ASPDH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.75712689
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.75712689
3L-phenylalanine metabolic process (GO:0006558)7.43684691
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.43684691
5aromatic amino acid family catabolic process (GO:0009074)6.97457919
6indole-containing compound catabolic process (GO:0042436)6.30735607
7indolalkylamine catabolic process (GO:0046218)6.30735607
8tryptophan catabolic process (GO:0006569)6.30735607
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.13927192
10epoxygenase P450 pathway (GO:0019373)6.08829999
11glyoxylate metabolic process (GO:0046487)6.07795910
12kynurenine metabolic process (GO:0070189)6.05934512
13tryptophan metabolic process (GO:0006568)5.92673376
14bile acid biosynthetic process (GO:0006699)5.92092820
15omega-hydroxylase P450 pathway (GO:0097267)5.89967370
16urea metabolic process (GO:0019627)5.55997309
17urea cycle (GO:0000050)5.55997309
18cysteine metabolic process (GO:0006534)5.55313520
19alpha-linolenic acid metabolic process (GO:0036109)5.44973240
20high-density lipoprotein particle remodeling (GO:0034375)5.44231099
21sulfur amino acid catabolic process (GO:0000098)5.40306385
22negative regulation of fibrinolysis (GO:0051918)5.39632410
23serine family amino acid catabolic process (GO:0009071)5.28564889
24acrosome reaction (GO:0007340)5.23850569
25peptidyl-glutamic acid carboxylation (GO:0017187)5.21753157
26protein carboxylation (GO:0018214)5.21753157
27regulation of fibrinolysis (GO:0051917)5.20003413
28nitrogen cycle metabolic process (GO:0071941)5.13368604
29aromatic amino acid family metabolic process (GO:0009072)5.07182094
30complement activation, alternative pathway (GO:0006957)5.04561198
31regulation of protein activation cascade (GO:2000257)5.03274232
32bile acid metabolic process (GO:0008206)5.02292995
33sperm motility (GO:0030317)4.99789360
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.99666430
35fusion of sperm to egg plasma membrane (GO:0007342)4.94704919
36lysine catabolic process (GO:0006554)4.92575843
37lysine metabolic process (GO:0006553)4.92575843
38tyrosine metabolic process (GO:0006570)4.85891853
39homocysteine metabolic process (GO:0050667)4.85022785
40regulation of cholesterol esterification (GO:0010872)4.78736830
41alpha-amino acid catabolic process (GO:1901606)4.75349920
42regulation of triglyceride catabolic process (GO:0010896)4.70149261
43reverse cholesterol transport (GO:0043691)4.69402820
44regulation of complement activation (GO:0030449)4.69123351
45amino-acid betaine metabolic process (GO:0006577)4.67515745
46cellular ketone body metabolic process (GO:0046950)4.61739334
47protein-lipid complex remodeling (GO:0034368)4.60789631
48macromolecular complex remodeling (GO:0034367)4.60789631
49plasma lipoprotein particle remodeling (GO:0034369)4.60789631
50negative regulation of cholesterol transport (GO:0032375)4.54340420
51negative regulation of sterol transport (GO:0032372)4.54340420
52triglyceride homeostasis (GO:0070328)4.51555771
53acylglycerol homeostasis (GO:0055090)4.51555771
54response to pheromone (GO:0019236)4.48192600
55indolalkylamine metabolic process (GO:0006586)4.46400940
56phospholipid efflux (GO:0033700)4.43184644
57cellular amino acid catabolic process (GO:0009063)4.40004682
58glutamate metabolic process (GO:0006536)4.38588559
59amine catabolic process (GO:0009310)4.37831563
60cellular biogenic amine catabolic process (GO:0042402)4.37831563
61oxidative demethylation (GO:0070989)4.36663227
62glycine metabolic process (GO:0006544)4.36531392
63ethanol metabolic process (GO:0006067)4.33420455
64serine family amino acid metabolic process (GO:0009069)4.32087972
65drug metabolic process (GO:0017144)4.31439728
66drug catabolic process (GO:0042737)4.28944059
67sperm capacitation (GO:0048240)4.28094607
68cellular modified amino acid catabolic process (GO:0042219)4.28070302
69imidazole-containing compound metabolic process (GO:0052803)4.26510568
70phenylpropanoid metabolic process (GO:0009698)4.26324399
71plasma lipoprotein particle clearance (GO:0034381)4.25195041
72opsonization (GO:0008228)4.24112595
73cellular glucuronidation (GO:0052695)4.22285587
74bile acid and bile salt transport (GO:0015721)4.22094620
75benzene-containing compound metabolic process (GO:0042537)4.20502451
76serine family amino acid biosynthetic process (GO:0009070)4.10332687
77dicarboxylic acid biosynthetic process (GO:0043650)4.07493959
78ethanol oxidation (GO:0006069)4.06712467
79arginine metabolic process (GO:0006525)4.06634959
80cholesterol efflux (GO:0033344)4.05100713
81aldehyde catabolic process (GO:0046185)4.04767039
82glutamate secretion (GO:0014047)4.02442772
83ketone body metabolic process (GO:1902224)3.99883523
84urate metabolic process (GO:0046415)3.91454888
85short-chain fatty acid metabolic process (GO:0046459)3.91151918
86drug transmembrane transport (GO:0006855)3.89407574
87fibrinolysis (GO:0042730)3.87326621
88regulation of plasminogen activation (GO:0010755)3.86813006
89plasma lipoprotein particle assembly (GO:0034377)3.86060464
90acetyl-CoA metabolic process (GO:0006084)3.85310244
91calcium ion-dependent exocytosis (GO:0017156)3.84376963
92organic acid catabolic process (GO:0016054)3.83971437
93carboxylic acid catabolic process (GO:0046395)3.83971437
94exogenous drug catabolic process (GO:0042738)3.83715841
95plasma membrane fusion (GO:0045026)3.83130487
96regulation of bile acid biosynthetic process (GO:0070857)3.80535430
97glucuronate metabolic process (GO:0019585)3.79158047
98uronic acid metabolic process (GO:0006063)3.79158047
99low-density lipoprotein particle remodeling (GO:0034374)3.78590294
100* coenzyme catabolic process (GO:0009109)3.75514081
101negative regulation of lipase activity (GO:0060192)3.70079518
102positive regulation of triglyceride lipase activity (GO:0061365)3.69030352
103positive regulation of lipoprotein lipase activity (GO:0051006)3.69030352
104aspartate family amino acid catabolic process (GO:0009068)3.68035484
105cholesterol homeostasis (GO:0042632)3.66994860
106regulation of cholesterol homeostasis (GO:2000188)3.66588956
107blood coagulation, intrinsic pathway (GO:0007597)3.64274502
108very-low-density lipoprotein particle assembly (GO:0034379)3.62856610
109sterol homeostasis (GO:0055092)3.62036577
110positive regulation of lipid catabolic process (GO:0050996)3.60156854
111complement activation, classical pathway (GO:0006958)3.58260119
112phospholipid homeostasis (GO:0055091)3.58184052
113synaptic vesicle exocytosis (GO:0016079)3.54085565
114flavonoid metabolic process (GO:0009812)3.53866750
115complement activation (GO:0006956)3.53218630
116protein activation cascade (GO:0072376)3.51753111
1172-oxoglutarate metabolic process (GO:0006103)3.51277331
118phosphatidylethanolamine biosynthetic process (GO:0006646)3.49520166
119synaptic vesicle docking involved in exocytosis (GO:0016081)3.48661945
120synaptic vesicle maturation (GO:0016188)3.45397968
121negative regulation of inclusion body assembly (GO:0090084)3.44859308
122regulation of synaptic vesicle exocytosis (GO:2000300)3.44624266
123negative regulation of blood coagulation (GO:0030195)3.37291495
124negative regulation of hemostasis (GO:1900047)3.37291495
125sexual reproduction (GO:0019953)3.31010187
126alkaloid metabolic process (GO:0009820)3.26024434
127phosphatidylethanolamine metabolic process (GO:0046337)3.24399704
128peptidyl-glutamic acid modification (GO:0018200)3.23953150
129chromosome condensation (GO:0030261)3.22950796
130positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.15394616
131steroid catabolic process (GO:0006706)3.12693267
132hormone catabolic process (GO:0042447)3.10821813
133DNA packaging (GO:0006323)3.07709409
134S-adenosylmethionine metabolic process (GO:0046500)3.07127148
135acute-phase response (GO:0006953)3.02903270
136heme transport (GO:0015886)3.02264477
137single strand break repair (GO:0000012)3.00826256
138intestinal cholesterol absorption (GO:0030299)2.99422569
139negative regulation of coagulation (GO:0050819)2.95965744
140negative regulation of wound healing (GO:0061045)2.93678432
141spermatid development (GO:0007286)2.93171583
142iron coordination entity transport (GO:1901678)2.88387695
143regulation of synaptic vesicle transport (GO:1902803)2.87470047

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.35872398
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.14019520
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.83266263
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.43353815
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.26878618
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.94429173
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.81609037
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.97140402
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.91867945
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.53600080
11DROSHA_22980978_ChIP-Seq_HELA_Human2.56692970
12EZH2_22144423_ChIP-Seq_EOC_Human2.31162446
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.10424482
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.09069525
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.02677642
16REST_21632747_ChIP-Seq_MESCs_Mouse2.02552516
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8580455
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97874956
19CTCF_27219007_Chip-Seq_Bcells_Human1.92351176
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80485310
21REST_18959480_ChIP-ChIP_MESCs_Mouse1.80137711
22ELF1_20517297_ChIP-Seq_JURKAT_Human1.80010630
23RARB_27405468_Chip-Seq_BRAIN_Mouse1.79488073
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75722092
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70480377
26* EZH2_27294783_Chip-Seq_ESCs_Mouse1.69821368
27SMC4_20622854_ChIP-Seq_HELA_Human1.68788717
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61848373
29FOXA2_19822575_ChIP-Seq_HepG2_Human1.61791016
30P68_20966046_ChIP-Seq_HELA_Human1.59604690
31CLOCK_20551151_ChIP-Seq_293T_Human1.51075611
32HTT_18923047_ChIP-ChIP_STHdh_Human1.49434044
33E2F1_20622854_ChIP-Seq_HELA_Human1.49037768
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47312140
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43887552
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43103649
37HNF4A_19822575_ChIP-Seq_HepG2_Human1.42813162
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42305365
39CTCF_20526341_ChIP-Seq_ESCs_Human1.40589124
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40496783
41ERA_21632823_ChIP-Seq_H3396_Human1.35131899
42BCL6_27268052_Chip-Seq_Bcells_Human1.34038293
43BCOR_27268052_Chip-Seq_Bcells_Human1.31733369
44GATA1_22025678_ChIP-Seq_K562_Human1.29846534
45RAC3_21632823_ChIP-Seq_H3396_Human1.29813548
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28533264
47PHF8_20622854_ChIP-Seq_HELA_Human1.28028982
48EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.27775968
49EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23613270
50SA1_27219007_Chip-Seq_Bcells_Human1.23148189
51SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23022114
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22819936
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22819936
54MYC_19829295_ChIP-Seq_ESCs_Human1.22589811
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19554368
56RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17628486
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15796270
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14971218
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14971218
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14206426
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14175375
62OCT4_19829295_ChIP-Seq_ESCs_Human1.11411209
63ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10494959
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09866182
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09767169
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06129525
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05977313
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05088613
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.03620135
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02766825
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.02457171
72NANOG_20526341_ChIP-Seq_ESCs_Human1.01930011
73YY1_22570637_ChIP-Seq_MALME-3M_Human1.01914332
74TP63_22573176_ChIP-Seq_HFKS_Human1.01591446
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01060843
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00529171
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99817547
78CBP_20019798_ChIP-Seq_JUKART_Human0.99817547
79WDR5_24793694_ChIP-Seq_LNCAP_Human0.99198707
80SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98653000
81EZH2_27304074_Chip-Seq_ESCs_Mouse0.98448469
82IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98413670
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97757147
84GATA3_21867929_ChIP-Seq_CD8_Mouse0.96446482
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95663271
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94644745
87P300_27268052_Chip-Seq_Bcells_Human0.94410396
88JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.93935545
89KLF4_19829295_ChIP-Seq_ESCs_Human0.93266179
90TET1_21490601_ChIP-Seq_MESCs_Mouse0.92954051
91SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92860118
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92420725
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91692125
94RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91618284
95SOX2_21211035_ChIP-Seq_LN229_Human0.91523802
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91505503
97FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91357540
98EED_16625203_ChIP-ChIP_MESCs_Mouse0.91347342
99ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90950197
100MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90418811
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90370280
102KDM2B_26808549_Chip-Seq_K562_Human0.89762291
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88619781
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85880651
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85844725
106AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83280341
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79748283
108GATA4_25053715_ChIP-Seq_YYC3_Human0.79539034
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76763656
110KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75991872
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74605753
112ESR2_21235772_ChIP-Seq_MCF-7_Human0.72963490
113RARA_24833708_ChIP-Seq_LIVER_Mouse0.71789314
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71544058
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68260016
116IRF8_22096565_ChIP-ChIP_GC-B_Human0.68199541
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.66144285
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65757300
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65355618
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.64993643
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64886322
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64886322
123ZNF263_19887448_ChIP-Seq_K562_Human0.64679374
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64170205
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62469654
126SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62268064
127RARB_24833708_ChIP-Seq_LIVER_Mouse0.62016082
128NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.60578732
129RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.60437519
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.59800930
131LXR_22292898_ChIP-Seq_THP-1_Human0.59379927
132EGR1_19032775_ChIP-ChIP_M12_Human0.58937690
133CEBPB_22108803_ChIP-Seq_LS180_Human0.57764470
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57311348
135MYC_19915707_ChIP-ChIP_AK7_Human0.55909126
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.54814203
137AR_20517297_ChIP-Seq_VCAP_Human0.53724144
138FOXA1_25552417_ChIP-Seq_VCAP_Human0.51961610
139CDX2_20551321_ChIP-Seq_CACO-2_Human0.51959707
140FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51522354
141STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51255741
142CBP_21632823_ChIP-Seq_H3396_Human0.51148229
143ESET_19884257_ChIP-Seq_ESCs_Mouse0.50083770
144GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.47544776
145STAT1_17558387_ChIP-Seq_HELA_Human0.47303128
146PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46841963
147P53_21459846_ChIP-Seq_SAOS-2_Human0.46617706
148ERG_21242973_ChIP-ChIP_JURKAT_Human0.45759300
149* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44439570
150TAF2_19829295_ChIP-Seq_ESCs_Human0.44244099
151FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.43929544
152PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.43862884
153TAF15_26573619_Chip-Seq_HEK293_Human0.43200244
154FOXO3_23340844_ChIP-Seq_DLD1_Human0.42355898
155GATA1_19941827_ChIP-Seq_MEL_Mouse0.42080383
156GATA1_19941826_ChIP-Seq_K562_Human0.41488324
157CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39906100
158PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.39800249
159STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39266491
160MYC_27129775_Chip-Seq_CORNEA_Mouse0.39138880
161OCT4_20526341_ChIP-Seq_ESCs_Human0.38177958
162GATA2_19941826_ChIP-Seq_K562_Human0.37979955
163BCAT_22108803_ChIP-Seq_LS180_Human0.37945598
164NCOR_22424771_ChIP-Seq_293T_Human0.37867572
165SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.37823490
166GATA6_25053715_ChIP-Seq_YYC3_Human0.37630085
167FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.36959521
168P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.36673786
169PPAR_26484153_Chip-Seq_NCI-H1993_Human0.36420967
170LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36415084
171SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36255518
172FOXH1_21741376_ChIP-Seq_EPCs_Human0.36159431
173EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.35822522
174CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.35499426

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.39018633
2MP0005360_urolithiasis7.77109987
3MP0005085_abnormal_gallbladder_physiolo6.33826182
4MP0005365_abnormal_bile_salt6.07690270
5MP0008875_abnormal_xenobiotic_pharmacok5.16183642
6MP0005410_abnormal_fertilization4.85839415
7MP0003806_abnormal_nucleotide_metabolis4.10666526
8MP0003252_abnormal_bile_duct3.88738102
9MP0004859_abnormal_synaptic_plasticity3.69356746
10MP0010329_abnormal_lipoprotein_level3.47925211
11MP0009840_abnormal_foam_cell3.19396723
12MP0003195_calcinosis3.05093377
13MP0005332_abnormal_amino_acid3.01888034
14MP0005083_abnormal_biliary_tract2.93561795
15MP0003880_abnormal_central_pattern2.59835069
16MP0001666_abnormal_nutrient_absorption2.55460183
17MP0005423_abnormal_somatic_nervous2.38657754
18MP0004019_abnormal_vitamin_homeostasis2.36747150
19MP0003191_abnormal_cellular_cholesterol2.27809678
20MP0004270_analgesia2.26462158
21MP0003879_abnormal_hair_cell2.22189211
22MP0003635_abnormal_synaptic_transmissio2.16241150
23MP0002138_abnormal_hepatobiliary_system2.11635000
24MP0002118_abnormal_lipid_homeostasis2.09060728
25MP0000609_abnormal_liver_physiology2.08863329
26MP0002064_seizures2.07656980
27MP0009745_abnormal_behavioral_response2.03350678
28MP0001486_abnormal_startle_reflex1.93680753
29MP0005377_hearing/vestibular/ear_phenot1.93048846
30MP0003878_abnormal_ear_physiology1.93048846
31MP0003868_abnormal_feces_composition1.84815834
32MP0002272_abnormal_nervous_system1.84638009
33MP0001968_abnormal_touch/_nociception1.83204501
34MP0005319_abnormal_enzyme/_coenzyme1.83014273
35MP0001764_abnormal_homeostasis1.67458751
36MP0002063_abnormal_learning/memory/cond1.63987432
37MP0003698_abnormal_male_reproductive1.61969074
38MP0005584_abnormal_enzyme/coenzyme_acti1.61663370
39MP0005451_abnormal_body_composition1.55786884
40MP0002572_abnormal_emotion/affect_behav1.48293544
41MP0009046_muscle_twitch1.45618425
42MP0009697_abnormal_copulation1.43817751
43MP0009643_abnormal_urine_homeostasis1.43394000
44MP0001501_abnormal_sleep_pattern1.39908861
45MP0002735_abnormal_chemical_nociception1.39454157
46MP0001348_abnormal_lacrimal_gland1.36107726
47MP0002734_abnormal_mechanical_nocicepti1.35347075
48MP0008569_lethality_at_weaning1.33162512
49MP0003186_abnormal_redox_activity1.29402035
50MP0003011_delayed_dark_adaptation1.29387830
51MP0002249_abnormal_larynx_morphology1.28799104
52MP0003656_abnormal_erythrocyte_physiolo1.18528671
53MP0001440_abnormal_grooming_behavior1.18167609
54MP0000598_abnormal_liver_morphology1.13554176
55MP0001929_abnormal_gametogenesis1.12890331
56MP0003705_abnormal_hypodermis_morpholog1.11389821
57MP0005636_abnormal_mineral_homeostasis1.09541995
58MP0005647_abnormal_sex_gland1.08647718
59MP0004742_abnormal_vestibular_system1.07624834
60MP0000604_amyloidosis1.06917955
61MP0002132_abnormal_respiratory_system1.05397047
62MP0009764_decreased_sensitivity_to1.04216723
63MP0002733_abnormal_thermal_nociception1.00849301
64MP0001970_abnormal_pain_threshold1.00553872
65MP0003633_abnormal_nervous_system1.00495801
66MP0002067_abnormal_sensory_capabilities0.99803458
67MP0002736_abnormal_nociception_after0.98138773
68MP0002161_abnormal_fertility/fecundity0.98084218
69MP0002557_abnormal_social/conspecific_i0.97120742
70MP0009763_increased_sensitivity_to0.94710601
71MP0003631_nervous_system_phenotype0.94405418
72MP0001905_abnormal_dopamine_level0.92885692
73MP0000678_abnormal_parathyroid_gland0.92810843
74MP0010386_abnormal_urinary_bladder0.91125106
75MP0000920_abnormal_myelination0.88681945
76MP0001986_abnormal_taste_sensitivity0.88168422
77MP0009642_abnormal_blood_homeostasis0.88000664
78MP0001502_abnormal_circadian_rhythm0.86891864
79MP0010368_abnormal_lymphatic_system0.86740909
80MP0002254_reproductive_system_inflammat0.86596810
81MP0006036_abnormal_mitochondrial_physio0.86477773
82MP0008469_abnormal_protein_level0.85763308
83MP0002876_abnormal_thyroid_physiology0.83667461
84MP0002229_neurodegeneration0.83620761
85MP0005408_hypopigmentation0.83323422
86MP0005670_abnormal_white_adipose0.82846183
87MP0005084_abnormal_gallbladder_morpholo0.82122732
88MP0004811_abnormal_neuron_physiology0.81398192
89MP0001963_abnormal_hearing_physiology0.81249970
90MP0004510_myositis0.79608489
91MP0003632_abnormal_nervous_system0.78789025
92MP0002078_abnormal_glucose_homeostasis0.77020680
93MP0005376_homeostasis/metabolism_phenot0.76832563
94MP0001984_abnormal_olfaction0.76678292
95MP0009765_abnormal_xenobiotic_induced0.76181833
96MP0002066_abnormal_motor_capabilities/c0.75806736
97MP0001485_abnormal_pinna_reflex0.75653440
98MP0001756_abnormal_urination0.74846222
99MP0000955_abnormal_spinal_cord0.74076936
100MP0005551_abnormal_eye_electrophysiolog0.73802211
101MP0003329_amyloid_beta_deposits0.72322062
102MP0005535_abnormal_body_temperature0.71261261
103MP0002971_abnormal_brown_adipose0.70709223
104MP0003690_abnormal_glial_cell0.70302343
105MP0005220_abnormal_exocrine_pancreas0.70097170
106MP0001661_extended_life_span0.69553334
107MP0003172_abnormal_lysosome_physiology0.69529526
108MP0009780_abnormal_chondrocyte_physiolo0.68246509
109MP0005386_behavior/neurological_phenoty0.67598767
110MP0004924_abnormal_behavior0.67598767
111MP0005334_abnormal_fat_pad0.66913370
112MP0002282_abnormal_trachea_morphology0.66073216
113MP0005167_abnormal_blood-brain_barrier0.64288814
114MP0004130_abnormal_muscle_cell0.64220148
115MP0006276_abnormal_autonomic_nervous0.62591751
116MP0005646_abnormal_pituitary_gland0.62396736
117MP0005266_abnormal_metabolism0.61991353
118MP0009053_abnormal_anal_canal0.61353407
119MP0002136_abnormal_kidney_physiology0.60409221
120MP0002882_abnormal_neuron_morphology0.57990405
121MP0006035_abnormal_mitochondrial_morpho0.57221677
122MP0000639_abnormal_adrenal_gland0.54786305
123MP0004043_abnormal_pH_regulation0.52241063
124MP0005448_abnormal_energy_balance0.51067346
125MP0002822_catalepsy0.50683059
126MP0005395_other_phenotype0.50578092
127MP0003638_abnormal_response/metabolism_0.48620241
128MP0002928_abnormal_bile_duct0.48086670
129MP0008874_decreased_physiological_sensi0.46575484
130MP0003718_maternal_effect0.44311291
131MP0005666_abnormal_adipose_tissue0.42543607
132MP0003953_abnormal_hormone_level0.42336168
133MP0005464_abnormal_platelet_physiology0.41677913
134MP0008873_increased_physiological_sensi0.41293176
135MP0002837_dystrophic_cardiac_calcinosis0.40370777
136MP0008872_abnormal_physiological_respon0.38512703
137MP0003724_increased_susceptibility_to0.38279934
138MP0003075_altered_response_to0.38204135
139MP0001765_abnormal_ion_homeostasis0.37819451
140MP0000230_abnormal_systemic_arterial0.37620574
141MP0009672_abnormal_birth_weight0.37205187
142MP0002168_other_aberrant_phenotype0.36771034
143MP0004782_abnormal_surfactant_physiolog0.36117210
144MP0005166_decreased_susceptibility_to0.35735816
145MP0004381_abnormal_hair_follicle0.35024217
146MP0005058_abnormal_lysosome_morphology0.34722171
147MP0002796_impaired_skin_barrier0.33965298
148MP0005248_abnormal_Harderian_gland0.33738244
149MP0000579_abnormal_nail_morphology0.30776196
150MP0003436_decreased_susceptibility_to0.30147655
151MP0009384_cardiac_valve_regurgitation0.30027021
152MP0009115_abnormal_fat_cell0.28695600
153MP0002970_abnormal_white_adipose0.27512875
154MP0006082_CNS_inflammation0.27501685
155MP0000249_abnormal_blood_vessel0.27358940
156MP0001243_abnormal_dermal_layer0.26435515
157MP0002135_abnormal_kidney_morphology0.25209983
158MP0002090_abnormal_vision0.24907048
159MP0004883_abnormal_blood_vessel0.23627892
160MP0001845_abnormal_inflammatory_respons0.23472457
161MP0000538_abnormal_urinary_bladder0.23269733

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.48445287
2Intrahepatic cholestasis (HP:0001406)7.07302471
3Deep venous thrombosis (HP:0002625)7.06365441
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.54941267
5Prolonged partial thromboplastin time (HP:0003645)6.23035973
6Xanthomatosis (HP:0000991)6.13153266
7Hypobetalipoproteinemia (HP:0003563)6.04325454
8Hyperlipoproteinemia (HP:0010980)5.46769554
9Complement deficiency (HP:0004431)4.98233295
10Hyperammonemia (HP:0001987)4.65765559
11Myokymia (HP:0002411)4.64814116
12Joint hemorrhage (HP:0005261)4.62170198
13Hypolipoproteinemia (HP:0010981)4.54215689
14Hyperglycinemia (HP:0002154)4.50537907
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.48673355
16Ketosis (HP:0001946)4.44970439
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.32266159
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.27383566
19Epidermoid cyst (HP:0200040)4.25543569
20Hyperglycinuria (HP:0003108)4.22679882
21Abnormality of methionine metabolism (HP:0010901)4.22234553
22Abnormality of the common coagulation pathway (HP:0010990)4.15368406
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.15171450
24Abnormality of serine family amino acid metabolism (HP:0010894)4.14650533
25Abnormality of glycine metabolism (HP:0010895)4.14650533
26Hypoalphalipoproteinemia (HP:0003233)4.03301705
27Fat malabsorption (HP:0002630)3.93204412
28Abnormality of pyrimidine metabolism (HP:0004353)3.79962261
29Hypoglycemic coma (HP:0001325)3.79119957
30Abnormality of complement system (HP:0005339)3.60169631
31Abnormality of the intrinsic pathway (HP:0010989)3.54644024
32Conjugated hyperbilirubinemia (HP:0002908)3.50610565
33Abnormality of fatty-acid metabolism (HP:0004359)3.45975847
34Hypercholesterolemia (HP:0003124)3.38841641
35Severe visual impairment (HP:0001141)3.34409397
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.33826085
37Abnormality of nucleobase metabolism (HP:0010932)3.29295387
38Delayed CNS myelination (HP:0002188)3.28918867
39Ketoacidosis (HP:0001993)3.26231930
40Hyperbilirubinemia (HP:0002904)3.25869530
41Abnormality of serum amino acid levels (HP:0003112)3.13032222
42Focal motor seizures (HP:0011153)3.09843413
43Atonic seizures (HP:0010819)3.08260027
44Gout (HP:0001997)3.07598264
45Action tremor (HP:0002345)3.05318906
46Abnormality of purine metabolism (HP:0004352)3.03961950
47Epileptic encephalopathy (HP:0200134)3.00689031
48Steatorrhea (HP:0002570)2.98204569
49Hepatocellular carcinoma (HP:0001402)2.95897993
50Progressive cerebellar ataxia (HP:0002073)2.89529625
51Metabolic acidosis (HP:0001942)2.88590566
52Febrile seizures (HP:0002373)2.86794066
53Spontaneous abortion (HP:0005268)2.84234473
54Vascular calcification (HP:0004934)2.81249437
55Myocardial infarction (HP:0001658)2.80389025
56Focal seizures (HP:0007359)2.80185722
57Amblyopia (HP:0000646)2.73890625
58Dicarboxylic aciduria (HP:0003215)2.73108644
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.73108644
60Hypochromic microcytic anemia (HP:0004840)2.73097631
61Lethargy (HP:0001254)2.72712392
62Facial shape deformation (HP:0011334)2.69778294
63Potter facies (HP:0002009)2.69778294
64Postural instability (HP:0002172)2.64872503
65Skin nodule (HP:0200036)2.60857817
66Systemic lupus erythematosus (HP:0002725)2.60665943
67Osteomalacia (HP:0002749)2.59596030
68Nephritis (HP:0000123)2.52320153
69Cerebral edema (HP:0002181)2.50278824
70Spastic diplegia (HP:0001264)2.49147208
71Cardiovascular calcification (HP:0011915)2.48695911
72Atrioventricular block (HP:0001678)2.48348587
73Resting tremor (HP:0002322)2.48207037
74Irritability (HP:0000737)2.46832502
75Neonatal onset (HP:0003623)2.44570845
76Mitral stenosis (HP:0001718)2.43918572
77Hypoglycemic seizures (HP:0002173)2.40764141
78Generalized aminoaciduria (HP:0002909)2.37373732
79Abnormal gallbladder morphology (HP:0012437)2.37337399
80Attenuation of retinal blood vessels (HP:0007843)2.36316534
81Malnutrition (HP:0004395)2.35728992
82Asymmetric septal hypertrophy (HP:0001670)2.32807567
83Cholelithiasis (HP:0001081)2.30953408
84Enlarged kidneys (HP:0000105)2.26683429
85Acanthocytosis (HP:0001927)2.25182448
86Abnormal gallbladder physiology (HP:0012438)2.24446744
87Cholecystitis (HP:0001082)2.24446744
88Vomiting (HP:0002013)2.23908020
89Alkalosis (HP:0001948)2.23843263
90Bony spicule pigmentary retinopathy (HP:0007737)2.23509383
91Glomerulonephritis (HP:0000099)2.22656343
92Sensorimotor neuropathy (HP:0007141)2.22144648
93Amyloidosis (HP:0011034)2.21951383
94Delusions (HP:0000746)2.20822380
95Late onset (HP:0003584)2.20729475
96Rickets (HP:0002748)2.14609584
97Hydroxyprolinuria (HP:0003080)2.14379989
98Abnormality of proline metabolism (HP:0010907)2.14379989
99Brushfield spots (HP:0001088)2.13944911
100Pancreatitis (HP:0001733)2.13783209
101Proximal tubulopathy (HP:0000114)2.13622073
102Dysmetria (HP:0001310)2.12213665
103Hyperuricemia (HP:0002149)2.12185134
104Increased purine levels (HP:0004368)2.12185134
105Absence seizures (HP:0002121)2.11574725
106Recurrent gram-negative bacterial infections (HP:0005420)2.11071318
107Hyperphosphaturia (HP:0003109)2.09493748
108Opisthotonus (HP:0002179)2.05919231
109Esophageal varix (HP:0002040)2.05342961
110Thrombophlebitis (HP:0004418)2.01742226
111Hypophosphatemic rickets (HP:0004912)2.01537249
112Retinal atrophy (HP:0001105)2.01060702
113Menorrhagia (HP:0000132)2.00299155
114Gingival bleeding (HP:0000225)1.99584974
115Abnormality of the gallbladder (HP:0005264)1.97726087
116Intention tremor (HP:0002080)1.97652595
117Hemorrhage of the eye (HP:0011885)1.96569358
118Abnormal enzyme/coenzyme activity (HP:0012379)1.95313291
119Hyperinsulinemic hypoglycemia (HP:0000825)1.93740397
120Abnormality of urine glucose concentration (HP:0011016)1.91216371
121Glycosuria (HP:0003076)1.91216371
122Neonatal hypoglycemia (HP:0001998)1.90969755
123Torticollis (HP:0000473)1.88936840
124Abnormal cartilage morphology (HP:0002763)1.88343828
125Heart block (HP:0012722)1.88248085
126Azoospermia (HP:0000027)1.87792690
127Widely patent fontanelles and sutures (HP:0004492)1.86173457
128Status epilepticus (HP:0002133)1.84915256
129Epileptiform EEG discharges (HP:0011182)1.84903778
130Abnormal urine output (HP:0012590)1.84226708
131Enlarged epiphyses (HP:0010580)1.83671916
132Abnormality of transition element cation homeostasis (HP:0011030)1.83324969
133Abnormality of iron homeostasis (HP:0011031)1.82205570
134Poikilocytosis (HP:0004447)1.81601684
135Ankle clonus (HP:0011448)1.80593803
136Dialeptic seizures (HP:0011146)1.80315964
137Abnormal urine phosphate concentration (HP:0012599)1.80122675
138Bell-shaped thorax (HP:0001591)1.78107138
139Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.76821935
140Focal dystonia (HP:0004373)1.76090049
141Depression (HP:0000716)1.72252757
142Abnormality of the Achilles tendon (HP:0005109)1.71601764
143EEG with generalized epileptiform discharges (HP:0011198)1.70900630
144Abnormal eating behavior (HP:0100738)1.68980200
145Bradykinesia (HP:0002067)1.67982825
146Abnormal atrioventricular conduction (HP:0005150)1.66866156
147Decreased central vision (HP:0007663)1.66301689
148Spastic paraparesis (HP:0002313)1.66135821

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.55904149
2FGFR44.62567142
3TESK14.42273156
4SIK14.40305528
5ERN14.21225363
6NTRK33.32413864
7PLK43.26856766
8INSRR2.87719809
9DDR22.85072495
10TAOK32.79805797
11ERBB42.79638832
12STK382.67101030
13PLK22.66571480
14UHMK12.59715702
15PAK62.54260704
16PRKD32.50844961
17MAP3K92.30841837
18MAP2K42.30567039
19MST1R2.07149170
20PKN21.98266814
21MAP4K21.97315286
22MARK11.91797421
23MAPK111.81346582
24GRK51.75457581
25KSR21.75108353
26FLT31.64055156
27ARAF1.61730269
28TRIB31.60126981
29DAPK21.57979609
30CAMKK11.56510149
31PIK3CG1.55610664
32ABL21.50741003
33MINK11.45623563
34RIPK41.45064086
35TYK21.44602318
36LATS11.42959923
37PTK61.40873323
38PRPF4B1.35784550
39PINK11.30150907
40EPHB11.26996314
41WNK11.26666340
42FGFR21.25376999
43SIK21.20188496
44STK38L1.18399254
45CAMK11.18092909
46LATS21.17463663
47MAP3K71.17110555
48WNK41.14596850
49JAK21.14553440
50GRK61.14504813
51KDR1.11646490
52CAMK1G1.11256109
53NEK61.10737719
54PRKAA21.10231239
55NEK91.09787666
56MARK21.09412974
57CDK51.04819297
58MAPK151.03040653
59PRKCZ0.98747548
60FRK0.98601387
61ERBB20.98387849
62TBK10.98105100
63MAP3K40.96895447
64NTRK20.95486371
65MET0.93939374
66MAPK40.93354417
67OXSR10.92615622
68MAP2K30.90876654
69TNK20.88137805
70WNK30.86928964
71MAP3K140.85564044
72PRKG10.85036376
73JAK10.82530122
74MAPK120.82068488
75PRKG20.81695899
76MAP3K20.80077098
77DYRK1B0.79757518
78GSK3A0.78864383
79SGK10.77918789
80PRKACG0.76920168
81TIE10.76687166
82EPHA40.76570538
83MAP3K30.75116168
84CAMK2G0.74156266
85SGK30.73982468
86CSK0.73834625
87PRKCH0.73530609
88CAMK2A0.73425901
89MAP3K100.73273075
90CAMK2B0.72468686
91MAP3K110.72250626
92SGK2230.70660019
93SGK4940.70660019
94CDK11A0.70062109
95BRAF0.70055043
96MAP3K10.69570433
97PRKAA10.69196199
98DAPK10.68987575
99PTK20.67543944
100MAPK100.66819477
101IRAK30.64952348
102MAP2K60.64663769
103PDPK10.61967410
104CDK60.61865619
105EPHA30.61722136
106PNCK0.60239124
107CSNK1G10.59616283
108SGK20.59360010
109CDK140.57782693
110PRKCQ0.57377343
111BRD40.57299071
112CDK150.55987660
113MAP2K70.55894071
114RPS6KA30.55440458
115CAMKK20.55059156
116MAPK70.53885484
117CASK0.53790748
118ICK0.53736869
119CAMK1D0.53552517
120PKN10.52203799
121CDK180.50546613
122DYRK1A0.50525134
123PBK0.49154963
124PTK2B0.47650227
125TAOK20.47624575
126PRKACA0.47516370
127STK110.47410149
128IKBKE0.47397977
129PRKCG0.47129314
130NTRK10.46424252
131TGFBR20.46094121
132MAPK80.45484048
133GSK3B0.44920136
134PRKCB0.44752511
135PHKG20.44183446
136PHKG10.44183446
137MAP3K130.43188175
138CSF1R0.42327516
139PDK40.41794416
140PDK30.41794416
141IRAK20.41464970
142RIPK10.40832837
143CSNK1G20.40556111
144MAP2K10.40548518
145CSNK1G30.40429915
146RPS6KA20.39878855
147TYRO30.39823392
148IGF1R0.39511115
149MAPK130.36891116
150MAP3K120.36481218
151RET0.36426194
152GRK10.36102911
153PDK10.35992532
154CAMK40.34641264
155PAK30.34055688
156IRAK10.33748396
157MAP3K50.33335731
158FGFR30.32873689
159STK390.31625409
160MTOR0.31186848
161CSNK1A1L0.30820884
162MAP3K60.30142281
163EGFR0.28402594
164PRKCA0.28070922
165CDK40.25126316

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.41992883
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.39766999
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.36391796
4Nitrogen metabolism_Homo sapiens_hsa009103.34400993
5Arginine biosynthesis_Homo sapiens_hsa002203.02332473
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.70423006
7Tryptophan metabolism_Homo sapiens_hsa003802.70021253
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69171918
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58792560
10Complement and coagulation cascades_Homo sapiens_hsa046102.58673841
11Fatty acid degradation_Homo sapiens_hsa000712.48448078
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46069193
13Butanoate metabolism_Homo sapiens_hsa006502.33398104
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.31506389
15Peroxisome_Homo sapiens_hsa041462.15913690
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08936195
17Propanoate metabolism_Homo sapiens_hsa006402.00011932
18Histidine metabolism_Homo sapiens_hsa003401.91378131
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.89954905
20Chemical carcinogenesis_Homo sapiens_hsa052041.89275192
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86195053
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85275165
23PPAR signaling pathway_Homo sapiens_hsa033201.84989777
24Fatty acid metabolism_Homo sapiens_hsa012121.81958175
25beta-Alanine metabolism_Homo sapiens_hsa004101.74191344
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73384651
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.71376456
28Retinol metabolism_Homo sapiens_hsa008301.64901757
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62944989
30Caffeine metabolism_Homo sapiens_hsa002321.62795443
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61834912
32Staphylococcus aureus infection_Homo sapiens_hsa051501.60607191
33Phenylalanine metabolism_Homo sapiens_hsa003601.57235888
34Selenocompound metabolism_Homo sapiens_hsa004501.54531200
35Bile secretion_Homo sapiens_hsa049761.51572514
36Pyruvate metabolism_Homo sapiens_hsa006201.46464804
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44604048
38Sulfur metabolism_Homo sapiens_hsa009201.43020332
39Tyrosine metabolism_Homo sapiens_hsa003501.41256972
40Fatty acid elongation_Homo sapiens_hsa000621.34961941
41Synaptic vesicle cycle_Homo sapiens_hsa047211.33804541
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.31322982
43Steroid biosynthesis_Homo sapiens_hsa001001.28051344
44Starch and sucrose metabolism_Homo sapiens_hsa005001.26921159
45Nicotine addiction_Homo sapiens_hsa050331.26884972
46Folate biosynthesis_Homo sapiens_hsa007901.25449880
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.21328920
48Biosynthesis of amino acids_Homo sapiens_hsa012301.20463015
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19105107
50Carbon metabolism_Homo sapiens_hsa012001.15559553
51ABC transporters_Homo sapiens_hsa020101.12060770
52Fat digestion and absorption_Homo sapiens_hsa049751.07952307
53Arginine and proline metabolism_Homo sapiens_hsa003301.03938636
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01083295
55GABAergic synapse_Homo sapiens_hsa047271.00851856
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.99392425
57Sulfur relay system_Homo sapiens_hsa041220.94945108
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94860936
59Vitamin digestion and absorption_Homo sapiens_hsa049770.90875319
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87856134
61Vitamin B6 metabolism_Homo sapiens_hsa007500.86918649
62Glutamatergic synapse_Homo sapiens_hsa047240.84495393
63Lysine degradation_Homo sapiens_hsa003100.84256305
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84230423
65Circadian entrainment_Homo sapiens_hsa047130.79434613
66Morphine addiction_Homo sapiens_hsa050320.77636299
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75788638
68Insulin secretion_Homo sapiens_hsa049110.75239116
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72244128
70Amphetamine addiction_Homo sapiens_hsa050310.71393243
71Glutathione metabolism_Homo sapiens_hsa004800.70485325
72Long-term potentiation_Homo sapiens_hsa047200.70411772
73Glycerolipid metabolism_Homo sapiens_hsa005610.68738114
74One carbon pool by folate_Homo sapiens_hsa006700.68407705
75Olfactory transduction_Homo sapiens_hsa047400.63389417
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58626138
77Serotonergic synapse_Homo sapiens_hsa047260.57505586
78Pentose phosphate pathway_Homo sapiens_hsa000300.55320154
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55223210
80Cocaine addiction_Homo sapiens_hsa050300.54027170
81Metabolic pathways_Homo sapiens_hsa011000.48239303
82Type II diabetes mellitus_Homo sapiens_hsa049300.46670205
83Fatty acid biosynthesis_Homo sapiens_hsa000610.45277365
84Taste transduction_Homo sapiens_hsa047420.44683160
85Salivary secretion_Homo sapiens_hsa049700.44386608
86Gastric acid secretion_Homo sapiens_hsa049710.43762372
87Dopaminergic synapse_Homo sapiens_hsa047280.43334427
88Cholinergic synapse_Homo sapiens_hsa047250.37706317
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34517295
90Prion diseases_Homo sapiens_hsa050200.31799364
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30622085
92Calcium signaling pathway_Homo sapiens_hsa040200.30459195
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28904618
94Renin secretion_Homo sapiens_hsa049240.28515190
95Fructose and mannose metabolism_Homo sapiens_hsa000510.27126171
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25421758
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23138561
98cAMP signaling pathway_Homo sapiens_hsa040240.22830848
99Galactose metabolism_Homo sapiens_hsa000520.22430056
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22401905
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.21237592
102Insulin resistance_Homo sapiens_hsa049310.20904706
103Linoleic acid metabolism_Homo sapiens_hsa005910.19938824
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19628636
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.19315617
106Long-term depression_Homo sapiens_hsa047300.15972616
107Oxytocin signaling pathway_Homo sapiens_hsa049210.14669321
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.14506602
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.14485296
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.13091393
111Glucagon signaling pathway_Homo sapiens_hsa049220.07981168
112AMPK signaling pathway_Homo sapiens_hsa041520.01895472
113Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2445032
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2429759
115Protein digestion and absorption_Homo sapiens_hsa04974-0.2358505
116Mineral absorption_Homo sapiens_hsa04978-0.2300943
117Ether lipid metabolism_Homo sapiens_hsa00565-0.2088996
118Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1980124
119Hepatitis C_Homo sapiens_hsa05160-0.1901035
120African trypanosomiasis_Homo sapiens_hsa05143-0.1833638
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1810155
122Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1749390
123Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1711122
124Renin-angiotensin system_Homo sapiens_hsa04614-0.1696720
125Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1572650
126Regulation of autophagy_Homo sapiens_hsa04140-0.1375730
127Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1263476
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1241037
129Insulin signaling pathway_Homo sapiens_hsa04910-0.1222589
130Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1208819
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1089400
132Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0750052
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0083467

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