ASPH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)5.51577644
2plasma membrane repair (GO:0001778)4.65626095
3COPI coating of Golgi vesicle (GO:0048205)4.65306273
4Golgi transport vesicle coating (GO:0048200)4.65306273
5cardiac myofibril assembly (GO:0055003)4.54166619
6skin morphogenesis (GO:0043589)4.46779015
7* positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.31168610
8cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.30120752
9* regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.26648074
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.21334191
11* regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.11245818
12protein retention in ER lumen (GO:0006621)4.08886868
13hemidesmosome assembly (GO:0031581)4.04378023
14* regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.95178443
15myofibril assembly (GO:0030239)3.93483164
16cell communication by electrical coupling (GO:0010644)3.86932568
17retina vasculature morphogenesis in camera-type eye (GO:0061299)3.78794786
18sarcomere organization (GO:0045214)3.76877429
19endothelial cell morphogenesis (GO:0001886)3.76161647
20negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.64486220
21cellular response to vitamin (GO:0071295)3.61167930
22regulation of skeletal muscle contraction (GO:0014819)3.60845236
23daunorubicin metabolic process (GO:0044597)3.60620137
24polyketide metabolic process (GO:0030638)3.60620137
25doxorubicin metabolic process (GO:0044598)3.60620137
26sarcoplasmic reticulum calcium ion transport (GO:0070296)3.59678405
27relaxation of cardiac muscle (GO:0055119)3.53197729
28protein localization to endosome (GO:0036010)3.48967587
29muscle cell migration (GO:0014812)3.48876977
30endodermal cell differentiation (GO:0035987)3.43679004
31low-density lipoprotein particle clearance (GO:0034383)3.43360850
32mesenchymal-epithelial cell signaling (GO:0060638)3.43067259
33cardiac muscle contraction (GO:0060048)3.42743750
34* regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.40030328
35cell communication involved in cardiac conduction (GO:0086065)3.37837983
36positive regulation of osteoblast proliferation (GO:0033690)3.36822324
37negative regulation of potassium ion transmembrane transport (GO:1901380)3.34455938
38cellular response to vitamin D (GO:0071305)3.33267854
39actin-myosin filament sliding (GO:0033275)3.32057011
40muscle filament sliding (GO:0030049)3.32057011
41mesodermal cell differentiation (GO:0048333)3.30955234
42cell-substrate junction assembly (GO:0007044)3.27394405
43regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.27258121
44COPII vesicle coating (GO:0048208)3.26317593
45regulation of transforming growth factor beta2 production (GO:0032909)3.24867408
46desmosome organization (GO:0002934)3.19433263
47peptidyl-proline hydroxylation (GO:0019511)3.18666554
48regulation of membrane repolarization (GO:0060306)3.17265214
49substrate-dependent cell migration (GO:0006929)3.16097992
50aminoglycoside antibiotic metabolic process (GO:0030647)3.13712328
51sodium ion export (GO:0071436)3.11695694
52membrane raft organization (GO:0031579)3.08751183
53regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.08306492
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.06469749
55regulation of sarcomere organization (GO:0060297)3.05958440
56hypotonic response (GO:0006971)3.05349061
57lung vasculature development (GO:0060426)3.04588659
58positive regulation of endothelial cell apoptotic process (GO:2000353)3.04189493
59carnitine shuttle (GO:0006853)3.03764135
60cellular potassium ion homeostasis (GO:0030007)3.02668737
61protein heterotrimerization (GO:0070208)3.02382209
62insulin-like growth factor receptor signaling pathway (GO:0048009)2.98622461
63regulation of actin filament-based movement (GO:1903115)2.98339371
64* regulation of cell communication by electrical coupling (GO:0010649)2.97655713
65regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.96676733
66regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.96647266
67cardiac muscle hypertrophy (GO:0003300)2.95692328
68chondrocyte proliferation (GO:0035988)2.95680334
69basement membrane organization (GO:0071711)2.92009760
70actomyosin structure organization (GO:0031032)2.91609919
71vesicle coating (GO:0006901)2.91115337
72regulation of relaxation of muscle (GO:1901077)2.89039806
73barbed-end actin filament capping (GO:0051016)2.86933301
74striated muscle hypertrophy (GO:0014897)2.86506944
75actin-mediated cell contraction (GO:0070252)2.84751127
76tricarboxylic acid cycle (GO:0006099)2.84506324
77positive regulation of extracellular matrix organization (GO:1903055)2.84163387
78* positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.83304217
79fatty acid transmembrane transport (GO:1902001)2.83001811
80protein localization to cell surface (GO:0034394)2.79552234
81cardiac muscle cell development (GO:0055013)2.79513395
82membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.78116391
83dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.77801661
84negative regulation of anoikis (GO:2000811)2.77723582
85ventricular cardiac muscle cell action potential (GO:0086005)2.76637265
86regulation of acyl-CoA biosynthetic process (GO:0050812)2.75733064
87potassium ion import (GO:0010107)2.72839959
88retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.72484634
89establishment of nucleus localization (GO:0040023)2.72215055
90epithelial cell-cell adhesion (GO:0090136)2.70798288
91striated muscle contraction (GO:0006941)2.70187374
92positive regulation of fatty acid oxidation (GO:0046321)2.69638335
93cardiac conduction (GO:0061337)2.68697851
94regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.68081964
95type B pancreatic cell proliferation (GO:0044342)2.67822831
96* protein hydroxylation (GO:0018126)2.66819097
97kidney mesenchyme development (GO:0072074)2.66697459
98substrate adhesion-dependent cell spreading (GO:0034446)2.66683497
99regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.66681077
100positive regulation of fatty acid beta-oxidation (GO:0032000)2.65749467
101iron ion import (GO:0097286)2.64414216
102positive regulation of muscle hypertrophy (GO:0014742)2.63592618
103positive regulation of cardiac muscle hypertrophy (GO:0010613)2.63592618
104negative regulation of fatty acid transport (GO:2000192)2.63502141
105relaxation of muscle (GO:0090075)2.62988205
106cardiac cell development (GO:0055006)2.62748483
107regulation of sequestering of triglyceride (GO:0010889)2.62089186
108activation of protein kinase A activity (GO:0034199)2.62074792
109axon extension involved in axon guidance (GO:0048846)2.60926129
110neuron projection extension involved in neuron projection guidance (GO:1902284)2.60926129
111* regulation of calcium ion transmembrane transport (GO:1903169)2.60361746
112* regulation of calcium ion transmembrane transporter activity (GO:1901019)2.60361746
113regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.59962613
114* regulation of striated muscle contraction (GO:0006942)2.58851516
115regulation of cofactor metabolic process (GO:0051193)2.58366214
116regulation of coenzyme metabolic process (GO:0051196)2.58366214
117negative regulation of protein localization to plasma membrane (GO:1903077)2.57635331
118sequestering of extracellular ligand from receptor (GO:0035581)2.57521752
119regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.57448193
120cell-substrate adherens junction assembly (GO:0007045)2.55160343
121focal adhesion assembly (GO:0048041)2.55160343
122actin filament depolymerization (GO:0030042)2.55052338
123UDP-N-acetylglucosamine metabolic process (GO:0006047)2.54062823
124negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.52853824
125adherens junction assembly (GO:0034333)2.51882215
126positive regulation of potassium ion transmembrane transport (GO:1901381)2.51866374
127regulation of osteoblast proliferation (GO:0033688)2.51303345
128paraxial mesoderm development (GO:0048339)2.51127406
129cytoskeletal anchoring at plasma membrane (GO:0007016)2.51025099
130regulation of the force of heart contraction (GO:0002026)2.50922281
131stress fiber assembly (GO:0043149)2.50625698
132actin filament-based movement (GO:0030048)2.49696779
133membrane repolarization during action potential (GO:0086011)2.49471012
134protein maturation by protein folding (GO:0022417)2.49343442
135cell migration involved in sprouting angiogenesis (GO:0002042)2.49281783
136muscle hypertrophy (GO:0014896)2.47859067
137positive regulation of glycogen biosynthetic process (GO:0045725)2.47478636
138regulation of glucose import in response to insulin stimulus (GO:2001273)2.46196911
139membrane protein ectodomain proteolysis (GO:0006509)2.45898259
140regulation of extracellular matrix disassembly (GO:0010715)2.45307391
141nucleus localization (GO:0051647)2.45244335
142regulation of integrin-mediated signaling pathway (GO:2001044)2.45167860
143positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.45121417
144cardiac muscle cell action potential (GO:0086001)2.44921826
145negative regulation of chondrocyte differentiation (GO:0032331)2.43820575
146regulation of metalloenzyme activity (GO:0048552)2.43732454
147regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.42571281
148cardiac muscle cell action potential involved in contraction (GO:0086002)2.42361725
149cardiac muscle adaptation (GO:0014887)2.42084086
150cardiac muscle hypertrophy in response to stress (GO:0014898)2.42084086
151muscle hypertrophy in response to stress (GO:0003299)2.42084086
152apoptotic cell clearance (GO:0043277)2.41812620
153regulation of fatty acid oxidation (GO:0046320)2.40280207
154regulation of heart rate by cardiac conduction (GO:0086091)2.39649211
155cellular sodium ion homeostasis (GO:0006883)2.38307044
156collagen metabolic process (GO:0032963)2.38302697
157adult heart development (GO:0007512)2.38131166
158vascular endothelial growth factor signaling pathway (GO:0038084)2.37534618
159regulation of cardiac muscle cell contraction (GO:0086004)2.37394144
160positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.35296032
161response to pheromone (GO:0019236)2.34205344
162glycogen catabolic process (GO:0005980)2.34142864
163extracellular matrix assembly (GO:0085029)2.33344025
164growth hormone secretion (GO:0030252)2.32993757
165glomerular basement membrane development (GO:0032836)2.31309120
166glomerular visceral epithelial cell development (GO:0072015)2.31198557
167retinal metabolic process (GO:0042574)2.31092018
168collagen fibril organization (GO:0030199)2.30734499
169regulation of anoikis (GO:2000209)2.30463298
170* regulation of cardiac muscle contraction (GO:0055117)2.30200949
171fatty acid homeostasis (GO:0055089)2.30039086
172positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.29864234
173multicellular organismal macromolecule metabolic process (GO:0044259)2.29378883
174membrane repolarization (GO:0086009)2.29161737
175negative regulation of protein activation cascade (GO:2000258)2.28913835
176protein targeting to Golgi (GO:0000042)2.28795147
177locomotory exploration behavior (GO:0035641)2.28735210
178negative regulation of complement activation (GO:0045916)2.27387844
179regulation of potassium ion transmembrane transport (GO:1901379)2.27190789
180regulation of potassium ion transmembrane transporter activity (GO:1901016)2.27042758
181negative regulation of smooth muscle cell migration (GO:0014912)2.26927213
182carnitine transmembrane transport (GO:1902603)2.26685253
183cell-matrix adhesion (GO:0007160)2.26594733
184triglyceride catabolic process (GO:0019433)2.26323766
185heart morphogenesis (GO:0003007)2.26222985
186nucleotide-sugar biosynthetic process (GO:0009226)2.26191294
187positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.26052952
188retrograde transport, vesicle recycling within Golgi (GO:0000301)2.25387849
189regulation of protein localization to plasma membrane (GO:1903076)2.25282851
190keratan sulfate catabolic process (GO:0042340)2.25247300
191heart trabecula formation (GO:0060347)2.25179341
192hippo signaling (GO:0035329)2.24930374
193regulation of heart rate (GO:0002027)2.24549893
194positive regulation of protein localization to plasma membrane (GO:1903078)2.23639287
195wound healing, spreading of epidermal cells (GO:0035313)2.22638265

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.12522986
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.70517470
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.41233848
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.67580569
5HIF1A_21447827_ChIP-Seq_MCF-7_Human2.67513021
6EZH2_22144423_ChIP-Seq_EOC_Human2.55046867
7SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.51397333
8SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.51397333
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.45168706
10* AR_21909140_ChIP-Seq_LNCAP_Human2.39208146
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.37340005
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.25047497
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.18757277
14KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.17625288
15* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.17169355
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.16926505
17* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.14833246
18SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.11336920
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.06651064
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.06651064
21ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.05817380
22GBX2_23144817_ChIP-Seq_PC3_Human2.04880551
23* ZNF263_19887448_ChIP-Seq_K562_Human2.02503414
24DROSHA_22980978_ChIP-Seq_HELA_Human1.97008142
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95241241
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84321256
27CLOCK_20551151_ChIP-Seq_293T_Human1.80452298
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80116674
29* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.77631950
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77508864
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.77091438
32* SOX2_20726797_ChIP-Seq_SW620_Human1.76877867
33TP53_16413492_ChIP-PET_HCT116_Human1.74041200
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.73783551
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73719896
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71922320
37* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71391257
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.70116768
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.66078539
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65430362
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65081553
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.64290613
43ZNF274_21170338_ChIP-Seq_K562_Hela1.63907656
44JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59625401
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59588284
46AR_21572438_ChIP-Seq_LNCaP_Human1.59355125
47TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59125396
48ATF3_27146783_Chip-Seq_COLON_Human1.58227151
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57540607
50ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.56277847
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55303767
52* TBX20_22080862_ChIP-Seq_HEART_Mouse1.55277842
53* TBX20_22328084_ChIP-Seq_HEART_Mouse1.55277842
54* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54994309
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54711416
56JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54695890
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.53356911
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52482692
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.51930332
60NRF2_20460467_ChIP-Seq_MEFs_Mouse1.51930332
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.51789542
62RXR_22158963_ChIP-Seq_LIVER_Mouse1.51351225
63NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.49039298
64UBF1/2_26484160_Chip-Seq_HMECs_Human1.45520713
65* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.45317415
66* PIAS1_25552417_ChIP-Seq_VCAP_Human1.45147292
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41510131
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41010649
69SMAD4_21799915_ChIP-Seq_A2780_Human1.38859614
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.38848353
71LXR_22158963_ChIP-Seq_LIVER_Mouse1.38666315
72ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.38143651
73EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.36256954
74* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36117671
75SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36084214
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.34587090
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33774566
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33518186
79CJUN_26792858_Chip-Seq_BT549_Human1.32640753
80WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31539332
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.30435355
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.30023604
83NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.29792207
84AHR_22903824_ChIP-Seq_MCF-7_Human1.28835134
85* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28356343
86* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28038504
87BCAT_22108803_ChIP-Seq_LS180_Human1.27317503
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26609377
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.25731509
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25353978
91ELK3_25401928_ChIP-Seq_HUVEC_Human1.24171603
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.23516324
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23432223
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.22871721
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22649605
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21093019
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19745447
98RXR_22108803_ChIP-Seq_LS180_Human1.19654134
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.19023759
100TP53_18474530_ChIP-ChIP_U2OS_Human1.18952621
101AR_19668381_ChIP-Seq_PC3_Human1.18125729
102* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17790763
103NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16945037
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16543117
105ISL1_27105846_Chip-Seq_CPCs_Mouse1.16344901
106CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16002021
107* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15961869
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14937615
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14908432
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14417756
111GATA1_22025678_ChIP-Seq_K562_Human1.14363148
112TCF4_18268006_ChIP-ChIP_LS174T_Human1.13441142
113PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11955890
114TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11523800
115* AR_25329375_ChIP-Seq_VCAP_Human1.11288100
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10245292
117ESR1_21235772_ChIP-Seq_MCF-7_Human1.10241554
118PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.08458191
119RACK7_27058665_Chip-Seq_MCF-7_Human1.08458168
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08402349
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08253199
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07986451
123HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07964145
124PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07447467
125* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07283937
126CDX2_20551321_ChIP-Seq_CACO-2_Human1.06937097
127TP53_22127205_ChIP-Seq_IMR90_Human1.06054740
128RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05953770
129SMAD4_21741376_ChIP-Seq_HESCs_Human1.05463381
130KDM2B_26808549_Chip-Seq_K562_Human1.05296115
131PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05110138
132ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04530451
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04420269
134PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03726827
135* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03565350
136SMAD3_21741376_ChIP-Seq_HESCs_Human1.02599962
137FOXA2_19822575_ChIP-Seq_HepG2_Human1.02113909
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01683711
139EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01650442
140YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00857429
141RARB_27405468_Chip-Seq_BRAIN_Mouse0.99940020
142TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.99522526
143SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99421247
144BRD4_25478319_ChIP-Seq_HGPS_Human0.98586269
145SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98444476
146SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98331640
147FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98209249
148MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97787632
149ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97650262
150* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97402570
151GATA6_25053715_ChIP-Seq_YYC3_Human0.97261033
152TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97259160
153* STAT3_23295773_ChIP-Seq_U87_Human0.96806583
154EOMES_21245162_ChIP-Seq_HESCs_Human0.95876747
155DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95220378
156* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94113105
157GATA4_25053715_ChIP-Seq_YYC3_Human0.94025937
158* SOX17_20123909_ChIP-Seq_XEN_Mouse0.93735772
159* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.93229248
160NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91975250
161* TP63_23658742_ChIP-Seq_EP156T_Human0.91493822

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.53716830
2MP0000751_myopathy3.79930673
3MP0008438_abnormal_cutaneous_collagen3.71845521
4MP0004084_abnormal_cardiac_muscle3.51196859
5MP0003950_abnormal_plasma_membrane3.47415425
6MP0004145_abnormal_muscle_electrophysio3.10098270
7* MP0004215_abnormal_myocardial_fiber3.02237668
8MP0004130_abnormal_muscle_cell2.69902275
9MP0004036_abnormal_muscle_relaxation2.63965443
10MP0003705_abnormal_hypodermis_morpholog2.62512319
11MP0010352_gastrointestinal_tract_polyps2.60526363
12MP0000749_muscle_degeneration2.52314130
13MP0003646_muscle_fatigue2.50454872
14MP0005275_abnormal_skin_tensile2.31333368
15MP0004087_abnormal_muscle_fiber2.30990309
16MP0005330_cardiomyopathy2.18980826
17MP0005503_abnormal_tendon_morphology2.13304294
18MP0008775_abnormal_heart_ventricle2.06811358
19MP0005620_abnormal_muscle_contractility2.03909363
20MP0005023_abnormal_wound_healing2.03684047
21* MP0002972_abnormal_cardiac_muscle2.03338288
22MP0004859_abnormal_synaptic_plasticity1.98264234
23MP0000013_abnormal_adipose_tissue1.85935252
24MP0003191_abnormal_cellular_cholesterol1.84809647
25MP0000569_abnormal_digit_pigmentation1.83705922
26MP0000750_abnormal_muscle_regeneration1.83417894
27MP0004233_abnormal_muscle_weight1.82645672
28* MP0004484_altered_response_of1.80932735
29MP0002060_abnormal_skin_morphology1.80369565
30MP0003279_aneurysm1.79974411
31MP0004272_abnormal_basement_membrane1.79082177
32MP0006054_spinal_hemorrhage1.74273106
33MP0009780_abnormal_chondrocyte_physiolo1.74172368
34MP0002106_abnormal_muscle_physiology1.73705563
35MP0002269_muscular_atrophy1.72881047
36MP0010630_abnormal_cardiac_muscle1.71989023
37MP0000747_muscle_weakness1.71240952
38MP0006138_congestive_heart_failure1.66876399
39MP0000759_abnormal_skeletal_muscle1.65599682
40MP0002108_abnormal_muscle_morphology1.63779352
41MP0005666_abnormal_adipose_tissue1.62785145
42MP0005623_abnormal_meninges_morphology1.62769690
43MP0005369_muscle_phenotype1.61924568
44MP0003828_pulmonary_edema1.61750223
45* MP0003137_abnormal_impulse_conducting1.60138385
46MP0001544_abnormal_cardiovascular_syste1.59813845
47MP0005385_cardiovascular_system_phenoty1.59813845
48MP0001299_abnormal_eye_distance/1.54936869
49MP0005670_abnormal_white_adipose1.53335412
50MP0003941_abnormal_skin_development1.52811322
51MP0009384_cardiac_valve_regurgitation1.45969014
52MP0001958_emphysema1.42266697
53MP0005164_abnormal_response_to1.36646597
54MP0001661_extended_life_span1.35862910
55MP0005375_adipose_tissue_phenotype1.35182608
56* MP0004085_abnormal_heartbeat1.35024853
57MP0003045_fibrosis1.33964570
58MP0003868_abnormal_feces_composition1.33728983
59MP0009046_muscle_twitch1.30934722
60MP0000003_abnormal_adipose_tissue1.30814862
61MP0003566_abnormal_cell_adhesion1.25486992
62MP0000762_abnormal_tongue_morphology1.21939875
63MP0004858_abnormal_nervous_system1.21049678
64MP0001542_abnormal_bone_strength1.20699552
65MP0004185_abnormal_adipocyte_glucose1.19764803
66MP0010368_abnormal_lymphatic_system1.18644127
67MP0000733_abnormal_muscle_development1.16955068
68MP0004510_myositis1.16215367
69MP0009053_abnormal_anal_canal1.11910766
70MP0005165_increased_susceptibility_to1.10992781
71MP0002909_abnormal_adrenal_gland1.09327881
72MP0003453_abnormal_keratinocyte_physiol1.07872294
73MP0002896_abnormal_bone_mineralization1.07781510
74MP0005197_abnormal_uvea_morphology1.07495713
75MP0009840_abnormal_foam_cell1.05999578
76MP0003635_abnormal_synaptic_transmissio1.01430803
77MP0005187_abnormal_penis_morphology1.00861490
78MP0000858_altered_metastatic_potential0.99750137
79MP0005409_darkened_coat_color0.99502847
80MP0001915_intracranial_hemorrhage0.99146460
81MP0002332_abnormal_exercise_endurance0.97116454
82MP0001243_abnormal_dermal_layer0.96463522
83MP0005257_abnormal_intraocular_pressure0.92733340
84MP0005248_abnormal_Harderian_gland0.91705453
85MP0010030_abnormal_orbit_morphology0.91543250
86MP0004147_increased_porphyrin_level0.90176328
87MP0000266_abnormal_heart_morphology0.89558825
88MP0003283_abnormal_digestive_organ0.88967891
89MP0005058_abnormal_lysosome_morphology0.87311412
90MP0010386_abnormal_urinary_bladder0.86888276
91MP0001849_ear_inflammation0.86720042
92MP0002971_abnormal_brown_adipose0.84195820
93MP0008569_lethality_at_weaning0.83866500
94MP0002295_abnormal_pulmonary_circulatio0.80579993
95MP0002234_abnormal_pharynx_morphology0.79401996
96MP0003385_abnormal_body_wall0.78531962
97MP0003221_abnormal_cardiomyocyte_apopto0.78085069
98MP0003122_maternal_imprinting0.77732648
99MP0003091_abnormal_cell_migration0.76854372
100MP0000767_abnormal_smooth_muscle0.76588831
101MP0002128_abnormal_blood_circulation0.75068684
102MP0000627_abnormal_mammary_gland0.74912367
103MP0000163_abnormal_cartilage_morphology0.74664992
104MP0005193_abnormal_anterior_eye0.73373439
105MP0003942_abnormal_urinary_system0.71433873
106MP0002970_abnormal_white_adipose0.70240248
107MP0001614_abnormal_blood_vessel0.69726521
108MP0005508_abnormal_skeleton_morphology0.68654943
109MP0002139_abnormal_hepatobiliary_system0.68521272
110MP0002090_abnormal_vision0.68235322
111MP0010234_abnormal_vibrissa_follicle0.67021754
112MP0002168_other_aberrant_phenotype0.66567220
113MP0000343_altered_response_to0.66543583
114MP0005408_hypopigmentation0.66269506
115MP0003329_amyloid_beta_deposits0.66160701
116MP0008961_abnormal_basal_metabolism0.65869650
117MP0003690_abnormal_glial_cell0.65837164
118MP0010678_abnormal_skin_adnexa0.65829296
119MP0009697_abnormal_copulation0.65457602
120MP0003959_abnormal_lean_body0.65393976
121MP0001879_abnormal_lymphatic_vessel0.64974300
122MP0003633_abnormal_nervous_system0.64125928
123MP0004270_analgesia0.63901823
124MP0003567_abnormal_fetal_cardiomyocyte0.63586175
125MP0009250_abnormal_appendicular_skeleto0.63421596
126MP0005076_abnormal_cell_differentiation0.62938843
127MP0005621_abnormal_cell_physiology0.62818037
128MP0002127_abnormal_cardiovascular_syste0.62189831
129MP0009115_abnormal_fat_cell0.61925428
130MP0001348_abnormal_lacrimal_gland0.61475700
131MP0000534_abnormal_ureter_morphology0.60841722
132MP0004782_abnormal_surfactant_physiolog0.60329111
133MP0002063_abnormal_learning/memory/cond0.60043891
134MP0003448_altered_tumor_morphology0.60031350
135MP0002877_abnormal_melanocyte_morpholog0.59320774
136MP0002064_seizures0.58912929
137MP0005595_abnormal_vascular_smooth0.58808396
138MP0000537_abnormal_urethra_morphology0.58401493
139MP0000428_abnormal_craniofacial_morphol0.57586359
140MP0002925_abnormal_cardiovascular_devel0.56390823
141MP0002067_abnormal_sensory_capabilities0.55828953
142MP0005334_abnormal_fat_pad0.55635288

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)4.55231039
2Vertebral compression fractures (HP:0002953)4.18064038
3Exercise-induced muscle cramps (HP:0003710)4.13456478
4Exercise-induced myalgia (HP:0003738)3.87036660
5Calf muscle hypertrophy (HP:0008981)3.80239979
6Osteolytic defects of the hand bones (HP:0009699)3.68935119
7Osteolytic defects of the phalanges of the hand (HP:0009771)3.68935119
8Abnormality of the calf musculature (HP:0001430)3.61225932
9Atrial fibrillation (HP:0005110)3.60250969
10Increased connective tissue (HP:0009025)3.58936629
11Broad metatarsal (HP:0001783)3.58667312
12Muscle hypertrophy of the lower extremities (HP:0008968)3.54583615
13Cerebral aneurysm (HP:0004944)3.47294920
14Type 1 muscle fiber predominance (HP:0003803)3.46261427
15Wormian bones (HP:0002645)3.36659063
16Primary atrial arrhythmia (HP:0001692)3.30645311
17Hyporeflexia of lower limbs (HP:0002600)3.24282120
18Protrusio acetabuli (HP:0003179)3.22564544
19Cervical subluxation (HP:0003308)3.20683399
20Shallow orbits (HP:0000586)3.19011592
21Right ventricular cardiomyopathy (HP:0011663)3.18184164
22Short nail (HP:0001799)3.09180042
23Follicular hyperkeratosis (HP:0007502)3.08964018
24Ventricular tachycardia (HP:0004756)3.08408456
25Supraventricular tachycardia (HP:0004755)3.07092244
26Supraventricular arrhythmia (HP:0005115)3.06926613
27Syncope (HP:0001279)3.04976162
28Muscle fiber splitting (HP:0003555)3.00443288
29Myoglobinuria (HP:0002913)3.00110229
30Lipoatrophy (HP:0100578)2.96504133
31Myotonia (HP:0002486)2.90916502
32Bundle branch block (HP:0011710)2.90260406
33Asymmetric septal hypertrophy (HP:0001670)2.87914742
34Difficulty running (HP:0009046)2.87734330
35Cardiovascular calcification (HP:0011915)2.86133995
36Premature rupture of membranes (HP:0001788)2.85392633
37Prolonged QT interval (HP:0001657)2.85131183
38Mitral stenosis (HP:0001718)2.84224505
39Aortic aneurysm (HP:0004942)2.81744786
40EMG: myopathic abnormalities (HP:0003458)2.75342114
41Abnormality of the left ventricular outflow tract (HP:0011103)2.71144011
42Subaortic stenosis (HP:0001682)2.71144011
43Abnormality of dentin (HP:0010299)2.69977934
44Spondylolisthesis (HP:0003302)2.69935299
45Dysmetric saccades (HP:0000641)2.67081108
46Aortic dissection (HP:0002647)2.67072167
47Increased variability in muscle fiber diameter (HP:0003557)2.66190595
48Ventricular arrhythmia (HP:0004308)2.64719302
49Elbow flexion contracture (HP:0002987)2.52071814
50Vascular calcification (HP:0004934)2.44074641
51Scapular winging (HP:0003691)2.42262295
52Action tremor (HP:0002345)2.39710295
53Reduced subcutaneous adipose tissue (HP:0003758)2.36123417
54Abnormality of the acetabulum (HP:0003170)2.35083811
55Arterial tortuosity (HP:0005116)2.34553194
56Lymphangioma (HP:0100764)2.33590374
57Abnormality of skeletal muscle fiber size (HP:0012084)2.33482442
58Mildly elevated creatine phosphokinase (HP:0008180)2.33289187
59Ankle contracture (HP:0006466)2.31604720
60Ventricular fibrillation (HP:0001663)2.30762352
61Blue sclerae (HP:0000592)2.30333577
62Hypoplastic ischia (HP:0003175)2.29382091
63Mitral valve prolapse (HP:0001634)2.28355112
64Ulnar bowing (HP:0003031)2.26320380
65Aneurysm (HP:0002617)2.25094972
66Abnormal delivery (HP:0001787)2.22248178
67Mitral regurgitation (HP:0001653)2.21877800
68Vascular tortuosity (HP:0004948)2.21389404
69Dilated cardiomyopathy (HP:0001644)2.18230840
70Spinal rigidity (HP:0003306)2.16531902
71Glucose intolerance (HP:0000833)2.16492089
72Difficulty climbing stairs (HP:0003551)2.13303617
73Abnormality of the ischium (HP:0003174)2.11529206
74Abnormality of carpal bone ossification (HP:0006257)2.10564704
75Abnormal EKG (HP:0003115)2.08918515
76Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.08811013
77Upper limb amyotrophy (HP:0009129)2.06662901
78Distal upper limb amyotrophy (HP:0007149)2.06662901
79Dilatation of the ascending aorta (HP:0005111)2.05982391
80Coxa vara (HP:0002812)2.05634978
81Skin nodule (HP:0200036)2.03884828
82Striae distensae (HP:0001065)2.03432598
83Nuclear cataract (HP:0100018)2.03246646
84Tetraparesis (HP:0002273)2.02433615
85Myocardial infarction (HP:0001658)2.02248893
86Natal tooth (HP:0000695)2.00998940
87Biconcave vertebral bodies (HP:0004586)1.99971491
88Palpitations (HP:0001962)1.99134652
89Ketoacidosis (HP:0001993)1.96600310
90Aortic regurgitation (HP:0001659)1.96578516
91Neonatal short-limb short stature (HP:0008921)1.96467001
92Slender build (HP:0001533)1.94503093
93Hyperextensible skin (HP:0000974)1.94127511
94Enlarged penis (HP:0000040)1.93966800
95Abnormal atrioventricular conduction (HP:0005150)1.93458975
96Heart block (HP:0012722)1.92012385
97Back pain (HP:0003418)1.91466541
98Neurofibrillary tangles (HP:0002185)1.91458250
99Coronal craniosynostosis (HP:0004440)1.89991055
100Atrophic scars (HP:0001075)1.89788600
101Abnormality of the intrinsic pathway (HP:0010989)1.89033260
102Conjugated hyperbilirubinemia (HP:0002908)1.88892012
103Generalized amyotrophy (HP:0003700)1.87087707
104Joint laxity (HP:0001388)1.86738332
105Acanthosis nigricans (HP:0000956)1.86377269
106Round ear (HP:0100830)1.85855922
107Muscle fiber inclusion bodies (HP:0100299)1.85844264
108Broad face (HP:0000283)1.85106282
109Hydroxyprolinuria (HP:0003080)1.83726719
110Abnormality of proline metabolism (HP:0010907)1.83726719
111Achilles tendon contracture (HP:0001771)1.83189821
112Abnormal ossification of hand bones (HP:0005921)1.83098041
113Knee flexion contracture (HP:0006380)1.82592469
114Proximal amyotrophy (HP:0007126)1.82373275
115Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.82047770
116Lower limb amyotrophy (HP:0007210)1.81929747
117Cerebral inclusion bodies (HP:0100314)1.80937643
118Hypoalphalipoproteinemia (HP:0003233)1.80483745
119Abnormality of the distal phalanges of the toes (HP:0010182)1.80396522
120Soft skin (HP:0000977)1.79403943
121Distal lower limb amyotrophy (HP:0008944)1.78138655
122Fragile skin (HP:0001030)1.77544815
123Bladder diverticulum (HP:0000015)1.77383199
124Abnormality of the common coagulation pathway (HP:0010990)1.76578058
125Deep venous thrombosis (HP:0002625)1.76269291
126Ankyloglossia (HP:0010296)1.75748970
127Syringomyelia (HP:0003396)1.74864824
128Spinal cord lesions (HP:0100561)1.74864824
129Distal lower limb muscle weakness (HP:0009053)1.74201563
130Hyperacusis (HP:0010780)1.73535992
131Focal segmental glomerulosclerosis (HP:0000097)1.73200836
132Spinal cord compression (HP:0002176)1.72806147
133Termporal pattern (HP:0011008)1.72488384
134Insidious onset (HP:0003587)1.72488384
135Muscle stiffness (HP:0003552)1.72468906
136Turricephaly (HP:0000262)1.70029613
137Overgrowth (HP:0001548)1.69885387
138Rhabdomyolysis (HP:0003201)1.69775068
139Abnormality of oral frenula (HP:0000190)1.69434433
140Abnormality of the 4th metacarpal (HP:0010012)1.67677276
141Protruding ear (HP:0000411)1.67008223
142Limb-girdle muscle atrophy (HP:0003797)1.66858904
143Focal seizures (HP:0007359)1.66552021
144Muscular dystrophy (HP:0003560)1.66126229
145Pterygium (HP:0001059)1.65868582
146Advanced eruption of teeth (HP:0006288)1.65799807
147Delayed cranial suture closure (HP:0000270)1.65617258
148Visual hallucinations (HP:0002367)1.65098297
149Narrow palate (HP:0000189)1.65040429
150Genu recurvatum (HP:0002816)1.64767631
151Insulin resistance (HP:0000855)1.64266613
152Buphthalmos (HP:0000557)1.63664720
153Exostoses (HP:0100777)1.63416888
154Absent frontal sinuses (HP:0002688)1.63335529
155Focal motor seizures (HP:0011153)1.63294329
156Abnormality of the Achilles tendon (HP:0005109)1.62817360
157Atrioventricular block (HP:0001678)1.61294552
158Bell-shaped thorax (HP:0001591)1.60671473
159Long toe (HP:0010511)1.60615145
160Hamartoma of the eye (HP:0010568)1.59816505
161Distal arthrogryposis (HP:0005684)1.59653302
162Subacute progressive viral hepatitis (HP:0006572)1.58338300
163Macroorchidism (HP:0000053)1.58263165
164Short 4th metacarpal (HP:0010044)1.56459544
165Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.56459544
166Genetic anticipation (HP:0003743)1.55424123
167Frequent falls (HP:0002359)1.55364244

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.27345869
2TTN4.09590961
3MET4.07693022
4EPHA23.32593090
5ERBB42.84013954
6LMTK22.83678702
7RIPK12.81655148
8PHKG22.69472611
9PHKG12.69472611
10PKN22.63103065
11TRIB32.58109326
12OBSCN2.48769045
13CAMK1D2.31125764
14DMPK2.24421709
15CAMK1G2.11661841
16SIK12.01046227
17LIMK12.00852308
18TESK12.00703545
19PDGFRA2.00141690
20TGFBR21.97651906
21PAK41.97132622
22IRAK31.96496295
23CAMKK21.94969071
24DDR21.84333811
25PIK3CA1.74859050
26LATS11.73164603
27FRK1.66563863
28PDK31.59582713
29PDK41.59582713
30NEK11.56109601
31ICK1.52532286
32AKT31.40804584
33ERN11.40799798
34NTRK31.35784696
35MOS1.32178996
36CAMKK11.30509898
37FER1.28686781
38PDK21.27526781
39MAP3K41.27521694
40LATS21.24230309
41MYLK1.19895845
42EPHB11.18815468
43MAP2K41.17371440
44WNK11.17107664
45MAP3K91.15471774
46STK381.15426848
47CDK81.13528106
48PTK61.09693560
49SCYL21.09525116
50FGFR21.09458845
51STK38L1.07884085
52EEF2K1.07330580
53MAP3K121.03546502
54PAK31.03083228
55PBK1.02635960
56INSRR1.02030471
57EIF2AK11.01789102
58RET1.01704002
59PAK61.00561287
60BMX0.96575157
61CAMK40.95431673
62BRSK20.94819036
63MINK10.94344060
64PLK20.93261896
65ARAF0.91497389
66GRK70.89721514
67KSR20.89578641
68NEK90.89405737
69ABL20.88566336
70PINK10.87227763
71DAPK20.86153613
72KSR10.85025595
73SGK30.84077358
74MAP3K70.83990121
75MAPK120.83735612
76PRKAA20.81898498
77FGFR10.81098343
78NME20.78824835
79PRKAA10.77763747
80EPHB20.76439725
81ROCK10.74789305
82PRKD10.74141949
83CAMK10.73704529
84ERBB30.73139239
85MELK0.71782210
86TRPM70.71777296
87STK390.70801711
88PTK20.70081989
89SGK20.68852263
90MST40.68798625
91CDC42BPA0.68526189
92JAK10.67776223
93FGFR30.66034550
94NTRK10.65986978
95PDGFRB0.65986418
96PTK2B0.65245394
97PRKD30.64567254
98BRSK10.63462995
99PRKCH0.62630595
100MAPKAPK30.61848017
101MAP3K20.61601721
102CAMK2D0.60762468
103STK240.59116278
104EIF2AK30.58940486
105SGK10.56662346
106MAP2K10.56079110
107BCKDK0.55283663
108CDK120.51100633
109GSK3A0.51064889
110MTOR0.50080421
111PAK20.49629283
112PRKCE0.49504217
113CAMK2A0.48880200
114PRKG20.48792002
115PDPK10.47989230
116CAMK2G0.47582524
117STK100.46490980
118STK30.45089999
119SIK20.43918798
120PDK10.43008988
121CDK50.42606947
122AKT20.42443535
123CDK60.40792307
124FLT30.40645301
125MAP3K30.40339527
126RPS6KA30.40315991
127WNK40.38886853
128PIK3CG0.38686473
129PRKACB0.38662443
130ROCK20.38597557
131ERBB20.38455661
132MAP3K60.38161199
133ILK0.38126113
134JAK20.37903100
135SGK4940.37633700
136SGK2230.37633700
137EPHA30.37039077
138SRC0.35406741
139PRKD20.35153514
140GRK50.35042831
141FGFR40.32913620
142CDK90.31455826
143MAP3K130.31408141
144NEK20.30310838
145MAP3K80.30014992
146CAMK2B0.29152063
147PIM20.27258331
148MAPK110.27099684
149ADRBK10.25468321

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.73582155
2Dilated cardiomyopathy_Homo sapiens_hsa054142.54648663
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.32627518
4Vitamin B6 metabolism_Homo sapiens_hsa007502.04255843
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.92892171
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.88968065
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84819460
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77972446
9Cardiac muscle contraction_Homo sapiens_hsa042601.72003809
10Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.66333613
11Pentose phosphate pathway_Homo sapiens_hsa000301.57913874
12Complement and coagulation cascades_Homo sapiens_hsa046101.54557610
13Phenylalanine metabolism_Homo sapiens_hsa003601.48542843
14Small cell lung cancer_Homo sapiens_hsa052221.47714453
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47287367
16Sulfur metabolism_Homo sapiens_hsa009201.47193170
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.45982820
18Renin secretion_Homo sapiens_hsa049241.45454605
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44300155
20Type II diabetes mellitus_Homo sapiens_hsa049301.43626994
21Galactose metabolism_Homo sapiens_hsa000521.42526247
22Long-term potentiation_Homo sapiens_hsa047201.42035401
23Propanoate metabolism_Homo sapiens_hsa006401.41222508
24Circadian entrainment_Homo sapiens_hsa047131.39332318
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38223340
26Fructose and mannose metabolism_Homo sapiens_hsa000511.37173631
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37116515
28Nicotine addiction_Homo sapiens_hsa050331.36932280
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.35816430
30Gastric acid secretion_Homo sapiens_hsa049711.34704426
31Oxytocin signaling pathway_Homo sapiens_hsa049211.34532442
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.30078644
33Nitrogen metabolism_Homo sapiens_hsa009101.30028387
34Fatty acid degradation_Homo sapiens_hsa000711.29170417
35Salivary secretion_Homo sapiens_hsa049701.28515986
36Focal adhesion_Homo sapiens_hsa045101.28503330
37ECM-receptor interaction_Homo sapiens_hsa045121.26165349
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25048744
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24365022
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24090862
41Other glycan degradation_Homo sapiens_hsa005111.24088028
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23366327
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23085866
44Fatty acid biosynthesis_Homo sapiens_hsa000611.18078582
45Insulin secretion_Homo sapiens_hsa049111.16017646
46Calcium signaling pathway_Homo sapiens_hsa040201.15511018
47Glucagon signaling pathway_Homo sapiens_hsa049221.13407179
48Biosynthesis of amino acids_Homo sapiens_hsa012301.12297667
49Fatty acid metabolism_Homo sapiens_hsa012121.12135425
50N-Glycan biosynthesis_Homo sapiens_hsa005101.10772628
51GABAergic synapse_Homo sapiens_hsa047271.09386500
52Insulin resistance_Homo sapiens_hsa049311.08712026
53Glutamatergic synapse_Homo sapiens_hsa047241.08369934
54Hippo signaling pathway_Homo sapiens_hsa043901.07182285
55Insulin signaling pathway_Homo sapiens_hsa049101.07104234
56cAMP signaling pathway_Homo sapiens_hsa040241.03813111
57Proteoglycans in cancer_Homo sapiens_hsa052051.00806610
58Long-term depression_Homo sapiens_hsa047301.00560065
59Vibrio cholerae infection_Homo sapiens_hsa051100.99939864
60Tyrosine metabolism_Homo sapiens_hsa003500.99920231
61Estrogen signaling pathway_Homo sapiens_hsa049150.99658835
62mTOR signaling pathway_Homo sapiens_hsa041500.98951252
63GnRH signaling pathway_Homo sapiens_hsa049120.98935967
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98145206
65Bladder cancer_Homo sapiens_hsa052190.97849300
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96095844
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94645220
68Cholinergic synapse_Homo sapiens_hsa047250.94612160
69Adherens junction_Homo sapiens_hsa045200.94567917
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.94493935
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.93957051
72Morphine addiction_Homo sapiens_hsa050320.93497418
73Amoebiasis_Homo sapiens_hsa051460.92921285
74AMPK signaling pathway_Homo sapiens_hsa041520.92506926
75MicroRNAs in cancer_Homo sapiens_hsa052060.92078719
76Gap junction_Homo sapiens_hsa045400.91825897
77Glioma_Homo sapiens_hsa052140.89969058
78PPAR signaling pathway_Homo sapiens_hsa033200.89343844
79Thyroid cancer_Homo sapiens_hsa052160.89336132
80PI3K-Akt signaling pathway_Homo sapiens_hsa041510.87851440
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86428534
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86311843
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85964258
84Synaptic vesicle cycle_Homo sapiens_hsa047210.84847892
85Taste transduction_Homo sapiens_hsa047420.84625356
86Amphetamine addiction_Homo sapiens_hsa050310.83977690
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83493368
88Sphingolipid metabolism_Homo sapiens_hsa006000.82754694
89TGF-beta signaling pathway_Homo sapiens_hsa043500.82658979
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.82061413
91Glutathione metabolism_Homo sapiens_hsa004800.81966019
92Dopaminergic synapse_Homo sapiens_hsa047280.81091400
93Olfactory transduction_Homo sapiens_hsa047400.79643163
94Carbon metabolism_Homo sapiens_hsa012000.79225193
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79019269
96Prion diseases_Homo sapiens_hsa050200.78717481
97Pancreatic cancer_Homo sapiens_hsa052120.77582198
98Fatty acid elongation_Homo sapiens_hsa000620.75504193
99Histidine metabolism_Homo sapiens_hsa003400.74954292
100Thyroid hormone synthesis_Homo sapiens_hsa049180.73738865
101Renal cell carcinoma_Homo sapiens_hsa052110.73614444
102Melanogenesis_Homo sapiens_hsa049160.73016794
103Protein digestion and absorption_Homo sapiens_hsa049740.71918759
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71131664
105Bile secretion_Homo sapiens_hsa049760.70788970
106Viral myocarditis_Homo sapiens_hsa054160.70580645
107Butanoate metabolism_Homo sapiens_hsa006500.68508932
108Starch and sucrose metabolism_Homo sapiens_hsa005000.66551129
109Pancreatic secretion_Homo sapiens_hsa049720.64891700
110Platelet activation_Homo sapiens_hsa046110.64463376
111Circadian rhythm_Homo sapiens_hsa047100.64237996
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64108239
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63885331
114HIF-1 signaling pathway_Homo sapiens_hsa040660.63591565
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.63307534
116Lysosome_Homo sapiens_hsa041420.63006675
117beta-Alanine metabolism_Homo sapiens_hsa004100.62996672
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62808734
119Glycerolipid metabolism_Homo sapiens_hsa005610.61959115
120Pathways in cancer_Homo sapiens_hsa052000.61740934
121Lysine degradation_Homo sapiens_hsa003100.61571684
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61425765
123Selenocompound metabolism_Homo sapiens_hsa004500.59563803
124Melanoma_Homo sapiens_hsa052180.59102374
125Folate biosynthesis_Homo sapiens_hsa007900.57581174
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57312176
127Arginine biosynthesis_Homo sapiens_hsa002200.57158382
128Rap1 signaling pathway_Homo sapiens_hsa040150.56845889
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53463331
130Axon guidance_Homo sapiens_hsa043600.53342307
131Endometrial cancer_Homo sapiens_hsa052130.53188440
132Pyruvate metabolism_Homo sapiens_hsa006200.53176099
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.52484452
134Renin-angiotensin system_Homo sapiens_hsa046140.52358180
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51098951
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50388007
137Glycosaminoglycan degradation_Homo sapiens_hsa005310.50323418
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.49967322
139Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48181225
140Tight junction_Homo sapiens_hsa045300.46875538
141Chronic myeloid leukemia_Homo sapiens_hsa052200.46772566
142Dorso-ventral axis formation_Homo sapiens_hsa043200.46280633
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46184811
144VEGF signaling pathway_Homo sapiens_hsa043700.45780196
145Arginine and proline metabolism_Homo sapiens_hsa003300.45521344
146Shigellosis_Homo sapiens_hsa051310.44809608
147Choline metabolism in cancer_Homo sapiens_hsa052310.43756221
148Steroid hormone biosynthesis_Homo sapiens_hsa001400.43588081
149ErbB signaling pathway_Homo sapiens_hsa040120.43359599
150Endocytosis_Homo sapiens_hsa041440.42807853

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