ASNSP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of feeding behavior (GO:0060259)7.85886544
2adult feeding behavior (GO:0008343)6.58232991
3viral transcription (GO:0019083)6.43148380
4translational termination (GO:0006415)6.21992626
5chaperone-mediated protein transport (GO:0072321)6.07490679
6establishment of protein localization to mitochondrial membrane (GO:0090151)5.34292342
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.29937127
8cotranslational protein targeting to membrane (GO:0006613)5.25853932
9translational elongation (GO:0006414)5.21344018
10protein targeting to ER (GO:0045047)5.20681541
11regulation of secondary heart field cardioblast proliferation (GO:0003266)5.08882812
12regulation of cardioblast proliferation (GO:0003264)5.08882812
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.97947598
14behavioral response to nicotine (GO:0035095)4.94422624
15protein localization to endoplasmic reticulum (GO:0070972)4.90953619
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.83215157
17cellular protein complex disassembly (GO:0043624)4.73746592
18viral life cycle (GO:0019058)4.72519801
19ribosomal small subunit biogenesis (GO:0042274)4.70362415
20pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.65994727
21ATP synthesis coupled proton transport (GO:0015986)4.64431642
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.64431642
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.61026490
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.51619752
25ribosomal small subunit assembly (GO:0000028)4.23514925
26respiratory electron transport chain (GO:0022904)4.16647117
27electron transport chain (GO:0022900)4.14859462
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.14431084
29mitochondrial respiratory chain complex I assembly (GO:0032981)4.14431084
30NADH dehydrogenase complex assembly (GO:0010257)4.14431084
31translational initiation (GO:0006413)4.12661665
32protein complex disassembly (GO:0043241)4.09695176
33sequestering of actin monomers (GO:0042989)4.01722045
34maturation of SSU-rRNA (GO:0030490)4.00014392
35protein neddylation (GO:0045116)3.97677959
36cellular protein complex localization (GO:0034629)3.94344378
37macromolecular complex disassembly (GO:0032984)3.93728129
38protein complex biogenesis (GO:0070271)3.92741714
39pyrimidine nucleotide catabolic process (GO:0006244)3.87560205
40protein polyglutamylation (GO:0018095)3.77771821
41ribosomal large subunit biogenesis (GO:0042273)3.55256735
42mitochondrial respiratory chain complex assembly (GO:0033108)3.52837901
43translation (GO:0006412)3.52244878
44negative regulation of appetite (GO:0032099)3.51386191
45negative regulation of response to food (GO:0032096)3.51386191
46protein targeting to membrane (GO:0006612)3.49813381
47pyrimidine nucleobase catabolic process (GO:0006208)3.46430723
48retinal ganglion cell axon guidance (GO:0031290)3.45427933
49cardiac right ventricle morphogenesis (GO:0003215)3.43654942
50base-excision repair, AP site formation (GO:0006285)3.37639438
51muscle organ morphogenesis (GO:0048644)3.35615695
52tachykinin receptor signaling pathway (GO:0007217)3.31002033
53outer ear morphogenesis (GO:0042473)3.30579903
54opioid receptor signaling pathway (GO:0038003)3.27385240
55outflow tract septum morphogenesis (GO:0003148)3.26897114
56spinal cord motor neuron differentiation (GO:0021522)3.22596218
57negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.22276696
58transmission of nerve impulse (GO:0019226)3.20562766
59regulation of action potential (GO:0098900)3.19572044
60tooth mineralization (GO:0034505)3.16864427
61cell differentiation in spinal cord (GO:0021515)3.14695574
62nuclear-transcribed mRNA catabolic process (GO:0000956)3.10227735
63regulation of dopamine metabolic process (GO:0042053)3.08142031
64regulation of catecholamine metabolic process (GO:0042069)3.08142031
65atrial septum morphogenesis (GO:0060413)3.04803171
66RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04411959
67tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04411959
68protein localization to cilium (GO:0061512)3.04361409
69gamma-aminobutyric acid transport (GO:0015812)3.03515154
70negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.99380440
71hydrogen ion transmembrane transport (GO:1902600)2.96720619
72regulation of cilium movement (GO:0003352)2.96088422
73inner mitochondrial membrane organization (GO:0007007)2.95944784
74secondary heart field specification (GO:0003139)2.95148049
75heart field specification (GO:0003128)2.95148049
76neural tube formation (GO:0001841)2.94911612
77somite development (GO:0061053)2.94620052
78cardiovascular system development (GO:0072358)2.92130934
79mRNA catabolic process (GO:0006402)2.88964381
80protein-cofactor linkage (GO:0018065)2.88368195
81neuron fate specification (GO:0048665)2.86290319
82GPI anchor metabolic process (GO:0006505)2.86204584
83ventricular system development (GO:0021591)2.85323579
84limb development (GO:0060173)2.85232677
85appendage development (GO:0048736)2.85232677
86cranial nerve development (GO:0021545)2.84090713
87cellular component biogenesis (GO:0044085)2.81930664
88positive regulation of action potential (GO:0045760)2.80716296
89intracellular protein transmembrane import (GO:0044743)2.76524915
90GTP biosynthetic process (GO:0006183)2.75251534
91nucleobase catabolic process (GO:0046113)2.74170509
92spinal cord development (GO:0021510)2.73484711
93regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.72287146
94regulation of microtubule-based movement (GO:0060632)2.71548823
95regulation of mesenchymal cell apoptotic process (GO:2001053)2.68746292
96organelle disassembly (GO:1903008)2.67848818
97epithelial cilium movement (GO:0003351)2.67407842
98regulation of appetite (GO:0032098)2.64541527
99striatum development (GO:0021756)2.64323714
100proton transport (GO:0015992)2.61531450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.22952856
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.41537166
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.37297807
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.03800989
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.91876526
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.90908147
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85877929
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.74022881
9FUS_26573619_Chip-Seq_HEK293_Human2.67401263
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.60565642
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.59078786
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.57420107
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.55847816
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.37224046
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35876512
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25461454
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24965239
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.10198708
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08779860
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08237501
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.05165355
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.02807821
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.96218868
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95215292
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.85828130
26RNF2_27304074_Chip-Seq_NSC_Mouse1.83511716
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.82752619
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73398972
29ZNF274_21170338_ChIP-Seq_K562_Hela1.73127380
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72992164
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72180481
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70754160
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.65748088
34VDR_23849224_ChIP-Seq_CD4+_Human1.63455864
35REST_21632747_ChIP-Seq_MESCs_Mouse1.62963989
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61300184
37XRN2_22483619_ChIP-Seq_HELA_Human1.59973815
38GBX2_23144817_ChIP-Seq_PC3_Human1.52501486
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.50579676
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.50579676
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49711793
42IRF1_19129219_ChIP-ChIP_H3396_Human1.48909894
43TP53_20018659_ChIP-ChIP_R1E_Mouse1.47375470
44GABP_19822575_ChIP-Seq_HepG2_Human1.47366843
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45882407
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45097969
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43414415
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42703789
49VDR_22108803_ChIP-Seq_LS180_Human1.42279541
50TTF2_22483619_ChIP-Seq_HELA_Human1.35339943
51SOX2_16153702_ChIP-ChIP_HESCs_Human1.35075129
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34328715
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31521791
54FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30548827
55SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28961242
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27420800
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27109802
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.24033778
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22027816
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18176257
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.16015764
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15432050
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14923092
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13538427
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12953441
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.09127784
67TP53_22573176_ChIP-Seq_HFKS_Human1.07675233
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.06652791
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06281079
70FOXP3_21729870_ChIP-Seq_TREG_Human1.06120558
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.05674559
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05276579
73DCP1A_22483619_ChIP-Seq_HELA_Human1.03988021
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01759161
75MYC_18940864_ChIP-ChIP_HL60_Human1.00572880
76EWS_26573619_Chip-Seq_HEK293_Human0.98043440
77TAF15_26573619_Chip-Seq_HEK293_Human0.95167819
78NANOG_16153702_ChIP-ChIP_HESCs_Human0.93743636
79CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92525324
80ELK1_19687146_ChIP-ChIP_HELA_Human0.90686756
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90125436
82PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90095175
83MYC_19030024_ChIP-ChIP_MESCs_Mouse0.89825019
84FOXP1_21924763_ChIP-Seq_HESCs_Human0.89006340
85RING1B_27294783_Chip-Seq_ESCs_Mouse0.88456594
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88446942
87SRF_21415370_ChIP-Seq_HL-1_Mouse0.88432918
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87302774
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87138951
90P300_19829295_ChIP-Seq_ESCs_Human0.86852464
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86618059
92FLI1_27457419_Chip-Seq_LIVER_Mouse0.85279712
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85114977
94ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84502641
95MTF2_20144788_ChIP-Seq_MESCs_Mouse0.84329151
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.82503770
97REST_19997604_ChIP-ChIP_NEURONS_Mouse0.76076918
98SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75826683
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.75797222
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.75645074

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.06919468
2MP0009379_abnormal_foot_pigmentation3.86526814
3MP0003880_abnormal_central_pattern3.05548656
4MP0001661_extended_life_span3.03342742
5MP0005394_taste/olfaction_phenotype2.88407558
6MP0005499_abnormal_olfactory_system2.88407558
7MP0003122_maternal_imprinting2.55350432
8MP0008789_abnormal_olfactory_epithelium2.53240778
9MP0006072_abnormal_retinal_apoptosis2.38541160
10MP0010030_abnormal_orbit_morphology2.27468321
11MP0006276_abnormal_autonomic_nervous2.27341444
12MP0001529_abnormal_vocalization2.26815040
13MP0004142_abnormal_muscle_tone2.22274635
14MP0002234_abnormal_pharynx_morphology2.19564512
15MP0000569_abnormal_digit_pigmentation2.06845480
16MP0002822_catalepsy2.06379772
17MP0003890_abnormal_embryonic-extraembry2.02502089
18MP0003806_abnormal_nucleotide_metabolis1.92366280
19MP0000631_abnormal_neuroendocrine_gland1.90912812
20MP0002249_abnormal_larynx_morphology1.87982507
21MP0000566_synostosis1.84705700
22MP0000778_abnormal_nervous_system1.84641497
23MP0005423_abnormal_somatic_nervous1.84133216
24MP0002277_abnormal_respiratory_mucosa1.83083863
25MP0001293_anophthalmia1.82627917
26MP0005646_abnormal_pituitary_gland1.80575059
27MP0003121_genomic_imprinting1.79272312
28MP0002160_abnormal_reproductive_system1.72589374
29MP0000049_abnormal_middle_ear1.67100267
30MP0001905_abnormal_dopamine_level1.50019363
31MP0004133_heterotaxia1.46917795
32MP0004885_abnormal_endolymph1.44222300
33MP0010386_abnormal_urinary_bladder1.40729239
34MP0000534_abnormal_ureter_morphology1.36880851
35MP0005253_abnormal_eye_physiology1.35568166
36MP0009745_abnormal_behavioral_response1.35518303
37MP0001968_abnormal_touch/_nociception1.32272054
38MP0005389_reproductive_system_phenotype1.29408524
39MP0002736_abnormal_nociception_after1.26538837
40MP0003123_paternal_imprinting1.26207528
41MP0005377_hearing/vestibular/ear_phenot1.25613457
42MP0003878_abnormal_ear_physiology1.25613457
43MP0001188_hyperpigmentation1.23517331
44MP0000678_abnormal_parathyroid_gland1.22785219
45MP0004742_abnormal_vestibular_system1.22597684
46MP0001440_abnormal_grooming_behavior1.22367557
47MP0002184_abnormal_innervation1.21267198
48MP0005551_abnormal_eye_electrophysiolog1.20417941
49MP0003635_abnormal_synaptic_transmissio1.19686903
50MP0001346_abnormal_lacrimal_gland1.19469388
51MP0003959_abnormal_lean_body1.18490909
52MP0003938_abnormal_ear_development1.18490100
53MP0002282_abnormal_trachea_morphology1.17450160
54MP0002697_abnormal_eye_size1.14603091
55MP0003136_yellow_coat_color1.14372864
56MP0000372_irregular_coat_pigmentation1.12608201
57MP0005195_abnormal_posterior_eye1.12141801
58MP0001984_abnormal_olfaction1.10171411
59MP0000026_abnormal_inner_ear1.10146217
60MP0002734_abnormal_mechanical_nocicepti1.09076856
61MP0008995_early_reproductive_senescence1.07739427
62MP0002837_dystrophic_cardiac_calcinosis1.07406768
63MP0002272_abnormal_nervous_system1.06291878
64MP0005187_abnormal_penis_morphology1.05865129
65MP0002067_abnormal_sensory_capabilities1.05043405
66MP0002928_abnormal_bile_duct1.04424125
67MP0002572_abnormal_emotion/affect_behav1.04413244
68MP0004145_abnormal_muscle_electrophysio1.04233434
69MP0002735_abnormal_chemical_nociception1.01888914
70MP0002653_abnormal_ependyma_morphology1.01173711
71MP0000955_abnormal_spinal_cord1.00945306
72MP0004811_abnormal_neuron_physiology1.00403599
73MP0009046_muscle_twitch1.00275389
74MP0004270_analgesia1.00194896
75MP0002233_abnormal_nose_morphology0.99531021
76MP0001286_abnormal_eye_development0.99014764
77MP0005391_vision/eye_phenotype0.98150065
78MP0001485_abnormal_pinna_reflex0.97601878
79MP0003011_delayed_dark_adaptation0.96824783
80MP0001970_abnormal_pain_threshold0.96262090
81MP0002938_white_spotting0.94426024
82MP0002638_abnormal_pupillary_reflex0.94212405
83MP0005084_abnormal_gallbladder_morpholo0.93615291
84MP0008875_abnormal_xenobiotic_pharmacok0.93062277
85MP0001919_abnormal_reproductive_system0.92925294
86MP0002064_seizures0.92785024
87MP0005248_abnormal_Harderian_gland0.92780246
88MP0003942_abnormal_urinary_system0.91908934
89MP0002063_abnormal_learning/memory/cond0.91772334
90MP0002752_abnormal_somatic_nervous0.90850362
91MP0002882_abnormal_neuron_morphology0.90663915
92MP0001963_abnormal_hearing_physiology0.85290652
93MP0002751_abnormal_autonomic_nervous0.84723069
94MP0003137_abnormal_impulse_conducting0.82602844
95MP0008877_abnormal_DNA_methylation0.81647493
96MP0002557_abnormal_social/conspecific_i0.80476440
97MP0001324_abnormal_eye_pigmentation0.79151151
98MP0005670_abnormal_white_adipose0.79108254
99MP0006035_abnormal_mitochondrial_morpho0.78312005
100MP0001879_abnormal_lymphatic_vessel0.75870171

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.71253854
2Renal Fanconi syndrome (HP:0001994)4.66020447
3Increased hepatocellular lipid droplets (HP:0006565)4.42610999
4Lipid accumulation in hepatocytes (HP:0006561)4.33947960
5Abnormal mitochondria in muscle tissue (HP:0008316)4.24949339
6Mitochondrial inheritance (HP:0001427)4.03192064
7Progressive macrocephaly (HP:0004481)3.79914836
8Acute encephalopathy (HP:0006846)3.74021464
9Abnormality of cells of the erythroid lineage (HP:0012130)3.65697602
10Humeroradial synostosis (HP:0003041)3.61778849
11Synostosis involving the elbow (HP:0003938)3.61778849
12Abnormal number of erythroid precursors (HP:0012131)3.38973319
13Increased CSF lactate (HP:0002490)3.37677069
14Increased intramyocellular lipid droplets (HP:0012240)3.27348306
15Abnormality of renal resorption (HP:0011038)3.23976780
16Molar tooth sign on MRI (HP:0002419)3.14306958
17Abnormality of midbrain morphology (HP:0002418)3.14306958
18Increased muscle lipid content (HP:0009058)2.97557023
19Macrocytic anemia (HP:0001972)2.91159455
20Absent rod-and cone-mediated responses on ERG (HP:0007688)2.88624184
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.88541777
22Cerebral edema (HP:0002181)2.77628634
23Abnormality of the phalanges of the 2nd finger (HP:0009541)2.74205775
24Nephronophthisis (HP:0000090)2.73378142
25Hepatocellular necrosis (HP:0001404)2.68992362
26Optic disc pallor (HP:0000543)2.68864108
27Gait imbalance (HP:0002141)2.65969581
28Medial flaring of the eyebrow (HP:0010747)2.55733527
29Testicular atrophy (HP:0000029)2.51386681
30Exertional dyspnea (HP:0002875)2.48327670
31Symphalangism affecting the phalanges of the hand (HP:0009773)2.46553694
32Cortical dysplasia (HP:0002539)2.46312848
33Myokymia (HP:0002411)2.46221046
34Abnormality of the aortic arch (HP:0012303)2.39343671
35Abnormality of urine glucose concentration (HP:0011016)2.34749855
36Glycosuria (HP:0003076)2.34749855
37Septo-optic dysplasia (HP:0100842)2.34374924
38Congenital primary aphakia (HP:0007707)2.31805514
39Abnormality of the labia minora (HP:0012880)2.30674897
40Optic nerve coloboma (HP:0000588)2.30504737
41Leukodystrophy (HP:0002415)2.29437318
42Abnormality of the anterior horn cell (HP:0006802)2.29060179
43Degeneration of anterior horn cells (HP:0002398)2.29060179
44Increased serum lactate (HP:0002151)2.27489869
45Lissencephaly (HP:0001339)2.26230019
46Reticulocytopenia (HP:0001896)2.25963659
47Abnormal rod and cone electroretinograms (HP:0008323)2.25461126
48Adactyly (HP:0009776)2.24172530
49Abnormality of the 4th metacarpal (HP:0010012)2.23449179
50Deformed tarsal bones (HP:0008119)2.20987277
51Abnormality of the renal medulla (HP:0100957)2.20549308
52Abnormality of the middle phalanges of the toes (HP:0010183)2.20258062
53Congenital malformation of the right heart (HP:0011723)2.19161964
54Double outlet right ventricle (HP:0001719)2.19161964
55Exercise intolerance (HP:0003546)2.16711658
56Hepatic necrosis (HP:0002605)2.15096967
57Hypoplasia of the pons (HP:0012110)2.14033501
58Pancreatic cysts (HP:0001737)2.09188774
59Polyphagia (HP:0002591)2.08274841
60Pallor (HP:0000980)2.07682705
61Generalized aminoaciduria (HP:0002909)2.06968927
62Fibular hypoplasia (HP:0003038)2.06551167
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.06550512
64Lactic acidosis (HP:0003128)2.04058469
65Limb dystonia (HP:0002451)2.03619812
66Nephrogenic diabetes insipidus (HP:0009806)2.02348249
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.01249751
68Short 4th metacarpal (HP:0010044)2.01249751
69Abnormality of the parietal bone (HP:0002696)2.01209492
70Short phalanx of the thumb (HP:0009660)1.97188982
71Stenosis of the external auditory canal (HP:0000402)1.95270432
72Abnormality of the pons (HP:0007361)1.94204023
73Short tibia (HP:0005736)1.93545415
74Failure to thrive in infancy (HP:0001531)1.92713713
75Sclerocornea (HP:0000647)1.91125635
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.90624177
77Anencephaly (HP:0002323)1.89665191
78Aplasia/Hypoplasia of the tibia (HP:0005772)1.89570472
79Respiratory difficulties (HP:0002880)1.89370883
80Specific learning disability (HP:0001328)1.89252051
81Hypoplasia of the radius (HP:0002984)1.88558715
82Broad-based gait (HP:0002136)1.87313042
83Decreased muscle mass (HP:0003199)1.86290260
84Hyperphosphaturia (HP:0003109)1.86139703
85Aplasia/Hypoplasia of the patella (HP:0006498)1.85640800
86Polydipsia (HP:0001959)1.83531062
87Abnormal drinking behavior (HP:0030082)1.83531062
88Overriding aorta (HP:0002623)1.80978960
89Down-sloping shoulders (HP:0200021)1.80946204
90Abnormality of the lower motor neuron (HP:0002366)1.79582265
91Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.79126807
92Partial duplication of thumb phalanx (HP:0009944)1.78733651
93Aplastic anemia (HP:0001915)1.78719535
94True hermaphroditism (HP:0010459)1.78714970
95Pancreatic fibrosis (HP:0100732)1.76142831
96Depressed nasal ridge (HP:0000457)1.76058206
97Vaginal atresia (HP:0000148)1.75437445
98Bulbous nose (HP:0000414)1.74313470
99Sleep apnea (HP:0010535)1.73879752
100Abnormal connection of the cardiac segments (HP:0011545)1.72798872

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.26060309
2MAP3K113.27453695
3WNK33.17359829
4PNCK3.01548822
5TLK12.97662021
6MARK12.96008210
7MAP3K122.67118919
8DYRK22.64903837
9GRK72.41099924
10TNIK2.35842259
11CDK192.27696333
12WNK42.20285164
13OXSR12.16732653
14NME22.14761632
15LIMK12.10043461
16MAP2K42.03182446
17BMPR1B2.01506142
18MAP2K71.94286281
19TRIM281.90295390
20CAMKK21.87568011
21MAP3K91.83577681
22BCKDK1.82552336
23MAPK131.75377205
24STK161.69310955
25TAOK31.56873898
26IRAK21.50516692
27CSNK1G21.45227062
28TSSK61.35533240
29MAP3K41.32225815
30PRKCG1.31836823
31ZAK1.23109355
32PASK1.20335791
33PAK31.15206554
34MAP3K61.14286994
35SRPK11.11487406
36VRK11.10841614
37STK391.07633150
38NTRK20.99262879
39WEE10.97422178
40PDK20.96271599
41DMPK0.93678095
42VRK20.90155520
43CAMKK10.90129560
44EPHA30.89922961
45NUAK10.88064400
46DYRK30.87365555
47KSR20.87318680
48ADRBK20.86208477
49FGFR20.85325371
50BRSK20.83720354
51ADRBK10.82490747
52LRRK20.80601650
53BUB10.79256672
54MINK10.78972307
55BRD40.78401711
56EPHB20.78181839
57PINK10.78123332
58PAK60.77549733
59ILK0.72456764
60KSR10.72360286
61DYRK1A0.68770414
62GRK10.65764071
63INSRR0.64965895
64BCR0.63458521
65PIK3CA0.63346451
66TESK20.62179694
67PRKACA0.56534777
68FRK0.55442090
69CDK50.54119935
70AURKA0.49460518
71NTRK30.46416333
72CCNB10.46299707
73BRSK10.45805521
74PBK0.45447511
75PLK30.45280513
76PRKACB0.44890565
77PRKCE0.39738440
78CDC70.39167978
79RAF10.38766139
80ACVR1B0.38220537
81EIF2AK10.35119199
82MAPKAPK50.34977943
83CAMK10.34788252
84CSNK1G30.34664729
85PRKCZ0.33810443
86DAPK20.33697580
87ROCK20.32968025
88PRKD30.32694890
89CDK140.32679216
90PHKG20.32069307
91PHKG10.32069307
92MAP2K60.31938917
93CSNK2A10.30954071
94OBSCN0.30300651
95CAMK1G0.29953207
96PLK10.29920949
97CSNK1E0.29478688
98SGK10.29339570
99AKT20.29096638
100CDK150.28258349

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.18367295
2Oxidative phosphorylation_Homo sapiens_hsa001905.15300745
3Parkinsons disease_Homo sapiens_hsa050124.53057703
4Huntingtons disease_Homo sapiens_hsa050163.24644163
5Alzheimers disease_Homo sapiens_hsa050103.14154081
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.05474022
7Cardiac muscle contraction_Homo sapiens_hsa042603.05040207
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.81379361
9Protein export_Homo sapiens_hsa030602.71577987
10RNA polymerase_Homo sapiens_hsa030202.38304882
11Nicotine addiction_Homo sapiens_hsa050332.31835366
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04927802
13Nitrogen metabolism_Homo sapiens_hsa009101.62971772
14Proteasome_Homo sapiens_hsa030501.60433344
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56394762
16Selenocompound metabolism_Homo sapiens_hsa004501.44864849
17One carbon pool by folate_Homo sapiens_hsa006701.44677774
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42909382
19Spliceosome_Homo sapiens_hsa030401.42196345
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.41204607
21Collecting duct acid secretion_Homo sapiens_hsa049661.33138642
22Phototransduction_Homo sapiens_hsa047441.32930799
23GABAergic synapse_Homo sapiens_hsa047271.29292308
24Pyrimidine metabolism_Homo sapiens_hsa002401.29033843
25Morphine addiction_Homo sapiens_hsa050321.22769558
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21916939
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21291206
28Homologous recombination_Homo sapiens_hsa034401.15983907
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15359338
30Butanoate metabolism_Homo sapiens_hsa006501.00665783
31Serotonergic synapse_Homo sapiens_hsa047260.94102985
32Purine metabolism_Homo sapiens_hsa002300.93901887
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90635569
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89029809
35Fanconi anemia pathway_Homo sapiens_hsa034600.85851317
36Glutamatergic synapse_Homo sapiens_hsa047240.83179403
37Metabolic pathways_Homo sapiens_hsa011000.82049441
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81761638
39RNA degradation_Homo sapiens_hsa030180.77928378
40Steroid hormone biosynthesis_Homo sapiens_hsa001400.76425498
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76362830
42RNA transport_Homo sapiens_hsa030130.76119682
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70927356
44Axon guidance_Homo sapiens_hsa043600.69500177
45Peroxisome_Homo sapiens_hsa041460.68084074
46Steroid biosynthesis_Homo sapiens_hsa001000.62648656
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.61586614
48Linoleic acid metabolism_Homo sapiens_hsa005910.61323645
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60923195
50Taste transduction_Homo sapiens_hsa047420.58117416
51Chemical carcinogenesis_Homo sapiens_hsa052040.57814670
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56414615
53Olfactory transduction_Homo sapiens_hsa047400.55636787
54Fatty acid elongation_Homo sapiens_hsa000620.53541408
55Synaptic vesicle cycle_Homo sapiens_hsa047210.53238715
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52520732
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52251890
58Circadian entrainment_Homo sapiens_hsa047130.50841418
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47325063
60Folate biosynthesis_Homo sapiens_hsa007900.47123926
61Glutathione metabolism_Homo sapiens_hsa004800.46325382
62Tryptophan metabolism_Homo sapiens_hsa003800.46271121
63Pyruvate metabolism_Homo sapiens_hsa006200.45821074
64Alcoholism_Homo sapiens_hsa050340.45316561
65Ether lipid metabolism_Homo sapiens_hsa005650.42751622
66Cocaine addiction_Homo sapiens_hsa050300.42535405
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.42205374
68Dopaminergic synapse_Homo sapiens_hsa047280.42192624
69Sulfur relay system_Homo sapiens_hsa041220.41254880
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40510975
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40369058
72Cholinergic synapse_Homo sapiens_hsa047250.38953255
73Basal transcription factors_Homo sapiens_hsa030220.38457919
74DNA replication_Homo sapiens_hsa030300.38338692
75Base excision repair_Homo sapiens_hsa034100.37411377
76Glycerolipid metabolism_Homo sapiens_hsa005610.36924222
77TGF-beta signaling pathway_Homo sapiens_hsa043500.35433610
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35355215
79Calcium signaling pathway_Homo sapiens_hsa040200.35235024
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34672364
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34603800
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34586022
83Mismatch repair_Homo sapiens_hsa034300.34062238
84Gap junction_Homo sapiens_hsa045400.33451004
85Hedgehog signaling pathway_Homo sapiens_hsa043400.32831825
86Basal cell carcinoma_Homo sapiens_hsa052170.30963029
87Tyrosine metabolism_Homo sapiens_hsa003500.30666441
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.30503256
89Fatty acid metabolism_Homo sapiens_hsa012120.30212078
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.29394777
91beta-Alanine metabolism_Homo sapiens_hsa004100.23067258
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23012291
93Systemic lupus erythematosus_Homo sapiens_hsa053220.21567259
94Fat digestion and absorption_Homo sapiens_hsa049750.20848127
95Insulin secretion_Homo sapiens_hsa049110.20241851
96mRNA surveillance pathway_Homo sapiens_hsa030150.16323846
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.15369056
98Propanoate metabolism_Homo sapiens_hsa006400.13909287
99Dorso-ventral axis formation_Homo sapiens_hsa043200.13382148
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.13270451

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