ASPHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)8.01756880
2synaptic vesicle maturation (GO:0016188)7.72366155
3glutamate secretion (GO:0014047)7.31326712
4cellular potassium ion homeostasis (GO:0030007)5.34768297
5neurotransmitter secretion (GO:0007269)5.31948626
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.20536443
7positive regulation of synapse maturation (GO:0090129)5.01433088
8locomotory exploration behavior (GO:0035641)4.89917288
9presynaptic membrane assembly (GO:0097105)4.80909831
10sodium ion export (GO:0071436)4.70975023
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.56755113
12regulation of synapse structural plasticity (GO:0051823)4.43540981
13presynaptic membrane organization (GO:0097090)4.43345331
14neuron cell-cell adhesion (GO:0007158)4.41062936
15neuronal action potential propagation (GO:0019227)4.39852326
16cerebellar granule cell differentiation (GO:0021707)4.31010292
17postsynaptic membrane organization (GO:0001941)4.29089495
18exploration behavior (GO:0035640)4.28624357
19neuronal ion channel clustering (GO:0045161)4.23106692
20layer formation in cerebral cortex (GO:0021819)4.22316014
21neurotransmitter transport (GO:0006836)4.09770035
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.07279492
23positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.98070092
24amino acid import (GO:0043090)3.96055809
25positive regulation of neurotransmitter transport (GO:0051590)3.88801143
26synaptic vesicle endocytosis (GO:0048488)3.87049578
27regulation of synapse maturation (GO:0090128)3.80226268
28regulation of neurotransmitter levels (GO:0001505)3.77539897
29regulation of synaptic plasticity (GO:0048167)3.77522138
30cerebral cortex radially oriented cell migration (GO:0021799)3.75827468
31cell migration in hindbrain (GO:0021535)3.75685515
32regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.74181350
33protein localization to synapse (GO:0035418)3.73781027
34positive regulation of neurotransmitter secretion (GO:0001956)3.73025783
35regulation of neurotransmitter secretion (GO:0046928)3.70954399
36regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.64418137
37cerebellar Purkinje cell layer development (GO:0021680)3.63949112
38positive regulation of dendritic spine morphogenesis (GO:0061003)3.63922063
39neuromuscular process controlling balance (GO:0050885)3.63331724
40potassium ion homeostasis (GO:0055075)3.60875774
41negative regulation of synaptic transmission, GABAergic (GO:0032229)3.59790956
42glutamate receptor signaling pathway (GO:0007215)3.55638142
43vocalization behavior (GO:0071625)3.53501414
44positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.50454611
45startle response (GO:0001964)3.50306003
46gamma-aminobutyric acid transport (GO:0015812)3.48056577
47regulation of dendritic spine morphogenesis (GO:0061001)3.47936843
48dendritic spine organization (GO:0097061)3.47416504
49long-chain fatty acid biosynthetic process (GO:0042759)3.45768543
50righting reflex (GO:0060013)3.45723195
51synaptic transmission, glutamatergic (GO:0035249)3.45279408
52regulation of ARF protein signal transduction (GO:0032012)3.41433382
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.41317044
54G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.40770652
55regulation of voltage-gated calcium channel activity (GO:1901385)3.39198153
56regulation of neurotransmitter transport (GO:0051588)3.33879138
57cerebellar Purkinje cell differentiation (GO:0021702)3.31359377
58axon ensheathment in central nervous system (GO:0032291)3.30109238
59central nervous system myelination (GO:0022010)3.30109238
60establishment of mitochondrion localization (GO:0051654)3.27288444
61negative regulation of dendrite morphogenesis (GO:0050774)3.26073509
62neuron-neuron synaptic transmission (GO:0007270)3.21657560
63transmission of nerve impulse (GO:0019226)3.21546903
64potassium ion import (GO:0010107)3.18712942
65regulation of dendritic spine development (GO:0060998)3.15777318
66cellular sodium ion homeostasis (GO:0006883)3.15690091
67neuromuscular process controlling posture (GO:0050884)3.11397037
68cell communication by electrical coupling (GO:0010644)3.09397729
69cytoskeletal anchoring at plasma membrane (GO:0007016)3.08915998
70regulation of short-term neuronal synaptic plasticity (GO:0048172)3.06607485
71dicarboxylic acid transport (GO:0006835)3.05507086
72acidic amino acid transport (GO:0015800)3.04989226
73regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.01801985
74neuron recognition (GO:0008038)3.00365754
75regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.99375327
76regulation of timing of cell differentiation (GO:0048505)2.99238413
77regulation of glutamate receptor signaling pathway (GO:1900449)2.99210367
78establishment of synaptic vesicle localization (GO:0097480)2.99143661
79synaptic vesicle transport (GO:0048489)2.99143661
80positive regulation of synapse assembly (GO:0051965)2.97606374
81regulation of synaptic transmission (GO:0050804)2.97374751
82gamma-aminobutyric acid signaling pathway (GO:0007214)2.96026554
83neuromuscular synaptic transmission (GO:0007274)2.91446857
84mating behavior (GO:0007617)2.90331200
85positive regulation of synaptic transmission, GABAergic (GO:0032230)2.90279889
86vesicle docking involved in exocytosis (GO:0006904)2.89990229
87regulation of respiratory system process (GO:0044065)2.89298107
88response to auditory stimulus (GO:0010996)2.88201421
89synaptic transmission (GO:0007268)2.85845652
90positive regulation of dendrite development (GO:1900006)2.84843601
91regulation of respiratory gaseous exchange (GO:0043576)2.84299001
92cyclic nucleotide catabolic process (GO:0009214)2.83562173
93neuromuscular process (GO:0050905)2.81115401
94cell differentiation in hindbrain (GO:0021533)2.81049726
95mitochondrion transport along microtubule (GO:0047497)2.80913395
96establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.80913395
97positive regulation of membrane potential (GO:0045838)2.80025130
98regulation of synaptic transmission, GABAergic (GO:0032228)2.79210059
99limb bud formation (GO:0060174)2.78963792
100positive regulation of action potential (GO:0045760)2.75455077
101cAMP catabolic process (GO:0006198)2.73335393
102regulation of excitatory postsynaptic membrane potential (GO:0060079)2.71662795
103omega-hydroxylase P450 pathway (GO:0097267)2.68577830
104neuronal action potential (GO:0019228)2.65107969
105G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.64900758
106mechanosensory behavior (GO:0007638)2.64069809
107developmental pigmentation (GO:0048066)2.62717354
108dendritic spine morphogenesis (GO:0060997)2.62453265
109negative regulation of execution phase of apoptosis (GO:1900118)2.62100433
110adult walking behavior (GO:0007628)2.61922849
111synaptic vesicle exocytosis (GO:0016079)2.61585827
112neurotransmitter-gated ion channel clustering (GO:0072578)2.61145684
113keratinocyte development (GO:0003334)2.61075934
114synapse assembly (GO:0007416)2.60857013
115regulation of synaptic vesicle exocytosis (GO:2000300)2.59507266
116positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.59505531
117opioid receptor signaling pathway (GO:0038003)2.59206660
118regulation of synapse assembly (GO:0051963)2.58987448
119regulation of development, heterochronic (GO:0040034)2.57901658
120regulation of pigment cell differentiation (GO:0050932)2.57034769
121detection of calcium ion (GO:0005513)2.56694196
122negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.56014437
123regulation of postsynaptic membrane potential (GO:0060078)2.54600646
124regulation of dopamine metabolic process (GO:0042053)2.54313102
125regulation of catecholamine metabolic process (GO:0042069)2.54313102
126central nervous system projection neuron axonogenesis (GO:0021952)2.53754927
127auditory behavior (GO:0031223)2.51665939
128reflex (GO:0060004)2.50725233
129positive regulation of dendritic spine development (GO:0060999)2.50441611
130regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.49902585
131negative regulation of heart rate (GO:0010459)2.49229376
132regulation of vesicle fusion (GO:0031338)2.47123967
133long-term memory (GO:0007616)2.46845538
134positive regulation of meiosis (GO:0045836)2.45911141
135nonmotile primary cilium assembly (GO:0035058)2.44539213
136cell differentiation involved in metanephros development (GO:0072202)2.43210582
137negative regulation of neurotransmitter transport (GO:0051589)2.40662246
138cranial nerve morphogenesis (GO:0021602)2.40491386
139regulation of synaptic vesicle transport (GO:1902803)2.40299742
140central nervous system neuron axonogenesis (GO:0021955)2.39336687
141respiratory chain complex IV assembly (GO:0008535)2.38504660
142superoxide anion generation (GO:0042554)2.38272184
143adult behavior (GO:0030534)2.38123682
144adult locomotory behavior (GO:0008344)2.37853331
145cytochrome complex assembly (GO:0017004)2.36628218
146retina layer formation (GO:0010842)2.35883404
147neuron remodeling (GO:0016322)2.35346711
148GPI anchor biosynthetic process (GO:0006506)2.35187548
149protein localization to cilium (GO:0061512)2.34964195
150photoreceptor cell differentiation (GO:0046530)2.33580692
151eye photoreceptor cell differentiation (GO:0001754)2.33580692
152L-amino acid import (GO:0043092)2.32825055
153serotonin receptor signaling pathway (GO:0007210)2.31540055
154regulation of neuronal synaptic plasticity (GO:0048168)2.31265829
155membrane depolarization (GO:0051899)2.31124905
156learning (GO:0007612)2.30478714
157regulation of long-term neuronal synaptic plasticity (GO:0048169)2.30305223
158regulation of glutamate secretion (GO:0014048)2.29790235
159axonal fasciculation (GO:0007413)2.29214486
160synaptic transmission, dopaminergic (GO:0001963)2.28599853
161regulation of synaptic transmission, glutamatergic (GO:0051966)2.28277424
162positive regulation of meiotic cell cycle (GO:0051446)2.28036881
163preassembly of GPI anchor in ER membrane (GO:0016254)2.27329586

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.35475508
2GBX2_23144817_ChIP-Seq_PC3_Human4.21207287
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.39621284
4RARB_27405468_Chip-Seq_BRAIN_Mouse3.17478543
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.09745452
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.01427397
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94087338
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70741194
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.57746182
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.57316201
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53779267
12ERG_21242973_ChIP-ChIP_JURKAT_Human2.51498021
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39939440
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.39714021
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.36496194
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33688318
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31796468
18TAF15_26573619_Chip-Seq_HEK293_Human2.31564823
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31323638
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26457744
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26457744
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24822724
23ZFP281_18757296_ChIP-ChIP_E14_Mouse2.20923254
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19274805
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18705008
26KDM2B_26808549_Chip-Seq_K562_Human2.13649086
27CBX2_27304074_Chip-Seq_ESCs_Mouse2.10044781
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.09025801
29RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.06960402
30LXR_22292898_ChIP-Seq_THP-1_Human2.05133041
31DNAJC2_21179169_ChIP-ChIP_NT2_Human2.03751467
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93977447
33RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.93712848
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.91855087
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91394278
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89671089
37EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.89321051
38REST_21632747_ChIP-Seq_MESCs_Mouse1.86911804
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.86904516
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85278413
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.84380727
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82456150
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82112167
44VDR_22108803_ChIP-Seq_LS180_Human1.78789596
45P300_19829295_ChIP-Seq_ESCs_Human1.75892475
46IGF1R_20145208_ChIP-Seq_DFB_Human1.75231440
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73579268
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.72197335
49RNF2_27304074_Chip-Seq_NSC_Mouse1.72031877
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71833277
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71725672
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70198123
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69033536
54* CTCF_27219007_Chip-Seq_Bcells_Human1.66746045
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.66041516
56TET1_21490601_ChIP-Seq_MESCs_Mouse1.62896785
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61428131
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60934003
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59860061
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.57777595
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57432239
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56724921
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55242883
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.54593478
65SMAD4_21799915_ChIP-Seq_A2780_Human1.54453871
66AR_21572438_ChIP-Seq_LNCaP_Human1.54253631
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.53871733
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53420236
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53274953
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51710162
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51453375
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.50274019
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.49853684
74ER_23166858_ChIP-Seq_MCF-7_Human1.49668731
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.48464946
76ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47877928
77P53_22387025_ChIP-Seq_ESCs_Mouse1.47583020
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.46963590
79DROSHA_22980978_ChIP-Seq_HELA_Human1.46272236
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.45780863
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.44890674
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44321655
83FUS_26573619_Chip-Seq_HEK293_Human1.43455369
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.42560980
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.41619147
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.41058138
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40051622
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37641139
89SMC4_20622854_ChIP-Seq_HELA_Human1.37553921
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37342467
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.37091053
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.36760035
93NMYC_18555785_Chip-Seq_ESCs_Mouse1.36001729
94CMYC_18555785_Chip-Seq_ESCs_Mouse1.35649271
95SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34970194
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.34374618
97P300_18555785_Chip-Seq_ESCs_Mouse1.33821984
98TET1_21451524_ChIP-Seq_MESCs_Mouse1.33320312
99RUNX1_27457419_Chip-Seq_LIVER_Mouse1.32049893
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30934619
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29797769
102* P68_20966046_ChIP-Seq_HELA_Human1.27670705
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25816633
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.24137398
105SOX2_18555785_Chip-Seq_ESCs_Mouse1.24103042
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23783732
107REST_18959480_ChIP-ChIP_MESCs_Mouse1.23086699
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22575168
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22319968
110RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21804228
111LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20648236
112GATA1_26923725_Chip-Seq_HPCs_Mouse1.20485577
113TRIM28_21343339_ChIP-Seq_HEK293_Human1.20280985
114RUNX2_22187159_ChIP-Seq_PCA_Human1.19665057
115RING1B_27294783_Chip-Seq_NPCs_Mouse1.19545785
116CREB1_26743006_Chip-Seq_LNCaP_Human1.19437712
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17483688
118KLF4_18555785_Chip-Seq_ESCs_Mouse1.17187766
119SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16829091
120PU1_27457419_Chip-Seq_LIVER_Mouse1.16327759
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15861666
122STAT3_23295773_ChIP-Seq_U87_Human1.15562895
123OCT4_18555785_Chip-Seq_ESCs_Mouse1.15092027
124POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15078826
125TCF4_23295773_ChIP-Seq_U87_Human1.14748598
126TP53_20018659_ChIP-ChIP_R1E_Mouse1.13815821
127ZFX_18555785_Chip-Seq_ESCs_Mouse1.13185631
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12500153
129SMAD1_18555785_Chip-Seq_ESCs_Mouse1.12261336
130SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12171422
131CTCF_18555785_Chip-Seq_ESCs_Mouse1.11439505
132AR_25329375_ChIP-Seq_VCAP_Human1.10437272
133ESRRB_18555785_Chip-Seq_ESCs_Mouse1.10027335
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10022354
135KDM2B_26808549_Chip-Seq_REH_Human1.08285757
136IRF1_19129219_ChIP-ChIP_H3396_Human1.08199486
137OCT4_19829295_ChIP-Seq_ESCs_Human1.07458422
138SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05458104
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03751730
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03480204
141* RACK7_27058665_Chip-Seq_MCF-7_Human1.03381353
142POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03227468
143TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03227468
144KDM2B_26808549_Chip-Seq_DND41_Human1.03019569
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02428651
146VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01793680
147NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00974017
148ZNF263_19887448_ChIP-Seq_K562_Human1.00921715
149MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00732757
150TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98497163
151WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96612216
152ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95904403
153NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.93487866
154CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91361616
155SA1_27219007_Chip-Seq_ERYTHROID_Human0.90370624
156TP53_23651856_ChIP-Seq_MEFs_Mouse0.88983116
157NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87311463
158KLF4_19829295_ChIP-Seq_ESCs_Human0.87070207
159CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85955065
160GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.85513136
161KDM2B_26808549_Chip-Seq_JURKAT_Human0.85395660
162GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85368239
163AR_19668381_ChIP-Seq_PC3_Human0.85136902
164ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83338670
165MYC_19915707_ChIP-ChIP_AK7_Human0.83038555
166NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82557771
167PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81224921
168DPY_21335234_ChIP-Seq_ESCs_Mouse0.79649234
169RUNX1_26923725_Chip-Seq_HPCs_Mouse0.78743511
170SA1_27219007_Chip-Seq_Bcells_Human0.78375226
171DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77883740
172SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76970809
173STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.76897731

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.64227721
2MP0001188_hyperpigmentation3.74927943
3MP0003136_yellow_coat_color3.29971366
4MP0006292_abnormal_olfactory_placode3.23448746
5MP0005409_darkened_coat_color3.04377012
6MP0004859_abnormal_synaptic_plasticity2.88282178
7MP0005423_abnormal_somatic_nervous2.79935750
8MP0003123_paternal_imprinting2.51027470
9MP0003329_amyloid_beta_deposits2.49504596
10MP0003635_abnormal_synaptic_transmissio2.45643171
11MP0009745_abnormal_behavioral_response2.43265358
12MP0001486_abnormal_startle_reflex2.36977098
13MP0001986_abnormal_taste_sensitivity2.34855741
14MP0002272_abnormal_nervous_system2.24625268
15MP0006276_abnormal_autonomic_nervous2.22765166
16MP0001968_abnormal_touch/_nociception2.22576629
17MP0000566_synostosis2.11146435
18MP0004270_analgesia2.10320551
19MP0002064_seizures2.10283395
20MP0005645_abnormal_hypothalamus_physiol2.09463950
21MP0002572_abnormal_emotion/affect_behav2.03403438
22MP0005171_absent_coat_pigmentation1.96622516
23MP0002735_abnormal_chemical_nociception1.96370768
24MP0002063_abnormal_learning/memory/cond1.94959720
25MP0009046_muscle_twitch1.94175202
26MP0002876_abnormal_thyroid_physiology1.89730576
27MP0004742_abnormal_vestibular_system1.89076677
28MP0002734_abnormal_mechanical_nocicepti1.84226829
29MP0000015_abnormal_ear_pigmentation1.83945758
30MP0002067_abnormal_sensory_capabilities1.80183171
31MP0005646_abnormal_pituitary_gland1.74461246
32MP0002736_abnormal_nociception_after1.72717175
33MP0001984_abnormal_olfaction1.69784771
34MP0002557_abnormal_social/conspecific_i1.67992349
35MP0010386_abnormal_urinary_bladder1.66009923
36MP0000778_abnormal_nervous_system1.62102083
37MP0001529_abnormal_vocalization1.59332176
38MP0001905_abnormal_dopamine_level1.58538101
39MP0002638_abnormal_pupillary_reflex1.58528741
40MP0001970_abnormal_pain_threshold1.56904524
41MP0003787_abnormal_imprinting1.53008829
42MP0004142_abnormal_muscle_tone1.52070294
43MP0003633_abnormal_nervous_system1.51577180
44MP0002102_abnormal_ear_morphology1.50902263
45MP0002184_abnormal_innervation1.50057831
46MP0005379_endocrine/exocrine_gland_phen1.47388933
47MP0001501_abnormal_sleep_pattern1.46941744
48MP0002733_abnormal_thermal_nociception1.46918297
49MP0004381_abnormal_hair_follicle1.42903665
50MP0001348_abnormal_lacrimal_gland1.42396329
51MP0009379_abnormal_foot_pigmentation1.41493577
52MP0005551_abnormal_eye_electrophysiolog1.40409694
53MP0002277_abnormal_respiratory_mucosa1.36538549
54MP0001502_abnormal_circadian_rhythm1.36503411
55MP0001440_abnormal_grooming_behavior1.36141628
56MP0003690_abnormal_glial_cell1.35972386
57MP0008260_abnormal_autophagy1.34820157
58MP0003631_nervous_system_phenotype1.30444593
59MP0000026_abnormal_inner_ear1.28942784
60MP0001485_abnormal_pinna_reflex1.28399553
61MP0003634_abnormal_glial_cell1.27863520
62MP0001963_abnormal_hearing_physiology1.26089013
63MP0000631_abnormal_neuroendocrine_gland1.24745013
64MP0002163_abnormal_gland_morphology1.23576216
65MP0000372_irregular_coat_pigmentation1.20552901
66MP0008569_lethality_at_weaning1.17092976
67MP0000604_amyloidosis1.15850156
68MP0000955_abnormal_spinal_cord1.14533952
69MP0002882_abnormal_neuron_morphology1.13770629
70MP0002909_abnormal_adrenal_gland1.13586852
71MP0001346_abnormal_lacrimal_gland1.13273902
72MP0005174_abnormal_tail_pigmentation1.12285157
73MP0005394_taste/olfaction_phenotype1.11255834
74MP0005499_abnormal_olfactory_system1.11255834
75MP0003172_abnormal_lysosome_physiology1.10584398
76MP0002822_catalepsy1.10054730
77MP0005386_behavior/neurological_phenoty1.09170130
78MP0004924_abnormal_behavior1.09170130
79MP0002752_abnormal_somatic_nervous1.08055013
80MP0000920_abnormal_myelination1.05945300
81MP0003938_abnormal_ear_development1.04509622
82MP0003075_altered_response_to1.04223702
83MP0003121_genomic_imprinting0.99957067
84MP0008789_abnormal_olfactory_epithelium0.99391972
85MP0002066_abnormal_motor_capabilities/c0.99241771
86MP0006072_abnormal_retinal_apoptosis0.98644912
87MP0005623_abnormal_meninges_morphology0.97236672
88MP0002229_neurodegeneration0.96521358
89MP0000678_abnormal_parathyroid_gland0.95126471
90MP0003632_abnormal_nervous_system0.92234606
91MP0001664_abnormal_digestion0.91367343
92MP0003879_abnormal_hair_cell0.89590096
93MP0000681_abnormal_thyroid_gland0.88039573
94MP0002751_abnormal_autonomic_nervous0.87891874
95MP0003283_abnormal_digestive_organ0.87043549
96MP0001299_abnormal_eye_distance/0.84105430
97MP0008874_decreased_physiological_sensi0.84013477
98MP0005084_abnormal_gallbladder_morpholo0.82878880
99MP0004885_abnormal_endolymph0.82668987
100MP0005253_abnormal_eye_physiology0.82342519
101MP0002177_abnormal_outer_ear0.81295400
102MP0000049_abnormal_middle_ear0.78587629
103MP0002089_abnormal_postnatal_growth/wei0.78567354
104MP0002095_abnormal_skin_pigmentation0.75856136
105MP0008995_early_reproductive_senescence0.74769260
106MP0004145_abnormal_muscle_electrophysio0.74583700
107MP0002152_abnormal_brain_morphology0.70783867
108MP0004811_abnormal_neuron_physiology0.70281915
109MP0001177_atelectasis0.70158367
110MP0004858_abnormal_nervous_system0.70022116
111MP0002938_white_spotting0.66580017
112MP0003724_increased_susceptibility_to0.63753073
113MP0000639_abnormal_adrenal_gland0.63614206
114MP0000579_abnormal_nail_morphology0.63547112
115MP0002069_abnormal_eating/drinking_beha0.63468480
116MP0002160_abnormal_reproductive_system0.62726548
117MP0003941_abnormal_skin_development0.62667926
118MP0003861_abnormal_nervous_system0.61494960
119MP0005535_abnormal_body_temperature0.61265055
120MP0003122_maternal_imprinting0.59960276
121MP0005195_abnormal_posterior_eye0.58958713
122MP0005167_abnormal_blood-brain_barrier0.58819526
123MP0004043_abnormal_pH_regulation0.57428075
124MP0005075_abnormal_melanosome_morpholog0.54650122
125MP0009780_abnormal_chondrocyte_physiolo0.54539378
126MP0004130_abnormal_muscle_cell0.53719177
127MP0002090_abnormal_vision0.53717483
128MP0003137_abnormal_impulse_conducting0.53651715
129MP0010769_abnormal_survival0.53149074
130MP0001943_abnormal_respiration0.52006807
131MP0005058_abnormal_lysosome_morphology0.51774293
132MP0002082_postnatal_lethality0.51325829
133MP0010770_preweaning_lethality0.51325829
134MP0003956_abnormal_body_size0.50125012
135MP0010768_mortality/aging0.49153431
136MP0001731_abnormal_postnatal_growth0.45959489

Predicted human phenotypes

RankGene SetZ-score
1Supranuclear gaze palsy (HP:0000605)5.18151996
2Focal motor seizures (HP:0011153)5.17639116
3Action tremor (HP:0002345)4.68835909
4Febrile seizures (HP:0002373)4.50861515
5Ankle clonus (HP:0011448)4.45000162
6Neurofibrillary tangles (HP:0002185)4.31477412
7Diplopia (HP:0000651)4.03016969
8Abnormality of binocular vision (HP:0011514)4.03016969
9Visual hallucinations (HP:0002367)3.85317498
10Spastic gait (HP:0002064)3.70991037
11Cerebral inclusion bodies (HP:0100314)3.67012261
12Torticollis (HP:0000473)3.40671518
13Annular pancreas (HP:0001734)3.40000272
14Mutism (HP:0002300)3.23325388
15Urinary bladder sphincter dysfunction (HP:0002839)3.22515160
16Truncal ataxia (HP:0002078)3.22312052
17Abnormal eating behavior (HP:0100738)3.20357694
18Dysmetria (HP:0001310)3.15504824
19Septo-optic dysplasia (HP:0100842)3.14439015
20Focal dystonia (HP:0004373)3.13969604
21Cerebral hypomyelination (HP:0006808)3.11275799
22Intention tremor (HP:0002080)3.09912035
23Obstructive sleep apnea (HP:0002870)3.07798725
24Epileptic encephalopathy (HP:0200134)3.02066813
25Akinesia (HP:0002304)2.99611389
26Depression (HP:0000716)2.99128390
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.97918588
28Urinary urgency (HP:0000012)2.97341871
29Neuronal loss in central nervous system (HP:0002529)2.93584491
30Insomnia (HP:0100785)2.91405224
31Hypothermia (HP:0002045)2.90998405
32Craniofacial dystonia (HP:0012179)2.88414193
33Impaired vibration sensation in the lower limbs (HP:0002166)2.86369226
34Medial flaring of the eyebrow (HP:0010747)2.84558728
35Epileptiform EEG discharges (HP:0011182)2.84291581
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.82350034
37Absent/shortened dynein arms (HP:0200106)2.82350034
38Tetraplegia (HP:0002445)2.77673585
39Distal upper limb amyotrophy (HP:0007149)2.76016664
40Upper limb amyotrophy (HP:0009129)2.76016664
41Parakeratosis (HP:0001036)2.75414363
42Apathy (HP:0000741)2.75401527
43Myokymia (HP:0002411)2.72033561
44Delusions (HP:0000746)2.70949180
45Hand muscle atrophy (HP:0009130)2.66649854
46Focal seizures (HP:0007359)2.66310398
47Amblyopia (HP:0000646)2.65732422
48Status epilepticus (HP:0002133)2.63603208
49Abnormality of the lower motor neuron (HP:0002366)2.62501178
50Abnormality of the corticospinal tract (HP:0002492)2.62328675
51Anxiety (HP:0000739)2.61397255
52EEG with generalized epileptiform discharges (HP:0011198)2.60007823
53Gait imbalance (HP:0002141)2.58625374
54Optic nerve hypoplasia (HP:0000609)2.58074449
55Broad-based gait (HP:0002136)2.57589609
56Atonic seizures (HP:0010819)2.57184225
57Diminished motivation (HP:0000745)2.57154452
58Absent septum pellucidum (HP:0001331)2.56570237
59Progressive cerebellar ataxia (HP:0002073)2.56138363
60Hyperventilation (HP:0002883)2.54406092
61Clonus (HP:0002169)2.52894676
62Postural instability (HP:0002172)2.48652632
63Peripheral hypomyelination (HP:0007182)2.46887825
64Abnormal ciliary motility (HP:0012262)2.45693539
65Congenital sensorineural hearing impairment (HP:0008527)2.45430695
66Poor eye contact (HP:0000817)2.42355889
67Nephrogenic diabetes insipidus (HP:0009806)2.42156031
68Bradykinesia (HP:0002067)2.41661827
69Sleep apnea (HP:0010535)2.41113343
70Hypsarrhythmia (HP:0002521)2.39526005
71Limb dystonia (HP:0002451)2.37028962
72Congenital primary aphakia (HP:0007707)2.36574272
73True hermaphroditism (HP:0010459)2.35788184
74Decreased central vision (HP:0007663)2.35458915
75Chromsome breakage (HP:0040012)2.35232038
76Lower limb muscle weakness (HP:0007340)2.34577027
77Spastic tetraparesis (HP:0001285)2.32604703
78Split foot (HP:0001839)2.31606943
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.29690298
80Type I transferrin isoform profile (HP:0003642)2.27947046
81Patchy hypopigmentation of hair (HP:0011365)2.27938610
82Abnormality of the septum pellucidum (HP:0007375)2.27900493
83Fair hair (HP:0002286)2.23154542
84Protruding tongue (HP:0010808)2.22897574
85Gaze-evoked nystagmus (HP:0000640)2.22688412
86Aplasia/Hypoplasia of the fovea (HP:0008060)2.22622434
87Hypoplasia of the fovea (HP:0007750)2.22622434
88Absent speech (HP:0001344)2.21696400
89Abnormal respiratory motile cilium morphology (HP:0005938)2.21016666
90Abnormal respiratory epithelium morphology (HP:0012253)2.21016666
91Rigidity (HP:0002063)2.20515213
92Generalized hypopigmentation of hair (HP:0011358)2.20505391
93Aplasia/Hypoplasia of the lens (HP:0008063)2.20304729
94Nonprogressive disorder (HP:0003680)2.18815177
95Renal Fanconi syndrome (HP:0001994)2.18258844
96Polyphagia (HP:0002591)2.17274080
97Abnormal hair whorl (HP:0010721)2.15605408
98Lower limb amyotrophy (HP:0007210)2.14410037
99Blue irides (HP:0000635)2.13410061
100Duplicated collecting system (HP:0000081)2.13334636
101Turricephaly (HP:0000262)2.12775765
102Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12077100
103Hemiparesis (HP:0001269)2.12049791
104White forelock (HP:0002211)2.11857352
105Choreoathetosis (HP:0001266)2.11081189
106Fetal akinesia sequence (HP:0001989)2.10192099
107Attenuation of retinal blood vessels (HP:0007843)2.09603551
108Optic disc pallor (HP:0000543)2.09577346
109Abnormal social behavior (HP:0012433)2.09248255
110Impaired social interactions (HP:0000735)2.09248255
111Hyperacusis (HP:0010780)2.08575394
112Generalized tonic-clonic seizures (HP:0002069)2.07905937
113Vaginal atresia (HP:0000148)2.07261472
114Abnormal respiratory motile cilium physiology (HP:0012261)2.07185864
115Genital tract atresia (HP:0001827)2.06377197
116Abnormality of calcium-phosphate metabolism (HP:0100530)2.05506262
117Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05267254
118Osteomalacia (HP:0002749)2.04600044
119CNS hypomyelination (HP:0003429)2.04232077
120Esotropia (HP:0000565)2.03982279
121Impaired smooth pursuit (HP:0007772)2.03706720
122Abnormality of the renal collecting system (HP:0004742)2.03320595
123Hypomagnesemia (HP:0002917)2.00355800
124Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99538291
125Rapidly progressive (HP:0003678)1.98311255
126Papilledema (HP:0001085)1.97817331
127Retinal dysplasia (HP:0007973)1.97715964
128Abnormality of magnesium homeostasis (HP:0004921)1.95511211
129Bronchomalacia (HP:0002780)1.95414336
130Aplasia involving bones of the extremities (HP:0009825)1.94871536
131Aplasia involving bones of the upper limbs (HP:0009823)1.94871536
132Aplasia of the phalanges of the hand (HP:0009802)1.94871536
133Increased hepatocellular lipid droplets (HP:0006565)1.93168910
134Pointed chin (HP:0000307)1.92292096
135Anomalous pulmonary venous return (HP:0010772)1.90960795
136Dysdiadochokinesis (HP:0002075)1.88625319
137Abnormality of the axillary hair (HP:0100134)1.87815415
138Abnormality of secondary sexual hair (HP:0009888)1.87815415
139Incomplete penetrance (HP:0003829)1.87784695
140Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.87607317
1413-Methylglutaconic aciduria (HP:0003535)1.87294062
142Abnormality of incisor morphology (HP:0011063)1.87175286
143Submucous cleft hard palate (HP:0000176)1.86099450
144Atelectasis (HP:0100750)1.85906855
145Impaired vibratory sensation (HP:0002495)1.85888090
146Aplasia/hypoplasia of the uterus (HP:0008684)1.82391360
147Pancreatic fibrosis (HP:0100732)1.81995392
148Severe visual impairment (HP:0001141)1.81611748
149Sex reversal (HP:0012245)1.80582804
150Abnormal sex determination (HP:0012244)1.80582804
151Spastic tetraplegia (HP:0002510)1.79707733
152Duplication of thumb phalanx (HP:0009942)1.79616512
153Megalencephaly (HP:0001355)1.79488244
154Dialeptic seizures (HP:0011146)1.79343935
155Aplasia/Hypoplasia of the tibia (HP:0005772)1.77465925
156Stereotypic behavior (HP:0000733)1.77244529
157Dementia (HP:0000726)1.77000353
158Inability to walk (HP:0002540)1.76853116
159Abnormality of renal resorption (HP:0011038)1.76801070
160Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76793800
161Degeneration of the lateral corticospinal tracts (HP:0002314)1.76793800
162Agitation (HP:0000713)1.75867914
163Abnormality of the fovea (HP:0000493)1.75539583
164Distal sensory impairment (HP:0002936)1.75414406
165Hammertoe (HP:0001765)1.74372346
166Tubulointerstitial nephritis (HP:0001970)1.73867781
167Morphological abnormality of the pyramidal tract (HP:0002062)1.72410496
168Aganglionic megacolon (HP:0002251)1.71704076
169Abnormal rod and cone electroretinograms (HP:0008323)1.71103065
170Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.70943412
171Hemiplegia (HP:0002301)1.70471674
172Absence seizures (HP:0002121)1.69400319
173Abnormality of ocular smooth pursuit (HP:0000617)1.69298491
174Preaxial hand polydactyly (HP:0001177)1.69228694
175Nuclear cataract (HP:0100018)1.68951033
176Short tibia (HP:0005736)1.68709410
177Cortical visual impairment (HP:0100704)1.66661468
178Thyroid-stimulating hormone excess (HP:0002925)1.66546098
179Male pseudohermaphroditism (HP:0000037)1.66524335
180Molar tooth sign on MRI (HP:0002419)1.66356210
181Abnormality of midbrain morphology (HP:0002418)1.66356210
182Scanning speech (HP:0002168)1.64649132
183Gastroesophageal reflux (HP:0002020)1.64476506
184Overriding aorta (HP:0002623)1.63437893
185Spinal canal stenosis (HP:0003416)1.62276348
186Hypoventilation (HP:0002791)1.61622602
187Slow progression (HP:0003677)1.61015152
188Poor suck (HP:0002033)1.60276254

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.99055254
2TNIK3.12012937
3MAP2K72.92728117
4PRKD32.90299889
5MAP3K92.82647754
6EPHA42.59581274
7NTRK32.51044417
8CAMKK12.42614432
9MAPK132.23594261
10MKNK22.19037133
11MUSK2.17631949
12INSRR2.06054899
13STK162.02602876
14MARK11.92641771
15BMPR21.90832533
16ADRBK21.86732361
17LATS21.85203632
18BMPR1B1.81058734
19IRAK31.66224714
20PKN11.64559886
21RIPK11.60809226
22IRAK21.52783811
23TNK21.52695547
24PRPF4B1.52010794
25MAP3K111.50482664
26FES1.48530670
27IRAK41.47581268
28DAPK11.45460288
29MAP3K121.44864236
30RIPK41.43983044
31MKNK11.39970000
32NEK61.37102862
33LIMK11.35831645
34PNCK1.33193100
35PHKG21.32892671
36PHKG11.32892671
37TXK1.32059061
38BLK1.28700932
39TYRO31.27285755
40GRK71.25207895
41OXSR11.22245800
42TESK11.21336721
43ICK1.19231851
44ZAK1.17910674
45NME11.16057750
46AKT31.14359566
47UHMK11.14096694
48CDK151.13205538
49EIF2AK21.10907248
50YES11.10565479
51CAMK2B1.09950549
52NTRK21.09894208
53CDK181.08970486
54LMTK21.08866519
55BRSK11.08010478
56IRAK11.07838152
57STK391.07677155
58SGK4941.07012304
59SGK2231.07012304
60CDK141.06426757
61MAP3K41.05475016
62CDK31.04674072
63CDK11A1.03810517
64MAPKAPK51.02426231
65TRIB31.01881371
66PRKCH1.00013680
67SIK30.99964955
68SGK20.96887569
69CAMK10.96537754
70GRK50.94799771
71CAMK2A0.93782374
72MAP3K140.92932656
73PRKCE0.91781983
74MAP2K40.90381723
75PAK30.90117981
76KSR20.87414503
77SIK20.86867977
78ALK0.86600997
79DYRK1A0.85949933
80TLK10.84306558
81GRK10.83346173
82DAPK30.82463002
83MINK10.81507136
84STK110.80957249
85PRKD20.79866851
86PINK10.79836081
87PLK20.79161744
88CLK10.77847147
89TEC0.75646405
90BRD40.74620099
91CAMK2D0.73264314
92PDPK10.72342197
93SRPK10.71898537
94CDK190.71070027
95CDK50.70320555
96PRKCG0.68245635
97MAPK120.66739086
98SIK10.66527178
99BCR0.65554050
100PTK20.62983816
101PRKG20.59640805
102FGFR20.59186148
103CAMK1D0.58833167
104PDK10.57605179
105EIF2AK30.56403605
106SGK30.55898444
107FGR0.55500611
108MARK20.54885180
109MAPK100.54844673
110PRKCZ0.54641060
111BRAF0.54075127
112DYRK20.54018030
113WNK40.53559669
114MAP2K60.52693116
115VRK10.51997124
116PRKG10.51978579
117NLK0.51079816
118CAMK40.50862392
119CAMK2G0.50679829
120CAMK1G0.50380455
121HIPK20.49444372
122KSR10.48324757
123RPS6KA20.46805594
124MAP3K10.46442491
125PRKCQ0.46252995
126RPS6KA30.45847905
127PRKACA0.45532338
128PDGFRA0.45436651
129SGK10.45373863
130MAPK150.44497484
131PBK0.44138528
132WNK10.43649087
133CSNK1A1L0.43138155
134ADRBK10.42638757
135CSNK1A10.42540218
136PIM20.42134842
137CSNK1G30.41181756
138PRKCI0.39833309
139EPHA20.39650901
140TAOK10.39493648
141MAP3K20.38666784
142ARAF0.38090861
143CSNK1G10.37864766
144DDR20.37316271
145CSNK1E0.35379802
146WNK30.35283624
147TAOK20.35124650
148DAPK20.34567026
149PAK60.34462733
150CSNK1G20.34374316
151LYN0.34179552
152NTRK10.34139945
153STK380.33367772
154CAMKK20.31743085

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.71902484
2Morphine addiction_Homo sapiens_hsa050322.47242653
3Taste transduction_Homo sapiens_hsa047422.46434571
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40586149
5Phototransduction_Homo sapiens_hsa047442.29635846
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.29585760
7Glutamatergic synapse_Homo sapiens_hsa047242.28216595
8GABAergic synapse_Homo sapiens_hsa047272.12623647
9Serotonergic synapse_Homo sapiens_hsa047262.11002586
10Vitamin B6 metabolism_Homo sapiens_hsa007502.02683413
11Olfactory transduction_Homo sapiens_hsa047401.98335500
12Circadian entrainment_Homo sapiens_hsa047131.96470759
13Synaptic vesicle cycle_Homo sapiens_hsa047211.86609979
14Oxidative phosphorylation_Homo sapiens_hsa001901.83241779
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81352652
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75495075
17Ether lipid metabolism_Homo sapiens_hsa005651.65275898
18Amphetamine addiction_Homo sapiens_hsa050311.59856638
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58727449
20Salivary secretion_Homo sapiens_hsa049701.58534463
21Insulin secretion_Homo sapiens_hsa049111.58294220
22Collecting duct acid secretion_Homo sapiens_hsa049661.50621902
23Long-term depression_Homo sapiens_hsa047301.47793653
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.44054712
25Protein export_Homo sapiens_hsa030601.40747866
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40589110
27Calcium signaling pathway_Homo sapiens_hsa040201.36009428
28Cholinergic synapse_Homo sapiens_hsa047251.33167706
29Dopaminergic synapse_Homo sapiens_hsa047281.32487538
30Long-term potentiation_Homo sapiens_hsa047201.32063585
31Arachidonic acid metabolism_Homo sapiens_hsa005901.30228537
32Cocaine addiction_Homo sapiens_hsa050301.29482441
33Sphingolipid metabolism_Homo sapiens_hsa006001.27144190
34Alzheimers disease_Homo sapiens_hsa050101.26878126
35Linoleic acid metabolism_Homo sapiens_hsa005911.25771133
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25483416
37Fanconi anemia pathway_Homo sapiens_hsa034601.19571420
38Axon guidance_Homo sapiens_hsa043601.18168691
39Autoimmune thyroid disease_Homo sapiens_hsa053201.15841159
40Parkinsons disease_Homo sapiens_hsa050121.15194271
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14851271
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12427493
43Glioma_Homo sapiens_hsa052141.12265944
44Rheumatoid arthritis_Homo sapiens_hsa053231.10578020
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10568228
46Renin secretion_Homo sapiens_hsa049241.08693751
47Estrogen signaling pathway_Homo sapiens_hsa049151.08645175
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06368692
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05508526
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05083806
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04700681
52Type I diabetes mellitus_Homo sapiens_hsa049401.01670448
53Prion diseases_Homo sapiens_hsa050201.00104791
54Vibrio cholerae infection_Homo sapiens_hsa051101.00078794
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99435891
56Graft-versus-host disease_Homo sapiens_hsa053320.97808878
57ErbB signaling pathway_Homo sapiens_hsa040120.97363879
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96871145
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93754265
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.91731888
61Gastric acid secretion_Homo sapiens_hsa049710.90657944
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90437836
63Allograft rejection_Homo sapiens_hsa053300.88567552
64Thyroid hormone synthesis_Homo sapiens_hsa049180.88378570
65Huntingtons disease_Homo sapiens_hsa050160.85774684
66cAMP signaling pathway_Homo sapiens_hsa040240.85137076
67VEGF signaling pathway_Homo sapiens_hsa043700.83698303
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.82600145
69Oxytocin signaling pathway_Homo sapiens_hsa049210.81701316
70Bile secretion_Homo sapiens_hsa049760.80425437
71Cardiac muscle contraction_Homo sapiens_hsa042600.77737676
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77021831
73Ovarian steroidogenesis_Homo sapiens_hsa049130.75897034
74Type II diabetes mellitus_Homo sapiens_hsa049300.73939662
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73733491
76Asthma_Homo sapiens_hsa053100.73109766
77Oocyte meiosis_Homo sapiens_hsa041140.73079842
78Regulation of autophagy_Homo sapiens_hsa041400.72329438
79Other glycan degradation_Homo sapiens_hsa005110.72012818
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70199755
81Fatty acid elongation_Homo sapiens_hsa000620.69482027
82Melanogenesis_Homo sapiens_hsa049160.69436234
83Arginine and proline metabolism_Homo sapiens_hsa003300.68128126
84Pancreatic secretion_Homo sapiens_hsa049720.67099285
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.66864620
86GnRH signaling pathway_Homo sapiens_hsa049120.66857022
87Ras signaling pathway_Homo sapiens_hsa040140.64612325
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63799770
89Endocytosis_Homo sapiens_hsa041440.62514065
90Homologous recombination_Homo sapiens_hsa034400.61789782
91Fatty acid biosynthesis_Homo sapiens_hsa000610.61667007
92Rap1 signaling pathway_Homo sapiens_hsa040150.60179081
93Gap junction_Homo sapiens_hsa045400.59990161
94Glucagon signaling pathway_Homo sapiens_hsa049220.59496634
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58060782
96Purine metabolism_Homo sapiens_hsa002300.57326872
97Steroid biosynthesis_Homo sapiens_hsa001000.56451075
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.55546238
99Wnt signaling pathway_Homo sapiens_hsa043100.55025141
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52529398
101African trypanosomiasis_Homo sapiens_hsa051430.52113988
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50887353
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50702155
104Inositol phosphate metabolism_Homo sapiens_hsa005620.50534529
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.50529556
106Basal transcription factors_Homo sapiens_hsa030220.50024545
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49780034
108RNA polymerase_Homo sapiens_hsa030200.49527924
109Arginine biosynthesis_Homo sapiens_hsa002200.49383958
110mTOR signaling pathway_Homo sapiens_hsa041500.48766105
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48489328
112Alcoholism_Homo sapiens_hsa050340.47940719
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47820916
114MAPK signaling pathway_Homo sapiens_hsa040100.47581737
115AMPK signaling pathway_Homo sapiens_hsa041520.45691086
116Choline metabolism in cancer_Homo sapiens_hsa052310.45420737
117Dilated cardiomyopathy_Homo sapiens_hsa054140.45346961
118Circadian rhythm_Homo sapiens_hsa047100.45307415
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45082957
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44159224
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44017847
122Phagosome_Homo sapiens_hsa041450.43179101
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.42060937
124Chemokine signaling pathway_Homo sapiens_hsa040620.41956534
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41272363
126Primary immunodeficiency_Homo sapiens_hsa053400.41206368
127Insulin signaling pathway_Homo sapiens_hsa049100.40494069
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39687040
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39321275
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38926731
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38747000
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.38440501
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37895252
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.34721416
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34708755
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33700616
137Histidine metabolism_Homo sapiens_hsa003400.32244476
138Mineral absorption_Homo sapiens_hsa049780.31106439
139Hippo signaling pathway_Homo sapiens_hsa043900.31073295
140Fructose and mannose metabolism_Homo sapiens_hsa000510.29791539
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29773224
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.29189005
143Lysosome_Homo sapiens_hsa041420.28032073
144Tight junction_Homo sapiens_hsa045300.27807786

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »