ASPSCR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.90220215
2proline metabolic process (GO:0006560)7.24061544
3peptidyl-glutamic acid carboxylation (GO:0017187)6.53479711
4protein carboxylation (GO:0018214)6.53479711
5transcription from mitochondrial promoter (GO:0006390)6.41655596
6negative regulation of fibrinolysis (GO:0051918)5.87594802
7DNA deamination (GO:0045006)5.78508255
8embryonic process involved in female pregnancy (GO:0060136)5.36667046
9low-density lipoprotein particle remodeling (GO:0034374)5.27252581
10regulation of cholesterol esterification (GO:0010872)5.24678927
11regulation of fibrinolysis (GO:0051917)5.23657502
12sulfur amino acid catabolic process (GO:0000098)5.19383049
13plasma lipoprotein particle remodeling (GO:0034369)5.14273250
14protein-lipid complex remodeling (GO:0034368)5.14273250
15macromolecular complex remodeling (GO:0034367)5.14273250
16protein-lipid complex assembly (GO:0065005)5.13081345
17replication fork processing (GO:0031297)5.02663649
18high-density lipoprotein particle remodeling (GO:0034375)4.90377250
19plasma lipoprotein particle organization (GO:0071827)4.79856427
20mitochondrial DNA metabolic process (GO:0032042)4.76138554
21positive regulation of protein homooligomerization (GO:0032464)4.72867147
22cholesterol efflux (GO:0033344)4.71982903
23regulation of apoptotic cell clearance (GO:2000425)4.70362436
24plasma lipoprotein particle clearance (GO:0034381)4.68567640
25glutamine family amino acid biosynthetic process (GO:0009084)4.67105450
26negative regulation of fatty acid biosynthetic process (GO:0045717)4.62800329
27regulation of cholesterol biosynthetic process (GO:0045540)4.51485510
28oxidative demethylation (GO:0070989)4.47980414
29protein-lipid complex subunit organization (GO:0071825)4.47847820
30regulation of protein homooligomerization (GO:0032462)4.36132045
31lung epithelium development (GO:0060428)4.35385580
32positive regulation of lipoprotein lipase activity (GO:0051006)4.34513036
33positive regulation of triglyceride lipase activity (GO:0061365)4.34513036
34diacylglycerol metabolic process (GO:0046339)4.34003305
35establishment of apical/basal cell polarity (GO:0035089)4.28762530
36regulation of protein activation cascade (GO:2000257)4.28069720
37reverse cholesterol transport (GO:0043691)4.26512207
38somatic hypermutation of immunoglobulin genes (GO:0016446)4.24888072
39somatic diversification of immune receptors via somatic mutation (GO:0002566)4.24888072
40maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.24489838
41regulation of complement activation (GO:0030449)4.16445574
42positive regulation of fatty acid biosynthetic process (GO:0045723)4.14807168
43regulation of integrin activation (GO:0033623)4.13941147
44blood coagulation, intrinsic pathway (GO:0007597)4.11132680
45low-density lipoprotein particle clearance (GO:0034383)3.88469662
46erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.88409310
47L-phenylalanine metabolic process (GO:0006558)3.88409310
48mannose metabolic process (GO:0006013)3.87859531
49regulation of plasminogen activation (GO:0010755)3.86044982
50glyoxylate metabolic process (GO:0046487)3.81265469
51mitotic G1 DNA damage checkpoint (GO:0031571)3.79650131
52embryonic placenta development (GO:0001892)3.73044847
53negative regulation of cholesterol transport (GO:0032375)3.71190525
54negative regulation of sterol transport (GO:0032372)3.71190525
55regulation of translational fidelity (GO:0006450)3.69983079
56establishment or maintenance of monopolar cell polarity (GO:0061339)3.69406322
57establishment of monopolar cell polarity (GO:0061162)3.69406322
58regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.66115935
59telomere maintenance via semi-conservative replication (GO:0032201)3.63232291
60formation of translation preinitiation complex (GO:0001731)3.61878591
61DNA strand renaturation (GO:0000733)3.60472821
62regulation of cholesterol metabolic process (GO:0090181)3.56119473
63mRNA cleavage (GO:0006379)3.54754676
64serine family amino acid catabolic process (GO:0009071)3.50645328
65phospholipid efflux (GO:0033700)3.46027658
66mitochondrial RNA metabolic process (GO:0000959)3.44195131
67viral mRNA export from host cell nucleus (GO:0046784)3.43839379
68cell-cell junction maintenance (GO:0045217)3.42448387
69glycine metabolic process (GO:0006544)3.42372456
70complement activation, alternative pathway (GO:0006957)3.39651001
71very-low-density lipoprotein particle assembly (GO:0034379)3.38895909
72positive regulation of systemic arterial blood pressure (GO:0003084)3.37989471
73nephron tubule morphogenesis (GO:0072078)3.37858377
74nephron epithelium morphogenesis (GO:0072088)3.37858377
75cellular anion homeostasis (GO:0030002)3.37591960
76intestinal absorption (GO:0050892)3.36023310
77peptidyl-glutamic acid modification (GO:0018200)3.35823418
78positive regulation of synapse maturation (GO:0090129)3.35780380
79poly(A)+ mRNA export from nucleus (GO:0016973)3.35326277
80mitotic G1/S transition checkpoint (GO:0044819)3.35280266
81regulation of hydrogen peroxide metabolic process (GO:0010310)3.31754885
82trivalent inorganic anion homeostasis (GO:0072506)3.30606214
83phosphate ion homeostasis (GO:0055062)3.30606214
84base-excision repair (GO:0006284)3.28819427
852-oxoglutarate metabolic process (GO:0006103)3.25564564
86phosphatidylglycerol biosynthetic process (GO:0006655)3.25497958
87L-alpha-amino acid transmembrane transport (GO:1902475)3.25465419
88L-phenylalanine catabolic process (GO:0006559)3.22526995
89erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.22526995
90DNA strand elongation involved in DNA replication (GO:0006271)3.22048898
91alkaloid metabolic process (GO:0009820)3.21486754
92modified amino acid transport (GO:0072337)3.20909764
93regulation of triglyceride biosynthetic process (GO:0010866)3.19159007
94positive regulation of triglyceride biosynthetic process (GO:0010867)3.17769890
95cholesterol homeostasis (GO:0042632)3.17088246
96lipoprotein metabolic process (GO:0042157)3.16375539
97regulation of cholesterol homeostasis (GO:2000188)3.16269474
98heme transport (GO:0015886)3.15258204
99response to misfolded protein (GO:0051788)3.14934942
100negative regulation of sodium ion transport (GO:0010766)3.14441465
101regulation of bile acid biosynthetic process (GO:0070857)3.13728773
102negative regulation of fatty acid metabolic process (GO:0045922)3.13370020
103negative regulation of cell cycle arrest (GO:0071157)3.11892379
104negative regulation of DNA-templated transcription, elongation (GO:0032785)3.11619278
105intestinal cholesterol absorption (GO:0030299)3.11197583
106aromatic amino acid family catabolic process (GO:0009074)3.10487590
107sterol homeostasis (GO:0055092)3.08618252
108kynurenine metabolic process (GO:0070189)3.07143668
109nucleotide-excision repair, DNA gap filling (GO:0006297)3.06448236
110negative regulation of protein oligomerization (GO:0032460)3.05511508
111DNA strand elongation (GO:0022616)3.03051399
112serine family amino acid metabolic process (GO:0009069)3.02852186
113glutamate metabolic process (GO:0006536)3.02760453
114G1 DNA damage checkpoint (GO:0044783)3.01881540
115positive regulation of CREB transcription factor activity (GO:0032793)3.01668361
116cysteine metabolic process (GO:0006534)3.00537892
117dosage compensation (GO:0007549)3.00479900
118indole-containing compound catabolic process (GO:0042436)3.00211960
119indolalkylamine catabolic process (GO:0046218)3.00211960
120tryptophan catabolic process (GO:0006569)3.00211960
121spliceosomal tri-snRNP complex assembly (GO:0000244)2.99899066
122positive regulation of triglyceride metabolic process (GO:0090208)2.97850444
123acylglycerol homeostasis (GO:0055090)2.97217157
124triglyceride homeostasis (GO:0070328)2.97217157
125mitochondrial DNA replication (GO:0006264)2.96550596
126negative regulation of digestive system process (GO:0060457)2.94413379
127regulation of fatty acid biosynthetic process (GO:0042304)2.93304484
128cytolysis (GO:0019835)2.91916871
129negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.91675929
130acute-phase response (GO:0006953)2.91611128
131positive regulation of steroid metabolic process (GO:0045940)2.91383824
132serine family amino acid biosynthetic process (GO:0009070)2.90823736
133regulation of synapse maturation (GO:0090128)2.90630726
134telomere maintenance via recombination (GO:0000722)2.88677633
135positive regulation of protein kinase C signaling (GO:0090037)2.87944742
136sterol transport (GO:0015918)2.87279874
137cholesterol transport (GO:0030301)2.87279874
138positive regulation of protein oligomerization (GO:0032461)2.87159620
139regulation of cholesterol storage (GO:0010885)2.86712331
140regulation of gene silencing by RNA (GO:0060966)2.86660927
141regulation of posttranscriptional gene silencing (GO:0060147)2.86660927
142regulation of gene silencing by miRNA (GO:0060964)2.86660927
143regulation of triglyceride metabolic process (GO:0090207)2.86240306
144histone H4-K12 acetylation (GO:0043983)2.86074444
145positive regulation of fatty acid metabolic process (GO:0045923)2.83386198
146nucleotide salvage (GO:0043173)2.82830444
147negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.80928335
148GDP-mannose metabolic process (GO:0019673)2.80845432
149tyrosine metabolic process (GO:0006570)2.80535024
150triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.80311881
151NAD biosynthetic process (GO:0009435)2.79094734
152base-excision repair, AP site formation (GO:0006285)2.79090758
153vitamin transmembrane transport (GO:0035461)2.78899087
154tryptophan metabolic process (GO:0006568)2.78635840
155arginine metabolic process (GO:0006525)2.76240595
156pentose metabolic process (GO:0019321)2.74979934
157nodal signaling pathway (GO:0038092)2.74578424
158regulation of double-strand break repair via homologous recombination (GO:0010569)2.74297336
159negative regulation of JAK-STAT cascade (GO:0046426)2.73833818
160regulation of protein oligomerization (GO:0032459)2.71464643
161DNA integration (GO:0015074)2.71155003
162basic amino acid transport (GO:0015802)2.70092814
163double-strand break repair via nonhomologous end joining (GO:0006303)2.69755065
164non-recombinational repair (GO:0000726)2.69755065
165bile acid metabolic process (GO:0008206)2.69580288
166apoptotic process involved in morphogenesis (GO:0060561)2.69492589
167positive regulation by host of viral transcription (GO:0043923)2.68515366
168trophectodermal cell differentiation (GO:0001829)2.67846311
169cell junction maintenance (GO:0034331)2.67622828
170alpha-linolenic acid metabolic process (GO:0036109)2.66099733
171folic acid-containing compound biosynthetic process (GO:0009396)2.64837696
172alanine transport (GO:0032328)2.64279704
173pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.63404450
174glutathione biosynthetic process (GO:0006750)2.62715640
175regulation of glycogen (starch) synthase activity (GO:2000465)2.62315761
176cellular zinc ion homeostasis (GO:0006882)2.61855612
177plasma lipoprotein particle assembly (GO:0034377)2.61400714
178urea cycle (GO:0000050)2.61026025
179urea metabolic process (GO:0019627)2.61026025
180fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.60755551
181L-ascorbic acid metabolic process (GO:0019852)2.60642833
182anatomical structure regression (GO:0060033)2.60232358
183meiotic chromosome segregation (GO:0045132)2.58903215
184bile acid biosynthetic process (GO:0006699)2.57568113

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.73113924
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.22075353
3E2F7_22180533_ChIP-Seq_HELA_Human3.06405851
4* RXR_22158963_ChIP-Seq_LIVER_Mouse2.82503414
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.76430597
6* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.60450333
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.58368506
8* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.57098332
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.53938053
10CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.43503114
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.31262782
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.26650648
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.26650648
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.26650648
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.15008958
16STAT3_1855785_ChIP-Seq_MESCs_Mouse2.10863544
17ERG_21242973_ChIP-ChIP_JURKAT_Human2.05246771
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04179696
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.99346886
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97989846
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.96824468
22NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.95262713
23VDR_21846776_ChIP-Seq_THP-1_Human1.92541460
24NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.88774232
25KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.87818865
26LXR_22158963_ChIP-Seq_LIVER_Mouse1.86687350
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.85495671
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.84857904
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.84216530
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.82144375
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.81016512
32SMC4_20622854_ChIP-Seq_HELA_Human1.80548720
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.79189220
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.78280507
35LXR_22292898_ChIP-Seq_THP-1_Human1.76388614
36SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.74888478
37* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.72975902
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.71378917
39SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.70985103
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70290699
41SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.69920300
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69456461
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67813622
44SA1_27219007_Chip-Seq_ERYTHROID_Human1.66632097
45MYC_22102868_ChIP-Seq_BL_Human1.66388376
46* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66317758
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.66162233
48SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.61584483
49CTCF_27219007_Chip-Seq_Bcells_Human1.61547625
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58056415
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57071657
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54775850
53POU5F1_16518401_ChIP-PET_MESCs_Mouse1.54355873
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52629803
55* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.51990770
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.50887961
57* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50851141
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48059556
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.46798345
60TCF3_18692474_ChIP-Seq_MESCs_Mouse1.46103057
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45938653
62KDM2B_26808549_Chip-Seq_DND41_Human1.44807666
63RXRA_24833708_ChIP-Seq_LIVER_Mouse1.42838869
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42143053
65* FOXP1_21924763_ChIP-Seq_HESCs_Human1.41415309
66PU.1_20513432_ChIP-Seq_Bcells_Mouse1.39295953
67EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.39276369
68TP53_22127205_ChIP-Seq_IMR90_Human1.38955853
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37696286
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37669565
71TCF7_22412390_ChIP-Seq_EML_Mouse1.37356169
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36788047
73CREB1_26743006_Chip-Seq_LNCaP_Human1.36653626
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36459593
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35370917
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35190195
77MAF_26560356_Chip-Seq_TH2_Human1.34570957
78SA1_27219007_Chip-Seq_Bcells_Human1.34009084
79MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.32759039
80CTCF_26484167_Chip-Seq_Bcells_Mouse1.32750158
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.30895717
82NANOG_21062744_ChIP-ChIP_HESCs_Human1.28833988
83CTCF_20526341_ChIP-Seq_ESCs_Human1.28697142
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25885911
85KDM2B_26808549_Chip-Seq_K562_Human1.25822481
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24652698
87UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24135630
88RACK7_27058665_Chip-Seq_MCF-7_Human1.22754457
89* RARB_24833708_ChIP-Seq_LIVER_Mouse1.22732234
90* RARA_24833708_ChIP-Seq_LIVER_Mouse1.22190767
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21019921
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.20803059
93* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.20257236
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19069809
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18813156
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18663346
97* GABP_19822575_ChIP-Seq_HepG2_Human1.18280039
98* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17593808
99ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17529260
100SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17444415
101GATA1_19941827_ChIP-Seq_MEL_Mouse1.17265900
102NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.16686270
103BCOR_27268052_Chip-Seq_Bcells_Human1.16683075
104ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16631571
105SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16190538
106DROSHA_22980978_ChIP-Seq_HELA_Human1.15289207
107NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15097289
108ZNF263_19887448_ChIP-Seq_K562_Human1.14820653
109OCT4_19829295_ChIP-Seq_ESCs_Human1.14789807
110TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.14545467
111BCL6_27268052_Chip-Seq_Bcells_Human1.14286663
112* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13775260
113PHF8_20622854_ChIP-Seq_HELA_Human1.13714189
114ETS1_20019798_ChIP-Seq_JURKAT_Human1.13355353
115* FOXA2_19822575_ChIP-Seq_HepG2_Human1.13297274
116TP63_22573176_ChIP-Seq_HFKS_Human1.13115651
117THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11960652
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11903495
119ETS1_21867929_ChIP-Seq_TH2_Mouse1.11743943
120SOX2_18692474_ChIP-Seq_MESCs_Mouse1.11722210
121OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11497725
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11008047
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10777008
124CTCF_21964334_Chip-Seq_Bcells_Human1.10086760
125ERA_21632823_ChIP-Seq_H3396_Human1.09636275
126* ESR2_21235772_ChIP-Seq_MCF-7_Human1.09453101
127SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09184233
128SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.09107819
129DCP1A_22483619_ChIP-Seq_HELA_Human1.09029933
130MAF_26560356_Chip-Seq_TH1_Human1.08211106
131XRN2_22483619_ChIP-Seq_HELA_Human1.08125116
132P300_27268052_Chip-Seq_Bcells_Human1.07221122
133YY1_22570637_ChIP-Seq_MALME-3M_Human1.07087084
134ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06554126
135STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05861701
136ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05831698
137RAC3_21632823_ChIP-Seq_H3396_Human1.05704119
138ELK3_25401928_ChIP-Seq_HUVEC_Human1.05429476
139VDR_24763502_ChIP-Seq_THP-1_Human1.04082573
140CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02759737
141GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02121593
142* UTX_26944678_Chip-Seq_JUKART_Human1.01995855
143P68_20966046_ChIP-Seq_HELA_Human1.01884114
144KDM5A_27292631_Chip-Seq_BREAST_Human1.01574640
145ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00796102
146ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00761429
147SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00634669
148JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00298721
149CTCF_21964334_ChIP-Seq_BJAB-B_Human1.00017169
150GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99914031
151TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98686418
152ELF1_20517297_ChIP-Seq_JURKAT_Human0.97090568
153E2F1_20622854_ChIP-Seq_HELA_Human0.97089509
154MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96591631
155CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96584714
156CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96516473
157* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95999333
158TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95558002
159CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95309822

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.13514411
2MP0008057_abnormal_DNA_replication4.02144672
3MP0005085_abnormal_gallbladder_physiolo3.98834588
4MP0005365_abnormal_bile_salt3.85574515
5MP0005360_urolithiasis3.73539517
6MP0003122_maternal_imprinting3.54698574
7MP0003806_abnormal_nucleotide_metabolis3.30233733
8MP0003195_calcinosis3.24520185
9MP0009278_abnormal_bone_marrow3.23961341
10MP0002089_abnormal_postnatal_growth/wei2.86942124
11MP0010030_abnormal_orbit_morphology2.67280353
12MP0003123_paternal_imprinting2.63469668
13MP0000566_synostosis2.47874283
14MP0005167_abnormal_blood-brain_barrier2.14044044
15MP0009840_abnormal_foam_cell2.06552901
16MP0005171_absent_coat_pigmentation2.05392040
17MP0005451_abnormal_body_composition2.04466650
18MP0008875_abnormal_xenobiotic_pharmacok2.02928909
19MP0003252_abnormal_bile_duct2.01885479
20MP0010094_abnormal_chromosome_stability2.00841659
21MP0004233_abnormal_muscle_weight1.96292103
22MP0005377_hearing/vestibular/ear_phenot1.92218700
23MP0003878_abnormal_ear_physiology1.92218700
24MP0001545_abnormal_hematopoietic_system1.91259317
25MP0005397_hematopoietic_system_phenotyp1.91259317
26MP0002653_abnormal_ependyma_morphology1.83463914
27MP0004957_abnormal_blastocyst_morpholog1.81727889
28MP0003136_yellow_coat_color1.79948358
29MP0003111_abnormal_nucleus_morphology1.78092491
30MP0009384_cardiac_valve_regurgitation1.71385550
31MP0004019_abnormal_vitamin_homeostasis1.66212892
32MP0004133_heterotaxia1.65187729
33MP0008058_abnormal_DNA_repair1.64612792
34MP0002249_abnormal_larynx_morphology1.63624341
35MP0000003_abnormal_adipose_tissue1.62482778
36MP0005332_abnormal_amino_acid1.57752075
37MP0003191_abnormal_cellular_cholesterol1.54196775
38MP0010352_gastrointestinal_tract_polyps1.53496407
39MP0010329_abnormal_lipoprotein_level1.52492267
40MP0003890_abnormal_embryonic-extraembry1.51538851
41MP0003283_abnormal_digestive_organ1.49117431
42MP0003693_abnormal_embryo_hatching1.46791018
43MP0008995_early_reproductive_senescence1.44136824
44MP0003786_premature_aging1.43370975
45MP0002933_joint_inflammation1.42116236
46MP0001666_abnormal_nutrient_absorption1.40655642
47MP0005083_abnormal_biliary_tract1.40416172
48MP0000609_abnormal_liver_physiology1.40386536
49MP0003436_decreased_susceptibility_to1.35430779
50MP0003077_abnormal_cell_cycle1.32862341
51MP0003119_abnormal_digestive_system1.32592560
52MP0003879_abnormal_hair_cell1.32309656
53MP0002269_muscular_atrophy1.31130237
54MP0003453_abnormal_keratinocyte_physiol1.30528108
55MP0000371_diluted_coat_color1.29675700
56MP0002086_abnormal_extraembryonic_tissu1.27849622
57MP0003705_abnormal_hypodermis_morpholog1.27231285
58MP0002009_preneoplasia1.27150163
59MP0005319_abnormal_enzyme/_coenzyme1.25525890
60MP0001986_abnormal_taste_sensitivity1.25099289
61MP0003329_amyloid_beta_deposits1.25065053
62MP0000678_abnormal_parathyroid_gland1.24531345
63MP0003656_abnormal_erythrocyte_physiolo1.23217309
64MP0005075_abnormal_melanosome_morpholog1.22561922
65MP0004043_abnormal_pH_regulation1.19289142
66MP0000490_abnormal_crypts_of1.16441938
67MP0001697_abnormal_embryo_size1.16273470
68MP0008932_abnormal_embryonic_tissue1.14525180
69MP0001764_abnormal_homeostasis1.13723586
70MP0001293_anophthalmia1.13190992
71MP0009643_abnormal_urine_homeostasis1.12269842
72MP0002282_abnormal_trachea_morphology1.11839505
73MP0004197_abnormal_fetal_growth/weight/1.11399321
74MP0004264_abnormal_extraembryonic_tissu1.11306181
75MP0005174_abnormal_tail_pigmentation1.11031267
76MP0003172_abnormal_lysosome_physiology1.08746280
77MP0005058_abnormal_lysosome_morphology1.07902073
78MP0004381_abnormal_hair_follicle1.07802637
79MP0001661_extended_life_span1.06541733
80MP0005266_abnormal_metabolism1.06234766
81MP0000604_amyloidosis1.06106751
82MP0001730_embryonic_growth_arrest1.05776163
83MP0000598_abnormal_liver_morphology1.05665526
84MP0004858_abnormal_nervous_system1.04891360
85MP0003186_abnormal_redox_activity1.03467473
86MP0002084_abnormal_developmental_patter1.03164439
87MP0001672_abnormal_embryogenesis/_devel1.02404185
88MP0005380_embryogenesis_phenotype1.02404185
89MP0002019_abnormal_tumor_incidence1.02404156
90MP0000685_abnormal_immune_system1.02402077
91MP0002085_abnormal_embryonic_tissue1.01623749
92MP0009333_abnormal_splenocyte_physiolog1.01470858
93MP0002876_abnormal_thyroid_physiology1.00971593
94MP0003183_abnormal_peptide_metabolism1.00298810
95MP0002118_abnormal_lipid_homeostasis0.98500341
96MP0005636_abnormal_mineral_homeostasis0.95886077
97MP0005448_abnormal_energy_balance0.94545343
98MP0005076_abnormal_cell_differentiation0.94495402
99MP0005023_abnormal_wound_healing0.94349786
100MP0009642_abnormal_blood_homeostasis0.94236691
101MP0008260_abnormal_autophagy0.93842856
102MP0005410_abnormal_fertilization0.93601793
103MP0000350_abnormal_cell_proliferation0.92980023
104MP0005408_hypopigmentation0.92722332
105MP0000579_abnormal_nail_morphology0.92614306
106MP0001873_stomach_inflammation0.92399402
107MP0003718_maternal_effect0.91976592
108MP0003646_muscle_fatigue0.89725453
109MP0005670_abnormal_white_adipose0.88632855
110MP0001348_abnormal_lacrimal_gland0.88586829
111MP0003121_genomic_imprinting0.87790754
112MP0002080_prenatal_lethality0.86718219
113MP0009053_abnormal_anal_canal0.86249179
114MP0008877_abnormal_DNA_methylation0.86106795
115MP0005647_abnormal_sex_gland0.85553451
116MP0004130_abnormal_muscle_cell0.84894835
117MP0002796_impaired_skin_barrier0.82686814
118MP0000639_abnormal_adrenal_gland0.82570557
119MP0001145_abnormal_male_reproductive0.80721275
120MP0003984_embryonic_growth_retardation0.80398977
121MP0003567_abnormal_fetal_cardiomyocyte0.79262532
122MP0005220_abnormal_exocrine_pancreas0.78630041
123MP0009115_abnormal_fat_cell0.78295867
124MP0002088_abnormal_embryonic_growth/wei0.77984085
125MP0005409_darkened_coat_color0.76879002
126MP0002111_abnormal_tail_morphology0.76660887
127MP0002078_abnormal_glucose_homeostasis0.76642983
128MP0001929_abnormal_gametogenesis0.76636855
129MP0001270_distended_abdomen0.76030115
130MP0004742_abnormal_vestibular_system0.76021066
131MP0005551_abnormal_eye_electrophysiolog0.75423882
132MP0001765_abnormal_ion_homeostasis0.74952530
133MP0010307_abnormal_tumor_latency0.74622519
134MP0001756_abnormal_urination0.73540877
135MP0006036_abnormal_mitochondrial_physio0.73157850
136MP0002132_abnormal_respiratory_system0.71695610
137MP0008469_abnormal_protein_level0.71425953
138MP0003942_abnormal_urinary_system0.71201550
139MP0002932_abnormal_joint_morphology0.70902912
140MP0000470_abnormal_stomach_morphology0.70604523
141MP0002938_white_spotting0.70460611
142MP0002405_respiratory_system_inflammati0.69606676
143MP0000313_abnormal_cell_death0.69236064
144MP0005330_cardiomyopathy0.68375677
145MP0005376_homeostasis/metabolism_phenot0.68317956
146MP0006082_CNS_inflammation0.68155914
147MP0005395_other_phenotype0.67819609
148MP0002970_abnormal_white_adipose0.67154659
149MP0001324_abnormal_eye_pigmentation0.66584866
150MP0006292_abnormal_olfactory_placode0.66365544
151MP0005584_abnormal_enzyme/coenzyme_acti0.65811878
152MP0005375_adipose_tissue_phenotype0.65215048
153MP0000013_abnormal_adipose_tissue0.65166716
154MP0000747_muscle_weakness0.61951814
155MP0003953_abnormal_hormone_level0.61534349
156MP0005464_abnormal_platelet_physiology0.61138686
157MP0002075_abnormal_coat/hair_pigmentati0.60794212
158MP0001915_intracranial_hemorrhage0.59798472
159MP0008961_abnormal_basal_metabolism0.58735202
160MP0002138_abnormal_hepatobiliary_system0.55443460
161MP0002254_reproductive_system_inflammat0.55048029
162MP0003638_abnormal_response/metabolism_0.54260745
163MP0002160_abnormal_reproductive_system0.52772868
164MP0006035_abnormal_mitochondrial_morpho0.52078788

Predicted human phenotypes

RankGene SetZ-score
1Joint hemorrhage (HP:0005261)5.16780762
2Hemorrhage of the eye (HP:0011885)5.00095878
3Hypochromic microcytic anemia (HP:0004840)4.51311754
4Pustule (HP:0200039)4.37469672
5Hypobetalipoproteinemia (HP:0003563)4.24131815
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.10812575
7Abnormality of monocarboxylic acid metabolism (HP:0010996)3.96643438
8Rib fusion (HP:0000902)3.95386822
9Intrahepatic cholestasis (HP:0001406)3.91951543
10Alopecia of scalp (HP:0002293)3.89149267
11Turricephaly (HP:0000262)3.76489311
12Rectal fistula (HP:0100590)3.73033351
13Rectovaginal fistula (HP:0000143)3.73033351
14Tongue fasciculations (HP:0001308)3.69362268
15Vaginal fistula (HP:0004320)3.67666466
16Poikiloderma (HP:0001029)3.57612673
17Facial hemangioma (HP:0000329)3.48272074
18Increased IgM level (HP:0003496)3.47813161
19Muscle fibrillation (HP:0010546)3.40832576
20Intestinal fistula (HP:0100819)3.36286735
21Glomerulonephritis (HP:0000099)3.28415748
22Ulnar bowing (HP:0003031)3.25559229
23Annular pancreas (HP:0001734)3.23125223
24J-shaped sella turcica (HP:0002680)3.20207804
25Systemic lupus erythematosus (HP:0002725)3.20180756
26Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.14491573
27Abnormality of pyrimidine metabolism (HP:0004353)3.09604535
28Deep venous thrombosis (HP:0002625)3.08721426
29Purpura (HP:0000979)3.07251721
30Concave nail (HP:0001598)3.05699225
31Male infertility (HP:0003251)3.01556345
32Menorrhagia (HP:0000132)2.93670308
33Short humerus (HP:0005792)2.91549005
34Hypoplasia of the capital femoral epiphysis (HP:0003090)2.87704923
35Hypercholesterolemia (HP:0003124)2.86735456
36Xanthomatosis (HP:0000991)2.86585001
37Hyperammonemia (HP:0001987)2.82784843
38Aplasia/hypoplasia of the humerus (HP:0006507)2.82591424
39Hypolipoproteinemia (HP:0010981)2.76877473
40Increased serum ferritin (HP:0003281)2.76698387
41Urinary glycosaminoglycan excretion (HP:0003541)2.74631478
42Mucopolysacchariduria (HP:0008155)2.74631478
43Abnormality of the common coagulation pathway (HP:0010990)2.72876401
44Polycythemia (HP:0001901)2.72755088
45Abnormal hemoglobin (HP:0011902)2.70993937
46Hypochromic anemia (HP:0001931)2.70213285
47Albinism (HP:0001022)2.68976837
48Hyperglycinuria (HP:0003108)2.68716111
49Abnormality of male internal genitalia (HP:0000022)2.67867525
50Intestinal atresia (HP:0011100)2.64159937
51Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.63545793
52Vertebral hypoplasia (HP:0008417)2.63545793
53Small epiphyses (HP:0010585)2.62671162
54Ketosis (HP:0001946)2.59898975
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.58515589
56Squamous cell carcinoma (HP:0002860)2.56736261
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.55371039
58Abnormality of mucopolysaccharide metabolism (HP:0011020)2.55371039
59Abnormality of polysaccharide metabolism (HP:0011012)2.55371039
60Abnormality of sulfur amino acid metabolism (HP:0004339)2.54636608
61Flared iliac wings (HP:0002869)2.52979907
62Orthostatic hypotension (HP:0001278)2.48320285
63Pancreatic islet-cell hyperplasia (HP:0004510)2.45417235
64Hyperglycinemia (HP:0002154)2.44901005
65Cerebral aneurysm (HP:0004944)2.44490144
66Testicular atrophy (HP:0000029)2.44467643
67Absent epiphyses (HP:0010577)2.43055690
68Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.43055690
69Myocardial infarction (HP:0001658)2.42964869
70Absent thumb (HP:0009777)2.41743161
71Selective tooth agenesis (HP:0001592)2.40875930
72Coronal craniosynostosis (HP:0004440)2.39798030
73Malnutrition (HP:0004395)2.36984975
74Bronchomalacia (HP:0002780)2.35712112
75Large for gestational age (HP:0001520)2.34939741
76Abnormality of the lower motor neuron (HP:0002366)2.34272343
77Absent radius (HP:0003974)2.33102918
78Mesangial abnormality (HP:0001966)2.32938020
79Broad alveolar ridges (HP:0000187)2.32409493
80Abnormality of glutamine family amino acid metabolism (HP:0010902)2.31640307
81Dysautonomia (HP:0002459)2.29606958
82Prolonged partial thromboplastin time (HP:0003645)2.29452138
83Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.27517218
84Opisthotonus (HP:0002179)2.25772657
85Basal cell carcinoma (HP:0002671)2.24978339
86Hypophosphatemic rickets (HP:0004912)2.24742713
87Growth hormone excess (HP:0000845)2.22266565
88Ketoacidosis (HP:0001993)2.21114714
89Biconcave vertebral bodies (HP:0004586)2.21027064
90Abnormality of serine family amino acid metabolism (HP:0010894)2.20942998
91Abnormality of glycine metabolism (HP:0010895)2.20942998
92Supernumerary bones of the axial skeleton (HP:0009144)2.20585097
93Abnormality of transition element cation homeostasis (HP:0011030)2.18057148
94Abnormality of iron homeostasis (HP:0011031)2.17676950
95Increased cerebral lipofuscin (HP:0011813)2.17354340
96Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.16302865
97Abnormality of methionine metabolism (HP:0010901)2.15346172
98Seborrheic dermatitis (HP:0001051)2.14408512
99Aplasia involving forearm bones (HP:0009822)2.13807616
100Absent forearm bone (HP:0003953)2.13807616
101Complement deficiency (HP:0004431)2.09943243
102Fat malabsorption (HP:0002630)2.08979852
103Rectal prolapse (HP:0002035)2.08593450
104Abnormality of endocrine pancreas physiology (HP:0012093)2.08357081
105Abnormality of the pancreatic islet cells (HP:0006476)2.08357081
106Joint stiffness (HP:0001387)2.06982057
107Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.06696980
108Abnormality of the vitreous humor (HP:0004327)2.05211111
109Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05035061
110Diaphragmatic weakness (HP:0009113)2.03321745
111Hyperlipoproteinemia (HP:0010980)2.03153791
112Congenital hip dislocation (HP:0001374)2.01378218
113Abnormality of the Achilles tendon (HP:0005109)2.01192112
114Abnormal enzyme/coenzyme activity (HP:0012379)2.01004615
115Patellar aplasia (HP:0006443)2.00632675
116Generalized amyotrophy (HP:0003700)2.00426246
117Spastic diplegia (HP:0001264)1.99745324
118Pigmentary retinal degeneration (HP:0001146)1.97386914
119Cerebral palsy (HP:0100021)1.97147444
120Short femoral neck (HP:0100864)1.97011532
121Dysostosis multiplex (HP:0000943)1.96510348
122Reticulocytosis (HP:0001923)1.95948350
123Abnormality of the aortic arch (HP:0012303)1.95818011
124Hypokinesia (HP:0002375)1.94832837
125Retinal atrophy (HP:0001105)1.94503501
126Lower limb hyperreflexia (HP:0002395)1.94369673
127Premature graying of hair (HP:0002216)1.93464993
128Stridor (HP:0010307)1.93422752
129Ragged-red muscle fibers (HP:0003200)1.92608454
130Abnormality of alkaline phosphatase activity (HP:0004379)1.92462557
131Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.92289781
132Asymmetric septal hypertrophy (HP:0001670)1.91921551
133Epiphyseal dysplasia (HP:0002656)1.91818112
134Delayed CNS myelination (HP:0002188)1.91456331
135Abnormality of complement system (HP:0005339)1.90791323
136Bowing of the arm (HP:0006488)1.90789118
137Bowed forearm bones (HP:0003956)1.90789118
138Hypoalphalipoproteinemia (HP:0003233)1.89458620
139Irregular epiphyses (HP:0010582)1.89396085
140Abnormality of nucleobase metabolism (HP:0010932)1.87721638
141Abnormal number of erythroid precursors (HP:0012131)1.86369287
142Spontaneous abortion (HP:0005268)1.86263854
143Choanal stenosis (HP:0000452)1.85992523
144Aplasia/Hypoplasia of the patella (HP:0006498)1.81306278
145Enlarged kidneys (HP:0000105)1.81245176
146Abnormality of the thoracic spine (HP:0100711)1.80775715
147Hyperthyroidism (HP:0000836)1.80283252
148Clumsiness (HP:0002312)1.79920537
149Supernumerary ribs (HP:0005815)1.77841163
150Hyperacusis (HP:0010780)1.76698640
151Renal duplication (HP:0000075)1.75776074
152Nasolacrimal duct obstruction (HP:0000579)1.75440085
153Gastrointestinal infarctions (HP:0005244)1.74657099
154Microvesicular hepatic steatosis (HP:0001414)1.74545533
155Myopathic facies (HP:0002058)1.73214127
156Hydroxyprolinuria (HP:0003080)1.73016437
157Abnormality of proline metabolism (HP:0010907)1.73016437
158Abnormality of the radial head (HP:0003995)1.71085001
159Hypertriglyceridemia (HP:0002155)1.69724408
160Increased muscle lipid content (HP:0009058)1.65140561
161Epidermoid cyst (HP:0200040)1.64703677
162Acanthocytosis (HP:0001927)1.64384390
163Supernumerary nipples (HP:0002558)1.63929627
164Abnormality of carpal bone ossification (HP:0006257)1.63632116
165Generalized aminoaciduria (HP:0002909)1.63356940
166Premature skin wrinkling (HP:0100678)1.63338361
167Abnormal urine output (HP:0012590)1.63193765

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.47646368
2MAPK154.28127260
3DDR24.07622834
4MAP3K63.66181223
5WNK43.34104978
6MAP3K113.31966046
7PINK12.96750241
8MATK2.94833035
9SIK22.71089507
10TYRO32.34969007
11BCKDK2.31706609
12PIM22.20816807
13CSK2.06558445
14DYRK1B2.06550767
15SMG11.97711807
16DAPK11.96957065
17CDK71.88140201
18FGR1.80546660
19BMX1.75028383
20TLK11.72689136
21PRKD21.69364905
22NME11.68832875
23MAP3K101.66758694
24IRAK31.63061741
25PDGFRA1.62872399
26TNK21.60964324
27MAP2K61.58802401
28YES11.47111394
29FGFR31.47027295
30ERN11.46962952
31PIM11.44157180
32MAPK111.41617200
33UHMK11.36968631
34TRIB31.32515929
35CDK61.31212635
36MARK21.29409163
37TBK11.28856691
38NEK21.26301580
39CDK121.24839693
40AKT31.22864194
41TAOK21.20346210
42MAP3K71.18902905
43PLK11.17705346
44CHEK21.16749200
45BUB11.13730713
46DYRK31.13146345
47LATS21.10948986
48RIPK11.08898741
49TTK1.06540162
50EPHA21.04635536
51PDPK11.03661591
52SIK11.02259694
53RPS6KC11.00479486
54RPS6KL11.00479486
55RPS6KB20.93413009
56MAPKAPK30.92518387
57MTOR0.92125070
58FLT30.90850889
59ATR0.90034104
60TESK20.90024831
61RPS6KA60.89506977
62INSRR0.89261950
63WEE10.88111827
64MUSK0.87609785
65TRPM70.86586424
66PTK60.85561404
67GSK3A0.83192362
68NEK10.80839162
69MAP4K10.78785110
70TXK0.76182736
71CDC42BPA0.74528355
72RPS6KA20.74030593
73ZAK0.73094214
74PRKD30.70643635
75FGFR40.70264800
76PHKG20.67387513
77PHKG10.67387513
78FGFR20.67257836
79CDK40.66141455
80PDK10.65462343
81RPS6KA10.65292679
82IKBKB0.64687808
83PRKAA10.63895043
84ACVR1B0.63735852
85CAMK1D0.62566476
86ITK0.61516373
87TESK10.60562412
88KDR0.60381809
89PDK30.60009571
90PDK40.60009571
91NTRK30.58085804
92CAMKK10.57089629
93TTN0.55827025
94GRK60.54655832
95CDC70.54229634
96ZAP700.53993259
97AURKA0.53701984
98ERBB20.51395250
99CSF1R0.50501196
100IRAK40.50100691
101NTRK20.50094180
102PAK40.49523843
103TAOK30.49405057
104CDK20.49354635
105CSNK2A10.47987948
106PKN20.47755944
107MAP3K10.47666553
108PRKCI0.47635544
109STK100.46674728
110AURKB0.46035045
111CDK80.45276574
112BLK0.45175394
113DAPK20.44035929
114MAPKAPK50.43667043
115WNK10.43588871
116MAPK120.41770470
117RET0.41480384
118MAP3K80.41041184
119MAPK80.40950097
120HIPK20.40143823
121STK38L0.39897838
122CHEK10.39565823
123LYN0.38507794
124RPS6KA50.38149944
125MAPK40.37866856
126MAPK30.37713191
127PRKAA20.37571391
128RPS6KB10.35942787
129PRKCZ0.35499246
130IKBKE0.35160484
131SYK0.35081704
132CAMK40.34861603
133PDK20.33605571
134TAOK10.33215163
135VRK20.33047477
136MAPK10.32791593
137ATM0.32711440
138PKN10.32476534
139MAPKAPK20.31964024
140CHUK0.31390067
141EGFR0.30530612
142PTK20.29879164
143EEF2K0.29843340
144CSNK2A20.29352031
145MAP3K30.28231068
146DYRK20.28050258
147MAP2K30.27860764
148MAP2K20.27563562
149LATS10.26106236
150NME20.25698220
151ERBB30.24599304
152STK30.24259909

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.93275459
2Mismatch repair_Homo sapiens_hsa034303.09680523
3Fatty acid biosynthesis_Homo sapiens_hsa000613.06756592
4Base excision repair_Homo sapiens_hsa034102.95363960
5DNA replication_Homo sapiens_hsa030302.85209455
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.65153155
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.35616043
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22593128
9Arginine biosynthesis_Homo sapiens_hsa002202.19467125
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.17769308
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.12593883
12Biosynthesis of amino acids_Homo sapiens_hsa012302.10904347
13Folate biosynthesis_Homo sapiens_hsa007902.00324688
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.97945100
15Sulfur relay system_Homo sapiens_hsa041221.95821214
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.91939263
17Selenocompound metabolism_Homo sapiens_hsa004501.87140467
18Fatty acid metabolism_Homo sapiens_hsa012121.86560544
19Tryptophan metabolism_Homo sapiens_hsa003801.85852341
20One carbon pool by folate_Homo sapiens_hsa006701.82609776
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68295327
22Arginine and proline metabolism_Homo sapiens_hsa003301.66719956
23Fatty acid degradation_Homo sapiens_hsa000711.55264982
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.47784066
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47737563
26Nucleotide excision repair_Homo sapiens_hsa034201.46493992
27Nitrogen metabolism_Homo sapiens_hsa009101.44911241
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38891820
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.37095335
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31275112
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.31256993
32Lysine degradation_Homo sapiens_hsa003101.28866095
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27981936
34Fructose and mannose metabolism_Homo sapiens_hsa000511.27972815
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24938217
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24462362
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.23774457
38Complement and coagulation cascades_Homo sapiens_hsa046101.23738330
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23541734
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22082225
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.20349130
42Linoleic acid metabolism_Homo sapiens_hsa005911.18138260
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18117671
44Propanoate metabolism_Homo sapiens_hsa006401.16549184
45Peroxisome_Homo sapiens_hsa041461.16503365
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.15606719
47Carbon metabolism_Homo sapiens_hsa012001.14003005
48RNA transport_Homo sapiens_hsa030131.12915187
49Homologous recombination_Homo sapiens_hsa034401.12479773
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11918968
51Pyruvate metabolism_Homo sapiens_hsa006201.04239305
52Spliceosome_Homo sapiens_hsa030401.04095275
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03137465
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01973300
55PPAR signaling pathway_Homo sapiens_hsa033201.01933514
56Glutathione metabolism_Homo sapiens_hsa004801.01752196
57Lysosome_Homo sapiens_hsa041421.01389926
58p53 signaling pathway_Homo sapiens_hsa041151.00871488
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00311074
60beta-Alanine metabolism_Homo sapiens_hsa004100.99950626
61Chemical carcinogenesis_Homo sapiens_hsa052040.99301977
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97612354
63Galactose metabolism_Homo sapiens_hsa000520.97374708
64Fanconi anemia pathway_Homo sapiens_hsa034600.95171536
65Starch and sucrose metabolism_Homo sapiens_hsa005000.94702718
66Vitamin B6 metabolism_Homo sapiens_hsa007500.90582759
67Fat digestion and absorption_Homo sapiens_hsa049750.88107114
68N-Glycan biosynthesis_Homo sapiens_hsa005100.87581642
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84988146
70Notch signaling pathway_Homo sapiens_hsa043300.84946454
71Insulin resistance_Homo sapiens_hsa049310.84771388
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83595285
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.82318172
74Cell cycle_Homo sapiens_hsa041100.81293302
75ABC transporters_Homo sapiens_hsa020100.79748545
76VEGF signaling pathway_Homo sapiens_hsa043700.79471079
77Retinol metabolism_Homo sapiens_hsa008300.78524509
78mRNA surveillance pathway_Homo sapiens_hsa030150.78171621
79Histidine metabolism_Homo sapiens_hsa003400.77089083
80Phenylalanine metabolism_Homo sapiens_hsa003600.76925752
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76690446
82Pentose phosphate pathway_Homo sapiens_hsa000300.76557552
83Butanoate metabolism_Homo sapiens_hsa006500.75760123
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.73062457
85Ether lipid metabolism_Homo sapiens_hsa005650.72397434
86Bladder cancer_Homo sapiens_hsa052190.71528315
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71143694
88Caffeine metabolism_Homo sapiens_hsa002320.70663271
89Arachidonic acid metabolism_Homo sapiens_hsa005900.70064505
90mTOR signaling pathway_Homo sapiens_hsa041500.67728219
91Staphylococcus aureus infection_Homo sapiens_hsa051500.67375683
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.65046696
93Bile secretion_Homo sapiens_hsa049760.64846353
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64780683
95Hedgehog signaling pathway_Homo sapiens_hsa043400.63807838
96Steroid biosynthesis_Homo sapiens_hsa001000.62331371
97Pyrimidine metabolism_Homo sapiens_hsa002400.61388902
98Tyrosine metabolism_Homo sapiens_hsa003500.60510064
99Hippo signaling pathway_Homo sapiens_hsa043900.58697906
100Circadian rhythm_Homo sapiens_hsa047100.57574004
101Glucagon signaling pathway_Homo sapiens_hsa049220.55785745
102Ovarian steroidogenesis_Homo sapiens_hsa049130.55522277
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50398016
104Glycerolipid metabolism_Homo sapiens_hsa005610.48230654
105Fatty acid elongation_Homo sapiens_hsa000620.47891727
106Adherens junction_Homo sapiens_hsa045200.43957723
107Primary immunodeficiency_Homo sapiens_hsa053400.42363956
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42314298
109Thyroid hormone synthesis_Homo sapiens_hsa049180.41338399
110Metabolic pathways_Homo sapiens_hsa011000.41335088
111Basal cell carcinoma_Homo sapiens_hsa052170.40192540
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38773073
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38637822
114Prion diseases_Homo sapiens_hsa050200.37512621
115Legionellosis_Homo sapiens_hsa051340.36237035
116Shigellosis_Homo sapiens_hsa051310.35854795
117AMPK signaling pathway_Homo sapiens_hsa041520.35405816
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34694416
119TGF-beta signaling pathway_Homo sapiens_hsa043500.33702936
120Sphingolipid metabolism_Homo sapiens_hsa006000.33364628
121Proteasome_Homo sapiens_hsa030500.33277841
122Vitamin digestion and absorption_Homo sapiens_hsa049770.31821246
123Sulfur metabolism_Homo sapiens_hsa009200.30118290
124Thyroid cancer_Homo sapiens_hsa052160.30011401
125RNA polymerase_Homo sapiens_hsa030200.29405545
126Non-small cell lung cancer_Homo sapiens_hsa052230.25228532
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24911005
128Insulin signaling pathway_Homo sapiens_hsa049100.22851089
129Pertussis_Homo sapiens_hsa051330.22798869
130Mineral absorption_Homo sapiens_hsa049780.18940229
131Systemic lupus erythematosus_Homo sapiens_hsa053220.18074289

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