305
2CCNB13.59418296
3BLK3.43753177
4EPHB22.84490412
5TLK12.64179595
6ERBB32.48766315
7EPHA42.43355853
8MKNK12.27845565
9MAPK152.24872295
10FRK2.24615262
11MKNK22.12968441
12PLK22.02751561
13WNK11.84967753
14MARK11.79824379
15PLK41.72042356
16SRPK11.69134810
17STK161.59715409
18GRK51.59684376
19WNK31.54981954
20WNK41.48129376
21VRK21.47573412
22ZAK1.47319304
23BMPR1B1.44737457
24CDK31.40633441
25MYLK1.31376659
26INSRR1.30937960
27PLK11.25627646
28LIMK11.24994558
29MUSK1.23535242
30TGFBR11.22299986
31BRSK21.17955244
32OBSCN1.13360530
33EPHA31.12492277
34GRK11.07910954
35MAP4K21.07649037
36MAP3K41.05891412
37DYRK1B1.05595338
38CSNK1G11.03875778
39DYRK21.03866734
40ADRBK21.01454635
41CSNK1G31.01298371
42DYRK1A0.94075904
43PLK30.93729582
44WEE10.90942366
45CSNK1A1L0.90499965
46FER0.90242890
47TRIM280.87209019
48CAMK2D0.84764625
49TIE10.79847157
50CSNK1A10.79334295
51MAPK70.78980620
52TNK20.78450283
53PKN20.74182837
54GRK70.73102693
55DAPK20.72832745
56PHKG10.72804812
57PHKG20.72804812
58NUAK10.72358906
59PASK0.72010791
60PRKD20.70647232
61PRKCE0.69173801
62AURKA0.68965874
63MARK20.68411267
64ADRBK10.68183540
65TESK20.67947926
66VRK10.65742253
67TRIB30.63421472
68CDK70.61047742
69CSNK1G20.60933833
70PKN10.59774274
71TAOK10.58904537
72PRKACB0.58004219
73MAP2K70.57892526
74TAOK30.54335497
75PIK3CA0.54129946
76PRKACA0.53874436
77PDK20.52679573
78PRKD30.49893301
79PAK30.49863769
80NEK60.48630344
81PRKACG0.47760535
82NLK0.47448963
83SIK20.46743319
84NTRK20.46195100
85NME10.45774387
86PTK60.43784975
87CHEK20.43632584
88PRKD10.43599493
89PRKCA0.43513598
90GRK60.43325622
91PRKG10.43103780
92CDK80.42990791
93TTK0.42140803
94CDK60.41851113
95SYK0.41675840
96BRSK10.41220930
97PRKAA10.40362783
98CDK11A0.40042184
99AURKB0.39091128
100INSR0.38975124

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.99802445
2Phototransduction_Homo sapiens_hsa047443.40437579
3Homologous recombination_Homo sapiens_hsa034403.03148238
4DNA replication_Homo sapiens_hsa030302.88216649
5Mismatch repair_Homo sapiens_hsa034302.70190326
6Asthma_Homo sapiens_hsa053102.57021642
7Nitrogen metabolism_Homo sapiens_hsa009102.53698007
8Oxidative phosphorylation_Homo sapiens_hsa001902.51354294
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.36698606
10Ribosome_Homo sapiens_hsa030102.06246150
11Fanconi anemia pathway_Homo sapiens_hsa034602.04137236
12RNA degradation_Homo sapiens_hsa030181.84390745
13Nicotine addiction_Homo sapiens_hsa050331.83726812
14Parkinsons disease_Homo sapiens_hsa050121.79753237
15Cardiac muscle contraction_Homo sapiens_hsa042601.74458382
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.74384341
17Autoimmune thyroid disease_Homo sapiens_hsa053201.70564887
18Nucleotide excision repair_Homo sapiens_hsa034201.63323128
19RNA polymerase_Homo sapiens_hsa030201.61474550
20Non-homologous end-joining_Homo sapiens_hsa034501.61275189
21Linoleic acid metabolism_Homo sapiens_hsa005911.54059255
22Staphylococcus aureus infection_Homo sapiens_hsa051501.53610846
23Allograft rejection_Homo sapiens_hsa053301.47426621
24Pyrimidine metabolism_Homo sapiens_hsa002401.47235851
25Hedgehog signaling pathway_Homo sapiens_hsa043401.47113439
26Basal cell carcinoma_Homo sapiens_hsa052171.46360613
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42468268
28Basal transcription factors_Homo sapiens_hsa030221.34279871
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.33386297
30Graft-versus-host disease_Homo sapiens_hsa053321.31363962
31ABC transporters_Homo sapiens_hsa020101.28577202
32Collecting duct acid secretion_Homo sapiens_hsa049661.27527135
33Huntingtons disease_Homo sapiens_hsa050161.27185856
34Base excision repair_Homo sapiens_hsa034101.20508348
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15261822
36Taste transduction_Homo sapiens_hsa047421.10881920
37Type I diabetes mellitus_Homo sapiens_hsa049401.09366610
38Arachidonic acid metabolism_Homo sapiens_hsa005901.05304151
39Caffeine metabolism_Homo sapiens_hsa002321.05011471
40Sphingolipid metabolism_Homo sapiens_hsa006001.02687493
41GABAergic synapse_Homo sapiens_hsa047271.00671639
42Alzheimers disease_Homo sapiens_hsa050100.97113617
43Dilated cardiomyopathy_Homo sapiens_hsa054140.96001628
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95995787
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.95660710
46Spliceosome_Homo sapiens_hsa030400.93100539
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.92355863
48Rheumatoid arthritis_Homo sapiens_hsa053230.90781231
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90678652
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90543893
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89216014
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88054584
53Tryptophan metabolism_Homo sapiens_hsa003800.87987339
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85953661
55Purine metabolism_Homo sapiens_hsa002300.83852119
56Morphine addiction_Homo sapiens_hsa050320.76958744
57Viral myocarditis_Homo sapiens_hsa054160.76549332
58Arginine biosynthesis_Homo sapiens_hsa002200.76485593
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76478673
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72131384
61Insulin secretion_Homo sapiens_hsa049110.70289302
62Chemical carcinogenesis_Homo sapiens_hsa052040.69141954
63mRNA surveillance pathway_Homo sapiens_hsa030150.68789321
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68122322
65Ovarian steroidogenesis_Homo sapiens_hsa049130.67637764
66Oocyte meiosis_Homo sapiens_hsa041140.63943903
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63038660
68Antigen processing and presentation_Homo sapiens_hsa046120.62838167
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59901151
70Leishmaniasis_Homo sapiens_hsa051400.58625330
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56767448
72Thyroid hormone synthesis_Homo sapiens_hsa049180.56302758
73Hippo signaling pathway_Homo sapiens_hsa043900.52443948
74Systemic lupus erythematosus_Homo sapiens_hsa053220.51488286
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48826966
76Axon guidance_Homo sapiens_hsa043600.48826717
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48011402
78Olfactory transduction_Homo sapiens_hsa047400.47913832
79Fatty acid elongation_Homo sapiens_hsa000620.47893666
80Glutamatergic synapse_Homo sapiens_hsa047240.47622801
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47292764
82Retinol metabolism_Homo sapiens_hsa008300.45402667
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43831075
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42849557
85Sulfur relay system_Homo sapiens_hsa041220.42648470
86Metabolic pathways_Homo sapiens_hsa011000.41944544
87Melanogenesis_Homo sapiens_hsa049160.40989036
88Regulation of autophagy_Homo sapiens_hsa041400.39302474
89Glutathione metabolism_Homo sapiens_hsa004800.38984790
90Calcium signaling pathway_Homo sapiens_hsa040200.36620395
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35124522
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34294345
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34248598
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33704049
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32497401
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31776665
97Cell cycle_Homo sapiens_hsa041100.31688940
98Cholinergic synapse_Homo sapiens_hsa047250.31494686
99Phagosome_Homo sapiens_hsa041450.30391082
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26570245

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