ASPN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis, and also with intervertebral disc disease. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)9.90719711
2collagen fibril organization (GO:0030199)7.89496350
3extracellular fibril organization (GO:0043206)7.63050576
4peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)7.03532191
5keratan sulfate catabolic process (GO:0042340)7.03395478
6dermatan sulfate biosynthetic process (GO:0030208)6.59498059
7fibril organization (GO:0097435)6.56879509
8bone trabecula formation (GO:0060346)6.49683789
9cell migration involved in heart development (GO:0060973)6.24729185
10sequestering of extracellular ligand from receptor (GO:0035581)6.16724851
11dermatan sulfate metabolic process (GO:0030205)6.04390423
12negative regulation of heart growth (GO:0061117)5.78910283
13negative regulation of cardiac muscle tissue growth (GO:0055022)5.78910283
14negative regulation of gluconeogenesis (GO:0045721)5.62060429
15skin morphogenesis (GO:0043589)5.28818336
16positive regulation of osteoblast proliferation (GO:0033690)5.19770350
17collagen metabolic process (GO:0032963)5.17398308
18collagen catabolic process (GO:0030574)5.02154298
19chondrocyte proliferation (GO:0035988)4.98798961
20regulation of cardioblast differentiation (GO:0051890)4.89331632
21multicellular organismal macromolecule metabolic process (GO:0044259)4.86643948
22negative regulation of cartilage development (GO:0061037)4.86308256
23regulation of cardioblast proliferation (GO:0003264)4.86046141
24regulation of secondary heart field cardioblast proliferation (GO:0003266)4.86046141
25endodermal cell differentiation (GO:0035987)4.76134103
26pericardium development (GO:0060039)4.66406931
27negative regulation of chemokine production (GO:0032682)4.63090702
28multicellular organismal catabolic process (GO:0044243)4.62861191
29multicellular organismal metabolic process (GO:0044236)4.61819374
30metanephric mesenchyme development (GO:0072075)4.58827820
31negative regulation of cardiac muscle tissue development (GO:0055026)4.33238376
32kidney mesenchyme development (GO:0072074)4.30175082
33extracellular matrix disassembly (GO:0022617)4.26286616
34regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.20008753
35intestinal epithelial cell development (GO:0060576)4.18202105
36negative regulation of NF-kappaB import into nucleus (GO:0042347)4.14788303
37phosphate ion homeostasis (GO:0055062)4.13801277
38trivalent inorganic anion homeostasis (GO:0072506)4.13801277
39positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr4.12267172
40regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.10883133
41negative regulation of complement activation (GO:0045916)4.03465825
42chondroitin sulfate catabolic process (GO:0030207)4.01887793
43endocardial cushion morphogenesis (GO:0003203)3.99760992
44glomerulus development (GO:0032835)3.98407021
45endocardial cushion development (GO:0003197)3.91737421
46regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.90926193
47extracellular regulation of signal transduction (GO:1900115)3.86871147
48extracellular negative regulation of signal transduction (GO:1900116)3.86871147
49replacement ossification (GO:0036075)3.81339623
50endochondral ossification (GO:0001958)3.81339623
51extracellular matrix assembly (GO:0085029)3.79154023
52prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.75066700
53lymph vessel development (GO:0001945)3.72434351
54opsonization (GO:0008228)3.72410099
55negative regulation of protein activation cascade (GO:2000258)3.70131090
56regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.66261806
57camera-type eye morphogenesis (GO:0048593)3.66241872
58extracellular matrix organization (GO:0030198)3.65053398
59extracellular structure organization (GO:0043062)3.63621454
60regulation of organ formation (GO:0003156)3.62756584
61retina vasculature morphogenesis in camera-type eye (GO:0061299)3.60121390
62chondroitin sulfate biosynthetic process (GO:0030206)3.57186650
63embryonic skeletal system development (GO:0048706)3.54153165
64protein trimerization (GO:0070206)3.53200687
65atrioventricular valve morphogenesis (GO:0003181)3.52995515
66inner ear receptor stereocilium organization (GO:0060122)3.52545211
67substrate-dependent cell migration (GO:0006929)3.49272617
68mesenchyme morphogenesis (GO:0072132)3.49022605
69smooth muscle tissue development (GO:0048745)3.47354848
70basement membrane organization (GO:0071711)3.45557967
71regulation of macrophage cytokine production (GO:0010935)3.45034286
72trabecula formation (GO:0060343)3.39792555
73regulation of smooth muscle cell apoptotic process (GO:0034391)3.38605543
74positive regulation of smooth muscle cell migration (GO:0014911)3.38534066
75axon extension involved in axon guidance (GO:0048846)3.37990959
76neuron projection extension involved in neuron projection guidance (GO:1902284)3.37990959
77adhesion of symbiont to host cell (GO:0044650)3.37909009
78virion attachment to host cell (GO:0019062)3.37909009
79outer ear morphogenesis (GO:0042473)3.36922658
80tooth mineralization (GO:0034505)3.36703274
81chondrocyte development (GO:0002063)3.36677852
82regulation of chondrocyte differentiation (GO:0032330)3.33812029
83positive regulation of macrophage cytokine production (GO:0060907)3.33429558
84organ formation (GO:0048645)3.31991677
85cell adhesion mediated by integrin (GO:0033627)3.30325402
86protein retention in ER lumen (GO:0006621)3.29384417
87endothelial cell morphogenesis (GO:0001886)3.29143818
88lung secretory cell differentiation (GO:0061140)3.26606636
89cartilage development (GO:0051216)3.24012692
90craniofacial suture morphogenesis (GO:0097094)3.23565020
91organ induction (GO:0001759)3.22780101
92positive regulation of blood vessel endothelial cell migration (GO:0043536)3.22268603
93gonadal mesoderm development (GO:0007506)3.21514607
94regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.18841473
95protein localization to cell surface (GO:0034394)3.18576998
96venous blood vessel morphogenesis (GO:0048845)3.17465152
97blood vessel maturation (GO:0001955)3.15678429
98keratan sulfate biosynthetic process (GO:0018146)3.14523668
99maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.14122278
100genitalia morphogenesis (GO:0035112)3.13200442
101glomerular basement membrane development (GO:0032836)3.13025119
102glomerular filtration (GO:0003094)3.10758067
103sulfur compound catabolic process (GO:0044273)3.09144911
104regulation of osteoblast proliferation (GO:0033688)3.08990814
105insulin-like growth factor receptor signaling pathway (GO:0048009)3.07526988
106peptidyl-proline hydroxylation (GO:0019511)3.06996557
107regulation of execution phase of apoptosis (GO:1900117)3.04896884
108glycosaminoglycan catabolic process (GO:0006027)3.03445864
109positive regulation of mesenchymal cell proliferation (GO:0002053)3.03044504
110cell aggregation (GO:0098743)3.02977472
111cartilage condensation (GO:0001502)3.02977472
112plasma membrane repair (GO:0001778)3.02951424
113regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.02125959
114prostate gland growth (GO:0060736)3.01491348
115regulation of establishment of planar polarity (GO:0090175)3.01054493
116Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.00914936
117positive regulation of glycogen biosynthetic process (GO:0045725)3.00751078
118vascular endothelial growth factor signaling pathway (GO:0038084)3.00146195
119negative regulation of humoral immune response (GO:0002921)2.98715446
120cellular response to amino acid stimulus (GO:0071230)2.98316466
121epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.98147833
122non-canonical Wnt signaling pathway (GO:0035567)2.95790394
123regulation of extracellular matrix disassembly (GO:0010715)2.95778971
124positive regulation of cardiac muscle cell proliferation (GO:0060045)2.95465058
125lung vasculature development (GO:0060426)2.95392242
126regulation of cardiac muscle tissue growth (GO:0055021)2.95175841
127exocrine pancreas development (GO:0031017)2.94450573
128positive regulation of epithelial to mesenchymal transition (GO:0010718)2.94185341
129negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.94015049
130cardiac ventricle formation (GO:0003211)2.93687052
131mesenchymal-epithelial cell signaling (GO:0060638)2.91962593
132ossification (GO:0001503)2.90096595
133establishment of planar polarity (GO:0001736)2.89765184
134establishment of tissue polarity (GO:0007164)2.89765184
135cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.89120875
136protein hydroxylation (GO:0018126)2.86401865
137embryonic cranial skeleton morphogenesis (GO:0048701)2.86365210
138artery development (GO:0060840)2.85659937
139regulation of mesenchymal cell proliferation (GO:0010464)2.85533502
140aminoglycan catabolic process (GO:0006026)2.82445082
141regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.81304127
142platelet-derived growth factor receptor signaling pathway (GO:0048008)2.78521360
143keratan sulfate metabolic process (GO:0042339)2.77979097
144cochlea morphogenesis (GO:0090103)2.77901137
145regulation of complement activation (GO:0030449)2.77446494
146regulation of cardiac muscle hypertrophy (GO:0010611)2.77266511
147negative regulation of chondrocyte differentiation (GO:0032331)2.76908371
148positive regulation of glycolytic process (GO:0045821)2.75915963
149positive regulation of endothelial cell apoptotic process (GO:2000353)2.75540404
150cellular response to vitamin (GO:0071295)2.75198408
151lung lobe morphogenesis (GO:0060463)2.75002822
152glycosaminoglycan biosynthetic process (GO:0006024)2.74150907
153peptide cross-linking (GO:0018149)2.73865234
154middle ear morphogenesis (GO:0042474)2.73477083
155regulation of cardiac muscle cell apoptotic process (GO:0010665)2.73098950

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.12764201
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.44263659
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.20541696
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.22560522
5WT1_19549856_ChIP-ChIP_CCG9911_Human3.14857541
6ESR1_22446102_ChIP-Seq_UTERUS_Mouse3.08263445
7* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.87855830
8* CJUN_26792858_Chip-Seq_BT549_Human2.85853044
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.75924558
10TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.73765334
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69933661
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.54659699
13CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.52399240
14CLOCK_20551151_ChIP-Seq_293T_Human2.50508125
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.44641972
16RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.34289155
17EP300_21415370_ChIP-Seq_HL-1_Mouse2.21572098
18NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.12200168
19NRF2_20460467_ChIP-Seq_MEFs_Mouse2.12200168
20BRD4_25478319_ChIP-Seq_HGPS_Human2.02381838
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.99400417
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.98669077
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.94931372
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.92806032
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92336015
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.89227579
27TP53_18474530_ChIP-ChIP_U2OS_Human1.84909050
28* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73344395
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.71787932
30AR_21572438_ChIP-Seq_LNCaP_Human1.71530267
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69690588
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68195396
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.67587321
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.67179965
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.66971928
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66730164
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61797601
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61797601
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61433426
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59619501
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.58313685
42GATA1_22025678_ChIP-Seq_K562_Human1.55995624
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55794439
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.52263839
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47318955
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.45057195
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.44535958
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41994372
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39443017
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.39179264
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.38939246
52SOX2_20726797_ChIP-Seq_SW620_Human1.37065078
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37038743
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.36906131
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36512683
56TP53_16413492_ChIP-PET_HCT116_Human1.35066133
57JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34567339
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33090062
59JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32939506
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31260821
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.30073215
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29584182
63TP53_20018659_ChIP-ChIP_R1E_Mouse1.26884470
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26531290
65SMC1_22415368_ChIP-Seq_MEFs_Mouse1.25490766
66P300_19829295_ChIP-Seq_ESCs_Human1.25421757
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25109789
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24823859
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23300365
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22952857
71TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.22941155
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22817327
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22492902
74GBX2_23144817_ChIP-Seq_PC3_Human1.22302969
75P53_22387025_ChIP-Seq_ESCs_Mouse1.21679393
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21360287
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.19341310
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18685228
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16225710
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14653658
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13648735
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13648735
83MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.13071888
84FUS_26573619_Chip-Seq_HEK293_Human1.12919897
85TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12475076
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11153866
87TBL1_22424771_ChIP-Seq_293T_Human1.10620727
88EZH2_27304074_Chip-Seq_ESCs_Mouse1.10290045
89JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10220934
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09294463
91FOXO3_23340844_ChIP-Seq_DLD1_Human1.09233942
92TBX20_22080862_ChIP-Seq_HEART_Mouse1.09036769
93TBX20_22328084_ChIP-Seq_HEART_Mouse1.09036769
94SA1_22415368_ChIP-Seq_MEFs_Mouse1.08906930
95KDM2B_26808549_Chip-Seq_REH_Human1.08534041
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07731591
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.07067127
98* CDX2_22108803_ChIP-Seq_LS180_Human1.06600184
99HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06505241
100MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06492187
101EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05733056
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04932177
103FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04109359
104RNF2_27304074_Chip-Seq_ESCs_Mouse1.03753341
105AHR_22903824_ChIP-Seq_MCF-7_Human1.03713406
106VDR_22108803_ChIP-Seq_LS180_Human1.03364208
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03150198
108OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03070680
109E2F1_18555785_Chip-Seq_ESCs_Mouse1.02735049
110* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01304333
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00233878
112ESR2_21235772_ChIP-Seq_MCF-7_Human0.99836627
113NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99347316
114SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98993409
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98904309
116LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98671146
117BCAT_22108803_ChIP-Seq_LS180_Human0.98512787
118ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98268993
119SALL1_21062744_ChIP-ChIP_HESCs_Human0.98052074
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97906404
121* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97448130
122TCF4_18268006_ChIP-ChIP_LS174T_Human0.97426061
123STAT3_18555785_Chip-Seq_ESCs_Mouse0.97295466
124HNFA_21074721_ChIP-Seq_CACO-2_Human0.97280508
125AR_25329375_ChIP-Seq_VCAP_Human0.96126216
126CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96078836
127ISL1_27105846_Chip-Seq_CPCs_Mouse0.96058071
128PHF8_20622853_ChIP-Seq_HELA_Human0.95389806
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95322863
130TP63_23658742_ChIP-Seq_EP156T_Human0.94886450
131VDR_24787735_ChIP-Seq_THP-1_Human0.94703473
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.94437759
133RXR_22108803_ChIP-Seq_LS180_Human0.94167929
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94127703
135HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94038861
136STAT3_23295773_ChIP-Seq_U87_Human0.93932889
137P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93223202
138UBF1/2_26484160_Chip-Seq_HMECs_Human0.89667676
139RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89006994
140EGR1_19374776_ChIP-ChIP_THP-1_Human0.88658033
141DROSHA_22980978_ChIP-Seq_HELA_Human0.88252009
142WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87682269
143PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.87516206
144JARID2_20064375_ChIP-Seq_MESCs_Mouse0.85887443
145CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84188333
146NFI_21473784_ChIP-Seq_ESCs_Mouse0.83466754
147SMAD4_21799915_ChIP-Seq_A2780_Human0.81995180
148NFIB_24661679_ChIP-Seq_LUNG_Mouse0.81439031
149NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81027582
150TP53_23651856_ChIP-Seq_MEFs_Mouse0.80716992
151SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.80065204
152RING1B_27294783_Chip-Seq_NPCs_Mouse0.78473284

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology8.02696339
2MP0005275_abnormal_skin_tensile7.37994850
3MP0001958_emphysema3.30500944
4MP0003279_aneurysm3.21472765
5MP0003705_abnormal_hypodermis_morpholog3.10758902
6MP0002060_abnormal_skin_morphology2.56924540
7MP0002108_abnormal_muscle_morphology2.55754555
8MP0004272_abnormal_basement_membrane2.54992412
9MP0005508_abnormal_skeleton_morphology2.38453867
10MP0009384_cardiac_valve_regurgitation2.33399933
11MP0006054_spinal_hemorrhage2.29658580
12MP0001542_abnormal_bone_strength2.07044563
13MP0008438_abnormal_cutaneous_collagen10.4235392
14MP0003566_abnormal_cell_adhesion1.83075548
15MP0009250_abnormal_appendicular_skeleto1.81373369
16MP0002254_reproductive_system_inflammat1.72916270
17MP0005257_abnormal_intraocular_pressure1.72097289
18MP0010368_abnormal_lymphatic_system1.70781636
19MP0002295_abnormal_pulmonary_circulatio1.64488377
20MP0005171_absent_coat_pigmentation1.64412854
21MP0004134_abnormal_chest_morphology1.59468588
22MP0005623_abnormal_meninges_morphology1.56329524
23MP0001243_abnormal_dermal_layer1.56125316
24MP0003283_abnormal_digestive_organ1.50221740
25MP0002896_abnormal_bone_mineralization1.37487324
26MP0005390_skeleton_phenotype1.35776945
27MP0000462_abnormal_digestive_system1.28163358
28MP0002282_abnormal_trachea_morphology1.24176605
29MP0000751_myopathy1.23043019
30MP0010030_abnormal_orbit_morphology1.21492491
31MP0003385_abnormal_body_wall1.18600084
32MP0002933_joint_inflammation1.17073872
33MP0005023_abnormal_wound_healing1.14611582
34MP0001879_abnormal_lymphatic_vessel1.10201368
35MP0002998_abnormal_bone_remodeling1.09291778
36MP0002115_abnormal_skeleton_extremities1.07875651
37MP0001299_abnormal_eye_distance/1.06964540
38MP0001348_abnormal_lacrimal_gland1.06067465
39MP0000013_abnormal_adipose_tissue1.04590124
40MP0000163_abnormal_cartilage_morphology1.03576109
41MP0002932_abnormal_joint_morphology1.03261219
42MP0000534_abnormal_ureter_morphology0.96623594
43MP0003091_abnormal_cell_migration0.95345762
44MP0002113_abnormal_skeleton_development0.95122346
45MP0000767_abnormal_smooth_muscle0.93623192
46MP0002168_other_aberrant_phenotype0.89205937
47MP0000733_abnormal_muscle_development0.88945016
48MP0003115_abnormal_respiratory_system0.85383977
49MP0005595_abnormal_vascular_smooth0.85073966
50MP0002876_abnormal_thyroid_physiology0.82406872
51MP0003795_abnormal_bone_structure0.81825295
52MP0000749_muscle_degeneration0.81679620
53MP0000428_abnormal_craniofacial_morphol0.81382473
54MP0005369_muscle_phenotype0.80504367
55MP0002837_dystrophic_cardiac_calcinosis0.80057982
56MP0001533_abnormal_skeleton_physiology0.78891551
57MP0000681_abnormal_thyroid_gland0.77170915
58MP0003045_fibrosis0.77027153
59MP0003252_abnormal_bile_duct0.75536239
60MP0000003_abnormal_adipose_tissue0.75291036
61MP0002249_abnormal_larynx_morphology0.73026407
62MP0003942_abnormal_urinary_system0.72689075
63MP0002128_abnormal_blood_circulation0.71903693
64MP0005388_respiratory_system_phenotype0.69228654
65MP0002133_abnormal_respiratory_system0.69228654
66MP0002109_abnormal_limb_morphology0.68885911
67MP0003448_altered_tumor_morphology0.67967135
68MP0010771_integument_phenotype0.67760139
69MP0000343_altered_response_to0.67321431
70MP0005164_abnormal_response_to0.67192665
71MP0000432_abnormal_head_morphology0.66924961
72MP0008260_abnormal_autophagy0.65302269
73MP0002116_abnormal_craniofacial_bone0.64201127
74MP0010386_abnormal_urinary_bladder0.64110106
75MP0005330_cardiomyopathy0.64079027
76MP0003755_abnormal_palate_morphology0.63820050
77MP0000049_abnormal_middle_ear0.63810443
78MP0003935_abnormal_craniofacial_develop0.63508347
79MP0004883_abnormal_blood_vessel0.62734428
80MP0001614_abnormal_blood_vessel0.59931870
81MP0002233_abnormal_nose_morphology0.59781284
82MP0002089_abnormal_postnatal_growth/wei0.59404719
83MP0001175_abnormal_lung_morphology0.58908784
84MP0006138_congestive_heart_failure0.58846458
85MP0000372_irregular_coat_pigmentation0.58796779
86MP0002877_abnormal_melanocyte_morpholog0.58517731
87MP0001177_atelectasis0.57768983
88MP0002009_preneoplasia0.56792463
89MP0004084_abnormal_cardiac_muscle0.56785782
90MP0000747_muscle_weakness0.56421604
91MP0009053_abnormal_anal_canal0.56238331
92MP0000762_abnormal_tongue_morphology0.55125249
93MP0000750_abnormal_muscle_regeneration0.54888627
94MP0009780_abnormal_chondrocyte_physiolo0.54062614
95MP0005193_abnormal_anterior_eye0.53616500
96MP0004185_abnormal_adipocyte_glucose0.53511495
97MP0005220_abnormal_exocrine_pancreas0.53411734
98MP0002102_abnormal_ear_morphology0.52141193
99MP0005408_hypopigmentation0.50913043
100MP0002925_abnormal_cardiovascular_devel0.50630788
101MP0000759_abnormal_skeletal_muscle0.49518178
102MP0004087_abnormal_muscle_fiber0.49154848
103MP0005620_abnormal_muscle_contractility0.47263169
104MP0004484_altered_response_of0.47102700
105MP0003724_increased_susceptibility_to0.46856937
106MP0002114_abnormal_axial_skeleton0.46816668
107MP0005253_abnormal_eye_physiology0.46721227
108MP0001544_abnormal_cardiovascular_syste0.46430844
109MP0005385_cardiovascular_system_phenoty0.46430844
110MP0001915_intracranial_hemorrhage0.46403098
111MP0005076_abnormal_cell_differentiation0.44808498
112MP0003937_abnormal_limbs/digits/tail_de0.43997815
113MP0003950_abnormal_plasma_membrane0.43375612
114MP0001661_extended_life_span0.42887843
115MP0000613_abnormal_salivary_gland0.40981136
116MP0001270_distended_abdomen0.40310375
117MP0004036_abnormal_muscle_relaxation0.38896950
118MP0003938_abnormal_ear_development0.36837467
119MP0002269_muscular_atrophy0.33894392
120MP0005165_increased_susceptibility_to0.32857860
121MP0000249_abnormal_blood_vessel0.31619104
122MP0004145_abnormal_muscle_electrophysio0.31135385
123MP0005248_abnormal_Harderian_gland0.29607311
124MP0002106_abnormal_muscle_physiology0.28058090
125MP0000604_amyloidosis0.27802960

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)9.92705853
2Premature rupture of membranes (HP:0001788)7.89628016
3Absent frontal sinuses (HP:0002688)7.67563371
4Metaphyseal dysplasia (HP:0100255)6.79316644
5Broad metatarsal (HP:0001783)5.92334808
6Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)5.89929914
7Aortic dissection (HP:0002647)5.39563170
8Ankle contracture (HP:0006466)5.14071372
9Metaphyseal cupping (HP:0003021)5.13677660
10Abnormality of the frontal sinuses (HP:0002687)4.97851524
11Soft skin (HP:0000977)4.90982759
12Shallow orbits (HP:0000586)4.81520365
13Neonatal short-limb short stature (HP:0008921)4.80250324
14Aplasia/Hypoplasia involving the sinuses (HP:0009120)4.74875565
15Follicular hyperkeratosis (HP:0007502)4.69655931
16Atrophic scars (HP:0001075)4.55087396
17Abnormality of dentin (HP:0010299)4.43530189
18Biconcave vertebral bodies (HP:0004586)4.43283478
19Bladder diverticulum (HP:0000015)4.26952875
20Aortic aneurysm (HP:0004942)4.26802454
21Type 1 muscle fiber predominance (HP:0003803)4.23160009
22Dilatation of the ascending aorta (HP:0005111)4.11957595
23Hypoplastic ischia (HP:0003175)4.09281157
24Peritonitis (HP:0002586)3.96706154
25Aplasia of the musculature (HP:0100854)3.94288366
26Fragile skin (HP:0001030)3.88086254
27Cerebral aneurysm (HP:0004944)3.83493164
28Wormian bones (HP:0002645)3.82071846
29Mitral valve prolapse (HP:0001634)3.81247119
30Genu recurvatum (HP:0002816)3.78568549
31Arthropathy (HP:0003040)3.72432437
32Abnormality of the ischium (HP:0003174)3.68261543
33Spinal rigidity (HP:0003306)3.62736028
34Persistence of primary teeth (HP:0006335)3.58546146
35Cupped ribs (HP:0000887)3.51293626
36Blue sclerae (HP:0000592)3.49486438
37Slender build (HP:0001533)3.49315268
38Ulnar bowing (HP:0003031)3.47584824
39Vertebral compression fractures (HP:0002953)3.41537287
40Spondylolisthesis (HP:0003302)3.41524404
41Long clavicles (HP:0000890)3.37898816
42Vitreoretinal degeneration (HP:0000655)3.34850054
43Cervical subluxation (HP:0003308)3.32487732
44Increased connective tissue (HP:0009025)3.31421664
45Partial duplication of the phalanx of hand (HP:0009999)3.26980150
46Subacute progressive viral hepatitis (HP:0006572)3.24807735
47Abnormal delivery (HP:0001787)3.24706050
48Irregular vertebral endplates (HP:0003301)3.18394416
49Hyperextensible skin (HP:0000974)3.14005931
50Distal arthrogryposis (HP:0005684)3.11635705
51Enlarged epiphyses (HP:0010580)3.01355179
52Mildly elevated creatine phosphokinase (HP:0008180)2.98792946
53Round ear (HP:0100830)2.94950410
54Mitral regurgitation (HP:0001653)2.93887150
55Anomalous pulmonary venous return (HP:0010772)2.92459553
56Thin bony cortex (HP:0002753)2.87602292
57Radial bowing (HP:0002986)2.84832906
58Coxa vara (HP:0002812)2.82053145
59Vascular tortuosity (HP:0004948)2.79579008
60Short middle phalanx of the 5th finger (HP:0004220)2.76712473
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.74644855
62Osteolytic defects of the hand bones (HP:0009699)2.74644855
63Increased variability in muscle fiber diameter (HP:0003557)2.71245947
64Bowel diverticulosis (HP:0005222)2.71007535
65Broad ribs (HP:0000885)2.69147803
66Wide anterior fontanel (HP:0000260)2.68496223
67Ectopia lentis (HP:0001083)2.67988148
68Abnormality of the acetabulum (HP:0003170)2.67003839
69Breech presentation (HP:0001623)2.66012387
70Partial duplication of thumb phalanx (HP:0009944)2.64415546
71Striae distensae (HP:0001065)2.62686911
72Joint laxity (HP:0001388)2.62268080
73Aortic regurgitation (HP:0001659)2.61583931
74Systemic lupus erythematosus (HP:0002725)2.60017324
75Keratoconus (HP:0000563)2.56854243
76Increased corneal curvature (HP:0100692)2.56854243
77Abnormality of the pulmonary veins (HP:0011718)2.55263495
78Overgrowth (HP:0001548)2.54686313
79Ulnar claw (HP:0001178)2.52115668
80Elbow flexion contracture (HP:0002987)2.50518067
81Wrist flexion contracture (HP:0001239)2.46027324
82Mild short stature (HP:0003502)2.40634224
83Mitral stenosis (HP:0001718)2.40386244
84Abnormality of the phalanges of the 2nd finger (HP:0009541)2.40236120
85Disproportionate tall stature (HP:0001519)2.38148469
86Abnormality of skeletal muscle fiber size (HP:0012084)2.36790252
87Nonimmune hydrops fetalis (HP:0001790)2.36733603
88Patent foramen ovale (HP:0001655)2.35402559
89Osteoarthritis (HP:0002758)2.34627530
90Abnormality of the vertebral endplates (HP:0005106)2.33756150
91Trismus (HP:0000211)2.32900778
92Flat cornea (HP:0007720)2.31888186
93Infantile muscular hypotonia (HP:0008947)2.30421999
94Abnormality of incisor morphology (HP:0011063)2.27058392
95Camptodactyly of toe (HP:0001836)2.25632937
96Genu varum (HP:0002970)2.23877693
97Morphological abnormality of the middle ear (HP:0008609)2.21729080
98Hypoplasia of the iris (HP:0007676)2.20933492
99Bell-shaped thorax (HP:0001591)2.20528960
100Aneurysm (HP:0002617)2.20254014
101Aplasia/Hypoplasia of the scapulae (HP:0006713)2.16778273
102Hypoplastic scapulae (HP:0000882)2.16778273
103Decreased skull ossification (HP:0004331)2.14280042
104Pulmonary artery stenosis (HP:0004415)2.11811855
105Aortic valve stenosis (HP:0001650)2.10987910
106Hypoplastic left heart (HP:0004383)2.10598012
107Venous abnormality (HP:0002624)2.10233101
108Alopecia of scalp (HP:0002293)2.08748400
109Femoral bowing (HP:0002980)2.06231484
110Joint stiffness (HP:0001387)2.05056112
111Osteopenia (HP:0000938)2.04260594
112Abnormality of primary teeth (HP:0006481)2.04165488
113Abnormality of complement system (HP:0005339)2.03127462
114Knee flexion contracture (HP:0006380)2.02822737
115Ulnar deviation of the wrist (HP:0003049)2.02043216
116Deviation of the hallux (HP:0010051)2.01804003
117Tibial bowing (HP:0002982)2.01673265
118Complement deficiency (HP:0004431)2.00944743
119Generalized amyotrophy (HP:0003700)2.00792809
120Hypoplastic heart (HP:0001961)2.00284320
121Venous insufficiency (HP:0005293)1.99876862
122Broad long bones (HP:0005622)1.99262525
123Short middle phalanx of finger (HP:0005819)1.98688702
124Narrow palate (HP:0000189)1.97459674
125Fibular hypoplasia (HP:0003038)1.96644430
126Abnormality of the anterior chamber (HP:0000593)1.93379391
127Cardiovascular calcification (HP:0011915)1.91712880
128Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.91129332
129Hallux valgus (HP:0001822)1.90909699
130Aplasia/Hypoplasia involving the musculature (HP:0001460)1.90875459
131Coronal craniosynostosis (HP:0004440)1.90201102
132Abnormality of skull ossification (HP:0002703)1.89832455
133Platyspondyly (HP:0000926)1.88506795
134Short hallux (HP:0010109)1.88468129
135Arterial tortuosity (HP:0005116)1.88265051
136Inguinal hernia (HP:0000023)1.87357067
137Beaking of vertebral bodies (HP:0004568)1.86348420
138Delayed closure of the anterior fontanelle (HP:0001476)1.85570584
139Hip contracture (HP:0003273)1.84721289
140Narrow nasal bridge (HP:0000446)1.84684934
141Bowed forearm bones (HP:0003956)1.84571916
142Decreased subcutaneous fat (HP:0001002)1.83276776
143Esophageal neoplasm (HP:0100751)1.79522055
144Neoplasm of head and neck (HP:0012288)1.79522055
145Delayed cranial suture closure (HP:0000270)1.78680733
146Thin skin (HP:0000963)1.77055504
147Limited hip movement (HP:0008800)1.76536439
148Asymmetry of the thorax (HP:0001555)1.74821048
149Calcaneovalgus deformity (HP:0001848)1.69918186

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.74617062
2PDGFRA4.30763150
3TNIK3.14754274
4EPHA33.13209131
5SIK12.86600519
6TTN2.85648809
7TGFBR22.82318852
8ERBB32.73554518
9FRK2.60882134
10MAP3K62.51573674
11TRIB32.39927012
12LATS12.24516687
13TRPM72.08973054
14ZAK2.05480462
15NEK92.02843276
16PLK21.97792647
17STK31.91655566
18EPHB21.85429568
19PAK21.79295152
20ERN11.77257125
21PIK3CA1.70238607
22FER1.67940508
23PRKCH1.67897776
24PRKD21.65064959
25PKN21.64039601
26LATS21.63874087
27MYLK1.54484300
28AKT31.53339387
29PDGFRB1.48438856
30TIE11.46544020
31STK38L1.43578401
32PTK2B1.41667106
33SGK21.39977140
34PAK31.36045762
35MST1R1.32823494
36STK241.31036834
37MET1.29931044
38FGFR21.27949606
39BMX1.23619333
40MUSK1.21770162
41JAK11.20051624
42MAP3K41.18451142
43RIPK11.16932088
44ROCK11.16562867
45KIT1.11689135
46DMPK1.10339532
47PBK1.08552155
48FGFR11.07587739
49DYRK31.06712749
50FGFR31.05836732
51LRRK21.00080716
52ILK0.99240711
53PTK60.97396118
54MAP3K70.97010263
55PTK20.88636431
56TNK20.87345277
57PRKCE0.85469620
58OBSCN0.85380358
59NUAK10.83824259
60BMPR20.82387314
61INSRR0.80800010
62SGK4940.80536862
63SGK2230.80536862
64MAP3K120.80466356
65ADRBK20.80026733
66PIK3CG0.79733128
67BMPR1B0.79545785
68MAPKAPK30.79129603
69EPHB10.77003594
70STK390.76783236
71SGK30.76775505
72CSNK1G10.76298131
73OXSR10.73310372
74FGFR40.72988555
75WNK10.72403801
76PINK10.72320083
77BCR0.71602335
78PIM20.68355744
79ADRBK10.67551592
80INSR0.66470034
81NTRK10.65097253
82TGFBR10.63670953
83MAP2K70.62425237
84STK160.62040849
85ICK0.62002384
86PDK30.61206479
87PDK40.61206479
88ROCK20.61039142
89PDK20.59215067
90PRKD10.58628327
91MAP2K10.58047308
92PAK40.57783503
93MAPK110.57390470
94CDC42BPA0.57385131
95JAK30.57259640
96IGF1R0.57095914
97FLT30.55645276
98GRK10.53859245
99MOS0.52291006
100EIF2AK20.51419863
101MTOR0.50568508
102GSK3A0.49455359
103GRK50.47323766
104ABL20.47171235
105BLK0.44974918
106SRC0.43845806
107PRKAA20.43713402
108MAPKAPK50.42625699
109TAF10.42573922
110CDK60.40245155
111ACVR1B0.39694243
112MAPK120.39619494
113EEF2K0.39374442
114ABL10.37899727
115RET0.36183876
116RAF10.35784984
117CAMK2A0.35416186
118MAPK40.35239755
119PKN10.34967671
120ERBB40.34076217
121CSF1R0.34031669
122CAMK2G0.33240496
123DAPK30.32265260
124IRAK10.32174266
125MAP3K100.31182973
126CSNK1A10.29244095
127PRKG20.29042171
128DYRK1A0.27120553
129IKBKB0.26968790
130NLK0.26360502
131PRKG10.25656806
132PAK60.25200711
133MAPK10.24810086
134TYK20.24101267
135LIMK10.23209748
136TESK10.21892961
137PRPF4B0.20901632
138CAMK1D0.20382016
139MAPK70.20158463
140PLK30.19974591
141LMTK20.19051068
142MELK0.17580026

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.15767788
2Protein digestion and absorption_Homo sapiens_hsa049743.82342597
3Focal adhesion_Homo sapiens_hsa045103.26838175
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.12945917
5Malaria_Homo sapiens_hsa051442.76661330
6Amoebiasis_Homo sapiens_hsa051462.73684850
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.48180146
8Dilated cardiomyopathy_Homo sapiens_hsa054142.47232634
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.46715209
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.15453178
11Proteoglycans in cancer_Homo sapiens_hsa052052.13494631
12TGF-beta signaling pathway_Homo sapiens_hsa043502.12582059
13Circadian rhythm_Homo sapiens_hsa047101.99122965
14Adherens junction_Homo sapiens_hsa045201.87143519
15Staphylococcus aureus infection_Homo sapiens_hsa051501.86314832
16PI3K-Akt signaling pathway_Homo sapiens_hsa041511.79542816
17ABC transporters_Homo sapiens_hsa020101.51228443
18Melanoma_Homo sapiens_hsa052181.47510456
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46967503
20Linoleic acid metabolism_Homo sapiens_hsa005911.45057027
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.41894130
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40830801
23Small cell lung cancer_Homo sapiens_hsa052221.39857984
24MicroRNAs in cancer_Homo sapiens_hsa052061.36993682
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.34373528
26Prostate cancer_Homo sapiens_hsa052151.30604158
27Platelet activation_Homo sapiens_hsa046111.27578919
28Hippo signaling pathway_Homo sapiens_hsa043901.22528513
29African trypanosomiasis_Homo sapiens_hsa051431.21369082
30Chronic myeloid leukemia_Homo sapiens_hsa052201.20532968
31Basal cell carcinoma_Homo sapiens_hsa052171.16576147
32Thyroid hormone synthesis_Homo sapiens_hsa049181.14494437
33Hedgehog signaling pathway_Homo sapiens_hsa043401.13825563
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12245404
35Glioma_Homo sapiens_hsa052141.11515040
36Viral myocarditis_Homo sapiens_hsa054161.09925441
37Phototransduction_Homo sapiens_hsa047441.09816639
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07945801
39Bladder cancer_Homo sapiens_hsa052191.06922816
40Pathways in cancer_Homo sapiens_hsa052001.04222214
41Mineral absorption_Homo sapiens_hsa049781.03752241
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03347030
43Wnt signaling pathway_Homo sapiens_hsa043101.02550079
44Chemical carcinogenesis_Homo sapiens_hsa052041.02473085
45Pancreatic cancer_Homo sapiens_hsa052120.96827901
46Toxoplasmosis_Homo sapiens_hsa051450.96143904
47Starch and sucrose metabolism_Homo sapiens_hsa005000.95303190
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93415020
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92770987
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.92762617
51Arginine and proline metabolism_Homo sapiens_hsa003300.90612185
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87043150
53TNF signaling pathway_Homo sapiens_hsa046680.86340211
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85628502
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.85181214
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84630485
57Rap1 signaling pathway_Homo sapiens_hsa040150.83397115
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82195300
59Propanoate metabolism_Homo sapiens_hsa006400.81338901
60Retinol metabolism_Homo sapiens_hsa008300.80552308
61Allograft rejection_Homo sapiens_hsa053300.80516156
62Renin-angiotensin system_Homo sapiens_hsa046140.79722965
63Melanogenesis_Homo sapiens_hsa049160.78024035
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.77201738
65mTOR signaling pathway_Homo sapiens_hsa041500.76433994
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76300845
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75728097
68Ovarian steroidogenesis_Homo sapiens_hsa049130.75111309
69Caffeine metabolism_Homo sapiens_hsa002320.72507836
70Arachidonic acid metabolism_Homo sapiens_hsa005900.72154625
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70223838
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68559088
73Phagosome_Homo sapiens_hsa041450.66933137
74Estrogen signaling pathway_Homo sapiens_hsa049150.66251542
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65393719
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64672449
77Hepatitis B_Homo sapiens_hsa051610.64247139
78p53 signaling pathway_Homo sapiens_hsa041150.63882854
79Axon guidance_Homo sapiens_hsa043600.63323863
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63310340
81Ether lipid metabolism_Homo sapiens_hsa005650.62906668
82Insulin resistance_Homo sapiens_hsa049310.62867019
83Lysosome_Homo sapiens_hsa041420.62056477
84Tight junction_Homo sapiens_hsa045300.61836040
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.61746554
86AMPK signaling pathway_Homo sapiens_hsa041520.61443564
87Ras signaling pathway_Homo sapiens_hsa040140.61121887
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.59597002
89HTLV-I infection_Homo sapiens_hsa051660.59104788
90Measles_Homo sapiens_hsa051620.58710391
91Notch signaling pathway_Homo sapiens_hsa043300.58304617
92Gap junction_Homo sapiens_hsa045400.57481925
93Complement and coagulation cascades_Homo sapiens_hsa046100.57404400
94Leishmaniasis_Homo sapiens_hsa051400.57134496
95Colorectal cancer_Homo sapiens_hsa052100.56443018
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55188473
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54879931
98Fat digestion and absorption_Homo sapiens_hsa049750.54671305
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54529370
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53672397
101FoxO signaling pathway_Homo sapiens_hsa040680.52434706
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51988394
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.51336780
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51238025
105Histidine metabolism_Homo sapiens_hsa003400.50100120
106Tryptophan metabolism_Homo sapiens_hsa003800.49635987
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.48915180
108Other glycan degradation_Homo sapiens_hsa005110.48282014
109cAMP signaling pathway_Homo sapiens_hsa040240.47436669
110Type I diabetes mellitus_Homo sapiens_hsa049400.47082093
111Osteoclast differentiation_Homo sapiens_hsa043800.46862774
112Folate biosynthesis_Homo sapiens_hsa007900.46135158
113Hepatitis C_Homo sapiens_hsa051600.46025994
114Rheumatoid arthritis_Homo sapiens_hsa053230.45343823
115Influenza A_Homo sapiens_hsa051640.45164051
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44670723
117Endometrial cancer_Homo sapiens_hsa052130.44299604
118HIF-1 signaling pathway_Homo sapiens_hsa040660.43881766
119Salmonella infection_Homo sapiens_hsa051320.42938242
120PPAR signaling pathway_Homo sapiens_hsa033200.42320352
121Dorso-ventral axis formation_Homo sapiens_hsa043200.41679604
122Apoptosis_Homo sapiens_hsa042100.41642857
123Prion diseases_Homo sapiens_hsa050200.41286135
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41181087
125Galactose metabolism_Homo sapiens_hsa000520.40498036
126Calcium signaling pathway_Homo sapiens_hsa040200.40127947
127Renin secretion_Homo sapiens_hsa049240.38440461
128GnRH signaling pathway_Homo sapiens_hsa049120.38417271
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.37873080
130Asthma_Homo sapiens_hsa053100.37435069
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.37320273
132MAPK signaling pathway_Homo sapiens_hsa040100.37206936
133N-Glycan biosynthesis_Homo sapiens_hsa005100.36412646
134Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36346576
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36270880
136Oxytocin signaling pathway_Homo sapiens_hsa049210.36109454
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35957504
138Endocytosis_Homo sapiens_hsa041440.35583822
139Lysine degradation_Homo sapiens_hsa003100.34240276
140Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32817640
141Vibrio cholerae infection_Homo sapiens_hsa051100.32078445
142Pertussis_Homo sapiens_hsa051330.31586591
143Renal cell carcinoma_Homo sapiens_hsa052110.31404287

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