ASPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.56880480
2* ensheathment of neurons (GO:0007272)6.55687659
3* axon ensheathment (GO:0008366)6.55687659
4* myelination (GO:0042552)6.48065890
5long-chain fatty acid biosynthetic process (GO:0042759)6.34159659
6myelin maintenance (GO:0043217)6.12812739
7negative regulation of protein localization to cell surface (GO:2000009)4.90574644
8cholesterol biosynthetic process (GO:0006695)4.87625293
9response to methylmercury (GO:0051597)4.86183979
10establishment of mitochondrion localization (GO:0051654)4.83561626
11negative regulation of neurotransmitter transport (GO:0051589)4.69843966
12regulation of collateral sprouting (GO:0048670)4.66303964
13amyloid precursor protein metabolic process (GO:0042982)4.62619028
14creatine metabolic process (GO:0006600)4.57763893
15negative regulation of neurotransmitter secretion (GO:0046929)4.55250552
16long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.46292431
17L-amino acid import (GO:0043092)4.40060698
18sterol biosynthetic process (GO:0016126)4.36523587
19oligodendrocyte differentiation (GO:0048709)4.33705721
20regulation of lipoprotein metabolic process (GO:0050746)4.28821549
21glycerophospholipid catabolic process (GO:0046475)4.26717549
22detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.24668673
23apical protein localization (GO:0045176)4.19480954
24long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.17293375
25gamma-aminobutyric acid transport (GO:0015812)4.13396141
26photoreceptor cell differentiation (GO:0046530)4.04346744
27eye photoreceptor cell differentiation (GO:0001754)4.04346744
28protein K11-linked deubiquitination (GO:0035871)4.03515577
29asymmetric protein localization (GO:0008105)4.01473865
30isoprenoid biosynthetic process (GO:0008299)3.98625776
31presynaptic membrane organization (GO:0097090)3.95569627
32fatty-acyl-CoA biosynthetic process (GO:0046949)3.95554783
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.91241570
34behavioral response to nicotine (GO:0035095)3.89349451
35response to lipoprotein particle (GO:0055094)3.86715837
36import into cell (GO:0098657)3.83097318
37astrocyte development (GO:0014002)3.79117588
38fatty-acyl-CoA metabolic process (GO:0035337)3.78917373
39membrane tubulation (GO:0097320)3.73342773
40tryptophan catabolic process (GO:0006569)3.72073675
41indole-containing compound catabolic process (GO:0042436)3.72073675
42indolalkylamine catabolic process (GO:0046218)3.72073675
43GPI anchor biosynthetic process (GO:0006506)3.70071518
44very long-chain fatty acid metabolic process (GO:0000038)3.68398576
45indolalkylamine metabolic process (GO:0006586)3.60369437
46response to redox state (GO:0051775)3.59357024
47GPI anchor metabolic process (GO:0006505)3.58842084
48negative regulation of cytosolic calcium ion concentration (GO:0051481)3.48909895
49serotonin metabolic process (GO:0042428)3.45558691
50amyloid precursor protein catabolic process (GO:0042987)3.43207712
51L-phenylalanine catabolic process (GO:0006559)3.42484536
52erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.42484536
53neuron remodeling (GO:0016322)3.41603124
54L-fucose catabolic process (GO:0042355)3.35183068
55fucose catabolic process (GO:0019317)3.35183068
56L-fucose metabolic process (GO:0042354)3.35183068
57primary amino compound metabolic process (GO:1901160)3.34938725
58protein palmitoylation (GO:0018345)3.34735382
59presynaptic membrane assembly (GO:0097105)3.31704820
60axon development (GO:0061564)3.30780884
61kynurenine metabolic process (GO:0070189)3.30031556
62magnesium ion transport (GO:0015693)3.29006360
63neurotransmitter uptake (GO:0001504)3.27814067
64response to pheromone (GO:0019236)3.26689934
65detection of light stimulus involved in sensory perception (GO:0050962)3.23713768
66detection of light stimulus involved in visual perception (GO:0050908)3.23713768
67peptidyl-tyrosine autophosphorylation (GO:0038083)3.22526032
68substantia nigra development (GO:0021762)3.22230154
69heme transport (GO:0015886)3.21590504
70reflex (GO:0060004)3.20474885
71limb bud formation (GO:0060174)3.20082228
72thioester biosynthetic process (GO:0035384)3.19550993
73acyl-CoA biosynthetic process (GO:0071616)3.19550993
74indole-containing compound metabolic process (GO:0042430)3.19291633
75tryptophan metabolic process (GO:0006568)3.16805231
76auditory receptor cell stereocilium organization (GO:0060088)3.16667698
77preassembly of GPI anchor in ER membrane (GO:0016254)3.15109506
78retinal cone cell development (GO:0046549)3.15013548
79protein neddylation (GO:0045116)3.13890582
80proline transport (GO:0015824)3.13725596
81amino acid import (GO:0043090)3.10184527
82transmission of nerve impulse (GO:0019226)3.09028165
83glycosylceramide metabolic process (GO:0006677)3.05078335
84adult walking behavior (GO:0007628)3.04958704
85neuronal action potential (GO:0019228)3.04772468
86iron coordination entity transport (GO:1901678)3.04434201
87nucleotide transmembrane transport (GO:1901679)3.04331965
88membrane depolarization during action potential (GO:0086010)3.02717862
89cerebral cortex radially oriented cell migration (GO:0021799)3.02319228
90myelination in peripheral nervous system (GO:0022011)3.00230967
91peripheral nervous system axon ensheathment (GO:0032292)3.00230967
92C4-dicarboxylate transport (GO:0015740)2.96456764
93negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.94498391
94startle response (GO:0001964)2.93896107
95negative regulation of execution phase of apoptosis (GO:1900118)2.92923400
96sulfation (GO:0051923)2.92394393
97positive regulation of cellular amine metabolic process (GO:0033240)2.92084706
98detection of mechanical stimulus involved in sensory perception (GO:0050974)2.91006220
99adhesion of symbiont to host cell (GO:0044650)2.90862850
100virion attachment to host cell (GO:0019062)2.90862850
101negative regulation of synaptic transmission, GABAergic (GO:0032229)2.88105021
102positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.87889477
103cellular ketone body metabolic process (GO:0046950)2.87846399
104synaptic vesicle maturation (GO:0016188)2.84977736
105G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.84115450
106L-phenylalanine metabolic process (GO:0006558)2.83934021
107erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.83934021
108photoreceptor cell maintenance (GO:0045494)2.83528550
109peptidyl-cysteine modification (GO:0018198)2.83277972
110organ growth (GO:0035265)2.82321726
111regulation of short-term neuronal synaptic plasticity (GO:0048172)2.81393444
112cyclic nucleotide catabolic process (GO:0009214)2.80668027
113negative regulation of JUN kinase activity (GO:0043508)2.80501990
114negative regulation of macroautophagy (GO:0016242)2.79299807
115response to lead ion (GO:0010288)2.78936507
116behavioral response to ethanol (GO:0048149)2.78115235
117tissue regeneration (GO:0042246)2.77702540
118enteric nervous system development (GO:0048484)2.77196357
119neural tube formation (GO:0001841)2.75366224
120negative regulation of chemokine production (GO:0032682)2.75256250
121response to dietary excess (GO:0002021)2.72140770
122positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.71727079
123gamma-aminobutyric acid signaling pathway (GO:0007214)2.71458366
124inner ear receptor stereocilium organization (GO:0060122)2.70412425
125cAMP catabolic process (GO:0006198)2.70260604
126cilium or flagellum-dependent cell motility (GO:0001539)2.68043188
127negative regulation of axonogenesis (GO:0050771)2.65953475
128regulation of neurotransmitter uptake (GO:0051580)2.65159410
129ketone body metabolic process (GO:1902224)2.65007279
130protein polyglutamylation (GO:0018095)2.64801123
131glial cell development (GO:0021782)2.64424748
132regulation of sarcomere organization (GO:0060297)2.64404795
133detection of temperature stimulus involved in sensory perception (GO:0050961)2.63415610
134detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.63415610
135synaptic transmission, glutamatergic (GO:0035249)2.61549294
136positive regulation of pseudopodium assembly (GO:0031274)2.61542326
137mannosylation (GO:0097502)2.60770952
138negative regulation of acute inflammatory response (GO:0002674)2.59753620
139establishment of protein localization to Golgi (GO:0072600)2.59301174
140microtubule polymerization or depolymerization (GO:0031109)2.58552685
141cellular potassium ion transport (GO:0071804)2.58512347
142potassium ion transmembrane transport (GO:0071805)2.58512347
143mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.58185513
144postsynaptic membrane organization (GO:0001941)2.57371129
145leukocyte migration involved in inflammatory response (GO:0002523)2.57319706
146regulation of somitogenesis (GO:0014807)2.57126805
147glutamate receptor signaling pathway (GO:0007215)2.55962144
148peripheral nervous system development (GO:0007422)2.55028504
149neuron cell-cell adhesion (GO:0007158)2.54876377
150dopamine transport (GO:0015872)2.54847509
151cranial nerve development (GO:0021545)2.53122842
152glycosphingolipid biosynthetic process (GO:0006688)2.51683918
153piRNA metabolic process (GO:0034587)2.51098565
154phosphorelay signal transduction system (GO:0000160)2.50048348
155signal peptide processing (GO:0006465)2.49761528
156amine catabolic process (GO:0009310)2.49483003
157cellular biogenic amine catabolic process (GO:0042402)2.49483003
158positive regulation of action potential (GO:0045760)2.48951077
159action potential (GO:0001508)2.48107093
160Golgi to endosome transport (GO:0006895)2.48075716
161thyroid hormone metabolic process (GO:0042403)2.47947026
162potassium ion transport (GO:0006813)2.47933538
163cellular response to sterol (GO:0036315)2.47679470
164neuronal action potential propagation (GO:0019227)2.47292800
165neuromuscular synaptic transmission (GO:0007274)2.44608261
166nucleotide transport (GO:0006862)2.44493057
167positive regulation of sodium ion transmembrane transport (GO:1902307)2.43084318
168axoneme assembly (GO:0035082)2.42793556
169drug catabolic process (GO:0042737)2.41557896
170interkinetic nuclear migration (GO:0022027)2.41286566
171righting reflex (GO:0060013)2.41210636
172negative regulation of mast cell activation (GO:0033004)2.40892694
173epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.39731746
174neuron-neuron synaptic transmission (GO:0007270)2.39386747
175regulation of pigment cell differentiation (GO:0050932)2.37817586
176regulation of hippo signaling (GO:0035330)2.37723403
177ionotropic glutamate receptor signaling pathway (GO:0035235)2.37460057
178aromatic amino acid family catabolic process (GO:0009074)2.35843508
179NAD biosynthetic process (GO:0009435)2.34724785
180protein K63-linked deubiquitination (GO:0070536)2.33318522
181positive regulation of meiosis (GO:0045836)2.32193109
182regulation of action potential (GO:0098900)2.31170882
183regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.30124327
184serotonin receptor signaling pathway (GO:0007210)2.26328578
185photoreceptor cell development (GO:0042461)2.26324501
186DNA methylation involved in gamete generation (GO:0043046)2.26252580
187oxidative demethylation (GO:0070989)2.26072167
188flavonoid metabolic process (GO:0009812)2.25870580
189synaptic vesicle docking involved in exocytosis (GO:0016081)2.25323055
190potassium ion import (GO:0010107)2.24241537
191* central nervous system myelination (GO:0022010)11.2781504
192* axon ensheathment in central nervous system (GO:0032291)11.2781504

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.36141309
2SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.74285148
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.61329992
4ZNF274_21170338_ChIP-Seq_K562_Hela2.60811987
5TAF15_26573619_Chip-Seq_HEK293_Human2.40553955
6OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.16132827
7EZH2_22144423_ChIP-Seq_EOC_Human2.15036718
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13384335
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13109125
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06122252
11FLI1_27457419_Chip-Seq_LIVER_Mouse1.97567463
12JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87652699
13VDR_22108803_ChIP-Seq_LS180_Human1.87220291
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85742664
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.82135481
16ER_23166858_ChIP-Seq_MCF-7_Human1.81979651
17AR_21572438_ChIP-Seq_LNCaP_Human1.81940146
18MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81850468
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79950385
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76008309
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.74733629
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.73022510
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72470872
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72470872
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71138312
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70940109
27EWS_26573619_Chip-Seq_HEK293_Human1.69067324
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67942983
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67382018
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62584402
31BCAT_22108803_ChIP-Seq_LS180_Human1.61399767
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60098554
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60091008
34STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.58373012
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58126157
36REST_21632747_ChIP-Seq_MESCs_Mouse1.58119466
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.56746379
38AR_25329375_ChIP-Seq_VCAP_Human1.55292063
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49252222
40CBP_20019798_ChIP-Seq_JUKART_Human1.48044984
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48044984
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45666172
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43996407
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.43968318
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43677929
46* SMAD3_21741376_ChIP-Seq_EPCs_Human1.43218332
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42150187
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42150187
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.41420710
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41368521
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.40581594
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38523718
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.38208374
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37684062
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36124690
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36124690
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34143473
58TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33268775
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.32535156
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32347283
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31441510
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31372479
63TCF4_22108803_ChIP-Seq_LS180_Human1.30811019
64P300_19829295_ChIP-Seq_ESCs_Human1.30091929
65FLI1_21867929_ChIP-Seq_TH2_Mouse1.29421010
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29050081
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27989242
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.26929087
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25690326
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.25570237
71RUNX2_22187159_ChIP-Seq_PCA_Human1.25296900
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24982980
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24485906
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.22645370
75FUS_26573619_Chip-Seq_HEK293_Human1.20701855
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20435021
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19856078
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19428706
79HTT_18923047_ChIP-ChIP_STHdh_Human1.19354808
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18262708
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18198735
82* CRX_20693478_ChIP-Seq_RETINA_Mouse1.17676169
83* SMAD4_21741376_ChIP-Seq_EPCs_Human1.17556744
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16956089
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.16303066
86CMYC_18555785_Chip-Seq_ESCs_Mouse1.16152141
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.15253581
88EOMES_21245162_ChIP-Seq_HESCs_Human1.15064481
89DROSHA_22980978_ChIP-Seq_HELA_Human1.14762903
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.12751979
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12705565
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.12648275
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12454990
94* LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11790344
95FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11587612
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11176713
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10967412
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10508646
99CDX2_22108803_ChIP-Seq_LS180_Human1.10277582
100TP53_22573176_ChIP-Seq_HFKS_Human1.09712196
101TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09006600
102OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07714515
103STAT3_23295773_ChIP-Seq_U87_Human1.07605738
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07458600
105EP300_21415370_ChIP-Seq_HL-1_Mouse1.06763649
106P300_18555785_Chip-Seq_ESCs_Mouse1.06166669
107SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05791681
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05699031
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.05606921
110RNF2_27304074_Chip-Seq_NSC_Mouse1.04561870
111SOX2_19829295_ChIP-Seq_ESCs_Human1.03357781
112NANOG_19829295_ChIP-Seq_ESCs_Human1.03357781
113CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03119496
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02336034
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02244447
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01820098
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.00623817
118SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.00221560
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00135033
120TP53_16413492_ChIP-PET_HCT116_Human0.98871392
121IGF1R_20145208_ChIP-Seq_DFB_Human0.98544142
122TRIM28_21343339_ChIP-Seq_HEK293_Human0.97491159
123TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97210501
124P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96041849
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94875397
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94797088
127* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94568179
128SMAD4_21799915_ChIP-Seq_A2780_Human0.94392690
129IRF1_19129219_ChIP-ChIP_H3396_Human0.94337173
130TCF4_23295773_ChIP-Seq_U87_Human0.93329109
131KDM2B_26808549_Chip-Seq_REH_Human0.93228685
132EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91971318
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91264738
134AHR_22903824_ChIP-Seq_MCF-7_Human0.90708374
135STAT3_18555785_Chip-Seq_ESCs_Mouse0.89936572
136P53_22387025_ChIP-Seq_ESCs_Mouse0.89279397
137RUNX1_27457419_Chip-Seq_LIVER_Mouse0.88758973
138WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87615871
139KLF4_18555785_Chip-Seq_ESCs_Mouse0.87598379
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87498292
141PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87446937
142GATA1_26923725_Chip-Seq_HPCs_Mouse0.86994668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0000920_abnormal_myelination5.41910262
2MP0003950_abnormal_plasma_membrane4.27872836
3MP0000569_abnormal_digit_pigmentation3.76561960
4MP0003880_abnormal_central_pattern3.19612850
5MP0003690_abnormal_glial_cell3.15148690
6MP0004270_analgesia3.03541866
7MP0003329_amyloid_beta_deposits2.94216049
8MP0001529_abnormal_vocalization2.93785692
9MP0003136_yellow_coat_color2.81985578
10MP0005171_absent_coat_pigmentation2.76410033
11MP0004885_abnormal_endolymph2.63307634
12MP0001501_abnormal_sleep_pattern2.62904182
13MP0004043_abnormal_pH_regulation2.57843430
14MP0003646_muscle_fatigue2.49489525
15MP0004742_abnormal_vestibular_system2.47853794
16MP0001905_abnormal_dopamine_level2.39880331
17MP0002272_abnormal_nervous_system2.34069163
18MP0004142_abnormal_muscle_tone2.33730734
19MP0001486_abnormal_startle_reflex2.30098364
20MP0003806_abnormal_nucleotide_metabolis2.22509998
21MP0008877_abnormal_DNA_methylation2.21387624
22MP0005410_abnormal_fertilization2.16684062
23MP0005409_darkened_coat_color2.15198397
24* MP0003634_abnormal_glial_cell2.12537444
25MP0001485_abnormal_pinna_reflex2.03200248
26MP0005646_abnormal_pituitary_gland1.98486966
27MP0010678_abnormal_skin_adnexa1.90324331
28MP0008260_abnormal_autophagy1.86443738
29MP0003632_abnormal_nervous_system1.84112970
30MP0000778_abnormal_nervous_system1.82911352
31MP0003787_abnormal_imprinting1.82240514
32MP0004381_abnormal_hair_follicle1.78647125
33MP0005423_abnormal_somatic_nervous1.77446982
34* MP0002064_seizures1.75524703
35MP0002876_abnormal_thyroid_physiology1.71604344
36MP0006276_abnormal_autonomic_nervous1.71141853
37MP0002102_abnormal_ear_morphology1.70682558
38* MP0002229_neurodegeneration1.69780900
39MP0001984_abnormal_olfaction1.68653007
40MP0005670_abnormal_white_adipose1.67565852
41MP0008872_abnormal_physiological_respon1.67386447
42MP0000383_abnormal_hair_follicle1.67095174
43MP0003195_calcinosis1.63877475
44MP0002638_abnormal_pupillary_reflex1.63341214
45MP0005174_abnormal_tail_pigmentation1.62509153
46MP0005451_abnormal_body_composition1.61815354
47MP0000604_amyloidosis1.60996546
48MP0003631_nervous_system_phenotype1.56592491
49MP0002837_dystrophic_cardiac_calcinosis1.55971923
50MP0000462_abnormal_digestive_system1.55065542
51MP0004147_increased_porphyrin_level1.52220007
52MP0009046_muscle_twitch1.48252095
53MP0000427_abnormal_hair_cycle1.44450016
54MP0003633_abnormal_nervous_system1.44268603
55MP0002734_abnormal_mechanical_nocicepti1.43313124
56MP0005551_abnormal_eye_electrophysiolog1.39436793
57MP0000566_synostosis1.38660791
58MP0001986_abnormal_taste_sensitivity1.38621581
59MP0004134_abnormal_chest_morphology1.36841979
60MP0005645_abnormal_hypothalamus_physiol1.36414025
61MP0009745_abnormal_behavioral_response1.34503478
62MP0001346_abnormal_lacrimal_gland1.32406100
63MP0008057_abnormal_DNA_replication1.32288277
64MP0002557_abnormal_social/conspecific_i1.32259992
65MP0004215_abnormal_myocardial_fiber1.30170568
66MP0005167_abnormal_blood-brain_barrier1.29757702
67MP0006072_abnormal_retinal_apoptosis1.26315555
68MP0004130_abnormal_muscle_cell1.26023507
69MP0008875_abnormal_xenobiotic_pharmacok1.25076239
70MP0010386_abnormal_urinary_bladder1.24582622
71MP0000955_abnormal_spinal_cord1.22748188
72MP0001963_abnormal_hearing_physiology1.19163441
73MP0000747_muscle_weakness1.18514228
74MP0001661_extended_life_span1.17075539
75MP0008569_lethality_at_weaning1.14530691
76MP0004859_abnormal_synaptic_plasticity1.14238676
77* MP0003635_abnormal_synaptic_transmissio1.14158951
78MP0005058_abnormal_lysosome_morphology1.13439351
79MP0002882_abnormal_neuron_morphology1.13144488
80MP0002572_abnormal_emotion/affect_behav1.10361710
81MP0000647_abnormal_sebaceous_gland1.10254605
82MP0003878_abnormal_ear_physiology1.08935335
83MP0005377_hearing/vestibular/ear_phenot1.08935335
84* MP0002066_abnormal_motor_capabilities/c1.08484912
85MP0000631_abnormal_neuroendocrine_gland1.08327978
86MP0002138_abnormal_hepatobiliary_system1.07111296
87MP0009840_abnormal_foam_cell1.05432057
88MP0001440_abnormal_grooming_behavior1.03896748
89MP0003879_abnormal_hair_cell1.03491371
90MP0002752_abnormal_somatic_nervous1.02832258
91MP0002067_abnormal_sensory_capabilities1.02768620
92MP0000230_abnormal_systemic_arterial1.01424461
93MP0005386_behavior/neurological_phenoty1.01023157
94MP0004924_abnormal_behavior1.01023157
95MP0010329_abnormal_lipoprotein_level1.00266008
96MP0001851_eye_inflammation1.00021035
97MP0003045_fibrosis0.99649578
98MP0000762_abnormal_tongue_morphology0.97970129
99MP0005085_abnormal_gallbladder_physiolo0.97506964
100MP0000579_abnormal_nail_morphology0.97229347
101MP0006082_CNS_inflammation0.96308573
102MP0000015_abnormal_ear_pigmentation0.93207201
103MP0003938_abnormal_ear_development0.92023867
104MP0002063_abnormal_learning/memory/cond0.91277405
105MP0001502_abnormal_circadian_rhythm0.91076532
106MP0002295_abnormal_pulmonary_circulatio0.90549248
107* MP0001970_abnormal_pain_threshold0.90443462
108* MP0005195_abnormal_posterior_eye0.90058368
109MP0005408_hypopigmentation0.88563848
110MP0005623_abnormal_meninges_morphology0.88313996
111MP0001299_abnormal_eye_distance/0.88110371
112MP0002095_abnormal_skin_pigmentation0.87467729
113MP0004145_abnormal_muscle_electrophysio0.85731120
114MP0008438_abnormal_cutaneous_collagen0.85564720
115MP0001348_abnormal_lacrimal_gland0.83574508
116MP0004085_abnormal_heartbeat0.83448283
117MP0005389_reproductive_system_phenotype0.82248983
118MP0002160_abnormal_reproductive_system0.79508860
119MP0002733_abnormal_thermal_nociception0.79284832
120MP0001177_atelectasis0.78968753
121MP0000026_abnormal_inner_ear0.78342535
122MP0003937_abnormal_limbs/digits/tail_de0.76513117
123MP0004036_abnormal_muscle_relaxation0.75530360
124MP0003656_abnormal_erythrocyte_physiolo0.74958160
125MP0002928_abnormal_bile_duct0.74848076
126MP0004484_altered_response_of0.74684627
127MP0002735_abnormal_chemical_nociception0.74466666
128MP0002184_abnormal_innervation0.74199742
129MP0002938_white_spotting0.73635507
130MP0000467_abnormal_esophagus_morphology0.71846587
131MP0002653_abnormal_ependyma_morphology0.71496086
132MP0005535_abnormal_body_temperature0.71307997
133MP0005075_abnormal_melanosome_morpholog0.70633424
134MP0001968_abnormal_touch/_nociception0.65275318
135MP0000749_muscle_degeneration0.64019355
136MP0002736_abnormal_nociception_after0.62746039
137MP0005253_abnormal_eye_physiology0.62537141
138MP0001340_abnormal_eyelid_morphology0.62522137
139MP0005332_abnormal_amino_acid0.62118864
140MP0002118_abnormal_lipid_homeostasis0.61499332
141MP0004185_abnormal_adipocyte_glucose0.60951044
142* MP0002152_abnormal_brain_morphology0.59020851
143MP0002133_abnormal_respiratory_system0.57683019
144MP0005388_respiratory_system_phenotype0.57683019
145MP0000372_irregular_coat_pigmentation0.57429050
146MP0003137_abnormal_impulse_conducting0.57050268
147MP0000003_abnormal_adipose_tissue0.56784616

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.81690441
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.81690441
3Neurofibrillary tangles (HP:0002185)6.31914328
4Abnormality of the corticospinal tract (HP:0002492)4.95908127
5Parakeratosis (HP:0001036)4.76573566
6Peripheral hypomyelination (HP:0007182)4.49736994
7Cerebral inclusion bodies (HP:0100314)4.48566488
8Hyperventilation (HP:0002883)4.45674909
9Pancreatic cysts (HP:0001737)4.18884753
10Onion bulb formation (HP:0003383)4.06527757
11Febrile seizures (HP:0002373)3.86831857
12Sensory axonal neuropathy (HP:0003390)3.84454340
13Gaze-evoked nystagmus (HP:0000640)3.78624709
14Pancreatic fibrosis (HP:0100732)3.74009965
15Termporal pattern (HP:0011008)3.65757342
16Insidious onset (HP:0003587)3.65757342
17Congenital stationary night blindness (HP:0007642)3.64026307
18Focal motor seizures (HP:0011153)3.63136737
19True hermaphroditism (HP:0010459)3.60759753
20Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.55453726
21Cerebral hypomyelination (HP:0006808)3.54182315
22Abnormal auditory evoked potentials (HP:0006958)3.53316518
23Increased serum pyruvate (HP:0003542)3.50087291
24Abnormality of glycolysis (HP:0004366)3.50087291
25Molar tooth sign on MRI (HP:0002419)3.48656640
26Abnormality of midbrain morphology (HP:0002418)3.48656640
27Progressive cerebellar ataxia (HP:0002073)3.48418035
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.41623702
29Focal seizures (HP:0007359)3.37374453
30Segmental peripheral demyelination/remyelination (HP:0003481)3.34795817
31Spastic gait (HP:0002064)3.31116645
32Supranuclear gaze palsy (HP:0000605)3.29674958
33Genetic anticipation (HP:0003743)3.21976401
34Leukodystrophy (HP:0002415)3.18816318
35Alacrima (HP:0000522)3.17149118
36Abnormality of the renal cortex (HP:0011035)3.16818235
37Nephronophthisis (HP:0000090)3.16054861
38Abnormality of the renal medulla (HP:0100957)2.97253422
39Attenuation of retinal blood vessels (HP:0007843)2.95591425
40Absent speech (HP:0001344)2.94894181
41Dialeptic seizures (HP:0011146)2.91781549
42Atonic seizures (HP:0010819)2.88543715
43Intention tremor (HP:0002080)2.87508362
44Abolished electroretinogram (ERG) (HP:0000550)2.83289026
45Broad-based gait (HP:0002136)2.82376580
46Anteriorly placed anus (HP:0001545)2.81883264
47Dysmetria (HP:0001310)2.79864688
48Cystic liver disease (HP:0006706)2.78623667
49Chronic hepatic failure (HP:0100626)2.77834539
50Abnormal drinking behavior (HP:0030082)2.77435165
51Polydipsia (HP:0001959)2.77435165
52Ankle clonus (HP:0011448)2.76483738
53Scanning speech (HP:0002168)2.75921662
54Retinal dysplasia (HP:0007973)2.74719891
55Stridor (HP:0010307)2.73596724
56Congenital sensorineural hearing impairment (HP:0008527)2.73557808
57Medial flaring of the eyebrow (HP:0010747)2.70892596
58Cerebral hemorrhage (HP:0001342)2.70640910
59Fair hair (HP:0002286)2.65217343
60Type II lissencephaly (HP:0007260)2.64285138
61Decreased circulating renin level (HP:0003351)2.63939604
62Axonal loss (HP:0003447)2.63587765
63Metabolic alkalosis (HP:0200114)2.63421734
64Absent septum pellucidum (HP:0001331)2.63301851
65Stomach cancer (HP:0012126)2.62783623
66Autoamputation (HP:0001218)2.62753695
67Inability to walk (HP:0002540)2.62714447
68Abnormality of alanine metabolism (HP:0010916)2.62041164
69Hyperalaninemia (HP:0003348)2.62041164
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.62041164
71Clumsiness (HP:0002312)2.61313543
72Congenital ichthyosiform erythroderma (HP:0007431)2.59261383
73Increased circulating renin level (HP:0000848)2.57951618
74Slow saccadic eye movements (HP:0000514)2.56797825
75Large for gestational age (HP:0001520)2.53095223
76Myokymia (HP:0002411)2.52632987
77Absence seizures (HP:0002121)2.52524730
78Spastic paraparesis (HP:0002313)2.50998317
79Protruding tongue (HP:0010808)2.49565407
80CNS hypomyelination (HP:0003429)2.45823034
81Hemiparesis (HP:0001269)2.45804112
82Thickened helices (HP:0000391)2.44469582
83Abnormality of aromatic amino acid family metabolism (HP:0004338)2.41923434
84Premature skin wrinkling (HP:0100678)2.40741227
85Aplasia/Hypoplasia of the tibia (HP:0005772)2.40399232
86Progressive inability to walk (HP:0002505)2.39846044
87Hypokalemic alkalosis (HP:0001949)2.38454649
88Epileptic encephalopathy (HP:0200134)2.38395558
89Decreased lacrimation (HP:0000633)2.37376461
90Tubular atrophy (HP:0000092)2.37064058
91Hypoplastic pelvis (HP:0008839)2.37059880
92Patchy hypopigmentation of hair (HP:0011365)2.35809604
93Hypophosphatemic rickets (HP:0004912)2.35495276
94Keratoconus (HP:0000563)2.33423236
95Increased corneal curvature (HP:0100692)2.33423236
96White forelock (HP:0002211)2.33296375
97Muscle fiber splitting (HP:0003555)2.32477724
98Morphological abnormality of the inner ear (HP:0011390)2.31681364
99Pheochromocytoma (HP:0002666)2.31670422
100Split foot (HP:0001839)2.31214170
101Generalized hypopigmentation of hair (HP:0011358)2.30739793
102Abnormality of the phalanges of the 2nd finger (HP:0009541)2.30404397
103Hypomagnesemia (HP:0002917)2.30286570
104Spastic tetraparesis (HP:0001285)2.30249741
105Hypoplasia of the iris (HP:0007676)2.29931329
106Gait imbalance (HP:0002141)2.28782874
107Coronal craniosynostosis (HP:0004440)2.28687943
108Hepatosplenomegaly (HP:0001433)2.26794151
109Decreased central vision (HP:0007663)2.26657045
110Renal cortical cysts (HP:0000803)2.26460099
111Abnormality of the septum pellucidum (HP:0007375)2.25607905
112Foot dorsiflexor weakness (HP:0009027)2.24101697
113Polyuria (HP:0000103)2.21701130
114Aplasia involving bones of the upper limbs (HP:0009823)2.17116936
115Aplasia of the phalanges of the hand (HP:0009802)2.17116936
116Aplasia involving bones of the extremities (HP:0009825)2.17116936
117Methylmalonic acidemia (HP:0002912)2.12807927
118Partial duplication of thumb phalanx (HP:0009944)2.07855526
119Decreased motor nerve conduction velocity (HP:0003431)2.07512917
120Bony spicule pigmentary retinopathy (HP:0007737)2.07124755
121Congenital primary aphakia (HP:0007707)2.06470891
122Acute necrotizing encephalopathy (HP:0006965)2.05606020
123Peripheral demyelination (HP:0011096)2.05106807
124Lower limb muscle weakness (HP:0007340)2.04960213
125Furrowed tongue (HP:0000221)2.04003026
126Congenital hepatic fibrosis (HP:0002612)2.03597035
127Widely spaced teeth (HP:0000687)2.02048586
128Abnormality of the foot musculature (HP:0001436)2.01822137
129Neuroendocrine neoplasm (HP:0100634)1.99728771
130Infantile muscular hypotonia (HP:0008947)1.99643349
131Renal Fanconi syndrome (HP:0001994)1.99043109
132Prolonged QT interval (HP:0001657)1.98990664
133Genital tract atresia (HP:0001827)1.98212563
134Generalized tonic-clonic seizures (HP:0002069)1.94187921
135Acute encephalopathy (HP:0006846)1.93386457
136Aplasia/Hypoplasia of the tongue (HP:0010295)1.93296170
137Abnormality of the middle phalanges of the toes (HP:0010183)1.92886930
138Abnormal rod and cone electroretinograms (HP:0008323)1.92513341
139Urinary bladder sphincter dysfunction (HP:0002839)1.92122774
140Cerebellar dysplasia (HP:0007033)1.91082246
141Pendular nystagmus (HP:0012043)1.90794812
142Chorioretinal atrophy (HP:0000533)1.90300732
143Prolonged neonatal jaundice (HP:0006579)1.90064876
144Hypothermia (HP:0002045)1.89890678
145Gowers sign (HP:0003391)1.88357478
146Poor speech (HP:0002465)1.88084927
147Nephrogenic diabetes insipidus (HP:0009806)1.87650547
148Abnormal urine output (HP:0012590)1.86818341
149Abnormality of renin-angiotensin system (HP:0000847)1.86634173
150Hyperglycinuria (HP:0003108)1.86372972
151Vaginal atresia (HP:0000148)1.86290096
152Paraparesis (HP:0002385)1.86193609
153Hyporeflexia of lower limbs (HP:0002600)1.85855358
154Partial agenesis of the corpus callosum (HP:0001338)1.85254825
155Esophageal atresia (HP:0002032)1.84161565
156Megalencephaly (HP:0001355)1.84127167
157Akinesia (HP:0002304)1.82834998
1583-Methylglutaconic aciduria (HP:0003535)1.82719905
159Abnormal biliary tract physiology (HP:0012439)1.81616910
160Bile duct proliferation (HP:0001408)1.81616910
161Synostosis involving the elbow (HP:0003938)1.81602257
162Humeroradial synostosis (HP:0003041)1.81602257
163Action tremor (HP:0002345)1.81558361
164Drooling (HP:0002307)1.81359568
165Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81169273
166Sclerocornea (HP:0000647)1.80949888
167Intestinal atresia (HP:0011100)1.80094409
168Diplopia (HP:0000651)1.79260582
169Abnormality of binocular vision (HP:0011514)1.79260582
170Choreoathetosis (HP:0001266)1.78905527
171Lissencephaly (HP:0001339)1.78610050
172Ketoacidosis (HP:0001993)1.76813683
173Diaphragmatic weakness (HP:0009113)1.76433118
174Hemiplegia (HP:0002301)1.74774600
175Clonus (HP:0002169)1.74398400
176Cupped ear (HP:0000378)1.73262187
177Partial duplication of the phalanx of hand (HP:0009999)1.73001825
178Hammertoe (HP:0001765)1.72773076
179Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.71529741
180Limb dystonia (HP:0002451)1.71281730
181Morphological abnormality of the pyramidal tract (HP:0002062)1.70464683
182Poor coordination (HP:0002370)1.69607860
183Syncope (HP:0001279)1.69261452
184Erythroderma (HP:0001019)1.69184069
185Optic nerve hypoplasia (HP:0000609)1.68125512
186Hyperaldosteronism (HP:0000859)1.68015504
187Ketosis (HP:0001946)1.67300290
188Distal sensory impairment (HP:0002936)1.67166374
189Urinary incontinence (HP:0000020)1.67088729
190Male pseudohermaphroditism (HP:0000037)1.66937154
191Anencephaly (HP:0002323)1.66766538
192Small hand (HP:0200055)1.65937984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.20134204
2STK396.49555306
3OXSR14.76068324
4EPHB13.49096238
5ACVR1B3.27638823
6MAPKAPK52.96167328
7PBK2.95803922
8PKN12.94240266
9WNK42.69033674
10MET2.55146961
11FGFR22.42707111
12BCR2.40390142
13MAP4K22.20309959
14NTRK32.17627227
15CDK192.13735021
16TESK22.06977521
17LIMK12.00859202
18MST41.95327876
19WNK11.90922822
20DAPK21.90772512
21CAMK2B1.73944029
22CSNK1G31.72768392
23CSNK1A1L1.71450650
24PNCK1.69997863
25INSRR1.63414203
26TAOK31.57930594
27UHMK11.52876317
28MAP3K41.44671686
29ROCK21.43502165
30NUAK11.42954547
31NTRK11.42327131
32CAMK2D1.41858538
33CSNK1G11.40800909
34CASK1.40770553
35CLK11.38938569
36SGK4941.38047749
37SGK2231.38047749
38NEK61.37682024
39FGR1.33111353
40MUSK1.31869435
41CAMKK21.30098039
42ZAK1.29546845
43STK38L1.25970337
44BMPR1B1.25067998
45CSNK1G21.22500313
46PLK21.16622409
47CAMK2G1.15026429
48DYRK21.14668919
49PIK3CG1.10648357
50ADRBK11.05358710
51MKNK21.03445556
52TRIM281.00365510
53AKT30.99073257
54PRKCG0.97659946
55MAP2K60.96508074
56TLK10.96055248
57TXK0.94378271
58PAK60.90719926
59SGK20.89888571
60CAMK2A0.89308119
61MARK20.87840875
62EPHA40.86600217
63ERBB40.86490666
64MAPK150.84200979
65CAMK10.84123215
66PRKD10.83839423
67PRKCQ0.83344279
68PRPF4B0.81137793
69MARK10.79733792
70ICK0.77930007
71TNIK0.77689786
72RPS6KA50.77449605
73TRPM70.76341324
74GRK50.75622726
75CDK140.71846083
76CDK50.71796911
77PRKCE0.71681436
78TIE10.71496822
79PAK30.70197061
80TGFBR10.69811832
81LATS10.68414287
82PHKG20.65973005
83PHKG10.65973005
84CDK150.65078094
85FER0.64392080
86MAPKAPK30.63152086
87PDPK10.62816629
88MAP2K70.62450509
89PRKAA20.61804109
90GSK3A0.59940119
91CDK180.59611965
92NLK0.59523546
93ERBB30.58725929
94MINK10.58196804
95TYRO30.57573337
96TNK20.57489553
97CDK11A0.57472189
98TEC0.52211867
99CAMK1D0.52198570
100MKNK10.52154521
101CSNK1D0.50426844
102PRKG10.50200049
103CAMK40.49878080
104PRKCZ0.49397977
105MAP2K20.48780778
106STK380.48505582
107FYN0.48341688
108PRKAA10.47438089
109ARAF0.47418524
110PIK3CA0.46666560
111PRKACB0.46470582
112CSNK1A10.46347658
113PDK20.44746661
114WNK30.44731760
115GRK70.44359297
116OBSCN0.42179359
117CAMK1G0.40404149
118PRKCA0.39767601
119STK30.39707994
120MAP2K10.39179589
121PTK2B0.39093190
122KIT0.39007796
123CAMKK10.38980148
124IRAK10.38970146
125PRKCH0.37623087
126ADRBK20.37376495
127DAPK30.36183058
128PAK10.35867160
129RPS6KA30.35455904
130NTRK20.34913432
131STK110.34904255
132MAP3K130.34572948
133GRK10.33888046
134MAP3K70.33437625
135IRAK20.32398646
136ITK0.31925460
137PRKACA0.30949783
138INSR0.29470737
139PINK10.27872135
140PDK10.27851987
141MAPK70.26984932
142BMPR20.26630860
143DYRK1A0.25371165
144CSNK1E0.25341853
145DDR20.23365254
146SGK10.23190829
147MAPK130.22919452
148BMX0.21869237
149BLK0.20335621
150PRKD20.20264847
151MAPK120.19915789

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.22347201
2Fatty acid elongation_Homo sapiens_hsa000624.93748553
3Steroid biosynthesis_Homo sapiens_hsa001004.34445924
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.45908489
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.15799768
6Nicotine addiction_Homo sapiens_hsa050333.12865417
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.10880404
8Ether lipid metabolism_Homo sapiens_hsa005652.99618537
9Nitrogen metabolism_Homo sapiens_hsa009102.28855984
10Sulfur metabolism_Homo sapiens_hsa009202.24784737
11Vitamin B6 metabolism_Homo sapiens_hsa007502.16161556
12Protein export_Homo sapiens_hsa030601.99751831
13Oxidative phosphorylation_Homo sapiens_hsa001901.96574530
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.91013401
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85483173
16Linoleic acid metabolism_Homo sapiens_hsa005911.84594271
17Insulin secretion_Homo sapiens_hsa049111.75820528
18Sphingolipid metabolism_Homo sapiens_hsa006001.74126308
19Butanoate metabolism_Homo sapiens_hsa006501.71570423
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68927793
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.59844137
22Olfactory transduction_Homo sapiens_hsa047401.54290055
23Calcium signaling pathway_Homo sapiens_hsa040201.45154965
24Parkinsons disease_Homo sapiens_hsa050121.42378327
25Arginine and proline metabolism_Homo sapiens_hsa003301.37939965
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34617414
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32952846
28Caffeine metabolism_Homo sapiens_hsa002321.31855231
29Alzheimers disease_Homo sapiens_hsa050101.31812168
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.29685285
31Propanoate metabolism_Homo sapiens_hsa006401.23834307
32Axon guidance_Homo sapiens_hsa043601.22012017
33* Histidine metabolism_Homo sapiens_hsa003401.20556168
34Amphetamine addiction_Homo sapiens_hsa050311.20505986
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16446461
36Folate biosynthesis_Homo sapiens_hsa007901.13343139
37Selenocompound metabolism_Homo sapiens_hsa004501.10679913
38Fatty acid metabolism_Homo sapiens_hsa012121.07058168
39Circadian rhythm_Homo sapiens_hsa047101.05672443
40Oxytocin signaling pathway_Homo sapiens_hsa049211.05234745
41GABAergic synapse_Homo sapiens_hsa047271.04421393
42Arachidonic acid metabolism_Homo sapiens_hsa005901.04019468
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01589758
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01395464
45Glutathione metabolism_Homo sapiens_hsa004801.00780888
46Serotonergic synapse_Homo sapiens_hsa047260.97575536
47Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95868437
48Glutamatergic synapse_Homo sapiens_hsa047240.93453060
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90342661
50Peroxisome_Homo sapiens_hsa041460.90006257
51cAMP signaling pathway_Homo sapiens_hsa040240.89373125
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85920508
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.84970107
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81653713
55Vitamin digestion and absorption_Homo sapiens_hsa049770.80972137
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80503287
57Renal cell carcinoma_Homo sapiens_hsa052110.78849134
58Collecting duct acid secretion_Homo sapiens_hsa049660.78410764
59Mineral absorption_Homo sapiens_hsa049780.78336991
60Fatty acid degradation_Homo sapiens_hsa000710.78085044
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77966758
62Synaptic vesicle cycle_Homo sapiens_hsa047210.76980076
63Homologous recombination_Homo sapiens_hsa034400.75329402
64Chemical carcinogenesis_Homo sapiens_hsa052040.74167974
65Morphine addiction_Homo sapiens_hsa050320.72998743
66Tight junction_Homo sapiens_hsa045300.71828118
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.71439219
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.70714204
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.70431080
70Fanconi anemia pathway_Homo sapiens_hsa034600.69914088
71Long-term depression_Homo sapiens_hsa047300.69849364
72Cardiac muscle contraction_Homo sapiens_hsa042600.69539216
73Vibrio cholerae infection_Homo sapiens_hsa051100.68830200
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68827546
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68520892
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.66726571
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66081822
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65798341
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65580285
80Autoimmune thyroid disease_Homo sapiens_hsa053200.64765690
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62588774
82Huntingtons disease_Homo sapiens_hsa050160.62410057
83beta-Alanine metabolism_Homo sapiens_hsa004100.62383010
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62108080
85Retinol metabolism_Homo sapiens_hsa008300.60883085
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57895366
87Pyruvate metabolism_Homo sapiens_hsa006200.56976573
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56849127
89Cocaine addiction_Homo sapiens_hsa050300.56833143
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56752323
91Tyrosine metabolism_Homo sapiens_hsa003500.56360557
92Lysosome_Homo sapiens_hsa041420.55043511
93Basal transcription factors_Homo sapiens_hsa030220.54825573
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54606051
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54202580
96Rheumatoid arthritis_Homo sapiens_hsa053230.54163466
97Ovarian steroidogenesis_Homo sapiens_hsa049130.53275794
98* Metabolic pathways_Homo sapiens_hsa011000.53242714
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50535170
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.49777712
101Ras signaling pathway_Homo sapiens_hsa040140.49731760
102Long-term potentiation_Homo sapiens_hsa047200.48810341
103Asthma_Homo sapiens_hsa053100.48143269
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.46514821
105Salivary secretion_Homo sapiens_hsa049700.45919504
106Phototransduction_Homo sapiens_hsa047440.45022449
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43617769
108Endocytosis_Homo sapiens_hsa041440.42444770
109Gastric acid secretion_Homo sapiens_hsa049710.41487161
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39980704
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38899266
112Phagosome_Homo sapiens_hsa041450.38779381
113Circadian entrainment_Homo sapiens_hsa047130.38726996
114Pancreatic secretion_Homo sapiens_hsa049720.38360735
115Dorso-ventral axis formation_Homo sapiens_hsa043200.37388843
116Fatty acid biosynthesis_Homo sapiens_hsa000610.35307128
117Starch and sucrose metabolism_Homo sapiens_hsa005000.34937888
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34543826
119ABC transporters_Homo sapiens_hsa020100.34492747
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33910481
121Glycerolipid metabolism_Homo sapiens_hsa005610.33907026
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.32810330
123Thyroid hormone synthesis_Homo sapiens_hsa049180.32693219
124Type II diabetes mellitus_Homo sapiens_hsa049300.31431412
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30967835
126PPAR signaling pathway_Homo sapiens_hsa033200.28704089
127Hedgehog signaling pathway_Homo sapiens_hsa043400.27614761
128Fat digestion and absorption_Homo sapiens_hsa049750.27575439
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27442469
130Renin secretion_Homo sapiens_hsa049240.26308083
131ErbB signaling pathway_Homo sapiens_hsa040120.25776510
132Bile secretion_Homo sapiens_hsa049760.25346679
133Dopaminergic synapse_Homo sapiens_hsa047280.23137942
134Taste transduction_Homo sapiens_hsa047420.21877313
135Tryptophan metabolism_Homo sapiens_hsa003800.21679733
136ECM-receptor interaction_Homo sapiens_hsa045120.21337016
137Regulation of autophagy_Homo sapiens_hsa041400.21321896
138Cholinergic synapse_Homo sapiens_hsa047250.21276328

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